Conformational Epitope Initiated Signal Amplification

This invention relates to a method to generate a signal used to detect the presence or quantity of a biomarker in a sample. The signal generating reaction is initiated when the biomarker under assay interacts with a specific binding partner. The interaction produces a structural change in the binding partner that is recognized by additional binding partners capable of generating a signal. The reaction produces a localized cluster of signaling molecules that can be detected above background. The signaling cluster is detectable within minutes when interrogated in a chamber of specific dimensions. The presence of the signaling clusters is a qualitative indication of the presence of the analyte, while the number of signaling clusters detected is a direct quantification of the number of biomarker molecules in the sample. The reaction can be formatted to detect proteins, nucleic acids, cells or other informative biomarkers.

Adjustable Clamshell Assembly Fixture

A system for forming different types of clamshell components including a moveable base, a stationary base, and a squeezer assembly capable of accommodating different types of clamshell components having different lengths, shapes, locations of piercings. The squeezer assembly includes interchangeable squeezer elements. To switch between forming a first type of clamshell component and a second type of clamshell component, one of the two bases is moved relative to the other of the two bases and/or squeezer units for forming the first type of clamshell component are replaced with squeezer units for forming the second type of clamshell component. Reconfiguring the bases and interchanging the squeezers of a clamshell tool, instead of replacing an entire clamshell tool with a different clamshell tool, minimizes lost productivity time, reduces capital costs, and eliminates the problem of storing several different clamshell assembly tools.

Collapsible Fire Pit and Propane Tank Holder

A fire pit designed to be stored and shipped in a flat configuration, and assembled without tools in a matter of minutes into a freestanding, durable structure capable of functioning as well or better than a non-collapsible fire pit. The fire pit comprises an essentially flat base with a unique slot and flange structure adapted to receive and support side panels. The side panels include female sides with vertical corner members on their side edges that allow flat male sides to mate securely with the female sides, and with the intersecting edges of the sides both covered and reinforced for a neat appearance and robust structure. A top includes a slot and flange structure that fits over and unifies and hides the upper edges of the sides, completing the assembly.

Oleophilic Lubricated Catheters

A medical device wherein the device has an outer surface coated with an oleophilic lubricous coating or the device is formed from a mixture including a polymer and an oleophilic compound.

Method of preparing silicon carbide and filters made therefrom

A method of making SiC nanowires comprising: (a) mixing silicon powder with a carbon-containing biopolymer and a catalyst at room temperature to form a mixture; and (b) heating said mixture to a pyrolyzing temperature sufficient to react said biopolymer and said silicon power to form SiC nanowires.

Rear access article of footwear with movable heel portion

An article of footwear comprises a sole structure, and an upper including a front section and a rear section. The front section is fixed to a forefoot region of the sole structure and partially defines a foot-receiving cavity. The rear section is operatively secured to the sole structure at least partially rearward of the front section, and includes medial and lateral wings. A medial set of magnets includes at least one front medial magnet secured to a medial side of the front section and at least one rear medial magnet secured to the medial wing. A lateral set of magnets includes at least one front lateral magnet secured to a lateral side of the front section and at least one rear lateral magnet secured to the lateral wing. The rear section is movable relative to the front section between an access position and a use position.

FOOTWEAR HEEL SPRING DEVICE

A device configured to surround a portion of a foot-receiving cavity at a heel region of an article of footwear comprises a control bar having a center segment, a first side arm extending from the center segment, and a second side arm spaced from the first side arm and extending from the center segment. The control bar may include a series of slats. A base supports the control bar and is connected to the first side arm and the second side arm. The control bar is biased to an unstressed position with the center segment a first distance from the base, and elastically bends under an applied force to a loaded position with the center segment a second distance from the base less than the first distance. The device stores potential energy that returns the control bar to the unloaded position upon removal of the applied load. 1. A device for easing foot entry into an article of footwear , the device comprising:a body having a fold and configured to surround a portion of a foot-receiving cavity at a heel region of the article of footwear with the fold at a rear of the heel region and extending in a direction around the rear of the heel region from a medial side to a lateral side of the article of footwear;wherein the body is biased to an unloaded position and compresses at the fold under an applied force to a loaded position, storing elastic energy that returns the body to the unloaded position upon removal of the applied force.2. The device of claim 1 , wherein the body includes a center portion claim 1 , a medial side portion extending forwardly from the center portion claim 1 , and a lateral side portion extending forwardly from the center portion.3. The device of claim 2 , wherein the medial side portion and the lateral side portion taper in height in a direction away from the center portion.4. The device of claim 2 , wherein the body includes alternating ridges and grooves that extend lengthwise along the center portion from the medial side portion to the lateral side ...

