Temporary expanding integrated monitoring network

A system for monitoring an industrial process and taking action based on the results of process monitoring. Actions taken may include process control, paging, voicemail, and input for e-enterprise systems. The system includes an input module for receiving a plurality of parameters from a process for manufacture of a substance or object. The system also includes a library module. The library module includes a plurality of computer aided processes. Any one of the computer aided processes is capable of using each of the plurality of parameters to compare at least two of the plurality of parameters against a training set of parameters. The training set of parameters is generally predetermined. The computer aided process is also capable of determining if the at least two of the plurality of parameters are within a predetermined range of the training set of parameters. Additionally, the system includes an output module for outputting a result based upon the training set and the plurality of parameters.

Interactive remote disease monitoring and management system

A system that requests clinical data from a patient and then provides the clinical data wirelessly to be reviewed or analyzed with a certified medical algorithm and/or decision tree. The certified algorithm and/or decision tree can provide a summary of the data, indication of severity, “smart” decision or intervention protocol to a nurse, doctor, and the like. In addition, the system with the certified algorithm and/or decision tree can provide the summary of the data, indication of severity, “smart” decision or intervention protocol to the nurse, doctor, and the like within a short time frame, e.g. within 5 minutes from the data being provided by the patient. The certified decision and/or protocol can be agreed to or changed by an individual, e.g. a doctor, which can then be forwarded or sent back to the patient. If the patient doesn't respond to the certified decision within a short time frame, e.g. within 3 minutes from the data being provided to the patient, then a series of triggers can take place, e.g., a text message to a caregiver and the like.

Shaped capacitive touch sensor, devices, and methods of use

Touch sensors and associated systems and methods are disclosed. The amount of skin of a user's finger that touches the touch sensor changes in relation to the intensity or pressure applied by the finger. A variable control signal is generated proportional to the pressure applied to the touch sensor.

Use of inhibitors of binding between a par-1 receptor and its ligands for the treatment of glioma

The present invention relates to a method of treating glioma in a subject. The method comprises selecting a subject having a glioma, providing an inhibitor of binding between a PAR-1 receptor and a ligand of the PAR-1 receptor, and administering the inhibitor to the selected subject under conditions effective to treat the glioma and/or prevent spread of tumor cells. Methods for inhibiting proliferation of glioma cells and/or precursors thereof and a method of screening for compounds suitable for treating glioma in subjects are also disclosed.

System and Method for Connecting a Compression-Type Coupling to a Coated Conduit

A tool for removing a coating from an end of a coated conduit comprising a metallic conduit having an outer diameter and a polymeric material applied over the outer diameter thereof is provided. The tool comprises: a guide member having an outer diameter sized to fit within an internal diameter of the metallic conduit; and a cylindrical cutting member having a substantially closed first end rotatably connected to an arbor, a substantially open second end, and a plurality of teeth elements. The cylindrical cutting member has an inner diameter that is substantially equal to the outer diameter of the metallic conduit such that when the cylindrical cutting member is rotated, the teeth elements remove the polymeric material from the outer diameter of the metallic conduit.

Traction Studs And Outsoles

A traction stud comprises: a carrier comprising a post, a hollow defined by the post that opens at a distal end of the post, and a multi-pronged flange at a proximal end of the post; and a tip bonded in the hollow and extending past the distal end of the post. The carrier may be metal and/or the tip is ceramic. The multi-pronged flange may comprise two or more prongs, each prong having a first face, a second face, a thickness, and one or more holes extending from the first face to the second face, wherein the first and second faces are substantially perpendicular to the post. Outsoles comprise the traction studs and boots and/or overshoes comprise the outsoles. The traction studs are securely retained by polymeric material of the outsoles. The studs penetrate and/or grip slippery surfaces such as ice and packed snow.

Disrupting tumor tissues by targeting fibroblast activation protein (fap)

The present invention relates to compositions and methods comprising a chimeric antigen receptor (CAR) capable of binding fibroblast activation protein (FAP) for use in treating diseases, disorders or conditions associated with the expression of FAP on canine, mouse, or human tumor-associated cells.

Cell-type selective immunoprotection of cells

The present disclosure is directed to preparation of one or more cells, wherein cells of the preparation are modified to conditionally express (i) increased levels of one or more immune checkpoint proteins as compared to corresponding wild-type cells, (ii) reduced levels of one or more HLA-I proteins as compared to corresponding wild-type cells, or a combination of (i) and (ii). The present disclosure is further directed to methods and constructs for producing the cell preparations as well as methods of administering the cell preparation to a subject in need thereof.

Carton with Removable Lid

A carton with a removable lid, the carton may include a floor panel; a plurality of side panels extending about a periphery of the bottom panel. The one or more of the side panels may include one or more tabs extending from an upper edge thereof. The carton may further include foldable corner gussets extending between adjacent side panels. The bottom panel, side panels, and foldable corner gussets may be configurable to form a compartment region; and a removable lid. The removable lid may include a lid panel and one or more slots formed in the lid panel, wherein the lid panel may be configured to cover the compartment region, and wherein the one or more slots may be sized, shaped, and positioned such that when the removable lid is installed atop the compartment region, the one or more tabs align with the one or more slots and are received therethrough.

Network device measurements employing white boxes

A system for network device measurements may use a white box to perform measurements that may help determine the likelihood of network anomalies, such as microbursts.

Prophylactic Compositions for Management of Microbial Infections in Patients with Brain Injury

The present disclosure pertains to antimicrobial compositions for intravenous administration to patients who have experienced a serious brain trauma, to reduce the risk of occurrence of post-trauma microbial infections. The antimicrobial compositions comprise an α-galacytosylceramide compound and one or more excipients. The present disclosure also pertains to the use of α-galacytosylceramide compounds for the manufacture of antimicrobial medicaments for intravenous administration to patients with serious brain traumas. The present disclosure also pertains to methods for the prophylactic use of the antimicrobial compositions to reduce the risks of occurrence of post-trauma microbial infections.

High melt strength polypropylene and process of preparation thereof

A high melt strength resin composition includes at least a) non-functionalized polypropylene, b) at least one acrylate such as zinc diacrylate, calcium diacrylate or aluminum triacrylate in a total amount of from 0.1 to 5% by weight based on the weight of non-functionalized polypropylene, and c) at least one acid neutralizer in a total amount of from 0.005 to 5% by weight based on the total weight of the at least one acrylate. The resin composition is compounded at a processing temperature between 185° C. and 260° C. to obtain the high melt strength polypropylene.

Removable ic package stiffener

A stiffener, an IC package and methods of fabrication of an IC package including a removable stiffener are shown. A removable stiffener for use with an integrated circuit (IC), including a plurality of adhesive portions disposed between a surface of the stiffener and a surface of a substrate of the IC is shown. Such a removable stiffener including at least one removal tab is shown. An IC package including a removable stiffener including a plurality of adhesive portions disposed between a surface of the stiffener and a surface of a substrate of the IC is shown. Methods of fabrication of an IC package including a removable stiffener are shown.

