DETECTING SENSOR FOR SENSING CELL WITH HIGH ELECTRON MOBILITY TRANSISTOR (S) AND RING RESONATOR (E)

SCHOTTKY SENSOR FOR DETECTING A COMPONENT OF EXHAUST GAS

DETECTING SENSOR FOR HIGH ELECTRON MOBILITY TRANSISTOR OF A SELECTIVE GASEOUS OR LIQUID COMPONENT

L'invention porte sur un procédé et un capteur de détection ou de mesure d'au moins un composant spécifique parmi plusieurs composants présents dans un mélange gazeux ou liquide par un capteur (1) comprenant au moins une cellule de captage à transistor à haute mobilité électronique comportant une source (2) et un drain (3) avec une grille (4) intercalée entre source (2) et drain (3), une tension étant appliquée entre source (2) et drain (3) et une intensité de courant dans la cellule de captage étant relevée. Il est procédé à un pilotage de la tension entre source (2) et drain (3) faisant varier l'intensité de courant, le pilotage de la tension se faisant selon un modèle de tension prédéterminé par expérience pour délivrer un profil d'intensité caractéristique dudit au moins un composant spécifique.

SCHOTTKY SENSOR DETECTING A CONSTITUENT OF AN EXHAUST GAS

SENSOR FOR DETECTING A COMPONENT IN A GAS

PROCESS AND APPARATUS ALLOWING AN ADAPTIVE ROUTING IN A SYSTEM DETELECOMMUNICATIONS BY SATELLITES

SYSTEM AND METHOD FOR TRANSMITTING DATA PACKETS

COOLING OF ELECTRICAL MOTOR WITH TUBE OF COOLING AND PLATES OR CUPS OF CONDUCTION

Le stator (12) d'une machine électrique refroidie par fluide, telle qu'un moteur, générateur ou ensemble moteur-générateur comprend un noyau de stator annulaire (10) comprenant des dents faisant saillie vers l'intérieur (18) et des rainures externes (20) dans une surface externe (24) du noyau alignées radialement sur les dents. Des enroulements électroconducteurs (16) sont montés sur les dents faisant saillie vers l'intérieur et un ensemble formant tube (28) pour réfrigérant comprend un tube (26) en serpentin. Le tube comprend des parties de tube s'étendant axialement reçues dans les rainures de noyau de stator externes et des spires terminales reliant entre elles les paires adjacentes des parties de tube s'étendant axialement. Les éléments de conduction de chaleur sont fixés aux spires terminales (32) du tube de refroidissement et un logement (38) entourant la surface externe du noyau de stator maintient les parties de tube s'étendant axialement dans les rainures externes.

CONNECTOR OF CROSSING EDGE OF CHART AND TOGETHER OF COMPONENTS

Un connecteur de bord de carte traversant a un corps isolant définissant une extrémité supérieure et une portion de fiche mâle s'étendant de manière transversale à partir de l'extrémité supérieure. La portion de fiche mâle a des dimensions circonférentielles extérieures de manière à s'étendre à travers un trou de montage dans un premier composant électronique, comme une carte à circuit imprimé. Une douille ouverte est définie dans une extrémité de la portion de fiche mâle opposée à l'extrémité supérieure et définit une première fente ayant de premières dimensions pour réception d'un premier bord de carte, et une seconde fente ayant de secondes dimensions pour réception d'un second bord de carte ayant des dimensions différentes du premier bord de carte. Un élément de connecteur sollicité par ressort est disposé dans la douille et est configuré pour faire contact électrique avec une borne de bord de l'un ou l'autre d'un premier et d'un second bord de carte inséré dans l'une ou l'autre des ...

DETECTING SENSOR FOR SENSING CELL WITH HIGH ELECTRON MOBILITY TRANSISTOR (S) AND RING RESONATOR (E)

L'invention porte sur un capteur sans fil de détection ou de mesure d'au moins un composant spécifique présent dans un mélange gazeux ou liquide, le capteur de gaz comprenant au moins une cellule de captage (1) à transistor à haute mobilité électronique comportant une source et un drain avec une grille intercalée entre source et drain. Ladite au moins une cellule de captage (1) à transistor à haute mobilité électronique est associée au moins un anneau résonateur fendu (2, 2a) d'au moins une fente (3, 3a) respective et connecté entre, d'une part, le drain et, d'autre part, la grille ou la source de ladite au moins une cellule de captage (1), le capteur détectant un changement d'intensité ou de fréquence de résonance en fonction de la présence et/ou de la concentration dudit au moins un composant spécifique dans le mélange gazeux ou liquide.

Compositions and methods of improving specificity in genomic engineering using rna-guided endonucleases

Disclosed herein are optimized guide RNAs (gRNAs) and methods of designing and using said optimized gRNAs that have increased target binding specificity and reduced off-target binding.

Skeletal myoblast progenitor cell lineage specification by crispr/cas9-based transcriptional activators

Disclosed herein are methods and systems for increasing expression of Pax7, methods of activating endogenous myogenic transcription factor Pax7 in a cell, methods of differentiating a stem cell into a skeletal muscle progenitor cell, as well as compositions and methods for treating a subject in need of regenerative muscle progenitor cells. The compositions and methods may include a Cas9-based transcriptional activator protein and at least one guide RNA (gRNA) targeting Pax7.

Treatment of obesity and its complications

Combination treatment of obesity and its complications with seladelpar or a salt thereof and a glucagon-like peptide-1 (GLP-1) receptor agonist.

