N,n'-diarylurea compounds and n,n'-diarylthiourea compounds as inhibitors of translation initiation

Compositions and methods for inhibiting translation initiation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using N,N′-diarylureas and/or N,N′-diarylthiourea compounds are described.

QUALITY CONTROL BIOASSAYS FOR NUTRICEUTICAL AND MEDICINAL PRODUCTS

Bioassays for detecting the ability of one sample of a food substance, nutritional supplement, therapeutic agent and/or disease preventive agent relative to that of a second sample of such a substance, supplement and/or agent to inhibit, upregulate or otherwise modulate translation initiation, and thereby demonstrate a disease curative and/or preventive effect in a human and/or animal that consumes a such substance, supplement and/or agent or to whom a such substance, supplement and/or agent is administered are provided. 158-. (canceled)59. A method for identifying or determining whether a substance has one or more beneficial biological , nutriceutical or medicinal properties , the method comprising:expressing in a sample a first biomarker of biomarker of translation initiation inhibition from a first mRNA in the presence of a test substance;detecting a level of expression of the first biomarker in the sample; andcomparing the level of expression of the first biomarker to a level of expression of a control, wherein a level of expression of the first biomarker that is greater than the level of expression of the control indicates that the test substance is a substance that has one or more beneficial biological, nutriceutical or medicinal properties.60. The method of claim 59 , wherein comparing the level of expression of the first biomarker to the level of expression of a control comprises:expressing in a sample a second biomarker of biomarker of translation initiation inhibition from a second mRNA in the presence of a control substance;detecting a level of expression of the second biomarker in the sample; andcomparing the level of expression of the first biomarker to the level of expression of the second biomarker.61. The method of claim 59 , wherein the first mRNA has at least two open reading frames within its 5′ untranslated region and wherein the 5′ untranslated region of the first mRNA is operably linked to a coding region encoding the first biomarker of ...

METHOD AND APPARATUS FOR MANUFACTURE OF COVERED STENTS

The present disclosure is directed to an apparatus () for applying a graft material to a stent. () The apparatus may include a hollow mandrel () adapted to receive a stent. The mandrel () may include apertures adapted to allow a vacuum to be applied in order to temporarily affix the graft material sheath () to the stent. A forming roller () lying axially parallel to and in contact with the stent () may be included. Rotation of the forming roller may rotate the stent about its longitudinal axis. A second roller () for applying the sheath () of graft material to the stent as the stent () is rotated about its axis may be included. Further, the present disclosure is directed to a method of manufacturing stent grafts. 1. An apparatus for applying a graft material to a stent , the apparatus comprising:a mandrel adapted to receive the stent within the apparatus;a forming roller lying axially parallel to and in contact with the stent, whereby rotation of the forming roller rotates the stent about its longitudinal axis;mechanical means for applying a sheath of graft material to the stent as the stent is rotated about its axis; andmechanical means for synchronising the rotation of the stent with the means for applying the graft material, the stent receiving mandrel being a hollow tube provided with small apertures in the region of the receiving area of the stent to allow a vacuum to be applied in order to temporarily affix a graft material sheath to the stent.2. The apparatus according to claim 1 , wherein the means for applying the sheath of graft material to the stent includes a pressure roller lying axially parallel to the stent and arranged to press the sheath of graft material against the stent.3. The apparatus according to wherein the mechanical means for synchronising the rotation of the stent with the means for applying the sheath of graft material to the stent is provided by intermediate gearing means in operative cooperation with the forming roller.4. The apparatus ...

DRIVER CIRCUIT FOR TRANSMITTING COIL OF ACTIVE ANTIMAGNETIC CARD COPYING DEVICE

The present invention relates to a driver unit that locates the transmitter, which transmits magnetic field around the card insertion slot in order to prevent fraud in self-service terminals (SST) such as ATM, which enables transactions with magnetic tape cards. 1. A driver circuit driving a transmitter coil transmitting an electromagnetic field to prevent copying card information of a magnetic card by a copying device located around a card insertion slot of an SST comprising a card insertion slot and a card reader , wherein the driver circuit comprises an H-bridged driver circuit or a symmetric powered driver circuit.2. A driver circuit according to the claim 1 , wherein the H-bridge comprises flyback diodes for eliminating influence of emf that the transmitter coil generates.3. A driver circuit according to the claim 1 , further comprising a capacitor connected serially to the coil on the H-bridge.4. A driver circuit according to the claim 1 , wherein the H-bridge comprises semi-conductor or non-semi conductor switching elements such as transistor claim 1 , mosfet claim 1 , IGBT.5. A driver circuit according to the claim 2 , characterized in that flyback diodes used on the H-bridge comprise semi-conductor or non-semi conductor switching elements such as transistor claim 2 , mosfet claim 2 , IGBT.6. A driver circuit driving a transmitter coil transmitting an electromagnetic field to prevent copying card information of a magnetic card by a copying device located around a card insertion slot of an SST comprising a card insertion slot and a card reader claim 2 , wherein the driver circuit comprises a symmetric powered driver circuit.7. A driver circuit according to the claim 6 , wherein the symmetric powered driver circuit comprises flyback diodes for eliminating the influence of emf that the transmitter coil generates.8. A driver circuit according to the claim 6 , further comprising a capacitor connected serially to the coil.9. A driver circuit according to the claim ...

Self Service Terminal, An Anti-Skimming Unit, A Card Reader Device, A Bezel, A Method of Jamming and Use of an Anti-Skimming Unit

The invention relates to a self service terminal, such as an Automated Teller Machine, comprising a front panel provided with a card insertion slot for inserting a magnetic card therethrough, wherein, during insertion through the insertion slot, a magnetic stripe on the card induces a card data flux into a stripe data reading zone. The terminal also comprises an anti-skimming unit for generating a jamming field so as to jam a magnetic recording unit of an illegal card reader installed near or in the card insertion slot of the front panel. The anti-skimming unit includes a first magnetic field source and at least one further magnetic field source, each source inducing a electro-magnetic field in a slot region including the card insertion slot, such that the jamming field in the stripe date reading zone deviates from the jamming field outside the stripe data reading zone. 1. A self service terminal , such as an Automated Teller Machine , comprising a front panel provided with a card insertion slot for inserting a magnetic card therethrough , wherein , during insertion through the insertion slot , a magnetic stripe on the card induces a card data flux into a stripe data reading zone (D) , the terminal also comprising an anti-skimming unit for generating a jamming field so as to jam a magnetic recording unit of an illegal card reader installed near or in the card insertion slot of the front panel , wherein the anti-skimming unit includes a first magnetic field source and at least one further magnetic field source , each source inducing a electro-magnetic field in a slot region (S) including the card insertion slot , such that the jamming field in the stripe date reading zone (D) deviates from the jamming field outside the stripe data reading zone (D).2. The self service terminal according to claim 1 , wherein the electro-magnetic field induced by the first magnetic field source vanishes in the stripe data reading zone (D) and wherein the at least one further field ...

Discontinuous reception for sidelink

The apparatus of the wireless communication may include a first wireless device configured to transmit sidelink control information (SCI) reserving periodic resources for an initial transmission and aperiodic resources for one or more retransmissions over a sidelink, transmit the initial transmission using the periodic resources, and transmit the one or more retransmissions using the aperiodic resources. The apparatus of wireless communication may also include a second wireless device may be configured to receive the SCI indicating the set of resources for the sidelink transmission from the first wireless device, determine a first resource in the set of resources is periodically reserved, and determine one or more remaining resources in the set of resources is aperiodically reserved.

Network Architecture, Methods, and Devices for a Wireless Communications Network

Methods and apparatus in a fifth-generation wireless communications network, including an example method, in a wireless device, that includes determining a reporting quality threshold for a parameter related to channel state information (CSI); performing a measurement for each of a plurality of beams from a first predetermined set of beams for evaluation; evaluating the measurement for each of the plurality of beams against the reporting quality threshold; discontinuing the performing and evaluating of measurements in response to determining that the reporting quality threshold is met for one of the beams, such that one or more beams in the first predetermined set of beams are not measured and evaluated; and reporting, to the wireless communications network, CSI for the one of the beams. 2. The method of claim 1 , wherein said determining is further based on a desired data rate.3. The method of claim 1 , wherein said determining is further based on a desired minimum bandwidth.4. The method of claim 1 , wherein the method further comprises:receiving a downlink signal comprising an uplink access configuration index;using the uplink access configuration index to identify an uplink access configuration from among a predetermined plurality of uplink access configurations; andtransmitting to the wireless communications network according to the identified uplink access configuration.5. The method of claim 1 , wherein the first numerology has a first subcarrier spacing and the second numerology has a second subcarrier spacing claim 1 , the first subcarrier spacing differing from the second subcarrier spacing.6. The method of claim 1 , wherein the first and second downlink subframes are received on the same carrier frequency.7. The method of claim 1 , wherein subframes of the first and second numerologies comprise first and second predetermined numbers of OFDM symbols claim 1 , respectively.8. The method of claim 1 , wherein at least one of the first and second numerologies ...

SUBSTITUTED QUINAZOLINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR4

The present invention relates to novel quinazolinone derivatives of formula (I) as well as pharmaceutical compositions containing these compounds. The compounds of formula (I) as provided herein can act as positive allosteric modulators of metabotropic glutamate receptor subtype 4 (mGluR4), and can thus be used as therapeutic agents, particularly in the treatment or prevention of conditions associated with altered glutamatergic signalling and/or functions or conditions which can be affected by alteration of glutamate level or signalling. 3. The compound of claim 1 , wherein each Rand each Ris independently selected from Calkyl claim 1 , —(Calkylene)-OH claim 1 , —(Calkylene)-O(Calkyl) claim 1 , —(Calkylene)-SH claim 1 , —(Calkylene)-S(Calkyl) claim 1 , —(Calkylene)-NH claim 1 , —(Calkylene)-NH(Calkyl) claim 1 , —(Calkylene)-N(Calkyl)(Calkyl) claim 1 , —(Calkylene)-halogen claim 1 , —(Calkylene)-(Chaloalkyl) claim 1 , —(Calkylene)-O—(Chaloalkyl) claim 1 , —(Calkylene)-CN claim 1 , —(Calkylene)-CHO claim 1 , —(Calkylene)-CO—(Calkyl) claim 1 , —(Calkylene)-COOH claim 1 , —(Calkylene)-CO—O—(Calkyl) claim 1 , —(Calkylene)-O—CO—(Calkyl) claim 1 , —(Calkylene)-CO—NH claim 1 , —(Calkylene)-CO—NH(Calkyl) claim 1 , —(Calkylene)-CO—N(Calkyl)(Calkyl) claim 1 , —(Calkylene)-NH—CO—(Calkyl) claim 1 , —(Calkylene)-N(Calkyl)-CO—(Calkyl) claim 1 , —(Calkylene)-SO—NH claim 1 , —(Calkylene)-SO—NH(Calkyl) claim 1 , —(Calkylene)-SO—N(Calkyl)(Calkyl) claim 1 , —(Calkylene)-NH—SO—(Calkyl) claim 1 , and —(Calkylene)-N(Calkyl)-SO—(Calkyl).4. The compound of claim 1 , wherein Xis C(-L-R).5. The compound of claim 1 , wherein Xis C(R) claim 1 , Xis C(-L-R) claim 1 , Xis C(R) claim 1 , and Xis C(R).6. The compound of claim 1 , wherein Ris selected from cycloalkyl claim 1 , aryl claim 1 , heterocycloalkyl claim 1 , and heteroaryl claim 1 , wherein said cycloalkyl claim 1 , said aryl claim 1 , said heterocycloalkyl claim 1 , and said heteroaryl are each optionally substituted with one or more ...