Compact liquid crystal beam steering devices including multiple polarization gratings

Systems, methods, and apparatus are disclosed for attenuating an incident polarized light beam using a plurality of LCPGs and one or more switchable liquid crystal layers. When four LCPGs are used, a spacing between first and second LCPGs can be equal to a spacing between third and fourth LCPGs. Pi and FCL cells can also be used in place of more traditional LC switches. Switching of the LC switch can be imparted via an AC bias.

Crystalline salts and polymorphs of a p2x3 antagonist

Provided are novel salts and polymorphs of 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzenesulfonamide, which are potentially useful for modulating a condition mediated by a P2X3 or P2X2/3 receptor. Also provided are pharmaceutical formulations and methods of administration and dosing of these salts and polymorphs to subjects in need thereof.

Calibration electrode

A calibration electrode for calibrating a reference system of an electrochemical sensor, such as a potentiometric sensor or an ion selective electrode. The calibration electrode has an active surface comprising redox functionalities. The redox functionalities set the pH of a reference solution proximal to the calibration electrode. A voltammetric signal is applied to the calibration electrode to produce a response that is determined by the set pH. The response of the calibration electrode to the voltammetric signal is used to calibrate/adjust a reference potential produced by a reference electrode of the reference system of the electrochemical sensor. This calibration corrects the detrimental effect of reference electrode drift.

Induced pluripotent cell-derived oligodendrocyte progenitor cells for the treatment of myelin disorders

The present invention relates to preparations of induced pluripotent cell-derived oligodendrocyte progenitor cells, and methods of making, isolating, and using these preparations.

Internet of things resource optimization

Approaches presented herein enable optimization of a plurality of resources connected within an Internet of Things (IoT) network. More specifically, usage of a first and a second resource of the plurality of resources connected within the IoT network is tracked. This usage comprises a task and a time at which the task is performed for each of the two resources. An anticipated task at an anticipated time based on the tracked usage of the first resource is identified. An anticipated capacity at substantially the same anticipated time is also identified on the second resource based on the tracked usage of the second resource. Excess capacity is generated on the first resource by transferring the anticipated first task to the second resource for the anticipated time. The excess capacity is designated for use by an arm's-length party. A load from the arm's-length party is then assigned to the excess capacity.

Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation

The present invention provides a process for the preparation of enantiomerically enriched, deuterated secondary alcohols of Formula 1-A by employing ketoreductases or carbonyl reductases without reducing deuterium incorporation.

Use of comb-branched copolymers in gypsum compositions comprising comb-branched copolymers

A gypsum composition suitable for use in the manufacture of construction materials is provided. The gypsum composition includes gypsum, water, and a dispersant formulation comprising an acrylic/polyether comb-branched copolymer. A method of making a gypsum composition is also provided. The method includes mixing together, in any combination, gypsum, water, and a dispersant formulation comprising an acrylic/polyether comb-branched copolymer. A wallboard is provided including two sheets of board paper, and a gypsum core between the sheets of board paper.

Polyolefin compositions

The present invention relates to polyolefin compositions that incorporate an acrylic/polyether comb-branched copolymer, articles made from the compositions, such as polyolefin films and polyolefin fibers, and methods for making the compositions and the articles.

Low pressure drop,high surface area ammonia oxidation catalyst and catalyst for production of hydrocyanic acid

Handheld sensing apparatus

A vapor sensing device that is sufficiently small and lightweight to be handheld, and also modular so as to allow the device to be conveniently adapted for use in sensing the presence and concentration of a wide variety of specified vapors. The device provides these benefits using a sensor module that incorporates a sample chamber and a plurality of sensors, located on a chip releasably carried within or adjacent to the sample chamber. Optionally, the sensor module can be configured to be releasably plugged into a receptacle formed in the device. Vapors are directed to pass through the sample chamber, whereupon the sensors provide a distinct combination of electrical signals in response to each. The sensors of the sensor module can take the form of chemically sensitive resistors having resistances that vary according to the identity and concentration of an adjacent vapor. These chemically sensitive resistors can each be connected in series with a reference resistor, between a reference voltage and ground, such that an analog signal is established for each chemically sensitive resistor. The resulting analog signals are supplied to an analog-to-digital converter, to produce corresponding digital signals. These digital signals are appropriately analyzed for vapor identification.

Apparatus for flipping and aligning a dough sheet

A single continuous dough sheet is conveyed by a conveyor up an incline to a dough tension and drive system. In the system, the dough sheet passes around a lower drive roller, around an intermediate drive roller, and around an upper drive roller. The dough sheet extends at a downward angle to an idler roller which directs the dough sheet generally vertically downward in a flat condition. A wishbone pushing element having a rounded V-shape forms the first face of the dough sheet into a generally V-shape having two wings. The wings of the V-shape are then guided by an aligning element such as laterally spaced rollers which roll on the opposite face of the wings to form a folded, two-ply continuous dough sheet. The angular relationship of the legs of the pushing element, the lateral spacing of the rollers of the aligning element and the three dimensional positioning of the pushing element and the aligning element can be adjusted to insure that the free edges in the folded continuous dough sheet are aligned relative to each other.

Heterogenous socket contact for electrical and mechanical performance scaling in a microelectronic package

A microelectronic socket structure and a method of forming the same. The socket structure comprises: a socket structure housing defining a cavity therein; and an interconnection structure including: a contact element disposed at least in part within the cavity, and configured to be electrically coupled to a corresponding microelectronic package, the contact element corresponding to one of a signal contact element or a ground contact element; and a conductive structure disposed at least in part within the cavity, electrically coupled to the contact element, and having an outer contour that is non-conformal with respect to an outer contour of the contact element.

Apparatus and methods for flipping and aligning a dough sheet

A single continuous dough sheet (12) is conveyed by a conveyor (20) up an incline to a dough tension and drive system (38). In the system (38), the dough sheet (12) passes around a lower drive roller (40), around an intermediate drive roller (42), and around an upper drive roller (44). The dough sheet (12) extends at a downward angle to an idler roller (80) which directs the dough sheet (12) generally vertically downward in a flat condition. A whishbone pushing element (82) having a rounded V-shape forms the first face of the dough sheet (12) into a generally V-shape having two wings. The wings of the V-shape are then guided by an aligning element (96) such as laterally spaced rollers (98, 100) which roll on the opposite face of the wings to form a folded, two-ply continuous dough sheet (14). The angular relationship of the legs (84, 86) of the pushing element (82), the lateral spacing of the rollers (98, 100) of the aligning element (96) and the three dimensional positioning of the pushing element (82) and the aligning element (96) can be adjusted to insure that the free edges in the folded continuous dough sheet (14) are aligned relative to each other.

Dispensing assembly with interchangeable cartridge pumps

This invention describes a cartridge pump and dispensing assembly for applications where cartridges containing liquid reagents are interchanged often. The cartridge pump comprises a reagent reservoir which directly empties into a metering chamber. A valve is at each end of the metering chamber. The two valves are aligned in the same direction so as to allow unidirectional liquid flow. The metering chamber is made of a compressible material, such as flexible tubing, so that when an external compression is applied to the chamber, the liquid contained therein is forcibly expelled. As the compression is removed, the metering chamber resumes its former shape and draws liquid into the chamber from the reagent reservoir. A dispensing assembly with electromechanical actuators for compression of the metering chamber and a means for sensing the amount of liquid contained within the reagent reservoir are also shown.

