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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 9. Отображено 9.
27-09-2012 дата публикации

MIXED CRYSTAL AGOMELATINE (FORM-VIII), PREPARATION METHOD AND USE THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

Номер: WO2012126386A1
Автор: HUANG, Yu, LONG, Qing, ZHU, Xueyan, SHAN, Hanbin, YUAN, Zhedong, YU, Xiong
Принадлежит:

The present invention provides a mixed crystal agomelatine (Form-VIII), the preparation method and use thereof and a pharmaceutical composition containing the same, wherein the mixed crystal mainly contains an agomelatine crystal form VI. The mixed crystal is stable and has good reproducibility, and is found through a stability test to be superior to a crystal form VI in terms of stability. Therefore, the Form-VIII of the present invention has an advantage in terms of preparation.

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Номер записи: 1
02-09-2010 дата публикации

AGOMELATINE HYDROHALIDE COMPLEX AND PREPARATION METHOD THEREOF

Номер: WO2010097052A1
Автор: ZHANG, Peng, SHAN, Hanbin, YUAN, Zhedong, JIANG, Xudong, HUANG, Yu, WANG, Hubo, CAO, Xufeng, CHENG, Xingdong, PAN, Hongjuan, YU, Xiong
Принадлежит:

Agomelatine hydrohalide complex and preparation method thereof are disclosed. Compared with agomelatine, agomelatine hydrohalide complex obtained by the present method has improved solubility, and is suitable for application need of preparation of finished products of drugs. Furthermore, the product has good stability and high purity. The preparation process is simple and convenient, and the product with high purity can be obtained without special operations.

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Номер записи: 2
18-05-2012 дата публикации

PROLINAMIDE DERIVATIVE AS THROMBIN INHIBITOR, PREPARATION METHOD AND APPLICATION THEREOF

Номер: WO2012062187A1
Автор: LI, Min, SHAN, Hanbin, HUANG, Yu, YUAN, Zhedong, YU, Xiong
Принадлежит:

Provided are a compound of formula (I), pharmaceutically acceptable salts thereof, preparation methods and applications thereof for inhibiting thrombin, and applications in the treatment and prevention of thrombin-mediated and thrombin-related diseases.

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Номер записи: 3
27-09-2012 дата публикации

NEW CRYSTAL FORM VII OF AGOMELATINE, PREPARATION METHOD AND USE THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

Номер: WO2012126385A1
Автор: HUANG, Yu, TONG, Ling, ZHU, Xueyan, SHAN, Hanbin, YUAN, Zhedong, YU, Xiong
Принадлежит:

The present invention provides a new crystal form VII of agomelatine, the preparation method and use thereof and a pharmaceutical composition containing the same. The new crystal form has a good purity, a stable crystal form and good reproducibility; the preparation method thereof is easy to amplify; and it is superior to most previously reported crystal forms in terms of stability and solubility. Therefore, the crystal form VII of the present invention has an advantage in terms of preparation.

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Номер записи: 4
21-07-2023 дата публикации

Nemategravir solvate, nemategravir crystal form A, and preparation method and application of nemategravir solvate

Номер: CN116462735A
Автор: ZHONG JIALIANG, PAN HONGJUAN, SHAN HANBIN, GONG YANQING, LI GANG, MA YUYING, MA LIWEN
Принадлежит:

The invention discloses a nemategravir solvate, a nemategravir crystal form A, and a preparation method and application thereof. Specifically, the invention provides an isobutyl acetate solvate of a compound as shown in a formula I, a crystal form A, and a preparation method and application of the isobutyl acetate solvate. The crystal form has the advantages of good stability and purity, low hygroscopicity, easy preservation, simple process route and low cost, and is suitable for new drug development and industrial production.

