Oil field process control system

An oil field process control system including a field versatile control gateway component that interfaces with a plurality of field devices using a broad range of hardwired and wireless protocols, offering in-the-field monitoring and control of each of the field devices and communicates with a remote central control room, exchanging data between the control room and the field using a multiplexed protocol that offers high data speeds and bandwidth, enabling a significant reduction of the amount of wiring, and conduits and other infrastructure expenses that would otherwise be incurred for such a highly reliable communications system.

Wearable vibrotactile speech aid

A method for training vibrotactile speech perception in the absence of auditory speech can comprise selecting a first word, generating a first control signal configured to cause at least one vibrotactile transducer to vibrate against a person's body with a first vibration pattern based on the first word, sampling a second word spoken by the person, generating a second control signal configured to cause at least one vibrotactile transducer to vibrate against the person's body with a second vibration pattern based on the sampled second word, and presenting a comparison between the first word and the second word to the person. An array of vibrotactile transducers can be in contact with the person's body. A method for improving auditory and/or visual speech perception in adverse listening conditions or for hearing-impaired individuals can also comprise sampling a speech signal, extracting a speech envelope, and generating a control signal configured to cause a vibrotactile transducer to vibrate again a person's body with an intensity that varies over time based on the speech envelope.

Integrated monitoring, control and equipment maintenance and tracking system

An integrated monitoring, control and equipment maintenance and tracking system and method is provided for managing a plurality of field devices. The integrated and coordinated system includes the monitoring and control system that uses safety subsystem field device data and process control subsystem field device data. When a compromised field device is determined, e.g., by the safety system and/or the process control system, information about testing, maintenance, repair or replacement is conveyed to the monitoring and control system. This information is used to modify the work orders created by the equipment maintenance and tracking system processor such that the compromised field device, or a field device at a location of the compromised field device, is not subject to unnecessary or excessively redundant testing.

Tongue with pre-folding section

An example embodiment includes a tongue includes a forming surface of a forming channel, the forming channel configured to enable the shaping of shredded material into a desired form as a shredded material is drawn through the forming channel and an arrangement to introduce at least a portion of a web component adjacent a portion of the forming surface such that the introduced web component portion may be operative upon the drawn shredded material as a source of additional drawing action. The tongue may include an arrangement to draw a moving web into the tongue through a channel that converges with the working surface of the tongue, whereby the moving web is interposable between a moving column of shredded material and the first surface portion of the working surface to reduce friction. The tongue may further comprise an arrangement comprising a scalloped surface portion along the working surface of the tongue.

Method and apparatus for controlling liquid crystal states

A method is disclosed of electrically controlling state transition of a liquid crystal material in a device (200). The device (200) comprises the liquid crystal material (213) and a polymeric structure (210) consisting of polymerised liquid crystal material with a selected liquid crystal state. The method comprises: applying an electric field to the liquid crystal material (213) to force the liquid crystal material (213) into a high-energy state; reducing the strength of the electric field to cause a lower-energy state region of the liquid crystal material (213) to nucleate on at least a part of the polymeric structure (210).

Trending topic driven cache eviction management

A content serving data processing system is configured for trending topic cache eviction management. The system includes a computing system communicatively coupled to different sources of content objects over a computer communications network. The system also includes a cache storing different cached content objects retrieved from the different content sources. The system yet further includes a cache eviction module. The module includes program code enabled to manage cache eviction of the content objects in the cache by marking selected ones of the content objects as invalid in accordance with a specified cache eviction strategy, detect a trending topic amongst the retrieved content objects, and override the marking of one of the selected ones of the content objects as invalid and keeping the one of the selected ones of the content objects in the cache when the one of the selected ones of the content objects relates to the trending topic.

Mitigation of catalyst inhibition in olefin polymerization

This disclosure relates to a process for polymerization comprising providing a recycle stream, wherein the recycle stream comprises one or more C 6 to C 12 conjugated or non- conjugated diene monomers and one or more C 1 to C 40 oxygenates. The recycle stream is contacted with an adsorbent bed to produce a treated recycle stream; wherein the adsorbent bed comprises at least two adsorbents to remove quenching agent and C 1 to C 40 oxygenates.

Controlled deployable medical device and method of making the same

Controlled deployable medical devices that are retained inside a body passage and in one particular application to vascular devices used in repairing arterial dilations, e.g., aneurysms. Such devices can be adjusted during deployment, thereby allowing at least one of a longitudinal or radial re-positioning, resulting in precise alignment of the device to an implant target site.

Adhesive compositions and methods for their manufacture

Un método para preparar partículas resistentes a la aglomeración que comprende las etapas de: a. proporcionar partículas de composición pegajosa con un límite elástico sin confinar de al menos 718 Pa (15 lbs/ft2) a o por encima de 25ºC medido por ASTM D6773; b. aumentar la pegajosidad de las partículas de composición pegajosa poniendo en contacto la partícula de composición pegajosa con un primer fluido a una temperatura de al menos 25ºC; y c. poner en contacto las partículas de composición pegajosa con una composición antibloqueante mientras las partículas de composición pegajosa están en contacto con el primer fluido en donde el primer fluido está a una temperatura de al menos 25ºC, en donde las partículas de composición pegajosa son pelets de poliolefina y están recubiertas al menos parcialmente con la composición antibloqueante. A method for preparing agglomeration resistant particles comprising the steps of: a. providing particles of sticky composition with an unconfined elastic limit of at least 718 Pa (15 lbs / ft2) at or above 25 ° C as measured by ASTM D6773; b. increasing the stickiness of the particles of sticky composition by contacting the particle of sticky composition with a first fluid at a temperature of at least 25 ° C; and c. contacting the particles of sticky composition with an anti-blocking composition while the particles of sticky composition are in contact with the first fluid where the first fluid is at a temperature of at least 25 ° C, where the particles of sticky composition are polyolefin pellets and are at least partially coated with the anti-blocking composition.

