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Применить Всего найдено 3. Отображено 3.
21-04-2023 дата публикации

Application of hinokitiol iron chelate in development of tumor inhibition drugs

Номер: CN115990153A
Автор: YIN JUNLIN, FAN BAOMIN, YUN LIH-HYEON, XU JIANBIN, ZHOU YONGYUN, ZENG GUANGZHI, CHEN JINGCHAO, GUO YAFEI, WANG KAIMIN, HE ZHENXIU, SUN YUQING, LI JIULING, PANG YUYAN, WANG AYING, WANG QIYU, HUANG JIELIN, WANG JIHONG, ZHANG QI, HU PEIYAO, ZHANG HONGYANG, ZHANG DIANHAO
Принадлежит:

The invention discloses an application of a hinokitiol iron chelate in the development of drugs for inhibiting tumors, and the research shows that the compound can induce ferroptosis of cells so as to achieve the purpose of inhibiting proliferation of tumor cells, especially proliferation of breast cancer cells. A new treatment scheme is developed on the basis of inducing ferroptosis by the hinokitiol iron chelate, and the hinokitiol iron chelate can be used as a new strategy for treating various diseases in the future on the basis of the property of inducing ferroptosis by the hinokitiol iron chelate, especially for treating breast cancer.

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Номер записи: 1
23-06-2023 дата публикации

Anti-aging and anti-ultraviolet damage hirudin extract freeze-dried essence and production process thereof

Номер: CN116270287A
Автор: YIN JUNLIN, FAN BAOMIN, WANG AYING, WANG QIYU, HUANG JIELIN, XU JIANBIN, ZHOU YONGYUN, ZENG GUANGZHI, CHEN JINGCHAO, GUO YAFEI, WANG KAIMIN, HE ZHENXIU, SUN YUQING, LI JIULING, PANG YUYAN
Принадлежит:

The invention discloses anti-aging and anti-ultraviolet damage hirudin extract freeze-dried essence and a preparation method thereof. The freeze-dried essence is prepared from freeze-dried powder and solvent liquid, the freeze-dried powder is prepared from a hirudin extract, mannitol, oligopeptide-3, ceramide, trehalose and arginine; the solvent liquid is prepared from glycerol, propylene glycol, hydrolyzed sodium hyaluronate, dipotassium glycyrrhizinate, hexapeptide-9, butanediol, squalane, PEG (Polyethylene Glycol) castor oil, hydrolyzed collagen, nicotinamide and water; the water extract freeze-dried essence prepared by the method provided by the invention still retains the activity while removing fishy odor; through a freeze-drying technology, inactivation of hirudin in a liquid environment can be avoided, the stability can be improved, the activity can be retained, and long-term storage and use are facilitated; the active raw materials of the product are stable and effective, the addition ...

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Номер записи: 2
26-05-2023 дата публикации

Alkynyl sulfone derivative as well as preparation method and application thereof

Номер: CN116162046A
Автор: XU JIANBIN, ZENG GUANGZHI, LIU NA, FAN BAOMIN, HE ZHENXIU, SUN YUQING, FAN RUIFENG, YANG XIAOJU
Принадлежит:

The invention discloses an alkynyl sulfone derivative, the structural general formula of which is as shown in formula (I), when R1 is methoxy, R2 is selected from 4-trifluoromethyl, 4-trifluoromethoxy, 4-tert-butyl, 4-bromine, 4-chlorine, 4-cyano and 2-methyl, and when R1 is methoxy, R2 is selected from 4-trifluoromethyl, 4-trifluoromethoxy, 4-tert-butyl, 4-bromine, 4-chlorine, 4-cyano and 2-methyl; when R1 is hydrogen, R2 is selected from 4-methyl and 4-phenyl; and when R2 is methyl, R1 is selected from thiophene, 4-chlorine, 4-isopropyl, 4-bromine and 4-ester group. The alkynyl sulfone compound is synthesized from benzenesulfonyl hydrazide and alkynyl bromide under the promotion of visible light, and the method is mild in reaction condition, free of harmful substances in the synthesis process, environmentally friendly, high in yield, low in cost, convenient to operate, capable of achieving small-dose reaction and suitable for industrial production. The alkynyl sulfone compound 1-14 provided ...

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Номер записи: 3