Apparatus for Prevention of Reading of Magnetic Cards

A card reading machine includes a card reader for reading data on a magnetic card and a device for preventing reading of the data on the magnetic card by illegal card reading devices operatively associated with the card reading machine. The device for preventing may include an oscillator, a driver circuit and a coil for generating electromagnetic signals similar to data on a card. A method for preventing reading of data on a magnetic card by in illegal card reader in operative association with an apparatus having a card reader intended to read the data on the magnetic card includes producing a signal ruining the data collected by the illegal card reader. The apparatus having a card reader may include an insertion slot in which case the method may further include producing the signal near the insertion slot. 1. A card reading machine comprising:a card reader for reading data on a magnetic card by receiving data signals generated in the card reader as the magnetic card is passed along the card reader, the data signals being at a select frequency range; anda device for preventing reading of the data on the magnetic card by an illegal card reading device operatively associated with the card reading machine, the illegal card reading device reading data on the magnetic card by receiving signals generated in the illegal card reading device as the magnetic card is passed along the illegal card reading device, the signals being at the same select frequency range as the data signals,wherein the device for preventing reading comprises an oscillator, a driver circuit and a coil for generating preventing signals at the select frequency range when the magnetic card is passed along the illegal card reading device, the preventing signals being so similar in frequency range to signals generated in the illegal card reading device as the magnetic card is passed along the illegal card reading device, that the preventing signals and signals generated in the illegal card reading device ...

DMF DISTILLATION

A method of obtaining purified DMF from a mixture comprising DMF and hydrogen chloride (HCl) involving distillation is provided. 1. A method of producing purified dimethylformamide from a feed mixture comprising dimethylformamide and hydrogen chloride , comprising:distilling the feed mixture to afford a more volatile fraction and a less volatile fraction, wherein the more volatile fraction is lower in hydrogen chloride, measured as chloride, than the less volatile fraction, andcollecting the more volatile fraction to afford a collected more volatile fraction, at least a portion of which affords a purified dimethylformamide product that is lower in hydrogen chloride, measured as chloride, than the feed mixture;wherein the hydrogen chloride content of the feed mixture, measured as chloride, is from 0.1% to 10% (w/w) and the hydrogen chloride content of the purified dimethylformamide, measured as chloride, is from 0 to 1000 ppm.2. The method according to wherein the hydrogen chloride content claim 1 , measured as chloride (w/w) claim 1 , of the purified dimethylformamide is less than 50% of the is hydrogen chloride content claim 1 , measured as chloride (w/w) claim 1 , of the feed mixture.3. The method according to wherein the hydrogen chloride content claim 1 , measured as chloride (w/w) claim 1 , of the purified dimethylformamide is less than 25% of the hydrogen chloride content claim 1 , measured as chloride (w/w) claim 1 , of the feed mixture.4. The method according to wherein the hydrogen chloride content claim 1 , measured as chloride (w/w) claim 1 , of the purified dimethylformamide is less than 10% of the hydrogen chloride content claim 1 , measured as chloride (w/w) claim 1 , of the feed mixture.5. The method according to claim 1 , wherein the distillation of the feed mixture is carried out in a distillation column.6. The method according to claim 5 , wherein the distillation column comprises an upper rectifying section and a lower stripping section.7. The ...

Network Architecture, Methods, and Devices for a Wireless Communications Network

Methods and apparatus in a fifth-generation wireless communications, including an example method, in a wireless device, that includes receiving a downlink signal comprising an uplink access configuration index, using the uplink access configuration index to identify an uplink access configuration from among a predetermined plurality of uplink access configurations, and transmitting to the wireless communications network according to the identified uplink access configuration. The example method further includes, in the same wireless device, receiving, in a first subframe, a first Orthogonal Frequency-Division Multiplexing (OFDM) transmission formatted according to a first numerology and receiving, in a second subframe, a second OFDM transmission formatted according to a second numerology, the second numerology differing from the first numerology. Variants of this method, corresponding apparatuses, and corresponding network-side methods and apparatuses are also disclosed.

Network Architecture, Methods, and Devices for a Wireless Communications Network

Methods and apparatus in a fifth-generation wireless communications, including an example method, in a wireless device, that includes receiving a downlink signal comprising an uplink access configuration index, using the uplink access configuration index to identify an uplink access configuration from among a predetermined plurality of uplink access configurations, and transmitting to the wireless communications network according to the identified uplink access configuration. The example method further includes, in the same wireless device, receiving, in a first subframe, a first Orthogonal Frequency-Division Multiplexing (OFDM) transmission formatted according to a first numerology and receiving, in a second subframe, a second OFDM transmission formatted according to a second numerology, the second numerology differing from the first numerology. Variants of this method, corresponding apparatuses, and corresponding network-side methods and apparatuses are also disclosed. 1. A wireless communications network , the wireless communications network comprising: processing circuitry configured to process received first user data and provide second user data, and', radio-frequency circuitry, and', receive information indicating a plurality of uplink access configurations, each uplink access configuration including a random access configuration;', 'receive an uplink access configuration index, using the uplink access configuration index to identify an uplink access configuration from among the indicated plurality of uplink access configurations, and transmit a message to the wireless communications network according to the identified uplink access configuration; and', 'subsequently transmit the first user data; and', 'receive in response to the transmitted message a first Orthogonal Frequency-Division Multiplexing (OFDM) transmission formatted according to a first numerology and receive a second OFDM transmission formatted according to a second numerology and carrying the ...

POSITIONING DEVICE FOR LOCATION POSITIONING OF ENERGY STORAGE CELLS

A positioning device for location positioning of a plurality of energy storage cells of an energy storage device of a vehicle, a cover for closing such a positioning device, an energy storage device with such a positioning device, and a such cover are provided. The present disclosure is based on a general idea of providing a positioning device for energy storage cells which allows both material savings and functional integration of a number of functions. 1. A positioning device for location positioning a plurality of energy storage cells in an energy storage device of a vehicle , the positioning device comprising:a base which forms a plurality of positioning recesses into which the energy storage cells can be inserted for location positioning; anda frame which is arranged on the base and is formed peripherally around the positioning recesses;wherein the base and the frame are designed in such a way that together they form an accommodating space for accommodating the plurality of energy storage cells and for accommodating a casting compound,wherein the accommodating space has an accommodating volume, andwherein the frame is designed to be adapted at least in sections to the body shape of an energy storage cell in order to reduce the accommodating volume.2. The positioning device of claim 1 , wherein:{'b': '2', 'the positioning device for location positioning of energy storage cells () is designed with a cylindrical body shape, and/or'}the base forms a plurality of positioning recesses into which energy storage cells with a circular-cylindrical body shape can be inserted for location positioning.3. The positioning device of claim 1 , wherein the frame is designed to reduce the accommodating volume claim 1 , at least in sections claim 1 , to complement the body shape of an energy storage cell and/or a plurality of energy storage cells.4. The positioning device of claim 1 , wherein:the frame forms a plurality of circular cylinder segments,the circular cylinder segments ...

SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ALLOSTERIC MODULATORS OF GROUP II METABOTROPIC GLUTAMATE RECEPTORS

The present invention provides novel heterocyclic compounds of the general formula (I), including novel compounds of formula (Ia), and pharmaceutical compositions containing them. Moreover, the compounds of formula (I) or (Ia) and the pharmaceutical compositions containing them are provided for use in the treatment and/or prophylaxis of conditions associated with altered glutamatergic signalling and/or functions, and/or conditions which can be affected by alteration of glutamate level or signalling in mammals. The compounds of formula (I) or (Ia) can act as modulators of nervous system receptors sensitive to glutamate, in particular as modulators of metabotropic glutamate receptors (mGluRs), which makes them particularly suitable for the treatment and/or prophylaxis of acute and chronic neurological and/or psychiatric disorders. The present invention further provides compounds of formula (I) or (Ia) that are modulators of metabotropic glutamate receptors (mGluRs), particularly positive allosteric modulators of mGluRs, and more specifically positive allosteric modulators of mGluR3. 2. A compound of formula (Ia) as defined in or a pharmaceutically acceptable salt claim 1 , solvate or prodrug thereof claim 1 , for use in the treatment and/or prophylaxis of Parkinson's disease.3. A compound of formula (Ia) as defined in or a pharmaceutically acceptable salt claim 1 , solvate or prodrug thereof; wherein Rand Rare mutually linked to form claim 1 , together with the carbon atom that they are attached to claim 1 , a cycloalkyl or a heterocycloalkyl.4. The compound of for use as a medicament.5. A compound of formula (Ia) as defined in or a pharmaceutically acceptable salt claim 1 , solvate or prodrug thereof; wherein A is heteroaryl claim 1 , said heteroaryl being different from pyrimidinyl and from 1 claim 1 ,3-benzodioxolyl; for use as a medicament.7. A compound of formula (Ia) as defined in or a pharmaceutically acceptable salt claim 1 , solvate or prodrug thereof; ...

HOUSING FOR AN ENERGY STORAGE DEVICE OF A VEHICLE

A housing for an energy storage device of a vehicle may include a main housing and a temperature control plate. The main housing may form a housing interior for a plurality of energy storage cells of the energy storage device. A temperature control fluid may flow through the temperature control plate for the temperature control of the plurality of energy storage cells. The main housing and the temperature control plate may be configured such that the temperature control plate can be inserted into the housing interior in an insertion direction. In an inserted configuration, the temperature control plate may form a positive connection with the main housing which may prevent displacement of the temperature control plate in the main housing transversely to the insertion direction. 1. A housing for an energy storage device of a vehicle , comprising:a main housing forming a housing interior for a plurality of energy storage cells of the energy storage device; anda temperature control plate through which a temperature control fluid can flow for the temperature control of the plurality of energy storage cells;wherein the main housing and the temperature control plate are configured such that the temperature control plate can be inserted into the housing interior in an insertion direction, and in an inserted configuration, the temperature control plate forms a positive connection with the main housing which prevents displacement of the temperature control plate in the main housing transversely to the insertion direction.2. The housing according to claim 1 , wherein:the temperature control plate forms a connection side and a deflection side spaced from the connection side;the temperature control plate forms at least one fluid channel arrangement that has a forward channel and a return channel for guiding the temperature control fluid through the temperature control plate;the forward channel and the return channel are spaced apart from one another and each pass completely ...

CHLORINATION OF SUCROSE-6-ESTERS

There is provided a method for the chlorination of a sucrose-6-acylate to produce a 4,1′,6′-trichloro-4,1′,6′-trideoxy-galactosucrose-6-acylate, wherein said method comprises the following steps (i) to (v): (i) providing a first component comprising sucrose-6-acylate; (ii) providing a second component comprising a chlorinating agent; (iii) combining said first component and said second component to afford a mixture; (iv) heating said mixture for a heating period in order to provide chlorination of sucrose-6-acylate at the 4, 1′ and 6′ positions thereof; (v) quenching said mixture to produce a 4,1′,6′-trichloro-4,1′,6′-trideoxy-galactosucrose-6-acylate; wherein at least one of said first component and said second component comprises a reaction vehicle, and said reaction vehicle comprises a tertiary amide; and wherein said mixture comprises a cosolvent during a least a portion of the heating period of step (iv), wherein said cosolvent comprises perfluorooctane. 1. A method for the chlorination of a sucrose-6-acylate to produce a 4 ,1′ ,6′-trichloro-4 ,1′ ,6′-trideoxy-galactosucrose-6-acylate , wherein said method comprises the following steps (i) to (v):(i) providing a first component comprising sucrose-6-acylate;(ii) providing a second component comprising a chlorinating agent;(iii) combining said first component and said second component to afford a mixture;(iv) heating said mixture for a heating period in order to provide chlorination of sucrose-6-acylate at the 4, 1′ and 6′ positions thereof;(v) quenching said mixture to produce a 4,1′,6′-trichloro-4,1′,6′-trideoxy-galactosucrose-6-acylate;wherein at least one of said first component and said second component comprises a reaction vehicle, and said reaction vehicle comprises a tertiary amide; andwherein said mixture comprises a cosolvent during a least a portion of the heating period of step (iv), wherein said cosolvent comprises perfluorooctane.2. A method according to claim 1 , wherein both of said first ...

