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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 15. Отображено 15.
04-08-2011 дата публикации

CONDUCTIVE RAIL JOINT

Номер: WO2011091554A1
Автор: ZHOU, Licheng, YANG, Yaping
Принадлежит:

A conductive rail joint comprises a left conductive rail (1), a middle rail (2), a right conductive rail (3), supporting plates (4), electric conductors (5) and conductive wires (6). The opposite end faces of the three rails are slant and parallel with each other. The supporting plates (4), the electric conductors (5) and the conductive wires (6) respectively consist of a left one and a right one. The two supporting plates are axial non-symmetrically mounted at the bottom of the corresponding conductive rails (1, 3) respectively. One end of each electric conductor (51, 52) is fixed to the corresponding supporting plate (41, 42) and the other end is suspended. Each of the two conductive wires (61, 62) is connected between the fixed end of the corresponding electric conductor (51, 52) and the suspended end of the other electric conductor (52, 51). The conductive wires (6) are loose after the connection. The conductive wires (6) and the electric conductors (5) consist of a loop so that when ...

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Номер записи: 1
15-08-2019 дата публикации

ANTI-PD-1/ANTI-VEGF NATURAL ANTIBODY STRUCTURE-LIKE HETERODIMERIC FORM BISPECIFIC ANTIBODY AND PREPARATION THEREOF

Номер: WO2019154349A1
Автор: YANG, Yaping, SONG, Nanmeng, XIAO, Wenchu, LI, Zhenlei, ZHANG, Lina, GU, Mingyue, ZHAN, Chunguang, LIU, Jiawang, KIM, Maengsup
Принадлежит:

An anti-PD-1/anti-VEGF natural antibody structure-like heterodimeric form bispecific antibody and the preparation thereof. Provided are a highly stable, heterodimeric form anti-PD-1/anti-VEGF bispecific antibody having natural IgG characteristics and free of mismatched heavy and light chains and a preparation method for the antibody. The bispecific antibody is capable of simultaneously binding with two target molecules and provides improved efficacy in treating a complicated disease.

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Номер записи: 2
12-05-2016 дата публикации

RECOMBINANT FUSION PROTEIN FOR SIMULTANEOUSLY BLOCKING B7/CD28 AND IL6/IL6R/GP130 SIGNAL PATHS

Номер: WO2016070769A1
Автор: YANG, Yaping, LIU, Jiawang, SONG, Nanmeng, CHEN, Guoqing, ZHANG, Lei, ZHANG, Xiaoyan, QIU, Hongjuan, CHA, Mi Young
Принадлежит:

Disclosed are a bifunctional fusion protein comprising an extracellular domain of a CTLA4 molecule and a functional fragment with neutralized IL6 activity, a coding gene of the bifunctional fusion protein, a carrier comprising the gene, a host cell comprising the carrier, and a pharmaceutical composition comprising the fusion protein. The functional fragment with the neutralized IL6 activity is a monoclonal antibody against IL6. The extracellular domain of the CTLA4 molecule is located at an N end of a heavy chain of the monoclonal antibody against IL6, and is connected by using a connecting peptide. The bifunctional fusion protein in the present invention can simultaneously block B7/CD28 and IL6/IL6R/GP130 signal paths, so as to suppress an inflammatory reaction.

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Номер записи: 3
13-06-2019 дата публикации

ANTI-PD-L1/ANTI-CD47 BISPECIFIC ANTIBODY WITH STRUCTURE LIKE NATURAL ANTIBODY AND IN FORM OF HETERODIMER AND PREPARATION THEREOF

Номер: WO2019109876A1
Автор: LIU, Jiawang, YANG, Yaping, SONG, Nanmeng, KIM, Maengsup
Принадлежит:

Provided are an anti-PD-L1/anti-CD47 bispecific antibody that has natural IgG characteristics and is in a highly stable heterodimer form without the heavy chain and light chain being mismatched, and a preparation method therefor. Either the first Fc chain or second Fc chain of the bispecific antibody includes amino acid substitutions at positions 366 and 399, and the other includes amino acid substitutions at positions 351, 407 and 409.

