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Применить Всего найдено 3. Отображено 3.
21-03-2019 дата публикации

METHOD AND KIT FOR SYNTHESIZING NUCLEIC ACID UNDER CONSTANT TEMPERATURE CONDITIONS

Номер: WO2019051732A1
Автор: DU, Yuguang, MAO, Rui, WANG, Zhuo
Принадлежит:

Provided are a method and kit for synthesizing a nucleic acid under constant temperature conditions, the method comprising: 1) providing a nucleic acid, wherein the 5'-terminus of the nucleic acid has an Nc region that can be annealed to the N region on the same chain, while the 3'-terminus of the nucleic acid has an Nc region that can be annealed with the N region on the same chain, and the Nc regions of the 5'-terminus and the 3'-terminus of the nucleic acid have a competitive relationship against annealing with the N regions on the same chain; 2) using the nucleic acid described in step 1) as a template and the 3'-terminus of the Nc region that has been annealed with the N region as a starting point of synthesis to synthesize its own complementary strand; and 3) carrying out the complementary strand synthesis by means of a polymerase catalytic strand displacement type complementary strand synthesis reaction to replace the complementary strand synthesized in step 2). The nucleic acid ...

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Номер записи: 1
26-07-2018 дата публикации

METHOD FOR SYNTHESIZING NUCLEIC ACID UNDER CONSTANT TEMPERATURE

Номер: WO2018132939A1
Автор: DU, Yuguang, MAO, Rui, LIU, Hongtao, WANG, Zhuo
Принадлежит:

A method for synthesizing nucleic acid under constant temperature, comprising the following steps: 1) providing a nucleic acid, the 3' end of the nucleic acid has an Flr region, the Flr region anneals with an Flc region on the same strand, and a helix ring may be formed by simultaneous annealing of the Flr and Flc regions; 2) using the nucleic acid in step 1) as a template to synthesize a complementary strand thereof; 3) performing complementary strand synthesis by means of a polymerase-catalyzed strand substitute complementary strand synthesis reaction to replace the synthesized complementary strand in step 2); wherein the nucleotide sequence of the oligonucleotide at the 5' end of the primer is substantially the same as a region synthesized by using the primer as a starting point.

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Номер записи: 2
28-04-2023 дата публикации

Polypeptide for inhibiting infection of novel coronavirus SARS-CoV-2 and application thereof

Номер: CN116023439A
Автор: DU YUGUANG, XU YUEQIANG, LI JIANJUN, WANG ZHUO, WANG QI, YOU XIN, DU XIAOHUI, LI YAN
Принадлежит:

The invention discloses a polypeptide for inhibiting infection of novel coronavirus SARS-CoV-2 and application of the polypeptide, and belongs to the field of biological medicine. The polypeptide and the derivative thereof are polypeptides with antiviral activity and can be combined with novel coronavirus SARS-CoV-2S1 protein, combination of SARS-CoV-2 and host cells is prevented through competitive inhibition, a host is protected against invasion of novel coronavirus, and virus infection is effectively prevented and controlled. The invention also provides an application of the polypeptide in preparation of a medicine for preventing and/or treating SARS-CoV-2.

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Номер записи: 3