Metatarsal hemiarthroplasty implant

An implant for metatarsal hemiarthroplasty according to embodiments of the present invention includes a resurfacing body configured to at least partially resurface distal and dorsal surfaces of an articular head of a metatarsus, the resurfacing body including a first side and a second side, the first side configured to articulate against a phalange associated with the metatarsus, the first side including a convex surface formed of ceramic, the second side configured to be fixed to the metatarsus, the second side including a concave surface from which protrude at least two immobilization elements, the at least two immobilization elements configured to interface with the articular head.

Microfabricated calorimeter for rf power measurement

Disclosed is a radio frequency (RF) power calorimeter having a load electrically coupled to a RF input, a variable low-frequency power source electrically coupled to the load and configured to apply low-frequency bias to the load. The RF power calorimeter includes a thermal medium thermally coupled to the load. Additionally, the RF power calorimeter includes an outlet temperature sensor thermally coupled to the thermal medium, the outlet temperature sensor being positioned to measure the temperature of the thermal medium due to heating by the load. The RF power calorimeter also has circuitry configured to use temperature measurements of the thermal medium in thermal contact with an RF load in combination with the low-frequency bias to measure average power of an RF source electrically coupled to the RF input. Also disclosed in a method of measuring RF power using the RF power calorimeter.

Coherency of data in data relocation

At least one attribute defined by a host is used to identify data and/or a location for a destination portion for relocating data from a source portion to the destination portion. The data is relocated from the source portion to the destination portion in accordance with the identification of the data to be relocated and/or the location for the destination portion, and it is determined if a change was made to relevant data stored in the source portion while relocating the data from the source portion to the destination portion. If a change was made to relevant data stored in the source portion while relocating the data to the destination portion, the changed relevant data is relocated from the source portion to the destination portion.

Bottle filling/capping methods and apparatus

A bottle handling apparatus handles bottles ( 50 ) of a nominal neck ( 70 ) radius. The apparatus has a carrier ( 140 ) and a plurality of bottle guides ( 100; 180; 200 ) mounted to the carrier and each comprising a bottle-engaging recess ( 110 ). The bottle-engaging recess accommodates necks of different eccentricities.

Adjustable toe curve knuckle for a vehicle suspension and method

An adjustable knuckle/steer arm assembly and method for adjusting a toe curve setting of a vehicle wheel is provided. The adjustable knuckle/steer arm assembly includes a knuckle and a steer arm. The steer arm is pivotally connected to the knuckle at a pivot. One of the knuckle and the steer arm has a slot formed therein and the other has a connector member which engages the slot. The steer arm is angularly adjustable with respect to the knuckle via adjustable engagement of the connector member along the slot to enable the toe curve setting to be adjusted.

Accurate magnetic biosensor

The invention provides a method, a device and a system for determining the concentration of at least one sort of targets in a fluid containing at least one sort of polarizable of polarized magnetic labels in a fluid, the sensing surface comprising at least one sort of binding sites capable to specifically attach to at least one sort of biological entities linked to the magnetic labels, the sensing device further comprising at least one magnetic sensor element, the sensing device further comprising distinction means for time-resolved distinguishing between magnetic labels specifically attached to the binding sites versus labels non-specifically attached. The method and device according to the present invention may be applied to biomolecular diagnostics.

Biosensor with multi-chamber cartridge

The present invention provides a biosensor comprising a cartridge for accommodating a fluid sample, the cartridge comprising at least two chambers, wherein each chamber comprises a sensor surface with one or more binding sites. The biosensor further comprises means for generating a magnetic field at the binding sites of the sensor surfaces of the at least two chambers. The biosensor also comprises means for detecting particles accumulated at/and or proximate the binding sites of the sensor surfaces of the at least two chambers. Therein, the magnetic field at the binding sites has a sufficiently large gradient to actuate magnetic label particles towards the binding sites.

Magnetic sensor device, method of operating such a device and sample

A sensor device (1) for detecting the presence of a target molecule (20) in a sample, is disclosed. The sensor device comprises a measurement sensor (2) comprising a first moiety (16) for forming a binding couple with a first further moiety comprising the target molecule (20) and a detectable label (40) and a reference sensor (3) comprising a second moiety (50) for forming a further binding couple with a second further moiety comprising a further detectable label (40'). The sensor device is adapted to generate a first detection signal (14) from the detection of the detectable label (40) in the first further moiety bound to the first moiety (16) and to generate a second detection signal (14') from the detection of the further detectable label (40') in the second further moiety bound to the second moiety (50), wherein at least during operation of the sensor device the second further moiety is expected to be present in a predefined amount such that the value of the second detection signal (14') falls within an expected signal value window when the binding reaction of the second further moiety to the second moiety takes place as expected. An apparatus comprising such a sensor device, methods of operating the sensor device and apparatus and a sample for use with the sensor device are also disclosed.

Sensing device and method for determination of the amount of target molecule in an analyte

A sensing device is provided which has a universal sensor surface. This allows easy modification of the detection properties without the need for investigation of the binding properties of a new target to the sensor surface. The device comprises a sensor surface, which has attached thereto a primary capture molecule. The invention further relates to a method for measurement of a target wherein this device is used.

Accurate magnetic biosensor

The invention provides a method, a device and a system for determining the concentration of at least one sort of targets in a fluid containing at least one sort of polarizable of polarized magnetic labels in a fluid, the sensing surface comprising at least one sort of binding sites capable to specifically attach to at least one sort of biological entities linked to the magnetic labels, the sensing device further comprising at least one magnetic sensor element, the sensing device further comprising distinction means for time-resolved distinguishing between magnetic labels specifically attached to the binding sites versus labels non-specifically attached. The method and device according to the present invention may be applied to biomolecular diagnostics.