Quality Control Bioassays For Nutriceutical And Medicinal Products

Bioassays for detecting the ability of one sample of a food substance, nutritional supplement, therapeutic agent and/or disease preventive agent relative to that of a second sample of such a substance, supplement and/or agent to inhibit, upregulate or otherwise modulate translation initiation, and thereby demonstrate a disease curative and/or preventive effect in a human and/or animal that consumes a such substance, supplement and/or agent or to whom a such substance, supplement and/or agent is administered are provided. 1. A method for identifying or determining whether a substance has one or more beneficial biological , nutriceutical or medicinal properties comprising the steps of:providing a first sample including a first mRNA sequence having at least two open reading frames at its 5′ untranslated region (UTR), wherein the first mRNA sequence encodes a first biomarker protein;providing a second sample including a second mRNA sequence having at least two open reading frames at its 5′ UTR, wherein the second mRNA sequence encodes a second biomarker protein;contacting the second sample with the substance; anddetecting translation levels of the first and second biomarker proteins, wherein the translation level of the second biomarker protein is greater than the translation level of the first biomarker if the substance has one or more beneficial biological, nutriceutical or medicinal properties.2. The method of claim 1 , wherein the first sample is contacted with a standard substance or a control substance.3. The method of claim 1 , wherein the first mRNA and the second mRNA have the same sequence.4. The method of claim 1 , wherein the first biomarker protein and the second biomarker protein are the same protein.5. The method of claim 1 , wherein the first and second biomarker proteins are selected from the group consisting of breast cancer 1 (BRCA1) transcript b product claim 1 , activating transcription factor 4 (ATF-4) claim 1 , translationally controlled tumor ...

Multi-Factor Authentication

A method is disclosed in which one or more pieces of first authentication information are obtained. The one or more pieces of first authentication information represent at least one piece of unique information associated with a user and/or an electronic device of the user. A trust level is determined based, at least in part, on the one or more pieces of first authentication information. The trust level value is indicative of a level of trust in the one or more pieces of first authentication information. An according apparatus, computer program, and system are also disclosed.

Method for Producing a Composition Containing at Least one Metal Amino Acid Compound and Composition Obtainable by Means of a Method of this Kind

The invention relates to a method for producing a composition containing at least one metal amino acid compound, in which method —a basic compound of a divalent metal is first reacted together with an alpha amino acid in a molar relationship of one to at least two in water during heating of up to 60° C. to 100° C., —a reaction equilibrium is awaited, —the reaction solution is then mixed with a water-soluble salt of the same divalent metal at a quantity such that the molar total quantity of the divalent metal from the basic compound of the metal and the metal salt does not exceed the molar quantity of the alpha amino acid, —the metal salt is allowed to completely dissolve, —the reaction solution is then dried thereby obtaining a solid composition. 114.-. (canceled)15. A method for preparing a composition comprising at least one metal-amino acid compound , the method comprising:carrying out a reaction of a basic compound of a divalent metal with an alpha-amino acid in a molar ratio of 1 to at least 2 in water while heating to 60° C. to 100° C.;waiting until the reaction has reached an equilibrium;adding to a reaction solution of the reaction a water-soluble metal salt of the divalent metal in an amount such that a molar total amount of the divalent metal of the basic compound of the divalent metal and of the metal salt of the divalent metal does not exceed a molar amount of the alpha-amino acid;waiting until the water-soluble metal salt of the divalent metal has completely dissolved;drying the reaction solution to obtain the composition as a solid.16. The method according to claim 15 , further comprising the step of selecting the basic compound of the divalent metal from the group consisting of a hydroxide claim 15 , a carbonate claim 15 , a hydroxide carbonate claim 15 , and an oxide.17. The method according to claim 15 , further comprising the step of selecting the divalent metal from the group consisting of copper claim 15 , manganese claim 15 , zinc claim 15 , and ...

DATA STREAMS WITH DIFFERENT PRIORITIES IN CONTENTION-BASED SYSTEMS

A method by a communication device accesses a shared communication channel using a contention based access protocol. The communication device is configured to transmit data streams with different transmission priorities via the shared communication channel with a first data stream having a higher transmission priority than a second data stream. A method includes observing whether the shared communication channel is available for transmission, where when the shared communication channel is available for transmission, and the communication device waits for the duration of a time interval randomly selected from a time range in which the shared communication channel is available for transmission before the transmission is started. A first time interval is selected from a first time range for the transmission of the first data stream, and a second time interval is selected from a second time range for the transmission of the second data stream wherein the second time range does not overlap with the first time range. 1. A method for accessing , by a communication device , a shared communication channel in which contention based access to the communication channel is used , the communication device being configured to transmit data streams with different transmission priorities via the shared communication channel with a first data stream having a higher transmission priority than a second data stream , comprising:observing whether the shared communication channel is available for transmission, wherein when the shared communication channel is available for transmission, andthe communication device waits for the duration of a time interval randomly selected from a time range in which the shared communication channel is available for transmission before the transmission is started, wherein a first time interval is selected from a first time range for the transmission of the first data stream, and a second time interval is selected from a second time range for the ...

CONTROL USING NR TDD

A wireless device, network node and methods using new radio time division duplex, NR-TDD, are provided. In one embodiment, the network node includes processing circuitry configured to configure placement of downlink control messages over at least two symbols of a NR TDD slot. The at least two symbols are different symbols in the time domain. 1. A network node using new radio time division duplex , NR TDD , the network node comprising: 'configure positioning of at least two control messages over at least two symbols of a NR TDD slot, the at least two symbols being different symbols in a time domain.', 'processing circuitry configured to2. The network node of claim 1 , wherein each control message corresponds to a respective symbol of the at least two symbols of the NR TDD slot.3. The network node of claim 1 , wherein the at least two control messages include:a downlink Hybrid Automatic Repeat Request, HARQ, configured to be positioned on a first symbol of the at least two symbols of the NR TDD slot; anda scheduling request configured to be positioned on a second symbol of the at least two symbols of the NR TDD slot, the first symbol being positioned, in the time domain, before the second symbol.4. (canceled)5. The network node of claim 1 , wherein a second control message corresponds to the last symbol of the symbols used for uplink and/or corresponds to the last symbol of the NR TDD slot.6. (canceled)7. The network node of claim 1 , wherein the at least two control messages include:a downlink assignment configured to be positioned on a first symbol of the at least two symbols of the NR TDD slot; andan uplink assignment or uplink Hybrid Automatic Repeat Request, HARQ, configured to be positioned on a second symbol of the at least two symbols of the NR TDD slot, the first symbol being positioned, in the time domain, before the second symbol.8. (canceled)9. The network node of claim 1 , wherein a first control message corresponds to a first symbol of the symbols used ...

CHLORINATION OF SUCROSE-6-ESTERS

There is provided a method for the chlorination of a sucrose-6-acylate to produce a 4,1′,6′-trichloro-4,1′,6′-trideoxy-galactosucrose-6-acylate, wherein said method comprises the following steps (i) to (v): (i) providing a first component comprising sucrose-6-acylate; (ii) providing a second component comprising a chlorinating agent; (iii) combining said first component and said second component to afford a mixture; (iv) heating said mixture for a heating period in order to provide chlorination of sucrose-6-acylate at the 4, 1′ and 6′ positions thereof; (v) quenching said mixture to produce a 4,1′,6′-trichloro-4,1′,6′-trideoxy-galactosucrose-6-acylate; wherein at least one of said first component and said second component comprises a reaction vehicle, and said reaction vehicle comprises a tertiary amide; and wherein said mixture comprises a cosolvent during a least a portion of the heating period of step (iv), wherein said cosolvent comprises dimethylacetamide (DMAc). 1. A method for the chlorination of a sucrose-6-acylate to produce a 4 ,1′ ,6′-trichloro-4 ,1′ ,6′-trideoxy-galactosucrose-6-acylate , wherein said method comprises the following steps (i) to (v):(i) providing a first component comprising sucrose-6-acylate;(ii) providing a second component comprising a chlorinating agent;(iii) combining said first component and said second component to afford a mixture;(iv) heating said mixture for a heating period in order to provide chlorination of sucrose-6-acylate at the 4, 1′ and 6′ positions thereof;(v) quenching said mixture to produce a 4,1′,6′-trichloro-4,1′,6′-trideoxy-galactosucrose-6-acylate;wherein at least one of said first component and said second component comprises a reaction vehicle, and said reaction vehicle consists of dimethylformamide (DMF); andwherein said mixture comprises a cosolvent during a least a portion of the heating period of step (iv), wherein said cosolvent comprises dimethylacetamide (DMAc).2. A method according to claim 1 , wherein ...

DMF DISTILLATION

A method of obtaining purified DMF from a mixture comprising DMF and hydrogen chloride (HCl) involving distillation is provided. 1. A method of producing purified dimethylformamide from a feed mixture comprising dimethylformamide and hydrogen chloride , comprising:distilling the feed mixture to afford a more volatile fraction and a less volatile fraction, wherein the more volatile fraction has a lower hydrogen chloride content than the less volatile fraction, andcollecting the more volatile fraction to afford a collected more volatile fraction, at least a portion of which affords a purified dimethylformamide product that is lower in hydrogen chloride content than the feed mixture.2. A method according to claim 1 , wherein the distillation is carried out in a distillation column.3. A method according to claim 2 , wherein the distillation column comprises an upper rectifying section and a lower stripping section.4. A method according to claim 3 , wherein the feed mixture is introduced to the distillation column between the rectifying and stripping sections thereof.5. A method according to claim 1 , wherein a portion of the collected more volatile fraction is returned to the distillation column as a reflux stream.6. A method according to claim 5 , wherein the reflux stream is introduced to the distillation column at a point above the point at which the feed mixture is introduced to the distillation column.7. A method according to claim 5 , wherein the reflux stream is introduced to the distillation column at the top of the rectifying section.8. A method according to claim 5 , wherein the ratio of the amount of the collected more volatile fraction returned as a reflux stream to the amount of the collected more volatile fraction taken forward as purified dimethylformamide product is from 0.1:1 to 4:1 (w/w).9. A method according to claim 8 , wherein the ratio of the amount of the collected more volatile fraction returned as a reflux stream to the amount of the collected ...

ELECTRIC BATTERY

An electric battery for, e.g., a motor vehicle, is disclosed. The electric battery includes a base, at least two battery cell modules arranged on the base at a cell spacing to one another, and at least two housing parts secured to the base and each defining, together with the base, a respective interior housing space. The interior housing spaces accommodate at least one of the battery cell modules. The at least two battery cell modules arranged in the interior space adjacent to one another are electrically connected to one another via an electrical connecting line passing through an intermediate space between the at least two battery cell modules. 1. An electric battery , comprising:a base including a baseplate,at least two battery cell modules that are arranged on the base at a cell spacing from one another, such that an intermediate space is provided between the at least two battery cell modules,at least two housing parts that are secured on the base, each of the at least two housing parts together with the base defining a respective interior housing space,each of the interior housing spaces accommodating at least one of the at least two battery cell modules, andthe at least two battery cell modules arranged in the interior housing spaces adjacent to one another being electrically connected to one another via an electrical connecting line passing through the intermediate space.2. The electric battery according to claim 1 , wherein the base further includes a carrier that is arranged in the intermediate space between the at least two battery cell modules on the baseplate of the base.3. The electric battery according to claim 2 , further comprising a feed-through arranged in the carrier claim 2 , wherein the electrical connecting line passes through the feed-through to provide the electrical connection of the at least two battery cell modules.4. The electric battery according to claim 3 , wherein:the feed-through accommodates a feed-through profile that delimits an ...

