Brush box module for chemical mechanical polishing cleaner

Embodiments of the invention generally relate to a method and apparatus for cleaning a substrate. Particularly, embodiments of the invention relate to an apparatus and method for cleaning a substrate using a scrub brush. One embodiment provides a brush box assembly for cleaning a substrate. The assembly comprises a chamber body having a cleaning chamber disposed therein, a rotatable chuck disposed in the cleaning chamber, and an edge cleaner module positioned adjacent the chuck.

Passive millimeter wave differential interference contrast polarimetry

Differential polarization imaging systems include an axicon configured to provide a displacement of ray bundles associated with different image patches. The displaced ray bundles are directed to antenna horns and orthomode transducers so as to provide outputs correspond to orthogonal linear states of polarization (SOPs). The outputs are directed to a differential radiometer so that Stokes parameter differences between image patches can be obtained. The ray bundle displacements can be selected to correspond to a mechanical spacing of antenna horns. In some examples, ray bundle displacement corresponds to a displacement less than the diffraction limit.

Methods and apparatus for pre-chemical mechanical planarization buffing module

The present invention provides methods and apparatus for a pre-CMP semiconductor substrate buffing module. The invention includes a polishing pad assembly adapted to be rotated against a major surface of a substrate; a chuck adapted to hold the substrate and to rotate the substrate against the polishing pad assembly as the polishing pad assembly is rotated; and a lateral motion motor adapted to oscillate the polishing pad assembly laterally across the major surface of the substrate while the polishing pad assembly is rotated against the rotating substrate. Numerous additional features are disclosed.

Inhaler with aperatured porous support element

An inhaler article includes a body extending from a mouthpiece end to a distal end with an endpiece element at the distal end. A capsule cavity is defined within the body and extends a cavity length. An air inlet region is between the endpiece element and the capsule cavity. The air inlet region has an air inlet and an air passageway extending from the air inlet to the capsule cavity. The air passageway has an inner diameter less than an inner diameter of the capsule cavity. A porous support element defines a downstream end of the capsule cavity. The porous support element includes one or more apertures extending the length of the porous support element.

Aerosol generating article comprising a heat source

An aerosol-generating article is provided, including: a fluid guide having proximal and distal ends, and an inner longitudinal region including an inner longitudinal passageway between the distal end and the proximal end thereof, such that fluid can travel from the distal end to the proximal end, the fluid guide including a barrier between the inner and outer longitudinal passageways; a tubular element including a gel or a porous medium or a thread loaded or any combination, the gel or the medium or the thread or the combination includes an active agent, the tubular element having proximal and distal ends and disposed to a distal side of the fluid guide; an aperture to allow fluid to pass to the tubular element and exit the article at the proximal end; a combustible heat source at the distal end of the article; and a cavity between the fluid guide and the tubular element.

Multi-Platen Multi-Head Polishing Architecture

A polishing apparatus includes a plurality of stations supported on a platform, the plurality of stations including at least two polishing stations and a transfer station, each polishing station including a platen to support a polishing pad, a plurality of carrier heads suspended from and movable along a track such that each polishing station is selectively positionable at the stations, and a controller configured to control motion of the carrier heads along the track such that during polishing at each polishing station only a single carrier head is positioned in the polishing station.

Polishing System with In-Sequence Sensor

A polishing apparatus includes a plurality of stations supported on a platform, the plurality of stations including at least two polishing stations and a transfer station, each polishing station including a platen to support a polishing pad, a plurality of carrier heads suspended from and movable along a track such that each polishing station is selectively positionable at the stations, and a controller configured to control motion of the carrier heads along the track such that during polishing at each polishing station only a single carrier head is positioned in the polishing station. 1. A polishing apparatus comprising:five stations supported on a platform and positioned at substantially equal angular intervals around a center of the platform, the five stations including three polishing stations, a transfer station and a metrology station, each polishing station including a platen to support a polishing pad;a plurality of carrier heads suspended from and movable along a track such that each polishing station is selectively positionable at the stations; andan in-sequence metrology system having a probe located in the metrology station.2. The polishing apparatus of claim 1 , wherein the metrology station includes a single probe from the in-sequence metrology system.3. The polishing apparatus of claim 1 , wherein the metrology station includes a plurality of probes from a plurality of in-sequence metrology systems.4. The polishing apparatus of claim 1 , wherein the metrology station is positioned between two of the three polishing stations.5. The polishing apparatus of claim 1 , wherein the metrology station is positioned between the transfer station and a polishing station of the three polishing stations.6. The polishing apparatus of claim 1 , wherein the track is circular.7. A polishing apparatus comprising:a plurality of polishing stations, each polishing station including a platen to support a polishing pad;a plurality of carrier heads held by a support structure ...

Packet multi-cast for memory pool replication

Examples described herein relate to a network interface. In some examples, the network interface is to access data designated for transmission in at least one packet to multiple memory nodes by inclusion of an multicast identifier of a memory node group and transmit the at least one packet to a destination network device, wherein the multicast identifier of the memory node group in the at least one packet is to cause an intermediate network device to multicast the packet to multiple memory nodes. In some examples, a memory node comprises a memory pool that includes one or more of: volatile memory, non-volatile memory, or persistent memory. In some examples, the intermediate network device comprises a switch configured to determine network addresses of memory nodes associated with the multicast identifier of the memory node group.

Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (pcsk9)

The present disclosure relates to novel compounds capable of binding to PCSK9, thereby modulating PCSK9 biological activity. Also provided are compositions comprising these compounds, methods of preparing the compounds, and methods for use of the compounds in the treatment of PCSK9-related conditions and diseases.

Method for the manufacture of susceptor sheet material comprising an aerosol-forming gel and dosing system

The method for the manufacture of a susceptor sheet material comprising an aerosol-forming gel comprises the steps of providing a susceptor sheet material comprising at least one depression on both sides of the susceptor sheet material; and applying aerosol-forming gel to the at least one depression on both sides of the susceptor sheet material. Also a dosing device for the application of an aerosol-forming gel is described.

Atomic Oxygen-Resistant, Low Drag Coatings and Materials

Coatings and materials that are atomic oxygen resistant and have an atomically smooth surface that can reduce drag are disclosed. The coatings and materials can be used on at least a portion of a spacecraft intended to operate in harsh environments, such as stable Earth orbits at about 100 km to about 350 km.

Method to treat lipid dysregulation by modulation of proprotein convertase subtilisin/kexin type 9 (pcsk9) protein activity with small molecule ligands

This invention is related to the field of PCSK9 biology and the composition and methods of use of small molecule ligands for modulation of PCSK9 biological activity. In particular, the invention provides compositions of small molecule compounds that modulate circulating levels of low density lipoproteins by altering the conformation of the protein PCSK9. Binding these small molecule ligands to PCSK9 alters the conformation of the protein, modifying the interaction between PCSK9 and an endogenous low density lipoprotein receptor, and can lead to reduced or increased levels of circulating LDL-cholesterol, High LDL-cholesterol levels are associated with increased risk for heart disease. Low LDL-cholesterol levels may be problematic in other conditions, such as liver dysfunction; thus, there is also utility for small molecule ligands that can raise LDL levels.