Automated application composer with natural language processing

An application automatically composed using natural language processing. A natural language input comprising one or more application requirements is received via an interface. The natural language input is parsed to extract one or more chunks, each chunk representing one of the application requirements, and at least one of the chunks representing at least one of one or more main functionalities described by the application requirements. A coarse architecture logically arranging the main functionalities to satisfy the application requirements is inferred according to the chunks. Existing assets corresponding to the chunks are identified, each asset associated with at least one of the main functionalities. The identified assets are assembled according to the coarse architecture. The assembled assets are deployed as an application.

Alfalfa variety h0515a3140

The invention relates to the alfalfa variety designated H0515A3140. Provided by the invention are the seeds, plants and derivatives of the alfalfa variety H0515A3140. Also provided by the invention are tissue cultures of the alfalfa variety H0515A3140 and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing the alfalfa variety H0515A3140 with itself or another alfalfa variety and plants produced by such methods.

Genome engineering with type i crispr systems in eukaryotic cells

Disclosed herein are Type I Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) system related compositions and methods of using said Type I CRISPR/Cas system related compositions for altering gene expression and genome engineering. The invention relates to compositions comprising Type I CRISPR-Cas polypeptides and CRISPR array nucleic acids designed for genome modification in eukaryotic cells and for targeted killing of eukaryotic cells.

Hydrocarbon hydrogenation catalyst and process

Hydrodealkylation of C9+ aromatic compounds

A catalyst composition and a process for hydrodealkylating a C 9 + aromatic compound such as, for example, 1,2,4-trimethylbenzene to a C 6 to C 8 aromatic hydrocarbon such as a xylene are disclosed. The composition comprises an alumina, a metal oxide, a phosphorus oxide and optionally, an acid site modifier selected from the group consisting of silicon oxides, sulfur oxides, boron oxides, magnesium oxides, tin oxides, titanium oxides, zirconium oxides, molybdenum oxides, germanium oxides, indium oxides, lanthanum oxides, cesium oxides, and combinations of any two or more thereof. The process comprises contacting a fluid which comprises a C 9 + aromatic compound with the catalyst composition under a condition sufficient to effect the conversion of a C 9 + aromatic compound to a C 6 to C 8 aromatic hydrocarbon.

Hydrocarbon conversion

A hydrocarbon conversion process comprises: (1) contacting a hydrocarbon feed such as, for example, gasoline, with a catalyst under a sufficient condition to effect the conversion of the hydrocarbon to a product stream comprising aromatic hydrocarbons and olefins; (2) separating the product stream into a lights fraction comprising primarily hydrocarbons less than 6 carbon atoms per molecule, a middle fraction comprising C 6 -C 8 aromatic hydrocarbons and non-aromatic hydrocarbons, and a C 9 + fraction comprising aromatic compounds; (3) separating the C 6 -C 8 aromatic hydrocarbons from the middle fraction; and (4) separating hydrocarbons containing 5 or more carbons per molecule (C 5 + hydrocarbons) from the lights fraction. The C 5 + hydrocarbons can be combined with the hydrocarbon feed. The non-aromatic hydrocarbons can also be converted to olefins by a thermal cracking process. Furthermore, the middle fraction can also be obtained by reforming naphtha.

Sleeve style carton

A sleeve style closed end carton for a can matrix where the cans preferably are the type having necked in head and heel rims. The carton includes corner flaps that are wrapped around the corner cans of the matrix, the corner flaps, along with the top and bottom side wall corners, preferably being structured to make the tapered portion of each corner can's head and heel partially visible when the carton is viewed in top and bottom views, as well as side elevation view, thereby in effect eliminating the carton's corners.

Catalytic hydrogenation of unsaturated dinitriles

Unsaturated dinitriles are hydrogenated to saturated diamines using a rhodium catalyst on a silica support having a surface area larger than 275 m 2 /g, a pore volume of from about 1.0 to 1.5 mL/g and an average pore size of from about 100 to about 175 A. The supported rhodium catalyst is prepared by a method which includes the steps of contacting a silica support having the characteristics described above with a solution or dispersion of rhodium or a reducible compound of rhodium, and then subjecting the impregnated silica support to vacuum treatment.

Selective para-xylene production via methylation of toluene with methanol in the presence of modified HZSM-5 catalyst

We disclose a method for preparing a catalyst for converting toluene to xylenes. As an example, in one embodiment the method can include: (i) binding HZSM-5 to silica, to form silica-bound HZSM-5; (ii) silylating the silica-bound HZSM-5, to form silylated silica-bound HZSM-5; (iii) calcining the silylated silica-bound HZSM-5, to form calcined silylated silica-bound HZSM-5; (iv) first washing the calcined silylated silica-bound HZSM-5, to form washed calcined silylated silica-bound HZSM-5; (v) first drying the washed calcined silylated silica-bound HZSM-5, to form dried calcined silylated silica-bound HZSM-5; (vi) steaming the dried calcined silylated silica-bound HZSM-5, to form steamed calcined silylated silica-bound HZSM-5; (vii) treating the steamed calcined silylated silica-bound HZSM-5 with acid, to form acid-treated calcined silylated silica-bound HZSM-5; (viii) second washing the acid-treated calcined silylated silica-bound HZSM-5, to form washed acid-treated calcined silylated silica-bound HZSM-5; and (ix) second drying the washed acid-treated calcined silylated silica-bound HZSM-5, to form the silica-bound HZSM-5 catalyst.

