Hyaluronic acid derivative as well as preparation method and application thereof

The invention relates to a hyaluronic acid derivative as shown in a formula I, a preparation method of the hyaluronic acid derivative and application of the hyaluronic acid derivative in preparation of anti-infective drugs. The compound or pharmaceutically acceptable salt of the hyaluronic acid derivative and commercially available hyaluronic acid substances such as TCIsHA and Ramp; the structures of the DHA are remarkably different, and the DHA can form a molecular structure recognized by HepSS-1. The molecule with the novel structure can play an anti-infection role by inhibiting the combination of SARS-Cov-2 spike protein and ACE2 of host cells, and compared with heparin, the molecule has the advantage that serious adverse reactions such as bleeding and thrombocytopenia are not easily caused clinically.