Adhesive Compositions And Methods Of Making The Same

Provided are methods for preparing agglomeration resistant particles composed of tacky polymer compositions. The method includes the steps of providing particles of the polymer composition at or above the glass transition temperature of the polymer composition, increasing the tackiness of the polymer composition particles by contacting the polymer composition particle with a first fluid at an elevated temperature, while the polymer composition particles are in contact with the first fluid, contacting the polymer composition particles with an antiblock composition, and separating the polymer composition particles from the first fluid. These methods at least partially coat the polymer composition particles with the antiblock composition.

Process for oligomer production and saturation

A process for the production of C 8 and higher olefins by the oligomerization of light olefins to heavier olefins is improved by the addition of cycloparaffins to the oligomerization zone. The recycle of the cycloparaffins extends the catalyst activity and improves the catalyst life. Cyclohexane provides an excellent solvent for removing deposits from the catalyst with chemical inertness to the process and a boiling range that allows its essentially complete recovery when producing nonenes and higher olefins from propylene feeds.

Mitigation of catalyst inhibition in olefin polymerization

This disclosure relates to a process for polymerization comprising providing a recycle stream, wherein the recycle stream comprises one or more C 6 to C 12 conjugated or non-conjugated diene monomers and one or more C 1 to C 40 oxygenates. The recycle stream is contacted with an adsorbent bed to produce a treated recycle stream; wherein the adsorbent bed comprises at least two adsorbents to remove quenching agent and C 1 to C 40 oxygenates.

Mitigation of catalyst inhibition in olefin polymerization

Mitigation of catalyst inhibition in olefin polymerization

This disclosure relates to a process for polymerization comprising providing a recycle stream, wherein the recycle stream comprises one or more C6 to C12 conjugated or non- conjugated diene monomers and one or more C1 to C40 oxygenates. The recycle stream is contacted with an adsorbent bed to produce a treated recycle stream; wherein the adsorbent bed comprises at least two adsorbents to remove quenching agent and C1 to C40 oxygenates.

Genotyping by next-generation sequencing

Provided herein is technology relating to genotyping and particularly, but not exclusively, to methods for genotyping one or more organisms by genome sequencing.

Genotyping by next-generation sequencing

Provided herein is technology relating to genotyping and particularly, but not exclusively, to methods for genotyping one or more organisms by genome sequencing.

Dosage form comprising liquid formulation

A dosage form is disclosed comprising a drug formulation that self-emulsifies in said dosage form.

Controlled release liquid active agent formulation dosage forms

Controlled release of liquid, active agent formulations is provided by dispersing porous particles containing the liquid active agent formulation in osmotic, push-layer dosage forms. The dosage forms may provide for continuous or pulsatile delivery of active agents.

Limiting system for a vehicle suspension component

A damper assembly is disclosed that includes a tubular member, a rod, a primary piston, a secondary piston, and a seal. The tubular member includes a sidewall and a cap positioned at an end of the sidewall. The sidewall and the cap defining an inner volume. The rod extends within the inner volume of the tubular member. The primary piston defines a contact surface and is positioned within the inner volume and coupled to an end of the rod. The secondary piston defines a central aperture and a channel. Engagement of the primary piston and the secondary piston forms a flow conduit between the channel and the contact surface. The seal is disposed between an outer surface of the secondary piston and the sidewall such that a flow path is formed through the central aperture and the flow conduit.

Differentiated routing system and method

A differentiated routing system is provided for routing a communication service according to an access point of a subscriber terminal to a first network domain. The system includes a computing system executing a core routing engine (CRE) that receives a request for a communication service from the subscriber terminal. When the communication service is to be routed to a second network domain, the CRE identifies an access point at which the subscriber terminal accesses the first network domain, includes a tag in the request according to the identified access point. The tag includes information to be used by the second network domain for routing the communication service. The CRE then transmits the request to the second network domain.

Hydrocodone therapy

A hydrocodone composition, a hydrocodone dosage form, and a method of administering hydrocodone are disclosed and indicated for hydrocodone therapy.

Sealed articulating camera for a communication device

An improved seal assembly for an articulating camera (102) is provided in a communication device (100). The articulating camera (102) a coiled flex circuit (208) and pivot housing (110). The coiled flex circuit (208) provides for range of motion. The coiled flex circuit (208) has a flex extension (218) that threads through a barrel hinge (214) of the pivot housing (110). The barrel hinge (214) and flex extension (218) are sealed via a single seal (306) having a circumferential seal (312) and pocket (308) thereby allowing the coiled flex circuit (208) to continue to provide range of rotation within the pivot housing (110).

Nucleic acid molecules encoding multiple start codons and histidine tags

Compositions and methods for identifying nucleotide fragments that contain an open reading frame are provided. Compositions comprise a nucleotide sequence that encodes, in each of the three possible reading frames, an ATG start codon and a histidine tag, and vectors comprising such a nucleotide sequence. The vectors may be provided with cloning sites for insertion of nucleotide sequences of interest 5′ or 3′ to the 3-frame His-tag DNA sequence. Vectors also are provided with cloning sites for inserting nucleotide sequences of interest 3′ of the ATG start codon and 5′ of the 3-frame His-tag DNA sequence.

Oral osmotic device for delivering nicotine

An osmotic device (10) for the controlled systemic delivery of nicotine through an oral mucosal membrane of a human patient is disclosed. The device (10) has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device (10) comprises a semipermeable wall (12) surrounding a compartment (13) containing a nicotine salt (14) and optionally an alkaline salt which is capable of reacting with the nicotine salt in the presence of water to form nicotine base. The conversion of nicotine salt to nicotine base may take place within the device (10) and/or outside the device and in the patient's mouth. Nicotine base and/or salt is delivered from the compartment (13) through a passageway (17) in the wall (12). The nicotine salt exhibits good stability and shelf life while the nicotine base exhibits excellent absorption through oral mucosal membranes.

