NANOHOLE ARRAY BASED SENSORS WITH VARIOUS COATINGS AND TEMPERATURE CONTROL FOR COVID-19

A nanohole array (NHA)-based plasmonic sensor (e.g., liquid/condensed phase sensor), their preparation, and their use to detect and analyze liquid samples, especially mixtures of chemicals and/or bio-chemicals and/or infectious diseases (e.g., viruses such as SARS-CoV-2 (COVID-19)). 1. A nanohole-array based plasmonic condensed phase sensor comprising:i) a substrate at least partially covered with a deposit;ii) a plasmonic layer on the deposit; andiii) one or more functional layers on the plasmonic layer;wherein the sensor comprises a plurality of nanoholes, andwherein the sensor further comprises one or more channels.2. The sensor according to claim 1 , wherein the one or more channels guide a condensed phase sample to be tested to the sensing area of the sensor.3. The sensor according to claim wherein the sample is a condensed breath specimen collected from a subject being tested.4. The sensor according to claim 1 , wherein the sensor comprises one claim 1 , two or three channels.5. The sensor according to claim 1 , wherein each channel is functionalized with one or more of the following reagents:i) Antibody that binds to SARS-CoV-2;ii) Antibody that binds to influenza virus.6. The sensor according to wherein the sensor comprises two channels claim 1 , one coated with antibody that binds to SARS-CoV-2 and the other coated with an antibody that binds to influenza virus.7. The sensor according to claim 1 , wherein the substrate is an etchable substrate.8. The sensor according to claim 1 , wherein the substrate is silicon.9. The sensor according to claim 1 , wherein the substrate is covered with a deposit selected from SiN claim 1 , SiO claim 1 , and a combination thereof.10. The sensor according to claim 1 , wherein the deposit is SiN.11. The sensor according to claim 1 , wherein the deposit has a thickness of between about 20 nm and about 600 nm.12. The sensor according to claim 1 , wherein the plasmonic layer comprises gold claim 1 , silver claim 1 , copper claim ...

POLYMERS AND POLYMERIC ASSEMBLIES FOR PEPTIDE AND PROTEIN ENCAOSULATION AND RELEASE, AND METHODS THEREOF

The invention provides polymers and polymeric nanogels that stably encapsulate peptides and proteins, which are controllably released upon degradable of the nano-structures in response to specific microenvironment, and compositions and methods of preparation and use thereof. 1. A crosslinked polymeric nanogel-protein conjugate adapted to stably transporting a protein across a cell membrane and then intracellularly releasing the protein with intact biological activity.2. The crosslinked polymeric nanogel-protein conjugate of claim 1 , wherein the protein is securely encapsulated inside an aggregate formed by the self-crosslinked polymeric nanogel.3. The crosslinked polymeric nanogel-protein conjugate of claim 1 , wherein the protein is securely conjugated on a surface of the nanoaggregate formed by the self-crosslinked polymeric nanogel.4. The crosslinked polymeric nanogel-protein conjugate of claim 2 , wherein the protein is encapsulated inside the nanoaggregate by one or more disulfide linkages.5. The crosslinked polymeric nanogel-protein conjugate of claim 3 , wherein the protein is conjugated to the surface of the nanoaggregate by one or more disulfide linkages.6. The crosslinked polymeric nanogel-protein conjugate of claim 1 , wherein the protein is a cytosolically active protein.7. The crosslinked polymeric nanogel-protein conjugate of claim 1 , wherein the protein is caspase.8. The crosslinked polymeric nanogel-protein conjugate of claim 1 , wherein the conjugate is further functionalized with a targeting ligand.9. The crosslinked polymeric nanogel-protein conjugate of claim 8 , wherein the targeting ligand is an antibody protein claim 8 , a peptide claim 8 , or a small molecule.10. The crosslinked polymeric nanogel-protein conjugate of claim 8 , wherein the targeting ligand is a peptide.11. The crosslinked polymeric nanogel-protein conjugate of claim 8 , wherein the conjugate is functionalized with a cell penetrating peptide.12. The crosslinked polymeric ...