Accurate magnetic biosensor

A method is provided for determining the concentration of target in a fluid sample using a magnetic label and a magnetic sensor for detection. It was surprisingly found that efficient and accurate measurements can be carried out by determination of a signal as soon as the signal has reached a specified threshold level. In an alternative embodiment, a displacement step is used as soon as the signal has reached a pre-defined threshold level.

Combined optical and electrical sensor cartridges

A sensor cartridge has a cartridge substrate comprising an optical substrate for optical detection of a target moiety in a sample fluid based on frustrated totalinternal reflection and at least one electric structure. This way, optical read-out and electrical functions, e.g. read-out, are combined in a single substrate, in a simple and cheap manner. Also a method of fabricating such sensor cartridge is provided.

A method for determining the concentration of at least one type of target in a fluid containing at least one type of polarized or polymerizable magnetic markers.

MéTODO PARA DETERMINAR A CONCENTRAçãO DE PELO MENOS UM TIPO DE ALVOS EM UM FLUIDO CONTENDO PELO MENOS UM TIPO DE MARCADORES MAGNéTICOS POLARIZADOS OU POLIMERIZáVEIS. Um método é fornecido para determinar a concentração de alvo em uma amostra de fluido usando um marcador magnético e um sensor magnético para detecção. De modo surpreendente foi encontrado que medidas eficientes e precisas podem ser realizada através da determinação de um sinal assim que o sinal atinge um nível de limite especificado. Em uma modalidade alternativa, um estágio de deslocamento é usado assim que o sinal atinge um nível de limite pré-especificado. METHOD FOR DETERMINING THE CONCENTRATION OF AT LEAST ONE TYPE OF TARGETS IN A FLUID CONTAINING AT LEAST A TYPE OF POLARIZED OR POLYMERIZABLE MAGNETIC MARKERS. A method is provided for determining target concentration in a fluid sample using a magnetic marker and a magnetic sensor for detection. Surprisingly it has been found that efficient and accurate measurements can be performed by determining a signal as soon as the signal reaches a specified threshold level. In an alternative embodiment, an offset stage is used as soon as the signal reaches a pre-specified threshold level.

Magnetic sensor device

The present invention provides a magnetic sensor device (20) for determining the presence and/or amount of target moieties (32) in a sample fluid, the target moieties being labeled with magnetic or magnetizable objects (33). The magnetic sensor device (20) comprises a sensor surface (23) lying in a plane, at least one magnetic element (21) for providing a sensor signal and at least one structure (24) extending from the sensor surface (23) in a direction substantially perpendicular to the plane of the sensor surface (23), the at least one structure (24) having a height (h) and a binding surface (25) for binding the labeled target moieties (32). The height (h) of the at least one structure (24) is higher than zero and lower or equal to a distance (z) of the labeled target moieties (32) from the sensor surface (23) corresponding to a signal cross-over point (27) from positive to negative signal contribution of the labeled target moieties (32) to the sensor signal, the signal cross-over point (27) being the distance at which a homogeneous distribution of magnetic or magnetizable objects (33) between the sensor surface (23) and that distance has a signal contribution to the sensor signal equal to zero.

Accurate magnetic biosensor

A method is provided for determining the concentration of target in a fluid sample using a magnetic label and a magnetic sensor for detection. It was surprisingly found that efficient and accurate measurements can be carried out by determination of a signal as soon as the signal has reached a specified threshold level. In an alternative embodiment, a displacement step is used as soon as the signal has reached a pre-defined threshold level.

Magnetic manipulation device for magnetic beads

The invention relates to a magnetic manipulation device (110) that can for example be integrated into a magnetic biosensor (100). The magnetic manipulation device (110) comprises at least one core structure (111) with an array of fingers (113) carrying coils (114) which can selectively be supplied with excitation currents by a controller (115). The core structure (111) has preferably a comb-like form and may for example extend along channels (12) of an exchangeable microfluidic device (10) in which a sample with magnetic target particles can be provided. The controller (115) is preferably adapted to generate moving activity patterns.

Sensor device for target particles in a sample

The invention relates to a sensor device(100) and a method for the determination of the amount of target particles(1) at a contact surface(112) adjacent to a sample chamber(2). Target particles(1) in the sample chamber are detected by a sensor element(SE) and at least one corresponding sensor-signal (s, s') is provided. An evaluation unit(EU) then determines the amount of target particles(1) in a first zone(Z1) immediately at the contracts surface(112) and a second zone(Z2) a distance(z) away from the contact surface based on this sensor-signal. In an optical measurement approach, frustrated total internal reflection taking place under different operating conditions (e.g. wavelength, angle of incidenceq) may be used to extract information about the first and second zones(Z1, Z2). In a magnetic measurement approach, different magnetic excitation fields may be used to excite magnetic target particles differently inthe first and second zone(Z2). Moreover, the temporalcourse of a sensor-signal(s, s') can be evaluated, particularly with respect to stochastic movements ofthe target particles(1).