Retainer systems for ground engaging tools

Disclosed are various exemplary embodiments of a lock for a ground engaging tool. In one exemplary embodiment, the lock may include an upper portion having a tool interface configured to receive a tool for applying torque about a lock rotation axis, a lower portion including a base located opposite the tool interface along the lock rotation axis, and an insert layer positioned between the upper portion and lower portion. The insert layer may be configured to allow the upper portion to move relative to the lower portion without shearing when torque is applied to the tool interface of the upper portion.

Directed evolution of enzymes and antibodies

The invention relates to methods of selecting proteins, out of large libraries, having desirable characteristics. Exemplified are methods of expressing enzymes and antibodies on the surface of host cells and selecting for desired activities. These methods have the advantage of speed and ease of operation when compared with current methods. They also provide, without additional cloning, a source of significant quantities of the protein of interest.

Device and method for providing a barrier to unwanted penetration of finishing materials

A barrier device for preventing unwanted penetration of finishing materials from one surface onto another. The barrier device is particularly useful to protect one surface from unwanted penetration of paint or varnish while the adjacent surface is coated. The barrier device includes a flexible sheet having a substantial width and a narrower strip capable of retaining an impression. The strip and sheet are applied to a textured surface by pressing the strip onto the surface with sufficient force such that the strip material retains an impression of the texture.

Oral osmotic device with hydrogel driving member

An osmotic device for delivering a beneficial drug, such as an anti-fungal, into the mouth of a human patient is disclosed. The device has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device comprises a wall surrounding a compartment housing a layer of an agent that is insoluble to very soluble in aqueous biological fluid, e.g., saliva, and a layer of a fluid swellable, hydrophilic polymer. A passageway in the wall connects the agent with the exterior of the device. The wall is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the hydrophilic polymer. In one embodiment the beneficial agent has a different color than the hydrophilic polymer. The wall is sufficiently translucent to permit the patient to see the amount of drug/beneficial agent remaining to be delivered. Marking lines may be provided on the wall indicating the amount of drug/agent which has been delivered and/or the amount remaining to be delivered.

System for and method of reducing or eliminating leakage with a vibrating seal

The present invention includes a sealing mechanism for use in a cartridge having a roller having an undulant annular channel and a flexible seal having a follower where the follower is configured to engage the undulant annular channel. Rotation of the roller induces a laterally reciprocating motion of the flexible seal with respect to the roller. Another embodiment of the present invention includes a method of reducing toner leakage in a cartridge comprising the steps of engaging a follower of a flexible seal within an undulant annular channel formed in a roller and rotating the roller to induce a laterally reciprocating motion in the flexible seal. When toner is applied to the roller in the vicinity of the flexible seal, the laterally reciprocating motion of the flexible seal sweeps toner in a direction away from the undulant annular channel.

Grain bagging machine and method

Plant genes involved in nitrate uptake and metabolism

The present invention relates nucleic acid molecules that are modulated (e.g., upregulated) by nitrogen in corn, to proteins or polypeptides encoded by these nucleic acid molecules, and promoters of these nucleic acid molecules. The present invention relates to a nucleic acid construct having a nucleic acid molecule that is modulated by nitrogen in corn, as well as to expression systems, host cells, plants, and plant seeds having the nucleic acid construct. The present invention also relates to a method of expressing the nucleic acid molecule that is modulated by nitrogen in a plant by growing a transgenic plant or a plant grown from a transgenic seed transformed with the construct. The present invention further relates to an isolated DNA promoter that can be used to direct nitrogen-regulated expression of an isolated nucleic acid in plants.

Plant genes involved in nitrate uptake and metabolism

The present invention relates nucleic acid molecules that are modulated (e.g., upregulated) by nitrogen in corn, to proteins or polypeptides encoded by these nucleic acid molecules, and promoters of these nucleic acid molecules. The present invention relates to a nucleic acid construct having a nucleic acid molecule that is modulated by nitrogen in corn, as well as to expression systems, host cells, plants, and plant seeds having the nucleic acid construct. The present invention also relates to a method of expressing the nucleic acid molecule that is modulated by nitrogen in a plant by growing a transgenic plant or a plant grown from a transgenic seed transformed with the construct. The present invention further relates to an isolated DNA promoter that can be used to direct nitrogen-regulated expression of an isolated nucleic acid in plants.

Plant genes involved in nitrate uptake and metabolism

The present invention relates nucleic acid molecules that are modulated (e.g., upregulated) by nitrogen in corn, to proteins or polypeptides encoded by these nucleic acid molecules, and promoters of these nucleic acid molecules. The present invention relates to a nucleic acid construct having a nucleic acid molecule that is modulated by nitrogen in corn, as well as to expression systems, host cells, plants, and plant seeds having the nucleic acid construct. The present invention also relates to a method of expressing the nucleic acid molecule that is modulated by nitrogen in a plant by growing a transgenic plant or a plant grown from a transgenic seed transformed with the construct. The present invention further relates to an isolated DNA promoter that can be used to direct nitrogen-regulated expression of an isolated nucleic acid in plants.

Plant genes involved in nitrate uptake and metabolism

The present invention relates nucleic acid molecules that are modulated (e.g., upregulated) by nitrogen in corn, to proteins or polypeptides encoded by these nucleic acid molecules, and promoters of these nucleic acid molecules. The present invention relates to a nucleic acid construct having a nucleic acid molecule that is modulated by nitrogen in corn, as well as to expression systems, host cells, plants, and plant seeds having the nucleic acid construct. The present invention also relates to a method of expressing the nucleic acid molecule that is modulated by nitrogen in a plant by growing a transgenic plant or a plant grown from a transgenic seed transformed with the construct. The present invention further relates to an isolated DNA promoter that can be used to direct nitrogen-regulated expression of an isolated nucleic acid in plants.