Measurement of protein molecular flux rates by quantifying isotopologue abundances in immonium ion using high resolution mass spectrometry

Provided herein are methods for measuring a molecular flux rate proteins and polypeptides based on analysis of isotopologue abundances of immonium ion fragments within a mass isotopomer using a high resolution mass spectrometric measurement. Such methods may be used, inter alia, to calculate a fraction of newly synthesized protein or polypeptide molecules of interest, a replacement rate of target molecules of interest, and/or a rate of breakdown or degradation of target molecules of interest, e.g., based on isotopologue relative abundances.

Composition and methods of use of small molecules as binding ligands for the modulation of proprotein convertase subtilisin/kexin type 9(pcsk9) protein activity

This invention is related to the field of PCSK9 biology and the composition and methods of use of small molecule ligands for modulation of PCSK9 biological activity. In particular, the invention provides compositions of small molecule compounds that modulate circulating levels of low density lipoproteins by altering the conformation of the protein PCSK9. Binding these small molecule ligands to PCSK9 alters the conformation of the protein, modifying the interaction between PCSK9 and an endogenous low density lipoprotein receptor, and can lead to reduced or increased levels of circulating LDL-cholesterol. High LDL-cholesterol levels are associated with increased risk for heart disease. Low LDL-cholesterol levels may be problematic in other conditions, such as liver dysfunction; thus, there is also utility for small molecule ligands that can raise LDL levels.

Negative pressure device having oxygen scavenger and volume reduction

A negative pressure tissue treatment system useful for negative pressure therapy includes a drape, a gasket material, a reactor housing, a reactor, and any fluid connection(s). The drape covers the skin of a patient and maintains negative pressure under the drape. The gasket material cooperates with the drape to define an enclosed volume that is sealed by the gasket material. The reactor housing defines a closed chamber in fluid communication with the enclosed volume, and the re- actor is disposed in the reactor housing. The reactor consumes oxygen from a system volume defined by the enclosed volume, closed chamber, and/or any fluid connection(s). As a result of the oxygen consumption, the system volume is reduced to between about 95% to about 80% of the initial system volume.

Platen Shield Cleaning System

In a chemical mechanical polishing system, a platen shield cleaning assembly is installed on a rotatable platen in a gap between the rotatable platen and a platen shield. The assembly includes a sponge holder attached to the platen and a sponge. The sponge is held by the sponge holder such that an outer surface of the sponge is pressed against an inner surface of the platen shield. 1. An assembly comprising:a rotatable platen;a platen shield surrounding the platen and separated from the platen by a gap;a sponge holder attached to the platen and situated in the gap; anda sponge held by the sponge holder such that an outer surface of the sponge is pressed against an inner surface of the platen shield.2. The assembly of claim 1 , wherein the sponge holder further comprises an adapter configured to be removably secured to the rotatable platen claim 1 , the adapter configured to press the sponge against the inner surface of the platen shield.3. The assembly of claim 2 , wherein the adapter further comprises a latch configured to be removably secured to a plug extending from a platen.4. The assembly of claim 3 , wherein the sponge is pressed against an inner surface of the platen shield by a plurality of springs.5. A platen shield cleaning system comprising:an adapter configured to be removably secured to a platen of a chemical mechanical polishing system; anda sponge holder connected to the adapter and having an outer surface configured to receive a sponge and hold the sponge against an inner surface of a platen shield that surrounds the platen.6. The platen shield cleaning system of claim 5 , wherein the adapter further comprises a latch configured to be removably secured to a plug extending from a platen.7. The platen shield cleaning system of claim 5 , wherein the adapter further comprises a support flange configured to abut a top surface of the platen to prevent the adapter from rotating.8. The platen shield cleaning system of claim 5 , wherein a plurality of springs ...

Corrosion-Resistant TGIC Primer Coating

Methods, formulations, and systems for coating metal substrates are provided. The methods and systems include application of TGIC-based powder coatings that demonstrate excellent corrosion resistance when exposed to outdoor conditions, as demonstrated by cyclic corrosion testing.

Imaging Systems and Related Methods Including Radar Imaging with Moving Arrays or Moving Targets

Imaging systems, including radio frequency, microwave and millimeter-wave arrangements, and related methods are described. According to one aspect, an imaging system includes an antenna array, a position capture system configured to generate position information indicative of locations of one of the antenna array and the target at the first and second moments in time, and wherein the one of the antenna array and the target move between the first and second moments in time, a transceiver configured to control the antenna array to emit electromagnetic energy towards the target and to generate an output that is indicative of the received electromagnetic energy, a data acquisition system configured to generate radar data, processing circuitry configured to process the position information and the radar data to generate image data regarding the target, and an interface configured to use the image data to generate visual images regarding the target.

Two-Coat Single Cure Powder Coating

Methods and systems for coating metal substrates are provided. The methods and systems include sequential application of low flow and high flow powder coatings followed by a single heating step to provide a cured coating. The methods and systems include a marker that allows coating uniformity to be monitored and assessed during application. The described methods provide coatings with optimal surface smoothness and edge coverage.

Fluid logic for regulating restriction devices

Methods and devices are provided for regulating a restriction system. In one exemplary embodiment, a restriction system is provided having a restriction device configured to receive fluid and to form a restriction in a pathway corresponding to an amount of fluid contained therein, at least one fluid reservoir, and a fluid logic system coupled between the restriction device and the at least one fluid reservoir. The fluid logic system is configured to regulate an amount of fluid in the restriction device in response to a fluid pressure acting thereon.

Controlling pressure in adjustable restriction devices

Methods and devices are provided for regulating a hydraulic restriction system including a restriction device. In general, the methods and devices can allow for non-invasive, transient pressure control. The methods and devices can also, in some embodiments, mechanically regulate pressure of the restriction device without using any electrical components that may need to be powered to operate over extended periods of time.

Constant force mechanisms for regulating restriction devices

Methods and devices are provided for regulating a restriction system. In one exemplary embodiment, a restriction system is provided having a restriction device coupled to a port with a fluid disposed in the device, such that the restriction device is adapted to form a restriction in a pathway corresponding to an amount of fluid contained in the device, and a pressure adjustment unit in communication with the port and effective to maintain a substantially constant equilibrium pressure between the pressure adjustment unit and the restriction device. The pressure adjustment unit is configured to regulate an amount of fluid in the restriction device in response to a fluid pressure acting on the device.

Controlling pressure in adjustable restriction devices

Methods and devices are provided for regulating a hydraulic restriction system. In general, the methods and devices can allow for non-invasive pressure control using a flow control mechanism. The flow control mechanism can be disposed between an implantable restriction device and a fluid source and include an adjustable, variably-sized fluid communication member in fluid communication with the restriction device and the fluid source. The geometry of the fluid communication member can control a rate of fluid flow between the restriction device and the fluid source, thereby also regulating a rate at which a pressure of fluid within the restriction device changes. Alternatively, the fluid flow control mechanism can include a biasing mechanism that can control the rate of fluid flow between the restriction device and the fluid source.

