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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 49. Отображено 49.
06-07-2016 дата публикации

Mold cooling water control system

Номер: CN0205362631U
Принадлежит:

... 本专利申请公开了一种可根据压铸机的工作状态实时调节冷却水流量的模具冷却水控制系统。模具冷却水控制系统,包括显示器中的模具导热系数设定模块和模具冷却水开闭条件设定模块,PLC控制器中的冷却水开通时间计算模块、压铸机工作状态检测模块以及根据压铸机工作状态数据进行的比较模块,比较模块根据比较结果控制冷却水的流量。 ...

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15-06-2017 дата публикации

USE OF AGONIST OF STIMULATOR OF INTERFERON GENES IN TREATING ALZHEIMER'S DISEASE

Номер: WO2017096963A1
Принадлежит:

The present invention discloses a use in which an agonist, cGAMP, of key target proteins, stimulator of interferon genes (STING), in the existing immune pathway, and its derivatives are used in preparing a drug of a neurodegenerative disease such as Alzheimer's disease (AD). The STING agonist can improve cognitive function of AD model rats, suppress neuronal apoptosis of AD rats, suppress amyloidosis of cranial nerves of AD rats, lower a total count of immune microglia in brains of AD rats, reduce inflammation in brains of AD rats, and prevent progression of AD.

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11-10-2018 дата публикации

ELECTRICAL OR OPTICAL CABLE EASILY IDENTIFIABLE UNDER BRIGHT AND DARK LIGHT CONDITIONS AND MANUFACTURING METHOD THEREOF

Номер: WO2018184349A1
Автор: YUAN, Hong
Принадлежит:

The present technical solution relates to the technical fields of optical and electrical cables, and power and communication constructions, in particular relates to an electrical or optical cable easily identifiable under bright and dark light conditions, the cable comprising an electrical or optical cable core (1), a protection layer (2) surrounding the electrical or optical cable core (1), and a sheath layer (3) extruded on and surrounding the protection layer (2), wherein the sheath layer (3) has at least one sheath groove (31) on the periphery thereof; the sheath groove (31) has a luminous unit (4) therein, and the sheath layer (3) and the luminous unit (4) are surrounded by a transparent light-transmitting strip (5); the luminous unit (4) is a linear or strip-like structure that can emit visible light after absorbing visible light. The present technical solution mainly has the following beneficial technical effects: the reduced investment in an extrusion apparatus for identification ...

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08-06-2016 дата публикации

Floor back end behind car

Номер: CN0205292818U
Автор: YUAN HONG, PENG BIN
Принадлежит:

... 本实用新型公开种汽车后地板后段,包括后地板后段本体,所述后地板后段本体由支撑主板连接翻边形成,所述支撑主板中部连接有U型的连接板,所述U型连接板包括第连接板和第二连接板,所述第二连接板的边缘连接有底盘,所述第连接板、第二连接板和底盘连接形成个下凹的备胎盆,并且与U型连接板开口方向相反的支撑主板上设有第加强槽,所述第加强槽的两侧分别设有两个长度相等的第二加强槽,所述第加强槽和第二加强槽中分别设有加强筋,当车身发生碰撞时,后地板后段上的第加强槽和第二加强槽,以及设置在槽内的加强筋可以横纵方向传播分散碰撞产生的力,提高车身整体刚度和强度,保障车内乘员的安全。 ...

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06-07-2016 дата публикации

Badminton exercise device

Номер: CN0205360500U
Автор: YAN LISHA, LI ZHUO, YUAN HONG
Принадлежит:

... 一种羽毛球练习装置,涉及羽毛球训练设备领域,包括主体和支架,支架共有两个,主体通过其两侧的旋转轴安装在支架上,主体的正面设置有一组同心的环形隔板,相邻的两个环形隔板之间形成的环形空间被小隔板分隔成用于容纳单个羽毛球的小格,主体的背面设置有活动门,活动门铰接在主体上。本实用新型设置了放射状分布的多组容纳羽毛球的小格,练习时,练习者在一定距离外朝着本装置主体的中心发球,理想状态下,球会落入中心的圆孔内,但由于偏差的存在,更多的球会偏离中心,落入其它小格。一组训练过后,通过统计落入各组小格的球数,便可以量化评价球路的准确度这一指标。 ...

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08-06-2016 дата публикации

Skylight beaded finish

Номер: CN0205292235U
Автор: YUAN HONG, PENG BIN
Принадлежит:

... 本实用新型公开了种天窗加强环,包括天窗加强环本体;天窗加强环本体上具有天窗滑面和内腔;天窗滑面上设有至少个与内腔相连通的通道口;天窗加强环本体上还设有与内腔相配合的盖子。本实用新型的天窗加强环本体用于配合天窗使用,打开盖子,然后露出内腔,沿内腔相连通的连通孔放入根管子,直到管子伸出端刚好从天窗滑面处露出,然后再向管子里注入润滑剂,在注入润滑剂的过程中,可以控制天窗来回开和关达到润滑的作用,结构简单,实用性强。 ...

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23-06-2023 дата публикации

Intelligent light indication system and method

Номер: CN116321598A
Принадлежит:

The invention discloses an intelligent light indication system and method. The intelligent light indication system comprises a central control platform, a plurality of lamps arranged at all positions of an airport, a converged communication gateway and wireless positioning beacon equipment. The lamp serves as a wireless positioning base station, so that the accurate position of a vehicle or a person can be judged conveniently, wireless control is carried out through the center control platform, corresponding guiding work is carried out through the light effect, and compared with existing monotonous light, the guiding effect can be greatly improved, and the guiding efficiency is improved. And the guidance effect can be customized according to different requirements, so that the guidance effect can be distinguished from the guidance effect of other personnel or vehicles, the confusion condition is avoided, and the effectiveness of light guidance is improved.

