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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 3. Отображено 3.
21-07-2023 дата публикации

ROS (reactive oxygen species) response type protein cross-linked liposome and application thereof

Номер: CN116459345A
Автор: ZHANG CAN, JU CAOYUN, CHEN JIAQI, XUE LINGJING
Принадлежит:

The invention discloses an ROS (reactive oxygen species) response type protein cross-linked liposome and application of the ROS response type protein cross-linked liposome. The protein cross-linked liposome is a co-delivery system formed by cross-linking a protein drug which is electrostatically adsorbed on the surface of a drug-loaded liposome by using an ROS response type cross-linking agent. According to the delivery system, common loading of protein drugs and small molecule drugs with different physicochemical properties can be realized; in addition, ROS in a tumor microenvironment can be responded to controllably release protein drugs, the curative effect of the protein drugs is improved, and toxic and side effects caused by whole-body distribution of the protein drugs are avoided; at the same time, the liposome can also play a synergistic anti-tumor role with small molecular drugs loaded in the liposome. The invention provides a novel ROS (reactive oxygen species) response type cross-linking ...

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Номер записи: 1
21-04-2023 дата публикации

Neutrophil extracellular vesicle gene delivery system and application thereof in osteoarthritis treatment

Номер: CN115990273A
Автор: ZHANG CAN, JU CAOYUN, CHEN YIJUN, XUE LINGJING
Принадлежит:

The invention relates to a neutrophil extracellular vesicle gene delivery system and application thereof in osteoarthritis treatment. The extracellular vesicle gene delivery system disclosed by the invention is constructed by taking high-activity and high-purity neutrophil extracellular vesicles as a gene drug carrier and loading a gene drug by utilizing an electroporation method. The delivery system can utilize the natural cartilage cell targeting ability of the neutrophil extracellular vesicles to improve the retention ability of gene drugs in joints and the cartilage cell delivery efficiency, so that the gene therapy effect is improved; the proinflammatory action of the neutrophils can be avoided, and the neutrophils can be cooperated with gene medicines to treat the osteoarthritis, so that the treatment effect on the osteoarthritis is finally improved. The problems that an existing gene delivery carrier is poor in bone joint retention capacity and poor in cartilage cell targeting delivery ...

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Номер записи: 2
18-04-2023 дата публикации

Liposome compound for inhibiting Rapsyn gene expression and application thereof

Номер: CN115969791A
Автор: CHEN YIJUN, ZHANG CAN, SUN YANZI, JU CAOYUN, HUANG YINGSHUANG, LIU CHUNYAN
Принадлежит:

The invention relates to the technical field of gene therapy drugs, in particular to a nucleic acid liposome compound capable of targeting leukemia cell load to inhibit Rapsyn gene expression and application of the nucleic acid liposome compound in preparation of drugs for preventing and treating leukemia. The lipidosome compound provided by the invention has a target head DSPE-PEG2000-scFv, can selectively target CD79b < + > leukemia cells, effectively delivers a siRapsyn sequence into the leukemia cells without being degraded by nuclease, enables loaded siRNA to enter cytoplasm, inhibits Rapsyn gene expression, has higher bioavailability and safety, and can be applied to preparation of drugs for treating leukemia. Proliferation of leukemia cells and tumor formation can be effectively inhibited, the lifetime of a leukemia animal model is prolonged, and the purpose of treating leukemia is achieved. The invention provides a new choice for drugs for treating leukemia.

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Номер записи: 3