Plant genes involved in nitrate uptake and metabolism

The present invention relates nucleic acid molecules that are modulated (e.g., upregulated) by nitrogen in corn, to proteins or polypeptides encoded by these nucleic acid molecules, and promoters of these nucleic acid molecules. The present invention relates to a nucleic acid construct having a nucleic acid molecule that is modulated by nitrogen in corn, as well as to expression systems, host cells, plants, and plant seeds having the nucleic acid construct. The present invention also relates to a method of expressing the nucleic acid molecule that is modulated by nitrogen in a plant by growing a transgenic plant or a plant grown from a transgenic seed transformed with the construct. The present invention further relates to an isolated DNA promoter that can be used to direct nitrogen-regulated expression of an isolated nucleic acid in plants.

Streptococcus pneumoniae polynucleotides and sequences

The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae , polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.

Formulation and dosage form for increasing oral bioavailability of hydrophilic macromolecules

A formulation and dosage form for enhancing the bioavailability of orally administered hydrophilic macromolecules includes a permeation enhancer, a hydrophilic macromolecule, and a carrier such as a nonionic surfactant that exhibits in-situ gelling properties. The formulation is delivered within the GI tract as a liquid having at least some affinity for the surface of the GI mucosal membrane. Once released, it is believed that the liquid formulation spreads across one or more areas of the surface of the GI mucosal membrane, where the carrier of the formulation then transitions into a bioadhesive gel in-situ. As a bioadhesive gel, the formulation presents the hydrophilic macromolecule and the permeation enhancer at the surface of the GI mucosal membrane at concentrations sufficient to increase absorption of the hydrophilic macromolecule through the GI mucosal membrane over a period of time. A dosage form incorporates the formulation and may be designed to provide the controlled release of the formulation within the GI tract over a desired period of time.

Extended release dosage form

Flow controller configurations for an active agent delivery device

The present invention is directed to an oral active agent delivery system comprising improved flow controllers. A hollow tubular member (10) containin g the active agent formulation and having a fluid passing controller (14) is placed at one end (16) into a fluid and at a second end (18) into a patient' s mouth. The active agent is delivered when the patient sips on the end of the chamber. The improved controllers prevent leakage of the active agent formulation.

Dosage form for administering a drug to effect circadian therapy

An osmotic device (10) is disclosed that comprises a first and second means that act together to provide a drug-free interval prior to the delivery of a drug (15) from inside the device (10). The first means slows the passage of fluid through wall (12) into device (10), and the second means in the device delays the delivery of drug (16) from device (10).

Dosage form with improved delivery capability

ABSTRACT A dosage form is disclosed comprising a wall surrounding a compartment housing a first layer comprising a drug formulation, a middle layer comprising a hydrophobic composition, and a third layer comprising a hydrophilic composition.

Antiviral medication

A pharmaceutical composition comprising a liquid antiviral formulation is disclosed. Additionally, a dosage form and a method for administering an antiviral pharmaceutical composition are disclosed.

Dosage form for administering drug in liquid formulation

A dosage form (10) is disclosed for de-livering drug (22) in a non-aqueous carrier to a biological environment of use.

MULTIUNITARY SYSTEM FOR PROVIDING SUBSTANCES TO A SURROUNDING ENVIRONMENT

Osmotic device with high drug loading and delayed activation of drug delivery

The present invention is directed to a fluid-imbibing drug delivery device which is useful for the initial delayed delivery of an active agent formulation to a fluid environment of use, the initial delay period to startup or activation being of a predetermined length of time. The dispensing device is formed of a first and second housing that are in reversibly sliding telescoping arrangement with each other. The first housing contains the active agent formulation and has an aspect ratio less than 1. The housings are preferably ovoid in shape.

DEVICE FOR PROVIDING A DRUG AT THE COLON

Uniform drug delivery therapy

The invention disclosed pertains to a novel delivery system comprising an agent formulation and means for dispensing the agent formulation from the delivery system.

Volume efficient controlled release dosage form

OSMOTIC DEVICE FOR DELIVERING A MEDICAMENT AT COLON LEVEL

DISPOSITIF OSMOTIQUE POUR APPORTER UN MEDICAMENT AU NIVEAU DU COLON. LE DISPOSITIF COMPREND UNE PAROI STRATIFIEE 12 ENTOURANT UN COMPARTIMENT 15 CONTENANT UN MEDICAMENT, AVEC UN PASSAGE 13 PERCE DANS LA PAROI POUR RELIER LE COMPARTIMENT A L'EXTERIEUR. LA PAROI 12 COMPREND TROIS COUCHES, UNE COUCHE INTERNE 16 SEMI-PERMEABLE, UNE COUCHE MOYENNE 17 CONTENANT UN SEL D'ACIDE GRAS, ET UNE COUCHE ENTERIQUE 22 EXTERNE. APPLICATION: ADMINISTRATION ORALE D'UN MEDICAMENT, LOCAL OU GENERAL, ABSORBE PAR LE COLON. OSMOTIC DEVICE FOR DELIVERING A MEDICINE TO THE LEVEL OF THE COLON. THE DEVICE INCLUDES A LAMINATED WALL 12 SURROUNDING A COMPARTMENT 15 CONTAINING A MEDICINAL PRODUCT, WITH A PASSAGE 13 BORED IN THE WALL TO CONNECT THE COMPARTMENT TO THE EXTERIOR. WALL 12 CONSISTS OF THREE LAYERS, A SEMI-PERMEABLE INNER LAYER 16, A MIDDLE LAYER 17 CONTAINING A FATTY ACID SALT, AND AN OUTER 22 INNER LAYER. APPLICATION: ORAL ADMINISTRATION OF A MEDICINE, LOCAL OR GENERAL, ABSORBED BY THE COLON.