Dispensing assembly with interchangeable cartridge pumps

This invention describes a cartridge pump and dispensing assembly for applications where cartridges containing liquid reagents are interchanged often. The cartridge pump comprises a reagent reservoir which directly empties into a metering chamber. A valve is at each end of the metering chamber. The two valves are aligned in the same direction so as to allow unidirectional liquid flow. The metering chamber is made of a compressible material, such as flexible tubing, so that when an external compression is applied to the chamber, the liquid contained therein is forcibly expelled. As the compression is removed, the metering chamber resumes its former shape and draws liquid into the chamber from the reagent reservoir. A dispensing assembly with electromechanical actuators for compression of the metering chamber and a means for sensing the amount of liquid contained within the reagent reservoir are also shown.

Moving platform slide stainer with heating elements

This invention describes a cartridge pump and dispensing assembly for applications where cartridges containing liquid reagents are interchanged often. The cartridge pump has a reagent reservoir which directly empties into a metering chamber. A valve is at each end of the metering chamber. The two valves are aligned in the same direction so as to allow unidirectional liquid flow. The metering chamber is made of a compressible material, such as flexible tubing, so that when an external compression is applied to the chamber, the liquid contained therein is forcibly expelled. As the compression is removed, the metering chamber resumes its former shape and draws liquid into the chamber from the reagent reservoir. A dispensing assembly with electromechanical actuators for compression of the metering chamber and a sensor for sensing the amount of liquid contained within the reagent reservoir are also shown.

Automated slide stainer with slide housing

This invention describes a cartridge pump and dispensing assembly for applications where cartridges containing liquid reagents are interchanged often. The cartridge pump has a reagent reservoir which directly empties into a metering chamber. A valve is at each end of the metering chamber. The two valves are aligned in the same direction so as to allow unidirectional liquid flow. The metering chamber is made of a compressible material, such as flexible tubing, so that when an external compression is applied to the chamber, the liquid contained therein is forcibly expelled. As the compression is removed, the metering chamber resumes its former shape and draws liquid into the chamber from the reagent reservoir. A dispensing assembly with electromechanical actuators for compression of the metering chamber and a sensor for sensing the amount of liquid contained within the reagent reservoir are also shown.

Random access slide stainer with independent slide heating regulation

An automated slide stainer with slides mounted in a horizontal position on a rotary carousel. Reagents and rinse liquids are automatically dispensed onto tissue sections or cells mounted on slides for the purpose of performing chemical or immunohistochemical stains. The rinse liquids are removed by an aspiration head connected to a source of vacuum. Individual slides or groups of slides are supported on flat heating stations for heating to individual temperatures. Temperature control electronics on the carousel are controlled by a user interface off of the carousel.

Random access slide stainer with independent slide heating regulation

An automated slide stainer with slides mounted in a horizontal position on a rotary carousel. Reagents and rinse liquids are automatically dispensed onto tissue sections or cells mounted on slides for the purpose of performing chemical or immunohistochemical stains. The rinse liquids are removed by an aspiration head connected to a source of vacuum. Individual slides or groups of slides are supported on flat heating stations for heating to individual temperatures. Temperature control electronics on the carousel are controlled by a user interface off of the carousel.

Smart device facilitating computer network interaction

レーザーダイオード駆動チップ

(57)【要約】 【課題】 レーザーダイオード駆動チップによって発生 させられたレーザーダイオード駆動電流におけるリンギ ングを解消する。 【解決手段】 レーザーダイオード駆動チップ１４は電 圧受端ノードＶ DD と出力ノードＯとチップグラウンドＧ を有し、電圧受端ノードＶ DD とチップグラウンドＧは第 １の抵抗器Ｒ 4 と第１のキャパシターＣ 10 を介して互い に直列に接続され、出力ノードＯとチップグラウンドＧ は第２の抵抗器Ｒ 5 と第２のキャパシターＣ 11 を介して 互いに直列に接続され、レーザーダイオード駆動チップ １４、第１の抵抗器Ｒ 4 、第１のキャパシターｃ 10 、第 ２の抵抗器Ｒ 5 、および、第２のキャパシターＣ 11 が、 レーザーダイオード駆動チップ１４によって発生させら れた電流のリンギングを実質的に減少させるように構成 されて配置されている。

Anti-ssx-2 t cell receptor and related material and method of use

【課題】癌患者への腫瘍反応性Ｔ細胞の移植において、改良された免疫学的組成物及び方法の提供。 【解決手段】滑膜肉腫Ｘブレイクポイント（ＳＳＸ）−２に対し抗原特異性を有する、単離又は精製されたＴ細胞受容体（ＴＣＲ）、関連ポリペプチド及びタンパク質、並びに関連核酸、組換え発現ベクター、ホスト細胞、及び細胞集団。該ＴＣＲに関連する、抗体又はその抗原結合部位、及び医薬組成物。ホストにおける癌の存在を検出する方法、及びホストにおける癌を治療する又は予防する方法。 【選択図】なし

Multiple sensing system and device

The present invention provides a distributed sensing system in a networked environment for identifying an analyte, including a first sensor array connected to the network comprising sensors capable of producing a first response in the presence of a chemical stimulus; a second sensor array connected to the network comprising sensors capable of producing a second response in the presence of a physical stimulus; and a computer comprising a resident algorithm. The algorithm indicates or selects the most relevant sensor in the network to identify the analyte. The sensors can be separated over large spatial areas, wherein the sensor arrays are networked. Suitable networks include a computer local area network, an intranet or the Internet.

Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder

The present application relates to a non-human mammal model of a human neurodegenerative disorder, methods of producing the non-human mammal model, and methods of using the non-human mammal model to identify agents suitable for treating a neurodegenerative disorder. The present application also relates to methods of treating neurodegenerative disorders and restoring normal brain interstitial potassium levels.

Methods of treating schizophrenia and other neuropsychiatric disorders

The present disclosure is directed to methods of restoring glial cell K+ uptake in a subject. This method involves selecting a subject having impaired glial cell K+ uptake, and administering, to the selected subject, a RE1 -Silencing Transcription factor (REST) inhibitor under conditions effective to restore glial cell K+ uptake. Subjects having impaired glial cell K+ uptake include those at risk of having or having a neuropsychiatric disease or disorder.

Methods of treating or inhibiting onset of huntington's disease

The disclosure herein relates generally to a method of treating or inhibiting onset of Huntington's disease. This method involves selecting a subject having or at risk of having Huntington's disease and administering to the subject one or modulators of one or more genes as described herein, or proteins encoded therefrom, under conditions effective to treat or inhibit onset of Huntington's disease in the subject.

Methods of treating schizophrenia and other neuropsychiatric disorders

The present disclosure relates to methods of restoring K+ uptake by glial cells in a subject. These methods involve administering, to the subject, a SMAD4 inhibitor under conditions effective to restore K+ uptake by said glial cells. The present disclosure is also directed to methods of treating or inhibiting the onset of a neuropsychiatric disorder in a subject. These methods involve administering, to a subject in need thereof, a SMAD4 inhibitor under conditions effective to treat or inhibit the onset of the neuropsychiatric disorder in the subject.