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Номер записи: 5
16-09-2010 дата публикации

NEW CRYSTALLINE FORM VI OF AGOMELATINE, PREPARATION METHOD AND APPLICATION THEREOF

Номер: WO2010102554A1
Автор: SHAN, Hanbin, ZHANG, Peng, YUAN, Zhedong, JIANG, Xudong, HUANG, Yu, WANG, Hubo, CAO, Xufeng, CHENG, Xingdong, YU, Xiong
Принадлежит:

A new crystalline form of Agomelatine, its preparation method and application are provided. There are main peaks where diffraction angles 2θ are 11.13, 11.82, 17.49, 18.29, 19.48, 19.72, 20.50, 21.76, 22.54, 22.97, 24.56, 25.36, 27.16 and 31.93 in the X-ray diffraction pattern of the crystalline form powder of Agomelatine. The new crystalline form has good purity, stability and repeatability, and has advantages in pharmaceutics. In addition, the stability and solubility are better than those of current crystalline forms.

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Номер записи: 6
07-01-2016 дата публикации

METHOD OF PREPARING DABIGATRAN ETEXILATE INTERMEDIATE AND INTERMEDIATE COMPOUND

Номер: WO2016000230A1
Автор: GUO, Yajun, SHAN, Hanbin, ZHU, Xueyan, YUAN, Zhedong, YU, Xiong
Принадлежит:

Disclosed are a method of preparing a dabigatran etexilate intermediate and an intermediate compound. The method of preparing a dabigatran etexilate intermediate 4 comprises the following steps: reacting a compound 3 with a C1-C3 alkyl alcohol solution of methylamine in an organic solvent, X = chlorine, bromine or iodine. Also disclosed are an intermediate compound 3 and preparation method thereof. The method of preparing a dabigatran etexilate intermediate is simple, easy to operate with high yield, is easy to purify, and suitable for industrial production.

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Номер записи: 7
16-06-2023 дата публикации

Eutectic of flurbiprofen and arginine and preparation method thereof

Номер: CN116262697A
Автор: CHEN XIANCHONG, ZHONG JIALIANG, SHAN HANBIN, HOU JIAWEI, GONG YANQING, YUAN SHUGUANG
Принадлежит:

The invention provides a eutectic crystal of flurbiprofen and arginine and a preparation method of the eutectic crystal. Specifically, the invention discloses that the ratio of the amount of substance of flurbiprofen to the amount of substance of arginine in the eutectic crystal of flurbiprofen and arginine is 1: 1; an X-ray powder diffraction pattern of the eutectic crystal of flurbiprofen and arginine has the following characteristic peaks of Bragg angles 2theta: 5.408 degrees, 10.794 degrees, 13.756 degrees, 18.214 degrees, 18.886 degrees, 21.884 degrees, 22.577 degrees and 23.028 degrees. According to the method for preparing the flurbiprofen eutectic crystal, the solubility of the flurbiprofen is improved, especially in a nearly neutral buffer solution, the solubility is improved by more than 200 times, meanwhile, the flurbiprofen eutectic crystal has the stability under high-temperature and high-humidity conditions, the preparation method is very simple, complex instruments and reagents ...

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Номер записи: 8
16-06-2023 дата публикации

Co-crystal of fenoprofen calcium and maleimide and preparation method thereof

Номер: CN116262720A
Автор: CHEN XIANCHONG, ZHONG JIALIANG, SHAN HANBIN, HOU JIAWEI, GONG YANQING, YUAN SHUGUANG
Принадлежит:

The invention relates to a co-crystal of fenoprofen calcium and maleimide and a preparation method of the co-crystal, and particularly discloses the co-crystal of fenoprofen calcium and maleimide, and the mass ratio of fenoprofen calcium to maleimide in the co-crystal is 1: 1. An X-ray powder diffraction pattern of the eutectic crystal of fenoprofen calcium and maleimide has the following characteristic peaks of Bragg angles 2theta: 4.835 degrees, 7.5 20 degrees, 8.267 degrees, 9.612 degrees and 16.674 degrees. According to the invention, fenoprofen calcium and maleimide can form the eutectic crystal, and the preparation method is very simple, does not need complex instruments and reagents, and is low in cost, high in yield and easy to control. According to the method for preparing the fenoprofen calcium into the eutectic crystal, the solubility of the fenoprofen calcium is improved, and the solubility is improved by more than 4 times especially in a nearly neutral buffer solution.

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Номер записи: 9