Lectins and uses thereof

Provided herein are chemical compounds, methods for their discovery, and their therapeutic and research use. Further provided herein are antiviral and antimicrobial lectin compounds and methods of their use.

Small molecule inhibitors of mcl-1 and uses thereof

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having benzoic acid structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.

FUROXAN-BASED COMPOUNDS AND USES THEREOF

Described herein are compounds of the formula (I), as well as pharmaceutical compositions comprising such compounds, and methods for using such compounds/pharmaceutical compositions for treating neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease, and multiple sclerosis (MS). 8. A pharmaceutical composition comprising at least one compound of and a pharmaceutically acceptable excipient.9. A method for treating a neurodegenerative disease claim 1 , the method comprising administering a therapeutically effective amount of at least one compound of claim 1 , or a pharmaceutically acceptable salt claim 1 , polymorph claim 1 , prodrug claim 1 , solvate or clathrate thereof.10. The method of claim 9 , wherein the neurodegenerative disease is Alzheimer's disease claim 9 , Parkinson's disease claim 9 , Huntington's disease or multiple sclerosis (MS).11. A method for inhibiting caspase-6 with a compound that reacts with the sulfhydryl group (SH) on cysteine 246 of caspase-6 claim 9 , the method comprising contacting caspase-6 with an effective amount of said compound. This application claims the benefit of U.S. Provisional Patent Appl. Ser. No. 62/616,160, filed Jan. 11, 2018, which application is incorporated by reference as if fully set forth herein.Caspases comprise a family of cysteine protease enzymes with a well-known role as key mediators in apoptosis signaling pathways and cell disassembly. Interleukin converting enzyme (ICE), also known as Caspase-1, was the first identified caspase. In humans, 11 other known caspases have been further identified. Caspases have been classified in two general groups according to their effects: proapoptotic (caspase-2, 3, 6, 7, 8, 9, 10) and proinfiammatory (caspase-1, 4, 5, 11, 12) caspases. The proapoptotic caspases have been divided in initiators (caspase-2, 8, 9, 10) also known as group II, and executioners (caspase-3, 6, 7) of the apoptotic process or group III. The Interleukin ...

Wholly microfabricated biosensors and process for the manufacture and use thereof

An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments. The present invention also discloses a novel method for the electrochemical detection of particular analyte species of biological and physiological significance using an substrate/label signal generating pair which produces a change in the concentration of electroactive species selected from the group consisting of dioxygen and hydrogen peroxide.

Instant stain removing device, formulation and absorbent means

A device for applying stain formulation to a garment or article of clothing while it is being worn is disclosed. The device includes a reservoir with a valve assembly for dispensing an effective stain removal formulation directly to the stain, spot or mark. The device also includes a shell accommodating absorbent pads. After the stain removal formulation is applied, an absorbent pad is pressed and/or rubbed on the stain to lift and remove the stain and to absorb or wick excess fluid thereby reducing the amount of time the resulting wet spot takes to dry. Effective stain removing formulations for on-the-go use are also disclosed.

Wholly microfabricated biosensors and process for the manufacture and use thereof

An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments. The present invention also discloses a novel method for the electrochemical detection of particular analyte species of biological and physiological significance using an substrate/label signal generating pair which produces a change in the concentration of electroactive species selected from the group consisting of dioxygen and hydrogen peroxide.

Multi-mode light detection system

Apparatus and methods for combining multiple modes and methods of optical detection, postprocessing, and/or feedback loops in bioanalytical measurements. The methods may include (1) positioning a composition at an examination site in a multi-mode instrument; (2) detecting light transmitted form the composition using the multi-mode instrument in a first optical measurement mode; (3) detecting light transmitted from the composition using the multi-mode instrument in a second optical measurement mode, the second mode being different than the first mode; and (4) computing a quantity related to a property of the composition using the light detected in at least one of the optical measurement modes. These steps may be performed on one or more samples, simultaneously and/or sequentially. The quantity may relate to photoluminescence, chemiluminescence, absorption, and/or scattering, among others.