Gene networks that mediate remyelination of the human brain

Induced pluripotent cell-derived oligodendrocyte progenitor cells for the treatment of myelin disorders

The present invention relates to preparations of induced pluripotent cell-derived oligodendrocyte progenitor cells, and methods of making, isolating, and using these preparations.

Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder

The present application relates to a non-human mammal model of a human neurodegenerative disorder, methods of producing the non-human mammal model, and methods of using the non-human mammal model to identify agents suitable for treating a neurodegenerative disorder. The present application also relates to methods of treating neurodegenerative disorders and restoring normal brain interstitial potassium levels.

Dispensing assembly with interchangeable cartridge pumps

This invention describes a cartridge pump and dispensing assembly for applications where cartridges containing liquid reagents are interchanged often. The cartridge pump comprises a reagent reservoir which directly empties into a metering chamber. A valve is at each end of the metering chamber. The two valves are aligned in the same direction so as to allow unidirectional liquid flow. The metering chamber is made of a compressible material, such as flexible tubing, so that when an external compression is applied to the chamber, the liquid contained therein is forcibly expelled. As the compression is removed, the metering chamber resumes its former shape and draws liquid into the chamber from the reagent reservoir. A dispensing assembly with electromechanical actuators for compression of the metering chamber and a means for sensing the amount of liquid contained within the reagent reservoir are also shown.

Murine T-cell receptors anti-NY-ESO-1

Human papillomavirus 16 E6 T-cell receptors

Receptor de células T (TCR) que tiene especificidad antigénica por virus del papiloma humano (VPH) 16 E6 y que comprende una región variable humana y una región constante murina, en el que el TCR comprende las secuencias de aminoácidos de SEQ ID NO: 3-8, y opcionalmente en el que: (i) el TCR tiene especificidad antigénica por VPH 16 E629-38 que comprende la secuencia de aminoácidos de SEQ ID NO: 2; (ii) el TCR comprende las secuencias de aminoácidos de SEQ ID NO: 15 y 16; (iii) el TCR comprende las secuencias de aminoácidos de SEQ ID NO: 17 y 18; y/o (iv) el TCR comprende las secuencias de aminoácidos de SEQ ID NO: 9 y 10. T-cell receptor (TCR) having antigenic specificity for human papilloma virus (HPV) 16 E6 and comprising a human variable region and a murine constant region, in which the TCR comprises the amino acid sequences of SEQ ID NO: 3 -8, and optionally wherein: (i) the TCR has antigenic specificity for HPV 16 E629-38 comprising the amino acid sequence of SEQ ID NO: 2; (ii) the TCR comprises the amino acid sequences of SEQ ID NO: 15 and 16; (iii) the TCR comprises the amino acid sequences of SEQ ID NO: 17 and 18; and / or (iv) the TCR comprises the amino acid sequences of SEQ ID NO: 9 and 10.

Cd24 as a brain tumor stem cell marker and a diagnostic and therapeutic target in primary neural and glial tumors of the brain

The present invention is directed to methods of treating a primary brain tumor and preventing the migratory spread of a primary brain tumor in a subject. These methods involve utilizing the CD24 surface protein selectively expressed on tumor progenitor cells as a therapeutic target as well as a means for directing oncolytic therapeutics directly to the tumor site. The present invention further relates to methods of diagnosing the presence of a brain tumor and monitoring the status of the brain tumor in a subject based on CD24 expression in tumor progenitor cells.

Absorbent article including ionic complexing agent for feces

An absorbent article adapted to receive feces having a first waist region, a second waist region opposed to the first waist region, a crotch region disposed between the first waist region and the second waist region. The absorbent article includes a liquid pervious topsheet a liquid impervious backsheet joined to at least a portion of the topsheet, an absorbent core disposed between at least a portion of the topsheet and the backsheet and an effective amount of an ionic complexing feces modifying agent disposed in the article such that the ionic complexing feces modifying agent is available to contact at least a portion of the feces deposited in the article.

Party tray

Identification and high-yield isolation of human pancreatic islet progenitor and stem cells

Adoptive immunotherapy with enhanced t lymphocyte survival

The invention provides for compositions, e.g., pharmaceutical compositions, comprising a T lymphocyte, or a population thereof, expressing at least one recombinant polynucleotide encoding a cytokine that enhances T lymphocyte survival during the contraction phase of an immune response. The invention further provides an isolated T lymphocyte, or population thereof, expressing at least one recombinant polynucleotide encoding the cytokine, wherein the polynucleotide comprises a non-native coding sequence encoding the cytokine. Also provided is the use of such compositions and T lymphocytes, or populations thereof, for the treatment or prevention of a medical condition e.g., cancer. A method of preparing the a T lymphocyte with enhanced T cell survival is further provided herein.

Oxidation catalyst with low pressure drop and high specific surface area and catalyst for the production of hydrogen cyanide.

Multi-functional dental composition

This invention relates to novel dental compositions and methods for preventing dental plaque and carie formation and generally for inhibiting tooth decay and brightening/whitening teeth. The compositions of this invention comprise organic acids such as acetic acid and salts thereof which can be combined with pharmaceutically acceptable carriers or diluents to be administered in the form of conventional dental compositions. The compositions of the present invention also preferably contain sodium hexametaphosphate.

Production of product comprising superconducting material

(57)【要約】 【課題】 超伝導材料からなる製品の新規な製造方法を 提供する。 【解決手段】 本発明の製造方法は、ペロブスカイト型 結晶構造を有する超伝導材料からなる製品の製造方法で あって、Ｂｉ、Ｓｒ、Ｃａ及びＣｕを含む出発材料を、 該超伝導材料が生成するように熱処理することからなる 方法において、該出発材料が、該熱処理工程後に、約１ ０５Ｋにおいて超伝導性を示す超伝導相を５０容量％以 上含む超伝導性材料を生成するのに有効な量のＰｂ含有 化合物を更に含んでいることからなる。

Methods of treating schizophrenia and other neuropsychiatric disorders

The present disclosure relates to methods of restoring K+ uptake by glial cells in a subject. These methods involve administering, to the subject, a SMAD4 inhibitor under conditions effective to restore K+ uptake by said glial cells. The present disclosure is also directed to methods of treating or inhibiting the onset of a neuropsychiatric disorder in a subject. These methods involve administering, to a subject in need thereof, a SMAD4 inhibitor under conditions effective to treat or inhibit the onset of the neuropsychiatric disorder in the subject.

Carbonate built laundry detergent composition

A powdered laundry detergent composition comprising an active surfactant, at least about 70 wt. % of a water soluble alkaline carbonate salt, e.g., sodium carbonate, about 0.1 to 2 wt. % of a phosphorus-containing sequestering agent, e.g., sodium tripolyphosphate (STPP), about 0.1 to 2 wt. % of a polymeric polycarboxylate, e.g., a polyacrylate or a polymaleate, and about 1-12 wt. % water. Use of the foregoing detergent composition provides excellent cleaning and whitening of fabrics while avoiding the problem of eutrophication which occurs when a substantial amount of a phosphorus containing builder such as STPP is present in the composition, and while minimizing the problem of fabric encrustation often present when the composition contains a large amount of carbonate builder.