Controlling pressure in adjustable restriction devices

Methods and devices are provided for regulating a hydraulic restriction system including a restriction device. In general, the methods and devices can allow for non-invasive, transient pressure control. The methods and devices can also, in some embodiments, mechanically regulate pressure of the restriction device without using any electrical components that may need to be powered to operate over extended periods of time.

Controlling pressure in adjustable restriction devices

Methods and devices are provided for regulating a hydraulic restriction system. In general, the methods and devices can allow for non-invasive pressure control using a flow control mechanism. The flow control mechanism can be disposed between an implantable restriction device and a fluid source and include an adjustable, variably-sized fluid communication member in fluid communication with the restriction device and the fluid source. The geometry of the fluid communication member can control a rate of fluid flow between the restriction device and the fluid source, thereby also regulating a rate at which a pressure of fluid within the restriction device changes. Alternatively, the fluid flow control mechanism can include a biasing mechanism that can control the rate of fluid flow between the restriction device and the fluid source.

Implantable restriction system with release mechanism

An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A drive element is associated with and engaging the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. A release mechanism is provided for the tension element.

Tissue interface for implantable restriction system

An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. The elongated member has a compressible ventral surface and a substantially rigid dorsal periphery, wherein the elongated member includes a fluid bladder positioned along the ventral surface. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A drive element is associated with and engages the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. Alternate embodiments are also disclosed.

Tissue interface for implantable restriction system

An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. The elongated member has a compressible ventral surface and a substantially rigid dorsal periphery, wherein the elongated member includes a fluid bladder positioned along the ventral surface. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A drive element is associated with and engages the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. Alternate embodiments are also disclosed.

Implantable restriction system with release mechanism

An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element (32) is disposed for movement within the elongated member. A drive element is associated with and engaging the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. A release mechanism (312) is provided for the tension element.

Tissue interface for implantable restriction system

An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. The elongated member has a compressible ventral surface and a substantially rigid dorsal periphery, wherein the elongated member includes a fluid bladder positioned along the ventral surface. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A drive element is associated with and engages the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. Alternate embodiments are also disclosed.

Implantable restriction system with release mechanism

An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A drive element is associated with and engaging the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. A release mechanism is provided for the tension element.

Controlling pressure in adjustable restriction devices

Controlling pressure in adjustable restriction device

Fluid logic for regulating restriction devices

Controlling pressure in adjustable restriction device

Devices are provided for regulating a hydraulic restriction system (120). In general, the devices can allow for non-invasive pressure control using a flow control mechanism (130). The flow control mechanism can be disposed between an implantable restriction device (120) and a fluid source (132) and include an adjustable, variably-sized fluid communication member in fluid communication with the restriction device and the fluid source. The geometry of the fluid communication member can control a rate of fluid flow between the restriction device and the fluid source, thereby also regulating a rate at which a pressure of fluid within the restriction device changes. Alternatively, the fluid flow control mechanism can include a biasing mechanism that can control the rate of fluid flow between the restriction device and the fluid source.

Fluid logic for regulating restriction devices

Methods and devices are provided for regulating a restriction system. In one exemplary embodiment, a restriction system (10) is provided having a restriction device (20) configured to receive fluid and to form a restriction in a pathway corresponding to an amount of fluid contained therein, at least one fluid reservoir (40,50), and a fluid logic system (30) coupled between the restriction device and the at least one fluid reservoir. The fluid logic system is configured to regulate an amount of fluid in the restriction device in response to a fluid pressure acting thereon.

Controlling pressure in adjustable restriction devices

Methods and devices are provided for regulating a hydraulic restriction system (100) including a restriction device (120). In general, the methods and devices can allow for non invasive, transient pressure control. The methods and devices can also, in some embodiments, mechanically regulate pressure of the restriction device without using any electrical components that may need to be powered to operate over extended periods of time.

Controlling pressure in adjustable restriction devices

Methods and devices are provided for regulating a hydraulic restriction system (100) including a restriction device (120). In general, the methods and devices can allow for non invasive, transient pressure control. The methods and devices can also, in some embodiments, mechanically regulate pressure of the restriction device without using any electrical components that may need to be powered to operate over extended periods of time.

Constant force mechanisms for regulating restriction devices

Methods and devices are provided for regulating a restriction system. In one exemplary embodiment, a restriction system is provided having a restriction device coupled to a port with a fluid disposed therein, such that the restriction device is adapted to form a restriction in a pathway corresponding to an amount of fluid contained therein, and a pressure adjustment unit in communication with the port and effective to maintain a substantially constant equilibrium pressure between the pressure adjustment unit and the restriction device. The pressure adjustment unit is configured to regulate an amount of fluid in the restriction device in response to a fluid pressure acting thereon.

Constant force mechanisms for regulating restriction devices

Constant force mechanisms for regulating restriction devices

Devices are provided for regulating a restriction system. In one exemplary embodiment, a restriction system (10) is provided having a restriction device (20) coupled to a port (70) with a fluid disposed therein, such that the restriction device is adapted to form a restriction in a pathway corresponding to an amount of fluid contained therein, and a pressure adjustment unit (30) in communication with the port (70) and effective to maintain a substantially constant equilibrium pressure between the pressure adjustment unit and the restriction device. The pressure adjustment unit is configured to regulate an amount of fluid in the restriction device in response to a fluid pressure acting thereon.

RESTRICTION SYSTEM FOR FORMING A RESTRICTION ON A PATIENT

controle de pressão em dispositivos ajustáveis de restrição. a invenção refere-se a métodos e dispositivos providos para regular um sistema de restrição hidráulico. em geral, os métodos e dispositivos podem permitir um controle de pressão não invasivo que utiliza um mecanismo de controle de fluxo. o mecanismo de controle de fluxo pode estar disposto entre um dispositivo de restrição implantável e uma fonte de fluido e inclui um membro de comunicação de fluido ajustável, de tamanho variável, em comunicação de fluido com o dispositivo de restrição e a fonte de fluido. a geometria do membro de comunicação de fluido pode controlar uma taxa de fluxo de fluido entre o dispositivo de restrição e a fonte de fluido, por meio disto também regulando uma taxa na qual uma pressão de fluido dentro do dispositivo de restrição muda. alternativamente, o mecanismo de controle de fluxo pode incluir um mecanismo de tensionamento que pode controlar a taxa de fluxo de fluido entre o dispositivo de restrição e a fonte de fluido. pressure control in adjustable restraint devices. The invention relates to methods and devices provided for regulating a hydraulic restraint system. In general, methods and devices may allow noninvasive pressure control using a flow control mechanism. The flow control mechanism may be disposed between an implantable restraint device and a fluid source and includes a variable size adjustable fluid communication member in fluid communication with the restraint device and the fluid source. The fluid communication member geometry can control a fluid flow rate between the restriction device and the fluid source, thereby also regulating a rate at which a fluid pressure within the restriction device changes. alternatively, the flow control mechanism may include a tensioning mechanism that can control the flow rate of fluid between the restriction device and the fluid source.