Eco-friendly laundry pretreatment compositions

An eco-friendly liquid composition for pretreatment of fabrics is disclosed. The composition may include one or more nonionic surfactants, water, and optional ingredients such as a small amount of anionic surfactant, protease enzyme, borax, pH adjusting agent, fragrance, and preservative. The one or more nonionic surfactants may include alkyl polyglycoside. If nonionic surfactants other than the alkyl polyglycoside are included, at least 60% of the total nonionic surfactant in the composition is alkyl polyglycoside. The composition may have a Natural Index of at least 98% as defined herein. The composition may be essentially free of any propellant and bleach component.

Wholly microfabricated biosensors and process for the manufacture and use thereof

An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments. The present invention also discloses a novel method for the electrochemical detection of particular analyte species of biological and physiological significance using a substrate/label signal generating pair which produces a change in the concentration of electroactive species selected from the group consisting of dioxygen and hydrogen peroxyde.

Window component extrusion

ELECTRICAL SWITCHING DEVICE

Wholly microfabricated biosensors and process for the manufacture and use thereof

An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments. The present invention also discloses a novel method for the electrochemical detection of particular analyte species of biological and physiological significance using an substrate/label signal generating pair which produces a change in the concentration of electroactive species selected from the group consisting of dioxygen and hydrogen peroxide.

Eco-friendly laundry pretreatment compositions

An eco-friendly liquid composition for pretreatment of fabrics is disclosed. The composition may include one or more nonionic surfactants, water, and optional ingredients such as a small amount of anionic surfactant, protease enzyme, borax, pH adjusting agent, fragrance, and preservative. The one or more nonionic surfactants may include alkyl polyglycoside. If nonionic surfactants other than the alkyl polyglycoside are included, at least 60% of the total nonionic surfactant in the composition is alkyl polyglycoside. The composition may have a Natural Index of at least 98% as defined herein. The composition may be essentially free of any propellant and bleach component.

Stable enzyme-containing aqueous laundry prespotting composition

A stable enzyme containing aqueous laundry prespotting composition is substantially free of conventional enzymatic stabilizers. The aqueous composition includes a chelating agent, a nonionic surfactant and a detergent enzyme.

Display stand assembly

A display stand assembly is provided which includes elongate upright support members and a plurality of horizontally disposed, vertically spaced product-support units removably mounted on the support members. Any unit may be readily assembled on or disassembled independently from the support members without disturbing adjoining units disposed above or below same.

Aqueous emulsion pre-spotting composition

An emulsion pre-spotting composition having superior effectiveness against both oil-borne and water-borne stains utilizing a relatively low amount of solvent and a mixture of nonionic surfactants.

Commuter route selection system

A commuter route selection system (10) includes a portable device (12) for receiving a travel time for at least one preselected commuter route and disseminating the travel time to a user and a central facility (14) for storing the at least one preselected commuter route and for obtaining current traffic information for the preselected commuter route. The central facility (14) transmits a current travel time for the preselected commuter route to the portable device (12).

Stable enzyme-containing aqueous laundry prespotting composition

A stable, enzyme-containing aqueous laundry prespotting composition. The composition includes at least one detergent enzyme in an amount effective to reduce fabric stains; an enzyme stabilizing system effective to preserve the detergent enzyme for at least 12 weeks at at least 90° F. in an amount effective to reduce fabric stains, the enzyme stabilizing system including at least one chelating agent and at least one nonionic surfactant, with no additional enzyme stabilizer; and an aqueous carrier.

Device for use in the wrapping of coins

Devices for use in the wrapping of coins comprising a tray and a coin holder or coin scoop. The tray is formed with receptacles for removably receiving the coin holder. There is a receptacle for each of various denominations of coins. At the forward end of each receptacle is a coin count abutment wall. The extent of the projection of the coin count abutment wall into its associated receptacle is related to a desired count of the coin denomination designated for the receptacle. The coin holder is indexed by the tray for a predetermined location within the receptacle. The filling of the trough of the coin holder with a column of coins of the denomination designated for the receptacle from a rear wall of the trough of the coin holder to the coin count abutment wall will cause the coin holder to carry a predetermined number of coins of the selected denomination.