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08-06-2016 дата публикации

Top cap is strengthened to car

Номер: CN0205292236U
Автор: YUAN HONG, PENG BIN
Принадлежит:

... 本实用新型公开了种汽车加强顶盖。汽车加强顶盖包括顶盖本体,顶盖本体端的宽度大于另端的宽度,顶盖本体上设有长方形的天窗开口,天窗开口相邻的边之间圆滑过渡,天窗开口的四周均设有卷边,顶盖本体的轮廓均设有用于与车身相固定的固定部,顶盖本体的下表面设有若干加强片,加强片分别沿第方向和第二方向排列并交互形成若干菱形,且沿第方向和第二方向还排列有加厚加强片,加厚加强片之间间隔有定数量的加强片,每加厚加强片上设有若干U型开口。本实用新型在车顶盖的底面设有两个方向的加强片,能够加强车顶盖的受力强度,设计合理,由于加厚加强片的隔开,产生了定的空间,所以还具有定的隔热效果。 ...

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28-09-2017 дата публикации

APPLICATION OF CYCLIC DINUCLEOTIDE CGAMP-LIPOSOME FOR RESISTING TUMOURS

Номер: WO2017162055A1
Принадлежит:

Disclosed in the present invention is an application of a liposome-encapsulated cyclic dinucleotide cGAMP for resisting tumours.

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22-06-2016 дата публикации

Luggage compartment floor

Номер: CN0205327188U
Автор: YUAN HONG, PENG BIN
Принадлежит:

... 本实用新型公开了一种行李舱地板,包括板体(1),所述板体(1)呈矩形,所述板体(1)的前端和后端均设有竖直向上弯折的第一翻边块(21),所述板体(1)的左端和右端均设有一段竖直向上弯折的第二翻边块(22);该板体(1)的中部设有下凹的凹槽(11),在所述凹槽(11)的中部设有至少一个第一加强筋(31),该凹槽(11)槽底的边沿处设有至少一个第二加强筋(32)。本实用新型在中部设有凹槽,并在凹槽的槽底设置多个加强筋,在不影响美观的前提下提高了地板受力强度和空间使用率,同时在一定程度上满足了汽车轻量化的要求。 ...

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01-08-2023 дата публикации

Wire stripping machine with positioning and deviation rectifying functions

Номер: CN116526380A
Автор: YUAN HONG, ZHANG XU, YU LANYI, LI KE
Принадлежит:

The invention discloses a wire stripping machine with positioning and deviation rectifying functions, which belongs to the technical field of wire stripping machines, and is technically characterized by comprising a transmission assembly, an intermittent assembly, a mounting assembly and an adjusting assembly. When the electric wire body is peeled, the electric wire body is placed on the transmission assembly, the transmission assembly is started, and the transmission assembly can drive the electric wire body to intermittently rotate through connection with the intermittent assembly, so that the electric wire body can be peeled under the action of the peeling knife. When the wire body is in transmission, the guide assembly can rectify the deviation of the wire body under the action of the deviation rectifying assembly. When the peeling angle of the peeling knife needs to be adjusted, the adjusting assembly only needs to be rotated reversely, so that the mounting assembly can rotate under ...

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23-05-2023 дата публикации

Application of reagent for overexpressing HS3ST5 gene in promotion of virus infection and recombinant CHO-K1 cell line

Номер: CN116144707A
Принадлежит:

The invention provides application of a reagent for overexpressing an HS3ST5 gene in promotion of virus infection and a recombinant CHO-K1 cell line constructed by the reagent, and belongs to the technical field of gene engineering. The invention provides a recombinant CHO-K1 cell line for expressing HS3ST5, which is obtained by cloning an HS3ST5 fragment into a lentiviral vector to construct a recombinant lentiviral plasmid, and then infecting CHO-K1 cells with lentivirus which is packaged by virus rescue to obtain the recombinant CHO-K1 cell line for expressing HS3ST5. The recombinant CHO-K1 cell capable of stably expressing the HS3ST5 can promote adsorption, internalization, gene replication and generation of filial generation viruses of FMDV, so that a tool is provided for researching a virus pathogenic mechanism, and a basis is provided for subsequently preparing a virus infection cell model.

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11-10-2018 дата публикации

SELF-LUMINOUS AND EASILY IDENTIFIABLE CABLE AND MANUFACTURING METHOD THEREOF

Номер: WO2018184365A1
Автор: YUAN, Hong
Принадлежит:

A self-luminous and easily identifiable cable and manufacturing method thereof. The cable comprises an electrical or optical cable core (1), and a protection layer (2) disposed outside the electrical or optical cable core (1). The protection layer (2) has a continuous spiral groove (3) on a surface thereof. A luminous string (41) is provided in the spiral groove (3) and does not protrude from the surface of the protection layer (2). A transparent light-emitting strip (5) is provided outside the protection layer (2) and surrounds the spiral groove (3) and the protection layer (2). A distance (L) between the centers of adjacent grooves (3) of the spiral groove (3) is 3-10 times the diameter of the electrical or optical cable. The electrical or optical cable core (1) comprises at least one power wire for power transmission, or at least one optical fiber for signal transmission, or at least one lead containing metals for signal transmission. The self-luminous and easily identifiable cable is ...

