Inhibition of reactive oxygen species and protection of mammalian cells

Water electrolysis apparatus for producing hydrogen gas as auxiliary fuel for engine by low current

The invention provides a water electrolysis device in low current for producing hydrogen used as an auxiliary fuel of an engine. The water electrolysis device comprises a set of positive and negative electrode plates arranged in a water electrolyser. The electrode plates with the same polarity are connected by an electrical conductor. The electrode plates with the opposite polarity are separated by an insulator. The positive and negative electrode plates are alternately arranged and connected by positive and negative electrode bars in a penetrating way. The positive and negative electrode bars are connected with electrolysis electric supply. One of the positive and negative electrode plates is the mesh structure and the other electrode plate is plate shaped. The electrical conductor is stainless steel. The insulator is high temperature resistance nylon materials. The water electrolysis device has the beneficial effects that by the unique structure and size design, the electrolysis device ...

Water electrolysis apparatus for producing hydrogen gas as auxiliary fuel for engine by low current

The invention provides a water electrolysis device in low current for producing hydrogen used as an auxiliary fuel of an engine. The water electrolysis device comprises a set of positive and negative electrode plates arranged in a water electrolyser. The electrode plates with the same polarity are connected by an electrical conductor. The electrode plates with the opposite polarity are separated by an insulator. The positive and negative electrode plates are alternately arranged and connected by positive and negative electrode bars in a penetrating way. The positive and negative electrode bars are connected with electrolysis electric supply. One of the positive and negative electrode plates is the mesh structure and the other electrode plate is plate shaped. The electrical conductor is stainless steel. The insulator is high temperature resistance nylon materials. The water electrolysis device has the beneficial effects that by the unique structure and size design, the electrolysis device ...

Tyre pressure detecting system

The invention discloses a tyre pressure detecting system. A technical proposal of the invention is that the tyre pressure detecting system comprises a tyre pressure cap and a main display capable of performing wireless communication with the tyre pressure cap, and is characterized in that: the tyre pressure detecting system also comprises a GSM or CDMA network receiving terminal capable of performing wireless communication with the main display. The main display can perform wireless communication with the tyre pressure cap and the GSM or CDMA network receiving terminal; the tyre pressure cap sends tyre pressure data to the main display in a wireless communication mode so as to bring convenience to a user to observe the tyre pressure data in real time in the driving process; and the wireless communication between the main display and the GSM or CDMA network receiving terminal can send the tyre pressure data to the GSM or CDMA network receiving terminal such as a mobile phone of the user ...

Tyre pressure detecting system

The invention discloses a tyre pressure detecting system. A technical proposal of the invention is that the tyre pressure detecting system comprises a tyre pressure cap and a main display capable of performing wireless communication with the tyre pressure cap, and is characterized in that: the tyre pressure detecting system also comprises a GSM or CDMA network receiving terminal capable of performing wireless communication with the main display. The main display can perform wireless communication with the tyre pressure cap and the GSM or CDMA network receiving terminal; the tyre pressure cap sends tyre pressure data to the main display in a wireless communication mode so as to bring convenience to a user to observe the tyre pressure data in real time in the driving process; and the wireless communication between the main display and the GSM or CDMA network receiving terminal can send the tyre pressure data to the GSM or CDMA network receiving terminal such as a mobile phone of the user ...

Web-Based Operator Control Interface to Generator Control Systems

A web-based operator control interface system can include an operator interface section including a web browser application, a generator exciter section or a static starter section coupled to the operator interface section, a generator coupled to the generator exciter section and a web server application configured to receive processing requests from the web browser application, and further configured to internally process real-time generator functions.

METHODS AND COMPOSITIONS FOR THE PREPARATION OF AEROSOLS

The present invention relates to methods for the preparation of an aerosol. More specifically the present invention provides methods for the preparation of an aerosol of immunoglobulin single variable domains wherein the amount of aggregate formation is significantly reduced. The invention further provides aerosols prepared by the methods of the invention, as well as compositions for use in the methods of the invention. The invention further relates to methods for the preparations of such compositions, to containers, kits and aerosol delivery systems comprising such compositions and to uses of the same. 1. Method for the preparation of an aerosol of immunoglobulin single variable domains wherein the amount of aggregate formation is 6% or lower , the % of aggregate formation as determined by SE-HPLC , said method comprising the step of atomizing a composition comprising an aqueous carrier and a polypeptide comprising one or more immunoglobulin single variable domains , wherein:the composition further comprises a surfactant at a concentration between 0.001% and 1%; and/orthe polypeptide comprising one or more immunoglobulin single variable domains is present in the composition at a concentration of 50 mg/mL to 200 mg/mL; and/orthe composition is atomized in a vibrating-mesh nebulizer.2. Method of claim 1 , wherein the composition further comprises a surfactant at a concentration between 0.001% and 1% claim 1 , or between 0.001% to about 0.1% claim 1 , or about 0.01% to about 0.1% or about 0.001% claim 1 , 0.005% claim 1 , 0.01% claim 1 , 0.02% claim 1 , 0.05% claim 1 , 0.08% or 0.1%.3. Method of claim 1 , wherein the surfactant is selected from polysorbates claim 1 , optionally Tween 20 or Tween 80 claim 1 , and poloxamers claim 1 , or wherein PEG is added as a surfactant-like compound.4. Method of claim 2 , wherein the polypeptide comprising one or more immunoglobulin single variable domains is present at a concentration of lower than 20 mg/mL.5. Method of claim 1 , ...

COMPOSITIONS AND METHODS FOR TREATING HEPATITIS C VIRUS

Disclosed herein are a composition and unit dosage form for the treatment of hepatitis C virus (HCV) infection comprising GS-7977 and at least one pharmaceutically acceptable excipient, as well as methods for making said composition and unit dosage form. Also disclosed herein is a method of treating a subject, preferably a human, infected with hepatitis C virus, said method comprising administering to the subject for a time period an effective amount of GS-7977 and an effective amount of ribavirin. In one aspect, the method comprises administering to the subject an interferon-free treatment regimen comprising an effective amount of GS-7977 and an effective amount of ribavirin. In a particular aspect, the method is sufficient to produce an undetectable amount of HCV RNA in the subject for at least 12 weeks after the end of the time period. 1. A pharmaceutical composition comprising:a) about 25% to about 35% w/w of GS-7977; andb) at least one pharmaceutically acceptable excipient.2. The composition according to claim 1 , wherein the composition comprises about 30% to about 35% w/w of GS-7977.3. The composition according to claim 1 , wherein the composition comprises about 30% w/w of GS-7977.4. The composition according to claim 1 , wherein the composition comprises about 33% w/w of GS-7977.5. The composition according to claim 1 , wherein the composition comprises crystalline GS-7977.6. The composition according to claim 5 , wherein the crystalline GS-7977 has XRPD 2θ-reflections (°) at about:(1) 5.2, 7.5, 9.6, 16.7, 18.3, and 22.2;(2) 5.0, 7.3, 9.4, and 18.1;(3) 4.9, 6.9, 9.8, 19.8, 20.6, 24.7, and 26.1;(4) 6.9, 9.8, 19.7, 20.6, and 24.6;(5) 5.0, 6.8, 19.9, 20.6, 20.9, and 24.9;(6) 5.2, 6.6, 7.1, 15.7, 19.1, and 25.0; or(7) 6.1, 8.2, 10.4, 12.7, 17.2, 17.7, 18.0, 18.8, 19.4, 19.8, 20.1, 20.8, 21.8, and 23.3.7. The composition according to claim 6 , wherein the crystalline GS-7977 has XRPD 2θ-reflections (°) at about:(1) 5.0, 7.3, 9.4, and 18.1; or(2) 6.1, 8.2, 10.4, ...

MOBILE MESSAGING ECOSYSTEM - RENDERED MESSAGE

This disclosure relates to the use of a content message layer or a mobile device edge technology to render and measure interactive impression messages to a mobile device during a specified time and place and with discretionary control. Furthermore, the disclosure describes a new mobile message delivery and measurement channel that joins the message sender and recipient in a closed-loop progressive conversation and where messages can be rolled over in time. 1. An apparatus comprising: a mobile device having a processing device and memory device , the mobile device configured to repurpose the lock screen display of the mobile device to use the firmware , hardware , software , and related operating system components of the mobile device to render an advertisement or alert message on the lock screen display during the period between wake-up of the mobile device and unlocking of the mobile device , and that allows a user of the mobile device to interact with the advertisement or alert message using the firmware , hardware , software , and related operating system of the mobile device.2. The apparatus of wherein the mobile device receives and stores an advertisement or alert message.3. The apparatus of wherein the mobile device user can cause the advertisement or alert message being rendered on the lock screen display to be accompanied by vibration of the mobile device.4. The apparatus of wherein the mobile device user can cause the advertisement or alert message already rendered on the lock screen display to be accompanied by vibration of the mobile device.5. The apparatus of wherein the mobile device user can cause the advertisement or alert message being rendered on the lock screen display to rotate with the mobile device.6. The apparatus of wherein the mobile device user can cause the advertisement or alert message already rendered on the lock screen display to rotate with the mobile device.7. The apparatus of wherein the mobile device user can cause the advertisement ...

RECOMMENDATION MACHINE

A machine may be configured as a recommendation machine that makes one or more recommendations to one or more users. The machine may provide a recommendation based on one or more psychometric profiles that correspond to a user, a product, a manager for the product, or any suitable combination thereof. The user may be a potential buyer of the product, and the manager for the product may fully or partially manage the product and consequently affect the value of the product. The user's psychometric profile may describe market understanding and risk tolerance possessed by the user, and the manager's psychometric profile may describe market understanding and risk tolerance held by the manager. Such psychometric profiles may be used to make recommendations of products. In addition, a psychometric profile for the product itself may be used in the making of such recommendations. 1. A method comprising: the first psychometric profile including a market model of the user and a risk model of the user,', 'the market model of the user indicating an unconscious characterization applied by the user to a market for products,', 'the risk model of the user indicating an unconscious degree of risk tolerable by the user;, 'accessing a first psychometric profile of a user,'} 'a second psychometric profile among the plurality of psychometric profiles being correlated with a product within the market to which the unconscious characterization is applied;', 'accessing a plurality of psychometric profiles of products within the market,'}using a processor, identifying the product based on a comparison of the first psychometric profile of the user to the second psychometric profile correlated to the product; andcausing a user interface to present the user with a reference to the product in response to the identifying of the product based on the comparison of the first and second psychometric profiles.2. The method of further comprising: the generating of the first psychometric profile ...

Variable Coupler Drive

The inventive technology described herein generally relates to the field of power transmission, more particularly power transmission through a mechanical drive system. More specifically, in certain embodiments the inventive technology includes methods and apparatus for a variable coupler drive utilizing, in one embodiment a dynamic drive-ratio gearing system to transmit a drive input for application with a variety of output uses. In a preferred embodiment, such a variable coupler drive may be used to transmit a rotational drive input to a drive shaft to power, for example, a variety of commercial and industrial applications, and may be particularity suited to power rotational propeller based propulsion systems.

FORMULATION OF SYK INHIBITORS

Disclosed are pharmaceutical compositions comprising a compound having the formula: 139-. (canceled)41. The method of claim 40 , wherein the methanesulfonic acid or an anion thereof claim 40 , and the compound of Formula I or a cation thereof claim 40 , are present in the feed solution in a molar ratio of the methanesulfonic acid or an anion thereof claim 40 , to the compound of Formula I or a cation thereof claim 40 , of between 2:1 and 3:1.42. The method of claim 40 , wherein the mesylate salt of the compound of Formula I is a bis-mesylate salt of the compound of Formula I claim 40 , or a hydrate thereof.43. The method of claim 40 , wherein the mesylate salt is a monohydrate claim 40 , bis-mesylate salt of the compound of Formula I.4550-. (canceled)52. The method of claim 51 , wherein the condition is selected from the group consisting of acute lymphocytic leukemia (ALL) claim 51 , acute myeloid leukemia (AML) claim 51 , chronic lymphocytic leukemia (CLL) claim 51 , small lymphocytic lymphoma (SLL) claim 51 , myelodysplastic syndrome (MDS) claim 51 , myeloproliferative disease (MPD) claim 51 , chronic myeloid leukemia (CML) claim 51 , multiple myeloma (MM) claim 51 , non-Hodgkin's lymphoma (NHL) claim 51 , mantle cell lymphoma (MCL) claim 51 , follicular lymphoma (FL) claim 51 , Waldestrom's macroglobulinemia (WM) claim 51 , T-cell lymphoma claim 51 , B-cell lymphoma claim 51 , diffuse large B-cell lymphoma (DLBCL) claim 51 , lymphoplasmacytic lymphoma (LPL) claim 51 , and marginal zone lymphoma (MZL).53. The method of claim 52 , wherein the condition is non-Hodgkin's lymphoma (NHL).54. The method of claim 53 , wherein the NHL is indolent non-Hodgkin's lymphoma (iNHL).55. The method of claim 54 , wherein the iNHL is refractory iNHL.56. The method of claim 54 , wherein the iNHL is non-FL iNHL.57. The method of claim 51 , wherein the condition is selected from the group consisting of asthma claim 51 , rheumatoid arthritis claim 51 , multiple sclerosis claim 51 , and ...

FIRST PARTY ADVERTISEMENT SERVING

Adservers with the ability to access advertiser cookies and vice versa when both are serving from the advertiser's domain are provided, thereby avoiding the overhead and delay in backend cookie synchronization efforts. Further, advertising cookie data can be gathered regardless of whether a user is browsing a publisher's web site with an advertisement served by an adserver, or browsing the advertiser's web site, because the cookies were previously set when the user visited the advertiser's web site in the context of a first-party cookie. Even if the user has configured his or her browser to limit the setting of third-party cookies, the cookies can still be read by the adserver. By making cookie and advertising data immediately available in real time to both the advertiser and the adserver, the solution also provides for instantaneous and accurate targeting of web advertising to allow an educated ad selection process by either party. 1. A method for serving advertisements , the method comprising:establishing a virgin domain;configuring a computer system to act as an origin server within the virgin domain; setting the origin server to serve web content without using cookies; andserving advertisements from within the virgin domain.2. The method of further comprising detecting a cookie from a browser through the virgin domain and taking a corrective action to restore a status of the virgin domain.3. The method of wherein the corrective action comprises deleting the cookie detected from the browser.4. The method of wherein the corrective action comprises expiring the cookie detected from the browser.5. The method of further comprising detecting a cookie from a browser through the virgin domain and providing an alert in response to detecting the cookie from the browser.6. The method of further comprising removing the virgin domain from a database of virgin domains.7. The method of further comprising detecting cookies from a browser through the virgin domain and ...