Allocating Radio Resources for One or More Radio Devices in a Industrial Application

Method of allocating radio resources for one or more radio devices (A, B, C, D, DX) in an industrial application (IA), the method comprising: allocating radio resources to at least one non-stationary radio device (A, B, C, D, DX) such that radio resources allocated to the non-stationary device (A, B, C, D, DX) in a first cell (S) are exclusively available for the non-stationary device (A, B, C, D, DX) in at least one second cell (T) next to, preferably adjacent to, the first cell (S). 119-. (canceled)20. A method of allocating radio resources for one or more radio devices in an industrial application (IA) , the method comprising:allocating radio resources to at least one non-stationary radio device such that radio resources allocated to the non-stationary device in a first cell are exclusively available for the non-stationary device in at least one second cell next to the first cell.21. The method of claim 20 , further comprising allocating radio resources to at least one stationary radio device such that claim 20 , for at least one stationary radio device in the first cell claim 20 , the radio resources are available to another stationary radio device in the at least one second cell next to the first cell.22. The method of claim 20 , further comprising:allocating radio resources to at least one other non-stationary radio device in a third cell, wherein the radio resources allocated to the other non-stationary device in the third cell correspond to the radio resources allocated to the non-stationary device in the first cell;wherein the third cell is a non-neighboring cell to the first cell.23. The method of claim 20 , further comprising allocating radio resources such that radio resources allocated to a first traffic type in the first cell are exclusively available for the first traffic type in at least one second cell next to the first cell.24. The method of claim 20 , further comprising allocating radio resources such that radio resources allocated to a second ...

SILICONE BASED EXPANDABLE TIRE CURING BLADDER

A Silicon based expandable curing bladder comprising, an expandable tire curing bladder () composition comprising a silicone base at least 50 to 99 percent by weight of the composition. The curing bladder () comprising a silicon base and/or additives which are selected from the groups consisting of silicon base rubber, silicon base compound, silicone color, platinum catalyst, inhibitor, activator, heat stabilizers, crosslinkers and filler in order to increase release properties of an expandable curing bladder with long durability. A production method which is preferably compression and/or transfer molding or injection molding is also described accordingly. 1. An expandable tire curing bladder , wherein a composition of the expandable tire curing bladder comprises a silicone base , a weight percentage of the silicone base is at least 50 to 99 percent.2. The expandable tire curing bladder according to claim 1 , wherein the weight percentage of the silicon base is ranging from 90 to 95 percent.3. The expandable tire curing bladder according to claim 1 , wherein the silicon base is selected from the group consisting of solid silicone rubber claim 1 , liquid silicone rubber claim 1 , 2-part silicone rubber claim 1 , silicone rubber claim 1 , silicone gel and a mixture of solid silicone rubber claim 1 , liquid silicone rubber claim 1 , 2-part silicone rubber claim 1 , silicone rubber claim 1 , silicone gel.4. The expandable tire curing bladder according to claim 1 , wherein a compound or compounds of the expandable tire curing bladder comprises the silicon base and/or additives claim 1 , the additives are selected from the group consisting of silicon base rubber claim 1 , silicon base compound claim 1 , silicone color claim 1 , platinum catalyst claim 1 , inhibitor claim 1 , activator claim 1 , heat stabilizers claim 1 , crosslinkers and filler.5. The expandable tire curing bladder according to claim 1 , wherein the composition further comprises at least one of additive ...

CELL BASED QUALITY CONTROL BIOASSAYS FOR NUTRICEUTICAL AND MEDICINAL PRODUCTS

A method for determining the translation initiation inhibitory potency of a composition having an unknown level of translation initiation inhibitory activity which comprises contacting an eI-F2α-WT cell with said composition for a time and at a temperature effective to inhibit proliferation of said cell, measuring the level of inhibition of proliferation of said eIF2α-WT cells induced by said sample and comparing the level of inhibition of proliferation induced by said sample with the level of inhibition of proliferation induced by a standard having a known amount of said activity, the amount of said translation initiation inhibitory activity in said sample being proportional to the level of inhibition of proliferation of said eIF2α-WT cell. 1. A method for determining the translation initiation inhibitory potency of a composition having an unknown level of translation initiation inhibitory activity which comprises:contacting an ATCC accession No. PTA-13010 cell with said composition for a time and at a temperature effective to inhibit proliferation of said cell,contacting an ATCC accession No. PTA-13011 cell with said composition for a time and at a temperature effective to inhibit proliferation of said cell,measuring the level of inhibition of proliferation of said ATCC accession No. PTA-13010 cell and said ATCC accession No. PTA-13011 cell induced by said composition,wherein the amount of said translation initiation inhibitory activity in said composition is proportional to the level of inhibition of proliferation of ATCC accession No. PTA-13010 cell, andcomparing the level of inhibition of proliferation induced by said composition with the level of inhibition of proliferation induced by a standard having a known amount of said activity, and,identifying the composition as not having translation initiation inhibitory activity if said composition inhibits the proliferation of said ATCC accession No. PTA-13011 cell.2. The method of wherein said composition is a ...

Access Channel Management for Wireless Communication Devices

A method of managing access to a wireless communication network (), comprising: a wireless communication device () selecting (S) an access channel out of a plurality of access channels (CH, CH, CH) for transmission of a data packet based on a traffic type out of a plurality of traffic types (T, T, T) assigned to the data packet. 145.-. (canceled)46. A method performed by a wireless communication device for managing access to a wireless communication network , comprising:assigning a traffic type, out of a plurality of traffic types, to a data packet to be transmitted;selecting an access channel out of a plurality of access channels for transmission of a data packet based on the traffic type assigned to the data packet; andtransmitting the data packet via the access channel selected.47. The method according to claim 46 , said plurality of traffic types comprising a first claim 46 , a second claim 46 , and a third traffic type claim 46 , wherein:said first traffic type is dedicated to data packets to be transmitted periodically and/or in real-time,said second traffic type is dedicated to data packets to be transmitted according to non-real-time conditions,said third traffic type is dedicated to data packets to be transmitted event-related and/or in real-time.48. The method according to claim 47 , wherein selecting the access channel comprises:selecting a first access channel from said plurality of access channels for a data packet of the first traffic type, said first access channel comprises a first area of time and/or frequency resources;selecting a second access channel from the plurality of access channels for the data packet of the second traffic type, said second access channel comprising a second area of time and/or frequency resources; andselecting a third access channel from the plurality of access channels for a data packet of the third traffic type, said third access channel comprising a third area of time and/or frequency resources.49. The method according ...

Radio Communication of Critical Packet Data Units

A technique for communicating protocol data units, PDUs, in a radio communication from a transmitter () to a receiver () is described. As to a method aspect of the technique, one or more control messages indicative of Quality of Service, QoS, requirements for the radio communication are received. The QoS requirements include a control command for a reliability of the radio communication and a control command for a latency of the radio communication. A batch of redundant PDUs is transmitted from the transmitter () to the receiver (). A number of the redundant PDUs per batch depends on the control command for the reliability and a temporal spread of the redundant PDUs per batch depends on the control command for the latency.

A POWER GENERATOR AND A METHOD OF GENERATING POWER

The invention relates to a power generator. The power generator comprises a vessel provided with a heat exchanging unit for alternatingly heating and cooling an organic based working fluid contained in the interior of the vessel during operation of the power generator. Further, the power generator comprises a mechanical unit associated with the vessel and provided with a reciprocating moving element that moves responsive to the heating and cooling process. The heat exchanging unit is arranged for heating the working fluid from below an evaporation temperature and for cooling the working fluid from above the evaporation temperature. Further, the power generator comprises a pressure transferring structure for transferring a pressure exerted by gas in the vessel towards the mechanical unit for driving the reciprocating moving element. 1. A power generator , comprising a vessel provided with a heat exchanging unit for alternatingly heating and cooling an organic based working fluid contained in the interior of the vessel during operation of the power generator , further comprising a mechanical unit associated with the vessel and provided with a reciprocating moving element that moves responsive to the heating and cooling process , wherein the heat exchanging unit is arranged for heating the working fluid from below an evaporation temperature and for cooling the working fluid from above the evaporation temperature , the power generator further comprising a pressure transferring structure for transferring a pressure exerted by gas in the vessel towards the mechanical unit for driving the reciprocating moving element.2. A power generator according to claim 1 , wherein the pressure transferring structure includes a barring element barring gas to flow towards the mechanical unit.3. A power generator according to claim 2 , wherein the barring element is a flexible membrane sealing an opening in a top part of the vessel.4. A power generator according to claim 2 , wherein the ...

SEPARATION DEVICE FOR AN AEROSOL STREAM

A separation device for separating contaminates from a gas flow may include a raw chamber receiving a contaminated gas and a clean chamber out of which a treated gas exits. A dividing wall may separate the raw chamber from the clean chamber. The dividing wall may include a perforated region defining a plurality of passage openings. The gas flow may be communicated from the raw chamber to the clean chamber via the plurality of passage openings. A gas-permeable separation structure may be arranged on a wall outlet side of the dividing wall facing the clean chamber. The separation structure may separate contaminates from the gas flow when subjected to a through flow. 1. A separation device for separating contaminates from a gas flow , comprising:a raw chamber receiving a contaminated gas,a clean chamber, out of which a treated gas exits,a dividing wall separating the raw chamber from the clean chamber,the dividing wall including a perforated region defining a plurality of passage openings, through which the gas flow communicates from the raw chamber into the clean chamber, 'wherein the separation structure is secured to the dividing wall, the dividing wall including at least one welding rib to which the separation structure is welded.', 'a gas-permeable separation structure arranged on a wall outlet side of the dividing wall facing the clean chamber, wherein the separation structure separates contaminates from the gas flow when subjected to a through-flow, and'}2. The device according to claim 1 , wherein the separation structure is exclusively secured to the dividing wall and isolated from a further component.3. The device according to claim 1 , wherein the separation structure is arranged free-standing in the clean chamber via the at least one welding rib.4. The device according to claim 1 , wherein a structure outlet side of the separation structure facing away from the dividing wall is arranged free-standing in the clean chamber.5. The device according to claim 1 , ...

Network Architecture, Methods, and Devices for a Wireless Communications Network

Methods and apparatus in a fifth-generation wireless communications, including an example method, in a wireless device, that includes receiving a downlink signal comprising an uplink access configuration index, using the uplink access configuration index to identify an uplink access configuration from among a predetermined plurality of uplink access configurations, and transmitting to the wireless communications network according to the identified uplink access configuration. The example method further includes, in the same wireless device, receiving, in a first subframe, a first Orthogonal Frequency-Division Multiplexing (OFDM) transmission formatted according to a first numerology and receiving, in a second subframe, a second OFDM transmission formatted according to a second numerology, the second numerology differing from the first numerology. Variants of this method, corresponding apparatuses, and corresponding network-side methods and apparatuses are also disclosed. 1181-. (canceled)183. The method of claim 182 , further comprising operating in a connected mode for one or more first intervals and operating in a dormant mode for one or more second intervals claim 182 , wherein said first and second OFDM transmissions are performed in the connected mode claim 182 , and wherein said operating in the dormant mode comprises:monitoring signals carrying tracking area identifiers;comparing tracking area identifiers received during said monitoring with a tracking area identifier list; andnotifying the wireless communication network in response to determining that a received tracking area identifier is not on said list but otherwise refraining from notifying the wireless communication network in response to receiving changing tracking area identifiers.184. The method of claim 182 , wherein said first and second downlink subframes are received on the same carrier frequency.185. The method of claim 182 , wherein said first OFDM transmission has a numerology according to ...

Network Architecture, Methods, and Devices for a Wireless Communications Network

Methods and apparatus in a fifth-generation wireless communications network, including an example method, in a wireless device, that includes determining a reporting quality threshold for a parameter related to channel state information (CSI); performing a measurement for each of a plurality of beams from a first predetermined set of beams for evaluation; evaluating the measurement for each of the plurality of beams against the reporting quality threshold; discontinuing the performing and evaluating of measurements in response to determining that the reporting quality threshold is met for one of the beams, such that one or more beams in the first predetermined set of beams are not measured and evaluated; and reporting, to the wireless communications network, CSI for the one of the beams.

