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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Применить Всего найдено 14. Отображено 14.
04-04-2019 дата публикации

NOVEL METHOD FOR PREPARING (2R)-2-(2-METHOXYPHENYL)-2-(OXANE-4-YLOXY)ETHANE-1-OL COMPOUND, AND INTERMEDIATE USED THEREIN

Номер: WO2019066467A1
Автор: JANG, Wook, BAEK, Jong Ouk, KIM, Hee Cheol, HA, Tae Hee
Принадлежит:

Provided in the present invention are: a novel method for preparing a compound of chemical formula 1, comprising a step of obtaining a compound of chemical formula 1 by performing a reduction reaction on a compound of chemical formula 2; and an intermediate used therein. According to the preparation method of the present invention, the compound of chemical formula 1, which is useful for the production of an acetyl-CoA carboxylase (ACC) inhibitor, can be mass-produced more simply and efficiently than that of a conventional method.

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Номер записи: 1
08-10-2015 дата публикации

4,5-DIHYDRO-1H-PYRAZOL-3-CARBOXIMIDAMIDE DERIVATIVE CONTAINING SULFUR FUNCTIONAL GROUP, PRODUCING METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Номер: KR1020150113762A
Автор: HONG, DONG JIN, BAEK, JONG OUK, OH, HEE SOOK, LEE, MOON SUB, HA, TAE HEE, SUH, KWEE HYUN
Принадлежит:

The present invention relates to a 4,5-dihydro-1H-pyrazole-1-carboximidamide derivative containing sulfur which exhibits an inverse agonist or antagonistic activity of a cannabinoid receptor (CB1) or a pharmaceutically acceptable salt thereof, a producing method thereof and a pharmaceutical composition comprising the same. The compound according to the present invention has fewer side effects due to having excellent peripheral tissue selectivity and exhibits antagonistic activity of a cannabinoid receptor and thus can be used for preventing or treating obesity or obesity-related metabolic diseases. COPYRIGHT KIPO 2016 (AA) Weight change(%) (BB) Day (CC) Vehicle (DD) Rimonabant (EE) Example 1 ...

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Номер записи: 2
30-11-2017 дата публикации

싸이에노피리미딘 화합물의 신규 제조방법 및 이에 사용되는 중간체

Номер: KR0101803499B1
Автор: 백종욱, 정재혁, 김호석, 하태희, 서귀현
Принадлежит: 한미약품 주식회사

... 본 발명은 타이로신 카이네이즈(tyrosine kinase), 특히 변이성 상피세포 성장인자 수용체(mutant epidermal growth factor receptor) 타이로신 카이네이즈를 선택적으로 억제하는 활성을 갖는 하기 화학식 1의 싸이에노피리미딘 유도체의 신규한 제조방법 및 이에 사용되는 신규한 중간체에 관한 것이다. [화학식 1] ...

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Номер записи: 3
07-04-2016 дата публикации

NOVEL PREPARATION METHOD OF NOVEL THIOXO FUROPYRIMIDINONE DERIVATIVES AND INTERMEDIATE PRODUCT USED THERETO

Номер: KR1020160038622A
Автор: BAEK, JONG OUK, OH, HEE SOOK, JANG, SUN YOUNG, HA, TAE HEE, SUH, KWEE HYUN
Принадлежит:

The present invention relates to a preparation method of 2-thioxo furopyrimidin-4-one represented by chemical formula 1 and an intermediate product used thereto. More particularly, the preparation method of the present invention obtains a thiourea carboxylate derivative represented by chemical formula 2 by having a reaction of a compound represented by chemical formula a with benzoyl isothiocyanate, and obtains the 2-thioxo furopyrimidin-4-one represented by chemical formula 1 by having a cyclization reaction of the compound represented by chemical formula 2 in presence of a base. The compound represented by chemical formula 1 can be useful as an intermediate product in preparing a medicine such as an anticancer drug, or the like. COPYRIGHT KIPO 2016 ...