Dressing

Surgical stapling system configured to apply annular rows of staples having different heights

Circular and curved surgical stapling instruments are disclosed comprising circular and curved stapling configurations. A circular staple cartridge comprises a plurality of staples arranged in an inner row, an intermediate row, and an outer row. Staples in certain rows can have different unformed heights. Some arrangements include deck features that protrude from the staple cartridge deck. Various anvil arrangements are also disclosed to attain staples having different formed heights.

Negative pressure device for articulating joint

A negative pressure device includes a drape covering a dressing site on a patient, a sealing element connected with the drape, a flexible gas chamber housing disposed outwardly from the drape with respect to the enclosed chamber, and a reactor. The drape is made from a thin sheet film and is capable of maintaining a negative pressure underneath the drape. The sealing element and the drape are configured so that the sealing element cooperates with the drape to define an enclosed volume covered by the drape and surrounded by the sealing element when applied to skin. The flexible gas chamber housing defines a flexible gas chamber. The reactor is positioned with respect to the enclosed volume and the flexible gas chamber to consume a gas found in air within the enclosed volume and the flexible gas chamber.

Ultrasonic surgical instrument

Hydroxamic acid derivatives as matrix metalloprotease inhibitors

A sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound in an MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity. A contemplated compound corresponds in structure to formula (a) wherein W and the R groups are defined elsewhere.

Thioaryl sulfonamide hydroxamic acid compounds

A thioaryl sulfonamide hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated thioaryl sulfonamide hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.

Elastic stent graft

A stent graft including a stent having a wall having at least one opening, an outer surface, and an inner surface and a covering of a composite material having a least one expanded fluoropolymer membrane and an elastomer is provided. The cover can be used to cover the outer and/or the inner surface of the stent. The expanded fluoropolymer membrane contains serpentine fibrils. In exemplary embodiments, the fluoropolymer is polytetrafluoroethylene. The composite material may be axially and/or circumferentially wrapped around the stent. The composite material is fold-free throughout its operating diameter range and exhibits a sharp increase in stiffness at a predetermined diameter. The stent graft can be designed to have a stop point in either a radial or axial direction. The stent graft can advantageously be implanted undersized with respect to a nominal diameter without having material infolding.

Elastic stent graft

A stent graft including a stent having a wall having at least one opening, an outer surface, and an inner surface and a covering of a composite material having a least one expanded fluoropolymer membrane and an elastomer is provided. The cover can be used to cover the outer and/or the inner surface of the stent. The expanded fluoropolymer membrane contains serpentine fibrils. In exemplary embodiments, the fluoropolymer is polytetrafluoroethylene. The composite material may be axially and/or circumferentially wrapped around the stent. The composite material is fold-free throughout its operating diameter range and exhibits a sharp increase in stiffness at a predetermined diameter. The stent graft can be designed to have a stop point in either a radial or axial direction. The stent graft can advantageously be implanted undersized with respect to a nominal diameter without having material infolding.

Circular surgical stapler

An apparatus includes a body, a shaft, and a stapling head assembly. The body includes a chassis, a bracket, a coupling, and a conical coil. The bracket is configured to move relative to the chassis between first and second positions when selectively activated by a user. The bracket includes an upright member. The conical coil spring is disposed between the bracket and the coupling. The conical coil spring includes a proximal end, a distal end, a conical helical body disposed between the proximal and distal ends, and at least one dead coil disposed at the distal end of the conical coil spring that is configured to prevent the distal end of the conical coil spring from being retained between the bracket and the chassis. The shaft extends distally from the body. The stapling head assembly is positioned at a distal end of the shaft.

Staple height indicator for powered surgical stapler

A surgical instrument includes a body assembly, a distally extending shaft assembly, and a distal stapling assembly configured to clamp, staple, and cut tissue. A first user feedback element is configured to visually inform a user of a first condition of the stapling assembly, and a second user feedback element is configured to visually inform the user of a second condition of the stapling assembly. A circuit board assembly includes a circuit board, a first light source configured to illuminate the first user feedback element, a second light source configured to illuminate the second user feedback element, and a light guide feature. The light guide feature is configured to direct light from the second light source toward the second user feedback element and simultaneously inhibit light emitted by the first light source from illuminating the second user feedback element.

Real-time wideband cylindrical holographic surveillance system

A wideband holographic cylindrical surveillance system including a transceiver for generating a plurality of electromagnetic waves; antenna for transmitting the electromagnetic waves toward a target at a plurality of predetermined positions in space; the transceiver also receiving and converting electromagnetic waves reflected from the target to electrical signals at a plurality of predetermined positions in space; a computer for processing the electrical signals to obtain signals corresponding to a holographic reconstruction of the target; and a display for displaying the processed information to determine nature of the target. The computer has instructions to apply Fast Fourier Transforms and obtain a three dimensional cylindrical image.

Real-time holographic surveillance system

A holographic surveillance system including means for generating electromagnetic waves; means for transmitting the electromagnetic waves toward a target at a plurality of predetermined positions in space; means for receiving and converting electromagnetic waves reflected from the target to electrical signals at a plurality of predetermined positions in space; means for processing the electrical signals to obtain signals corresponding to a holographic reconstruction of the target; and means for displaying the processed information to determine nature of the target. The means for processing the electrical signals includes means for converting analog signals to digital signals followed by a computer means to apply a backward wave algorithm.

Method for the manufacture of susceptor sheet material comprising an aerosol-forming gel and dosing system

The method for the manufacture of a susceptor sheet material comprising an aerosol-forming gel comprises the steps of providing a susceptor sheet material comprising at least one depression on both sides of the susceptor sheet material; and applying aerosol-forming gel to the at least one depression on both sides of the susceptor sheet material. Also a dosing device for the application of an aerosol- forming gel is described.

