28-12-2017 дата публикации
Номер: US20170368017A1
The present invention relates to novel antibacterial compounds, pharmaceutical compositions containing them and their use as antimicrobials. 1: A compound of formula (I){'br': None, 'sub': 1', '2', '3, 'A-L-B-L-Y-L-C\u2003\u2003(I)'} A is a 10-membered fused bicyclic ring;', {'sub': 1', '1-3, 'Lis σ bond, —O— or —N(R′)—, wherein R′ is H or (C)alkyl;'}, 'B is a divalent residue of a piperazine or piperidine ring;', {'sub': 2', '2', '1-3, 'Lis σ bond, —CH—, —O—, or —N(R′)—, wherein R′ is H or (C)alkyl;'}, {'sub': 1-6', '2-6', '2-6', '3-6', '1-3', '3-6', '1-3, 'Y is a (C)alkylenyl, (C)alkenylenyl, (C)alkynylenyl, or (C)cycloalkylenyl group, said group being optionally substituted with one or more groups selected from —OH, (C)alkyl, (C)cycloalkyl, 3- to 5-membered oxacycloalkyl, —COOR′, —NR′R″ wherein R′ and R″, identical or different each other, are hydrogen atom or (C)alkyl,'}, {'sub': 3', '2', '2', '1-6', '1-6', '2', '2', '1-3, 'Lis —O—, —(CH)—, —N(R′)—, —N(R′)—C(═O)—, —N(R′)—C(═S)—, —N(R′)—(C)alkylenyl-, —C(═O)—N(R′)—, —C(═O)—N(R′)—(C)alkylenyl-, —SO—N(R′)—, —N(R′)—SO—, wherein R′ is hydrogen atom or (C)alkyl;'}, 'C is a group having a 5- or 6-membered saturated or unsaturated ring, or a 9- or 10-membered fused bicyclic ring;', 'or an addition salt with a pharmaceutically acceptable organic or inorganic acid or base, an enantiomer, N-oxide, or quaternary ammonium salt of said compound of formula (I)., 'wherein'}5: The compound according to claim 4 , wherein Rand Rtogether form a ring selected from the group consisting of benzene claim 4 , furan claim 4 , tetrahydrofuran claim 4 , dioxolane claim 4 , piperidine and piperazine.6: The compound according to claim 4 , wherein Rand R claim 4 , equal or different each other claim 4 , are a hydrogen atom or an aryl group claim 4 , or together form a ring selected from the group consisting of benzene claim 4 , pyridine claim 4 , and piperidine.8: The compound according to claim 1 , wherein said Y is a (C)alkylenyl claim 1 , ...
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