Selective para-xylene production via methylation of toluene with methanol in the presence of modified HZSM-5 catalyst

We disclose a method for converting toluene to xylenes, comprising contacting toluene with methanol in the presence of a silica-bound HZSM-5 catalyst. As an example, in one embodiment the method can include: (i) first silylating HZSM-5, to form silylated HZSM-5; (ii) first calcining the silylated HZSM-5, to form calcined silylated HZSM-5; (iii) binding the calcined silylated HZSM-5 to silica, to form silica-bound calcined silylated HZSM-5; (iv) extruding the silica-bound calcined silylated HZSM-5, to form extruded silica-bound calcined silylated HZSM-5; (v) second calcining the extruded silica-bound calcined silylated HZSM-5, to form extruded silica-bound twice-calcined silylated HZSM-5; (vi) second silylating the extruded silica-bound twice-calcined silylated HZSM-5, to form extruded silica-bound twice-calcined twice-silylated HZSM-5; and (vii) third calcining the extruded silica-bound twice-calcined twice-silylated HZSM-5, to form the silica-bound HZSM-5 catalyst.

Selective para-xylene production via methylation of toluene with methanol in the presence of modified HZSM-5 catalyst

We disclose a method for converting toluene to xylenes, comprising contacting toluene with methanol in the presence of a silica-bound HZSM-5 catalyst. As an example, in one embodiment the method can include: (i) first silylating HZSM-5, to form silylated HZSM-5; (ii) first calcining the silylated HZSM-5, to form calcined silylated HZSM-5; (iii) binding the calcined silylated HZSM-5 to silica, to form silica-bound calcined silylated HZSM-5; (iv) extruding the silica-bound calcined silylated HZSM-5, to form extruded silica-bound calcined silylated HZSM-5; (v) second calcining the extruded silica-bound calcined silylated HZSM-5, to form extruded silica-bound twice-calcined silylated HZSM-5; (vi) second silylating the extruded silica-bound twice-calcined silylated HZSM-5, to form extruded silica-bound twice-calcined twice-silylated HZSM-5; and (vii) third calcining the extruded silica-bound twice-calcined twice-silylated HZSM-5, to form the silica-bound HZSM-5 catalyst.

Method of making an improved catalyst containing an acid-treated zeolite, a boron component, and a zinc component, a product from such method, and the use thereof in the conversion of hydrocarbons

An improved zeolite catalyst containing an acid-treated zeolite, a boron component and a zinc component manufactured by a novel method having certain process steps necessary for providing the improved zeolite catalyst. The process steps include a first steam treatment of an acid-treated zeolite, followed by incorporation of such zeolite with a boron component and a zinc component, followed by a second steam treatment. Processes are also disclosed for using the improved zeolite catalyst in the conversion of hydrocarbons, preferably non-aromatic hydrocarbons, to lower olefins (such as ethylene and propylene) and aromatic hydrocarbons (such as benzene, toluene, and xylene).

Recovery of inert hydrocarbon diluents used in preparation of catalysts

In a catalyst preparation process wherein effluent solvent or diluent is water washed to remove impurities and subsequently recycled to the process, the formation of solids upon mixing organic and aqueous phases is prevented by the admixture in appropriate proportions of effluent portions containing, e.g., an organoaluminum compound such as ethylaluminum sesquichloride and a transition metal tetrahalide such as titanium tetrachloride, respectively, then mixing with water, followed by optional neutralization of the acidic aqueous phase with a chemical base such as NH 4 OH.

Solvent recovery from solutions of organic aluminum compound

The hydrocarbon solvent contained in a solution of an organoaluminum compound is recovered by a process comprising contacting the solution with water at a volume ration of from about 3:1 to about 8:1. Preferably, the solvent is n-hexane, the organoaluminum compound is triethylaluminum sesquichloride, and the solution has been used in a process for preparing olefin polymerization catalysts.

Solid-fluid contacting apparatus

In a batch process in which fluid is contacted with solid particles in a vessel and withdrawn therefrom through a passageway, the passageway is provided with filtering means to prevent solid particles from escaping. The next batch of feed is introduced into the vessel through the same passageway causing displacement of the particles retained by the filtering means and carrying them back into the contacting zone of the vessel.

Isolation of 3-methyl-1-butene from a hydrocarbon stream

A process for recovering 3-methyl-1-butene from a hydrocarbon stream by treating the stream with sulfuric acid to remove compounds which form azeotropes with 3-methyl-1-butene and separating the remaining stream.

Catalyst composition and processes therefor and therewith

A catalyst composition and a process for hydrodealkylating a C 9 + aromatic compound such as, for example, 1,2,4-trimethylbenzene to a C 6 to C 8 aromatic hydrocarbon such as a xylene are disclosed. The composition comprises an alumina, a metal oxide, a phosphorus oxide and optionally, an acid site modifier selected from the group consisting of silicon oxides, sulfur oxides, boron oxides, magnesium oxides, tin oxides, titanium oxides, zirconium oxides, molybdenum oxides, germanium oxides, indium oxides, lanthanum oxides, cesium oxides, and combinations of any two or more thereof. The process comprises contacting a fluid which comprises a C 9 + aromatic compound with the catalyst composition under a condition sufficient to effect the conversion of a C 9 + aromatic compound to a C 6 to C 8 aromatic hydrocarbon.

Tubular joint seal

Polyurethanes made from hydroxyl-containing fatty acid amides

Polyurethanes, and rigid polyurethane foams in particular, are made using certain amides of modified fatty acids. The fatty acid groups are substituted hydroxymethyl, N-hydroxyalkyl aminoalkyl or hydroxy-substituted ester groups. The amide portion of the molecule contains hydroxyalkyl or other hydroxyl-substituted organic groups bonded to the amide nitrogen.