METAL DETECTION SYSTEMS AND METHODS

A metal detection device for detecting metal within notes being placed into a note recycler and handling machine includes a note guide having a note passage. The note passage has a first side and a second side. A first printed circuit board (PCB) is disposed within the first side of the note passage of the note guide. The first PCB includes a substrate and a planar metallic coil deposited on the substrate. A second PCB is disposed within the second side of the note passage of the note guide. The second PCB includes a substrate and a planar metallic coil deposited on the substrate. 1. A metal detection device for detecting metal within notes being placed into a note recycler and handling machine comprising:a note guide having a note passage, the note passage having a first side and a second side; a substrate; and', 'a planar metallic coil deposited on the substrate; and, 'a first printed circuit board (PCB) disposed within the first side of the note passage of the note guide, the first PCB including a substrate; and', 'a planar metallic coil deposited on the substrate., 'a second PCB disposed within the second side of the note passage of the note guide, the second PCB including2. The metal detection device of claim 1 , wherein the first PCB and the second PCB are parallel to one another.3. The metal detection device of claim 1 , wherein the metallic coil of the first PCB and the metallic coil of the second PCB face one another.4. The metal detection device of claim 1 , wherein at least one of the metallic coils is a rectangular shaped coil.5. The metal detection device of claim 1 , wherein at least one of the metallic coils includes 15 turns.6. The metal detection device of claim 1 , wherein at least one of the metallic coils is formed by a metallic trace arranged in a series of inwardly winding loops claim 1 , wherein adjacent loops of the metallic coil are spaced apart from one another by 0.008 inches.7. The metal detection device of claim 6 , wherein the metallic ...

FORMULATION OF SYK INHIBITORS

Disclosed are pharmaceutical compositions comprising a compound having the formula: 2. The composition of claim 1 , wherein the bis-mesylate salt is a monohydrate claim 1 , bis-mesylate salt of the compound of Formula I.3. The composition of claim 1 , wherein the bis-mesylate salt is a polymorph having an X-ray diffraction pattern comprising 2θ-reflections claim 1 , plus or minus 0.2 degrees 2θ claim 1 , at 7.7 claim 1 , 12.9 claim 1 , 17.7 claim 1 , and 18.1.4. The composition of claim 3 , wherein the bis-mesylate salt is a polymorph having an X-ray diffraction pattern further comprising 2θ-reflections claim 3 , plus or minus 0.2 degrees 2θ claim 3 , at 13.8 claim 3 , 16.9 claim 3 , 22.9 and 26.1.5. The composition of claim 1 , further comprising methanesulfonic acid.6. The composition of claim 1 , wherein the at least one pharmaceutically acceptable carrier is at least one pharmaceutically acceptable polymer.7. The composition of claim 6 , wherein the at least one pharmaceutically acceptable polymer is a precipitation inhibitor.8. The composition of claim 6 , wherein the at least one pharmaceutically acceptable polymer is non-ionic.9. The composition of claim 6 , wherein the at least one pharmaceutically acceptable polymer is selected from the group consisting of hydroxypropylmethylcellulose claim 6 , copovidone claim 6 , povidone claim 6 , methyl cellulose claim 6 , hydroxyethylcellulose claim 6 , hydroxypropylcellulose claim 6 , ethylcellulose claim 6 , pyroxylin claim 6 , polyethylene oxide claim 6 , polyvinyl alcohol claim 6 , polyethylene glycol claim 6 , and polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol.10. The composition of claim 9 , wherein the at least one pharmaceutically acceptable polymer is hydroxypropylmethylcellulose.11. The composition of claim 6 , wherein the composition comprises a polymer matrix obtainable from the at least one pharmaceutically acceptable polymer.12. The composition of claim 11 , wherein the compound of Formula I ...

Operating method of an iron making installation and associated operating installation

A method of operating an iron making installation is provided, in which waste material is dried using a drying gas, the drying gas including an exhaust gas from a sinter plant, and the dried material is roasted a roasting gas, so as to produce coal and a roasting exhaust gas. An associated installation is also provided. 120-. (canceled)21. A method of operating of an iron making installation , the method comprising the steps of:drying waste material using a drying gas, the drying gas comprising an exhaust gas from a sinter plant, androasting the dried waste material using a roasting gas, so as to produce coal and a roasting exhaust gas.22. The operating method according to claim 21 , wherein the drying gas comprises at least 50% of an exhaust gas from a sinter plant.23. The operating method according to claim 21 , further comprising recycling at least a part of the roasting exhaust gas to the sinter plant.24. The operating method according to claim 21 , wherein the drying gas has a temperature of at least 70° C.25. The operating method according to wherein the sinter plant exhaust gas is mixed with other components to form the drying gas claim 22 , and has a temperature between 100 and 150° C. when mixed with the other components to form the drying gas.26. The operating method according to claim 21 , wherein the roasting is performed at a temperature between 200 and 320° C.27. The operating method according to claim 21 , wherein at least a part of the roasting exhaust gas is used as part of the drying gas.28. The operating method according to claim 21 , wherein the roasting exhausts gas is used in the roasting step as part of the roasting gas.29. The operating method according to claim 21 , wherein after the roasting step the coal is used as raw material into an iron making process.30. The operating method according to claim 29 , wherein after the roasting step the coal is subjected to a milling step and milled coal is injected into a blast furnace through a tuyere. ...

Processes using improved rho adsorbent compositions

Disclosed herein are new processes for adsorbing oxygen using adsorbent compositions comprising RHO zeolites kinetically selective for oxygen. The RHO zeolites can be used in pressure swing adsorption processes for separating oxygen from oxygen containing streams, such as for, but not limited to, purifying a crude argon feed stream or separating oxygen from an air feed stream.

RHO ADSORBENT COMPOSITIONS, METHODS OF MAKING AND USING THEM

Disclosed herein are novel RHO zeolites useful as kinetically selective adsorbents for oxygen and/or nitrogen. The adsorbents can be used in pressure swing adsorption processes for selectively adsorbing oxygen and/or nitrogen from feed streams such as an air stream or crude argon stream. Also disclosed are novel methods of preparing RHO zeolites, including in particular mixed-cation RHO zeolites. 1. A RHO zeolite having a Si/Al ratio of from 3.2 to 4.5 and containing non-proton extra-framework cations , wherein the zeolite contains at most 1 proton per unit cell , and wherein the size , number and charge of the extra-framework cations that are present in the zeolite are such that 1 or fewer non-proton extra-framework cations per unit cell are required to occupy 8-ring sites.2. The zeolite of claim 1 , wherein the zeolite has a Si/Al ratio of from 3.6 to 4.2.3. The zeolite of claim 1 , wherein the non-proton extra-framework cations comprise Li claim 1 , Mg claim 1 , Mn claim 1 , Fe claim 1 , Co claim 1 , Ni claim 1 , Cu and/or Zn cations.4. The zeolite of claim 1 , wherein the non-proton extra-framework cations comprise Li and/or Zn cations.5. The zeolite of claim 4 , wherein said Land/or Zn cations make up the majority of the extra-framework cations that are present per unit cell.6. The zeolite of claim 4 , wherein said Land/or Zn cations make up at least 70% of the extra-framework cations that are present per unit cell.7. The zeolite of wherein said Land/or Zn cations make up at least 80% of the extra-framework cations that are present per unit cell.8. The zeolite of claim 1 , wherein the zeolite has a unit cell axis length of from 14.23 Å to 14.55 Å.9. The zeolite of claim 1 , wherein the zeolite has a unit cell axis length of from 14.23 Å to 14.50 Å.10. The zeolite of claim 1 , wherein the zeolite has a unit cell axis length of from 14.30 Å to 14.45 Å.11. The zeolite of claim 8 , wherein the zeolite is selected from LiZnRHO(3.9) claim 8 , LiZnHNaRHO(3.9) claim 8 ...

Locating loose connections in an electrical circuit

An electrical system includes an electrical circuit having a plurality of current paths and a plurality of switches for directing current to the plurality of current paths. A sensor senses a current or voltage in the electrical circuit. A processor connected to the sensor receives sensor data corresponding to the current or voltage in the circuit. The processor is configured to determine a location of a loose connection in the electrical circuit based on the current or voltage data and a switching sequence of the plurality of switches.

Nanobody dimers linked via c-terminally engineered cysteins

The present invention relates to dimers comprising a first polypeptide and a second polypeptide, wherein each of said first and second polypeptide comprises at least one immunoglobulin single variable domain (ISVD) and a C-terminal extension comprising a cysteine moiety (preferably at the C-terminus), wherein said first polypeptide and said second polypeptide are covalently linked via a disulfide bond between the cysteine moiety of said first polypeptide and the cysteine moiety of said second polypeptide, in which the dimer outperformed the benchmark constructs, e.g. cognate multivalent and multispecific constructs, in various assays. The present invention provides methods for making the dimers of the invention.

CLEANING FORMULATIONS

A composition and method for removing copper-containing post-etch and/or post-ash residue from patterned micro-electronic devices is described. The removal composition includes water, a fluoride ion source, an alkanolamine, sulfuric acid, and an organic acid. The compositions effectively remove the copper and cobalt-containing post-etch residue from the microelectronic device without damaging exposed low-k dielectric and metal interconnect materials. 1. A composition useful for removing residue from a semiconductor substrate , the composition comprising:from about 25% to about 80% by weight of water;from about 0.01% to about 5% by weight of a fluoride ion source, based on actives;from about 0.01% to about 10% by weight of sulfuric acid;from about 1% to about 50% by weight of an alkanolamine;from about 1% to about 25% by weight of an organic acid,wherein the pH of the composition is from 7 to 9.2. A composition useful for removing residue from a semiconductor substrate , the composition comprising:from about 50% to about 62.7% by weight of water;from about 9.5% to about 15% by weight of a source of fluoride ions, based on actives;from about 2.0% to about 8% by weight of sulfuric acid;from about 25% to about 30% by weight of an alkanolamine; andfrom about 0.8% to about 2.0% by weight of an organic acid.3. The composition of further comprising from about 0.1% to about 15% by weight of a corrosion inhibitor selected from the group consisting of benzotriazole claim 1 , o-tolyltriazole claim 1 , m-tolyltriazole claim 1 , p-tolyltriazole claim 1 , carboxybenzotriazole claim 1 , 1-hydroxybenzotriazole claim 1 , nitrobenzotriazole and dihydroxypropylbenzotriazole.4. The composition of further comprising a water-miscible organic solvent selected from the group consisting of propylene glycol claim 1 , glycerol claim 1 , dimethylacetamide claim 1 , tetrahydrofuryl alcohol claim 1 , ethylene glycol claim 1 , hexylene glycol claim 1 , and mixtures thereof.5. The composition of ...

TiN Hard Mask And Etch Residual Removal

Composition, method and system for PVD TiN hard mask removal from 28/20 nm pattern wafers have been disclosed. The composition uses peroxide as oxidizing agent for PVD TiN hard mask removal under slightly basic conditions. The composition comprises bulky or long chain organic amines or polyalkylamine to improve removal/etching selectivity of PVD TiN vs CVD TiN. The composition further comprises long chain organic acids or amines to maintain Co compatibility. 2. The composition of claim 1 , wherein the peroxide is selected from the group consisting of hydroxide peroxide claim 1 , ammonium persulfate claim 1 , peracidic acid claim 1 , peroxybenzoic acid claim 1 , and combinations thereof.3. The composition of claim 2 , wherein the peroxide is hydroxide peroxide.4. The composition of claim 1 , wherein the base is selected from the group consisting of tetraethylammonium hydroxide(TEAH) claim 1 , trimethylphenylammonium hydroxide claim 1 , tetramethylammonium hydroxide claim 1 , tetrabutylammonium hydroxide claim 1 , choline hydroxide claim 1 , ammonium hydroxide claim 1 , and combinations thereof.5. The composition of claim 4 , wherein the base is tetraethylammonium hydroxide.6. The composition of claim 1 , wherein the weak acid is carboxylic acid selected from the group consisting of citric acid claim 1 , oxalic acid claim 1 , malonic acid claim 1 , lactic acid claim 1 , adipic acid claim 1 , acetic acid claim 1 , iminodiacetic acid claim 1 , and combinations thereof.7. The composition of claim 6 , wherein the weak acid is citric acid.8. The composition of claim 1 , wherein the ammonium salt is selected from the group consisting of ammonium salts of weak bases and include ammonium citrate claim 1 , ammonium acetate claim 1 , ammonium malonate claim 1 , ammonium adipate claim 1 , ammonium lactate claim 1 , ammonium iminodiacetate claim 1 , ammonium chloride claim 1 , ammonium bromide claim 1 , ammonium fluoride claim 1 , ammonium bifluoride claim 1 , ammonium sulfate ...

RHO ZEOLITES AND METHOD OF MAKING THE SAME

Disclosed are novel, as-crystallized RHO zeolite compositions with improved uniformity in morphology. These RHO compositions are useful for preparing cation-exchanged RHO zeolites that can be used as adsorbents for oxygen and/or nitrogen with improved properties. The adsorbents can be used in pressure swing adsorption processes for selectively adsorbing oxygen and/or nitrogen from feed streams such as an air stream or crude argon stream. Also disclosed are novel methods of preparing RHO zeolites with improved morphology control. 1. An as-crystallized NaCsRHO zeolite having an Si/Al ratio of from 3.1 to 3.6 , wherein the zeolite has an Ocapacity of less than 0.015 mmol/g as measured by single point isotherm for O.2. The zeolite of claim 1 , wherein the zeolite has an Ocapacity of less than 0.010 mmol/g as measured by single point isotherm for O.3. The zeolite of claim 1 , wherein the zeolite has an Ocapacity of less than 0.005 mmol/g as measured by single point isotherm for O.4. A RHO zeolite formed from the as-crystallized NaCsRHO zeolite of by exchanging some or all of the Na and Cs cations present in the as-crystallized NaCsRHO zeolite with one or more other types of extra-framework cations.5. The RHO zeolite of claim 4 , wherein the zeolite contains non-proton extra-framework cations claim 4 , wherein the size claim 4 , number claim 4 , and charge of the extra-framework cations that are present in the zeolite are such that 1.8 or fewer non-proton extra-framework cations per unit cell are required to occupy 8-ring sites claim 4 , and wherein the zeolite has a unit cell axis length of from 14.23 Å to 14.55 Å.6. The RHO zeolite of claim 4 , wherein the zeolite contains at most 6 protons per unit cell.7. The RHO zeolite of claim 4 , wherein the RHO zeolite contains Li claim 4 , Mg claim 4 , Mn claim 4 , Fe claim 4 , Co claim 4 , Ni claim 4 , Cu and/or Zn cations.8. The RHO zeolite of claim 4 , wherein the RHO zeolite contains Li and/or Zn cations.9. The RHO zeolite ...