DATA STREAMS WITH DIFFERENT PRIORITIES IN CONTENTION-BASED SYSTEMS

A method by a communication device accesses a shared communication channel using a contention based access protocol. The communication device is configured to transmit data streams with different transmission priorities via the shared communication channel with a first data stream having a higher transmission priority than a second data stream. A method includes observing whether the shared communication channel is available for transmission, where when the shared communication channel is available for transmission, and the communication device waits for the duration of a time interval randomly selected from a time range in which the shared communication channel is available for transmission before the transmission is started. A first time interval is selected from a first time range for the transmission of the first data stream, and a second time interval is selected from a second time range for the transmission of the second data stream wherein the second time range does not overlap with the first time range. 1. A method for accessing , by a communication device , a shared communication channel in which contention based access to the communication channel is used , the communication device being configured to transmit data streams with different transmission priorities via the shared communication channel with a first data stream having a higher transmission priority than a second data stream , comprising:observing whether the shared communication channel is available for transmission, wherein when the shared communication channel is available for transmission, andthe communication device waits for the duration of a time interval randomly selected from a time range in which the shared communication channel is available for transmission before the transmission is started, wherein a first time interval is selected from a first time range for the transmission of the first data stream, and a second time interval is selected from a second time range for the ...

Cleaning Assembly and Method for Tire Curing Mold Having Adjustable Insulation Hood

Invention is a cleaning assembly for cleaning a tire curing mould comprising a turntable () mounted on a base plate (); a cleaning arm () extending on the turntable () in a movable manner and configured to blow dry ice, and an insulation hood () surrounding the cleaning arm () wherein the base plate () is having an adapter support () configured to be gradually widen or narrow for being adapted to the insulation hoods with different diameters on the base plate. 12012502060501216. A cleaning assembly for cleaning a tire curing mould comprising a turntable () mounted on a base plate (); a cleaning arm () extending on the turntable () in a movable manner and configured to blast dry ice , and an insulation hood () encapsulating the cleaning arm () characterized in that the base plate () is having an adapter support () configured to be gradually widen or narrow for being adapted to the insulation hoods with different diameters on the base plate.216186018. A cleaning assembly according to claim 1 , wherein inner face of the adapter support () is having multiple inner grooves () inside one another to hold the insulation hood () from one edge from which is inserted into the inner groove ().318. A cleaning assembly according to claim 2 , wherein the inner grooves () are in form of coaxial rings.418. A cleaning assembly according to claim 2 , wherein the inner grooves () are in form of a spiral.51618201912. A cleaning assembly according to claim 2 , wherein the adapter support () is configured to have an inner groove () at a vicinity of outer side of the turntable () and an outer groove () at a vicinity of outer edge of the base plate ().66020. A cleaning assembly according to the any one of the preceding claims claim 2 , wherein insulation hood () is in a cylindrical form coaxial with the turntable ().71212. A cleaning assembly according to the any one of the preceding claims claim 2 , wherein base plate () is pivotally connected to a carriage () by means of a foldable arm () ...

Method for Cleaning a Full-Mold of Vehicle Tires

The invention is a cleaning method for the production of vehicle tire full-molds having profile. The method as the subject of the invention comprising the process steps respectively, the contaminated full-mold () is taken a pre-treatment with an ultrasonic cleaning apparatus (), depurated full-mold () is re-cleaned by putting to dry ice process in a first cleaning station (), cleaning of the full-mold with preferably multiple number of ultrasonic devices () by immersing into a cleaning liquid () in a second cleaning station (), rinsing by taken in to a rinsing station (), putting to another process by taken in to a passivation station (), and drying by taken in to a drying station (). 11102205152535040607080. A cleaning method for the production of vehicle tire full-molds having profile , characterized in that the process steps comprising respectively , the contaminated full-mold () is taken a pre-treatment with at least one ultrasonic cleaning apparatus () , depurated full-mold () is re-cleaned by putting to dry ice process in a first cleaning station () , cleaning of the full-mold with preferably multiple number of ultrasonic devices ( , , ) by immersing into a cleaning liquid () in a second cleaning station () , rinsing by taken in to a rinsing station () , putting to another process by taken in to a passivation station () , and drying by taken in to a drying station ().2254305020. A cleaning method according to claim 1 , wherein the step of process comprises the depurated full-mold () is suspended on a rack within a basket () in a cabinet () having cleaning liquid () at the second cleaning station ().362260. A cleaning process according to any one of the preceding claims claim 1 , wherein a washing step of process via spraying from at least one jet () onto the depurated full-mold () at the rinsing station ().423010. A cleaning process according to any one of the preceding claims claim 1 , wherein depurated full-mold () is taken into a cabinet () for a process at ...

Sidewall Cleaning Machine for Tire Curing Mold

Invention is a cleaning machine for tire curing sidewall () that comprises a basket (), a rotational base () which mounted into thereof, a nozzle () provided in a movable manner on the rotational base (), of extending towards the open side of the basket () and having an intake () connected to inlet () in a fluid transferrable manner. The cleaning machine comprises a rotating joint () which mounted radially to the outward direction on the rotational base () and a telescopic arm () which carrying the nozzle () at the free end thereof and which of fastened on a rotational base () with the rotating joint (). 18010206020106362402050602040. A cleaning machine for tire curing side mold () that comprises a basket () , a rotational base () which mounted into thereof , a nozzle () provided in a movable manner on the rotational base () , of extending towards the open side of the basket () and having an intake () connected to inlet () in a fluid transferrable manner characterized in that a rotating joint () which mounted radially to the outward direction on the rotational base () and a telescopic arm () which carrying the nozzle () at the free end thereof and which of fastened on a rotational base () with the rotating joint ().22080. A cleaning machine according to claim 1 , wherein rotational base () formed as hollow annular shape and is concentric to sidewall () in an operating position.33031324020. A cleaning machine according to claim 2 , wherein a fixing plate () which fastened with at least one first and second fixing point ( claim 2 ,) at an interior part in a beam forming manner claim 2 , and which of adjusted for mounting from outer part of the rotating joint () which is on the rotational base ().440444244405044204220. A cleaning machine according to the any one of the preceding claims claim 2 , wherein the rotating joint () comprises a bearings () and a slide () claim 2 , that the bearings () which provided at the proximal end of rotating joint () which connected with ...

Cleaning Robot for Tire Curing Mold

Invention is a cleaning robot for cleaning the inner surfaces () of the half mold () of tire curing molds comprising a basket () wherein a lifting arm () placed in a manner pivotal on a proximal end (), the lifting arm () pivoted on a distal end () of a support arm (). The cleaning robot fits completely into the basket () when the positioned as close and comprising a movable head () having a nozzle () coupled in a manner to establish fluid communication to the dry ice inlet () and located at the distal end () of the support arm () and a free end which is configured movably closer to the inner surface () such as at a vicinity of the inner surface () along the contour of its when the positioned as open. 15410505250547010808284767055. A cleaning robot for cleaning the inner surfaces () of the half mold () of tire curing molds comprising a basket () wherein a lifting arm () placed in a manner pivotal on a proximal end () , the lifting arm () pivoted on a distal end () of a support arm (). The cleaning robot fits completely into the basket () when the positioned as close and comprising a movable head () having a nozzle () coupled in a manner to establish fluid communication to the dry ice inlet () and located at the distal end () of the support arm () and a free end which is configured movably closer to the inner surface () such as at a vicinity of the inner surface () along the contour of its when the positioned as open.283708070. A cleaning robot according to claim 1 , wherein horizontal rotatable joint () pivoted to the support arm () providing freedom of movement horizontally at the rotation axis of the movable head () is orthogonal to the elongation axis of the support arm ().3583. A cleaning robot according to claim 2 , wherein the orthogonal rotation axis (R) of the horizontal rotatable joint () is between substantially −20 and +20 degrees.48090706. A cleaning robot according to any of the preceding claims claim 2 , wherein movable head () comprising horizontal ...

Methods, device and node for adapting a numerology depending on a position of a wireless device

A method in a network node for adapting a numerology and slot structure depending on a position of a wireless device is provided. The position of the wireless device is measured by a timing advance (TA). For example, the method comprises: measuring a timing advance value for a User Equipment (UE); selecting a numerology and slot structure for UE data transmission based on the measured timing advance value; and sending an indication of the selected numerology and slot structure to the UE. A network node for carrying out this method is also provided.

Techniques for requesting inter-ue coordination messages for sidelink

Certain aspects of the present disclosure provide techniques for requesting inter-UE coordination messages for sidelink communications. In some cases, a method for wireless communications by a first user equipment (UE), include sending a first sidelink transmission to at least one second UE to trigger the second UE to transmit a report regarding sidelink resource availability and monitoring for a second sidelink transmission from the second UE after sending the first sidelink transmission.

Halogen free and fire-resistant rubber composition and hose

A halogen-free, fire resistant rubber composition for a fire resistant hose includes: 100 parts by weight of elastomer having a blend of: 60 to 70 parts of ethylene vinylacetate elastomer (EVM), a vinylacetate content of EVM being in the range from 60 to 70% by weight; 40 to 30 parts of terpolymer of ethylene, propylene, and a diene elastomer (EPDM), an ethylene content of EPDM being in the range from 30 to 40% by weight and a propylene content of EPDM being from 60 to 70% by weight; at least one fire retardant ingredient; and at least one vulcanizing agent. The vulcanizing agent is a peroxide curative.

Substituted heterocyclic compounds as allosteric modulators of group ii metabotropic glutamate receptors

The present invention provides novel heterocyclic compounds of the general formula (I), including novel compounds of formula (la), and pharmaceutical compositions containing them. Moreover, the compounds of formula (I) or (la) and the pharmaceutical compositions containing them are provided for use in the treatment and/or prophylaxis of conditions associated with altered glutamatergic signalling and/or functions, and/or conditions which can be affected by alteration of glutamate level or signalling in mammals. The compounds of formula (I) or (la) can act as modulators of nervous system receptors sensitive to glutamate, in particular as modulators of metabotropic glutamate receptors (mGluRs), which makes them particularly suitable for the treatment and/or prophylaxis of acute and chronic neurological and/or psychiatric disorders. The present invention further provides compounds of formula (I) or (la) that are modulators of metabotropic glutamate receptors (mGluRs), particularly positive allosteric modulators of mG!uRs, and more specifically positive allosteric modulators of mGluR3.

Container holder for a motor vehicle

BATTERY

A battery may include at least two battery cells and at least two electrical cell contacts for picking up a monitoring signal. The battery may include a main board arranged spaced apart from the battery cells. The main board may include at least two electrical board contacts. The main board may include at least one electronic component configured to process the monitoring signal. The battery may include a flexible conductor track for electrically connecting each cell contact with an associated board contact. The conductor track may include (i) a cell portion connected to the cell contacts and (ii) a board portion connected to the board contacts. The conductor track may include at least two electrical conductors connected to one of the cell contacts and the associated board contact. The battery may include a support plate supporting the board portion of the main board.

Methods of selecting cancer patients for treatment with n,n'-diarylurea compounds and n,n'-diarylthiourea compounds

A method for identifying candidate patients for treatment of cancer with an arylurea compound or an arylthiourea compound by determination of the level of HRI expression or HRI activity in cancer cells from the individual is provided. Embodiments of the present disclosure are directed to methods of identifying cancer patients for treatment with an arylurea compound or an arylthiourea compound. According to one aspect, the term arylyurea compound includes a diarylurea compound and vice versa. According to an additional aspect, the term arylthiourea compound includes a diarylthiourea compound and vice versa.

