Asymmetric preparation process of (S) or (R)-Ugi amine and tartrate thereof

The invention provides an asymmetric preparation process of (S) or (R)-Ugi amine and tartrate thereof. The chiral Ugi amine can be used for synthesizing a series of chiral phosphine ligands taking ferrocene as a skeleton structure, and has wide application in asymmetric hydrogenation reaction. According to the invention, ferrocene is used as a raw material, and the Ugi amine with single optical activity and the tartrate thereof are obtained through the steps of acetylation, asymmetric reduction hydrogenation, esterification, amination, salification and the like. The method has the advantages of cheap and easily available raw materials, mild reaction conditions, simple synthesis route, high yield, high chiral purity and less generation of three wastes, is suitable for industrial production, and has great economic value and social benefit.