Random access slide stainer with liquid waste segregation

An automated slide stainer with slides mounted in a horizontal position on a rotary carousel. Reagents and rinse liquids are automatically dispensed onto tissue sections or cells mounted on slides for the purpose of performing chemical or immunohistochemical stains. The rinse liquids are removed by an aspiration head (31) connected to a source of vacuum. The aspiration head (31) is a hollow chamber (40) with a flattened bottom aspect. Eight holes (41) in the bottom of the aspiration head provide for fluid communication between the exterior and interior of the aspiration head. To aspirate liquid off of a slide, the aspiration head is lowered so that the bottom aspect contacts the liquid. The liquid is sucked into the hollow interior (40) of the aspiration head and collected into a liquid waste collection bottle. Several different liquid waste collection bottles (59) are placed in parallel, between the source of vacuum and the aspiration head. A solenoid valve (80) is positioned in line with each liquid waste collection bottle. Depending upon which solenoid valve is opened, the operator can direct the liquid waste to be collected into a specified liquid waste collection bottle.

Polymorphisms associated with cardiac arrythmia

The invention relates generally to the discovery of specific nucleotide polymorphisms in the KCNE2 gene and the association of these polymorphisms with antibiotic-induced LQTS. Related composition screening systems and diagnostic and prognostic assays are provided.

Control for an industrial process using one or more multidimensional variables

A system for monitoring an industrial process and taking action based on the results of process monitoring. Actions taken may include process control, paging, voicemail, and input for e-enterprise systems. The system includes an input module for receiving a plurality of parameters from a process for manufacture of a substance or object. The system also includes a library module. The library module includes a plurality of computer aided processes. Any one of the computer aided processes is capable of using each of the plurality of parameters to compare at least two of the plurality of parameters against a training set of parameters. The training set of parameters is generally predetermined. The computer aided process is also capable of determining if the at least two of the plurality of parameters are within a predetermined range of the training set of parameters. Additionally, the system includes an output module for outputting a result based upon the training set and the plurality of parameters.

Selective chromate removal from a chlorate solution

ABSTRACT A method has been devised for removing hexavalent chromium from concentrated aqueous alkali metal chlorate solutions by reacting the solution with a hydrazine compound and separating trivalent chromium compound from the solution. Alkali metal hyprohalites may be simultaneously removed from a chlorate solu-tion by reaction with excess hydrazine compound.

T lymphocyte receptors recognizing MHC class II-restricted MAGE-A3

Un receptor de linfocitos T (TCR) aislado o purificado que comprende: (a) las SEQ ID NO: 3-8 o (b) una variante funcional de (a), en donde el TCR de (a) y la variante funcional de (b) se unen de manera específica a MAGE A3 que se presenta por HLA-DPβ1*04 y (ii) MAGE-A6, en donde la variante funcional comprende: (I) las SEQ ID NO: 3, 4, 6, 7, 8, y 29, en donde: (1) Xaa en 4 es Ala, Xaa en 5 es Ser, Xaa en 6 es Gly, y Xaa en 7 es Thr en la SEQ ID NO: 29; (2) Xaa en 4 es Ser, Xaa en 5 es Ala, Xaa en 6 es Gly, y Xaa en 7 es Thr en la SEQ ID NO: 29; (3) Xaa en 4 es Ser, Xaa en 5 es Ser, Xaa en 6 es Gly, y Xaa en 7 es Ala en la SEQ ID NO: 29; o (4) Xaa en 4 es Val, Xaa en 5 es Ser, Xaa en 6 es Gly y Xaa en 7 es Thr en la SEQ ID NO: 29; o (II) las SEQ ID NO: 3, 4, 5, 6, 7 y 30 en donde: (1) Xaa en 4 es Ala, Xaa en 5 es Thr, Xaa en 6 es Gly, y Xaa en 7 es Pro en la SEQ ID NO: 30; o (2) Xaa en 4 es Arg, Xaa en 5 es Ala, Xaa en 6 es Gly, y Xaa en 7 es Pro en la SEQ ID NO: 30, preferentemente en donde la variante funcional comprende (a) la SEQ ID NO: 29, en donde Xaa4 es Ala, Xaa5 es Ser, Xaa6 es Gly y Xaa7 es Thr, o (b) la SEQ ID NO: 29, en donde Xaa4 es Ser, Xaa5 es Ala, Xaa6 es Gly, y Xaa7 es Thr. An isolated or purified T-cell receptor (TCR) comprising: (a) SEQ ID NO: 3-8 or (b) a functional variant of (a), wherein the TCR of (a) and the functional variant of (b) specifically bind to MAGE A3 presented by HLA-DPβ1 * 04 and (ii) MAGE-A6, wherein the functional variant comprises: (I) SEQ ID NO: 3, 4, 6, 7 , 8, and 29, wherein: (1) Xaa at 4 is Ala, Xaa at 5 is Ser, Xaa at 6 is Gly, and Xaa at 7 is Thr in SEQ ID NO: 29; (2) Xaa at 4 is Ser, Xaa at 5 is Ala, Xaa at 6 is Gly, and Xaa at 7 is Thr in SEQ ID NO: 29; (3) Xaa at 4 is Ser, Xaa at 5 is Ser, Xaa at 6 is Gly, and Xaa at 7 is Ala in SEQ ID NO: 29; or (4) Xaa at 4 is Val, Xaa at 5 is Ser, Xaa at 6 is Gly, and Xaa at 7 is Thr in SEQ ID NO: 29; or (II) SEQ ID NO: 3, 4, 5, 6, 7 and 30 where: (1) Xaa at 4 is Ala, Xaa at 5 is ...

Process for preparing 2,6-dichloropyridine

The present invention relates to a process for preparing 2,6-dichloropyridine which comprises reacting an organic solvent-free, catalyst-free reaction mixture comprising 2-chloropyridine and chlorine in the presence of a hydrogen chloride scavenger and ultraviolet light, and optionally in the presence of added moisture, at a temperature of between about 90 °C and about 185 °C. Also claimed is a method for preventing calcium chloride plugging of the chlorine feed stream and for preventing calcium chloride build-up in the above reaction mixture which comprises adding moisture in the form of water or steam, or a combination thereof, to the reaction mixture prior to, or during, the reaction of said process.

Inhalation of nitric oxide

A method of treating a human subject which is effected by inhalation of gaseous nitric oxide over a period of 8 day to about 28 days is disclosed. The method can be utilized for treating a human subject suffering from, or prone to suffer from, a disease or disorder that is manifested in the respiratory tract, or from a disease or disorder that can be treated via the respiratory tract. The disclosed method can be effected while monitoring one or more of on- site and off-site parameters such as vital signs, methemoglobin levels, pulmonary function parameters, blood chemistry and hematological parameters, blood coagulation parameters, inflammatory marker levels, liver and kidney function parameters and vascular endothelial activation parameters, such that no substantial deviation from a baseline in seen in one or more of the monitored parameters.