CRYOGENIC PROCESS FOR THE SELECTIVE REMOVAL OF ACIDIC GAS FROM GAS MIXTURES USING A SOLVENT

PROCEDE CRYOGENIQUE PERMETTANT L'ELIMINATION SELECTIVE DE GAZ ACIDES DE MELANGES DE GAZ AU MOYEN D'UN SOLVANT. CE PROCEDE COMPREND LES ETAPES SUIVANTES: A.INJECTION DU GAZ NATUREL OU DE SYNTHESE DANS UNE PREMIERE COLONNE D'ABSORPTION2 AFIN D'ABSORBER L'ACIDE SULFHYDRIQUE; B.REFROIDISSEMENT DU GAZ PRATIQUEMENT DEBARRASSE D'ACIDE SULFHYDRIQUE POUR CONDENSER UNE PARTIE DU GAZ CARBONIQUE CONTENU DANS LEDIT GAZ; C.INJECTION DU GAZ REFROIDI ET PARTIELLEMENT CONDENSE DANS UNE SECONDE COLONNE D'ABSORPTION7 AFIN DE REDUIRE LA TENEUR EN GAZ CARBONIQUE A LA VALEUR REQUISE; D.REGENERATION DU SOLVANT OU DES SOLVANTS UTILISES DANS L'ABSORPTION DU GAZ ACIDE, LE SOLVANT OU LES SOLVANTS UTILISES ETANT CHOISIS PARMI DES ESTERS, DES ALCOOLS ET DES ETHERS DE BAS POIDS MOLECULAIRE. TRAITEMENT DES GAZ AYANT UNE FORTE TENEUR EN ACIDE SULFHYDRIQUE ET EN GAZ CARBONIQUE. CRYOGENIC PROCESS ALLOWING THE SELECTIVE ELIMINATION OF ACID GAS FROM GAS MIXTURES BY MEANS OF A SOLVENT. THIS PROCESS INCLUDES THE FOLLOWING STEPS: A. INJECTION OF NATURAL OR SYNTHESIS GAS INTO A FIRST ABSORPTION COLUMN2 IN ORDER TO ABSORB SULPHYDRIC ACID; B. COOLING OF THE GAS PRACTICALLY CLEAR OF SULPHYDRIC ACID TO CONDENSATE PART OF THE CARBON GAS CONTAINED IN THE GAS; C. INJECTION OF COOLED AND PARTLY CONDENSED GAS IN A SECOND ABSORPTION COLUMN7 IN ORDER TO REDUCE THE CARBON GAS CONTENT TO THE REQUIRED VALUE; D. REGENERATION OF THE SOLVENT OR SOLVENTS USED IN THE ABSORPTION OF ACID GAS, THE SOLVENT OR SOLVENTS USED BEING CHOSEN FROM ESTERS, ALCOHOLS AND ETHERS OF LOW MOLECULAR WEIGHT. TREATMENT OF GASES WITH A HIGH CONTENT OF SULPHYDRIC ACID AND CARBONIC GAS.

4,5-substituted imidazolyl compounds for the treatment of inflammation

A class of compounds is described for treating inflammation and inflammationrelated disorders. Compounds of particular interest are defined by formula (I), wherein R1 is selected from lower alkyl, lower haloalkyl, lower hydroxyalkyl, lower alkoxyalkyl, lower alkenyloxyalkyl, mercapto, lower alkylcarbonyl, lower haloalkylcarbonyl, phenylcarbonyl, lower aralkylcarbonyl, lower aralkenyl, lower aryloxyalkyl, lower aralkyloxyalkyl, lower arylsulfonyl, lower aralkylsulfonyl, lower arylthioalkyl, lower heteroarylalkylthioalkyl, and heteroaryl selected from 2-thienyl, 2-furyl, 3furyl, 2-pyridyl, 4-pyridyl and 2-benzofuryl; wherein R2 and R3 are independently selected from heteroaryl, cycloalkyl and aryl, wherein the heteroaryl, cycloalkyl and aryl radicals are substituted at a substitutable position with one or more radicals selected from hydrido, halo, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, aminosulfonyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, lower hydroxyalkyl, lower alkoxyalkyl, lower haloalkoxy, amino, lower alkylamino, phenylamino and nitro; and wherein R4 is selected from hydrido, lower alkyl and acyl; or a pharmaceutically acceptable salt thereof.

NEW ORGANIC LIQUIDS BEARING HYDROGEN, THEIR USES FOR THE TRANSPORT AND STORAGE OF HYDROGEN, AND METHODS FOR THE GENERATION OF HYDROGEN USING THEM

La présente invention concerne de nouveaux liquides organiques porteurs d'hydrogène (LOHC), ainsi que les couples LOHC / LOHC déshydrogéné correspondants. L’invention vise également leurs utilisations pour le transport et le stockage d’hydrogène, et les procédés de génération d’hydrogène les utilisant. The present invention relates to new organic hydrogen-carrying liquids (LOHC), as well as the corresponding LOHC/dehydrogenated LOHC couples. The invention also relates to their uses for the transport and storage of hydrogen, and the hydrogen generation processes using them.

Chemical pump housing for negative pressure system

A chemical pump assembly useful for negative pressure therapy includes a chemical pump housing having an inner chamber, a reactor located within the inner chamber, an opening provided in the chemical pump housing, a first pull tab which extends from the inner chamber to ambient through the opening, and a removable layer connected to the first pull tab. The reactor is configured to react with a selected gas found in air so as to consume the selected gas when exposed to air in the inner chamber. The removable layer shields the reactor from air in the inner chamber atmosphere until the removable layer is removed.

ARTICULATED RECREATIONAL DEVICE EQUIPPED WITH A HOOK FOR ATTACHING RINGS

L'INVENTION CONCERNE UN DISPOSITIF RECREATIF ARTICULE, EQUIPE D'UN CROCHET POUR ATTRAPER DES ANNEAUX. CE DISPOSITIF, EN FORME DE DRAGON, COMPREND UN CORPS 24 DELIMITANT UNE CUVETTE OUVERTE 26; UN COU FLEXIBLE ALLONGE 14 SAILLANT NORMALEMENT AU-DELA DU CORPS 24; ET UNE TETE 16 FIXEE AU COU 14 ET PRESENTANT UNE LANGUE FOURCHUE SAILLANTE 18. UNE QUEUE OU POIGNEE 74 A L'ARRIERE DU CORPS 24 SERT A COURBER LE COU 14 VERS LE HAUT ET VERS L'ARRIERE POUR DEPLACER LA TETE 16 A L'INTERIEUR OU AU-DESSUS DE LA CUVETTE 26. DES ELEMENTS ANNULAIRES D'AMUSEMENT 78 PEUVENT ETRE DEPOSES PAR LA LANGUE 18 DANS LA CUVETTE 26 EN MANIPULANT LA POIGNEE 74. APPLICATION AUX JEUX RECREATIFS DE SOCIETE. THE INVENTION CONCERNS AN ARTICULATED RECREATIONAL DEVICE, EQUIPPED WITH A HOOK FOR CATCHING RINGS. THIS DEVICE, IN THE SHAPE OF A DRAGON, INCLUDES A BODY 24 DELIMING AN OPEN BOWL 26; AN EXTENDED FLEXIBLE NECK 14 PROJECTING NORMALLY BEYOND THE BODY 24; AND A HEAD 16 ATTACHED TO THE NECK 14 AND SHOWING A PROJECTING FORKED TONGUE 18. A TAIL OR HANDLE 74 AT THE REAR OF THE BODY 24 IS USED TO BEND THE NECK 14 UP AND BACK TO MOVE THE HEAD 16 TO THE INSIDE OR ABOVE THE BOWL 26. ANNULAR FUN ELEMENTS 78 CAN BE DEPOSITED BY LANGUAGE 18 IN THE BOWL 26 BY MANIPULATING THE HANDLE 74. APPLICATION TO RECREATIONAL GAMES.