Magnetic washing for biosensor

Detecting magnetized or magnetizable target components in a fluid containing the magnetized or magnetizable target components amongst other magnetized or magnetizable components, uses a magnetic field generator (M1, 28) to attract the magnetized or magnetizable components towards a binding surface. A magnetic field controller (C1) applies the magnetic field to concentrate the magnetized or magnetizable components in columns on the binding surface, subsequently reduces the magnetic field to enable the columns to collapse, to allow more components to reach the binding surface, and reapplies the magnetic field so as to cause other components to be pulled off the binding surface to reform columns based on the bound target components. A surface sensitive sensor (S1, 26, 29) detects the bound magnetized or magnetizable target components. The reapplication of the magnetic field acts as a magnetic washing step to release unwanted aspecific adsorption binding, leaving the targets, to improve sensitivity with simplified hardware and a reduction in cost and size.

Magnetic washing for biosensor

Detecting magnetized or magnetizable target components in a fluid containing the magnetized or magnetizable target components amongst other magnetized or magnetizable components, uses a magnetic field generator (M1, 28) to attract the magnetized or magnetizable components towards a binding surface. A magnetic field controller (C1) applies the magnetic field to concentrate the magnetized or magnetizable components in columns on the binding surface, subsequently reduces the magnetic field to enable the columns to collapse, to allow more components to reach the binding surface, and reapplies the magnetic field so as to cause other components to be pulled off the binding surface to reform columns based on the bound target components. A surface sensitive sensor (S1, 26, 29) detects the bound magnetized or magnetizable target components. The reapplication of the magnetic field acts as a magnetic washing step to release unwanted aspecific adsorption binding, leaving the targets, to improve sensitivity with simplified hardware and a reduction in cost and size.

Method for detecting redispersion of beads

Magnetoresistive sensor as temperature sensor

A detection system (100, 150) for qualitative or quantitative detection of a magnetic field property of a modulated magnetic field is described. The modulated magnetic field may e.g. stem from an adjacent electrical current (Iadj) or magnetic particles. The detection system (100, 150) comprises at least one magneto resistive sensor element (102), a current controller (104) for providing a sensing current (Isense) flowing through the magnetic sensor element (102) and a controlling means (108). The controlling means (108) is adapted for deriving at a first frequency f1 a temperature-related parameter of the at least one magneto resistive sensor. The controlling means (108) furthermore is adapted for deriving a qualitative or quantitative characteristic of the adjacent electrical current (Iadj) or magnetic particles, taking into account the derived temperature-related parameter. This second frequency (f1) is different from the first frequency (f1}). The invention also relates to a corresponding method.

Sensor device for target particles in a sample

The invention relates to a sensor device(100) and a method for the determination of the amount of target particles(1) at a contact surface(112) adjacent to a sample chamber(2). Target particles(1) in the sample chamber are detected by a sensor element(SE) and at least one corresponding sensor-signal (s, s') is provided. An evaluation unit(EU) then determines the amount of target particles(1) in a first zone(Z1) immediately at the contracts surface(112) and a second zone(Z2) a distance(z) away from the contact surface based on this sensor-signal. In an optical measurement approach, frustrated total internal reflection taking place under different operating conditions (e.g. wavelength, angle of incidenceq) may be used to extract information about the first and second zones(Z1, Z2). In a magnetic measurement approach, different magnetic excitation fields may be used to excite magnetic target particles differently inthe first and second zone(Z2). Moreover, the temporalcourse of a sensor-signal(s, s') can be evaluated, particularly with respect to stochastic movements ofthe target particles(1).

Method for detecting redispersion of beads

The invention provides a method ofdetecting the redispersion of particles into a solution by means of FTIR or other optical detection methods comprising the following steps: providing a sensor surface with dry particles; illuminating the sensor surface with light along a first optical path and detecting the light reflected by the sensor surface; providing a liquid to a volume in contact with the sensor surface; and detecting the reflected light while the dryparticles redisperse into the liquid. Therein, the angle between first optical path and sensor surface fulfils the condition of total internal reflection. The present invention also provides an FTIR cartridge for use in said method comprising a sensor surface accessible for FTIR detection, said sensor surface comprising at least one binding area, wherein label particles are situated on said surface.

Accurate magnetic biosensor

The invention provides a method, a device and a system for determining the concentration of at least one sort of targets in a fluid containing at least one sort of polarizable of polarized magnetic labels in a fluid, the sensing surface comprising at least one sort of binding sites capable to specifically attach to at least one sort of biological entities linked to the magnetic labels, the sensing device further comprising at least one magnetic sensor element, the sensing device further comprising distinction means for time-resolved distinguishing between magnetic labels specifically attached to the binding sites versus labels non-specifically attached. The method and device according to the present invention may be applied to biomolecular diagnostics.

Magnetoresistive sensor as temperature sensor

A detection system (100, 150) for qualitative or quantitative detection of a magnetic field property of a modulated magnetic field is described. The modulated magnetic field may e.g. stem from an adjacent electrical current (Iadj) or magnetic particles. The detection system (100, 150) comprises at least one magneto resistive sensor element (102), a current controller (104) for providing a sensing current (Isense) flowing through the magnetic sensor element (102) and a controlling means (108). The controlling means (108) is adapted for deriving at a first frequency f1 a temperature-related parameter of the at least one magneto resistive sensor. The controlling means (108) furthermore is adapted for deriving a qualitative or quantitative characteristic of the adjacent electrical current (Iadj) or magnetic particles, taking into account the derived temperature-related parameter. This second frequency (f1) is different from the first frequency (f1}). The invention also relates to a corresponding method.

