04-03-2021 дата публикации
Номер: US20210061784A1
Принадлежит:
Disclosed herein are compounds, compositions, and methods of their use for the treatment of diabetes. 119.-. (canceled)21. The method of claim 20 , wherein p is 1.22. The method of claim 21 , wherein n is 1 or 2.23. The method of claim 22 , wherein each Ris independently halogen or Calkyl.25. (canceled)26. The method of claim 24 , wherein Rand Rare each independently Calkyl.27. The method of claim 26 , wherein Rand Rare each —CH.28. (canceled)29. The method of claim 27 , wherein Ris heteroaryl and wherein heteroaryl is unsubstituted or substituted by one or more substituents selected from halogen claim 27 , Calkyl claim 27 , Calkoxy claim 27 , Chaloalkyl claim 27 , Chaloalkoxy claim 27 , —OH claim 27 , —CHOH claim 27 , —CN claim 27 , —COR claim 27 , Ccycloalkyl claim 27 , and phenyl.30. The method of claim 29 , wherein Ris unsubstituted pyridyl.31. The method of claim 29 , wherein Ris pyridyl substituted by one substituent selected from halogen claim 29 , Calkyl claim 29 , Calkoxy claim 29 , Chaloalkyl claim 29 , Chaloalkoxy claim 29 , —OH claim 29 , —CHOH claim 29 , —CN claim 29 , —COR claim 29 , Ccycloalkyl claim 29 , and phenyl.32. The method of claim 31 , wherein Ris pyridyl substituted by Calkyl.33. The method of claim 32 , wherein Ris pyridyl substituted by —CH.34. The method of claim 27 , wherein Ris aryl and wherein aryl is unsubstituted or substituted by one or more substituents selected from halogen claim 27 , Calkyl claim 27 , Calkoxy claim 27 , Chaloalkyl claim 27 , Chaloalkoxy claim 27 , —OH claim 27 , —CHOH claim 27 , —CN claim 27 , —COR claim 27 , Ccycloalkyl claim 27 , and phenyl.35. The method of claim 34 , wherein Ris unsubstituted phenyl.36. The method of claim 34 , wherein Ris phenyl and wherein phenyl is substituted by one substituent selected from halogen claim 34 , Calkyl claim 34 , Calkoxy claim 34 , Chaloalkyl claim 34 , Chaloalkoxy claim 34 , —OH claim 34 , —CHOH claim 34 , —CN claim 34 , —COR claim 34 , Ccycloalkyl claim 34 , and phenyl.37 ...
Подробнее