Anti-viral compounds

Anti-viral compounds

Anti-viral compounds

Trisubstituted heterocycles as replication inhibitors of hepatitis C virus HCV

Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Anti-viral compounds

本發明描述一種可有效抑制C型肝炎病毒(「HCV」)複製之化合物。本發明亦關於製備該等化合物之方法，包含該等化合物之組合物，及使用該等化合物來治療HCV感染之方法。

Anti-viral compounds to treat hcv infection.

Se describen compuestos efectivos para inhibir la replicación del Virus de Hepatitis C ("VHC"). Esta invención también se refiere a procedimientos para elaborar dichos compuestos, a composiciones que comprenden dichos compuestos, y a métodos para utilizar dichos compuestos para tratar infección por VHC.

Anti-viral compounds to treat hcv infection

Anti-viral compounds to treat hcv infection

Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Anti-viral compounds.

Anti-viral compounds to treat hcv infection hcv

Anti-viral compounds

Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Compound derived from ((4-terbutylphenyl) pyrrolidin-2,5-diyl) bis (4,1-phenylene) substituted, vhc replication inhibitor; pharmaceutical composition; Useful in the treatment of a vhc infection.

LA PRESENTE INVENCIÓN REIVINDICA EL COMPUESTO (2S,2'S)- 1,1 '-((2S,2'S)-2,2-(4,4-((2S,5S)- 1-(4-TERT-BULILFENIL)PIRROLIDIN-2,5-DIIL)BIS(4, 1 -FENILEN))BIS(AZANDIIL)BIS(OXOMETILEN) BIS(PIRROLIDIN-2, 1 -DIIL))BIS (3-METIL-I-OXOBUTAN-2,1-DIIL)DICARBAMATO DE DIMETILO ÚTIL PARA INHIBIR LA REPLICACIÓN DEL VIRUS DE LA HEPATITIS C (VHC). ESTA INVENCIÓN TAMBIÉN SE RELACIONA CON UNA COMPOSICIÓN FARMACÉUTICA QUE COMPRENDE DICHO COMPUESTO, ÚTIL PARA TRATAR INFECCIONES POR VHC" THIS INVENTION REIVINDICATES THE COMPOUND (2S, 2'S) - 1,1 '- ((2S, 2'S) -2,2- (4,4 - ((2S, 5S) - 1- (4-TERT-BULILFENIL) PIRROLIDIN -2,5-DIIL) BIS (4, 1-PHENYLENE)) BIS (AZANDIIL) BIS (OXOMETILEN) BIS (PIRROLIDIN-2, 1 -DIIL)) BIS (3-METIL-I-OXOBUTAN-2,1-DIIL ) DIMETHYL DICARBAMATE USEFUL TO INHIBIT THE REPLICATION OF HEPATITIS C VIRUS (HCV). THIS INVENTION IS ALSO RELATED TO A PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUND, USEFUL TO TREAT HCV INFECTIONS "

SUSPENSION VIRUS INHIBITIONS C

Περιγράφονται ενώσεις αποτελεσματικές στην αναστολή της αντιγραφής του ιού της Ηπατίτιδας C ("ΗCV"). Η παρούσα εφεύρεση αναφέρεται επίσης σε διεργασίες δημιουργίας αυτών των ενώσεων, σε συνθέσεις περιλαμβάνουσες αυτές τις ενώσεις και σε μεθόδους χρήσεως αυτών των ενώσεων για την αγωγή της μολύνσεως από ΗCV. Compounds effective in inhibiting hepatitis C virus replication ("HCV") are described. The present invention also relates to processes for the production of these compounds, to compositions comprising these compounds, and to methods of using these compounds for the treatment of HCV infection.

Heterocyclic compounds as inhibitors of hepatitis C virus (HCV)

Effective compounds for inhibiting hepatitis c virus ("HCV") replication

La presente invención se refiere al compuesto (2S,2'S)-1,1'-((2S,2'S)-2,2'-(4,4'-((2S,5S)-1-(4-tert-butilfenil)pirrolidin-2,5-diil)bis(4,1-fenilen))bis(azandiil)bis(oxometilen)bis(pirrolidin-2,1-diil))bis(3-metil-1-oxobutan-2,1-diil)dicarbamato de dimetilo y composicionfarmaceuticaque lo comprende Los compuestos de la presente invención son eficaces para inhibir la replicación del virus de la hepatitis C (“HCV”).

ANTIVIRAL COMPOUNDS

Compuestos eficaces para inhibir la replicación del virus de la hepatitis C ("HCV"). Esta invención también se relaciona con procesos de elaboración de tales compuestos, con composiciones que comprenden a dichos compuestos y con métodos de uso de dichos compuestos para tratar una infección por HCV.

Trisubstituted heterocycles as replication inhibitors of hepatitis c virus hcv hcv