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12-05-2023 дата публикации

Airport intruded runway monitoring off-line early warning system and method

Номер: CN116112905A
Принадлежит:

The invention discloses an airport intruded runway monitoring off-line early warning system and method. In the operation process of behavior subjects such as vehicles and personnel, a converged communication terminal equipped for each behavior subject is provided with an intelligent operation processing storage assembly, a display assembly, an LORA local area network communication assembly and the like; a communication terminal receives positioning information and differential data of a communication base station by means of a built-in component, and an intelligent operation processing storage component calculates high-precision positioning information of the terminal by using an algorithm, and performs conformity operation on the high-precision positioning information, a prefabricated high-precision map and electronic fence information. Different degrees of runway approaching states of behavior subjects such as vehicles and personnel are calculated, prompting, early warning and warning ...

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21-11-2019 дата публикации

PARTIAL GLYCERIDE LIPASE MUTANT AND APPLICATION THEREOF

Номер: WO2019218598A1
Принадлежит:

Provided is a partial glyceride lipase mutant obtained by means of the site-directed mutagenesis of a partial glyceride lipase derived from penicillium. One or more following mutation modes are adopted for a mutation site of the partial glyceride lipase: (1) tyrosine at the 84-th site of the protein is mutated to arginine; (2) methionine at the 209-th site of the protein is mutated to alanine; and (3) isoleucine at the 260-th site of the protein is mutated to glutamic acid or arginine. By means of the mutant, the thermal stability and hydrogen peroxide tolerance of partial glyceride lipase are greatly improved. Compared with a wild partial glyceride lipase, the mutant has significantly improved capability of catalyzing esters to be subjected to an epoxidation reaction, and the yield of target products is high.

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08-06-2016 дата публикации

Back floor

Номер: CN0205292817U
Автор: YUAN HONG, PENG BIN
Принадлежит:

... 本实用新型公开了种后地板,包括前平段(1)、后斜段(2)和后平段(3),所述前平段(1)的后端与后斜段(2)的下端连接,所述后斜段(2)与后平段(3)之间设有上斜段(4),该上斜段(4)的下端与后斜段(2)的上端连接,所述上斜段的上端与后平段(3)前端连接;在所述前平段(1)后端的左、右两端对称设有两个斜向后设置的圆弧段(6);在所述前平段(1)后端的中部左、右对称设有两个座椅安装槽(5)。本实用新型设置斜段和平段,增加了结构的层次,能分担和减小受力变形,加强筋和凸台等的设置合理,可以减轻整车重量,降低油耗、并能提高汽车后部NVH性能。 ...

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20-06-2019 дата публикации

ELECTRICALLY OPERATED VALVE

Номер: WO2019114613A1
Принадлежит:

Disclosed is an electrically operated valve capable of quickly achieving reliable switching between multiple flow paths, the electrically operated valve comprising a driving mechanism, an executing mechanism and a valve body assembly, wherein the driving mechanism comprises a bushing (53) and an output shaft (51) located in the bushing (53), the executing mechanism comprises a valve stem (1) connected to the output shaft (51) and a valve core (2) connected to the valve stem (1), and the valve core (2) is provided with a first flow channel (21) and a second flow channel (24); the valve body assembly comprises a valve body (3) and a valve seat (4), the bushing (53) is fixed to the valve body assembly in a sealed manner and forms a space isolated from the outside, the output shaft (51) and a connecting portion between the valve stem (1) and the output shaft (51) are located in this space, the valve stem (1) is not connected to the outside, the valve body (3) has a cavity (31), four through ...

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23-08-2018 дата публикации

COMPOSITE CLADDING FOR USE WITH ELECTRICAL CABLE OR OPTICAL CABLE

Номер: WO2018149313A1
Автор: YUAN, Hong
Принадлежит:

The invention relates to the field of new materials, and specifically, to a composite cladding for use with an electrical cable or an optical cable. The composite cladding comprises a rectangular solid base strip, and is characterized in that the composite cladding further comprises a plurality of separation components. When in use, a first snap-fit unit of one of the separation components protrudes out of an upper surface of a base strip main body. The invention resolves technical issues in the prior art of unclear color separation and an inaccurate size owing to a colored cable colored strip and a base material being mixed with each other. The invention has the following preferred technical effects: being simple in structure, smart in design, low in cost and easy to manufacture, having a clearly defined color border on a produced color cable, having no color mixing between adjacent color strips, and achieving higher compatibility.

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03-05-2018 дата публикации

CONTROL DEVICE FOR PREVENTING AUTOMOBILE FROM ESCAPING

Номер: WO2018076422A1
Автор: YUAN, Hong
Принадлежит:

A control device for preventing an automobile from escaping. The control device for preventing an automobile from escaping comprises a front fixed seat (1) and a rear fixed seat (2). The front fixed seat (1) is provided with a groove (4). The front fixed seat (1) and the rear fixed seat (2) are connected to each other by means of a fixed member (3). The rear fixed seat (2) is also provided with a buffering airbag (6). A steel wire rope (5) is connected in front of the front fixed seat (1) and the rear fixed seat (2). As wheels are not in contact with the ground, the automobile loses advancing power when running on the steel wire rope; and after the automobile is gradually decelerated, violent criminals can be caught; meanwhile, as the steel wire rope (5) is also connected to a resistance device located in the rear fixed seat (2), the gravity and inertia of the automobile are converted into positive pressure to the ground by means of the device, so as to increase the resistance and provide ...