Sensor device for target particles in a sample

The invention relates to a sensor device(100) and a method for the determination of the amount of target particles(1) at a contact surface(112) adjacent to a sample chamber(2). Target particles(1) in the sample chamber are detected by a sensor element(SE) and at least one corresponding sensor-signal (s, s') is provided. An evaluation unit(EU) then determines the amount of target particles(1) in a first zone(Z1) immediately at the contracts surface(112) and a second zone(Z2) a distance(z) away from the contact surface based on this sensor-signal. In an optical measurement approach, frustrated total internal reflection taking place under different operating conditions (e.g. wavelength, angle of incidenceq) may be used to extract information about the first and second zones(Z1, Z2). In a magnetic measurement approach, different magnetic excitation fields may be used to excite magnetic target particles differently inthe first and second zone(Z2). Moreover, the temporalcourse of a sensor-signal(s, s') can be evaluated, particularly with respect to stochastic movements ofthe target particles(1).

Biosensor with multi-chamber cartridge

The present invention provides a biosensor comprising a cartridge for accommodating a fluid sample, the cartridge comprising at least two chambers, wherein each chamber comprises a sensor surface with one or more binding sites. The biosensor further comprises means for generating a magnetic field at the binding sites of the sensor surfaces of the at least two chambers. The biosensor also comprises means for detecting particles accumulated at/and or proximate the binding sites of the sensor surfaces of the at least two chambers. Therein, the magnetic field at the binding sites has a sufficiently large gradient to actuate magnetic label particles towards the binding sites.

Sensor device for target particles in a sample

The invention relates to a sensor device(100) and a method for the determination of the amount of target particles(1) at a contact surface(112) adjacent to a sample chamber(2). Target particles(1) in the sample chamber are detected by a sensor element(SE) and at least one corresponding sensor-signal (s, s') is provided. An evaluation unit(EU) then determines the amount of target particles(1) in a first zone(Z1) immediately at the contracts surface(112) and a second zone(Z2) a distance(z) away from the contact surface based on this sensor-signal. In an optical measurement approach, frustrated total internal reflection taking place under different operating conditions (e.g. wavelength, angle of incidenceq) may be used to extract information about the first and second zones(Z1, Z2). In a magnetic measurement approach, different magnetic excitation fields may be used to excite magnetic target particles differently inthe first and second zone(Z2). Moreover, the temporalcourse of a sensor-signal(s, s') can be evaluated, particularly with respect to stochastic movements ofthe target particles(1).

Microelectronic sensor device for optical examinations on a wetted surface

The application relates to a method and a microelectronic sensor device for making optical examinations in an investigation region (13) at the contact surface (12) of a carrier (10), wherein an input light beam (L1, L1') is sent from a light source (20) towards the investigation region (13), and wherein an output light beam (L2, L2') coming from the investigation region (13) is detected by a light detector (30). An evaluation unit (50) that is coupled to the light detector (30) is adapted to determine the wetting grade of the investigation region (13) based on a characteristic parameter of the output light beam (L2, L2'), e.g. its intensity. In a preferred embodiment, the evaluation unit (50) is adapted to determine a change in the light intensity caused by a liquid contacting the contact surface (12). The wetting grade may particularly be detected in a test region (14) that is located adjacent to the investigation region (13) and that has a higher roughness than the investigation region (13).

Sensor device for target particles in a sample

The invention relates to a sensor device(100) and a method for the determination of the amount of target particles(1) at a contact surface(112) adjacent to a sample chamber(2). Target particles(1) in the sample chamber are detected by a sensor element(SE) and at least one corresponding sensor-signal (s, s') is provided. An evaluation unit(EU) then determines the amount of target particles(1) in a first zone(Z1) immediately at the contracts surface(112) and a second zone(Z2) a distance(z) away from the contact surface based on this sensor-signal. In an optical measurement approach, frustrated total internal reflection taking place under different operating conditions (e.g. wavelength, angle of incidenceq) may be used to extract information about the first and second zones(Z1, Z2). In a magnetic measurement approach, different magnetic excitation fields may be used to excite magnetic target particles differently inthe first and second zone(Z2). Moreover, the temporalcourse of a sensor-signal(s, s') can be evaluated, particularly with respect to stochastic movements ofthe target particles(1).

Microelectronic sensor device for optical examinations in a sample medium

The invention relates to a microelectronic sensor device with a light source (21) for emitting an input light beam (L1) into a transparent carrier (11) such that it is totally internally reflected at a contact surface (12) as an output light beam (L2), which is detected by a light detector (31). Frustration of the total internal reflection at the contact surface (12) can then for example be used to determine the amount of target particles (1) present at this surface. The sensor device further comprises a refractive index measurement unit (100, 200, 300) for measuring the refractive index (nB) of the sample medium, and an evaluation unit (50) for evaluating the measurement of the light detector (31) taking the measured refractive index (nB) into account and/or for changing the conditions of total internal reflection of the input light beam (L1). The refractive index measurement unit may particularly be designed to infer the refractive index (nB) from the deflection of a test-light beam (L3) that is transmitted through the sample medium, or from a reflection of a test-light beam (L1) at an interface (12) to the sample medium. In the latter case, it is possible to determine the critical angle of total internal reflection and/or to measure the reflectivity of the interface.

Fluid providing apparatus

The invention relates to a fluid providing apparatus (5; 34) for providing a fluid to an analyzing apparatus (17; 33) for analyzing the fluid and to the analyzing apparatus (17; 33). The fluid providing apparatus (34) comprises a casing (35), which has an introduction opening (7), through which a fluid transferring element (1) is introducible into the casing (35) for transferring the fluid to the fluid providing apparatus (34). The casing (35) comprises further a fluid releasing section (8) for releasing the fluid from the fluid transferring element (1) and a fluid transferring element detection section (36) for detecting whether the fluid transferring element (1) is introduced into the casing (35) by interacting with a fluid transferring element detection unit of the analyzing apparatus (17; 33).