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Номер записи: 4
09-08-2018 дата публикации

싸이에노피리미딘 화합물의 결정형

Номер: KR1020180089904A
Автор: 정재혁, 백종욱, 정선영, 곽은주, 김희철, 하태희
Принадлежит:

... 본 발명은 N-(3-(2-(4-(4-메틸피페라진-1-일)페닐아미노)싸이에노[3,2-d]피리미딘-4-일옥시)페닐)아크릴아미드의 결정형 및 이를 포함하는 약학적 조성물에 관한 것이다. 상기 결정형은 이를 활성성분으로서 포함하는 약학적 조성물의 제조에 용이하게 사용될 수 있다.

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Номер записи: 5
05-07-2018 дата публикации

NOVEL METHOD FOR PREPARING THIENOPYRIMIDINE COMPOUND AND INTERMEDIATE

Номер: WO2018124644A1
Автор: KIM, Hee Cheol, HA, Tae Hee, SUH, Kwee Hyun
Принадлежит:

The present invention relates to a novel method for preparing a thienopyrimidine compound having activities of selectively inhibiting tyrosine kinase, particularly mutant epidermal growth factor receptor tyrosine kinase, and a novel intermediate used therefor. The present invention can industrially mass-produce, more simply and efficiently than the prior art, a compound of formula (1), which is useful as a therapeutic agent for non-small cell lung cancer induced by mutant epidermal growth factor receptor tyrosine kinase.

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Номер записи: 6
07-04-2016 дата публикации

NOVEL PREPARATION METHOD OF NOVEL THIOXO THIENOPYRIMIDINONE DERIVATIVE AND INTERMEDIATE PRODUCT USED THERETO

Номер: KR1020160038615A
Автор: BAEK, JONG OUK, JUNG, JAE HYUK, KIM, HEE CHEOL, HA, TAE HEE, SUH, KWEE HYUN
Принадлежит:

The present invention relates to a preparation method of 2-thioxo thienopyrimidin-4-one represented by chemical formula 1, and an intermediate product used thereto. The preparation method of the present invention comprises the steps of: having a reaction of a compound represented by chemical formula a with benzoyl isothiocyanate; obtaining a thiourea carboxylate derivative represented by chemical formula 2; and having a cyclization reaction of the obtained compound represented by chemical 2 in presence of a base. The compound represented by chemical formula 1 can be used as a useful intermediate product in preparing a medicine such as an anticancer drug, or the like. COPYRIGHT KIPO 2016 ...

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Номер записи: 7
29-01-2016 дата публикации

NOVEL FUSED PYRIMIDINE DERIVATIVES FOR INHIBITION OF TYROSINE KINASE ACTIVITY

Номер: KR0101589114B1
Автор: 차미영, 강석종, 김미라, 이주연, 전지영, 조명기, 곽은주, 이광옥, 하태희, 서귀현, 김맹섭
Принадлежит: 한미사이언스 주식회사

... 본 발명은 타이로신 카이네이즈 활성 억제 효과를 갖는 신규 융합 피리미딘 유도체에 관한 것으로, 본 발명의 신규 화합물을 활성성분으로 함유하는 약학 조성물은 암, 종양, 염증성 질환, 자가면역 질환 또는 면역학적으로 매개된 질환을 치료하거나 예방하는 효과를 제공한다.

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Номер записи: 8
04-07-2018 дата публикации

NOVEL PRODUCTION METHOD FOR PREPARING THIENOPYRIMIDINE COMPOUND AND INTERMEDIATE THEREOF

Номер: KR1020180075228A
Автор: KIM HEE CHEOL, HA TAE HEE, SUH KWEE HYUN
Принадлежит:

The present invention relates to a novel production method of a thienopyrimidine compound which has an activity of selectively inhibiting tyrosine kinase, particularly mutant epithelial cell growth factor receptor tyrosine kinase; and to a new intermediate used in the method. According to the method of the present invention, a compound represented by chemical formula 1 which is useful as a therapeutic agent for non-small cell lung cancer induced by mutant epithelial cell growth factor receptor tyrosine kinase, can be industrially mass-produced more easily and efficiently than the prior art. COPYRIGHT KIPO 2018 ...