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Номер записи: 4
04-04-2023 дата публикации

Home-based care environment improvement method based on historical multi-dimensional data stream and active feedback

Номер: CN115908076A
Автор: YANG YAPING, WANG DONG, PEI HUILI, ZHENG YANNAN, FAN CHENGXIANG, XIE SHIFA, LI HUAN, LUO YUN
Принадлежит:

The invention discloses a home-based old-age care environment improvement method based on historical multi-dimensional data streams and active feedback, and belongs to the technical field of old-age care environment improvement methods. Comprising the steps of extracting a physiological demand guiding factor, extracting a safety demand guiding factor, extracting a socialization guiding factor, performing active feedback on the physiological demand guiding factor, the safety demand guiding factor and the socialization guiding factor, and evaluating the home-based care environment by utilizing logistic regression through the obtained active feedback information. According to the method, the demand guide evaluation factor and the socialization guide evaluation factor are extracted on the basis of the historical multi-dimensional data flow and the active feedback information, so that a comprehensive evaluation index for the home-based care environment is formed, and whether the home-based care ...

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Номер записи: 5
22-03-2018 дата публикации

ANTIBODY SPECIFICALLY BINDING TO PD-1 AND FUNCTIONAL FRAGMENT THEREOF

Номер: WO2018050027A1
Автор: YANG, Yaping, LIU, Jiawang, SONG, Nanmeng, ZHANG, Hongjuan, JIN, Mengxie
Принадлежит:

An antibody specifically binding to PD-1 and a functional fragment thereof. The antibody or functional fragment thereof includes a PD-1 chimeric antibody and a functional fragment thereof, and a PD-1 humanized antibody and a functional fragment thereof.

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Номер записи: 6
22-03-2018 дата публикации

ANTIBODY SPECIFICALLY BINDING TO IL-17A AND FUNCTIONAL FRAGMENT THEREOF

Номер: WO2018050028A1
Автор: SONG, Nanmeng, LIU, Jiawang, YANG, Yaping, YANG, Yang, YANG, Dongge, ZHANG, Hongjuan, JIN, Mengxie
Принадлежит:

An antibody specifically binding to IL-17A and a functional fragment thereof. The antibody or functional fragment thereof includes an IL-17A chimeric antibody and a functional fragment thereof, and an IL-17A humanized antibody and a functional fragment thereof.

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Номер записи: 7
14-05-2020 дата публикации

ANTI-TNFα/ANTI IL‐17A NATURAL ANTIBODY STRUCTURE-LIKE HETERODIMER FORM OF BISPECIFIC ANTIBODY AND PREPARATION METHOD THEREFOR

Номер: WO2020093990A1
Автор: LIU, Jiawang, YANG, Yaping, SONG, Nanmeng, XIAO, Wenchu, CHUNG, Chulwoong, KIM, Maengsup
Принадлежит:

Provided are an anti-TNFα/anti IL-17A natural antibody structure-like heterodimer form of a bispecific antibody and a preparation method therefor, wherein the antibody can bind two target molecules simultaneously, and can be used for treating complex diseases.

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Номер записи: 8
05-03-2015 дата публикации

BIFUNCTIONAL FUSION PROTEIN, PREPARATION METHOD THEREFOR, AND USE THEREOF

Номер: WO2015027906A1
Автор: YANG, Yaping, LIU, Jiawang, LI, Ying, CHEN, Guoqing, ZHANG, Lei, ZHANG, Xiaoyan, QIU, Hongjuan, CHA, Mi Young
Принадлежит:

Provided are a bifunctional fusion protein having a CTLA4 molecule extracellular region, an Fc fragment, and a functional fragment that neutralizes TNFα activity, a gene for encoding the bifunctional fusion protein, a carrier having the gene, a host cell having the carrier, and a pharmaceutical composition having the bifunctional fusion protein. The functional fragment that neutralizes TNFα activity is a TNFR2 molecule extracellular region or an anti-TNFα single-chain antibody, wherein the CTLA4 molecule extracellular region is located at the N-terminus of the bifunctional protein, and the TNFR2 molecule extracellular region or the anti-TNFα scFv is located in the middle or the C-terminus of the bifunctional protein. The bifunctional fusion protein can simultaneously block the signal pathways of B7/CD28 and TNFα/TNFR, thereby inhibiting inflammation reactions. Comparing to single-function proteins, the present invention can lower the production cost, reduce clinically administered medicine ...

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Номер записи: 9
15-08-2019 дата публикации

ANTI-PD-1/ANTI-HER2 NATURAL ANTIBODY STRUCTURE-LIKE BISPECIFIC ANTIBODY IN HETERODIMERIC FORM AND PREPARATION THEREOF

Номер: WO2019153200A1
Автор: LIU, Jiawang, SONG, Nanmeng, YANG, Yaping, KIM, Maeng Sup, YAN, Yao, YIN, Qingqing
Принадлежит:

Provided are an anti-PD-1/anti-HER2 natural antibody structure-like bispecific antibody in heterodimeric form and a preparation method therefor. The antibody can bind two target molecules simultaneously, and can be used for treating complex diseases.

