Organ targeting polymer nano vesicle system as well as preparation method and application thereof

The invention belongs to the technical field of polymer nano-drugs, and particularly relates to an organ-targeted polymer nano-vesicle system as well as a preparation method and application thereof. The system comprises organ targeting polymer nano-vesicles and macromolecular drugs in the organ targeting polymer nano-vesicles, the organ targeting polymer nano vesicle sequentially comprises a hydrophilic inner shell, a hydrophobic membrane layer, a hydrophilic outer shell and a charge group embedded in the hydrophilic outer shell from inside to outside, the system is prepared by assembling a cationic polymer, an auxiliary polymer and a macromolecular drug together. The organ-targeted polymer nano-vesicle has a vesicle-shaped structure, the inner cavity can load a hydrophilic substance, the hydrophobic membrane layer can load a hydrophobic substance, and the hydrophilic shell can effectively protect the loaded substance; by embedding different charge groups in the hydrophilic shell, different ...