Actuation mechanism for a tarping system

An open-topped vehicle body (13), includes a tarping system (16) that is deployed over the body by a pivoting bail member (22). An actuation mechanism (25) applies a torque to the bail member to automatically pivot the member and deploy the tarp. The actuation mechanism includes a number of double coil spiral torsion springs (50) anchored on a shaft (67) attached to the truck body. The springs each include a right hand (54) and a left hand (52) coil portion concentrically wound about an integral center anchor portion. The shaft includes an elongated slot (69) to receive and support the centre anchor portion of each spring within the mechanism. The housing contains the double coil springs and supports a pair of reaction posts (92) extending therethrough to which the reaction ends of the double coil springs can transfer their torsional force.

Aqueous composition for low-temperature metal-cleaning and method of use

An alkaline, aqueous metal-cleaning composition capable of effectively removing industrial-type soil contaminants from a metal surface at temperatures as low as ambient temperature and in the absence of substantial agitation contains (A) an active-ingredient portion containing (1) an alkalinity-providing component, and (2) a surfactant mixture containing: (a) at least one first non-ionic, ethoxylated linear primary alcohol surfactant having a hydrophobic carbon chain length of from 9 to 11 carbon atoms and being ethoxylated with (i) an average of 2.5 moles of ethylene oxide or (ii) an average of 5.0 moles of ethylene oxide; and (b) at least one second non-ionic, ethoxylated linear primary alcohol surfactant having a hydrophobic carbon chain length of from 9 to 11 carbon atoms and being ethoxylated with an average of 6.0 moles of ethylene oxide; and (B) an aqueous portion.

Gypsum composition

A gypsum composition comprising water, stucco, clay, an amine compound, a polyoxyalkylene, and a comb-branched copolymer is disclosed. The gypsum composition has improved fluidity. A method for preparing the gypsum composition is also disclosed. The method comprises mixing the components to form a slurry, casting the slurry into a product, and drying the product.

Dough forming apparatus and methods

An apparatus (10) for forming open ended, cone-shaped snack products includes a rotary cutter (28) having opposed, counterrotating rollers (30) each formed by multiple cutting discs (36) axially spaced on a mandrel (34) by spacers (38). A dough sheet formed by a sheeting device (12) is conveyed to a slitting device (24) which slits the dough sheet into multiple pairs of dough strips. The dough strips are after being twisted 90~, drawn under tension through the nip of the rollers (30) in a face to face stacked orientation. The snack products are cut and shaped by cavities (32) in the cutting discs (36).

Reduced windage high pressure turbine forward outer seal

A blocker and swirl inducer hole configuration for use in connection with a high pressure turbine is described. In one embodiment, the blocker holes are oriented to a 45-degree tangential angle with respect to the direction of rotation of the seal, which results in pre-swirling the air before being injected into the swirl cavity. In addition, the number of blocker holes is reduced by as much as 50% of the number of blocker holes used in the known CFM56 turbine. Further, rather than injecting the air into the first swirl cavity as is known, the air is injected into a second swirl cavity. The combined effect of orienting the holes to the 45-degree tangential angle with respect to the direction of rotation of the seal, locating the holes to open into the second swirl cavity, and reducing the flow area by about 50%, results in an increase in blocker hole pressure ratio. Increasing the blocker hole pressure ratio results in a higher hole exit velocity which maximizes the cavity inlet swirl. The blocker holes therefore not only provide back-pressure, but also function as swirl-inducers. By inducing swirl into the air injected into the second swirl cavity, better turbine disk rim cooling effectiveness is provided. This result facilitates maintaining reasonable metal temperatures at increasingly severe cycle conditions without the normally expected engine performance penalties.

Gaming device and method

Abstract A method and device (10) for gaming, in which a primary game is played s toward a winning outcome, and includes a bonus game that may be triggered by a particular outcome or outcomes. The bonus game is made up of a series of successive games centered around a common theme or directed toward a common outcome. 3508153_1 (GHMatters) P87923 AU.3 INITIALIZE WAGER PLAY PRIMARY GAME INCREMENT Y WIN PRIMARY GAME? CASH OUT CREDITS ID PNO BONUS ENABLED? NO PLAY AGAIN? YS SHOW TARGET PLAYER GUESSES INCREMENTYE CREDITS DID PLAYER MATCH? N SHOW SECOND BONUS SCREEN SPIN TO MOVE IS GAME OVER?YE - +NOINCREMENT GUESS INDICIA CRE DITS CORRECT INCREMENT ALL INDICIA GUESS? CREDITS CORRECT? Figure 1

Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation

The present invention provides a process for the preparation of enantiomerically enriched, deuterated secondary alcohols of Formula 1-A by employing ketoreductases or carbonyl reductases without reducing deuterium incorporation.

Defibrillator electrode adaptor

Disclosed is an adaptor (28, 90) for use with a paddle electrode equipped defibrillator (10) that allows alternative use of disposable defibrillation electrodes. In some applications, the adaptor (28, 90) is positioned and retained in the paddle electrode stowage region (18) of the defibrillator (10) with the paddle electrodes (14, 16) being retained in an accessible position by the adaptor. Electrical contacts (75) and a cable (34) that are included in the adaptor electrically connect the paddle electrodes (14, 16) with connectors for disposable defibrillation electrodes, which are mounted at the distal end of the adaptor cable (34). When disposable defibrillation electrodes (36, 38) are placed in the adaptor cable connectors and positioned on the body of a patient, a defibrillation sequence is carried out utilizing the same controls and sequence that are used to defibrillate with the paddle electrodes. In other applications, the adaptor (90) is affixed to a portion of the defibrillator cabinet (92) or another suitable place.

Neural progenitor cells from hippocampal tissue and a method for isolating and purifying them

The present invention relates to an enriched or purified preparation of isolated hippocampal neural progenitor cells and progeny thereof. The present invention also relates to a method of separating neural progenitor cells from a mixed population of cell types from hippocampal tissue. This method includes selecting a promoter which functions selectively in the neural progenitor cells, introducing a nucleic acid molecule encoding a fluorescent protein under control of said promoter into all cell types of the mixed population of cell types from hippocampal tissue, allowing only the neural progenitor cells, but not other cell types, within the mixed population to express said fluorescent protein, identifying cells of the mixed population of cell types that are fluorescent, which are restricted to the neural progenitor cells, and separating the fluorescent cells from the mixed population of cell types, wherein the separated cells are restricted to the neural progenitor cells.

Myelination of congenitally dysmyelinated forebrains using oligodendrocyte progenitor cells

Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders

Method for wire bonding an aluminum wire to a lead of an electronics package

A method is provided for wire bonding an aluminum wire to a surface of a lead of an electronics package. The method entails a nickel plating process and an ultrasonic bonding process which together cooperate to form a reliable and highly repeatable joint between the wire and the lead member. The ultrasonic bonding process is specifically tailored to the nickel plating produced by the plating process, so as to significantly enhance the bond strength of the resulting ultrasonic bond joint. The plating process is devised to produce a nickel plating which is thicker than that generally practiced, and whose surface is characterized as having a relatively smooth microfinish which unexpectedly serves to enhance the bond strength of the ultrasonic bond joint.

