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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Применить Всего найдено 6. Отображено 6.
30-11-2017 дата публикации

NICOTINYL ALCOHOL ETHER DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USES THEREOF

Номер: WO2017202274A1
Автор: FENG, Zhiqiang, CHEN, Xiaoguang, YANG, Yang, ZHENG, Yi, LAI, Fangfang, JI, Ming, ZHOU, Chuan, ZHANG, Lijing, WANG, Ke, XUE, Nina, LI, Ling
Принадлежит:

Disclosed are a nicotinyl alcohol ether derivative, a preparation method therefor, and a pharmaceutical composition and uses thereof. Specifically, the present invention relates to nicotinyl alcohol ether derivative represented by formula (I), a pharmaceutically-acceptable salt thereof, a stereoisomer thereof, a preparation method therefor, a pharmaceutical composition containing the one or more compounds, and uses of the compounds in treating diseases related to PD-1/PD-L1 signal channels, such as cancers, infectious diseases and autoimmune diseases.

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Номер записи: 1
30-11-2017 дата публикации

PHENYLATE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USES THEREOF

Номер: WO2017202276A1
Автор: FENG, Zhiqiang, CHEN, Xiaoguang, YANG, Yang, ZHOU, Chuan, LAI, Fangfang, JI, Ming, JIN, Xiaofeng, XUE, Nina, ZHENG, Yi, CHEN, Hao, LI, Ling
Принадлежит:

A phenylate derivative, a preparation method therefor, and a pharmaceutical composition and uses thereof. Specifically, the present invention relates to a phenylate derivative represented by formula I, a pharmaceutically-acceptable salt thereof, a stereoisomer thereof, a preparation method therefor, and a pharmaceutical composition containing the one or more compounds, and uses of the compounds in treating diseases related to PD-1/PD-L1 signal channels, such as cancers, infectious diseases and autoimmune diseases.

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Номер записи: 2
30-11-2017 дата публикации

METHOD FOR PREPARING 2-HYDROXYL-4-(2, 3-DISUBSTITUTED BENZYLOXY)-5-SUBSTITUTED BENZALDEHYDE DERIVATIVE

Номер: WO2017202277A1
Автор: FENG, Zhiqiang, CHEN, Xiaoguang, YANG, Yang, LAI, Fangfang
Принадлежит:

Provided is a method for preparing 2-hydroxyl-4-(2, 3-disubstituted benzyloxy)-5-substituted benzaldehyde derivative represented by formula (I). The method comprises the following steps: (1), preparing 2-substitution-3-aryl toluene derivative 2 by using a 2-substitution-3-iodotoluene derivative 1 and arylboronic acid 5 or aryl borate ester as raw materials; (2), preparing a benzyl halide derivative by using 2-substitution-3-aryl toluene derivative 2 as a raw material; and (3), preparing 2-hydroxyl-4-(2, 3-disubstituted benzyloxy)-5-substituted benzaldehyde derivative by using the benzyl halide derivative 3 and 2, 4-dyhydroxy-5-substituted benzaldehyde 6.

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Номер записи: 3
27-09-2012 дата публикации

RUTAECARPINE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF

Номер: WO2012126280A1
Автор: SI, Shuyi, XU, Yanni, LIU, Qi, JIANG, Jiandong, HONG, Bin, LI, Zhuorong, JIANG, Wei, HE, Xiaobo, XU, Yang, LI, Yongzhen, LAI, Fangfang, WU, Yexiang, LI, Ni, WANG, Zhimin, LIU, Wei
Принадлежит:

Provided are a rutaecarpine compound, a preparation method therefor, and a use thereof. The rutaecarpine compound, as represented in the compound of Formula (I) and the compound of Formula (2), is used in an up-regulator or an agonist for up-regulating ABCA1, SR-B1/CLA-1, and LXR α and for activating LXR α and PPAR γ, or in the preparation of drugs for treating or preventing atherosclerosis.

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Номер записи: 4
30-11-2017 дата публикации

BROMO BENZYL ETHER DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USES THEREOF

Номер: WO2017202275A1
Автор: FENG, Zhiqiang, CHEN, Xiaoguang, ZHANG, Lijing, YANG, Yang, LAI, Fangfang, JI, Ming, ZHOU, Chuan, ZHEN, Yi, XUE, Nina, LI, Ling
Принадлежит:

Disclosed in the present invention are a bromo benzyl ether derivative, a preparation method therefor, and a pharmaceutical composition and uses thereof. Specifically, the present invention relates to a bromo benzyl ether derivative represented by formula I, a pharmaceutically-acceptable salt thereof, a stereoisomer thereof, and a preparation method therefor, a pharmaceutical composition containing the one or more compounds, and uses of the compounds in treating diseases related to PD-1/PD-L1 signal channels, such as cancers, infectious diseases and autoimmune diseases.

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Номер записи: 5
30-11-2017 дата публикации

BENZYL PHENYL ETHER DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USES THEREOF

Номер: WO2017202273A1
Автор: FENG, Zhiqiang, CHEN, Xiaoguang, YANG, Yang, LAI, Fangfang, JI, Ming, ZHANG, Lijing, ZHENG, Yi, XUE, Nina, WANG, Ke, LI, Ling
Принадлежит:

Disclosed in the present invention are a benzyl phenyl ether derivative, a preparation method therefor, and a pharmaceutical composition and uses thereof. Specifically, the present invention relates to a benzyl phenyl ether derivative represented by formula I, a pharmaceutically-acceptable salt thereof, a stereoisomer thereof, a preparation method therefor, and a pharmaceutical composition containing the one or more compounds, and uses of the compounds in treating diseases related to PD-1/PD-L1 signal channels, such as cancers, infectious diseases and autoimmune diseases.

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Номер записи: 6