Aerosol-generating article including upstream element

There is provided an aerosol-generating article (10) for producing an inhalable aerosol upon heating, the aerosol-generating article (10) comprising: a rod (12) of aerosol-generating substrate comprising a gel composition, the gel composition comprising at least one gelling agent, at least one of an alkaloid compound and a cannabinoid compound and an aerosol former; an upstream element (46) upstream of the rod (12) of aerosol-generating substrate and abutting the upstream end of the rod (12) of aerosol-generating substrate; and a downstream section (14) arranged downstream of the rod (12) of aerosol-generating substrate and in axial alignment with the rod (12) of aerosol-generating substrate, the downstream section (14) comprising one or more downstream elements. The resistance to draw (RTD) of the upstream element is between 5 millimetres H2O and 80 millimetres H2O.

USE OF HUMAN CB2 RECEPTOR AGONIST COMPOUNDS FOR THE PREPARATION OF IMMUNOMODULATORY DRUGS, NOVEL CB2 RECEPTOR AGONIST COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Technologies for flexible protocol acceleration

Technologies for flexible I/O protocol acceleration include a computing device having a root complex, a smart endpoint coupled to the root complex, and an offload complex coupled to the smart endpoint. The smart endpoint receives an I/O transaction that originates from the root complex and parses the I/O transaction based on an I/O protocol and identifies an I/O command. The smart endpoint may parse the I/O transaction based on endpoint firmware that may be programmed by the computing device. The smart endpoint accelerates the I/O command and provides a smart context to the offload complex. The smart endpoint may copy the I/O command to memory of the smart endpoint or the offload complex. The smart endpoint may identify protocol data based on the I/O command and copy the protocol data to the memory of the smart endpoint or the offload complex. Other embodiments are described and claimed.

Aromatic sulfone hydroxamic acid metalloprotease inhibitor

A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-9 and MMP-13, while exhibiting substantially less inhibition at least of MMP-1 to a host having a condition associated with pathological matrix metalloprotease activity. Also disclosed are metalloprotease inhibitor compounds having those selective activities, processes for manufacture of such compounds and pharmaceutical compositions using an inhibitor.

Aerosol-generating article including upstream element

There is provided an aerosol-generating article (10) for producing an inhalable aerosol upon heating, the aerosol-generating article (10) comprising: a rod (12) of aerosol-generating substrate comprising a gel composition, the gel composition comprising at least one gelling agent, at least one of an alkaloid compound and a cannabinoid compound and an aerosol former; an upstream element (46) upstream of the rod (12) of aerosol-generating substrate and abutting the upstream end of the rod (12) of aerosol-generating substrate; and a downstream section (14) arranged downstream of the rod (12) of aerosol-generating substrate and in axial alignment with the rod (12) of aerosol-generating substrate, the downstream section (14) comprising one or more downstream elements. The resistance to draw (RTD) of the upstream element is between 5 millimetres H 2 O and 80 millimetres H 2 O.

3-Arylcarbonyl-1H-indoles useful as therapeutic agents

2-R₂-R₄-substituted-3-R₃-CO-1-[(C-attached-N-heteryl)-(Alk) n ]-1H-indoles useful as analgesic, anti-rheumatic, anti-inflammatory or anti-glaucoma agents.

Electronic time lock

An electronic time lock for bank vault doors and the like having a door bolting mechanism including a snubber bar, the time lock including a lock case, an intermediate vertical partition located in said chamber between front and rear walls of the case, the rear wall and intermediate partition having surfaces defining cylindrical guide bores for reciprocating movement of the snubber bar therein. A pair of electric motors are arranged in side-by-side relation on the intermediate partition to drive a blocking member through a pair of drive trains between blocking and release position for blocking the snubber bar against movement to an unlocking position and releasing the snubber bar. A printed circuit board is provided having a solid state visible display strip for displaying programmed instructions and information regarding the state of the time lock aligned with a window in the front wall of the case for viewing of the displayed information therethrough and a plurality of electrical switch program buttons are located on the front wall of the lock case.

Lubricant refrigerant composition for hydrofluorocarbon (hfc) refrigerants

A lubricant-refrigerant composition contained within a compression refrigeration system is disclosed which comprises: (A) at least one fluorine-containing hydrocarbon refrigerant containing 1 to 3 carbon atoms, further wherein fluorine is the only halogen in said fluorine-containing hydrocarbon with the proviso that 1,1,1,2-tetrafluoroethane is not the sole refrigerant; and (B) at least one lubricant comprising: (1) a hydrocarbyl substituted arene, (2) a phosphate ester, (3) an organic ester of a carboxylic acid and an alcohol, (4) a perfluoropolyethylene, (5) an ether, (6) a polyether, (7) a polyalphaolefin, or (8) a mineral oil, wherein at a temperature of above -60 °C, a phase separation occurs such that at least two phases are formed, said phases being a refrigerant rich phase and a lubricant rich phase, further wherein the lubricant rich phase resides below the refrigerant rich phase.

Negative pressure device and method

A negative pressure device includes a drape, a wicking element, a sealing element, a reactor, a chamber and an air permeable liquid impervious element. The drape includes an opening and is made from a flexible material that inhibits passage of liquid and air through the drape other than through the opening. The wicking element is covered by the drape. The sealing element surrounds the wicking element and cooperates with the drape to define an enclosed volume covered by the drape and surrounded by the sealing element. Air within the enclosed volume is inhibited from exiting the enclosed volume other than through the opening. The reactor is configured to react with a gas found in air to consume the gas. The chamber is in fluid communication with the reactor and the enclosed volume via the opening. The chamber is configured to maintain a predefined chamber volume while the gas is being consumed from the enclosed volume. The air permeable liquid impervious element is interposed between the chamber and the enclosed volume and is configured to preclude liquid from entering the chamber.

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Electronic time lock

ABSTRACT OF THE DISCLOSURE An electronic time lock for bank vault doors and that a having a door bolting mechanism including a snubber bar, the time lock including a lock case, an intermediate vertical partition located in said chamber between front and rear walls of the case, the rear wall and intermediate partition having surfaces defining cylindrical guide bores for reciprocating movement of the snubber bar therein. A pair of electric motors are arranged in side-by-side relation on the intermediate partition to drive a blocking member through a pair of drive trains between blocking and release position for blocking the snubber bar against movement to an unlocking position and releasing the snubber bar. A printed circuit board is provided having a solid state visible display strip for displaying programmed instructions and information regarding the state of the time lock aligned with a window in the front wall of the case for viewing of the displayed information therethrough and a plurality of electrical switch program buttons are located on the front wall of the lock case.