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23-08-2018 дата публикации

COLOR ALTERNATING ELECTRICAL CABLE OR OPTICAL CABLE

Номер: WO2018149314A1
Автор: YUAN, Hong
Принадлежит:

The invention relates to the field of cables and power communications, and in particular, to a color alternating electrical cable or optical cable. The color alternating electrical cable or optical cable comprises a protective tube (6) surrounding an electrical cable or optical cable core (7), a composite cladding located outside the protective tube, a first protective layer (4) located outside the composite cladding, and a second protective layer located (5) outside the first protective layer. The composite cladding comprises a rectangular solid base strip (2) and a plurality of separation components (1). Each of the separation components comprises a first snap-fit unit (11) and a second snap-fit unit (12). When in use, the first snap-fit unit of each of the separation components protrudes out of an upper surface of a base strip main body. The color alternating electrical cable or optical cable can be used to resolve technical issues in the prior art of unclear color separation and inaccurate ...

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03-05-2018 дата публикации

METHOD FOR MANUFACTURING HIGH-STRENGTH AND LOW-WEIGHT PHOTOELECTRIC CABLE FOR AVIATION

Номер: WO2018076686A1
Автор: YUAN, Hong
Принадлежит:

A method for manufacturing a high-strength and low-weight photoelectric cable for aviation, relating to the technical field of aviation materials and a photoelectric composite cable. The method comprises the following steps: a step of paying out an optical fiber, a step of forming an inner conductor; a step of forming an inner insulation layer; a step of forming an outer conductor; a step of forming an outer insulation layer; and a step of forming an anti-stretching protective sleeve layer. Also disclosed are the structure of the photoelectric cable and special materials of the inner and outer conductors. The photoelectric cable has the following beneficial technical effects: light weight, small outside diameter, big tensile strength, good heat resistance, strong twisting resistance, easy manufacture, and high yield of finished product.

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08-06-2016 дата публикации

Preceding crashproof roof beam inner panel

Номер: CN0205292516U
Автор: YUAN HONG, PENG BIN
Принадлежит:

... 本实用新型公开了种前防撞梁内板,包括板体(1),所述板体(1)为左、右两端低中间高的拱形结构,在所述板体(1)的上、下两侧的边沿均设有向后延伸的翻折段(11),下侧的所述翻折段(11)左、右对称设有两个锥形开口槽(3),该板体(1)的中部设有开口向前的第凹槽(12),在所述第凹槽(12)的中部还设有开口向前的第二凹槽(13),在所述第二凹槽(13)槽底的中部设有向前凸出的凸台(21);在所述第凹槽(12)的两端对称设有两个固定孔(14)。本实用新型由冲压成型的凹槽、凸台和翻折段,能提高前防撞梁的受撞强度,也能缓冲撞击的回弹力,结构简单,便于生产。 ...

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23-03-2017 дата публикации

APPLICATION OF CYCLIC GMP-AMP (CGAMP) IN COMBINATION WITH BEVACIZUMAB IN TUMOR RESISTANCE

Номер: WO2017045595A1
Принадлежит:

Application of cyclic GMP-AMP (cGAMP) in combination with bevacizumab in tumor resistance. A research shows that combination of cGAMP and bevacizumab can significantly inhibit growth of multiple tumor cells, has an obvious tumor resistance effect, and can be used for preparing antitumor drugs. A model of subcutaneously transplantable tumors in a C57BL/6 mouse shows that the combination of the cGAMP and the bevacizumab has significant inhibition effects on an adenocarcinoma cell line MC38, a lung cancer cell line LLC, melanoma cell lines B16-F10, and a colon cancer cell MC38, and the effects are better than a single medication effect. Therefore, the combination of the cGAMP and the bevacizumab can be used for treating tumors.

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08-06-2016 дата публикации

Water tank entablature reinforcing plate

Номер: CN0205292794U
Автор: YUAN HONG, PENG BIN
Принадлежит:

... 本实用新型公开种水箱上横梁加强板,包括第主板和第二主板,所述第主板的两端分别设有个安装孔,并且两个安装孔之间设有第凸起件,所述第凸起件的中部设有第二凸起件,所述第凸起件和第二凸起件上开设有多个安装孔,所述第主板的侧连接有凸起唇边,另侧与第二主板连接,所述第二主板上开设有安装窗口,所述第二主板中部设有两个连接板,所述第二主板还设有多个加强件以及多个安装孔,此结构构造的水箱上横梁加强板,能有效保护水箱上横梁,而且提高了水箱上横梁强度和抗扭能力,使水箱的使用寿命加长,保障汽车的正常运行使用。 ...

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22-06-2016 дата публикации

Electrocardio props up leads protective sleeve device

Номер: CN0205322498U
Принадлежит:

... 本实用新型公开了一种心电支导保护套装置,包括分支导线、导联线头、导联线套体和输液器节段,所述分支导线的一端连接有导联线头,分支导线靠近导联线头的一端套接有由软塑料制成的导联线套体,所述导联线套体上设有通孔,所述分支导线位于通孔内,所述分支导线的外部套接有输液器节段,输液器节段是由输液器上的软管部分剪截制成。本实用新型不仅使导线不易缠绕且易梳理,减少整理导线的时间,提高工作效率,减轻护理工作量,提高护理服务质量,避免外部硅胶的折断导丝外露给患者带来安全隐患的发生,延长导线的使用寿命,而且本心电支导保护套装置制作简单、成本低,使用时及其方便节省时间,做到废物利用,临床使用范围广。 ...