MULTIUNITARY SYSTEM FOR PROVIDING SUBSTANCES TO A SURROUNDING ENVIRONMENT

Système d'apport de substances à un milieu liquide environnant, qui peut apporter à ce milieu plusieurs unités ou éléments séparés 24, 26, 28, 30 et 32 contenant un médicament suivant tout programme ou modèle d'apport voulu. System for delivering substances to a surrounding liquid medium, which can supply this medium with several units or separate elements 24, 26, 28, 30 and 32 containing a drug according to any desired delivery schedule or pattern.

DOSAGE FORM FOR IMPROVED SUPPLY OF SUBSTANCES TO A MEDIUM

Osmotic system for the controlled supply of haloperidol

The invention relates to an osmotic system for the controlled supply of haloperidol to a medium for its application at a controlled rate over an extended period of time. The system is made in the form of a device 10 containing a semi-permeable wall 14 which surrounds and defines a compartment 15 in which haloperidol is present in combination with a di- or tricarboxylic acid which increases the solubility of the haloperidol and facilitates its release via a passage 12. Field of application: haloperidol therapy.

CONSTANT AND PULSED RELEASE DELIVERY SYSTEM OF SUBSTANCES TO A SURROUNDING ENVIRONMENT

ON DECRIT UN SYSTEME D'APPORT OSMOTIQUE10 POUR LA LIBERATION D'UN AGENT UTILE16 A UNE VITESSE CONTROLEE ET CONSTANTE, MODULEE PAR UNE LIBERATION PULSEE DE L'AGENT UTILE DANS LE MILIEU D'UTILISATION. AN OSMOTIC10 DELIVERY SYSTEM FOR THE RELEASE OF A USEFUL AGENT16 AT A CONTROLLED AND CONSTANT SPEED, MODULATED BY A PULSED RELEASE OF THE USEFUL AGENT INTO THE ENVIRONMENT OF USE.

OSMOTIC DEVICE FOR THE RELEASE OF MATERIALS IN A MEDIA FOR USE

Oral osmotic device for delivering nicotine

An osmotic device (10) for the controlled systemic delivery of nicotine through an oral mucosal membrane of a human patient is disclosed. The device (10) has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device (10) comprises a semipermeable wall (12) surrounding a compartment (13) containing a nicotine salt (14) and optionally an alkaline salt which is capable of reacting with the nicotine salt in the presence of water to form nicotine base. Nicotine base is delivered from the compartment (13) through a passageway (17) in the wall (12). The nicotine salt exhibits good stability and shelf life while the nicotine base exhibits excellent absorption through oral mucosal membranes.

DOSAGE FORM FOR IMPROVED SUPPLY OF SUBSTANCES TO A MEDIUM

UNE FORME DE DOSAGE 20 COMPORTANT UNE PAROI 22 QUI ENTOURE UN COMPARTIMENT 25 RENFERMANT UNE PREMIERE COUCHE 26 QUI COMPREND UNE FORMULE DE MEDICAMENT, UNE SECONDE COUCHE INTERMEDIAIRE 27 COMPRENANT UNE COMPOSITION HYDROPHOBE ET UNE TROISIEME COUCHE 28 COMPRENANT UNE COMPOSITION HYDROPHILE. CE DISPOSITIF PEUT SERVIR NOTAMMENT A L'ADMINISTRATION PROLONGEE DE MEDICAMENTS, EN PARTICULIER DANS L'APPAREIL GASTRO-INTESTINAL. A DOSAGE FORM 20 INCLUDING A WALL 22 SURROUNDING A COMPARTMENT 25 CONTAINING A FIRST LAYER 26 WHICH INCLUDES A MEDICINAL FORMULA, A SECOND INTERMEDIATE LAYER 27 INCLUDING A HYDROPHOBIC COMPOSITION AND A THIRD LAYER 28 INCLUDING A HYDROPHOBIC COMPOSITION. THIS DEVICE CAN BE USED IN PARTICULAR FOR LONG-TERM ADMINISTRATION OF MEDICINAL PRODUCTS, IN PARTICULAR IN THE GASTROINTESTINAL SYSTEM.

Compositions and dosage forms for enhanced absorption of 3-amino-n-butyl-phosphinic acid

Disclosed are substances, compositions, dosage forms and methods relating to drugs including 3-aminopropyl-n-butyl-phosphinic acid; structural homologs thereof; 3-aminopropyl-n-butyl-phosphinic acid complexes; complexes that comprise structural homologs of 3-aminopropyl-n-butyl-phosphinic acid; pharmaceutically acceptable salts of 3-aminopropyl-n-butyl-phosphinic acid or structural homologs thereof; and mixtures of the above.

Power converter with dual ring network control

A method for providing electric power to a power system includes receiving, at a slave node of a power converter having a plurality of slave nodes, a first synchronization signal via a first communication channel, the first synchronization signal purporting to represent a master timing characteristic of a master control node of the converter; receiving, at the slave node of the converter, a second synchronization signal via a second communication channel, the second synchronization signal purporting to represent a master timing characteristic of the master control node of the converter; synchronizing an internal timing characteristic of the slave control node with the master timing characteristic of the master control node using the first synchronization signal; determining that the first synchronization signal is invalid; and synchronizing an internal timing characteristic of the slave control node with the master timing characteristic of the master control node using the second synchronization signal.