Vehicle mounting platform using existing opening

A mounting platform attached to a vehicle through an existing opening. A base portion having a clamp is placed through a brake light assembly opening, after the brake light assembly has been removed, and is securely held to the roof of a vehicle. A platform portion is attached to the base portion. The mounting platform is used to mount accessories such as light bars, emergency lights, antennas, or any other accessory desired to be mounted to the vehicle. The mounting platform may be easily installed and removed from the vehicle without any damage or modification to the vehicle and without drilling any additional holes in the vehicle.

Process for production of piperidine derivatives

The present invention relates to a process for preparing piperidine derivative compounds of the formulae: wherein n is 0 or 1; R 1 is hydrogen or hydroxy; R 2 is hydrogen; or, when n is 0 , R 1 and R 2 taken together form a second bond between the carbon atoms bearing R 1 and R 2 , provided that when n is 1 , R 1 and R 2 are each hydrogen; R 3 is —COOH or —COOR 4 ; R 4 is an alkyl or aryl moiety; A, B, and D are the substituents of their rings, each of which may be different or the same, and are selected from the group consisting of hydrogen, halogens, alkyl, hydroxy, alkoxy, and other substituents, The process comprises providing a regiosomer of the following formula: wherein Z is —CG 1 G 2 G 3 , m is an integer from 1 to 6; Q and Y are the same or different and are selected from the group consisting of O, S, and NR 5 ; G 1 , G 2 , and G 3 are the same or different and are selected from the group consisting of OR 8 , SR 8 , and NR 8 R 9 ; R 6 and R 7 are the same or different and are selected from the group consisting of hydrogen, an alkyl moiety, an aryl moiety, OR 8 , SR 8 , and NR 8 R 9 ; and R 5 , R 8 , and R 9 are the same or different and are selected from the group consisting of hydrogen, an alkyl moiety, and an aryl moiety and converting the regioisomer to the piperidine derivative compound with a piperidine compound.

Mechanism for assembly of ultrasonic instrument

An ultrasonic clamp coagulator system that is configured to permit selective cutting, coagulation and clamping of tissue during surgical procedures. An elongated portion of the instrument can be configured for endoscopic applications and has an outside diameter of less than 6 mm. The system includes a one-piece torque wrench that is provided with cantilever arms aligned in an annular fashion about the centerline of the torque wrench. The cantilever arms include teeth in an inward perpendicular fashion in relation to cantilever arms. The clamp coagulator includes an outer tube retainer that includes spline gears projecting in a perpendicular fashion along the outer circumference of retainer. Torque is transmitted through the cantilever arms to the spline gears for attaching a handpiece to the clamp coagulator.

Outsole for a shoe

Imaging systems and related methods including radar imaging with moving arrays or moving targets

Imaging systems, including radio frequency, microwave and millimeter-wave arrangements, and related methods are described. According to one aspect, an imaging system includes an antenna array, a position capture system configured to generate position information indicative of locations of one of the antenna array and the target at the first and second moments in time, and wherein the one of the antenna array and the target move between the first and second moments in time, a transceiver configured to control the antenna array to emit electromagnetic energy towards the target and to generate an output that is indicative of the received electromagnetic energy, a data acquisition system configured to generate radar data, processing circuitry configured to process the position information and the radar data to generate image data regarding the target, and an interface configured to use the image data to generate visual images regarding the target.

Boiler construction

Lubricant refrigerant composition for hydrofluorocarbon (HFC) refrigerants

Detection of a concealed object

Disclosed are systems, methods, devices, and apparatus to determine if a clothed individual is carrying a suspicious, concealed object. This determination includes establishing data corresponding to an image of the individual through interrogation with electromagnetic radiation in the 200 MHz to 1 THz range. In one form, image data corresponding to intensity of reflected radiation and differential depth of the reflecting surface is received and processed to detect the suspicious, concealed object.

Aromatic sulfone hydroxamic acid metalloprotease inhibitor

A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-9 and MMP-13, while exhibiting substantially less inhibition at least of MMP-1 to a host having a condition associated with pathological matrix metalloprotease activity. The administered enzyme inhibitor corresponds in structure to formula (I), below, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are both hydrido or R1 and R2 together with atoms to which they are bonded form a 5- to 8-membered ring containing one, two or three heteroatoms in the ring that are oxygen, sulfur or nitrogen. R3 in formula (I) is an optionaly substituted aryl or optionally substituted heteroaryl radical. Also disclosed are metalloprotease inhibitor compounds having those selective activities, processes for manufacture of such compounds and pharmaceutical compositions using an inhibitor.

Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors

This invention is directed generally to proteinase (also known as "protease") inhibitors, and more particularly, to piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids that inter alia, inhibit matrix metalloproteinase (also known as "matrix metalloprotease" or "MMP") activity and/or aggrecanase activity. Such hydroxamic acids generally correspond in structure to formula (I), (Wherein A1, A2, Y, E1, E2, E3, and Rx are as defined in this specification), and further include salts of such compounds. This invention also is directed to compositions of such hydroxamic acids, intermediates for the syntheses of such hydroxamic acids, methods for making such hydroxamic acids, and methods for treating conditions (particularly pathological conditions) associated with MMP activity and/or aggrecanase activity.

Process for production of piperidine derivatives

Novel amino azaheterocyclic carboxamides

Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists.

The present invention is directed to compounds of formula (1)and pharmaceutically acceptable salts and isomers thereof use ful as ... integrin antagonists.

Negative pressure device for articulating joint

A negative pressure device includes a drape covering a dressing site on a patient, a sealing element connected with the drape, a flexible gas chamber housing disposed outwardly from the drape with respect to the enclosed chamber, and a reactor. The drape is made from a thin sheet film and is capable of maintaining a negative pressure underneath the drape. The sealing element and the drape are configured so that the sealing element cooperates with the drape to define an enclosed volume covered by the drape and surrounded by the sealing element when applied to skin. The flexible gas chamber housing defines a flexible gas chamber. The reactor is positioned with respect to the enclosed volume and the flexible gas chamber to consume a gas found in air within the enclosed volume and the flexible gas chamber.

Imidazole derivatives, their preparation and pharmaceutical compositions containing them

N-hydroxy 4-sulfonyl butanamide compounds

Longitudinal bulging seal for spray gun

The seal (10) for a spray gun (20) is tubular in form and molded from an elastomer. The seal is placed in compression between two generally parallel surfaces (12) so as to seal out the fluid (such as paint) from the rod (14). As the trigger (16) is pulled and the rod (14) moved rearward, the seal (10) bulges to accomodate the travel without exposing the rod (14) to the fluid.