(4-TERT-BUTYLPHENYL) PYRROLIDIN-2,5-DIPHENYL DERIVED AS HCV INHIBITORS

SE REFIERE A COMPUESTOS HETEROCICLOS DE FORMULA (I) DONDE X ES CARBOCICLO(C3-C12) O HETEROCICLO DE 3 A 12 MIEMBROS; L1 Y L2 SON CADA UNO UNA UNION, ALQUILENO(C1-C6), ALQUINILENO(C2-C6), ENTRE OTROS; L3 ES UNA UNION O Ls-K-Ls', EN DONDE K ES O, S, C(O), S(O)2, OS(O), ENTRE OTROS; Ls Y Ls' SON CADA UNO UNA UNION, ALQUILENO(C1-C6), ALQUENILENO(C2-C6) O ALQUINILENO(C2-C6); A Y B SON CADA UNO CARBOCICLO(C3-C12) O HETEROCICLO DE 3 A 12 MIEMBROS; D ES H, CARBOCICLO(C3-C12), HETEROCICLO DE 3 A 12, ENTRE OTROS; Y ES -LK-T-RD, ENTRE OTROS; Z ES -LK-E, ENTRE OTROS, EN DONDE T ES Ls, Ls-M-Ls', ENTRE OTROS, DONDE M ES C(O), OS(O)2, C(O)O, ENTRE OTROS; LK ES ALQUILENO(C1-C6), ALQUENILENO(C2-C6), ENTRE OTROS; RD ES H, HALOGENO, NITRO, OXO, CN, ENTRE OTROS; E ES CARBOCICLO(C3-C12) O HETEROCICLO DE 3 A 12 MIEMBROS. SON COMPUESTOS PREFERIDOS: ({(2R,5R)-1-[4-(METILSULFONIL)FENIL]PIRROLIDIN-2,5-DIIL}BIS{BENCEN-4,1-DIILCARBAMOIL(2S)PIRROLIDIN-2,1-DIIL[(2S)-3,3-DIMETIL-1-OXOBUTAN-1,2-DIIL]})BISCARBAMATO DE DIMETILO; ([(2S,5S)-1-{4-[6-(MORFOLIN-4-IL)PIRIDIN-3-IL]FENIL}PIRROLIDIN-2,5-DIIL]BIS{BENCEN-4,1-DIILCARBAMOIL(2S)PIRROLIDIN-2,1-DIIL[(2S)-3-METIL-1-OXOBUTAN-1,2-DIIL]})BISCARBAMATO DE DIMETILO; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA REPLICACION DEL VIRUS DE LA HEPATITIS C (VHC) SIENDO UTILES EN EL TRATAMIENTO DE LA INFECCION POR VHC

Hepatitis C virus inhibitors

Hepatitis c virus inhibitors

Trisubstituted heterocycles as replication inhibitors of hepatitis c virus hcv

Jedinjenje Formule I ili njegova farmaceutski prihvatljiva so,gde :svaki od A i B jei svaki je nezavisno po izboru supstituisan sajednim ili više RA;D je fenil i po izboru je supstituisan sa jednim ili više RA;L1, L2, i L3 su veze;X je 5- ili 6-člani heterocikl i po izboru supstituisan sa jednim ili više RA;Y i Z su nezavisnoRD je svaki nezavisno odabran od: (1) - O-C1-C6alkila, - O-C2-C6alkenila, - O-C2-C6alkinila, C1-C6alkila, C2-C6alkenila ili C2-C6alkitiila, od kojih je svaki nezavisno po izboru supstituisan, pri svakom pojavljivanju, jednim ili više supstituenata odabranih od halogena, hidroksi, merkapto, amino, karboksi, nitro, okso, fosfonoksi, fosfono, tiokso, formil, cijano, C3-C6karbocikl ili 3- do 6-člani heterocikl; ili (2) C3-C6karbocikl ili 3- do 6-člani heterocikl, gde je svaki nezavisno po izboru supstituisan, pri svakom pojavljivanju, jednim ili više supstituenata odabranih od halogena, hidroksi, merkapto, amino, karboksi, nitro, okso, fosfonoksi, fosfono, tiokso, formil, cijano, C1-C6alkil, C2-C6alkenil, C2-C6alkinil, C1-C6haloalkil, C2-C6haloalkenil ili C2-C6haloalkinil;LY' je svaki nezavisno odabran od C1-C6alkilen po izboru supstituisan halogenom, hidroksi, merkapto, amino, karboksi, fosfonoksi, - O-C1-C6alkil, -O-C2-C6alkenil,- O-C2-C6alkinil, ili 3- do 6-člani karbocikl ili heterocikl, gde je dati 3-do 6-člani karbocikl ili heterocikl po izboru supstituisan jednim ili višesupstituenata odabranih od halogena, hidroksi, merkapto, amino, karboksi, nitro, okso, fosfonoksi, fosfono, tiokso, formil, cijano, C1-C6alkil, C2-C6alkenil, C2-C6alkinil, C1-C6haloalkil, C2-C6haloalkenil ili C2-C6haloalkinil;RA je nezavisno, pri svakom pojavljivanju odabran od halogena, nitro, okso, fosfonoksi, fosfono, tiokso, cijano, ili -LS-RE, pri čemu dva susedna RA, zajedno sa atomima za koje su vezani i bilo koji atomi između atoma za koje su vezani, po izboru formiraju karbocikl ili heterocikl;RE je nezavisno, pri svakom pojavljivanju odabran od -O-RS, -S-RS, -C( ...

Anti-viral compounds

Heterocyclic compounds as inhibitors of hepatitis C virus (HCV)

Hepatitis C virus inhibitors

Anti-viral compounds

本發明係描述有效抑制C型肝炎病毒("HCV")複製之化合物。本發明亦關於製造此種化合物之方法，包含此種化合物之組合物，及使用此種化合物以治療HCV感染之方法。

Tri-substituted heterocycles AS INHIBITORS OF HEPATITIS C VIRUS (HCV) replication