Multiple flow path device for oral delivery of discrete units

CONSTANT FLOW AND PULSED RELEASE DELIVERY SYSTEM OF SUBSTANCES TO A SURROUNDING MEDIUM

Power conditioning architecture for a wind turbine

A wind turbine 36 has a back-to-back AC/DC/AC power electronic converter chain in which the grid side converter 48 is connected in series with DFIG stator windings 64. The machine side converter 56 is fed from the rotor windings 54 of the DFIG 44. Series connection of the grid side converter 48 enables voltage sag ride-through capability via control of the stator flux. In the event of a grid voltage sag, the series converter allows for a controlled response in the stator flux and electromagnetic shaft torque, protects the machine side converter and enables continued power delivery to the grid.

Method of administration for time-varying patterns of drug delivery

Clustered wellhead trunkline protection and testing system with esp speed controller and emergency isolation valve.

Los sistemas y procesos de la presente invención incluyen controladores de accionamiento de velocidad variable de ESP que funcionan en conjunto con un solucionador lógico de seguridad, sensores de presión y una válvula de aislamiento de emergencia para llevar a cabo un ensayo funcional del sistema completo de protección de la línea troncal de la boca de pozo sin interrumpir la producción.

Clustered wellhead trunkline protection and testing system with esp speed controller and emergency isolation valve

The systems and processes of the present invention includes ESP variable speed drive controllers that function in conjunction with a safety logic solver, pressure sensors, and an emergency isolation valve to perform a functional test of the complete wellhead trunkline protection system without interruption of production.

Osmotic device with delayed activation of drug delivery and complete drug release

The present invention is directed to a fluid-imbibing drug delivery device which is useful for the initial delayed delivery of an active agent formulation to a fluid environment of use, the initial delay period to startup or activation of the device being of a predetermined length of time. The delivery of the agent formulation from the dispensing device is continued until essentially all of the active agent formulation is delivered as a result of the expansion of an expansion agent in the active agent delivery chamber.

Osmotic drug delivery devices with hydrophobic wall materials

Osmotically driven drug delivery devices with walls of porous hydrophobic materi-al as the sole diffusion-limiting wall component are disclosed. Despite pores which are considerably larger than the molecular dimensions of non-volatile species in the interior of the device, despite pores which by their hydrophobic character do not permit the pas-sage of liquid water, and despite the absence of a cellulosic semipermeable membrane, the devices absorb water by osmosis without loss of the non-volatile species, and function in a manner analogous to osmotic pumps of the prior art. By permitting the use of hydrophob-ic substances as the wall material, the invention permits the device to be constructed en-tirely from biodegradable materials.

Banded prolonged release active agent dosage form

The present invention is directed to an active agent dosage form which is useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a matrix that has on its surface two or more insoluble bands. The invention is also directed to the method for making the active agent dosage form.

Dosage form, process of making and using same

The invention disclosed pertains to a dosage form comprising an agent formulation comprising drug and pharmaceutical carrier of cooperating particle size and means for dispensing the agent formulation from the dosage form.

Tool retention system

A retention system (20) is provided for use with a ground engaging tool (14). The tool retention system may have a spool (26) with an elongated channel (60), and a collar (68) dividing the elongated channel into a first portion and a second portion. The tool retention system may also have a fastener (32) disposed within the elongated channel and passing through the collar. The fastener may have a head located within the first portion and a threaded shank located within the second portion. The tool retention system may further have a resilient member (34) disposed between the head of the fastener and the collar, and a slider (30) threadingly engaged with the threaded shank and configured to slide within the second portion of the elongated channel as the fastener is rotated.

Apparatus for wellhead high integrity protection system

A system for protecting piping downstream of a wellhead includes an inlet connected to the wellhead and an outlet connected to downstream piping. Two sets of series-connected surface safety valves are in a parallel fluid flow relation to each other and in fluid communication with the inlet. Two vent control valves, which are in fluid communication with each other, each of the two series-connected safety valves and the inlet and outlet of the system, are intermediately connected to the safety valves. Each vent control valve is in fluid communication with a vent line for venting process pressure between surface safety valves through the outlet control valve based on a signal-generating safety logic solver having preprogrammed safety and operational protocols and pressure sensing transmitters attached upstream of the outlet control valve Independent, tight shut-off tests of each series-connected surface safety valve set closes all valves upon electrical or hydraulic failure.

Dosage form for time-varying patterns of drug delivery

A dosage form (10) is disclosed that comprises means (18) inside the dosage form for providing a substantially drug-free interval before dosage form (10) delivers a drug (15) from inside dosage form (10). The dosage form (10) in an embodiment comprises a drug (15) on the exterior of dosage form (10), which drug is available for immediate delivery.

Apparatus and method for vitrification of contaminated soil or waste

A process for melting material to be treated includes placing material to be treated in a container that may include an insulating lining, heating the material to be treated and melting the material to be treated, preferably allowing the melted material to cool to form a vitrified and/or crystalline mass, and disposing of the mass. The mass is either disposed while contained in container or removed from container after cooling and disposed. Insulating lining may comprise one or more layers of a thermal insulating material, one or more layers of refractory material, or a combination thereof. The material to be treated may be heated by placing at least two electrodes in the material to be treated and passing a current between the electrodes, or alternatively, by placing at least one heating element in the material to be treated and passing heat into the material to be treated.

Dosage form using liquid formulation

Formulation & dosage form for the controlled delivery of therapeutic agents

The present invention includes a formulation and controlled release dosage form that enable the controlled release of therapeutic agents showing reduce d absorption in the lower gastrointestinal tract. The formulation of the prese nt invention includes a therapeutic agent that exhibits greater absorption in t he upper GI tract than in the lower GI tract and a permeation enhancer, which serves to increase absorption of the therapeutic agent in the lower GI tract . The formulation of the present invention further includes a carrier that allows the formulation to transition to a bioadhesive gel in situ after the formulation is dispensed within the GI tract and has had some opportunity to reach the surface of the GI mucosal membrane. The bioadhesive gel formed by the formulation of the present invention works to present effective concentrations of both the therapeutic agent and the permeation enhancer at the surface of the GI mucosal membrane over a period. The controlled release dosage form of the present invention is designed to deliver the formulation of the present invention at a desired release rate or release rate profile over a desired period of time.