Fluid providing apparatus

The invention relates to a fluid providing apparatus (5; 34) for providing a fluid to an analyzing apparatus (17; 33) for analyzing the fluid and to the analyzing apparatus (17; 33). The fluid providing apparatus (34) comprises a casing (35), which has an introduction opening (7), through which a fluid transferring element (1) is introducible into the casing (35) for transferring the fluid to the fluid providing apparatus (34). The casing (35) comprises further a fluid releasing section (8) for releasing the fluid from the fluid transferring element (1) and a fluid transferring element detection section (36) for detecting whether the fluid transferring element (1) is introduced into the casing (35) by interacting with a fluid transferring element detection unit of the analyzing apparatus (17; 33).

Optical detection of particles in a magnetic biosensor using a waveguide

The present invention provides a biosensor device comprising a sensor surface and an optical wave guide having an input, an output and first and second surfaces, said optical wave guide (5) being adapted to direct light entering the optical wave guide (5) through the input (20) to the output (21) via multiple reflections on said first and second surfaces (22, 23) including at least one reflection onsaid first surface (22) under an angle fulfilling the condition of total internal reflection, wherein the sensor surface is adjacent to the first surface of total internal reflection.

Sensor cartridge

The present invention provides a sensor cartridge (10) for distinctively determining at least two different target moieties in a fluid sample. The sensor cartridge (10) comprises a reaction chamber (1) and at least a first and second region (2, 3) distinct from each other. The first region (2) comprises magnetic or magnetizable objects (4a) labelled with a first type of probes for specifically binding a first type of target moieties and the second region (3) comprises magnetic or magnetizable objects (4b) labelled with a second type of probes for specifically binding a second type of target moieties, the magnetic or magnetizable objects (4a, 4b) in the first and second region (2, 3) being directly contactable by the sample fluid. The present invention also provides a method for the manufacturing of such sensor devices (10) and a method for determining the presence and/or amount of at least two different target moieties in a sample fluid using such sensor cartridge (10).

Process for forming shaped articles of ultra high molecular weight polyethylene suitable for use as a prosthetic device or a component thereof

Disclosed is a method of producing a shaped article suitable for use as the load bearing component of a prosthetic device formed from ultrahigh molecular weight polyethylene. polyethylene.

Joint prosthesis

A knee joint prosthesis comprises femoral and tibial components. The femoral component includes a pair of condyles each curved generally to match the shape of an anatomical femoral condyle. The surface of each condyle is defined by (a) anterior posterior radii R CF and R CE , wherein R CF is the radius of curvature Of that portion of the condyle which is weight bearing in flexion and R CE represents that portion of the curvature of the condyle which is weight bearing in extension, and (b) a medial lateral radius R CML . The tibial component includes a pair of concavities, each of which is adapted to receive one of the condyles of the femoral component. The surfaces of the concavities are defined by an anterior posterior radius R TAP and a medial lateral radius R TML . The foregoing radii are selected to optimize the balance between range of motion and knee longevity.

Self monitoring/calibrating phased array radar and an interchangeable, adjustable transmit/receive sub-assembly

The invention relates to a self monitoring/calibrating phased array radar in which the operating path for transmission and the operating path for reception may be monitored/calibrated by the addition of a corporate calibration network coupled at the plural end to the antenna elements and at the singular end to the exciter/receiver, and switching means to selectively route the monitoring/calibrating signal derived from the exciter in a transmit path to calibration path sequence or in a calibration path to receive path sequence. In one embodiment of the invention, a phase shifter common to transmit and receive paths is adjustable in increments under active logical control for calibration, while power and gain performance is monitored but not actively controlled. A novel T/R sub-assembly houses the operating electronics for four antenna elements in the form of four T/R modules with a one to four divider network in the transmit/receive path and in the calibration path. The four antenna elements are an integral part of the T/R sub-assembly.

Monitoring in communication system with wireless trunk

A communication system having a wireless trunk for connecting multiple phone lines over wireless communication links to a cellular network comprises a central telephone switch, such as a private branch exchange or key system, connected through one or more trunk lines to a wireless access communication unit. The wireless access communication unit preferably comprises a separate subscriber interface for each trunk line from the central telephone switch. The wireless access communication unit collects data from each of the subscriber interfaces, formats the data into a format compatible with an over-the-air protocol, and transmits the information over one or more wireless channels to a cellular base station. The wireless access communication unit thereby connects calls received from the central telephone switch's trunk lines over a wireless trunk to a network. A controller within the wireless access communication unit interfaces the subscriber interfaces with a radio transceiver, and assists in the conversion of data from a format suitable for wireless transmission. The controller also assists in distributing data received over the wireless trunk to the separate subscriber interfaces, and converting the data to a format suitable for communication with the central telephone switch. Calls may be selectively routed by the central telephone switch over landlines, instead, to the wireless access communication unit, thereby bypassing landlines.

Method of replicating a high resolution three-dimensional imprint pattern on a compliant media of arbitrary size

A method for replicating a high resolution three-dimensional imprint pattern on a compliant media is disclosed. The compliant media carries an imprint stamp that includes three-dimensional features that can be used as an imprint stamp in a roll-to-roll transfer printing process. The compliant media can be made to any size and can be connected with a belt or a cylinder. The compliant media can be optically transparent and the belt or cylinder can be optically transparent so that a light source positioned inside or outside the belt or the cylinder can irradiate another media that is urged into contact with the compliant media.