SYSTEM AND METHOD FOR TUNGSTEN HEXAFLUORIDE RECOVERY AND REUSE

Condensable materials, such as but not limited to tungsten fluoride (WF), can be used deposit films in a chemical vapor deposition (CVD) process. Described herein are methods to collect and reuse the condensable materials that are unreacted in the production process rather than treat these materials as waste. In one embodiment, when a condensable material, such as gaseous WF, is not supplied to the CVD reactor, it is redirected to a recovery cabinet for capture. 1. An apparatus for a recovery of a condensable material from a chemical process reactor that uses the condensable material , comprising;(a) a chemical process reactor provided with one or more lines for introducing the condensable material in electrical communication with a process controller;(b) an effluent line from the chemical process reactor capable of removing an unreacted condensable material introduced into the chemical process reactor;(c) a recovery line having a connection to the effluent line wherein the recover line is upstream of the check valve and wherein the recovery line and sends the unreacted condensable material from the effluent line and to a recovery vessel;(d) an automatic valve in the recovery line having a signal connection to the process controller;(e) a process controller; and,(f) the recovery vessel further comprising a cooling jacket in electrical communication with the process controller and capable of housing the unreacted condensable material.2. The apparatus of wherein the condensable material comprises WF.3. The apparatus of wherein the condensable material comprises an organosilane.4. The apparatus of wherein the condensable materials comprises an organometallic.5. The apparatus of wherein the recovery vessel which collects the condensable material further comprises KF as a complexing agent.6. The apparatus of wherein the recovery vessel comprises nickel.7. The apparatus of wherein the recovery vessel is comprised of a nickel-plated material. This application claims ...

COMPOSITIONS AND METHODS FOR TREATING HEPATITIS C VIRUS

Disclosed herein are a composition and unit dosage form for the treatment of hepatitis C virus (HCV) infection comprising GS-7977 and at least one pharmaceutically acceptable excipient, as well as methods for making said composition and unit dosage form. Also disclosed herein is a method of treating a subject, preferably a human, infected with hepatitis C virus, said method comprising administering to the subject for a time period an effective amount of GS-7977 and an effective amount of ribavirin. In one aspect, the method comprises administering to the subject an interferon-free treatment regimen comprising an effective amount of GS-7977 and an effective amount of ribavirin. In a particular aspect, the method is sufficient to produce an undetectable amount of HCV RNA in the subject for at least 12 weeks after the end of the time period. 150.-. (canceled)52. The method according to claim 51 , wherein the method comprises administering a daily dose of about 400 mg of the crystalline compound.53. The method according to claim 52 , wherein the method comprises administering a daily dose of about 1000 mg to about 1200 mg of ribavirin.54. The method according to claim 51 , wherein the method comprises administering the crystalline compound to the human once claim 51 , twice claim 51 , three times or four times daily.55. The method according to claim 51 , wherein the method comprises administering ribavirin to the human once claim 51 , twice claim 51 , three times or four times daily.56. The method according to claim 51 , wherein the method comprises administering the crystalline compound to the human once daily.57. The method according to claim 56 , wherein the method comprises administering ribavirin to the human twice daily.58. The method according to claim 51 , wherein the method comprises administering a daily dose of about 400 mg of the crystalline compound and a daily dose of about 1000 mg to about 1200 mg of ribavirin.59. The method according to claim 58 , ...

FORMULATION OF SYK INHIBITORS

Disclosed are pharmaceutical compositions comprising a compound having the formula: or a pharmaceutically acceptable salt thereof, or a hydrate of thereof, and at least one pharmaceutically acceptable polymer. The pharmaceutically acceptable salt of the compound of Formula I, or a hydrate thereof, can be a mesylate salt, including, for example, a mono-mesylate or a bis-mesylate salt, or a hydrate thereof. Also disclosed are methods of use for the pharmaceutical composition. 2. The composition of claim 1 , wherein the bis-mesylate salt is a monohydrate claim 1 , bis-mesylate salt of the compound of Formula I.3. The composition of or claim 1 , wherein the bis-mesylate salt is a polymorph having an X-ray diffraction pattern comprising 2θ-reflections claim 1 , plus or minus 0.2 degrees 2θ claim 1 , at 7.7 claim 1 , 12.9 claim 1 , 17.7 claim 1 , and 18.1.4. The composition of claim 3 , wherein the bis-mesylate salt is a polymorph having an X-ray diffraction pattern further comprising 2θ-reflections claim 3 , plus or minus 0.2 degrees 2θ claim 3 , at 13.8 claim 3 , 16.9 claim 3 , 22.9 and 26.1.5. The composition of any one of to claim 3 , further comprising methanesulfonic acid.7. The composition of claim 6 , wherein the methanesulfonic acid claim 6 , or an anion thereof claim 6 , and the compound of Formula I claim 6 , or a cation thereof claim 6 , are present in the composition in a molar ratio of the methanesulfonic acid claim 6 , or an anion thereof claim 6 , to the compound of Formula I claim 6 , or a cation thereof claim 6 , of between 2:1 and 3:1.8. The composition of any one of to claim 6 , wherein the at least one pharmaceutically acceptable carrier is at least one pharmaceutically acceptable polymer.9. The composition of claim 8 , wherein the at least one pharmaceutically acceptable polymer is a precipitation inhibitor.10. The composition of claim 8 , wherein the at least one pharmaceutically acceptable polymer is non-ionic.11. The composition of claim 8 , ...

TREATMENT FOR AORTIC ANEURYSMS

Compositions and methods for treatment of aortic disease in a subject in need comprising an effective amount of cobinamide. Aortic diseases include for example aortic aneurysm, aortic dissection, or aortic dilation. Aortic disease can be caused for example by Marfan syndrome or oxidative stress. 1. A method of treating an aortic disease in a subject comprising administering to a subject in need an effective amount of cobinamide , a cobinamide derivative , or a salt thereof.2. The method of claim 1 , wherein the aortic disease is aortic aneurysm claim 1 , aortic dissection claim 1 , or aortic dilation.3. The method of claim 1 , wherein the aortic disease is due to Marfan syndrome or thoracic aortic aneurysms and dissections (TAAD).4. The method of claim 1 , wherein a cobalt atom of the cobinamide claim 1 , cobinamide derivative claim 1 , or salt thereof independently may be coordinated with one or more ligands.5. The method of claim 1 , wherein the cobinamide claim 1 , cobinamide derivative claim 1 , or salt thereof is administered orally.6. A method of treating oxidative stress disease in a subject comprising administering to a subject in need an effective amount of cobinamide claim 1 , a cobinamide derivative claim 1 , or a salt thereof.7. The method of claim 6 , wherein the oxidative stress disease causes an aortic aneurysm claim 6 , aortic dissection claim 6 , or aortic dilation.8. The method of claim 6 , wherein the oxidative stress disease is due to Marfan syndrome or thoracic aortic aneurysms and dissections (TAAD).9. A method of treating aortic disease comprising administering to a subject in need an effective amount of a composition comprising an anti-oxidant to lower reactive oxygen species.10. The method of claim 9 , wherein the anti-oxidant is cobinamide claim 9 , a cobinamide derivative claim 9 , or a salt thereof.11. The method of claim 9 , wherein the method inhibits aortic dilation and SMC loss.12. The method of claim 9 , wherein the method inhibits ...

METHODS AND SYSTEMS FOR FINDING SIMILAR FUNDS

Systems and methods are presented for finding similar funds to a target fund in an investor's financial portfolio. In some embodiments, a method is presented. The method may include accessing target fund characteristics data describing former characteristics of a target fund. The method may also include accessing first comparison fund characteristics data describing present characteristics of a first comparison fund, accessing second comparison fund characteristics data describing present characteristics of a second comparison fund, generating a first difference metric indicating a measure of similarity between the former characteristics of the target fund and the present characteristics of the first comparison fund, generating a second difference metric indicating a measure of similarity between the former characteristics of the target fund and the present characteristics of the second comparison fund, ranking the first and the second difference metrics, and causing display of a visual presentation of the ranking by a graphical display. 1. A method comprising: target fund characteristics data of a target fund, the target fund characteristics data describing at least one former characteristic of the target fund;', 'first comparison fund characteristics data of a first comparison fund, the first comparison fund characteristics data describing at least one present characteristic of the first comparison fund;', 'second comparison fund characteristics data of a second comparison fund, the second comparison fund characteristics data describing at least one present characteristic about the second comparison fund;, 'accessing one or more databases includingcalculating, by one or more processors of a machine, a first difference metric between the target fund and the first comparison fund based on the target fund characteristics data and the first comparison fund characteristics data, the first difference metric indicating a measure of similarity between the at least one ...

METHODS AND SYSTEMS FOR DEPICTING PSYCHOLOGICAL ANALYSIS

Systems and methods are presented for providing a psychological analysis of financial products in an investor's financial portfolio. In some example embodiments, a method is presented. The method may include accessing, in a device comprising one or more processors, a psychometric data of a financial product, the psychometric data quantifying a decision-making tendency used in managing the financial product. The method may also include generating a psychological behavioral characteristic score of the financial product based on the accessed psychometric data, the psychological behavioral characteristic score indicating a degree to which the financial product exhibits a psychological characteristic relative to other financial products, generating an image of a graph that depicts the psychological behavioral characteristics score of the financial product relative to an axis that represents a range of degrees to which the psychological characteristic is exhibited by the other financial products, and causing display of the image of the graph. 1. A method comprising:accessing a database including psychometric data corresponding to a financial product, the psychometric data quantifying a decision-making tendency used in managing the financial product;calculating, by one or more processors of a machine, a psychological behavioral characteristic score associated with the financial product based on the accessed psychometric data, the psychological behavioral characteristic score indicating a degree to which the financial product exhibits a decision-making tendency relative to decision-making tendencies of other financial products;generating, by the one or more processors of the machine, an image of a graph that graphically depicts the psychological behavioral characteristics score corresponding to the financial product relative to an axis that represents a range of degrees to which the psychological characteristic is exhibited by the other financial products; andby the one or ...

Circuit Including a Switching Element, a Rectifying Element, and a Charge Storage Element

A circuit can include a pair of switching elements that have terminals electrically connected to terminals of a power supply and have other terminals electrically connected to an output terminal. The circuit can include rectifying elements and one or more charge storage elements. The circuit may be used as a Buck converter. The rectifying element(s) and charge storage element(s) may help to reduce ringing at an output terminal of the circuit during normal operation and reduce the likelihood of exceeding a breakdown voltage between current-carrying electrodes of a switching element within the circuit during a switching operation.

SOLID FORMS OF AN ANTIVIRAL COMPOUND

Crystalline solid forms of the anti-HCV compound (S)-isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate (Compound I) are described 2. The crystalline compound of claim 1 , wherein the XRPD spectrum further comprises a peak at 17.3 °2θ±0.2° 2θ.4. The crystalline compound of claim 3 , wherein the C SSNMR spectrum further comprises peaks at 21.5 claim 3 , 68.7 claim 3 , 81.7 claim 3 , 102.8 claim 3 , and 151 ppm±0.2 ppm.6. The crystalline compound of claim 5 , wherein the XRPD spectrum further comprises peaks at 14.2 claim 5 , 15.6 claim 5 , 16.0 claim 5 , 17.5 claim 5 , 18.1 claim 5 , 19.8 claim 5 , and 25.6 °2θ±0.2° 2θ.8. The crystalline compound of claim 7 , wherein the C SSNMR spectrum further comprises peaks at 22.2 claim 7 , 71.6 claim 7 , 78.8 claim 7 , 118.6 and 172.2 ppm±0.2 ppm.9. A pharmaceutical composition comprising the crystalline compound of and a pharmaceutically acceptable excipient.10. A method of treating a human subject infected with hepatitis C virus comprising administering to the human subject a therapeutically effective amount of the crystalline compound of . This application claims the benefits of U.S. Provisional Application No. 61/920,371, filed on Dec. 23, 2013, the entire disclosure of which is incorporated herein by reference.Hepatitis C is recognized as a chronic viral disease of the liver. Although drugs targeting the liver are in wide use and have shown efficacy, toxicity and other side effects have limited their usefulness. Inhibitors of hepatitis C virus (HCV) are useful to limit the establishment and progression of infection by HCV as well as in diagnostic assays for HCV.The compound (S)-isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate, designated herein as Compound I, also known as Sofosbuvir, is ...

Composition for Titanium Nitride Hard Mask and Etch Residue Removal

Aqueous compositions for stripping titanium nitride(TiN or TiNxOy) hard mask and removing etch residue are low pH aqueous composition comprising solvent, a weakly coordinating anion, amine, and at least two non-oxidizing trace metal ions. The aqueous compositions contain no non-ambient oxidizer, and are exposed to air. Bifluoride, or metal corrosion inhibitor may be added to the aqueous composition. Systems and processes use the aqueous compositions for stripping titanium nitride(TiN or TiNxOy) hard mask and removing titanium nitride(TiN or TiNxOy) etch residue. 1. An aqueous composition for selectively removing titanium nitride (TiN or TiNxOy) from a semiconductor device comprising Cu , W , low-k dielectric material and the titanium nitride , a weakly coordinating anion having negative charge highly dispersed throughout its structure;', 'an amine salt buffer;', 'at least two non-oxidizing trace metal ions and', 'the remaining is solvent selected from the group consisting of water, glycol, propylene glycol, lactic acid, acetic acid, sulfolanes, dimethyl sulfoxide, alkyl sulfone, and combinations thereof;', 'wherein the aqueous composition (1)contains no non-ambient oxidizer; (2) is exposed to air, and (3)has a pH less than 7., 'comprising2. The aqueous composition of claim 1 , wherein the weakly coordinating anion is in the range of 1.0-10.0 wt %; and is selected from the group consisting of p-toluenesulfonate (CHSO); sulfate (SO); nitrate(NO); triflate(CFSO);{'sub': f', '3', 'f', '4, 'sup': '−', 'perfluorosulfonates (RSO), in Ris a perfluoroalkylgroup from C, to C);'}{'sub': f', '2', '2', 'f', '1', '4', '6', '6', '4', '6, 'sup': −', '2−', '2−', '−', '−', '−, 'perfluorosulfonimides; ((R)NSO), wherein Ris a perfluoroalkylgroup from Cto C); hexafluorosilicate(SiF); hexafluorotitanate (TiF); tetrafluoroborate(BF); hexafluorophosphate (PF); hexafluoroantimonate (SbF6) ;'}{'sub': f', '4', 'f, 'sup': '−', 'perfluoroalkylaluminates((RO)Al), wherein Ris a perfluoroalkyl ...