Methods for alignment utilizing an optical reference

Chlorpheniramine therapie.

Device and method for protecting a wellhead

Measuring an appearance property of a surface using a spatially under-sampled bidirectional reflectance distribution function

An apparatus for measuring a spatially under-sampled Bidirectional Reflectance Distribution Function (BRDF) of a surface. The apparatus may comprise a first light source directed to illuminate the surface from a first illumination direction, and a plurality of sensors positioned to receive light reflected by the surface. The plurality of sensors may comprise first, second and third sensors positioned to receive light reflected by the surface in first, second and third non-coplanar directions. In various embodiments, the apparatus may also comprise a computer in communication with the plurality of sensors. The computer is configured to convert light sensed by the plurality of sensors into a first appearance property of the surface considering the first, second, and third reflectance directions.

Improved method of melting solid materials

A method of melting solid materials while controlling melt shape, without the expenditure of energy to melt unwanted quantities of surrounding materials, and an apparatus to effect the method. The method comprises the use of a planar starter path (48) between the electrodes (40) so as to initiate melting and/or vitrification in a plane rather than in a discrete linear path between the electrodes (40). Because melting is initiated along a significant portion of the linear dimension of the electrodes (40), creating a melted zone that is deeper than it is thick, the aspect ratio (depth "Y"/width "Z") of the melted mass (138) is greater than 1.0.

Controlled delivery dosage form of tramadol and gabapentin

Disclosed are substances, compositions, dosage forms and methods that comprise tramadol and substances that comprise gabapentin.

Adaptive high integrity ESD system

A valve integrity manager is coupled with a servo or stepper motor to direct micro stroke testing of emergency shutdown valves. During testing, the system orders a closure of 20-25% of an emergency shutdown valve, providing data that either confirms the operability of the valve or a deficiency, while minimizing any effect on process variables.

Tool retention system

A retention system (20) is provided for use with a ground engaging tool (14). The tool retention system may have a spool (26) with an elongated channel (60), and a collar (68) dividing the elongated channel into a first portion and a second portion. The tool retention system may also have a fastener (32) disposed within the elongated channel and passing through the collar. The fastener may have a head located within the first portion and a threaded shank located within the second portion. The tool retention system may further have a resilient member (34) disposed between the head of the fastener and the collar, and a slider (30) threadingly engaged with the threaded shank and configured to slide within the second portion of the elongated channel as the fastener is rotated.

DOSAGE FORM FOR MEDICINAL DELIVERY WITH DIFFERENT PATTERNS

Wood tracking by identification of surface characteristics

A "Woodprint.TM." characterization and identification technique employs cameras (16), fighting (14), camera interface hardware (18), a computer (20), and/or image processing software to collect and analyze surface characteristics of pieces of wood (8) to track them through an automated production process in real-time with information that is specific to each wood piece (8), such as what machining is required, its value, and/or its destination. When a wood piece (8) reaches a point in the production process where a decision is required, its unique identity is used to retrieve appropriate information previously determined and assigned to the wood piece (8).

Melt blend dispersions comprising a low water solubility drug and an ethylene oxide-propylene oxide block copolymer

The present invention relates to compositions and methods for enhancing the dissolution and biovailibilty of beneficial agents with low water solubility.

ACTIVATION BY MOISTURE OF A TRANSDERMIC PHARMACY SUPPLY SYSTEM.

UN DISPOSITIVO DE SUMINISTRO DE DROGA DIFUSIONAL SE DESCRIBE PARA SERIES DE EFECTO TERAPEUTICO APLAZADO Y PARA SUMINISTRO DE AGENTES TERAPEUTICOS, EN PATRONES TEMPORALES PREDETERMINADOS DE MODO OPTIMO. SE PROVEEN MEDIOS DE RETRASO ENTRE EL DEPOSITO DEL AGENTE Y LA SUPERFICIE A TRAVES DE LA CUAL EL AGENTE SE SUELTA POR DIFUSION PARA RETRASAR LA PUESTA EN LIBERTAD DEL AGENTE POR RAZON TERAPEUTICA PARA TIEMPOS PREDETERMINADOS DESPUES DE LA APLICACION. MEDIOS APROPIADOS INCLUYEN UNA MEMBRANA DE RETRASO DISPUESTA ENTRE LA SUPERFICIE DE PUESTA EN LIBERTAD Y EL DEPOSITO DE AGENTE, CUYA MEMBRANA SE LIBERA PREFERIBLEMENTE DE AGENTES INDISOLUBLES Y/O ES INICIALMENTE IMPERMEABLE AL AGENTE Y DE ALLI EN ADELANTE LLEGA A SER PERMEABLE. UNA O MAS CAMARAS DE AGENTE DEFINIDAS POR UNA O MAS DE DICHAS MEMBRANAS PUEDE PROVEERSE, POR DONDE LOS AGENTES SON SOLTADOS EN UNOS PATRONES DE TIEMPO PREDETERMINADO POR RAZONES DE LIBERACION OPTIMA. LA PERMEABILIDAD RETRASADA FACILITA PERIODOS DE FRACASO PROGRAMADO PARA OBTENER UNA SECUENCIAL Y CONCURRENTE APLICACION DE DISPOSITIVOS PARA LA ADMINISTRACION DE DROGAS, TALES COMO NITRATOS, A PACIENTES QUE DEBAN DESARROLLAR UNA TOLERANCIA EN LA ADMINISTRACION CONTINUA EN PERIODOS DE TIEMPO EXTENDIDOS. A DIFFUSIONAL DRUG SUPPLY DEVICE IS DESCRIBED FOR POSTPONED THERAPEUTIC EFFECT SERIES AND FOR SUPPLY OF THERAPEUTIC AGENTS, IN OPTIMALLY DEFAULT TEMPORARY PATTERNS. DELAY MEANS ARE PROVIDED BETWEEN THE AGENT DEPOSIT AND THE SURFACE THROUGH WHICH THE AGENT IS RELEASED BY DIFFUSION TO DELAY THE AGENT'S RELEASE FOR THERAPEUTIC REASON AFTER APPLICATION. APPROPRIATE MEANS INCLUDE A DELAY MEMBRANE ARRANGED BETWEEN THE SURFACE OF RELEASE AND THE AGENT DEPOSIT, WHICH MEMBRANE IS PREFERABLY RELEASED FROM INDISOLVABLE AGENTS AND / OR IS INITIALLY WATERPROOF TO THE AGENT AND THEREFORE REALLY FORWARD. ONE OR MORE AGENT CHAMBERS DEFINED BY ONE OR MORE OF THESE MEMBRANES CAN BE PROVIDED, WHERE THE AGENTS ARE RELEASED IN A TIME PATTERN DEFAULT FOR REASONS OF ...