Macrocyclic inhibitors of hepatitis c virus

Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers thereof, wherein X is N, CH and where X bears a double bond it is C; R 1 is —OR 1 , —NH—SO 2 R 6 ; R 2 is hydrogen, and where X is C or CH, R 2 may also be C 1-6 alkyl; R 3 is hydrogen, C 1-6 alkyl, C 1-6 alkoxyC 1-6 alkyl, or C 3-7 cycloalkyl; R 4 is isoquinolinyl optionally substituted with one, two or three substituents each independently selected from C 1-6 alkyl, C 1-6 alkoxy, hydroxy, halo, polyhaloC 1-6 alkyl, polyhaloC 1-6 alkoxy, amino, mono- or diC 1-6 alkylamino, mono- or diC 1-6 alkylaminocarbonyl, C 1-6 alkylcarbonyl-amino, aryl, and Het; n is 3, 4, 5, or 6; each dashed line (represented by - - - - - ) represents an optional double bond; R 5 is hydrogen; aryl; Het; C 3-7 cycloalkyl optionally substituted with C 1-6 alkyl; or C 1-6 alkyl optionally substituted with C 3-7 cycloalkyl, aryl or with Het; R 6 is aryl; Het; C 3-7 cycloalkyl optionally substituted with C 1-6 alkyl; or C 1-6 alkyl optionally substituted with C 3-7 cycloalkyl, aryl or with Het; each aryl is phenyl optionally substituted with one, two or three substituents; and each Het is a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1 to 4 heteroatoms each independently selected from nitrogen, oxygen and sulfur, and being optionally substituted with one, two or three substituents; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I). Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.

Transport mechanism for a cleaning system of a tyre mould

The invention provides a carriage (1) standing a base (4) thereon; and the base (4) attached to a lifting arm (10) via an upper pivot (11); a basket (50) rotatably hinged manner a transport mechanism comprising a holder part (30) for the tyre molds cleaning device. Transport mechanism comprises intermediate arm (20), extending in order to assembly distal end (12) of the lifting arm (10) and holder part (30) pivoted at one end of its to the holder part (30) from the other end to the distal end (12).

MAGNESIUM ALLOYS CONTAINING RARE EARTH

ligas de magnésio contendo terras-raras a presente invenção refere-se a ligas de magnésio contendo terras-raras que possuem melhor processabilidade, ductilidade ou características de corrosão e adequadas para aplicações forjadas e moldadas por fundição, a liga sendo composta por: y: 2,0% a 6,0% em peso nd: 0,05 a 4,0% em peso gd: 0% a 5,5 % em peso dy: 0% a 5,5% em peso er: 0% a 5,5% em peso zr: 0,05% a 1,0% em peso zn + mn: < 0,11 % em peso, opcionalmente, outras terras-raras e terras-raras pesadas, e o restante consistindo em magnésio e eventuais impurezas, em que o teor total de gd, dy e er é na faixa de 0,3 a 12% em peso, e em que a liga contém baixas quantidades de yb e sm e apresenta uma taxa de corrosão, medida de acordo com a astm b 117, inferior a 0,762 mm/a e/ou em que a área percentual das partículas precipitadas surgidas quando a liga for processada e com um tamanho de partícula médio superior a 1 µm e inferior a 15 µm é inferior a 3%. as ligas podem ser moldadas por fundição, tratadas a quente, forjadas ou usadas como liga de base em compósitos de matriz metálica. magnesium alloys containing rare earths the present invention relates to magnesium alloys containing rare earths which have better processability, ductility or corrosion characteristics and suitable for forged and cast-molded applications, the alloy being composed of: y: 2 , 0% to 6.0% by weight nd: 0.05 to 4.0% by weight gd: 0% to 5.5% by weight dy: 0% to 5.5% by weight r: 0% to 5 , 5% by weight zr: 0.05% to 1.0% by weight zn + mn: <0.11% by weight, optionally, other rare earths and heavy rare earths, and the remainder consisting of magnesium and eventual impurities, in which the total content of gd, dy and er is in the range of 0.3 to 12% by weight, and in which the alloy contains low amounts of yb and sm and has a corrosion rate, measured according to astm b 117, less than 0.762 mm / a and / or where the percentage area of precipitated particles arising when the alloy is processed and ...

Apparatus for prevention of reading of magnetic cards

A card reading machine includes a card reader for reading data on a magnetic card and a device for preventing reading of the data on the magnetic card by illegal card reading devices operatively associated with the card reading machine. The device for preventing may include an oscillator, a driver circuit and a coil for generating electromagnetic signals similar to data on a card. A method for preventing reading of data on a magnetic card by in illegal card reader in operative association with an apparatus having a card reader intended to read the data on the magnetic card includes producing a signal ruining the data collected by the illegal card reader. The apparatus having a card reader may include an insertion slot in which case the method may further include producing the signal near the insertion slot.

Magnesium alloys containing rare earths.

Aleaciones de magnesio que contienen tierras raras que poseen características mejoradas de procesabilidad y/o ductilidad y/o corrosión y son adecuadas para aplicaciones de forjado y vaciado que consisten de: Y: 2.6-60 % en peso, Nd 0-4.0 % en peso, 0-5.5 % en paso, Dy: 0-5.5 % en peso, Er: 0-5.5 % en peso, Zr: 0.05-1.0 % en peso, Zn + Mn: 0.11 % en peso, opcionalmente otras tierras raras y tierras raras pesadas, el resto que es magnesio e impurezas incidentales y el contenido total de Gd, y Er está en el intervalo de 0.3-12 % en peso, en donde ya sea la aleación contiene bajas cantidades de Yb y Sm y exhibe una proporción de corrosión como se mide de acuerdo con ASTM B117 de menos de 30 Mpy, y/o el porcentaje de área de cualquiera de las partículas precipitadas que surgen cuando se procesa la aleación que tiene un tamaño promedio de partícula mayor de 1 um y menor de 15 um es menos de 3 %. Las aleaciones se pueden vaciar y/o tratar térmicamente y/o forjar y/o usar como una aleación base para un producto compuesto de matriz metálica.

Method for monitoring the temperature of a glow plug

Die Erfindung betrifft ein Verfahren zur Regelung der Temperatur einer Glühkerze (1), wobei aus einer Solltemperatur (T Solll ) ein Sollwert (R soll ) einer temperaturabhängigen elektrischen Größe ermittelt wird, und eine durch Pulsweitenmodulation erzeugte Effektivspannung (U eff ) an die Glühkerze (1) angelegt und als Stellgröße verwendet wird. Erfindungsgemäß ist vorgesehen, dass mit einem mathematischen Modell (4) ein erwarteter Wert (R e ) der elektrischen Größe berechnet wird, die elektrische Größe gemessen wird, durch Auswertung des berechneten Wertes (R e ) ein erstes Fehlersignal e 1 (t) erzeugt wird, als Eingangsgröße des mathematischen Modells (4) ein aus dem Wert der Effektivspannung (U eff ) und dem Fehlersignal (e 1 (t)) berechneter Wert verwendet wird, wobei das mathematische Modell (4) aus der Eingangsgröße eine Ausgangsgröße (X) berechnet, die den erwarteten Wert (R e ) der elektrischen Größe vorgibt, mit der Ausgangsgröße (X) des mathematischen Modells (4) ein korrigierter Wert für die Effektivspannung (U eff ) berechnet und die Effektivspannung (U eff ) auf den korrigierten Wert geändert wird. The invention relates to a method for regulating the temperature of a glow plug (1), wherein a nominal value (R soll ) of a temperature-dependent electrical variable is determined from a nominal temperature (T Solll ), and an effective voltage (U eff ) generated by pulse width modulation to the glow plug ( 1) is created and used as a manipulated variable. According to the invention, an expected value (R e ) of the electrical variable is calculated with a mathematical model (4), the electric variable is measured, and a first error signal e 1 (t) is generated by evaluating the calculated value (R e ) , an input value of the mathematical model (4) is a value calculated from the value of the effective voltage (U eff ) and the error signal (e 1 (t)), the mathematical model (4) calculating an output quantity (X) from the input variable which predetermines the ...

substituted quinazolinone derivatives and their use as positive allosteric modulators of mglur4

A presente invenção refere-se a derivados de quinazolinona de fórmula (I), bem como a composições farmacêuticas contendo estes compostos. Os compostos de fórmula (I), (I) como aqui fornecidos, podem atuar como moduladores alostéricos positivos do receptor de glutamato metabotrópico subtipo 4 (mGluR4) e, portanto, podem ser usados como agentes terapêuticos, particularmente no tratamento ou prevenção de condições associadas à sinalização glutamatérgica alterada e/ou funções ou condições que podem ser afetadas pela alteração da sinalização ou nível de glutamato. The present invention relates to quinazolinone derivatives of formula (I), as well as pharmaceutical compositions containing these compounds. The compounds of formula (I), (I) as provided herein, may act as positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and, therefore, may be used as therapeutic agents, particularly in the treatment or prevention of conditions associated with altered glutamatergic signaling and/or functions or conditions that may be affected by altered signaling or glutamate level.

A cell line comprising one or more cells that stably express a nucleic acid sequence encoding a sterol regulatory promoter and that is operably linked to a nucleic acid sequence encoding a detectable tag; and method of determining whether a compound lowers cholesterol.

Línea celular que comprende una o más células que expresan en forma estable una secuencia de ácidos nucleicos que codifica un promotor regulador de esteroles y que está unida en forma operativa a una secuencia de ácidos nucleicos que codifica una etiqueta detectable; y método para determinar si un compuesto reduce el colesterol. A cell line comprising one or more cells that stably express a nucleic acid sequence encoding a sterol regulatory promoter and that is operably linked to a nucleic acid sequence encoding a detectable tag; and method of determining whether a compound lowers cholesterol.

A collaborative robot joint with continuously variable transmission

Nuclear fuel beam with mixed separator types

Haz de combustible nuclear (100) que comprende: una pluralidad de barras de combustible (18,19) dispuestas en un canal en una dirección axial;un separador de tipo rejilla (21) que se extiende el canal en una dirección transversal en una primeraposición axial, pasando al menos una porción de las barras de combustible a través y alineadas por elseparador de tipo rejilla; y un separador de tipo virola (25) que se extiende en el canal en la dirección transversal en una segundaposición axial, siendo la primera posición axial más cercana a una entrada de refrigerante (101) del haz decombustible nuclear que la segunda posición axial, pasando al menos una porción de las barras decombustible a través y alineadas mediante el separador de tipo virola. Nuclear fuel bundle (100) comprising: a plurality of fuel rods (18,19) arranged in a channel in an axial direction; a grid-type spacer (21) extending the channel in a transverse direction in a first position axial, passing at least a portion of the fuel rods through and aligned by the grid-type spacer; and a ferrule-type spacer (25) extending in the channel in the transverse direction at a second axial position, the first axial position being closer to a coolant inlet (101) of the nuclear fuel bundle than the second axial position, passing at least a portion of the fuel rods through and aligned by the ferrule-type spacer.

Application compatibility checking in a distributed computing environment

In various embodiments, methods and systems for maintaining compatibility between applications, based on feature-set constraints are provided. A distributed computing system provides Platform as a service (PaaS) including a software framework in a service model of cloud computing. A known compatibility baseline is established for features of a first application and a second application. The known compatibility baseline inherently includes a baseline set of unenumerated features of the applications. It is determined that the first application is compatible with second application based on comparing an explicit enumeration of added features or removed features in a feature set of the applications. The added features or removed features are tracked after the baseline set of unenumerated features is defined. The determination whether the first application and the second application are compatible is communicated for processing the first application and/or the second application.

A method for defrosting process

The method of the invention is developed for the cooler devices that can detect the time of defrosting, and the initiation time of the defrosting process can be controlled by using this method. In the method of the invention, while the said cooler device continues to operate, the next defrosting time is calculated momentarily depending on the changing inner and outer environment conditions. For the said purposes, the values measured by the inner and outer environment temperature and/or humidity meter are evaluated by the control unit. The time of the next defrosting process is calculated in accordance with the duration that at least one of the compartment doors of the device is kept close.