Stable enzyme-containing aqueous laundry prespotting composition

A stable enzyme containing aqueous laundry prespotting composition is substantially free of conventional enzymatic stabilizers. The aqueous composition includes a chelating agent, a nonionic surfactant and a detergent enzyme.

Die sm-b/b1-antigene, das klonen der sm-b/b1-antigene und der nachweis von systemischem lupus erythematosus unter verwendung der sm b/b1-antigene.

To-fase-vaskemiddelblanding.

System and method for formulating compounds into personal care products

One or more methods for preparing a personal care product using HPP may be provided. The methods may include preparing one or more raw materials, including for example botanical or plant matter. The one or more raw materials may be infused into a substance using HPP, which may result in an infused substance. To make the final personal care product the infused substance may then be mixed with one or more additional ingredients and the personal care product may then be packaged. Finally, before shipping and distribution, the packaged personal care product may be processed using HPP, which may extend the shelf-life of the packaged product.

Völlig mikrohergestellte biosensoren und verfahren zur herstellung und verwendung

Bake-pan.

Polymers and polymeric assemblies for peptide and protein encaosulation and release, and methods thereof

The invention provides polymers and polymeric nanogels that stably encapsulate peptides and proteins, which are controllably released upon degradable of the nano-structures in response to specific microenvironment, and compositions and methods of preparation and use thereof.

Drafting-tool.

Immunological analogs for captan

Window component extrusion

Aqueous laundry prespotting composition

Furoxan-based compounds and uses thereof

Described herein are compounds of the formula (I), as well as pharmaceutical compositions comprising such compounds, and methods for using such compounds/pharmaceutical compositions for treating neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease, and multiple sclerosis (MS).

Intracellular delivery of therapeutic proteins designed to invade and autonomously lyse and methods of use thereof

Provided herein is a bacterial delivery platform that harnesses mechanisms unique to Salmonella to intracellularly deliver protein-based drugs.

Intracellular delivery of therapeutic proteins designed to invade and autonomously lyse and methods of use thereof

Provided herein is a bacterial delivery platform that harnesses mechanisms unique to Salmonella to intracellularly deliver protein-based drugs.

Intracellular delivery of therapeutic proteins designed to invade and autonomously lyse and methods of use thereof

Provided herein is a bacterial delivery platform that harnesses mechanisms unique to Salmonella to intracellularly deliver protein-based drugs.

Intracellular delivery of therapeutic proteins designed to invade and autonomously lyse and methods of use thereof

Provided herein is a bacterial delivery platform that harnesses mechanisms unique to Salmonella to intracellularly deliver protein-based drugs.

Intracellular delivery of therapeutic proteins designed to invade and autonomously lyse and methods of use thereof

Provided herein is a bacterial delivery platform that harnesses mechanisms unique to Salmonella to intracellularly deliver protein-based drugs.

Rostrikovac tlakove kapaliny s ukoncenim pro rychloupinaci hadicovou spojku

Hybrid tea rose plant named Devdorado

A new hybrid tea rose plant producing yellow flowers.

Hybrid tea rose plant named Devcico

A new hybrid tea rose plant producing pink flowers.

Hybrid tea rose plant named Devmomento

A new hybrid tea rose plant producing yellow flowers.

Hybrid tea rose plant named Devspilio

A new hybrid tea rose plant producing white flowers.

Hybrid tea rose plant named Devstar

A new hybrid tea rose plant producing white flowers.

Hybrid tea rose variety named `Devcal`

A hybrid tea rose variety producing white flowers.

Liquid storage tank especially for mechanical insulin dosers

Peptid-Synthese-Verfahren

Intracellular delivery of therapeutic proteins designed to invade and autonomously lyse and methods of use thereof

Provided herein is a bacterial delivery platform that harnesses mechanisms unique to Salmonella to intracellularly deliver protein-based drugs.

Hybrid tea rose plant named Devpajaro

A new hybrid tea rose plant producing red orange flowers.

