29-12-2016 дата публикации
Номер: US20160374950A1
Принадлежит:
Therapeutic formulations are described for use in the treatment of chronic obstructive pulmonary disease, bronchial asthma, cystic fibrosis, chlorine inhalation, influenza and acute myocardial infarction. The formulations comprise polymeric nanoparticles or polymeric nanoparticles encapsulated within cross-linked polymeric hydrogel microparticles, wherein the polymeric nanoparticles carry a therapeutic agent suitable for treatment of chronic obstructive pulmonary disease, bronchial asthma, cystic fibrosis, chlorine inhalation, influenza, acute myocardial infarction and heart failure. Preferred formulations are inhalable, dry powder therapeutic formulations, which are able to swell on administration to the lungs of a patient. 1. A method of treatment of a disorder , selected from chronic obstructive pulmonary disease , bronchial asthma , cystic fibrosis , chlorine inhalation , influenza and acute myocardial infarction , the method comprising administering a pharmaceutical formulation comprising polymeric nanoparticles or polymeric nanoparticles encapsulated within cross-linked polymeric microparticles , wherein the polymeric nanoparticles carry a therapeutic agent suitable for treatment of the disorder loaded within them to a patient in need thereof.2. The method of claim 1 , wherein the pharmaceutical formulation is an inhalable claim 1 , dry powder pharmaceutical formulation claim 1 , an oral pharmaceutical formulation or an injectable pharmaceutical formulation.3. The method of claim 1 , wherein the nanoparticles have a mean particle diameter of from 1 to 500 nm and wherein the cross-linked microparticles have a mean particle diameter from 1 to 5 μm for inhalable formulations claim 1 , and from 1 to 500 μm claim 1 , most preferably from 1 to 250 μm for oral formulations.4. The method of claim 1 , wherein the microparticles comprise a pH responsive carrier.5. The method of claim 1 , wherein the polymeric nanoparticles comprise a chitosan or a chitosan-derivative ...
Подробнее