Flatbed Trailer Tarp System Affording Front and/or Rear Loading

A tarp system for a flatbed trailer is disclosed including front end, intermediate and rear end bow members that are all slidably moveable relative to the flat bed to permit the front and/or rear loading thereof, a cam device serving to displace the front and rear end bow members apart, thereby to tension the tarp cover carried by the bow members. A bump rail extends laterally outwardly from each flatbed side wall beyond an associated guide rail upon which are supported a plurality of carriages that carry the tarp supporting bows, thereby to improve the sealing of the lower side edges of the tarp cover and to protect the guide rails and the carriage from objects below.

Gaming method and apparatus including a simulation of a combination safe

A method and apparatus for simulating a gaming event in which a player is awarded outright for a winning combination and also allowed to participate in the incremental exposition of a potential reward subsequently based on losing, where the losing simulates unlocking the combination of a safe.

Detachable module disc and flat object storage system

Thiazolopyrimidine kinase inhibitors

Carton with tab

A foldable food carton including a lid portion; a bottom portion; and a viewable tab attached to the lid portion, wherein the tab comprises one or more of alphabetic text, numeric text, QR code, bar code, graphic, design, or combination thereof printed on the tab. A method of assembling a carton with a viewable tab, including providing a carton in an unfolded configuration, and folding the carton into an assembled configuration, wherein upon folding the carton into the assembled configuration the tab moves from a first position to a second position.

Network device measurements employing white boxes

A system for network device measurements may use a white box to perform measurements that may help determine the likelihood of network anomalies, such as microbursts.

Closeable container

Methods employing gaseous nitric oxide for inhibiting tumor growth

Methods of inhibiting growth of cells or tissue of a primary and/or secondary tumor, and/or of stimulating an immunological response to the tumor, in a subject in need thereof, and systems for performing same, are provided. The methods employ local administration of a gas, such as gaseous nitric oxide, typically at a high dose. Immune cells obtained upon treating a tumor with gaseous nitric oxide, either in vivo or ex vivo, and methods employing same are also provided.

Wheel and tire assembly

A wheel and tire assembly (10) comprises a wheel rim (14). A tire (12) is mounted on the wheel rim (14), the tire (12) and the wheel rim (14) enclosing an annular volume (16). A foam insert (24) only partially fills said annular volume (16), said foam insert (24) displacing air within the annular volume (16) and not being bonded to the tire (12), wherein said foam insert (24) maintaining its shape and its mass distribution within the tire (12).

Paint & ink remover two-phase system

A two-phase paint and ink stripper composition comprises an aqueous phase containing a basic activator in the form of an amino-alkyl-alkanol and an organic phase which contains an alkylene carbonate and organic solvents. The paint stripper composition of the present invention is free from methylene chloride and does not contain monoethanol amine.

INTERLEUCINE MONOCLONAL ANTIBODY-31

Un anticuerpo aislado que se enlaza de manera específica a por lo menos una de lnterleucina-31 (IL-31) canina o IL-31 felina. Dichos anticuerpos pueden estar en la forma de composiciones de diagnóstico y/o veterinarias útiles para tratar una condición de prurito y/o de alergia en perros o gatos.Reivindicación 1: Un anticuerpo aislado caracterizado porque se enlaza de manera específica a por lo menos una de una IL-31 canina o una IL-31 felina. An isolated antibody that specifically binds to at least one of canine lnterleucine-31 (IL-31) or feline IL-31. Said antibodies may be in the form of diagnostic and / or veterinary compositions useful for treating a condition of pruritus and / or allergy in dogs or cats. Claim 1: An isolated antibody characterized in that it specifically binds to at least one of a canine IL-31 or a feline IL-31.

Transverse rod connector

A transverse rod connector includes an elongate member having first and second ends and first and second connection members. The first and second connection members are connected with first and second ends, respectively. The first and second connection members are configured for multidirectional positioning with respect to the elongate member. The first and second connection members are each dimensioned to be selectively and releasably secured to a bone anchor.

Electrostatic field gradient sensor

A sensor for measuring disturbances to an electrostatic field caused by the intrusion of a charged body or a charge producing body. The sensor employs at least two probes displaced from each other which have attached beads of radioactive material to provide free ions in the vicinity of the probe. The free ions enhance the signal created by each probe when it is affected by a disturbance in the electrostatic field in which it resides. The signals thus created are conditioned for transmission to a differential amplifier which combines them and produces an output signal which represents the detection of an intruding charged body, its distance, and its characteristics. The sensor can be configured with more than two probes seeded or placed in an array and a computer for real-time selection of the two yielding optimum signals for charged body location, velocity, direction of travel, and electrostatic signature.

Actuation mechanism for a tarping system

An open-topped vehicle body (13), includes a tarping system (16) that is deployed over the body by a pivoting bail member (22). An actuation mechanism (25) applies a torque to the bail member to automatically pivot the member and deploy the tarp. The actuation mechanism includes a number of double coil spiral torsion springs (50) anchored on a shaft (67) attached to the truck body. The springs each include a right hand (54) and a left hand (52) coil portion concentrically wound about an integral center anchor portion. The shaft includes an elongated slot (69) to receive and support the centre anchor portion of each spring within the mechanism. The housing contains the double coil springs and supports a pair of reaction posts (92) extending therethrough to which the reaction ends of the double coil springs can transfer their torsional force.

Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders

The present invention provides pyrimidinyl substituted fused-pyrrolyl compounds of Formula (I) and pharmaceutical compositions comprising the compounds and methods of synthesis and use thereof. The compounds are kinase inhibitors useful in treating or ameliorating a kinase mediated, angiogenesis-mediated or hyperproliferative disorder. The invention thus also provides a therapeutic or prophylactic method of use for the compounds and/or pharmaceutical compositions to treat such disorders.

DETERGENT COMPOSITION CONTAINING STABLE BLEACHING ACTIVATING GRANULES.