Rozstřikovač tlakové kapaliny s ukončením pro rychloupínací hadicovou spojku

Podstatou řešení je těleso rozstřikovače sestavené z přívodní příruby, segmentů a koncové příruby, vzájemně spojených rozebíratelným způsobem v jeden celek, s možností snadné demontáže a montáže za účelem vyčištění funkčních částí od mechanických nečistot. Segmenty jsou ve tvaru klínu a na čele opatřené drážkami malého průřezu a tvaru podle potřebné hustoty a jemnosti proudu rozstříknuté kapaliny. Drážky zasahují vějířovitě do přívodního otvoru, procházejícího přívodní přírubou a segmenty. Počet použitých segmentů určuje velikost zavlažované plochy v závislosti na množství a tlaku přiváděné kapaliny.

Un polipeptido recombinante y su metodo de produccion.

SE AISLAN PROTEINAS SNRNP, POR CROMATOGRAFIA DE INMUNOAFINIDAD, UTILIZANDO ANTICUERPOS DE UNA MUESTRA DE SUERO DE UN SER VIVO AFECTADO POR LUPUS ERITEMATOSUS SITEMICO. LOS POLIPEPTIDOS SM-B Y/O SM-B'' SE AISLAN A PARTIR DEL COMPLEJO PROTEINICO SNRNP POR ELECTROFORESIS DE GELES Y ELECTROELUCION. LUEGO SE SECUENCIAN LOS AMINO TERMINALES DE LOS POLIPEPTIDOS SM-B Y/O SM-B'', Y SE SINTETIZAN LAS SONDAS DE DNA MARCADAS CON SECUENCIAS DE NUCLEOTIDOS COMPLEMENTARIAS CON LAS QUE CODIFICAN LA SECUENCIA DE AMINOACIDOS. UNA BIBLIOTECA DE CDNA HUMANO EN UN VECTOR DE CLONACION LAMBDA SE TRANSFIERE A FILTROS ADECUADOS TALES COMO FILTRO DE NITROCELULOSA. ESTOS FILTROS SON INVESTIGADOS POR HIBRIDACION CON SONDAS MARCADAS PARA IDENTIFICAR LOS CLONES DE CDNA EN LA BIBLIOTECA CON SECUENCIAS QUE IGUALAN A LAS DE LAS SONDAS MARCADAS. LUEGO SE SUBCLONA EL CDNA QUE CODIFICA LAS PROTEINAS DE SM-B Y/O SM-B''. LUEGO SE AISLAN LOS POLIPEPTIDOS DE SM-B Y/O SM-B'' POR CROMATOGRAFIA DE INMUNOAFINIDAD Y, SI SE DESEA ADEMAS,POR CROMATOGRAFIA HPLC. LUEGO SE HACE UN ENSAYO CON LOS POLIPEPTIDOS DE SM-B Y/O SM-B'' AISLADOS HACIENDO REACCIONAR DICHOS POLIPEPTIDOS CON UNA MUESTRA DE SUERO DE UN SER VIVO PARA DETERMINAR SI ESTE ESTA AFECTADO POR LUPUS ERITEMATOSUS SISTEMICO. EL ENSAYO TAMBIEN SE PUEDE HACER CON UNA MEZCLA DE LOS POLIPEPTIDOS DE SM-B Y/O SM-B'' AISLADOS Y UN POLIPEPTIDO DE SM-D AISLADO (AISLADO ESENCIALMENTE COMO SE DESCRIBIO ANTES). EL ENSAYO SE PUEDE LLEVAR A CABO CON INMUNOABSORBENTE LIGADO A ENZIMA, TAL COMO ANTICUERPOS DE IGG-IGM ANTIHUMANO UNIDOS COVALENTEMENTE A UN INDICADOR ENZIMATICO. LACTOPEROXIDASA FOSFATASA ALCALINA SON CADA UNA UN EJEMPLO DE UN INDICADOR ENZIMATICO PARA INDICAR, MEDIANTE UN COLOR CARACTERISTICO, UNA PERSONA AFECTADA.

Die sm-b/b1-antigene, das klonen der sm-b/b1antigene und der nachweis von systemischem lupus erythematosus unter verwendung der sm b/b1- antigene.

Die sm-b/b1-antigene, das klonen der sm-b/b1-antigene und der nachweis von systemischem lupus erythematosus unter verwendung der sm b/b1-antigene.