Cb 2? receptor agonist compounds

The use of human CB2 receptor-specific agonists of formula (I) or (I') for preparing immunomodulating drugs is disclosed. In formulae (I) and (I'), R1 is a group selected from -CH2CHR10NR6R11, -(CH2)2NR'6R'11, -CHR9CH2NR'6R'11, -(CH2)nZ and -COR8; R'1 is a -CH2CHR10NR6R11 or -(CH2)2NR'6R'11 group; R2 and R'2 are hydrogen, halogen or C1-4 alkyl; R3 is hydrogen, C1-4 alkyl or a group selected from -CH2CHR10NR6R11, -(CH2)2NR'6R'11 and -COR8; R'3 is a =CR6R8 group; R4 has one of the meanings given for R5 or is a -COR8 group; R5 is hydrogen, C1-4 alkyl, C1-4 alkoxy, a halogen atom, a CF3 group, an OCF3 group or C1-4 alkylthio; R'5 has one of the meanings given for R5 and is in the 5 or 6 position of the indene ring; R6 is hydrogen or C1-4 alkyl; R'6 is C1-4 alkyl; R7 has one of the meanings given for R5 or R7 and R9 together form a -Y-CH2- group attached to the indole ring in the 7 position by a group Y; R8 is phenyl substituted one to four times by a substituent selected from halogen, C1-4 alkyl or C1-4 alkoxy; a polycyclic ring selected from naphth-1-yl, naphth-2-yl, 1,2,3,4-tetrahydronaphth-1-yl, 1,2,3,4-tetrahydronaphth-5-yl, anthryl, benzofuryl, benzothien-2-yl, benzothien-3-yl, 2-, 3-, 4- or 8-quinolyl, said polycyclic rings optionally being substituted once or twice by a substituent selected from C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, halogen, cyano, hydroxyl, trifluoromethyl and imidazol-1-yl; R10 and R11 together are a group selected from -CH2-O-CH2-CR12R13- and -(CH2)p-CR12R13-, wherein the carbon atom substituted by R12 and R13 is attached to the nitrogen atom; R'11 is C1-4 alkyl; or R'11 and R'6, taken together with the nitrogen atom to which they are attached, form a group selected from morpholin-4-yl, thiomorpholin-4-yl, piperidin-1-yl and pyrolidin-1-yl; each of R12 and R13 is independently hydrogen or C1-4 alkyl; n is 2, 3, 4 or 5; p is 2 or 3; Z is a methyl group or a halogen atom; ...

Method for making susceptor sheet material comprising an aerosol forming gel and dosing system

método para a fabricação de material de folha de susceptor que compreende um gel formador de aerossol e sistema de dosagem. o método para a fabricação de um material de folha de susceptor que compreende um gel formador de aerossol compreende as etapas de fornecer um material de folha de susceptor que compreende pelo menos uma depressão em ambos os lados do material de folha de susceptor; e aplicar gel formador de aerossol a pelo menos uma depressão em ambos os lados do material de folha de susceptor. também é descrito um dispositivo dosador para a aplicação de um gel formador de aerossol. method for making susceptor sheet material comprising an aerosol forming gel and dosing system. the method for manufacturing a susceptor sheet material comprising an aerosol forming gel comprises the steps of providing a susceptor sheet material comprising at least one depression on either side of the susceptor sheet material; and applying aerosol forming gel to at least one depression on either side of the susceptor sheet material. a metering device for delivering an aerosol forming gel is also described.

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Method and apparatus for sharing TLB entries

A sharing mechanism is herein disclosed for multiple logical processors using a translation lookaside buffer (TLB) to translate virtual addresses, for example into physical addresses. The mechanism supports sharing of TLB entries among logical processors, which may access address spaces in common. The mechanism further supports private TLB entries among logical processors, which for example, may each access a different physical address through identical virtual addresses. The sharing mechanism provides for installation and updating of TLB entries as private entries or as shared entries transparently, without requiring special operating system support or modifications. Through use of the disclosed sharing mechanism, fast and efficient virtual address translation is provided without requiring more expensive functional redundancy.

Negative pressure device and method

A negative pressure device includes a drape, a wicking element, a sealing element, a reactor, a chamber and an air permeable liquid impervious element. The drape includes an opening and is made from a flexible material that inhibits passage of liquid and air through the drape other than through the opening. The wicking element is covered by the drape. The sealing element surrounds the wicking element and cooperates with the drape to define an enclosed volume covered by the drape and surrounded by the sealing element. Air within the enclosed volume is inhibited from exiting the enclosed volume other than through the opening. The reactor is configured to react with a gas found in air to consume the gas. The chamber is in fluid communication with the reactor and the enclosed volume via the opening. The chamber is configured to maintain a predefined chamber volume while the gas is being consumed from the enclosed volume. The air permeable liquid impervious element is interposed between the chamber and the enclosed volume and is configured to preclude liquid from entering the chamber.

Hollow structure and method of making the same

New NPY antagonists

High throughput chemical mechanical polishing system

Embodiments of a system and method for polishing substrates are provided. In one embodiment, a polishing system is provided that includes a polishing module, a cleaner and a robot. The robot has a range of motion sufficient to transfer substrates between the polishing module and cleaner. The polishing module includes at least two polishing stations, at least one load cup and at least four polishing heads. The polishing heads are configured to move independently between the at least two polishing stations and the at least one load cup.

Dual chamber megasonic cleaner

Embodiments described herein relate to semiconductor device manufacturing, and more particularly to a vertically oriented dual megasonic module for simultaneously cleaning multiple substrates. In one embodiment, an apparatus for cleaning multiple substrates is provided. The apparatus comprises an outer tank for collecting overflow processing fluid comprising at least one sidewall and a bottom. A first inner module adapted to contain a processing fluid is positioned partially within the outer tank. The first inner module comprises one or more roller assemblies to hold a substrate in a substantially vertical orientation. A second inner module adapted to contain a processing fluid is positioned partially within the outer tank. The second inner module comprises one or more roller assemblies adapted to hold a substrate in a substantially vertical orientation. Each inner module contains a transducer adapted to direct vibrational energy through the processing fluid toward the substrates.

System for creating workflow maps of business processes

The invention is a system which provides consultants, business process analysts, and application developers (Fig. 3) with a unified tool (Fig. 4) with which to conduct business process analysis, design, and documentation. The invention may be implemented using a software system which has two functional sets. One is a set of graphical tools that can be used by a developer or a business analyst to map out business processes (Fig. 3). The second is a set of tools that can be used to document and specify in detail the attributes of each workflow definition (Fig. 3), including roles, timing, conditions of satisfaction (Figs. 1a-1e), forms, and links (Fig. 2) required to complete a business process definition. The invention utilizes the fundamental concept of workflow analysis that any business process can be interpreted as a sequence of basic transactions called workflows (Fig. 2).

Outsole for a shoe

Imaging systems and related methods including radar imaging with moving arrays or moving targets

Imaging systems, including radio frequency, microwave and millimeter-wave arrangements, and related methods are described. According to one aspect, an imaging system includes an antenna array, a position capture system configured to generate position information indicative of locations of one of the antenna array and the target at the first and second moments in time, and wherein the one of the antenna array and the target move between the first and second moments in time, a transceiver configured to control the antenna array to emit electromagnetic energy towards the target and to generate an output that is indicative of the received electromagnetic energy, a data acquisition system configured to generate radar data, processing circuitry configured to process the position information and the radar data to generate image data regarding the target, and an interface configured to use the image data to generate visual images regarding the target.