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Номер записи: 10
06-08-2015 дата публикации

BIFUNCTIONAL FUSION PROTEIN, PREPARATION METHOD THEREFOR, AND USE THEREOF

Номер: WO2015113494A1
Автор: CHEN, Guoqiang, LIU, Jiawang, SONG, Nanmeng, YANG, Yaping, CHA, Mi Young
Принадлежит:

The present invention provides a bifunctional fusion protein comprising the extracellular region of CTLA4 and an anti-IL-17 antibody, a gene encoding the protein, a vector comprising the gene, a host cell comprising the vector, and a pharmaceutical composition containing the protein.

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Номер записи: 11
24-05-2018 дата публикации

ANTI-PD-1/ANTI-HER2 NATURAL ANTIBODY STRUCTURE-LIKE BISPECIFIC ANTIBODY OF HETERODIMERIC FORM AND PREPARATION THEREOF

Номер: WO2018090950A1
Автор: LIU, Jiawang, SONG, Nanmeng, YANG, Yaping, KIM, Maengsup
Принадлежит:

Provided are an anti-PD-1/anti-HER2 bispecific antibody of a heterodimeric form having the characteristics of a natural IgG and a preparation method therefor. The antibody binds both target molecules simultaneously, and can be used to treat complex diseases.

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Номер записи: 12
04-10-2018 дата публикации

ANTI-PD-L1/ANTI-PD-1 NATURAL ANTIBODY STRUCTURE-LIKE HETERODIMERIC BISPECIFIC ANTIBODY AND PREPARATION THEREOF

Номер: WO2018177324A1
Автор: LIU, Jiawang, SONG, Nanmeng, YANG, Yaping, JIN, Mengxie
Принадлежит:

Provided are an anti-PD-L1/anti-PD-1 natural antibody structure-like heterodimeric bispecific antibody and a preparation thereof. In particular, provided are a highly stable heterodimeric anti-PD-L1/anti-PD-1 bispecific antibody with characteristics of a natural IgG and without mismatched heavy chain-light chain, and a preparation thereof. The bispecific antibody can bind to both target molecules and is more effective in treating a complex disease.

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Номер записи: 13
21-04-2023 дата публикации

Propolis and bitter gourd capsule preparation system and method capable of assisting in reducing blood sugar

Номер: CN115990113A
Автор: YANG YAPING, ZHANG YUANKUN, WANG ZHIBIAO
Принадлежит:

The invention relates to a propolis and bitter gourd capsule preparation system capable of assisting in reducing blood sugar, the propolis and bitter gourd capsule preparation system comprises a capsule body feeding mechanism, a medicine powder filling mechanism, a capsule cap feeding mechanism and a cover closing mechanism which are arranged on a rack, and the capsule cap feeding mechanism comprises a first screening assembly, a first recognition assembly and a material supplementing assembly; the medicine powder filling mechanism comprises a powder injection assembly and a second recognition assembly. Capsule caps of the same specification can be automatically recognized and supplemented, it is guaranteed that each capsule body has the corresponding capsule cap, the capsule assembling success rate is increased, medicine powder can be automatically recognized and injected into the positioned capsule bodies, waste of the medicine powder is avoided, the automation degree is high, the structure ...

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Номер записи: 14
29-08-2023 дата публикации

Anti-PD-L1/anti-CD47 natural antibody structure-like heterodimer form bispecific antibody and preparation thereof

Номер: CN116670289A
Автор: LIU JIAWANG, YANG YAPING, ZHAO SIQI, LIU YANG, SONG NANMENG, ZHANG HONGJUAN, YANG DONGXUE, ZHANG LANXIN, WANG JING, XU JIANGCHENG, LEE KYUNG-WOO
Принадлежит:

The invention provides an anti-PD-L1/anti-CD47 bispecific antibody and a preparation method of the anti-PD-L1/anti-CD47 bispecific antibody. The antibody has the characteristics of natural IgG, and is in a highly stable heterodimer form without heavy and light chain mismatch. The bispecific antibody can be combined with two target molecules at the same time and has smaller side effects.

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Номер записи: 15