Floribunda rose plant named `Devrudi`

A floribunda rose plant variety producing single deep pink to light red flowers in clusters.

Floribunda rose plant named `Devsmooth`

A floribunda rose variety producing red flowers.

Orangefarbene bis rubinrote Dis persions Disazofarbstoffe

Grandiflora rose plant named Devunican

A new grandiflora rose plant producing yellow flowers.

Hybrid tea rose plant named Devcarlos

A new variety of hybrid tea rose plant producing yellow flowers.

Immunological analogs for captan

There is provided a standard for use in testing for captan in immunoassays. This standard has the structure THPD-(CH2)x-(R3)y-R1 wherein THPD is c^_i^_s^_-1,2,3,6-tetrahydrophthalimido, x is an integer from 1 to 10, R1 selected from the group consisting of -COOH, -NH¿2?, -NO2, -SH and -OH, R?3¿ is an aryl moiety and y is 0 or 1. Compounds of this general structure are known, they mimic the immunological reaction of captan and related compounds which are not stable in water and thus cannot be satisfactorily used as standards in testing for the presence and level of presence of captan and related compounds. There is also provided a method of carrying out such testing, utilizing such standards in which the standard (I) is coupled to a protein that is large enough to elicit an immune response in warm blooded animals, to yield compound (II). THPD-(CH¿2?)x-(R?3)¿y-R2-[-C*-]-[LP](II), wherein C** is a coupling agent capable of coupling a member of the group R1 to a protein, R2 is the residue remaining when R1 is coupled with coupling agent C**, C* is the residue remaining from coupling agent C** after coupling a member of the group R1 to a protein and LP is a protein of sufficient size to generate an antibody response in a warm blooded animal.

Liquid storage tank especially for mechanical insulin dosers

Television apparatus

Festphasen-Syntheseverfahren zur Herstellung von Peptidestern

Health built-on-trust (healthbot) a mobile health (mhealth) application

The invention is a web-based integrated mobile health m(Health) application that allows communication a patient, pharmacist, and physician in a community setting. This app places the patient at the center of healthcare. The application enables the pharmacist and the physician to monitor a patient's medication use with either a smartphone or computer.

Hybrid tea rose plant named Devfrago

A new variety of hybrid tea rose plant producing apricot flowers.

Installation de chauffage de locaux.

Manufacture of tantalum filaments for electric lamps

Krouzek proti samovysavani anevysavani mleka u dojnic

Kroužek proti samovysávání a vysávání mléka u dojnic

Účelem vynálezu je zamezení samovýsávání a vysávání mléka u dojnič při společném ustájení. Zavedením kroužku z plastu do mulce /nosní přepážky/ dojnice, způsobuje tento nasávání nežádoucího vzduchu, a tím znemožní nasávání mléka. Podstata vynálezu je kroužek, sestávající ze dvou polokruhových segmentů, vyznačený tím, že každý z polokruhových s‘egmentů je na jednom čele příčného řezu opatřen osazeným čepem a na druhém čele příčného řezu tvarovým otvorem pro vzájemné pevné osové spojení čepů s otvory obou segmentů. Segmenty jsou na vnější ploše opatřeny dvěma zářezy pro zachycení lisovací síly, potřebné k zatlačení čepu do otvoru. Kroužek je zhotoven ze zdravotně nezávadného plastu.

Foam specimen apparatus and method

A device for aiding in the preparation of very thin slices of foam sheet material that is to be examined under a microscope. The device has a clamp arrangement for holding a sample of foam sheet material. A screw feed arrangement permits the foam sheet material to be advanced past a planar surface where a very thin slice of foam material can be removed. A clamping arrangement keeps the foam sheet material in linear alignment at the location where the sample is severed. A detent arrangement permits a metered amount of foam sheet material to be advanced past the planar cutting surface by the screw feed arrangement. The method of preparing a foam sample by first severing the foam material while it is held by the apparatus, thus establishing a planar cut, then positioning the material for a second cut which is then made parallel to the first cut.

Small molecule inhibitors of Mcl-1 and uses thereof

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having benzoic acid structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.