COMPOSICION DETERGENTE QUE CONTIENE GRANULOS ESTABLES ACTIVADORES DE BLANQUEO. LA PRESENTE INVENCION PROPORCIONA GRANULOS ESTABLES ACTIVADORES DE BLANQUEO QUE COMPRENDE: A) UN ACTIVADOR DE BLANQUEO DE PEROXIGENO CON LA ESTRUCTURA: EN DONDE R ES C1-20 ALQUILO DE CADENA RAMIFICADA O RECTA, ALQUILO ALCOXILADO, CICLOALQUILO, ALQUENILO, ARILO, ARILO SUBSTITUIDO, ALQUILARILO; R'' Y R'''' SON INDEPENDIENTEMENTE H, C1-4 ALQUILO, ARILO; Y L ES UN GRUPO SALIENTE; B) UN MATERIAL AGLUTINANTE MANEJABLE SELECCIONADO DE LOS MATERIALES QUE TIENEN UNA TEMPERATURA DE TERMINACION DE FUSION SUPERIOR A UNOS 40 (GRADOS) C; Y C) UN ADYUVANTE SOLUBILIZANTE SELECCIONADO DEL GRUPO FORMADO POR SULFATO DE MAGNESIO, SULFONATO DE ARILO DE ALCALI, PIRROLIDONA DE POLIVINILO O SUS MEZCLAS. LA INVENCION TAMBIEN PUEDE INCLUIR MATERIALES DE RELLENO ADICIONALES, TALES COMO EL CALCIO O EL SILICATO DE MAGNESIO, O EL SILICE. DETERGENT COMPOSITION CONTAINING STABLE BLEACH ACTIVATING GRANULES. THE PRESENT INVENTION PROVIDES STABLE BLEACH ACTIVATORS, INCLUDING: A) A PEROXYGEN BLEACHING ACTIVATOR WITH THE STRUCTURE: WHERE R IS C1-20 BRANCH, RIGHT CHAIN, ALKYL ALKYL, ARKYL ALKYL, ARKYL, ALKYL ALKYLARYL; R '' AND R '' '' ARE INDEPENDENTLY H, C1-4 ALKYL, ARYL; AND L IS AN OUTGOING GROUP; B) A MANAGEABLE BINDING MATERIAL SELECTED FROM MATERIALS THAT HAVE A FUSION TERMINATION TEMPERATURE OF ABOVE 40 (C); AND C) A SELECTED SOLUBILIZING ADJUVANT FROM THE GROUP FORMED BY MAGNESIUM SULPHATE, ALCALI ARYL SULPHONATE, POLYVINYL PIRROLIDONE OR ITS MIXTURES. THE INVENTION MAY ALSO INCLUDE ADDITIONAL FILLING MATERIALS, SUCH AS CALCIUM OR MAGNESIUM SILICATE, OR SILICON.

Sodium bicarbonate vacuum bag inserts

A vacuum cleaner bag filter with one or more filter walls forming a generally air permeable enclosure having a bag opening through it, and a flange attached to the one or more filter walls to cover the bag opening. The filter walls have a working surface area through which air can pass during use, and the flange is a relatively rigid structure having an air inlet passing into the air permeable enclosure, One or more deodorizing sheets are attached to an inner surface of the one or more filter walls. The deodorizing sheets include a first sheet layer, and sodium bicarbonate particles operatively associated with the first sheet layer. The deodorizing sheets may cover less than about 30% of the working surface area, a single deodorizing sheet may be provided, and the deodorizing sheets may be attached to the filter walls by an air impermeable adhesive that covers at least about 5% of the surface area of the deodorizing sheets. Also provided is a vacuum cleaner filter having a filter and a deodorizing sheet attached thereto by an air-impermeable adhesive.

Gaming machine

Method for removing insoluble sulfide pads at oil/water interfaces

METHOD FOR REMOVING INSOLUBLE SULFIDE AT OIL/WATER INTERFACES Abstract of the Disclosure A method for removing insoluble metallic sulfide sludges present at oil/water interfaces by the addition of chlorine dioxide is described.

Cyanation of aromatic halides

A practical, ligand-free cyanation of aryl bromides employs Pd catalyst in combination with a non-toxic cyanide source, M n [Fe(CN) 6 ] (M=K or Na; n is 3 or 4), or a hydrate thereof, and a base. The reactions are performed in a polar aprotic solvents and provide the corresponding aryl nitrile in 83-96% yield, typically in less than 5 h.

Random access slide stainer with independent slide heating regulation

A microscope slide stainer, comprising: a staining protocol program comprising instructions for applying reagents and heat to a plurality of microscope slides bearing biological tissues; a plurality of slide supports, each support being comprised of a heating element and having a surface on which at least one microscope slide rests so as to transfer heat to the at least one microscope slide; at least one reagent dispenser that can dispense a liquid reagent onto a microscope slide; a movable carriage that causes the reagent dispenser to be aligned over a desired microscope slide, as specified in the staining protocol program, so that reagent dispensed out of the reagent dispenser drops onto an underlying microscope slide; and a control system that issues commands to cause relative motion of the reagent dispenser and microscope slide with respect to each other so that the reagent dispenser is aligned over a desired microscope slide, as specified in the staining protocol program, and that issues commands to cause the heating elements to heat at the times specified in the staining protocol program, the control system being capable of heating one heating element to a different temperature than another.

Methods for identifying erythropoietin receptor binding protein

The extracellular domain of the human erythropoietin receptor (EPO binding protein, EBP) has been expressed and overproduced in E. coli . Control of oxygen levels and pH during high density fermentation allows the production of only the protein variant with the native amino terminus. Methods disclosed permit the efficient recovery of purified EBP which quantitatively binds EPO. The active purified protein competes with membrane associated EPO receptor for binding [ 125 I]EPO and neutralizes EPO dependent stimulation in a cell based proliferation assay. Further, the radioligand equilibrium binding constant for this interaction has been determined by immobilizing EBP on agarose gel via a free cysteine. The EBP of the present invention has many uses including the structural determination of the protein by NMR or crystallography, in drug design and discovery, and as a therapeutic. A fusion protein of EBP and an immunoglobulin heavy chain was also produced. This protein, termed EBP-Ig, is a preformed dimerization template and is also useful in drug design and discovery methods.

Hub

Low pressure drop, high surface area ammonia oxidation catalyst

This invention is a catalytic element for use in the catalytic oxidation of ammonia. The element comprises a foraminous structure fabricated from a material consisting essentially of a metal selected from the group consisting of platinum, rhodium, palladium and alloys of mixtures thereof characterized by (a) a novel configuration whereby the initial product of the formula: curve to the flat ratio (C/F) multiplied by mesh count in inches (N) and wire diameter (d W ), for said element is at least about 0.08 and (b) where, for a given hydrogen throughput, the conversion efficiency is a function of the curve to flat ratio (C/F), wire diameter (d W ) and mesh count (N) combination and conversion efficiency is improved by increasing the mesh count (N) for a given wire diameter, increasing the wire diameter (d W ) for a given mesh count, and increasing the curve to flat ratio (C/F) to a ratio of above 1.0. Preferably the initial product of the formula is greater than 0.2, more preferably 0.9 and the curve to flat ratio (C/F) is above about π/2. The preferred initial product of the formula is in the range of from 0.08 to about 10 and more preferred from about 0.9 to about 10. The preferred element is woven gauze, knitted fabric, fibers and combinations thereof. The element can be in a series of said elements as a plurality of screens.

Referencing and rapid sampling in artificial olfactometry

Devices and methods are disclosed that are effective to produce reliable vapor measurements in the presence of drift. In certain instances the sensor module (14) is mounted externally on a housing. In other instances, the sensor module (14) contains a first sensor element incorporating a first array of sensors and a second element incorporating a second array of sensors and both sensor elements are mounted externally on the housing. The present invention relates to mapping an x-y surface for detection of an analyte, includes moving in tandem at least two sensor arrays separated by a distance "d" across an x-y surface to produce a plurality of responses and analyzing the responses to map the x-y surface for detection of an analyte. Moreover, a sensor module (14) is provided, such as in a handheld device (10), comprising at least two pneumatic vapor paths and at least two sensor arrays. The dual pneumatic train allows rapid sensing as it increases the duty cycle frequency.