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Номер записи: 9
23-08-2016 дата публикации

카나비노이드 CB1 수용체 길항제로서의 1,5-디아릴-4,5-디하이드로-1H-피라졸-3-카복스아미딘 유도체, 이의 제조방법 및 이를 포함하는 약학 조성물

Номер: KR0101650402B1
Автор: 이문섭, 홍동진, 오희숙, 백종욱, 정영희, 김남두, 하태희, 서귀현
Принадлежит: 한미약품 주식회사

... 본 발명은 카나비노이드 CB1 수용체에 역효능 또는 길항 활성을 나타내는 신규 1,5-디아릴-4,5-디하이드로-1H-피라졸-3-카복스아미딘 화합물 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 약학 조성물에 관한 것으로, 본 발명에 따른 화합물은 말초 조직 선택성이 우수하고, 카나비노이드 수용체 길항 활성을 나타내므로 비만 또는 비만 관련 대사질환의 예방 또는 치료에 유용하게 사용될 수 있다.

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Номер записи: 10
25-01-2016 дата публикации

NOVEL FUSED PYRIMIDINE DERIVATIVES FOR INHIBITION OF TYROSINE KINASE ACTIVITY

Номер: KR0101587506B1
Автор: 차미영, 강석종, 김미라, 이주연, 전지영, 조명기, 곽은주, 이광옥, 하태희, 서귀현, 김맹섭
Принадлежит: 한미사이언스 주식회사

... 본 발명은 타이로신 카이네이즈 활성 억제 효과를 갖는 신규 융합 피리미딘 유도체에 관한 것으로, 본 발명의 신규 화합물을 활성성분으로 함유하는 약학 조성물은 암, 종양, 염증성 질환, 자가면역 질환 또는 면역학적으로 매개된 질환을 치료하거나 예방하는 효과를 제공한다.

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Номер записи: 11
08-07-2016 дата публикации

NOVEL METHOD FOR MANUFACTURING THIENOPYRIMIDINE COMPOUND AND INTERMEDIATE USED THEREFOR

Номер: KR1020160082479A
Автор: BAEK, JONG OUK, JUNG, JAE HYUK, KIM, HO SEOK, HA, TAE HEE, SUH, KWEE HYUN
Принадлежит:

The present invention relates to a novel method for manufacturing thienopyrimidine derivatives of chemical formula 1, and to a novel intermediate used therefor. The novel method for manufacturing thienopyrimidine derivatives has the activities for selectively inhibiting tyrosine kinase, and particularly mutant epidermal growth factor receptor. The method for manufacturing a compound of the chemical formula 1 comprises the steps of: obtaining a compound of chemical formula 2 or a pharmaceutically acceptable salt thereof; and performing a reaction of the compound of the chemical formula 2 or the pharmaceutically acceptable salt thereof with a compound of chemical formula 8 or a pharmaceutically acceptable salt thereof, and a base. COPYRIGHT KIPO 2016 ...

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Номер записи: 12
09-08-2018 дата публикации

싸이에노피리미딘 화합물의 하이드로클로라이드 염의 결정형

Номер: KR1020180089903A
Автор: 백종욱, 전지영, 오희숙, 김희철, 장선영, 하태희
Принадлежит:

... 본 발명은 N-(3-(2-(4-(4-메틸피페라진-1-일)페닐아미노)싸이에노[3,2-d]피리미딘-4-일옥시)페닐)아크릴아미드의 하이드로클로라이드 염의 결정형 및 이를 포함하는 약학적 조성물에 관한 것이다. 상기 화합물의 하이드로클로라이드 염의 결정형은 이를 유효 성분으로 포함하는 약학적 조성물을 제조하는데 용이하게 사용될 수 있다.

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Номер записи: 13
11-05-2017 дата публикации

NOVEL PROCESS FOR PREPARING THIENOPYRIMIDINE COMPOUND AND INTERMEDIATE USED THEREIN

Номер: KR1020170050453A
Автор: JANG, WOOK, MOON, YOUNG HO, HA, TAE HEE, SUH, KWEE HYUN
Принадлежит:

The present invention relates to a novel process for preparing thienopyrimidine compound which has an activity of selectively controlling tyrosine kinase, especially tyrosine kinase, which is a variable epithelial cell receptor; and a novel intermediate used therein. According to the process of the present invention, a compound which is represented by chemical formula 1, and is useful as a treatment medicine of non-small-cell lung cancer caused by tyrosine kinase, which is a variable epithelial cell receptor, can be industrially mass-produced through a simpler and more effective way compared to existing technologies. COPYRIGHT KIPO 2017 ...

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Номер записи: 14