FOOTWEAR HEEL SPRING DEVICE

A device configured to surround a portion of a foot-receiving cavity at a heel region of an article of footwear comprises a control bar having a center segment, a first side arm extending from the center segment, and a second side arm spaced from the first side arm and extending from the center segment. The control bar may include a series of slats. A base supports the control bar and is connected to the first side arm and the second side arm. The control bar is biased to an unstressed position with the center segment a first distance from the base, and elastically bends under an applied force to a loaded position with the center segment a second distance from the base less than the first distance. The device stores potential energy that returns the control bar to the unloaded position upon removal of the applied load. 1. A device for easing foot entry into an article of footwear , the device comprising:{'claim-text': ['a center segment;', 'a medial side arm extending from the center segment to a medial end; and', 'a lateral side arm extending from the center segment to a lateral end;'], '#text': 'a control bar that includes a series of slats, each slat having:'}wherein the medial side arm and the lateral side arm of each slat bends and the center segment of each slat pivots downward and rearward relative to the medial end of the medial side arm and the lateral end of the lateral side arm under an applied force to a loaded position, storing potential energy that returns the center segment of each slat to an unloaded position upon removal of the applied force.2. The device of claim 1 , wherein:the control bar defines slots extending between the slats;the slats are spaced apart from one another by the slots when the control bar is in the unloaded position; andone or more of the slots close between the slats so that adjacent center segments contact one another in the loaded position.3. The device of claim 2 , wherein the adjacent center segments are configured to slide ...

Urinary Catheters Having Limited Reusability

A reusable urinary catheter assembly includes a catheter shaft and a plurality of removable members associated with the catheter shaft. A different one of the removable members is configured to be removed from the catheter shaft between each consecutive use of the reusable urinary catheter assembly. By such a configuration, the number of times that the reusable urinary catheter may be reused is limited by the number of removable members.

FOOTWEAR UPPER WITH LACE-ENGAGED ZIPPER SYSTEM

A footwear upper comprises a front section and a rear section. The front section is at least partially forward of the rear section and at least partially defines a foot-receiving cavity. The front section has a medial edge and a lateral edge partially defining a foot entry opening. A zipper system includes a medial slider movable along the medial edge of the front section to zip the rear section to the medial edge, a medial zipper pull engaged with the medial slider, a lateral slider movable along the lateral edge of the front section to zip the rear section to the lateral edge, and a lateral zipper pull engaged with the lateral slider. A tightening system includes a lace-receiving feature on the front section forward of the zipper system, and a lace extending through the lace-receiving feature, through the medial zipper pull, and through the lateral zipper pull. 1. A footwear upper comprising:a front section at least partially defining a foot-receiving cavity and a foot entry opening in communication with the foot-receiving cavity;a rear section having a central portion fixed to the front section, the rear section articulatable relative to the front section at the central portion between an access position and a use position;a medial zipper disposed along a medial edge of the front section at the foot entry opening; anda lateral zipper disposed along a lateral edge of the front section at the foot entry opening with the central portion of the rear section between the medial zipper and the lateral zipper.2. The footwear upper of claim 1 , wherein the rear section is disposed rearward of the foot entry opening in the access position when the medial zipper and the lateral zipper are unzipped claim 1 , and articulates at the central portion to be disposed around the foot entry opening in the use position when the medial zipper and the lateral zipper are zipped.3. The footwear upper of claim 1 , wherein the medial zipper includes a medial slider movable along the medial ...

UPPER COMPONENT FOR AN ARTICLE OF FOOTWEAR

An upper component for an article of footwear allows easy entry of the foot into the article of footwear. The upper component includes a heel body, which includes a first portion partially defining an ankle opening. The heel body further includes a second portion coupled to the first portion. The second portion is foldable and partially defines the ankle opening. The second portion is movable relative to the first portion between an unfolded configuration and a folded configuration. The upper component includes at least one tension member coupled to the second portion. The tension member is movable relative to the first portion to move the second portion from the unfolded configuration to the folded configuration. The ankle opening is larger when the second portion is in the unfolded configuration than when the second portion is in the folded configuration.

Heterobifunctional pan-selectin inhibitors

Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).

