04-07-2023 дата публикации
Номер: CN116375662A
Принадлежит:
The invention belongs to the field of medical intermediates, and particularly discloses an efficient purification process of a 5-hydroxymethylthiazole medical intermediate. The preparation method comprises the following steps: S1, mixing a crude product of 5-hydroxymethylthiazole with liquid caustic soda, heating, preserving heat and stirring to prepare a sodium salt solution of 5-hydroxymethylthiazole; s2, adding a complexing agent, and filtering to remove solids; s3, oxalic acid is added into the filtrate for acidification, the temperature is kept at 55-65 DEG C during acidification, and a decolorizing flocculant is added in the acidification process to prepare a suspension; and S4, cooling the suspension treated in the step 3) to 20-30 DEG C, carrying out solid-liquid separation, and carrying out rotary evaporation crystallization on the obtained liquid to obtain the 5-hydroxymethylthiazole. The process has the advantages of few steps, mild conditions, good purification effect and low ...
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