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06-06-2023 дата публикации

Recombinant BHK-21 cell line of overexpressed HS3ST5 gene and application of recombinant BHK-21 cell line in enhancement of virus replication

Номер: CN116218783A
Принадлежит:

The invention provides a recombinant BHK-21 cell line of an overexpressed HS3ST5 gene and application of the recombinant BHK-21 cell line in enhancement of virus replication, and belongs to the technical field of gene engineering. The invention provides a recombinant BHK-21 cell line overexpressing HS3ST5, which is obtained by cloning an HS3ST5 fragment into a lentiviral vector to construct a recombinant lentiviral plasmid, and then infecting a BHK-21 cell with a lentivirus which is packaged by virus rescue, and the recombinant BHK-21 cell line overexpressing HS3ST5 is obtained. The recombinant BHK-21 cell overexpressing the HS3ST5 can promote adsorption and replication of the FMDV, so that an effective tool is provided for preparation of a virus vaccine antigen, and a foundation is laid for subsequent research on virus infection and prevention and treatment.

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08-06-2016 дата публикации

Floor in car

Номер: CN0205292819U
Автор: YUAN HONG, PENG BIN
Принадлежит:

... 本实用新型提供种汽车中地板,包括前地板连接端和后地板连接端,所述前地板连接端和后地板连接端均设有多个夹具定位孔,所述前地板连接端与后地板连接端通过下凹面连接,所述下凹面外壁与汽车上中地板安装处的外部轮廓相配合,所述下凹面的横截面为圆弧,所述下凹面内壁的两圆弧端设有加强部,所述加强部连接前地板连接端和后地板连接端。由于采用了上述技术方案,本实用新型具有结构简单和合理的优点,汽车中地板,前地板连接端与后地板连接端通过下凹面连接,韧性好,连接前地板连接端和后地板连接端可靠;通过设置加强部连接前地板连接端和后地板连接端,增强结构强度。 ...

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25-04-2023 дата публикации

Quantitative detection kit for 3AB and/or 3ABC non-structural protein in foot-and-mouth disease inactivated vaccine and application

Номер: CN116008541A
Принадлежит:

The invention provides a quantitative detection kit for 3AB and/or 3ABC non-structural protein in a foot-and-mouth disease inactivated vaccine and application of the quantitative detection kit, and belongs to the technical field of vaccine detection. Based on a double-antibody sandwich ELISA (enzyme-linked immunosorbent assay) principle and a biotin-avidin detection system, an FMDVNSP3A monoclonal antibody, a biotin-labeled 3B monoclonal antibody and a foot-and-mouth disease virus non-structural protein 3AB are utilized to construct the detection kit for quantitatively detecting the content of 3AB and 3ABC in the FMD inactivated vaccine. According to the method disclosed by the invention, the condition that the residual quantity of the 3AB and 3ABC non-structural proteins in the foot-and-mouth disease inactivated vaccine does not exceed 5ng/ml is determined to be the qualified evaluation standard of the antigen purity of the foot-and-mouth disease inactivated vaccine. Reference is provided ...

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18-04-2023 дата публикации

Separation and identification method and application of sheep enterovirus

Номер: CN115975952A
Принадлежит:

The invention discloses a separation and identification method and application of a sheep enterovirus, a metagenome sequencing technology is utilized, a CEV whole genome sequence is obtained from Hu sheep tissues dead in a certain farm in China, the CEV whole genome sequence and a CEV genome sequence in a GenBank database are compared and analyzed, and the virus is separated by utilizing a method of transfecting BHK-21 cells by RNA. Carrying out strain separation and identification by using an RT-PCR (Reverse Transcription-Polymerase Chain Reaction) method, gene sequencing and a transmission electron microscope technology, inactivating virus liquid to prepare a vaccine, and immunizing a rabbit to prepare CEV positive serum; the length of the whole genome nucleotide sequence of the CEV measured by a metagenomics method is 7446 nt, the length of 5 'UTR is 821 nt, the length of 3' UTR is 109 nt, the length of ORF is 6516 nt, the nucleotide homology with the published CEV sequence is 75.1%- ...

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08-06-2016 дата публикации

Automobile top cover

Номер: CN0205292808U
Автор: YUAN HONG, PENG BIN
Принадлежит:

... 本实用新型公开了种汽车顶盖,包括顶盖本体(1),在所述顶盖本体(1)上端面的两条对角线方向各设有个条形凹槽(11),在所述顶盖本体(1)上沿轴向平行设有多个第排水槽(12),多个所述第排水槽(12)与两个条形凹槽(11)的对应位置均连接贯通;在所述顶盖本体(1)左、右两端的边沿沿轴向各设有个第二排水槽(13),所述第排水槽(12)和第二排水槽(13)的前、后端均设有开口。本实用新型结构简单,设置多样式相结合的排水槽,提高了车顶雨水的排放效率,减少了车门窗的雨水残留,方便驾驶员观察路况,能提高行车安全性,排水槽所形成的隆起提高了受压强度。 ...

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30-05-2023 дата публикации

HS3ST5 gene knock-down sgRNA and knock-down vector and application thereof

Номер: CN116179546A
Принадлежит:

The invention provides sgRNA for knocking down an HS3ST5 gene as well as a knockdown vector and application of the sgRNA, and belongs to the technical field of gene knockout. According to the invention, sgRNA of a targeted HS3ST5 gene is utilized to construct a recombinant vector for knocking down HS3ST5, and after lentivirus packaging, a BHK-21 cell line is infected to obtain a BHK-21 recombinant cell line for knocking down HS3ST5. Experiments show that the replication capacity and the multiplication capacity of the BHK-21 recombinant cell line after the HS3ST5 is knocked down on FMDV are remarkably reduced. Therefore, the sgRNA capable of stably knocking down the HS3ST5 can be used as an effective tool to be applied to virus infection treatment by using HS as a receptor, and a new thought is provided for virus infection resistance.