FIRST PARTY ADVERTISEMENT SERVING

Adservers with the ability to access advertiser cookies and vice versa when both are serving from the advertiser's domain are provided, thereby avoiding the overhead and delay in backend cookie synchronization efforts. Further, advertising cookie data can be gathered regardless of whether a user is browsing a publisher's web site with an advertisement served by an adserver, or browsing the advertiser's web site, because the cookies were previously set when the user visited the advertiser's web site in the context of a first-party cookie. Even if the user has configured his or her browser to limit the setting of third-party cookies, the cookies can still be read by the adserver. By making cookie and advertising data immediately available in real time to both the advertiser and the adserver, the solution also provides for instantaneous and accurate targeting of web advertising to allow an educated ad selection process by either party. 1. A method of serving an advertisement to a client system , the method comprising:receiving an advertisement serving request at a server from a publisher web page directed to an adserver within a delegated sub-domain of an advertiser and redirected within a domain of the advertiser via a domain name service (DNS) server;receiving data from the client system set within the domain of the advertiser;selecting an advertisement from a plurality of candidate advertisements based at least upon the data set within the domain of the advertiser; andproviding updated data set within the domain of the advertiser via the delegated sub-domain of the advertiser.2. The method of further comprising serving the advertisement to the client system.3. The method of wherein the advertisement comprises an advertisement of the advertiser.4. The method of wherein the advertisement comprises an advertisement of a second advertiser different from the advertiser.5. The method of wherein the receiving operation further comprises redirecting the advertisement ...

ENHANCED ARTEMISININ-BASED COMBINATION THERAPY FOR TREATING PARASITIC MEDIATED DISEASE

The present invention describes a method of treating individuals suffering from microbial infections, including a parasitic disease such as malaria, by using an improved Artemisinin Combination Therapy (ACT), known as ActRx Tri-ACT Plus. The improved ACT therapy includes administering a combination of four drugs. In one embodiment of the present invention, the method includes administering to an individual a first composition comprising a therapeutically effective amount of an artemether spray sublingually. The individual is then administered a second composition, a therapeutically effective amount of artesunate. A third composition, an effective amount of berberine, or its pharmaceutically acceptable derivatives or salts is administered to the individual. A fourth composition, an effective amount of primaquine, or its pharmaceutically acceptable derivatives or salts is administered to the individual.

ARTEMISININ-BASED COMBINATION THERAPY FOR TREATING VIRAL MEDIATED DISEASE

The present invention describes a method of treating individuals suffering from microbial infections, including a viral infection such as Dengue Fever, using an improved Artemisinin Combination Therapy (ACT), known as Tri-ACT. The improved ACT therapy includes administering a combination of three drugs. In one embodiment of the present invention, the method includes administering to an individual a first composition comprising a therapeutically effective amount of an artemether spray sublingually. The individual is then administered a second composition, a therapeutically effective amount of artesunate. A third composition, an effective amount of berberine, or its pharmaceutically acceptable derivatives or salts is then administered to the individual.

Etchant Solutions and Method of Use Thereof

Etching compositions and method of using the etching compositions comprising potassium hydroxide; one or more than one additional alkaline compounds selected from the group consisting of TEAH, TMAF and NHOH; and water; or etching compositions comprising one or more than one inorganic alkali basic hydroxides selected from the group consisting of potassium hydroxide, cesium hydroxide, sodium hydroxide, rubidium hydroxide, or lithium hydroxide; optionally one or more than one additional alkaline compounds; water; and optionally one or more corrosion inhibitors; wherein the composition preferentially etches silicon present on a substrate as compared to silicon dioxide present on said substrate. 1. An etching composition comprising:potassium hydroxide;{'sub': '4', 'one or more than one additional alkaline compounds selected from the group consisting of TEAH, TMAF and NHOH; and'}water;wherein the composition preferentially etches silicon present on a substrate as compared to silicon dioxide present on said substrate.2. An etching composition comprising:one or more than one inorganic alkali basic hydroxides selected from the group consisting of potassium hydroxide, cesium hydroxide, sodium hydroxide, rubidium hydroxide, or lithium hydroxide;optionally one or more than one additional alkaline compounds;optionally one or more corrosion inhibitors; andwater;wherein the composition preferentially etches silicon present on a substrate as compared to silicon dioxide present on said substrate.3. The etchant composition of wherein the one or more inorganic alkali basic hydroxides are selected from the group consisting of potassium hydroxide and cesium hydroxide.4. The etchant composition of wherein the one or more inorganic alkali basic hydroxides comprise potassium hydroxide and cesium hydroxide.5. The etchant composition of wherein the one or more inorganic alkali basic hydroxides comprise potassium hydroxide and lithium hydroxide.6. The etchant composition of wherein the one or ...

Stripping Compositions Having High WN/W Etching Selectivity

A composition for cleaning integrated circuit substrates, the composition comprising: water; an oxidizer comprising an ammonium salt of an oxidizing species; a corrosion inhibitor comprising a primary alkylamine having the general formula: R′NH, wherein R′ is an alkyl group containing up to about 150 carbon atoms and will more often be an aliphatic alkyl group containing from about 4 to about 30 carbon atoms; optionally, a water-miscible organic solvent; optionally, an organic acid; optionally, a buffer speicies; optionally, a fluoride ion source; and optionally, a metal chelating agent. 1. A composition for cleaning integrated circuit substrates , the composition comprising:a. water;b. an oxidizer comprising an ammonium salt of an oxidizing species;{'sub': '2', 'c. a corrosion inhibitor comprising a primary alkylamine having the general formula: R′NH, wherein R′ is an alkyl group containing up to about 150 carbon atoms and will more often be an aliphatic alkyl group containing from about 4 to about 30 carbon atoms;'}d. optionally, a water-miscible organic solvent;e. optionally, an organic acid;f. optionally, a buffer speicies;g. optionally, a fluoride ion source; andh, optionally, a metal chelating agent.2. The composition of having a pH of from 3.0 to 6.5.3. The composition of wherein the ammonium salt of an oxidizing species is selected from the group consisting of ammonium chlorite (NHClO2) claim 1 , ammonium chlorate (NHClO) claim 1 , ammonium iodate (NHlO) claim 1 , ammonium perborate (NHBO) claim 1 , ammonium perchlorate (NHClO) claim 1 , ammonium periodate (NHlO) claim 1 , ammonium persulfate ((NH)SO) claim 1 , tetramethylammonium chlorite ((N(CH))ClO) claim 1 , tetramethylammonium chlorate ((N(CH))ClO) claim 1 , tetramethylammonium iodate ((N(CH)lO) claim 1 , tetramethylammonium perborate ((N(CH))BO) claim 1 , tetramethylammonium perchlorate ((N(CH))ClO) claim 1 , tetramethylammonium periodate ((N(CH))lO) claim 1 , tetramethylammonium persulfate ((N(CH))SO) ...

IMPROVED TNF BINDERS

The present invention relates to amino acid sequences, compounds and polypeptides binding to tumor necrosis factor alpha (“TNF” or “TNF-alpha”). In particular, the present invention relates to improved heavy-chain immunoglobulin single variable domains (also referred to herein as “ISV's” or “ISVDs”) binding to tumor necrosis factor alpha, as well as to proteins, polypeptides and other constructs, compounds, molecules or chemical entities that comprise such ISVDs, collectively TNF binders. Other aspects, embodiments, features, uses and advantages of the invention will be clear to the skilled person based on the disclosure herein. 1. An immunoglobulin single variable domain (ISVD) comprising SEQ ID NO: 40.2. An immunoglobulin single variable domain (ISVD) consisting of SEQ ID NO: 40. The present invention relates to amino acid sequences, compounds and polypeptides binding to tumor necrosis factor alpha (“TNF” or “TNF-alpha”). In particular, the present invention relates to improved heavy-chain immunoglobulin single variable domains (also referred to herein as “ISV's” or “ISVDs”) binding to tumor necrosis factor alpha, as well as to proteins, polypeptides and other constructs, compounds, molecules or chemical entities that comprise such ISVDs, collectively TNF binders. Other aspects, embodiments, features, uses and advantages of the invention will be clear to the skilled person based on the disclosure herein.In the present application, the amino acid residues/positions in an immunoglobulin heavy-chain variable domain will be indicated with the numbering according to Kabat. For the sake of convenience, gives a table listing some of the amino acid positions that will be specifically referred to herein and their numbering according to some alternative numbering systems (such as Aho and IMGT. Note: unless explicitly indicated otherwise, for the present description and claims, Kabat numbering is decisive; other numbering systems are given for reference only).With regard to ...

RECOMMENDATION MACHINE

A machine may be configured as a recommendation machine that makes one or more recommendations to one or more users. The machine may provide a recommendation based on one or more psychometric profiles that correspond to a user, a product, a manager for the product, or any suitable combination thereof. The user may be a potential buyer of the product, and the manager for the product may fully or partially manage the product and consequently affect the value of the product. The user's psychometric profile may describe market understanding and risk tolerance possessed by the user, and the manager's psychometric profile may describe market understanding and risk tolerance held by the manager. Such psychometric profiles may be used to make recommendations of products. In addition, a psychometric profile for the product itself may be used in the making of such recommendations. 1. A method comprising:by one or more processors of a machine, accessing first psychometric profile data stored in memory, the first psychometric profile data being associated with a user, the first psychometric profile data including a machine-generated market model of the user and a machine-generated risk model of the user, the machine-generated market model being generated from user input data indicative of extents to which the user agrees with a set of presented statements that characterize a market for products, the machine-generated risk model being generated from user input data indicative of a result of an implicit association test completed by the user;by one or more processors of the machine, accessing reference psychometric profile data that includes a plurality of reference psychometric profiles of products within the market, each reference psychometric profile among the plurality of reference psychometric profiles being correlated with a different product within the market;by one or more processors of the machine, identifying a corresponding product based on a comparison of the first ...

Inventory Management System

Apparatus and associated methods relate to an inventory management system having a machine learning engine trained to (a) dynamically predict a demand amount of the inventory in response to a set of near-future data and (b) generate a signal to order the amount of inventory as needed. In an illustrative example, the machine learning engine may be trained by a hotel's historical room booking data, the hotel's historical occupancy data, and corresponding inventory consumption data stored in a database. Various embodiments may enable, for example, the hotel to have better management on the status of inventories at various stages. For example, sufficient inventory may be available. In addition, providing the proper amount of inventory may also advantageously reduce the cost spent on unused products. 120-. (canceled)21. A computer program product (CPP) comprising: a program of instructions tangibly embodied on a computer readable medium wherein when the instructions are executed on a processor , the processor causes operations to be performed to predict an amount of inventory to be used by a hospitality provider , the operations comprising:(a) retrieving, by the processing engine, historical room booking data and corresponding subsequent historical linen inventory usage data of the hospitality provider from the data store;(b) iteratively training a neural network model by applying the historical room booking data to the neural network model as training input data and applying the corresponding subsequent historical linen inventory usage data to the neural network model as a training output data prediction goal of the neural network model, the training continuing until the neural network model generates an algorithm configured to predict linen inventory usage data, in response to test historical room booking data, within a predetermined accuracy range of test linen inventory usage data corresponding to the test historical room booking data;(c) retrieving, by the ...

Modified Chabazite Adsorbent Compositions, Methods of Making and Using them

An adsorbent having a composition comprising at least 90% chabazite where the chabazite is a single phase chabazite having an Si/Al ratio of 1.2 to 1.8, the chabazite includes a mixture of at least two types of cations, and each of the at least two types of cations are in a molar ratio relative to Al of at least 0.05. 1. An adsorbent comprising:a composition comprising at least 90% chabazite; whereinthe chabazite is a single phase chabazite having an Si/Al ratio of 1.2 to 1.8;the chabazite includes a mixture of at least two types of cations; andeach of the at least two types of cations are in a molar ratio relative to Al of at least 0.05.2. The adsorbent in accordance with claim 1 , wherein the at least two types of cations are selected from Li claim 1 , Na claim 1 , Ag claim 1 , K claim 1 , Ca claim 1 , Mg claim 1 , Zn claim 1 , Cu claim 1 , Ba claim 1 , and Sr ions.3. The adsorbent in accordance with claim 2 , wherein the mixture of the at least two types of cations comprise K and Na ions.4. The adsorbent in accordance with claim 3 , wherein the K and Na cations are in a molar ratio of 0.05 to 1.25 K:Na.5. The adsorbent in accordance with claim 3 , wherein the mixed cation chabazite is aK claim 3 ,NaCHA claim 3 , wherein a represents the number of potassium cations claim 3 , and a is from 1 to 7.6. The adsorbent in accordance with claim 3 , wherein the mixed cation chabazite is KNaCHA claim 3 , where b represents the total number of cations per unit of CHA and is from 12.9 to 16 claim 3 , and a represents the number of potassium cations and is from 1 to 7.7. The adsorbent composition of claim 3 , wherein the mixed cation chabazite is 1K claim 3 ,NaCHA; 2K claim 3 ,NaCHA; 3K claim 3 ,NaCHA; 4K claim 3 ,NaCHA; or 6K claim 3 ,NaCHA.8. The adsorbent in accordance with claim 1 , wherein the chabazite has a Si/Al ratio from 1.35 to 1.6.9. The adsorbent in accordance with claim 3 , wherein the chabazite is selected from 3K claim 3 ,NaCHA (1.6); 4K claim 3 ,NaCHA (1.6); ...