Trisubstituted heterocycles as replication inhibitors of hepatitis C virus HCV

ANTIVIRAL COMPOUNDS

SE REFIERE A UN COMPUSTO DE FORMULA (I), O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, DONDE X ES LA FIGURA (II), Y ESTA OPCIONALMENTE SUSTITUIDO CON UNO O MAS RA DONDE X3 ES N, L1, L2, L3 SON ENLACES, A Y B SON CADA UNO, 1H-BENZIMIDAZOL, ENTRE OTROS; D ES LA FIGURA (III), DONDE RN ES HIDROGENO, ENTRE OTROS; J ES CARBOCICLO DE C3-C6, HETEROCICLO DE 3 A 6 MIEMBROS; RC' ES H, HALOGENO, HIDROXILO, ENTRE OTROS; RD' ES HALOGENO, , NITRO, OXO, FOSFONOXI, ENTRE OTRAS; R2 Y R5 TOMADOS JUNTOS CON LOS ATOMOS A LOS CUALES ESTAN UNIDOS, FORMAN PIRROLIDINA; R9 Y R12 TOMADOS JUNTOS CON LOS ATOMOS A LOS CUALES ESTAN UNIDOS, PIRROLIDINA QUE ESTAN OPCIONALMENTE SUSTITUIDO. SON COMPUESTO FAVORITOS ([(2S,3R,4R,5S)-1-(4-FLUOROFENIL)-3,4-DIMETOXIPIRROLIDIN-2,5-DIIL]BIS{BENCEN-4,1-DIILCARBAMOIL(2S)PIRROLIDIN-2,1-DIIL[(2S)-3,3-DIMETIL-1-OXOBUTAN-1,2-DIIL]})BISCARBAMATO DE DIMETILO, ([1-(4-TERT-BUTILFENIL)-1H-PIRROL-2,5-DIIL]BIS{BENCEN-4,1-DIILCARBAMOIL(2S)PIRROLIDIN-2,1-DIIL[(2S)-3-METIL-1-OXOBUTAN-1,2-DIIL]})BISCARBAMATO DE DIMETILO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA REPLICACION DEL VIRUS DE LA HEPATITIS C (VHC) REFERS TO A COMPUSE OF FORMULA (I), OR A PHARMACEUTICALLY ACCEPTABLE SALT OF THE SAME, WHERE X IS FIGURE (II), AND IS OPTIONALLY SUBSTITUTED WITH ONE OR MORE RA WHERE X3 IS N, L1, L2, L3 ARE LINKS, A AND B ARE EACH ONE, 1H-BENZIMIDAZOLE, AMONG OTHERS; D IS FIGURE (III), WHERE RN IS HYDROGEN, AMONG OTHERS; J IS CARBOCYCLE OF C3-C6, HETEROCYCLE OF 3 TO 6 MEMBERS; RC 'IS H, HALOGEN, HYDROXYL, AMONG OTHERS; RD 'IS HALOGEN,, NITRO, OXO, PHOSPHONOXY, AMONG OTHERS; R2 AND R5 TAKEN TOGETHER WITH THE ATOMS TO WHICH THEY ARE UNITED, FORM PYRROLIDINE; R9 AND R12 TAKEN TOGETHER WITH THE ATOMS TO WHICH THEY ARE ATTACHED, PYRROLIDINE WHICH ARE OPTIONALLY SUBSTITUTED. ARE FAVORITE COMPOUNDS ([(2S, 3R, 4R, 5S) -1- (4-FLUOROPHENYL) -3,4-DIMETOXYPYRROLIDIN-2,5-DIYL] BIS {BENCEN-4,1-DIILCARBAMOIL (2S) PIRROLIDIN-2 , 1- ...

Heterocyclic compounds as inhibitors of hepatitis c virus (hcv) (hcv)

Hepatitis c virus inhibitors

Anti-viral compounds

Anti-viral compounds

ANTIVIRAL COMPOUNDS

compuestos eficaces para inhibir la replicación del virus de la hepatitis C (HCV). Esta invención también se relaciona con procesos de elaboración de tales compuestos, con composiciones que comprenden a dichos compuestos y con métodos de uso de dichos compuestos para tratar una infección por HCV.

EFFECTIVE ANTIVIRAL COMPOUNDS TO INHIBIT THE REPLICATION OF HEPATITIS C ("HCV") VIRUSES AND C RELATED OMPOSITIONS

Compuestos eficaces para inhibir la replicación del virus de la hepatitis C (?HCV?). Esta invención también se relaciona con procesos de elaboración de tales compuestos, con composiciones que compre nden a dichos compuestos y con métodos de uso de dichos para tratar una infección por HCV

ANTIVIRAL COMPOUNDS

Compuestos eficaces para inhibir la replicación del virus de la hepatitis C ("HCV"). Esta invención también se relaciona con procesos de elaboración de tales compuestos, con composiciones que comprenden a dichos compuestos y con métodos de uso de dichos compuestos para tratar una infección por HCV.

ANTIVIRAL COMPOUNDS

Compuestos eficaces para inhibir la replicación del virus de la hepatitis C (“HCV”). Esta invención también se relaciona con procesos de elaboración de tales compuestos, con composiciones que comprenden a dichos compuestos y con métodos de uso de dichos compuestos para tratar una infección por HCV.

Anti-viral compounds

本發明係描述有效抑制C型肝炎病毒(“HCV”)複製之化合物。本發明亦關於製造此種化合物之方法，包含此種化合物之組合物，及使用此種化合物以治療HCV感染之方法。

Anti-viral compounds

Anti-viral compounds

本發明係描述有效抑制C型肝炎病毒(“HCV”)複製之化合物。本發明亦關於製造此種化合物之方法，包含此種化合物之組合物，及使用此種化合物以治療HCV感染之方法。

Anti-viral compounds

Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

System for syringe engagement to an injector

An injector system for injecting fluid includes a syringe and an injector. The syringe includes a body and a plunger movably disposed within the body. The plunger has at least one flexible leg extending toward the rearward end of the body. The injector has a housing with a front plate, a drive member at least partially disposed within the housing and operable to engage the plunger, and a syringe release assembly operable to release the syringe. The syringe assembly includes a syringe release gear that forms an enclosure for receiving the syringe when the syringe is fully seated within the housing and a plunger release tube surrounding at least a portion of the drive member. The plunger release tube has a first end rotationally engaged with the syringe release gear. Rotation of the syringe release assembly releases the at least one flexible leg from the drive member.