Multiplexing of subframes with different subcarrier spacings

Methods and apparatus in a fifth-generation wireless communications, including an example method, in a wireless device, that includes receiving a downlink signal comprising an uplink access configuration index, using the uplink access configuration index to identify an uplink access configuration from among a predetermined plurality of uplink access configurations, and transmitting to the wireless communications network according to the identified uplink access configuration. The example method further includes, in the same wireless device, receiving, in a first downlink subframe, a first Orthogonal Frequency-Division Multiplexing (OFDM) transmission formatted according to a first numerology and receiving, in a second downlink subframe, a second OFDM transmission formatted according to a second numerology, the second numerology differing from the first numerology, where the first numerology has a first subcarrier spacing and the second numerology has a second subcarrier spacing, the first subcarrier spacing differing from the second subcarrier spacing. Variants of this method, corresponding apparatuses, and corresponding network-side methods and apparatuses are also disclosed.

Sonic state control sensor

A state control sensor comprising a transmitter (1) transmitting signals to a medium and a receiver (2) receiving signals from the medium for detecting if any change in state occurred in the medium, characterized in that the sensor is set to an initial state value by transmitting sonic frequency signals to the medium and receiving sonic frequency signals from the medium, and a change in state is detected when the subsequent state value corresponding to the signal received by the receiver (2) in subsequent sensing cycle is different than the initial state value.

A self service terminal, an anti-skimming unit, a card reader device, a bezel, a method of jamming and use of an anti-skimming unit

The invention relates to a self service terminal, such as an Automated Teller Machine, comprising a front panel provided with a card insertion slot for inserting a magnetic card therethrough, wherein, during insertion through the insertion slot, a magnetic stripe on the card induces a card data flux into a stripe data reading zone. The terminal also comprises an anti- skimming unit for generating a jamming field so as to jam a magnetic recording unit of an illegal card reader installed near or in the card insertion slot of the front panel. The anti-skimming unit includes a first magnetic field source and at least one further magnetic field source, each source inducing a electro- magnetic field in a slot region including the card insertion slot, such that the jamming field in the stripe date reading zone deviates from the jamming field outside the stripe data reading zone.

Chlorination of sucrose-6-esters

There is provided a method for the chlorination of a sucrose-6-acylate to produce a 4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose-6-acylate, wherein said method comprises the following steps (i) to (v): (i) providing a first component comprising sucrose-6-acylate; (ii) providing a second component comprising a chlorinating agent; (iii) combining said first component and said second component to afford a mixture; (iv) heating said mixture for a heating period in order to provide chlorination of sucrose- 6-acylate at the 4, 1' and 6' positions thereof; (v) quenching said mixture to produce a 4,1',6'-trichloro-4,1',6'-trideoxy- galactosucrose-6-acylate; wherein at least one of said first component and said second component comprises a reaction vehicle, and said reaction vehicle comprises a tertiary amide; and wherein said mixture comprises a cosolvent during a least a portion of the heating period of step (iv), wherein said cosolvent comprises perfluorooctane.

Antibacterial Quinoline Derivatives

The precent invention relates to novel substituted quinoline derivatives according to the general formula (Ia) or formula (Ib): including any stereochemically isomeric form therof, a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof, The claimed compounds are useful for the treatment of a bacterial infection. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of a bacterial infection and a process for preparing the claimed compounds.

Cell based quality control bioassays for nutriceutical and medicinal products

Macrocyclic inhibitors of hepatitis c virus

Electric toothbrush has rotary brush head driven by electric motor in handle and with radially extending bristles

The electric toothbrush has a brush head (16) with radially extending bristles mounted for rotation about an axis (18). The toothbrush can have a motor in the handle (10) and the rotational axis of the brush head is parallel to the handle. The brush head and the handle containing the motor can be separable. The toothbrush can have a cap (34) to surround the brush head.

Antibacterial quinoline derivatives.

La presente invención se relaciona con novedosos derivados de quinolina sustituida de conformidad con la fórmula general (la) o la fórmula (Ib): (ver fórmulas Ia Ib) incluyendo cualquier forma estereoquímicamente isomérica de los mismos, un N-óxido de los mismos, una sal aceptable para uso farmacéutico de los mismos o un solvato de los mismos; los compuestos reivindicados son útiles para el tratamiento de una infección bacteriana; también se reivindica una composición que comprende un vehículo aceptable para uso farmacéutico y, como ingrediente activo, una cantidad terapéuticamente efectiva de los compuestos reivindicados; el uso de los compuestos o composiciones reivindicados para la elaboración de un medicamento para el tratamiento de una infección bacteriana y un procedimiento para la preparación de los compuestos reivindicados.

Apparatus for prevention of reading of magnetic cards

A collaborative robot joint with continuously variable transmission

Refrigerator with improved preservation of vegetables and fruits

The present invention relates to a refrigerator (1) comprising: a compartment (2) for refrigerating vegetables and fruits stored therein; an illuminating unit (3) which comprises one or more light sources (4) that are adapted to illuminate the compartment (2) with light for extending the shelf life of the vegetable and the fruits stored therein; and a control unit for controlling the illuminating unit (3).

Chlorination of sucrose-6-esters

There is provided a method for the chlorination of a sucrose-6-acylate to produce a 4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose-6-acylate, wherein said method comprises the following steps (i) to (v): (i) providing a first component comprising sucrose-6-acylate; (ii) providing a second component comprising a chlorinating agent; (iii) combining said first component and said second component to afford a mixture; (iv) heating said mixture for a heating period in order to provide chlorination of sucrose-6-acylate at the 4, 1' and 6' positions thereof; (v) quenching said mixture to produce a 4,1',6'-trichloro-4,1',6'-trideoxy- galactosucrose-6-acylate; wherein at least one of said first component and said second component comprises a reaction vehicle, and said reaction vehicle comprises a tertiary amide; and wherein said mixture comprises a cosolvent during a least a portion of the heating period of step (iv), wherein said cosolvent comprises dimethylacetamide (DMAc).

SECURE ACCESS TO DATA IN A DEVICE

A collaborative robot joint with continuously variable transmission

The invention is a collaborative robot joint with continuously variable transmission, is related to two spheres (1, 2) which are located on the housings (81) on the carrying structure (8) for providing transmission between the input/output conical variators (10), a changed transmission ratio by means of changing the locations of these spheres (1, 2) on the conical variators (10) in a linear manner, the compression springs (6) with adjustable compression value in order to guarantee these spheres (1, 2) providing the transmission in both directions by means of friction, the adjusting screw (7) which provides changing the compression amount of the compression springs (6) for adjusting the highest transmittable torque value, the spherical bearings (3) which would allow the spheres (1, 2) to rotate with least amount of friction in both transmission directions and in the direction of progress for changing the transmission amount, not requiring the rotation of the inlet/outlet conical variations (10) during the transmission ratio change by means of the rotation of the spheres (1, 2) in two directions.

NETWORK NODE, METHODS FOR A NETWORK NODE AND WIRELESS DEVICE, AND WIRELESS DEVICE.

são providos um dispositivo sem fio, um nó de rede e métodos que usam duplex por divisão de tempo do novo rádio, nr-tdd. em uma modalidade, o nó de rede inclui um sistema de circuitos de processamento configurado para configurar a colocação das mensagens de controle em enlace descendente sobre pelo menos dois símbolos de um intervalo nr tdd. os pelo menos dois símbolos são símbolos diferentes no domínio do tempo. a wireless device, a network node and methods using time division duplex from the new radio, nr-tdd, are provided. in one embodiment, the network node includes a system of processing circuits configured to configure the placement of control messages on the downlink over at least two symbols of a nd tdd interval. the at least two symbols are different symbols in the time domain.

A method of regulating defrost operation in cooling devices

The method according to the present invention is developed for cooling devices capable to detect defrost time, wherein the starting time of a defrost process is regulated by this method. In a first step of this method, the data indicating that new foodstuff is placed to the freezer compartment of a cooling device is entered to the control unit of the cooling device by a user, then in a second step following this data entry, the device keeps continuing the cooling process, and thereafter in a third step, the user is alerted by means of a signal generator connected to the control unit after a while. In a fourth step of this method, new foodstuffs are put to the freezer compartment after said alert, and the cooling process is continued, and in a fifth step, if it is determined by the device that it is time to perform a defrost operation after new foodstuff is loaded to the compartment, the defrost operation can be delayed to a future time.

Centrifugal pump driven by electric motor, has central temperature sensor removably inserted into bore in rear wall of motor housing enclosing stator chamber

The pump has a slotted tube (3), especially a slotted pot, dividing a wet chamber with a rotor from a dry stator chamber, in which a sensor (12) is arranged immediately next to the slotted tube to detect pump or system parameters, especially a temperature. The sensor is removably inserted into a bore (7) in the rear wall of the motor housing enclosing the stator chamber.

Flap arrangement for cooling devices

The cooling device (A) of the invention, which is used for storing food stuff, comprises at least one cooling compartment (1) and freezing compartment (2); a single cooling system adjusting the compartment (1, 2) temperatures; at least one temperature sensor (3) that measures cooling compartment temperature; a control unit regulating the operation of the cooling system, which is associated with the cooling system and said sensor. The device (A) also comprises at least one temperature sensor (4) which measures external ambient temperature of the device and is associated with the control unit; at least one flap arrangement (8) associated with the control unit, which allows air intake into the cooling compartment (1) in accordance with the value measured by said sensor (4).

Azaindazole-5 derivatives and their use

Control rod guide tube and method for providing coolant to a nuclear reactor fuel assembly

Aspartyl protease inhibitors

A compound of formula (I) N-oxides, addition salts, quaternary amines metal complexes stereochemically isomeric forms and metabolites thereof, wherein A is CR 1 Or N; formula (A) or formula (B) D is H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, G is NR 10 or O Q is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 Cycloalkyl, aryl or heterocyclyl; W is H, C 1 -C 6 alkyl, C 3 -C 6 Cycloalkyl, CH 2 F, CHF 2 or CF 3 ; one of X' and X" is H or CH 3 , the other is C 1 -C 3 alkyl, F, OH, NRaRb, CF 3 or N 3 ; or X' and X" are both F; Y is NRd or O; Z is O, NRa, CHRd, CF 2 or S(=0)r or a bond; the other variables are as defined in the specification. The compounds of the invention are inhibitors of BACE and are among other things useful for the treatment and/or prevention of conditions associated with BACE activity such as Alzheimer's disease.

Antibacterial quinoline derivatives

THE PRESENT INVENTION RELATES TO NOVEL SUBSTITUTED QUINOLINE DERIVATIVES ACCORDING TO THE GENERAL FORMULA (IA) OR FORMULA (IB): INCLUDING ANY STEREOCHEMICALLY ISOMERIC FORM THEREOF, WHEREIN 10 Q REPRESENTS A RADICAL OF FORMULA A N-OXIDE THEREOF, A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF OR A SOLVATE THEREOF. THE CLAIMED COMPOUNDS ARE USEFUL FOR THE TREATMENT OF A BACTERIAL INFECTION. ALSO CLAIMED IS A COMPOSITION COMPRISING A PHARMACEUTICALLY ACCEPTABLE CARRIER AND, AS ACTIVE INGREDIENT, A THERAPEUTICALLY EFFECTIVE AMOUNT OF THE CLAIMED COMPOUNDS, THE USE OF THE CLAIMED COMPOUNDS OR COMPOSIT IONS FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF A BACTERIAL INFECTION AND A PROCESS FOR PREPARING THE CLAIMED COMPOUNDS.

Prostaglandin E2 (PGE2) EP4 receptor antagonists

The present invention relates to novel compounds of formula (I) and pharmaceutical compositions containing these compounds. The compounds provided herein can act as prostaglandin E2 (PGE2) EP4 receptor antagonists, which renders them highly advantageous for use in therapy, particularly in the treatment or prevention of cancer, a neovascular eye disease, inflammatory pain, or an inflammatory disease, such as, e.g., multiple sclerosis, rheumatoid arthritis or endometriosis.