Modified Chabazite Adsorbent Compositions, Methods of Making and Using Them

A method for preparing an adsorbent is disclosed that includes mixing an NaY zeolite, aqueous Al(OH), and aqueous KOH, and then heating the resultant mixture for an allotted amount of time to achieve a composition comprising at least 90% single phase chabazite having an Si/Al ratio of 1.0 to 2.2. 1. A method for preparing an adsorbent , comprising:{'sub': '3', '(a) mixing NaY zeolite, aqueous Al(OH), and aqueous KOH; and'}(b) heating the resultant mixture of step (a) for an allotted amount of time to achieve a composition comprising at least 90% single phase chabazite having an Si/Al ratio of 1.0 to 2.2.2. The method of claim 1 , wherein the single phase chabazite comprises a potassium cation with a K:Al molar ratio of at least 0.90.3. The method of claim 1 , wherein the heating of step (b) is to about 70° C. to 120° C. and further comprises holding the temperature between 70° C. to 120° C. for 1-8 days.4. The method of claim 1 , wherein the heating of step (b) is to about 90° C.-100° C. and further comprises holding the temperature between 90° C. to 100° C. for 1-8 days.5. The method of claim 1 , further comprising conducting an ion exchange of the single phase chabazite to yield a single phase NaCHA composition having an Si/Al ratio of 1.0 to 2.2 claim 1 , wherein the Na/Al molar ratio is greater than 0.95.6. The method of claim 5 , wherein conducting the ion exchange comprises mixing the composition comprising at least 90% single phase chabazite having an Si/Al ratio of 1.0 to 2.2 with a 1M aqueous solution of NaCl having a 10-fold excess claim 5 , by mole % of NaCl relative to the moles of potassium cations in the single phase composition until the K is fully exchanged by Na to yield a single phase NaCHA composition.7. The method of claim 5 , wherein the single phase NaCHA composition is further ion exchanged to yield a single phase mixed cation CHA including at least two types of cations.8. The method of claim 7 , wherein each of the at least two types of ...

First party advertisement serving

Adservers with the ability to access advertiser cookies and vice versa when both are serving from the advertiser's domain are provided, thereby avoiding the overhead and delay in backend cookie synchronization efforts. Further, advertising cookie data can be gathered regardless of whether a user is browsing a publisher's web site with an advertisement served by an adserver, or browsing the advertiser's web site, because the cookies were previously set when the user visited the advertiser's web site in the context of a first-party cookie. Even if the user has configured his or her browser to limit the setting of third-party cookies, the cookies can still be read by the adserver. By making cookie and advertising data immediately available in real time to both the advertiser and the adserver, the solution also provides for instantaneous and accurate targeting of web advertising to allow an educated ad selection process by either party.

TiN Hard Mask and Etch Residue Removal

Composition, method and system for PVD TiN hard mask removal from 28/20 nm pattern wafers have been disclosed. The composition uses peroxide as oxidizing agent for PVD TiN hard mask removal under slightly basic conditions. The composition comprises bulky or long chain organic amines or polyalkylamine to improve removal/etching selectivity of PVD TiN vs CVD TiN. The composition further comprises long chain organic acids or amines to maintain Co compatibility. 2. The composition of claim 1 , wherein the peroxide is selected from the group consisting of hydrogen peroxide claim 1 , ammonium persulfate claim 1 , peracidic acid claim 1 , peroxybenzoic acid claim 1 , and combinations thereof.3. The composition of claim 1 , wherein the base is selected from the group consisting of tetraethylammonium hydroxide(TEAH) claim 1 , trimethylphenylammonium hydroxide claim 1 , tetramethylammonium hydroxide claim 1 , tetrabutylammonium hydroxide claim 1 , choline hydroxide claim 1 , ammonium hydroxide claim 1 , and combinations thereof.4. The composition of claim 1 , wherein the weak acid is carboxylic acid selected from the group consisting of citric acid claim 1 , oxalic acid claim 1 , malonic acid claim 1 , lactic acid claim 1 , adipic acid claim 1 , acetic acid claim 1 , iminodiacetic acid claim 1 , and combinations thereof.5. The composition of claim 1 , wherein the ammonium salt is selected from the group consisting of ammonium citrate claim 1 , ammonium acetate claim 1 , ammonium malonate claim 1 , ammonium adipate claim 1 , ammonium lactate claim 1 , ammonium iminodiacetate claim 1 , ammonium chloride claim 1 , ammonium bromide claim 1 , ammonium fluoride claim 1 , ammonium bifluoride claim 1 , ammonium sulfate claim 1 , and combinations thereof.6. The composition of claim 1 , wherein the corrosion inhibitor is selected from the group consisting of 1 claim 1 ,2 claim 1 ,4-triazole claim 1 , benzotriazole claim 1 , methyl-1H-benzotriazole claim 1 , 2-aminobenthothiazole claim ...

INVENTORY MANAGEMENT SYSTEM

Apparatus and associated methods relate to an inventory management system having a machine learning engine trained to (a) dynamically predict a demand amount of the inventory in response to a set of near-future data and (b) generate a signal to order the amount of inventory as needed. In an illustrative example, the machine learning engine may be trained by a hotel's historical room booking data, the hotel's historical occupancy data, and corresponding inventory consumption data stored in a database. Various embodiments may enable, for example, the hotel to have better management on the status of inventories at various stages. For example, sufficient inventory may be available. In addition, providing the proper amount of inventory may also advantageously reduce the cost spent on unused products. 1. An inventory management system , comprising:a processing engine; and, (a) retrieving, by the processing engine, a first set of data from the data store;', '(b) training on a neural network model in response to the retrieved first set of data; and,', '(c) retrieving, by the processing engine, a second set of data from the data store and applying the second set of data to the trained neural network model to generate a predicted amount of inventory to be used,', 'wherein the first set of data used to train the neural network model comprises historical booking data, and historical inventory usage data of the hospitality provider,', "wherein the second set of data comprises the hospitality provider's near future booking data."], 'a data store coupled to the processing engine and containing a program of instructions that, when executed by the processing engine, cause the processing engine to perform operations to predict an amount of inventory to be used by a hospitality provider, the operations comprising2. The inventory management system of claim 1 , wherein the first set of data used to train the neural network model further comprises the historical occupancy data of the ...

Alkali-Promoted Activated Alumina Adsorbent

An adsorbent for removing COfrom a gas mixture, the adsorbent comprising alumina and a carbonate compound where the carbonate to alumina IR absorbance intensity ratio is reduced by washing the adsorbent with water. The disclosure also describes a method of making adsorbent particles, process for removing COfrom a gas mixture using the adsorbent, and an adsorption unit using the adsorbent. 1. An adsorbent for use in a process to remove COfrom a gas mixture containing CO , the adsorbent comprising:alumina;a carbonate compound;one or more alkali metals wherein the adsorbent is 0.5 to 10 weight % of the one or more alkali metals;{'sup': 2', '2, 'wherein the surface area of the adsorbent ranges from 220 m/g to 400 m/g; and'}{'sub': carbonate', 'alumina', 'alumina', 'carbonate, 'sup': −1', '−1', '−1', '−1, 'wherein the adsorbent has a carbonate to alumina intensity ratio, R, the carbonate to alumina intensity ratio, R, having a value less than or equal to 0.0150, where the carbonate to alumina intensity ratio is as determined by Fourier Transform infrared (FTIR) spectroscopy of a crushed sample of the adsorbent, wherein the carbonate to alumina intensity ratio is a ratio of a peak absorbance intensity for carbonate, AI, to a peak absorbance intensity for alumina, AI, each peak absorbance intensity obtained after subtracting a baseline signal intensity,-where the peak absorbance intensity for alumina, AI, is observed at a wavenumber in a range from 420 cmto 520 cm, and the peak absorbance intensity for carbonate, AI, is observed at a wavenumber in a range from 1300 cmto 1400 cm.'}2. The adsorbent according to wherein the adsorbent is 90 to 99 weight % alumina.3. The adsorbent according to wherein the carbonate compound is an alkali carbonate.4. The adsorbent according to wherein the alkali carbonate is KCO.5. The adsorbent according to wherein the value of the carbonate to alumina intensity ratio ranges from 0.003 to 0.0150.6. A method for making adsorbent particles for ...

Alkali-Promoted Activated Alumina Adsorbent

An adsorbent for removing COfrom a gas mixture, the adsorbent comprising alumina and a carbonate compound where the carbonate to alumina IR absorbance intensity ratio is reduced by washing the adsorbent with water. The disclosure also describes a method of making adsorbent particles, process for removing COfrom a gas mixture using the adsorbent, and an adsorption unit using the adsorbent. 1. An adsorbent for use in a process to remove COfrom a gas mixture containing CO , the adsorbent comprising:alumina;a carbonate compound; andone or more alkali metals;wherein the total amount of alkali metals in the adsorbent is from 0.9 weight % to 10 weight %; and{'sub': carbonate', 'alumina', 'carbonate', 'alumina', 'alumina', 'carbonate, 'sup': −1', '−1', '−1', '−1, 'wherein the adsorbent has a carbonate to alumina intensity ratio, R, the carbonate to alumina intensity ratio, R, having a value less than or equal to 0.0150, where the carbonate to alumina intensity ratio is as determined by Fourier Transform infrared (FTIR) spectroscopy of a crushed sample of the adsorbent, wherein the carbonate to alumina intensity ratio is a ratio of a peak absorbance intensity for carbonate, AI, to a peak absorbance intensity for alumina, AI, (i.e. R=AI/AI), each peak absorbance intensity obtained after subtracting a baseline signal intensity, where the peak absorbance intensity for alumina, AI, is observed at an FTIR wavenumber in a range from 420 cmto 520 cm, and the peak absorbance intensity for carbonate, AI, is observed at an FTIR wavenumber in a range from 1300 cmto 1400 cm.'}2. The adsorbent according to wherein the total amount of alkali metals in the adsorbent is from 1.0 weight % to 8 weight %.3. The adsorbent according to wherein the surface area of the adsorbent ranges from 220 m/g to 400 m/g.4. The adsorbent according to wherein the amount of alumina in the adsorbent is from 90 to 99 weight %.5. The adsorbent according to wherein the alkali metals are Na and/or K.6. The adsorbent ...

TNF BINDERS

The present invention relates to amino acid sequences, compounds and polypeptides binding to tumor necrosis factor alpha (“TNF” or “TNF-alpha”). In particular, the present invention relates to improved heavy-chain immunoglobulin single variable domains (also referred to herein as “ISV's” or “ISVDs”) binding to tumor necrosis factor alpha, as well as to proteins, polypeptides and other constructs, compounds, molecules or chemical entities that comprise such ISVDs, collectively TNF binders. Other aspects, embodiments, features, uses and advantages of the invention will be clear to the skilled person based on the disclosure herein.

NON-INVASIVE IN-SITU IMAGING OF INTERIOR OF NUCLEAR REACTORS

Techniques, systems, and devices are disclosed for non-invasive monitoring and imaging of nuclear fuel inside a nuclear reactor using muon detector arrays. In one aspect, these detector arrays are placed outside the reactor vessel or building for investigating the reactors without access to the cores, therefore the imaging process is non-invasive. In some implementation, these detector arrays measure both muon scattering and absorption to enable imaging and characterizing not only the very high-Z fuel materials, but also other materials in the reactor, thereby obtaining a more complete picture of reactor status. When applied to damaged reactors, the disclosed proposed techniques, systems, and devices, through the process of providing an image, can reveal the presence (or absence) of damage to fuel rod assemblies or puddles of molten fuel at the bottom of the containment vessel, thus providing crucial information to guide decisions about remedial actions. 1. A method for non-invasive imaging of a reactor core inside a nuclear reactor , wherein the reactor core contains nuclear fuel , the method comprising:generating, by a first muon detector array at a first vertical surface of an enclosure of the nuclear reactor, hit signals representing cosmic-ray muons passing through the first muon detector array and entering into a volume defined by the enclosure, wherein the first muon detector array includes muon detectors arranged vertically along a first vertical plane substantially parallel to the first vertical surface of the enclosure;generating, by a second muon detector array at a second vertical surface of the enclosure opposite to the first vertical surface, hit signals representing cosmic-ray muons passing through the second muon detector array and entering into the volume defined by the enclosure, wherein the second muon detector array includes muon detectors arranged vertically along a second vertical plane substantially parallel to the second vertical surface of ...

Selectively Removing Titanium Nitride Hard Mask and Etch Residue Removal

Formulations for stripping titanium nitride hard mask and removing titanium nitride etch residue comprise an amine salt buffer, a non-ambient oxidizer, and the remaining being liquid carrier includes water and non-water liquid carrier selected from the group consisting of dimethyl sulfone, lactic acid, glycol, and a polar aprotic solvent including but not limited to sulfolanes, sulfoxides, nitriles, formamides and pyrrolidones. The formulations have a pH <4, preferably <3, more preferably <2.5. The aqueous formulations having water as liquid carrier and semi-aqueous formulation having water and non-polar aprotic solvent(s) further contain acidic fluoride. The formulations offer high titanium nitride etch rates while provide excellent compatibility towards W, AlN, AlO, and low k dielectric materials. The formulations may comprise weakly coordinating anions, corrosion inhibitors, and surfactants. Systems and processes use the formulations for stripping titanium nitride hard mask and removing titanium nitride etch residue. 1. A composition for selectively removing titanium nitride (TiN or TiNxOy; where x=0 to 1.3 and y=0 to 2) from a semiconductor device comprising titanium nitride and a second material; the composition comprising:an amine salt buffer;a non-ambient oxidizer; andliquid carrier;whereinthe composition comprises no hydrogen peroxide;the composition has a pH<4;the second material is selected from the group consisting of Cu, W, aluminum nitride (AlNx with x=0.5 to 1), aluminum oxide(AlOx with x=1 to 1.5), low-k dielectric material, and combinations thereof; andthe composition offers a removal selectivity of TiN or TiNxOy vs. the second material >1:1.2. The composition of claim 1 , wherein the amine salt buffer is present in the range of 0.5 to 10 wt % and is selected from the group consisting of:ammonium chloride; ammonium bisulfate; ammonium phosphates; ammonium oxalate; ammonium perfluorosulfonates; ammonium tetrafluoroborate; ammonium hexafluorotitanate; ...