Apparatus for embossing a flexible substrate with a pattern carried by an optically transparent compliant media

An apparatus for embossing a flexible substrate with an optically transparent compliant media is disclosed. The complaint media includes an optically transparent imprint stamp with an imprint pattern therein. The flexible substrate is coated with a photopolymer material. The compliant media can be connected with an optically transparent belt material to form an embossing belt or connected with an optically transparent cylinder to from an embossing drum. A coated side of the flexible substrate is urged into contact with the imprint stamp and the imprint pattern is embossed in the photopolymer material and an ultraviolet light passing through the compliant media contemporaneously cures the photopolymer material during the embossing.

Method and apparatus for detecting and reporting a power outage

A method and apparatus for detecting a power outage within an energy meter a nd alerting a remote central computer about the outage using call-in reporting via modem (35) within the meter to a telephone numbe r designated for outage reporting. A primary battery cell or pack (55) is placed inside the meter (40) to operate the modem (35) when lin e power is lost. The modem (35) switches from a line power source in the meter (40) to the battery source (55) when an outage is detect ed and is to be reported to the remote central computer as an outage call. The battery source (55) is switched off when the outage is completed or aborted. The number of retries to call to report the power outage and the time period between retries is programmable.

Hip joint prosthesis

ABSTRACT OF THE DISCLOSURE The stem of the femoral component of a hip joint prosthesis is of a cross-sectional shape that is generally rounded about a large portion of the periphery and is truncated at a flattened lateral side. This shape minimizes stress in the stem when the composite structure is intact and when the proximal support for the stem has been lost and minimizes the decrease in stress in the bone (compared to the anatomical state) when the composite prosthetic structure is intact. .

Method and apparatus for femoral resection

An instrument is provided for use in shaping a femur preparatory to implantation of a knee prosthesis. A gap checking device (40) is fixed to the distal end of the patient's femur and referenced to the epicondyles of the femur. The gap checking device (40) includes slots (70, 72, 74, 76, 78) through which a cutting instrument can be passed to shape the femur so that it can receive the femoral component of the prosthesis. One of the slots (70) enables the distal femoral cut to be made. The thickness of the gap setting device (40) is selected so that the distance between the distal femoral cut and the distal surface of the gap setting device plus the thickness of a shim resting on the cut proximal tibial surface is equal to the combined thickness of the tibial and femoral components of the prosthesis. This enables the flexion and extension gaps to be checked before the femoral cuts are made. The epicondyles can be located using intramedullary or extramedullary referencing. A special extramedullary locating device (10) is also described which is referenced to the trochlear groove of the femur and enables the placement of pins (38) in the epicondyles so that the gap checking device (40) can be properly situated with respect to the femur.

Dashpot

A device for collecting a biological fluid sample

Sample collection device (10; 20; 30) for collecting a fluidic biological sample, the device comprising a collecting member (11; 21; 31) for collecting the fluidic sample; an indicator element (12, 22, 32) for providing an indication that a desired amount of the fluidic sample has been collected; an elongatedcapillary element (13; 23; 33) for providing fluidic communication between the collecting member (11; 21; 31) and the indicator element (12; 22; 32) so that at least a portion of the fluidic sample may be transferred from the collecting member (11; 21; 31) to the indicator element (12; 22; 32). The invention relates also to a sample test assembly.

Vibratory exercise table

Method and apparatus for a network connected storage system

A Data Storage Device (DSD) includes a Non-Volatile Memory (NVM) for storing data, a network interface for communicating on a network, and a processor. According to one aspect, a command is received via the network interface for storing data in the NVM or retrieving data from the NVM. Based on a transport attribute of the command, it is determined whether to execute a file interface for accessing files stored in the NVM or an object interface for accessing data objects stored in the NVM. According to another aspect, computer-executable instructions are received from a device via the network interface and the computer-executable instructions are executed using an off-load interface. The computer-executable instructions cause the processor to transform data stored in the NVM or data received from the network and send the transformed data to another device on the network or store the transformed data in the NVM.

Automotive heating system

Magneto optical recording system

An actuator (6) for a magneto optical recording apparatus (1) comprises an actuator base (20); a platform (30) movably coupled to said actuator base (20); at least one actuator coil (31) supported by said platform (30); at least one writing coil (43) supported by said platform (30). One common conductor (22a; 22b) conducts actuator coil drive signals as well as writing coil drive signals from said actuator base (20) to said platform (30).

Air classifier

Method and apparatus for multiple document detection using ultrasonic phase shift amplitude

According to one aspect of the present invention an apparatus for multiple document detection includes an ultrasonic transmitter ( 14 ) for transmitting an ultrasonic signal ( 16 ). An ultrasonic receiver ( 20 ) receives the ultrasonic signal ( 17 ), after it passes through the at least one of the multiple documents ( 18 ). A phase comparator ( 24 ) compares the transmitted ultrasonic signal ( 16 ) and the received ultrasonic signal ( 17 ), and an amplitude measurement circuit ( 26 ) compares the received ultrasonic signal ( 17 ) to a reference. A microprocessor ( 32 ) compares an information signal ( 28 ) from the phase comparator ( 24 ) and an information signal ( 30 ) from the amplitude measurement circuit ( 26 ) to a predetermined threshold to determine if multiple documents are present.