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15-06-2016 дата публикации

Skylight beaded finish

Номер: CN0205311305U
Автор: YUAN HONG, PENG BIN
Принадлежит:

... 本实用新型公开了一种天窗加强环。所述天窗加强环包括加强环本体,所述加强环本体上设有天窗开口,所述天窗开口的四周设有包边,所述包边的外侧设有若干分段式挤胶槽,所述加强环本体对称设有用于与顶盖固定的两个第一固定片和两个第二固定片,每一第一固定片上设有两个固定孔,每一第二固定片上设有一个固定孔,所述加强环本体的两端对称设有用于与顶盖焊接的焊接边,所述加强环本体上设有三个用于减轻自重的方孔,所述方孔位于挤胶槽的外侧。本实用新型天窗加强环轻巧,且能减化安装工艺。 ...

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28-04-2023 дата публикации

Tumor immune target spot determination method based on segmentation labeling

Номер: CN116030884A
Принадлежит:

The invention discloses a tumor immune target spot determination method based on segmentation labeling, and the method comprises the steps: taking a gene sequence as a text sequence through an artificial intelligence model based on natural semantic understanding, and carrying out the segmentation labeling of the text sequence to determine the probability that each gene read belongs to a tumor immune target spot, so as to determine the tumor immune target spot in the gene sequence.

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02-05-2023 дата публикации

Airport runway anti-intrusion system and method based on Bluetooth AoA positioning

Номер: CN116056007A
Принадлежит:

The invention discloses an airport runway anti-intrusion system and method based on Bluetooth AoA positioning. The Bluetooth positioning data signals of the Bluetooth positioning beacon equipment in the range are acquired through multi-antenna acquisition of the Bluetooth positioning base station, so that accurate positioning of a signal source is obtained through calculation, and if the signal source, namely, a vehicle or a person intrudes into an airplane runway area, is detected during takeoff and landing of the aircraft, the signal source can be accurately positioned. If yes, real-time feedback is carried out, corresponding vehicles or personnel are notified to conduct emergency braking or be away from the runway range, and therefore safety is ensured. Through the AoA positioning mode, the positioning precision can be improved, the situation that satellite signal receiving is affected by satellite positioning precision and environment shielding in the prior art is avoided, meanwhile ...

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23-05-2023 дата публикации

SiRNA for transient targeted interference of HS3ST5 gene expression and application thereof

Номер: CN116144655A
Принадлежит:

The invention provides siRNA for transient targeted interference of HS3ST5 gene expression and application of the siRNA, and belongs to the technical field of interfering RNA. The invention provides siRNA for transient targeted interference of HS3ST5 gene expression and application of a reagent for targeted interference of the siRNA to HS3ST5 gene expression in preparation of drugs for resisting virus infection. By knocking down the expression of the HS3ST5 gene or protein, the host cell has a reduction effect on the aspects of virus adsorption, internalization, virus gene replication and progeny virus generation, which proves that the resistance of the host cell to virus infection can be improved by silencing the expression of the HS3ST5 gene or reducing the expression of the HS3ST5 protein; therefore, reference is provided for developing novel broad-spectrum antiviral drugs.

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04-04-2023 дата публикации

O-type foot-and-mouth disease vaccine candidate strain as well as construction method and application thereof

Номер: CN115896043A
Принадлежит:

The invention discloses an O-type foot-and-mouth disease vaccine candidate strain as well as a construction method and application thereof, and belongs to the technical field of biological products. The recombinant virus rHN/XJ/SCGH is constructed by utilizing a reverse genetic manipulation technology of a foot and mouth disease virus, taking an infectious clone of a current epidemic strain O/XJ/CHA/2017L + P1 gene of a chimeric foot and mouth disease as a skeleton and further replacing a peer-to-peer gene with a G-H ring gene of a foot and mouth disease virus O/SCGH/CHA/2016 strain. Compared with a parent virus rHN/XJ, the recombinant virus rHN/XJ/SCGH has the advantages that the lesion time of 100% infected cells caused by the recombinant virus rHN/XJ/SCGH is shortened to 12 h, the replication titer is remarkably improved, a pig immunized by the recombinant virus vaccine can generate a high-level and protective cross neutralizing antibody for four pedigree epidemic viruses of the foot-and-mouth ...

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28-07-2023 дата публикации

Optical fiber ribbon optical cable for communication and composite optical fiber ribbon optical cable

Номер: CN116500737A
Принадлежит:

The invention belongs to the technical field of photoelectricity, and discloses an optical fiber ribbon optical cable for communication, which is provided with at least one optical fiber ribbon, the device is characterized by further comprising four assembling parts, each assembling part is composed of a first side column body, a second side column body and a third side column body, and the four assembling parts are spliced to form a closed center cavity and four side column cavities; the optical fiber ribbons are located in the central cavity, and when multiple optical fiber ribbons are arranged, the multiple optical fiber ribbons are distributed in the central cavity in a stacked mode. The invention further discloses the composite optical fiber ribbon optical cable. The optical fiber has the main beneficial technical effects that the structure is simpler, the manufacturing is easier, the storage is more convenient, the fiber core density is higher, and the influence of temperature heating ...