METHODS AND COMPOSITIONS FOR THE PREPARATION OF AEROSOLS

The present invention relates to methods for the preparation of an aerosol. More specifically the present invention provides methods for the preparation of an aerosol of immunoglobulin single variable domains wherein the amount of aggregate formation is significantly reduced. The invention further provides aerosols prepared by the methods of the invention, as well as compositions for use in the methods of the invention. The invention further relates to methods for the preparations of such compositions, to containers, kits and aerosol delivery systems comprising such compositions and to uses of the same. 1. Method for reducing the percentage of aggregate formation in atomized material of immunoglobulin single variable domains comprising atomizing in a vibrating-mesh nebulizer a composition comprising an aqueous carrier and a polypeptide comprising one or more immunoglobulin single variable domains , wherein:the concentration of the polypeptide comprising one or more immunoglobulin single variable domains present in the composition is 50 mg/mL or more, wherein the aqueous carrier comprises saline (NaCl 0.9%), histidine, and phosphate buffered saline; andthe percentage of aggregate formation in the atomized material, as determined by SE-HPLC, is reduced compared to the percentage of aggregate formation in atomized material obtained from a composition of immunoglobulin single variable domains at a concentration of 5 mg/mL or atomized in a jet nebulizer.2. Method of claim 1 , wherein the composition further comprises a surfactant at a concentration between 0.001% and 1%.3. Method of claim 2 , wherein the surfactant is selected from polysorbates and poloxamers claim 2 , or wherein PEG is added as a surfactant-like compound.4. (canceled)5. (canceled)6. Method of claim 1 , wherein the polypeptide comprising one or more immunoglobulin single variable domains is present at a concentration of 50 mg/mL to 200 mg/mL and wherein the composition does not comprise a surfactant.738 ...

Cookie derivatives

Cookie derivatives and methods for generating cookie derivatives are provided. A cookie derivative comprises a transformation of at least one portion of data associated with a cookie (e.g., a name and/or data value). The cookie derivative may comprise a persistent or non-persistent cookie derivative that may be stored on a user's computing device (e.g., within a browser). The cookie derivative may alternatively comprise a virtual cookie derivative that is stored on a server (e.g., in a log file, a cache, or other data storage of the server).

COMPOSITIONS AND METHODS FOR TREATING HEPATITIS C VIRUS

Disclosed herein are a composition and unit dosage form for the treatment of hepatitis C virus (HCV) infection comprising GS-7977 and at least one pharmaceutically acceptable excipient, as well as methods for making said composition and unit dosage form. Also disclosed herein is a method of treating a subject, preferably a human, infected with hepatitis C virus, said method comprising administering to the subject for a time period an effective amount of GS-7977 and an effective amount of ribavirin. In one aspect, the method comprises administering to the subject an interferon-free treatment regimen comprising an effective amount of GS-7977 and an effective amount of ribavirin. In a particular aspect, the method is sufficient to produce an undetectable amount of HCV RNA in the subject for at least 12 weeks after the end of the time period. 1. A pharmaceutical composition comprising:a) about 25% to about 35% w/w of GS-7977; andb) at least one pharmaceutically acceptable excipient.2. The composition according to claim 1 , wherein the composition comprises about 30% to about 35% w/w of GS-7977.3. The composition according to claim 1 , wherein the composition comprises about 30% w/w of GS-7977.4. The composition according to claim 1 , wherein the composition comprises about 33% w/w of GS-7977.5. The composition according to claim 1 , wherein the composition comprises crystalline GS-7977.6. The composition according to claim 5 , wherein the crystalline GS-7977 has XRPD 2θ-reflections (°) at about:(1) 5.2, 7.5, 9.6, 16.7, 18.3, and 22.2;(2) 5.0, 7.3, 9.4, and 18.1;(3) 4.9, 6.9, 9.8, 19.8, 20.6, 24.7, and 26.1;(4) 6.9, 9.8, 19.7, 20.6, and 24.6;(5) 5.0, 6.8, 19.9, 20.6, 20.9, and 24.9;(6) 5.2, 6.6, 7.1, 15.7, 19.1, and 25.0; or(7) 6.1, 8.2, 10.4, 12.7, 17.2, 17.7, 18.0, 18.8, 19.4, 19.8, 20.1, 20.8, 21.8, and 23.3.7. The composition according to claim 6 , wherein the crystalline GS-7977 has XRPD 2θ-reflections (°) at about:(1) 5.0, 7.3, 9.4, and 18.1; or(2) 6.1, 8.2, 10.4, ...

COOKIE DERIVATIVES

Cookie derivatives and methods for generating cookie derivatives are provided. A cookie derivative comprises a transformation of at least one portion of data associated with a cookie (e.g., a name and/or data value). The cookie derivative may comprise a persistent or non-persistent cookie derivative that may be stored on a user's computing device (e.g., within a browser). The cookie derivative may alternatively comprise a virtual cookie derivative that is stored on a server (e.g., in a log file, a cache, or other data storage of the server). 1. A method for providing a virtual cookie derivative comprising:receiving a request for content at a first party server, the request for content including at least one cookie associated with a first party domain of an advertiser;transforming a value component of a name/value pair of cookie data associated with the at least one cookie in response to the request for content to generate a temporary virtual cookie derivative at the first party server, the temporary virtual cookie derivative residing on the first party server for a limited period of time and comprising a derivative data value derived from the data associated with the at least one cookie wherein the operation of transforming cookie data comprises removing privacy related information of the cookie data;passing the virtual cookie derivative to a third party ad server outside of the first party domain of the advertiser;evaluating, at the third party ad server, the derivative data value of the cookie derivative against targeting data to determine advertisement content to be returned in response to the request for content; andreturning the determined advertisement content from the third party ad server in response to the request for content,wherein the at least one cookie is not modified at a client browser.2. The method of wherein the cookie data is received at the first party server with a browser request.3. The method of wherein non-cookie data is used in generating ...

Bottle Feeding Device

A bottle feeding device, including a bottom piece of a bottle body having a first perimeter wall and a top piece of a bottle body having a second perimeter wall. The top piece is pivotally affixed to the bottom piece and is rotatable with respect to the bottom piece about an axis extending generally orthogonally through the first perimeter wall and the second perimeter wall. A pair of detent features is provided to restrain the bottom piece and the top piece into either a first relative rotational position or a second relative rotational position. A nipple is operatively affixed to the top piece of the bottle by a nipple ring threaded onto the top piece of the bottle. A method of feeding an infant and of manufacturing the bottle are also provided. 1. A bottle feeding device , comprising:a bottom piece of a bottle body having a first perimeter wall, the bottom piece having a bottom piece upper end that is opposite a bottom piece lower end, the bottom piece having a bottom piece central vertical axis;a top piece of the bottle body having a second perimeter wall, wherein the top piece has a top piece upper end and a top piece lower end opposite the top piece upper end, the top piece having a top piece central vertical axis, the top piece is pivotally affixed to the bottom piece such that the top piece lower end is proximal the bottom piece upper end, and the top piece is rotatable with respect to the bottom piece about an axis extending generally orthogonally through the first perimeter wall and the second perimeter wall;a liner forming a continuous storage volume, the liner positioned within the bottom piece and the top piece such that a liner opening is contiguous with the top piece upper end; anda nipple attachable to the top piece upper end, the nipple attachable to the top piece upper end;wherein the top piece is rotatable about the bottom piece in an upper portion of the bottle feeding device such that the top piece is radially outward of the bottom piece,wherein ...

CYSTEINE LINKED NANOBODY DIMERS

The present invention relates to dimers comprising a first polypeptide and a second polypeptide, wherein each of said first and second polypeptide comprises at least one immunoglobulin single variable domain (1ISVD) and a C-terminal extension comprising a cysteine moiety (preferably at the C-terminus), wherein said first polypeptide and said second polypeptide are covalently linked via a disulfide bond between the cysteine moiety of said first polypeptide and the cysteine moiety of said second polypeptide, in which the dimer outperformed the benchmark constructs, e.g. cognate multivalent and multispecific constructs, in various assays. The present invention provides methods for making the dimers of the invention. 1. Method for making dimers , comprising at least the steps of: at least one immunoglobulin single variable domain (ISVD) and', 'a C-terminal extension comprising a cysteine moiety, preferably at the C-terminus;, '(i) providing a first polypeptide, wherein said first polypeptide comprises'} at least one immunoglobulin single variable domain (ISVD) and', 'a C-terminal extension comprising a cysteine moiety, preferably at the C-terminus; and, '(ii) providing a second polypeptide, wherein said second polypeptide comprises'}(iii) oxidizing the thiol moiety of said cysteine moiety at the C-terminus of said first polypeptide and the thiol moiety of said cysteine moiety at the C-terminus of said second polypeptide by optionally adding oxidizing copper ions (Cu2+), and preferably at pH 6.5 to pH 7.5 to a disulfide derivative cystine;characterized in that the integrity of the ISVDs is maintained and said cystine is the only intermolecular disulfide bond present in the dimer; thereby making said dimers.2. The method according to claim 1 , wherein at least 80% claim 1 , such as 85% claim 1 , 90% claim 1 , 95% claim 1 , 99% or even more claim 1 , such as 100% of said first and said second polypeptide are dimerized claim 1 , for instance as determined by mass ...

Mobile Device Operating System for Providing Enhanced Communications Via Segmented Message Templates

Provided is a display control mechanism for improving functionality of a handheld mobile device including an operating system (OS). The display control mechanism includes a content delivery system (CDS) configured to create an advertising (ad) message, the add message being represented by templates formatted into a plurality of portions. A first template portion includes instructions directing how to render the ad message to interact with the mobile device based upon capabilities of the device, a second template portion includes instructions directing what to render as content of the ad message based upon the device capabilities, and a third template portion includes data for use in rendering the ad message. A content message layer manipulates the OS and the device capabilities, and includes one or more application programming interfaces (APIs) configured to receive, store, and render messages sent by CDS. 1. A display control mechanism for improving functionality of a handheld mobile device including an operating system (OS) , the display control mechanism comprising:a content delivery system (CDS) configured to create an advertising (ad) message, the ad message being represented by templates formatted into a plurality of portions;wherein (i) a first of the template portions includes instructions directing how to render the ad message to interact with the mobile device based upon capabilities of the device, (ii) a second of the template portions includes instructions directing what to render as content of the ad message based upon the device capabilities; and (iii) a third of the template portions includes data for use in rendering the ad message; andwherein the CDS is configured to compare the first template portion instructions to registered capabilities of other mobile devices to determine a percentage of the other mobile devices capable of receiving the ad message;a formatted data package for (i) transmitting the first, second, and third template portions ...

ADA COMPLIANT COIN RECYCLING DEVICE

The present invention relates generally to an ADA compliant coin recycler device that is capable of sorting a mixed denomination of coins, storing the coins and dispensing the desired amount of coins in the desired denomination. Additionally, the ADA compliant coin recycler device of the present invention also comprises a coin elevator assembly attached to the outside of the housing, which receives coins from the coin recycler and elevates the coins to an accessible height above the ADA's Standards for Accessible Design minimum reach requirement. 1. A coin recycling device with ADA-compliant features comprising:a housing;said housing including a coin input area for receiving coins;a coin sorter disposed in said housing for sorting the coins into different denominations;a plurality of coin hoppers for storing the coins of sorted denominations and operable to dispense coins stored therein; anda coin elevator assembly comprising a repositionable coin lift bucket that in a lower position is able to receive the coins dispensed from the coin hoppers and in an upper position is accessible at an at least ADA-compliant minimum reach height.2. (canceled)3. The coin recycling device of further comprising a cash till drawer housing for receiving a cash till drawer.4. The coin recycling device of wherein if the cash till drawer is inserted into the cash till drawer housing claim 3 , the coins from said coin hoppers are dispensed into appropriate compartments of the cash till drawer.5. The coin recycling device of wherein the coin elevator assembly is located on a side of said housing and the coins from said coin hoppers are dispensed onto a conveyor belt that moves the coins laterally into coin elevator assembly.6. A method for using a coin recycling device in an ADA-compliant manner claim 1 , said method comprising the steps of:identifying the user as one needing or desiring the coin recycling device to operate in an ADA-compliant manner;determining an amount of coins desired ...

Alkali-Promoted Activated Alumina Adsorbent

An adsorbent for removing COfrom a gas mixture, the adsorbent comprising alumina and a carbonate compound where the carbonate to alumina IR absorbance intensity ratio is reduced by washing the adsorbent with water. The disclosure also describes a method of making adsorbent particles, process for removing COfrom a gas mixture using the adsorbent, and an adsorption unit using the adsorbent. 1. A process for removing COfrom a gas mixture containing CO , the process comprising:{'sub': '2', 'claim-text': alumina;', 'a carbonate compound; and', 'one or more alkali metals;, 'passing the gas mixture containing COinto a bed containing an adsorbent, the adsorbent comprisingwherein the total amount of alkali metals in the adsorbent is from 0.9 weight % to 10 weight %; and{'sub': carbonate', 'alumina', 'carbonate', 'alumina', 'alumina', 'carbonate, 'sup': −1', '−1', '−1', '−1, 'wherein the adsorbent has a carbonate to alumina intensity ratio, R, the carbonate to alumina intensity ratio, R, having a value less than or equal to 0.0150, where the carbonate to alumina intensity ratio is as determined by Fourier Transform infrared (FTIR) spectroscopy of a crushed sample of the adsorbent, wherein the carbonate to alumina intensity ratio is a ratio of a peak absorbance intensity for carbonate, AI, to a peak absorbance intensity for alumina, AI, (i.e. R=AI/AI), each peak absorbance intensity obtained after subtracting a baseline signal intensity, where the peak absorbance intensity for alumina, AI, is observed at an FTIR wavenumber in a range from 420 cmto 520 cm, and the peak absorbance intensity for carbonate, AI, is observed at an FTIR wavenumber in a range from 1300 cmto 1400 cm; and'}{'sub': '2', 'withdrawing a CO-depleted gas from the bed.'}2. The process as claimed in wherein the total amount of alkali metals in the adsorbent is from 1.0 weight % to 8 weight %.3. The process as claimed in wherein the surface area of the adsorbent ranges from 220 m/g to 400 m/g.4. The process as ...