A sealing mechanism for a toner cartridge

Patent CH671696A5

Method of fabricating a banded prolonged release active agent dosage form

The present invention is directed to an active agent dosage form and methods of its fabrication which is useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a matrix that has on its surface one or more insoluble bands located in complementary grooves. The invention is also directed to articles of manufacture, methods and systems for fabricating the active agent dosage form.

Coating suspensions (comprising osmopolymers, osmagents) for forming an expandable osmotic composition in controlled release dosage forms as well as the corresponding method for providing this osmotic coating

The present invention includes an expandable osmotic layer and a coating suspension for providing an expandable osmotic layer, both of which are useful for the manufacture of controlled release dosage forms. The expandable osmotic layer of the present invention may be produced using the coating suspension of the present invention. Advantageously, the coating suspension of the present invention can be used to coat expandable osmotic layers under both wet and dry process conditions without sacrificing the quality of the expandable osmotic layers produced, and therefore provides a relatively robust coating suspension that facilitates commercial production of controlled release dosage forms including a coated expandable osmotic layer.

Position dependent damper for a vehicle suspension system

A damper assembly for a vehicle suspension system includes a primary damper and a secondary damper. The secondary damper includes a housing having a wall that at least partially surrounds at least a portion of the primary damper, the volume between the wall and the primary damper defining a chamber, and the wall defines an aperture. The secondary damper also includes a piston positioned within the chamber, a conduit defining a flow path that includes the aperture, and a valve disposed along the flow path. The secondary damper is configured to provide a damping force that varies based on the position of the piston within the chamber.

Moisture activation of transdermal drug delivery system

ABSTRACT OF THE DISCLOSURE A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reser-voir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are re-leased in a predetermined temporal patterns at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continous administra-tion over extended time periods.

Power converter with dual ring network control

A method for providing electric power to a power system includes receiving, at a slave node of a power converter having a plurality of slave nodes, a first synchronization signal via a first communication channel, the first synchronization signal purporting to represent a master timing characteristic of a master control node of the converter; receiving, at the slave node of the converter, a second synchronization signal via a second communication channel, the second synchronization signal purporting to represent a master timing characteristic of the master control node of the converter; synchronizing an internal timing characteristic of the slave control node with the master timing characteristic of the master control node using the first synchronization signal; determining that the first synchronization signal is invalid; and synchronizing an internal timing characteristic of the slave control node with the master timing characteristic of the master control node using the second synchronization signal.

DOSERINGSFORM FOER GIVANDET AV ETT CEILING MODEL FOER REALIZATION AV DYGNTERAPI

Dosage form with means for governing rate of gas formation

ABSTRACT An osmotic device is disclosed comprising a release rate controlling wall that surrounds a carbon dioxide generating compound.

Methods for melting of materials to be treated

A process for melting material to be treated includes placing material to be treated in a container that may include an insulating lining, heating the material to be treated and melting the material to be treated, preferably allowing the melted material to cool to form a vitrified and/or crystalline mass, and disposing of the mass. The mass is either disposed while contained in container or removed from container after cooling and disposed. Insulating lining may comprise one or more layers of a thermal insulating material, one or more layers of refractory material, or a combination thereof. The material to be treated may be heated by placing at least two electrodes in the material to be treated and passing a current between the electrodes, or alternatively, by placing at least one heating element in the material to be treated and passing heat into the material to be treated.

A composition containing polycaprolactone and poly(alkylene oxide) and dosage form having injection-molded membrane comprising polycaprolactone

The invention relates to a membrane, which can be injection moulded, comprising polycaprolactone and at least one of a poly (alkylene oxide), poly (ethylene glycol) or poly (hydroxypropylcellulose).

Grain angle sensor

A grain angle sensor system (40) for measuring grain angle direction of surface fibers of a wood object (26) with respect to at least one of a surface plane direction or a transverse direction, such as a dive angle, or with respect to both the surface plane and transverse direction. The system (40) includes multiple laser diodes (44) and photosensor detectors (52) integrated into an electro-optical assembly (54) that can sequence the firing of the lasers (44) to minimize crosstalk. An exemplary assembly (54) includes an enclosure housing an electronic control board connected to circuit cards containing multiple laser diodes (44) and multiple photosensor detectors (52).

Thermoplastic polymer membranes.

Antidepressant dosage form

The invention pertains to a dosage form (10) and to administering an antidepressant medicament (16) for an extended period of time in a rate-known dose.