Individual updating of computer programs

Sidecar-based integration capabilities for containerized applications

Methods and systems for improved integration functions for applications are provided. In one embodiment, a method is provided that includes receiving a request to execute an application. The request may specify a primary container image for the application and a secondary container image for an integration function used by the application. A primary container may be created for execution of the primary container image and a secondary container image may be created for execution of the secondary container image. The primary and secondary containers may be executed to implement the application.

computer storage method, system, and medium to maintain application compatibility based on assignment set restrictions

resumo patente de invenção: "verificação de compatibilidade de aplicativo em um ambiente de computação distribuído". a invenção diz respeito a métodos e a sistemas para manter compatibilidade entre aplicativos, com base em restrições de conjunto de atribuições. um sistema de computação distribuído proporciona plataforma como um serviço (paas) incluindo uma estrutura de software em um modelo de serviço de computação em nuvem. uma linha de base de compatibilidade conhecida é estabelecida para atribuições de um primeiro aplicativo e de um segundo aplicativo. a linha de base de compatibilidade conhecida inerentemente inclui um conjunto de linha de base de atribuições não enumeradas dos aplicativos. é determinado que o primeiro aplicativo é compatível com o segundo aplicativo baseado em comparar uma enumeração explícita de atribuições adicionadas ou de atribuições removidas em um conjunto de atribuições dos aplicativos. as atribuições adicionadas ou as atribuições removidas são rastreadas após o conjunto de linha de base de atribuições não enumeradas ser definido. a determinação de se o primeiro aplicativo e o segundo aplicativo são compatíveis é comunicada para o processamento do primeiro aplicativo e/ou do segundo aplicativo.

Fuel support and method for modifying coolant flow in a nuclear reactor

Method for monitoring the temperature of a glow plug

Quinoline derivatives as antibacterial agents

Anvendelse av en forbindelse for fremstilling av et medikament for behandling av en bakteriell infeksjon, forutsatt at den bakterielle infeksjon er noe annet enn en mykobakteriell infeksjon, hvor nevnte forbindelse er en forbindelse med formel (Ia) eller (Ib) et farmasøytisk akseptabelt syre- eller baseaddisjonssalt derav, en stereokjemisk isomer form derav, en tautomer form derav eller en N-oksidform derav, hvori Rer hydrogen, halogen, halogenalkyl, cyano, hydroksy, Ar, Het, alkyl, alkyloksy, alkyltio, alkyloksyalkyl, alkyltioalkyl, Ar-alkyl eller di(Ar)alkyl; p er 1, 2, 3 eller 4; Rer hydrogen, hydroksy, merkapto, alkyloksy, alkyloksyalkyloksy, alkyltio, mono- eller di(alkyl)amino eller et radikal med formel. Rer alkyl, Ar, Ar-alkyl, Het eller Het-alkyl; q er 1,2 eller 3; R og R er hydrogen, alkyl eller benzyl; eller R og Rsammen og iberegnet N-atomet som de er bundet til, kan danne en ring; Rer hydrogen, halogen, halogenalkyl, hydroksy, Ar, alkyl, alkyloksy, alkyltio, alkyloksyalkyl, alkyltioalkyl, Ar-alkyl eller di(Ar)alkyl; eller to nærliggende R6-radikaler kan være tatt sammen og danner et toverdig radikal med formel -CH=CH-CH=CH-; r er 1, 2, 3, 4 eller 5; Rer hydrogen, alkyl, Ar eller Het; Rer hydrogen eller alkyl; Rer okso; eller Rog Rsammen danner radikalet -CH=CH-N=.

Antibacterial quinoline derivatives

The present invention relates to substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): including any stereochemically isomeric form thereof, a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. The claimed compounds are useful for the treatment of a bacterial infection. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of a bacterial infection and a process for preparing the claimed compounds..

Electrical plug area of an electric motor

The invention relates to an electric motor (1) for driving a pump, particularly a circulating pump for heating systems, having a motor housing (2) made of metal and a plug area (3) comprising an electrical plug part (4) having a plurality of plug contacts (5, 6) that can be plugged into mating plug contacts (29) of a mating plug area (30) of an electronics housing (28) of the electric motor (1). The plug part (4) is held in a floatingly movable manner on the motor housing (2), so that the assembly of the electronic housing (28) on the electric motor (1) can be done simply and without damage.

A process for preparing a composition containing at least one metal-amino acid compound and composition obtainable by such a process

Die Erfindung betrifft ein Verfahren zur Herstellung einer Zusammensetzung enthaltend zumindest eine Metall-Aminosäure-Verbindung, bei dem- zunächst eine basische Verbindung eines zweiwertigen Metalls zusammen mit einer alpha-Aminosäure im molaren Verhältnis von eins zu wenigstens zwei in Wasser unter Erhitzung auf 60 °C bis 100 °C zur Reaktion gebracht wird,- abgewartet wird, bis sich ein Reaktionsgleichgewicht eingestellt hat,- anschließend die Reaktionslösung mit einem wasserlöslichen Salz desselben zweiwertigen Metalls in einer Menge versetzt wird, dass die molare Gesamtmenge des zweiwertigen Metalls aus der basischen Verbindung des Metalls und dem Metallsalz die molare Menge der alpha-Aminosäure nicht übersteigt,- abgewartet wird, bis sich das Metallsalz vollständig gelöst hat,- danach die Reaktionslösung unter Erhalt einer Feststoffzusammensetzung getrocknet wird. The invention relates to a process for the preparation of a composition comprising at least one metal-amino acid compound in which first a basic compound of a divalent metal together with an alpha-amino acid in a molar ratio of one to at least two in water with heating to 60 ° C. - Waited until a reaction equilibrium has set, - Then the reaction solution is added to a water-soluble salt of the same bivalent metal in an amount such that the total molar amount of divalent metal from the basic compound of the metal and the metal salt does not exceed the molar amount of the alpha-amino acid, is allowed to stand until the metal salt has completely dissolved, then the reaction solution is dried to obtain a solid composition.

Additive manufacturing of thermoplastic composites at ambient conditions

A method for creating a thermoplastic element by additive manufacturing is presented which includes the steps of: a) providing a resin mixture that at least includes a resin and at least one photo-initiator species in which the resin mixture is liquid at substantially room temperature; b) curing the resin mixture at substantially room temperature using UV-light. The resin mixture for use in the method for manufacturing a thermoplastic element, is substantially liquid at room temperature, and includes at least one photo-initiator species. A device for manufacturing a thermoplastic element is presented that at least includes a preferably moveable nozzle for extruding the resin mixture and a UV-light source arranged at or near an outlet of the nozzle for curing the extruded resin mixture.

A washing machine with transport support equipment

The present invention relates to a washing machine (1) comprising a body (2); a drum wherein the laundry is loaded; a tub (3) wherein the drum moves; at least two fastening slots (4) which are arranged at the right and left sides of the rear wall of the body (2); a transport support equipment having at least two fastening bolts (5) which are inserted through the fastening slots (4) to be bolted to the tub (3) and which prevent the tub (3) from hitting the body (2) during transport; and a fastening wire (6) which is connected to the fastening bolts (5).

Apparatus for prevention of reading of magnetic cards

Magnesium alloys containing rare earths

Magnesium alloys containing rare earths which possess improved processability and/or ductility and/or corrosion characteristics and suitable for wrought and cast applications consisting of: Y: 2.0 - 6.0 % by weight Nd: 0 - 4.0 % by weight Gd: 0 - 5.5 % by weight Dy: 0 - 5.5 % by weight Er: 0 - 5.5 % by weight Zr: 0.05 -1.0 % by weight Zn + Mn:< 0.11 % by weight, optionally other rare earths and heavy rare earths, the balance being magnesium and incidental impurities and the total content of Gd, Dy and Er is in the range of 0.3 - 12 % by weight, wherein either the alloy contains low amounts of Yb and Sm and exhibits a corrosion rate as measured according to ASTM B117 of less than 30 Mpy, and/or the area percentage of any precipitated particles arising when the alloy is processed having an average particle size greater than 1 µm and less than 15 µm is less than 3%. The alloys can be cast and / or heat treated and / or wrought and/or used as a base alloy for a metal matrix composite.

A cleaning robot for tire curing mold

Method for monitoring the temperature of a glow plug

Die Erfindung betrifft ein Verfahren zur Regelung der Temperatur einer Glühkerze (1), wobei aus einer Solltemperatur (T Solll ) ein Sollwert (R soll ) einer temperaturabhängigen elektrischen Größe ermittelt wird, und eine durch Pulsweitenmodulation erzeugte Effektivspannung (U eff ) an die Glühkerze (1) angelegt und als Stellgröße verwendet wird. Erfindungsgemäß ist vorgesehen, dass mit einem mathematischen Modell (4) ein erwarteter Wert (R e ) der elektrischen Größe berechnet wird, die elektrische Größe gemessen wird, durch Auswertung des berechneten Wertes (R e ) ein erstes Fehlersignal e 1 (t) erzeugt wird, als Eingangsgröße des mathematischen Modells (4) ein aus dem Wert der Effektivspannung (U eff ) und dem Fehlersignal (e 1 (t)) berechneter Wert verwendet wird, wobei das mathematische Modell (4) aus der Eingangsgröße eine Ausgangsgröße (X) berechnet, die den erwarteten Wert (R e ) der elektrischen Größe vorgibt, mit der Ausgangsgröße (X) des mathematischen Modells (4) ein korrigierter Wert für die Effektivspannung (U eff ) berechnet und die Effektivspannung (U eff ) auf den korrigierten Wert geändert wird.

Antibacterial quinoline derivatives

The present invention relates to novel subst ituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): including any stereochemically isomeric form thereof, wherein 10 Q represents a radical of formula a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. The claimed compounds are useful for the treatment of a bacterial infection. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or composit ions for the manufacture of a medicament for the treatment of a bacterial infection and a process for preparing the claimed compounds.

Apparatus for prevention of reading of magnetic cards

This is an apparatus utilized for prevention of proper functioning of another card circuit in the same field and of data on cards from becoming accessible by others in this way by way of forming an electromagnetic field by application of voltage at a certain frequency on an inductive charge.

Secure messaging

Un método realizado por un aparato de envío, comprendiendo dicho método: - generar un mensaje que comprende una pluralidad de elementos de información de carga útil cifrados, en donde cada uno de dicha pluralidad de elementos de información de carga útil cifrados se puede descifrar con una clave de descifrado respectiva de una pluralidad de claves de descifrado, en donde dicha clave de descifrado respectiva de la pluralidad de claves de descifrado es diferente para cada uno de dicha pluralidad de elementos de información de carga útil cifrados, en donde dicha pluralidad de elementos de información de carga útil cifrados comprende al menos un primer elemento de información de carga útil cifrado y un segundo elemento de información de carga útil cifrado, en donde dicho primer elemento de información de carga útil cifrado se puede descifrar con una primera clave de descifrado y el segundo elemento de información de carga útil cifrado se puede descifrar con una segunda clave de descifrado diferente de dicha primera clave de descifrado, - determinar si al menos un receptor puede acceder a uno o más de dichos elementos de información de carga útil cifrados de dicha pluralidad de elementos de información de carga útil cifrados, en donde a diferentes receptores de dicho mensaje se les permite acceder a elementos de información de carga útil cifrados parcialmente diferentes de dicha pluralidad de elementos de información de carga útil cifrados, - generar al menos un conjunto de claves de descifrado para dicho al menos un receptor, en donde dicho al menos un conjunto de claves de descifrado para dicho al menos un receptor comprende una clave de descifrado respectiva de dicha pluralidad de claves de descifrado para cada uno de dichos uno o más de dichos elementos de información de carga útil cifrados de dicha pluralidad de elementos de información de carga útil para los que se determina que dicho al menos un receptor tenga permiso para acceder y enviar dicho mensaje a dicho al ...

Systems and methods for designing kinetic shapes