Antiviral compounds and uses thereof

This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Voltage fault detection and protection

A fault detection and protection circuit can include a comparing circuit (e.g., a comparator or a detector) that can be connected to a power line supplying power to an electronic device being tested. The comparing circuit can be configured to detect a fault in which the power line is shorted to ground. For example, the electronic device being tested may have a fault in which its power terminals are shorted to ground. Upon detection of such a fault, the comparing circuit activates one or more switches that shunt capacitors or other energy storage devices on the power line to ground. The comparing circuit may alternatively or in addition activate one or more switches that disconnect the power supply supplying power to the electronic device under test from probes contacting the electronic device.

Composite armour material

A composite armour material comprises an outer layer of steel material with a hardness between 47 ad 54 (Rockwell "C") and an inner layer of steel material with a hardness of between 28 and 36 (Rockwell "C") and a fracture toughness of 3.6 - 6.5 J/mm. The outer layer absorbs the ballistic impact of a projectile, and the inner layer absorbs the blast. The two layers are bonded together, preferably with a synthetic resin bonder such as a polysulphide based material or a polyurethane based material. A further layer of a composite of high tensile fibres together with a ductile polymer binder may be held in place adjacent to the inner layer, such that the material can stretch to trap any shrapnel which may penetrate the inner layer. A further outermost layer of applique material may also be attached, comprising two layers of mild steel sandwiching a layer of ceramic tiles.

Compositions and methods for epigenome editing

Disclosed herein are CRISPR/Cas9-based gene activation systems that include a fusion protein of a Cas9 protein and a protein having histone acetyltransferase activity, and methods of using said systems.

Hydrodealkylation process and catalyst composition

A catalyst composition and a process for hydrodealkylating a C 9 + aromatic compound such as, for example, 1,2,4-trimethylbenzene to a C 6 to C 8 aromatic hydrocarbon such as a xylene are disclosed. The composition comprises an alumina, a metal oxide, a phosphorus oxide and optionally, an acid site modifier selected from the group consisting of silicon oxides, sulfur oxides, boron oxides, magnesium oxides, tin oxides, titanium oxides, zirconium oxides, molybdenum oxides, germanium oxides, indium oxides, lanthanum oxides, cesium oxides, and combinations of any two or more thereof. The process comprises contacting a fluid which comprises a C 9 + aromatic compound with the catalyst composition under a condition sufficient to effect the conversion of a C 9 + aromatic compound to a C 6 to C 8 aromatic hydrocarbon.

Machine for tightening bale-ties, &c.

Short neck bottle carton

Potassium carbonate supports, catalysts and processes therewith

Abstract of the Disclosure Catalyst supports, catalysts, method for the preparation thereof, and dimerization processes therewith are provided. Catalyst supports consist essentially of potassium carbonate with a crush strength of at least 5 pounds and at least one carbonaceous compound. Catalysts consist essentially of at least one elemental alkali metal deposited on the novel catalyst supports. Optionally, the catalysts further consist essentially of at least one promoter selected from the group consisting of elemental copper, elemental cobalt, and finely divided stainless steel.

Slicing machine

Bearing

Treatment of nafld and nash

Tank latching arrangement for a cleaning apparatus

A cleaning apparatus for cleaning a surface in which cleaning solution is dispensed to the surface and substantially simultaneously extracted along with the dirt on the surface in a continuous operation is provided. In one aspect of the invention, the cleaning apparatus includes a housing and a recovery tank removably mounted to the housing. A solution tank for supplying a flow of cleaning solution to the surface is removably mounted to the housing. A suction nozzle is secured to the housing and is in fluid communication with the recovery tank. A suction source is in fluid communication with the suction nozzle for generating suction to draw dirt and liquid through the suction nozzle and into the recovery tank. A first latch is operatively connected to the solution tank to releasably latch the solution tank to the housing and a second latch is operatively connected to the recovery tank to releasably latch the recovery tank to said housing, wherein the second latch is in close proximity to the first latch.

Internal combustion engine

Dimerization Process and Catalysts Therefor

Catalyst supports, catalyst systems, methods for the preparation thereof, in dimerization processes therewith are provided. Catalyst supports are prepared from alkali metal carbonate, at least one low surface area silica-alumina, and a liquid. Catalyst systems comprised of at least one elemental alkali metal deposited on the catalyst support. Optionally, the catalyst system further comprises of at least one promoter.

Process for the production of alpha-methyl-alpha-phenyl-beta-ethylsuccinimide

Candida kefyr cytosine deaminase

A new cytosine deaminase gene and protein from Candida kefyr are provided. This protein has increased ability to convert the 5-fluorocytosine prodrug to its toxic form when compared against the E. coli enzyme.

Purification of cis-olefins

A method for purifying a cis-olefin formed by alkylating a sulfonate ester comprising mixing the reaction formed by alkylating a sulfonate ester with an acid solution, separating said acid solution, and mixing the resultant purification product with a C 1 -C 4 alcohol and optionally a base followed by separation and distillation, or passing said reaction mixture through a silica gel and collecting the cis-olefin fraction.