Titanium nitride hard mask and etch residue removal

Formulations for stripping titanium nitride (TiN or TiNxOy; x=0 to 1.3 and y=0 to 2) hard mask and removing titanium nitride etch residue are low pH (<4) comprise a weakly coordinating anion having negative charge highly dispersed throughout its structure, amine salt buffer, a non-oxidizing trace metal ion, a non-ambient trace oxidizer, and the remaining being solvent selected from the group consisting of water, sulfolane, dimethyl sulfide, lactic acid, glycol, and mixtures thereof. The formulations contain no hydrogen peroxide, and are exposed to air. Bifluoride, corrosion inhibitors, surfactants may be added to the formulations. Systems and processes use the formulations for stripping titanium nitride hard mask and removing titanium nitride etch residue.

Bombas de cuerpo hendido para suministradores de espuma y unidades de relleno.

En este documento se dan a conocer despachadores de espuma, unidades de relleno para despachadores de espuma y bombas para líquido para usarse en despachadores de espuma; además en este documento también se da a conocer una unidad de relleno para rellenar un sistema despachador de espuma; el despachador de espuma tiene un compresor de aire asegurado al mismo y el compresor de aire no se desecha con la unidad de relleno; la unidad de relleno incluye una bomba de líquido y un contenedor para conservar un líquido que hace espuma que está conectado a la bomba de líquido; la bomba de líquido incluye un alojamiento de bomba y una cámara de mezclado que tiene una válvula revisora de entrada y una válvula revisora de salida; la cámara de mezclado tiene una posición extendida con un primer volumen y una posición contraída con un segundo volumen; el alojamiento de bomba incluye una abertura a través de la misma configurada para recibir aire de un compresor de aire que no forma parte de la unidad de relleno; uno o más miembros de sellado de un solo sentido están ubicados dentro del alojamiento de bomba entre la abertura y la cámara de mezclado para evitar que el líquido pase a través de la abertura en el alojamiento de bomba para recibir aire; un elemento de espuma y una boquilla de salida se encuentran corriente abajo de la cámara de mezclado; la unidad de relleno está configurada para que la reciba un despachador de espuma que tiene un compresor de aire ubicado en el mismo y configurado para recibir aire presurizado del compresor de aire a través de la primera abertura; además, la unidad de relleno se puede desechar sin desechar el compresor de aire.

Process for the fluorination of boron hydrides

This invention relates to an improvement in a liquid phase process for the direct fluorination of borohydride salts including the B 10 H 10 −2 and B 12 H 12 −2 salts wherein said borohydride salt is contacted with fluorine, under conditions for forming said fluorinated borohydride salt. The improvement in the liquid phase process resides in effecting the fluorination of said borohydride salt in the presence of a reaction medium having an acidity between that of water and anhydrous HF. More specifically, the reaction medium should have a Hammett acidity, H o , between 0>H o >−11.

Proton conducting mediums for electrochemical devices and electrochemical devices comprising the same

An electrochemical device and a proton conducting medium for use in an electrochemical device having a proton conducting electrolyte comprising the formula: H a M b Q.nH 2 O where H is a proton, M is a cation, Q is the fluoroborate or fluoroheteroborate anion, n ranges from 0.01 to 1000, a ranges from 0.01 to 2 and b ranges from 0 to 2, a and b are chosen to render the formula electrically neutral, and when b is greater than 0, the ratio of b to a is less than 100 to 1.

Electrolytes, cells and methods of forming passivation layers

Electrolytes having a second cycle reduction current at 0.3 V vs Li/Li + that is less than that of the first cycle. The electrolyte comprising a salt, which will not electrochemically passivate. A cell comprising a positive electrode, a negative electrode and an electrolyte having a second cycle reduction current at 0.3 V vs Li/Li + that is less than that of the first cycle, said electrolyte comprising a salt, which will not electrochemically passivate. A method of forming an SEI layer in a cell comprising a positive electrode, a negative electrode and an electrolyte, said method comprising the step of overcharging the electrolyte prior to fabricating the cell, or said cell during the formation cycle.

Stable electrolyte counteranions for electrochemical devices

The invention relates to electrolyte salts for electrochemical devices of improved physical, chemical and electrochemical stability. The improvement resides in the use of anions of salts of the formula comprising: i) (B 12 F x Z 12-x ) 2− wherein Z comprises at least one of H, Cl, Br or OR; R comprises at least one of H, alkyl or fluoroalkyl, or at least one polymer and x is at least 3 on an average basis but not more than 12; ii) ((R′R″R′″)NB 12 F x Z (11-x) ) − , wherein N is bonded to B and each of R′, R″, R′″ comprise a member independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl and a polymer; Z comprises H, Cl, Br, or OR, where R comprises H, alkyl or perfluoroalkyl or a polymer, and x is an integer from 0 to 11; or iii) (R″″CB 11 F x Z (11-x) ) − , wherein R″″ is bonded to C and comprises a member selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, and a polymer, Z comprises H, Cl, Br, or OR, wherein R comprises H, alkyl or perfluoroalkyl or a polymer, and x is an integer from 0 to 11.

Process for the fluorination of boron hydrides

A process for fluorination of borohydride salts including providing a reaction medium comprising HF and a superacid. A borohydride salt compound is added to the reaction medium. The borohydride salt is reacted with the reaction medium under conditions to form a fluorinated borohydride salt. In addition, reactor vessels may be provided for reacting the HF, superacid additive and borohydride that are fabricated from materials resistant to superacid compositions.

Proton conducting mediums for electrochemical devices and electrochemical devices comprising the same

An electrochemical device and a proton conducting medium for use in an electrochemical device having a proton conducting electrolyte comprising the formula: €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ H a M b Q€¢nH 2 O where H is a proton, M is a cation, Q is the fluoroborate or fluoroheteroborate anion, n ranges from 0.01 to 1000, a ranges from 0.01 to 2 and b ranges from 0 to 2, a and b are chosen to render the formula electrically neutral, and when b is greater than 0, the ratio of b to a is less than 100 to 1.

Electrolytes, cells and methods of forming passivation layers

Electrolytes having a second cycle reduction current that is less than that of the first cycle. The electrolyte comprising a salt, which will not electrochemically passivate. A cell comprising a positive electrode, a negative electrode and an electrolyte having a second cycle reduction current that is less than that of the first cycle, said electrolyte comprising a salt, which will not electrochemically passivate. A method of forming an SEI layer in a cell comprising a positive electrode, a negative electrode and an electrolyte, said method comprising the step of overcharging the electrolyte prior to fabricating the cell, or said cell during the formation cycle.

Process for the fluorination of boron hydrides

A process for fluorination of borohydride salts including providing a reaction medium comprising HF and a superacid. A borohydride salt compound is added to the reaction medium. The borohydride salt is reacted with the with the reaction medium under conditions to form a fluorinated borohydride salt. In addition, reactor vessels may be provided for reacting the HF, superacid additive and borohydride that are fabricated from materials resistant to superacid compositions.

Proton conducting mediums for electrochemical devices and electrochemical devices comprising the same

An electrochemical device and a proton conducting medium for use in an electrochemical device having a proton conducting electrolyte comprising the formula: H a M b Q.nH 2 O where H is a proton, M is a cation, Q is the fluoroborate or fluoroheteroborate anion, n ranges from 0.01 to 1000, a ranges from 0.01 to 2 and b ranges from 0 to 2, a and b are chosen to render the formula electrically neutral, and when b is greater than 0, the ratio of b to a is less than 100 to 1.

Electrochemical devices comprising proton conducting mediums

An electrochemical device and a proton conducting medium for use in an electrochemical device having a proton conducting electrolyte comprising the formula: H a M b Q.nH 2 O where H is a proton, M is a cation, Q is the fluoroborate or fluoroheteroborate anion, n ranges from 0.01 to 1000, a ranges from 0.01 to 2 and b ranges from 0 to 2, a and b are chosen to render the formula electrically neutral, and when b is greater than 0, the ratio of b to a is less than 100 to 1.

Proton Conducting Mediums for Electrochemical Devices and Electrochemical Devices Comprising the Same

An electrochemical device and a proton conducting medium for use in an electrochemical device having a proton conducting electrolyte comprising the formula: H a M b Q.nH 2 O where H is a proton, M is a cation, Q is the fluoroborate or fluoroheteroborate anion, n ranges from 0.01 to 1000, a ranges from 0.01 to 2 and b ranges from 0 to 2, a and b are chosen to render the formula electrically neutral, and when b is greater than 0, the ratio of b to a is less than 100 to 1.

Electrolytes, electrolyte additives and cells

An electrolyte comprising a salt, which will not electrochemically passivate and at least two additives. A cell comprising a positive electrode, a negative electrode and an electrolyte comprising a salt, which will not electrochemically passivate and at least two additives.

Process for the Fluorination of Boron Hydrides

A process for fluorination of borohydride salts including providing a reaction medium comprising HF and a superacid. A borohydride salt compound is added to the reaction medium. The borohydride salt is reacted with the with the reaction medium under conditions to form a fluorinated borohydride salt. In addition, reactor vessels may be provided for reacting the HF, superacid additive and borohydride that are fabricated from materials resistant to superacid compositions.

Cysteine linked nanobody dimers

The present invention relates to dimers comprising a first polypeptide and a second polypeptide, wherein each of said first and second polypeptide comprises at least one immunoglobulin single variable domain (1ISVD) and a C-terminal extension comprising a cysteine moiety (preferably at the C-terminus), wherein said first polypeptide and said second polypeptide are covalently linked via a disulfide bond between the cysteine moiety of said first polypeptide and the cysteine moiety of said second polypeptide, in which the dimer outperformed the benchmark constructs, e.g. cognate multivalent and multispecific constructs, in various assays. The present invention provides methods for making the dimers of the invention.

Compositions and methods for treating hepatitis C virus

Disclosed herein are a composition and unit dosage form for the treatment of hepatitis C virus (HCV) infection comprising GS-7977 and at least one pharmaceutically acceptable excipient, as well as methods for making said composition and unit dosage form. Also disclosed herein is a method of treating a subject, preferably a human, infected with hepatitis C virus, said method comprising administering to the subject for a time period an effective amount of GS-7977 and an effective amount of ribavirin. In one aspect, the method comprises administering to the subject an interferon-free treatment regimen comprising an effective amount of GS-7977 and an effective amount of ribavirin. In a particular aspect, the method is sufficient to produce an undetectable amount of HCV RNA in the subject for at least 12 weeks after the end of the time period.

COMPUTER SOFTWARE VERIFICATION PROCEDURE.

EL CODIGO FUENTE DE UN PROGRAMA DE ORDENADOR QUE TIENE UN FORMATO CONOCIDO ESTA DIVIDIDO EN UNIDADES Y VERIFICADO, UNIDAD POR UNIDAD, POR INSTRUMENTACION AUTOMATICA DEL CODIGO Y GENERACION DE UN PROGRAMA COMPROBADOR DE EJECUCION QUE EJECUTA TODAS LAS SUBDIVISIONES DE UNA UNIDAD DE CODIGO INSTRUMENTADA. SE USAN PROCESADORES PARA GENERAR EL PROGRAMA COMPROBADOR DE EJECUCION Y PARA NORMALIZAR EL FORMATO DEL CODIGO E INSERTAR SENTENCIAS DE SEGUIMIENTO EJECUTABLES DENTRO DE CADA BLOQUE DE CODIGO REFORMADO ENTRE LAS SENTENCIAS DE CONTROL. UN PSEUDOCODIGO QUE TIENE SOLAMENTE SENTENCIAS CONTROL Y TABLAS QUE IDENTIFICAN LAS UNIONES VALIDAS ENTRE BLOQUES DE CODIGO ES GENERADO POR OTRO PROCESADOR PARA SER USADO POR UN VERIFICADOR SELECCIONANDO VALORES DE VARIABLES DE ENTRADA Y SALIDA PREVISTOS PARA CASOS DE COMPROBACION QUE EJECUTAN CADA BLOQUE DEL CODIGO EN UNA UNIDAD SELECCIONADA. LOS RESULTADOS DE LA COMPROBACION SE IMPRIMEN INDICANDO LA SECUENCIA DE UNION DE BLOQUES GENERADA POR CADA CASO DE COMPROBACION, LOS VALORES PREVISTOS DE SALIDA Y LOS VALORES ACTUALES DE SALIDA. THE SOURCE CODE OF A COMPUTER PROGRAM THAT HAS A KNOWN FORMAT IS DIVIDED IN UNITS AND VERIFIED, UNIT BY UNIT, BY AUTOMATIC INSTRUMENTATION OF THE CODE AND GENERATION OF A VERIFICATION PROGRAM OF EXECUTION BY ONE UNIT OF A COIG UNIT. PROCESSORS ARE USED TO GENERATE THE EXECUTION CHECK PROGRAM AND TO STANDARDIZE THE CODE FORMAT AND INSERT EXECUTABLE TRACKING JUDGMENTS WITHIN EACH BLOCK OF REFORMED CODE BETWEEN THE CONTROL JUDGMENTS. A PSEUDOCODE THAT HAS ONLY CONTROL SENTENCES AND TABLES THAT IDENTIFY VALID JOINTS BETWEEN CODE BLOCKS IS GENERATED BY ANOTHER PROCESSOR TO BE USED BY A VERIFICATOR BY SELECTING ENTRY AND OUTPUT VARIABLES INTENDED FOR A CHECKED CASE THAT SHOULD BE SELECTED UNIT. THE RESULTS OF THE CHECK ARE PRINTED INDICATING THE BLOCK JOINT SEQUENCE GENERATED BY EACH CHECK CASE, THE EXPECTED DEPARTURE VALUES AND THE CURRENT DEPARTURE VALUES.

Novel antigen binding dimer-complexes, methods of making and uses thereof

In a broad aspect the present invention generally relates to novel dimer-complexes (herein called "non-fused-dimers" or NFDs) comprising single variable domains, methods of making these complexes and uses thereof. These non-covalently bound dimer-complexes consist of two identical monomers that each comprises of one or more single variable domains (homodimers) or of two different monomers that each comprises on or more single variable domains (heterodimers). The subject NFDs have typically altered e.g. improved binding characteristics over their monomeric counterpart. The NFDs of the invention may further be engineered through linkage by a flexible peptide or cysteines in order to improve the stability. This invention also describes conditions under which such NFDs are formed and conditions under which the formation of such dimers can be avoided.