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13-06-2023 дата публикации

ShRNA (short hairpin ribonucleic acid) for silencing HS3ST5 gene expression as well as recombinant lentiviral vector and application thereof

Номер: CN116254264A
Принадлежит:

The invention provides shRNA (short hairpin Ribonucleic Acid) for silencing HS3ST5 gene expression as well as a recombinant lentiviral vector and application thereof, and belongs to the technical field of gene silencing. According to the invention, two shRNAs for silencing HS3ST5 gene expression are designed, recombinant lentivirus plasmids carrying the shRNAs are constructed, a recombinant BHK-21 cell line for knocking down HS3ST5 is established by utilizing packaged recombinant lentivirus, and the result shows that knockdown of HS3ST5 expression level can effectively inhibit virus proliferation. Therefore, the invention provides a new idea for resisting virus infection.

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27-06-2023 дата публикации

Bifunctional inhibitors targeting PD-1 and VEGF

Номер: CN116333155A
Принадлежит:

The invention provides a bifunctional inhibitor simultaneously targeting PD-1 and VEGF, which is an antibody, and the heavy chain of the antibody comprises an amino acid sequence related to the function of inhibiting PD-1 and VEGF. The invention also provides nucleic acid molecules encoding heavy and/or light chains that produce bifunctional inhibitors, constructs carrying the nucleic acid molecules, cells carrying the nucleic acid molecules or the constructs. The present invention also relates to a pharmaceutical composition comprising the bifunctional inhibitor, the nucleic acid molecule, the construct and/or the cell, and uses of the bifunctional inhibitor, the nucleic acid molecule, the construct, the cell and/or the composition in the preparation of drugs for preventing, alleviating, improving or inhibiting diseases or conditions. The bifunctional inhibitor can effectively inhibit the growth of solid tumor and non-solid tumor cells.

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22-06-2016 дата публикации

Multi -functional ECG monitor line protective sleeve device that leads

Номер: CN0205322497U
Принадлежит:

... 本实用新型公开了一种多功能心电监护仪导联线保护套装置,包括各种导联线、保护套本体、棉布、布绳、第一魔术贴、第二魔术贴和绳孔,所述保护套本体包裹在各种导联线的外部,所述保护套本体上设有棉布,棉布的两端缝制有绳孔,所述绳孔内贯穿有布绳,所述棉布的两侧分别设有第一魔术贴和第二魔术贴。所述布绳一端与设置在多功能心电监护仪一侧的凸台连接;本实用新型减少整理各种导联线的时间,提高工作效率,减轻护理工作量,保持床单位的整洁,提高患者满意,提高护理服务质量,避免外部硅胶的折断导丝外露给患者带来安全隐患的发生,减少终末处理时间及终末处理的擦拭时对导线的损害,延长导线的使用寿命。 ...

Подробнее
06-07-2016 дата публикации

Mold spraying system

Номер: CN0205362601U
Принадлежит:

... 本实用新型公开了一种模具喷涂系统,包括PLC控制模块、人机界面、压铸机工作状态输入模块、喷涂机器人模块、模具喷涂流量控制模块和模具冷却水控制模块。人机界面与PLC控制模块单向通信连接,压铸机工作状态输入模块与PLC控制模块单向通信,喷涂机器人模块与PLC控制模块双向通信,模具喷涂流量控制模块与PLC控制模块单向通信,模具冷却水控制模块与PLC控制模块单向通信。该模具喷涂系统能够大幅缩短压铸机由冷态到正常生产状态的时间,最大限度减少不合格产品件数,提高产品合格率,提升生产效率。 ...

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16-05-2023 дата публикации

Doped optical fiber manufacturing system and method for improving SBS threshold value

Номер: CN116119921A
Принадлежит:

The invention discloses a doped optical fiber manufacturing system and method for improving an SBS threshold value, and the system comprises an optical fiber prefabricating unit which comprises an optical fiber prefabricating rod (5) and a heating furnace (6) disposed in the outer circumferential direction of the optical fiber prefabricating rod (5); the magnetostriction unit comprises a cooling pipe (8) and a magnetic field solenoid coil (9) arranged on the outer circumference of the cooling pipe (8) in a sleeving mode; the coating curing unit comprises a coating device (10) and a curing lamp (11), and the fiber diameter measuring unit comprises a first fiber diameter measuring instrument (7) and a second fiber diameter measuring instrument (12). According to the invention, the current value in the corresponding magnetic field solenoid coil (9) is adjusted to change the stress distribution on the doped fiber caused by the deformation of the magnetostrictive composite material, and the ...

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08-06-2016 дата публикации

Bulge in preceding floor

Номер: CN0205292815U
Автор: YUAN HONG, PENG BIN
Принадлежит:

... 本实用新型公开种前地板中鼓包,包括主板本体,主板本体的上端面包括第主板段、第二主板段和第三主板段,第主板段上设有凸起部,第三主板段设有安装区,安装区上开设有安装口,主板本体两边边缘均连接有侧板,侧板垂直于主板本体设置,其中靠近安装区的第三主板段两边边缘与侧板之间均设有加强件,侧板另端均连接有翻边,其中侧侧板与翻边之间设有部分连接板,翻边平行于地面设置,所述主板本体、侧板、连接板和翻边连接形成个截面为“几”字型的前地板中鼓包,并且纵向上为从端向另端截面逐渐增大的变截面结构,此结构前地板中鼓包可以加强车身刚度和强度,当车身发生碰撞时传递和分散冲击能量,保障车内乘员的生命安全。 ...