Method for heat treating steel piercer points

Rna-guided gene editing and gene regulation

Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based system related compositions and methods of using said CRISPR/Cas9-based system related compositions for altering gene expression and genome engineering. Also disclosed herein are compositions and methods of using said compositions for altering gene expression and genome engineering in muscle, such as skeletal muscle and cardiac muscle.

Tapping machine

Genome engineering with type i crispr systems in eukaryotic cells

Disclosed herein are Type I Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) system related compositions and methods of using said Type I CRISPR/Cas system related compositions for altering gene expression and genome engineering. The invention relates to compositions comprising Type I CRISPR-Cas polypeptides and CRISPR array nucleic acids designed for genome modification in eukaryotic cells and for targeted killing of eukaryotic cells.

Anthracnose Resistant Alfalfa Plants

The present disclosure provides alfalfa plants exhibiting broad spectrum resistance to Race 1, Race 2, and Race 5 anthracnose. Such plants may comprise novel introgressed genomic regions associated with disease resistance from Race 1, Race 2, and Race 5 anthracnose. In certain aspects, compositions, including novel polymorphic markers and methods for producing, breeding, identifying, and selecting plants or germplasm with a disease resistance phenotype are provided. Also provided are alfalfa varieties designated as C0416C4164 and H0415C4114. Provided by the invention are the seeds, plants and derivatives of alfalfa varieties C0416C4164 and H0415C4114. Also provided by the invention are tissue cultures of alfalfa varieties C0416C4164 and H0415C4114, and the plants regenerated therefrom. Still further provided by the invention are methods for producing alfalfa plants by crossing alfalfa variety C0416C4164 or H0415C4114 with itself or another alfalfa variety and plants produced by such methods.

Rock-drill.

Disk drive demodulating a spiral track by finding a maximum correlation between a spiral track crossing signal and a time-shifted nominal spiral track crossing signal

A disk drive is disclosed comprising a disk including a plurality of spiral tracks, wherein each spiral track comprises a high frequency signal interrupted by a sync mark at a sync mark interval, and a head actuated over the disk. The spiral tracks are demodulated by reading a spiral track to generate a spiral track crossing signal g(x n ), where x n is a time in a demodulation window, and determining a position error signal (PES) by determining a time-shift L that maximizes a correlation between g(x n ) and a function that estimates a nominal spiral track crossing signal having the time-shift of L.

Compositions and methods for modulating expression of methyl-cpg binding protein 2 (mecp2)

Provided in some aspects are compositions, such as DNA-targeting systems, fusion proteins, guide RNAs (gRNAs), and pluralities and combinations thereof, that bind to or target a methyl-CpG-binding protein 2 (MeCP2) locus. In particular, the present disclosure relates to the modulation of expression of the MeCP2 gene. In some aspects, also provided are polynucleotides, vectors, cells and pluralities and combinations thereof, that encode or comprise the DNA-targeting systems, fusion proteins, gRNAs or pluralities or combinations thereof, and methods and uses related to the provided compositions, for example, in modulating the expression of MeCP2, and/or in the treatment or therapy of diseases or disorders that involve the activity, function or expression of MeCP2, such as Rett syndrome.

Key reader and identifier system

A strictly mechanical key is used both as an informationcarrying medium and as a device for mechanically unlocking a lock in a conventional manner. The information stored on the mechanical key is read at an independent station prior to use in the mechanical lock. The intelligence imparted to the station is of significance in permitting or not permitting the functioning of the lock.

Vehicle wheel

Method of expanding tester drive and measurement capability

Compositions and methods of improving specificity in genomic engineering using rna-guided endonucleases

Disclosed herein are optimized guide RNAs (gRNAs) and methods of designing and using said optimized gRNAs that have increased target binding specificity and reduced off-target binding.

Anti-infective agents and uses thereof

This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Solderless electrical connector

Fog reduction in silver halide emulsions with 3-mercaptobenzoic acid

Rocker stool

Expression of herbicide metobolizing cytochromes p450

DNA sequences encoding herbicide metabolizing cytochrome P450 enzymes and iron-sulfur proteins that donate electrons to these enzymes, were introduced into plants and microorganisms rendering them able to produce the encoded gene products and to metabolize herbicides.

Catalyst and process for dehydrating 2-alcohols

Abstract of the Disclosure Novel catalysts are disclosed for the selective dehydration of 2-alcohols to .alpha.-olefins. In one case, the catalyst comprises at least one catalytic metal oxide on a low surface area aluminum oxide-containing support. In another case, the catalyst comprises a mixture of thorium oxide and cerium oxide on a base treated aluminum oxide containing support. There is also disclosed a novel process for obtaining high purity 4-methyl-1-pentene involving the dehydration of 4-methyl-2-pentanol followed by disproportionation with ethylene.

Cerium regeneration aid for ruthenium hydrogenation catalyst

In a ruthenium hydrogenation catalyst cerium moderates loss in catalytic activity and the physical degradation of the catalyst. In one embodiment, upon repeated regenerations during the catalytic hydrogenation of branched chain olefinically unsaturated aliphatic dinitriles, a ruthenium-cerium/Al 2 O 3 catalyst maintained a catalytic activity at higher levels through a series of hydrogenations and regenerations than did a catalyst containing only ruthenium.

Composite material for vehicle armor plating comprises harder, outer, ballistic impact resistant and inner, explosion resistant steel layers bonded with polymer resin

Composite material for armor plating comprises a ballistic impact resistant layer of steel of Rockwell C hardness 47-54 adhered to an inner explosion resistant steel layer of breaking toughness 3.6-6.5 J/mm and Rockwell C hardness 28-36.