Methods and compositions for the preparation of aerosols

The present invention relates to methods for the preparation of an aerosol. More specifically the present invention provides methods for the preparation of an aerosol of immunoglobulin single variable domains wherein the amount of aggregate formation is significantly reduced. The invention further provides aerosols prepared by the methods of the invention, as well as compositions for use in the methods of the invention. The invention further relates to methods for the preparations of such compositions, to containers, kits and aerosol delivery systems comprising such compositions and to uses of the same.

Cysteine linked nanobody dimers

The present invention relates to dimers comprising a first polypeptide and a second polypeptide, wherein each of said first and second polypeptide comprises at least one immunoglobulin single variable domain (1ISVD) and a C-terminal extension comprising a cysteine moiety (preferably at the C-terminus), wherein said first polypeptide and said second polypeptide are covalently linked via a disulfide bond between the cysteine moiety of said first polypeptide and the cysteine moiety of said second polypeptide, in which the dimer outperformed the benchmark constructs, e.g. cognate multivalent and multispecific constructs, in various assays. The present invention provides methods for making the dimers of the invention.

Improved tnf binders

The present invention relates to amino acid sequences, compounds and polypeptides binding to tumor necrosis factor alpha (" TNF " or " TNF-alpha "). In particular, the present invention relates to improved heavy-chain immunoglobulin single variable domains (also referred to herein as " ISV's " or " ISVDs ") binding to tumor necrosis factor alpha, as well as to proteins, polypeptides and other constructs, compounds, molecules or chemical entities that comprise such ISVDs, collectively TNF binders. Other aspects, embodiments, features, uses and advantages of the invention will be clear to the skilled person based on the disclosure herein.

Chromatography-free antibody purification method

The present invention relates method for purifying antibodies, said method comprising a limited number of steps white still allowing obtaining high yields of purified antibodies with an appropriate degree of purity. Briefly, this method comprises only filtration and precipitation steps, omitting the need for chromatography steps.

Novel antigen-binding dimer complexes, process for their preparation and their use

Ein stabiles NFD, erhältlich durch ein Verfahren, umfassend den Schritt der Konzentration eines Polypeptids, umfassend mindestens eine einzelne variable Domäne. A stable NFD obtainable by a method comprising the step of concentrating a polypeptide comprising at least a single variable domain.

Novel antigen binding dimer complexes, methods of making and uses thereof

In a broad aspect the present invention generally relates to novel dimer-complexes (herein called "non-fused-dimers" or NFDs) comprising single variable domains, methods of making these complexes and uses thereof. These non-covalently bound dimer-complexes consist of two identical monomers that each comprises of one or more single variable domains (hornodimers) or of two different monomers that each comprises on or more single variable domains (heterodimers). The subject NFDs have typically altered e.g. improved binding characteristics over their monomeric counterpart. The NFDs of the invention may further be engineered through linkage by a flexible peptide or cysteines in order to improve the stability. This invention also describes conditions under which such NFDs are formed and conditions under which the formation of such dimers can be avoided.

Novel antigen binding dimer-complexes, methods of making and uses thereof

In a broad aspect the present invention generally relates to novel dimer-complexes (herein called "non-fused-dimers" or NFDs) comprising single variable domains, methods of making these complexes and uses thereof. These non-covalently bound dimer-complexes consist of two identical monomers that each comprises of one or more single variable domains (homodimers) or of two different monomers that each comprises on or more single variable domains (heterodimers). The subject NFDs have typically altered e.g. improved binding characteristics over their monomeric counterpart. The NFDs of the invention may further be engineered through linkage by a flexible peptide or cysteines in order to improve the stability. This invention also describes conditions under which such NFDs are formed and conditions under which the formation of such dimers can be avoided.

Methods and compositions for the preparation of aerosols

The present invention relates to methods for the preparation of an aerosol. More specifically the present invention provides methods for the preparation of an aerosol of immunoglobulin single variable domains wherein the amount of aggregate formation is significantly reduced. The invention further provides aerosols prepared by the methods of the invention, as well as compositions for use in the methods of the invention. The invention further relates to methods for the preparations of such compositions, to containers, kits and aerosol delivery systems comprising such compositions and to uses of the same.

Improved tnf binders

The present invention relates to amino acid sequences, compounds and polypeptides binding to tumor necrosis factor alpha ( "TNF" or "TNF-alpha" ). In particular, the present invention relates to improved heavy-chain immunoglobulin single variable domains (also referred to herein as "ISV's" or "ISVDs" ) binding to tumor necrosis factor alpha, as well as to proteins, polypeptides and other constructs, compounds, molecules or chemical entities that comprise such ISVDs, collectively TNF binders. Other aspects, embodiments, features, uses and advantages of the invention will be clear to the skilled person based on the disclosure herein.

TNF binders

The present invention relates to amino acid sequences, compounds and polypeptides binding to tumor necrosis factor alpha (“TNF” or “TNF-alpha”). In particular, the present invention relates to improved heavy-chain immunoglobulin single variable domains (also referred to herein as “ISV's” or “ISVDs”) binding to tumor necrosis factor alpha, as well as to proteins, polypeptides and other constructs, compounds, molecules or chemical entities that comprise such ISVDs, collectively TNF binders. Other aspects, embodiments, features, uses and advantages of the invention will be clear to the skilled person based on the disclosure herein.

TNF binders

The present invention relates to amino acid sequences, compounds and polypeptides binding to tumor necrosis factor alpha (“TNF” or “TNF-alpha”). In particular, the present invention relates to improved heavy-chain immunoglobulin single variable domains (also referred to herein as “ISV's” or “ISVDs”) binding to tumor necrosis factor alpha, as well as to proteins, polypeptides and other constructs, compounds, molecules or chemical entities that comprise such ISVDs, collectively TNF binders. Other aspects, embodiments, features, uses and advantages of the invention will be clear to the skilled person based on the disclosure herein.

Improved tnf binders

The present invention relates to amino acid sequences, compounds and polypeptides binding to tumor necrosis factor alpha ( "TNF" or "TNF-alpha" ). In particular, the present invention relates to improved heavy-chain immunoglobulin single variable domains (also referred to herein as "ISV's" or "ISVDs" ) binding to tumor necrosis factor alpha, as well as to proteins, polypeptides and other constructs, compounds, molecules or chemical entities that comprise such ISVDs, collectively TNF binders. Other aspects, embodiments, features, uses and advantages of the invention will be clear to the skilled person based on the disclosure herein.

Chromatography-free antibody purification method

The present invention relates method for purifying antibodies, said method comprising a limited number of steps while still allowing obtaining high yields of purified antibodies with an appropriate degree of purity. Briefly, this method comprises only filtration and precipitation steps, omitting the need for chromatography steps.

Systems and Methods for Controlling Electronic Circuitry with Separated Controllers

Dodecaborate salt radical anion compositions and methods for making and using such compositions

The disclosure relates to new compositions comprising an, B12FH12-x anion that may be prepared chemically or electrochemically by oxidation of B12FH12-x2- salts. This anion can be generated electrochemically in a voltammetry experiment, or by chemically by treatment of the (2-) anions with powerful oxidants such as XeF2 or N02(+) salts. The new compositions can be used as 1 electron chemical oxidants and in electrochemical cells such as lithium ion batteries where their fomation at elevated potential can serve to limit the upper limit of voltage during the overcharge of such a cell.

Compositions and methods for treating hepatitis c virus

Disclosed herein are a composition and unit dosage form for the treatment of hepatitis C virus (HCV) infection comprising GS-7977 and at least one pharmaceutically acceptable excipient, as well as methods for making said composition and unit dosage form. Also disclosed herein is a method of treating a subject, preferably a human, infected with hepatitis C virus, said method comprising administering to the subject for a time period an effective amount of GS-7977 and an effective amount of ribavirin. In one aspect, the method comprises administering to the subject an interferon-free treatment regimen comprising an effective amount of GS-7977 and an effective amount of ribavirin. In a particular aspect, the method is sufficient to produce an undetectable amount of HCV RNA in the subject for at least 12 weeks after the end of the time period.

Storage structure with mezzanine access and method of assembly

A modularly constructed storage structure with mezzanine access. The storage structure is provided in the form of a row of storage cabinets stacked on top of each other thereby providing base cabinets and upper storage cabinets. The storage cabinets have internal supporting structural framework which include vertical front and back beams and horizontal side beams with the frameworks of the stacked cabinets interconnected, and the vertical back beams of the base cabinets are also secured to an underlying supporting floor. The mezzanine structure, which is attached to the cabinet structure, includes a plurality of spaced horizontally aligned cantilever beams of predetermined length which penetrate the storage structure and are respectively connected directly or indirectly to front and back vertical beams of the cabinet structure. Overhang ends of these cantilever beams extend beyond the front face of the cabinet structure for cantilevered support thereon of a mezzanine deck. Decking is supported on these beams overhangs for mezzanine access to the upper storage cabinets. Since the mezzanine structure is entirely supported in cantilever fashion, no underlying vertical supports are required. A stairway may be attached as desired.

Method for the delivery of a biologically active agent

A method of manufacturing a stable nanosuspension for delivery of a biologically active agent into the bloodstream of a subject is disclosed. A microfluidizable mixture is initially formed and processed via a microfluidization process to form the stable nanosuspension, which may be administered via the buccal mucosa or other suitable routes of administration. This product demonstrates increased bioavailability, enhanced period of onset, and enhanced stability for a controlled-release product.

Novel antigen binding dimer-complexes, methods of making and uses thereof

In a broad aspect the present invention generally relates to novel dimer-complexes (herein called "non-fused-dimers" or NFDs) comprising single variable domains, methods of making these complexes and uses thereof. These non-covalently bound dimer-complexes consist of two identical monomers that each comprises of one or more single variable domains (homodimers) or of two different monomers that each comprises on or more single variable domains (heterodimers). The subject NFDs have typically altered e.g. improved binding characteristics over their monomeric counterpart. The NFDs of the invention may further be engineered through linkage by a flexible peptide or cysteines in order to improve the stability. This invention also describes conditions under which such NFDs are formed and conditions under which the formation of such dimers can be avoided.

Preparation of 1,4-bis-(difluoromethyl)benzene

Sulfur tetrafluoride is used at subambient temperatures and near ambient pressures to deoxofluorinate 1,4-terephthalaldehyde in a solvent of hydrogen fluoride end produce 1,4-bis-(difluoromethyl) benzene in very high yield and purity. This product a precursor of octafluoro-[2,2]paracyclophane, known as "AF4", that can be polymerized into useful films having excellent dielectric properties. The HF can be diluted with neutral organic solvents.

IMPROVED RHO ADSORBENT COMPOSITIONS, METHODS FOR MANUFACTURING AND USING THEM

En la presente se divulgan zeolitas RHO innovadoras útiles como adsorbentes selectivos cinéticamente para oxígeno y/o nitrógeno. Los adsorbentes se pueden utilizar en procesos de adsorción por oscilación de presión para adsorber selectivamente oxígeno y/o nitrógeno de corrientes de alimentación, tales como una corriente de aire o una corriente de argón crudo. También se divulgan métodos innovadores para preparar zeolitas RHO, incluidas, en particular, zeolitas RHO con cationes mezclados. Innovative RHO zeolites useful as kinetically selective adsorbents for oxygen and / or nitrogen are disclosed herein. Adsorbents can be used in pressure swing adsorption processes to selectively adsorb oxygen and / or nitrogen from feed streams, such as a stream of air or a stream of raw argon. Innovative methods for preparing RHO zeolites are also disclosed, including, in particular, RHO zeolites with mixed cations.

Operating method of an iron making installation and associated operating installation.

La invención se relaciona con un método para operar una instalación de fabricación de hierro, en la cual el material de desecho se seca usando un gas de secado, el gas de secado que comprende un gas de escape de una planta de sinterización, y el material seco se tuesta en un gas de tostación, para producir carbón y un gas de escape de la tostación. La invención también está relacionada con la instalación asociada.

TRANS-5-CHLORINE-2-METHYL-2,3,3A, 12B-TETRAHIDRO-1H-DIBENZ- [2,3: 6,7] OXEPINO [4,5-C] PIRROL 50% AMORFO BASED ON TOTAL WEIGHT OF THE COMPOUND; PREPARATION PROCEDURE; PHARMACEUTICAL COMPOSITION; AND USE FOR THE TREATMENT OF A SELECTED DISORDER BETWEEN E

Crystalline forms of antiviral sofosbuvir analogues

Crystalline solid forms of the anti-HCV compound (S)-isopropyl 2-((S)-(((2R,3R,4R,5R)- 5-(2,4-dioxo-3,4-dihydropyrimidin-l(2H)-yl)-4-fluoro-3-hydroxy-4- methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate (Compound I) are described. Also provided are processes of making and methods of using the crystalline forms.

Process for the synthesis of aryl sulfurpentafluorides

A process is described for the synthesis of an aryl sulfur pentafluoride compound. In one embodiment of the present invention, there is provided a process for preparing an aryl sulfurpentafluoride compound comprising: combining an at least one aryl sulfur compound with a fluorinating agent to at least partially react and form an intermediate aryl sulfurtrifluoride product; and exposing the intermediate aryl sulfurtrifluoride product to the fluorinating agent and optionally a fluoride source to at least partially react and form the aryl sulfurpentafluoride compound.

Dodecaborate salt radical anion compositions and methods for making and using such compositions.

La descripción se relaciona a nuevas composiciones que comprenden un anión B12FxH12-x- que se pueden preparar químicamente o electroquímicamente por la oxidación de las sales B12FxH12-x2-. Este anión se puede generar electroquímicamente en un experimento de voltametría, o mediante químicamente por el tratamiento de los aniones (2-) con oxidantes potentes tales como las sales XeF2 o NO2(+). Las nuevas composiciones se pueden utilizar como oxidantes químicos de 1 electrón y en celdas electroquímicas tales como baterías de ión de litio donde su formación en potencial elevado puede servir para limitar el límite superior de voltaje durante la sobrecarga de tal celda.

High purity lithium polyhalogenated boron cluster salts useful in lithium batteries

The present invention relates to lithium secondary batteries comprising a negative electrode, a positive electrode, a separator and a lithium-based electrolyte carried in an aprotic solvent, and to the electrolyte compositions. The electrolyte comprises a lithium salt of the formula: Li 2 B 12 F x H 12-x-y Z y where x+y is from 3 to 12, and x and y are independently from 0 to 12, and Z comprises at least one of Cl and Br.