Adjustable shelving

Bearing

Apparatus for transferring freight

Concentrator

Dust extractor

Dynamic copy window control for domain expansion reading

Process for producing ultra-high molecular weight low modulus polyethylene shaped articles via controlled pressure and temperature and compositions and articles produced therefrom

Shaped articles made from molded ultra high molecular weight polyethylene (UHMWPE) with an average molecular weight of between about 1 million and about 10 million and exhibiting a low modulus of elasticity throughout the shaped article or in selected regions of the shaped article are disclosed. These articles are produced by filling a mold with powdered UHMWPE, covering the mold with a piston, raising the temperature of the mold and its contents to between about 140° and about 225° C. while simultaneously applying a pressure of between about 2.5 and about 15 MPa to the mold and its contents, maintaining the pressure and temperature for between about 5 and about 25 minutes, with the time selected dependent upon the thickness of the molded part, then dropping the temperature of the molded part, either completely or in part at a rate between about 4° and about 175° C./minute either while maintaining the mold at the molding pressure, at pressure less than the molding pressure or under no external applied pressure. The shaped articles so produced exhibit a combination of properties including an elastic modules between about 500 MPA and about 800 MPA, a yield strength equal to or greater than about 20 Mpa, an elongation to rupture of greater than about 300%, crystallinity and density less than or equal to about that of the native powdered UHMWPE used to form the part and a melting point less than or equal to about that of native UHMWPE powder that has experienced melting and cooling at ambient pressure. The shaped articles are useful as the bearing surface of total knee joints, prosthetic hip joint cups and as other prosthetic shapes for replacement of other joints of the human body.

Method and apparatus for femoral resection

An instrument is provided for use in shaping a femur preparatory to implantation of a knee prosthesis. A gap checking device (40) is fixed to the distal end of the patient's femur and referenced to the epicondyles of the femur. The gap checking device (40) includes slots (70, 72, 74, 76, 78) through which a cutting instrument can be passed to shape the femur so that it can receive the femoral component of the prosthesis. One of the slots (70) enables the distal femoral cut to be made. The thickness of the gap setting device (40) is selected so that the distance between the distal femoral cut and the distal surface of the gap setting device plus the thickness of a shim resting on the cut proximal tibial surface is equal to the combined thickness of the tibial and femoral components of the prosthesis. This enables the flexion and extension gaps to be checked before the femoral cuts are made. The epicondyles can be located using intramedullary or extramedullary referencing. A special extramedullary locating device (10) is also described which is referenced to the trochlear groove of the femur and enables the placement of pins (38) in the epicondyles so that the gap checking device (40) can be properly situated with respect to the femur.

Multi-compartment device with magnetic particles

The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles.

Joint replacement spacers

Devices and methods are disclosed for joint replacement.

Spatially co-registered genomic and imaging (scorgi) data elements for fingerprinting microdomains

A method of generating a plurality of spatially co-registered data elements, each spatially co-registered data element being associated with and generated from a pair of co-registered tissue sections obtained from adjacent positions of a core taken from a tissue sample and including an image data section and a genomic data section. The method includes, for each pair of co-registered tissue sections: (i) obtaining and storing as part of a data element a plurality of multi to hyperplexed images from the imaging data section of the co-registered tissue section, (ii) generating and storing as part of the data element image data from the plurality of multi to hyperplexed images, and (iii) generating and storing as part of the data element genomic data from the genomic data section of the associated co-registered tissue section.

Presser-foot.

Dynamic copy window control for domain expansion reading

Method and apparatus for reading a magneto-optical domain expansion recording medium (10), wherein the size of a spatial copy window of a domain copying process is controlled by varying a predetermined reading parameter in response to a control information derived from a readout pulse. A predetermined additional pattern of change is applied to said predetermined parameter and the control information is then derived from a deviation of a clock signal. The size of the copy window can thus be controlled dynamically to obtain a robust and reliable readout process.

High frequency transmission system

Thread-controlling mechanism for sewing machines

Posteriorly stabilized total knee joint prosthesis

ABSTRACT OF THE DISCLOSURE A box-like recess between the condylar portions of the femoral component has a transverse convexly curved cam follower portion at the posterior extremity of a superior wall which engages a concave cam surface at the inferior portion of the posterior surface of a tibial post that extends up from the plateau surface of the tibial component into the recess. The camming action between the cam follower and cam surface forces the zones of contact between the condylar portions of the femoral component and concavities in the tibial component posteriorly as the leg approaches full flexion, thereby increasing the range of flexion without interference between posterior surfaces of the femur and the tibial component and preventing anterior dislocation of the femur. The plateau of the tibial component slopes inferiorly and posteriorly, also to increase the range of flexion without interference.

Process and material for treating gasoline and hydrocarbons

Resilient device

A system for cell-based screening

The present invention provides systems, methods, screens, and kits for optic al system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for those that specifically affect particular biological functions. The invention involves providing cel ls containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a high magnification fluorescence optical system, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in t he cells. The array of locations may be an industry standard 96 well or 384 wel l microtiter plate or a microplate which is a microplate having cells in a micropatterned array of locations. The invention includes apparatus and computerized method for processing, displaying and storing the data.

Freezing thermostat and control mechanism

Intramedullary rod

Method for automated tissue analysis

The invention provides an improved method for identifying and interpreting tissue specimens and/or cells derived from tissue specimens. A panel of cell-based reagents provides a number of readouts of cellular states or biomarkers that together define a profile of a diversity of cellular states or biomarkers in a tissue specimen representing the 'systems' nature of biology. This cellular profile is interpreted using informatics tools, to identify similarities between specimens, in vivo medical conditions, and suggest options for treating medical conditions.

Control of induction-motors.