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15-06-2016 дата публикации

Tail gate planking

Номер: CN0205311302U
Автор: YUAN HONG, PENG BIN
Принадлежит:

... 本实用新型公开了后车门外板,包括后车门外板本体,所述后车门外板本体与后车门上的内板结合,所述后车门外板本体设有窗框部、门把手部和拱形部,所述窗框部周围设有多条缓冲带。本实用新型所述后车门外板本体与后车门上的内板结合然后安装在车上作为车后门使用,当车窗与后车门外板产生相对运动时,通过所述窗框部周围设有多条缓冲带来减少伤害,实用性强。 ...

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08-06-2016 дата публикации

Automobile front floor

Номер: CN0205292816U
Автор: YUAN HONG, PENG BIN
Принадлежит:

... 本实用新型公开了种汽车前地板,包括地板本体(1),所述地板本体(1)的中部设有凸起的中央通道(2),在所述地板本体(1)的前端斜向下延伸形成弯曲段(11),在所述地板本体(1)上设有下凹的第弧面(31)、第二弧面(32)、第三弧面(34)、第四弧面(37)和第五弧面(35)以及第加强筋(33)、第二加强筋(36),在所述地板本体(1)的后端设有两段上凹的阶梯凸台(4)。本实用新型中设置上凸的中央通道可以起到车身纵梁的作用,能分散撞击力,同时提高了刚度和承重强度,设置的三个弧面能起到减振降噪的作用,多个加强筋有利于提高对应部位的强度和刚度,提高乘坐舒适性,结构简单,装配便捷。 ...

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01-08-2023 дата публикации

Anti-SIRP alpha antibody and application thereof

Номер: CN116514980A
Принадлежит:

The invention discloses an anti-SIRP alpha antibody and application thereof, the anti-SIRP alpha antibody comprises a first antibody or a second antibody or a third antibody, the first antibody comprises three first heavy chain CDR regions and three first light chain CDR regions; the three first heavy chain CDR regions comprise an amino acid sequence HCDR1 as shown in SEQ ID NO.1, an amino acid sequence HCDR2 as shown in SEQ ID NO.2, and an amino acid sequence HCDR3 as shown in SEQ ID NO.3; the three first light chain CDR regions comprise an amino acid sequence LCDR1 as shown in SEQ ID NO.4, an amino acid sequence LCDR2 as shown in SEQ ID NO.5 and an amino acid sequence LCDR3 as shown in SEQ ID NO.6; according to the present invention, the CD47 and SIRP alpha signal channel can be effectively blocked, the phagocytosis of macrophages can be promoted, and the application can be used for the treatment of colorectal cancer patients.

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27-07-2016 дата публикации

Ankle pump athletic training device

Номер: CN0205391600U
Принадлежит:

... 本实用新型公开了踝泵运动训练装置,包括用于套设在脚部的第脚套(1)和套设在小腿部的第二脚套(2),所述第脚套(1)和所述第二脚套(2)之间连接有弹簧装置(3),所述第二脚套(2)上设有训练定时提醒装置(4),所述训练定时提醒装置(4)包括单片机(4?1)、传感器(4?2)、时间继电器(4?3)和蜂鸣器(4?4),所述传感器(4?2)的信号输出端与所述单片机(4?1)的信号输入端连接,所述单片机(4?1)的信号输出端与所述时间继电器(4?3)的信号输入端连接,所述时间继电器(4?3)的信号输出端与所述蜂鸣器(4?4)连接。本实用新型提供的踝泵运动训练装置,能够定时提醒患者做踝泵运动,促进患者术后创伤部位的恢复并预防深静脉血栓的发生。 ...

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11-04-2023 дата публикации

Magnetic flux quasi-isentropic loading low-temperature sample experimental device and method thereof

Номер: CN115950725A
Принадлежит:

The invention discloses a magnetic flux quasi-isentropic loading low-temperature sample experimental device and a method thereof, and belongs to the technical field of high-pressure physical magnetic flux quasi-isentropic loading. According to the experimental device, a sample target cavity is coaxially arranged in an explosion magnetic flux loading device, and a low-temperature cold source fixed sealing plate is arranged on the explosion magnetic flux loading device for sealing; the refrigeration cold head is arranged above the explosion magnetic flux loading device and is connected with the sample target cavity through a heat conduction material; the vacuum cover is arranged above the refrigerating cold head in a covering mode. According to the magnetic flux quasi-isentropic loading low-temperature sample experiment device, the design that the refrigeration cold head serves as a sample target cavity cooling cold source is adopted, use of low-temperature working media in an experiment ...

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05-05-2023 дата публикации

Chog cholera virus tubular chemiluminiscence antibody detection kit based on E2 protein dimer and application of hog cholera virus tubular chemiluminiscence antibody detection kit

Номер: CN116068175A
Принадлежит:

The invention provides an E2 protein dimer-based hog cholera virus tubular chemiluminescent antibody detection kit and application thereof, and belongs to the technical field of in-vitro diagnostic products. The kit provided by the invention comprises a hog cholera virus tubular chemiluminescence antibody detection reaction system, wherein a magnetic particle suspension contained in the hog cholera virus tubular chemiluminescence antibody detection reaction system contains magnetic particle coupled hog cholera virus E2 dimer protein. Compared with a kit prepared from hog cholera virus E2 monomer protein and a commercial ELISA detection kit, the kit provided by the invention not only can accurately and quantitatively detect the specific antibody of hog cholera virus in porcine serum, but also has the characteristics of automation, high sensitivity and high repeatability, and has higher market competitiveness.

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