Composition comprising a polyvinyl acetal, a phenol-aldehyde resin, a melamine-aldehyde resin adn a polyurethane, process for preparing same, and electrical conductor coa

Hip joint prosthesis with reduced stem stress

Vending machine

pH-change sensor and method

pH-change sensors and related methods are disclosed. One such sensor may have a first ion-sensitive transistor-operational-transconductance-amplifier (the “first IOTA”) and a second ion-sensitive transistor-operational-transconductance-amplifier (the “second IOTA”). Each IOTA may have an ion-sensitive transistor, a load transistor, and an output. In each IOTA, the drain region of the ion-sensitive transistor may be connected to the drain region of the load transistor. A differential sensor may be connected to the IOTAs, and an output from the differential sensor may indicate a voltage difference between the IOTA outputs. The output from the differential sensor may be used to provide an indication of a change in pH.

Methods and systems for detecting

A system and method is described wherein components of the reagent (4), e.g. labelled antibodies, are separated from the biologically active sensor surface (5) by depositing the reagent (4) on a carrier surface (3) distinct from the sensor surface (5) in the detection region (2), e.g. detection chamber. In this way, a high assay reproducibility is obtained. By allowing a short, well-defined and controlled, pre-incubation time between the particles of interest, e.g. drugs, in the sample fluid (20) and the reagent (4), the reproducibility will be increased, whereas the speed of the assay is guaranteed by having all components in one detection region (2), e.g. detection chamber.

Air classifier

Transmission mechanism

Feeding mechanism for sewing-machines.

Method and apparatus for a network connected storage system

A Data Storage Device (DSD) includes a Non-Volatile Memory (NVM) for storing data, a network interface for communicating on a network, and a processor. According to one aspect, a command is received via the network interface for storing data in the NVM or retrieving data from the NVM. Based on a transport attribute of the command, it is determined whether to execute a file interface for accessing files stored in the NVM or an object interface for accessing data objects stored in the NVM. According to another aspect, computer-executable instructions are received from a device via the network interface and the computer-executable instructions are executed using an off-load interface. The computer-executable instructions cause the processor to transform data stored in the NVM or data received from the network and send the transformed data to another device on the network or store the transformed data in the NVM.

Sewing-machine attachment.

Cyclone classifier

Apparatus for making hollow rubber articles

Process of coating a substrate with a polymeric ultraviolet light barrier coating and the coated substrate

Adjustment device for a carburetor

Method for diagnosis of physiological states by detecting patterns of volatile analytes

Provided is a non-invasive method for identification of non-physiological, physiological or diseased states based on the volatiles in gas or biogas samples from individuals. The method uses a sensor array comprising a plurality of distinct sensors which differ from other sensors by the sensing molecules or the sol-gel holding material composition. In response to a combination of volatiles, a pattern of responses is generated which can be correlated to particular non-physiological, physiological or diseased state.

Folding, portable leisure chair

The invention relates to a folding, portable leisure chair, which for use as a canopied beach chair comprises a hood-type windbreak consisting of textile fabric and a folding supporting structure that is or can be fixed to two support rods in order to shield against the wind. The leisure chair is characterised in that despite its low weight and excellent portability, said chair provides good weather protection for the occupant.

Auxiliary power supply and timer arrangement for time registering multifunctional electric energy meters

47,689 AUXILIARY POWER SUPPLY AND TIMER ARRANGEMENT FOR TIME REGISTERING MULTIFUNCTIONAL ELECTRIC ENERGY METERS ABSTRACT OF THE DISCLOSURE A time based measuring system for electric energy meters includes a non-volatile data memory for processing time related data. The system further includes a main DC supply energized from an AC source and an auxiliary DC supply energized by a primary battery source. The data memory and a low power secondary timer circuit are energized from the auxiliary DC supply in response to failure of the main DC supply. A low power circuit arrangement including the secondary circuit continues current time and calendar registrations during a power outage.

Carburetor choking device

Clamping device

Feeding mechanism for sewing-machines.

Classifier

Street-car.

Low power glare sensor

The invention may be embodied as a glare detection system or as a method of detecting glare. In a system according to the invention, there may be a light receiving surface, a first input channel, a second input channel, a glare signaling circuit and a glare reducing circuit. The first input channel may provide an indication of the amount of light impinging on a first portion of the light receiving surface. The second input channel may provide an indication of the amount of light impinging on a second portion of the light receiving surface. The glare signaling circuit ("GSC") may have a first input port in communication with the first input channel, a second input port in communication with the second input channel, a logic-or gate capable of producing an output signal when the logic-or gate detects that the first input channel or the second input channel indicates glare on the light receiving surface. The glare reducing circuit ("GRC") may be in communication with the logic-or gate, and may be capable of reacting when the logic-or gate produces the output signal. For example, the GRC may react by determining where on the light receiving surface glare exists.

Device for testing a fluid

A device (1) for testing a fluid comprises an elongated carrier (3); two foam members (5a, 5b) for absorbing the fluid, which are arranged at an end (4) of the carrier (3); a positioning member (6) comprising a sleeve (7) which is slidably arranged on the carrier (3); and a diagnostic device (2), which is arranged in the positioning member (6), and which comprises a sensor die (40) adapted to detecting at least one property of the fluid and means for supplying the fluid to a sensitive surface of the sensor die (40). After the fluid has been supplied to the foam members (5 a, 5b), the positioning member (6) is moved towards the end (4) of the carrier (3) where the foam members (5a, 5b) are located. When the diagnostic device (2) comes into contact with one of the foam members (5a, 5b), the fluid is squeezed from the foam member (5a) and supplied to the sensitive surface of the sensor die (40), through the fluid supplying means of the diagnostic device (2).

Prosthetic knee joint

The present invention is directed to prosthetic knee joints having femoral and tibial components.