UPPER COMPONENT FOR AN ARTICLE OF FOOTWEAR

An upper component for an article of footwear allows easy entry of the foot into the article of footwear. The upper component includes a heel body, which includes a first portion partially defining an ankle opening. The heel body further includes a second portion coupled to the first portion. The second portion is foldable and partially defines the ankle opening. The second portion is movable relative to the first portion between an unfolded configuration and a folded configuration. The upper component includes at least one tension member coupled to the second portion. The tension member is movable relative to the first portion to move the second portion from the unfolded configuration to the folded configuration. The ankle opening is larger when the second portion is in the unfolded configuration than when the second portion is in the folded configuration. 1. An upper component for an article of footwear , comprising: a first portion partially defining an ankle opening;', 'a second portion coupled to the first portion, wherein the second portion is foldable and partially defines the ankle opening, and the second portion is movable relative to the first portion between an unfolded configuration and a folded configuration;, 'a heel body includingat least one tension member coupled to the second portion, wherein the at least one tension member is movable relative to the first portion to move the second portion from the unfolded configuration to the folded configuration; andwherein the ankle opening is larger when the second portion is in the unfolded configuration than when the second portion is in the folded configuration.2. The upper component of claim 1 , further comprising a tube partly disposed inside the first portion claim 1 , wherein:the at least one tension member is disposed in the tube to minimize friction between the at least one tension member and the heel body when the tension member moves relative to the first portion.3. The upper component of claim 1 , ...

FOOTWEAR HEEL SPRING DEVICE

A device configured to surround a portion of a foot-receiving cavity at a heel region of an article of footwear comprises a control bar having a center segment, a first side arm extending from the center segment, and a second side arm spaced from the first side arm and extending from the center segment. The control bar may include a series of slats. A base supports the control bar and is connected to the first side arm and the second side arm. The control bar is biased to an unstressed position with the center segment a first distance from the base, and elastically bends under an applied force to a loaded position with the center segment a second distance from the base less than the first distance. The device stores potential energy that returns the control bar to the unloaded position upon removal of the applied load. 1. A device configured to surround a portion of a foot-receiving cavity at a heel region of an article of footwear , the device comprising:a control bar having a center segment, a first side arm extending from the center segment, and a second side arm spaced from the first side arm and extending from the center segment;a continuous base supporting the control bar and connected to both of the first side arm and the second side arm; andwherein the control bar is biased to an unstressed position with the center segment a first distance from the base, the control bar elastically deforms under an applied force to a loaded position with the center segment a second distance from the base less than the first distance, and the device stores potential energy that returns the control bar to the unstressed position upon removal of the applied load.2. The device of claim 1 , wherein the base is connected to the first side arm at a first joint claim 1 , and the base is connected to the second side arm at a second joint.3. The device of claim 2 , wherein:the control bar has an arced shape from the first joint to the second joint;the base has an arced shape from the ...

Footwear heel spring device

A device configured to surround a portion of a foot-receiving cavity at a heel region of an article of footwear comprises a control bar having a center segment, a first side arm extending from the center segment, and a second side arm spaced from the first side arm and extending from the center segment. The control bar may include a series of slats. A base supports the control bar and is connected to the first side arm and the second side arm. The control bar is biased to an unstressed position with the center segment a first distance from the base, and elastically bends under an applied force to a loaded position with the center segment a second distance from the base less than the first distance. The device stores potential energy that returns the control bar to the unloaded position upon removal of the applied load.

Devices, systems, and methods for securing tissue

The present disclosure pertains to medical devices. More particularly, the present disclosure pertains to devices, systems, and methods for securing tissue, such as a tissue defect or wound resulting from an endoscopic procedure, e.g., an endoscopic mucosal resection or submucosal dissection procedure. In one example, a device for securing tissue may include a loop portion configured to be disposed about a distal end of a delivery device in a delivery configuration and configured to be secured about the tissue in a deployed configuration. A locking member may be disposed on the loop portion. A tether portion having a proximal end extendable proximally within the delivery device and a distal portion extending from the loop portion slidably through the locking member.

FOOTWEAR HEEL SPRING DEVICE

A device configured to surround a portion of a foot-receiving cavity at a heel region of an article of footwear comprises a control bar having a center segment, a first side arm extending from the center segment, and a second side arm spaced from the first side arm and extending from the center segment. The control bar may include a series of slats. A base supports the control bar and is connected to the first side arm and the second side arm. The control bar is biased to an unstressed position with the center segment a first distance from the base, and elastically bends under an applied force to a loaded position with the center segment a second distance from the base less than the first distance. The device stores potential energy that returns the control bar to the unloaded position upon removal of the applied load. 1. A device for easing foot entry into an article of footwear , the device comprising:a control bar and a base underlying the control bar; a center segment;', 'a medial side arm extending from the center segment to a medial end connected to a medial side of the base; and', 'a lateral side arm extending from the center segment to a lateral end connected to a lateral side of the base;, 'wherein the control bar includes a series of slats, each slat havingwherein the control bar is biased to an unloaded position and elastically bends under an applied force to a loaded position in which at least one center segment is closer to the base than in the unloaded position, storing potential energy that returns the control bar to the unloaded position upon removal of the applied force.2. The device of claim 1 , wherein the control bar and the base are configured as a full elliptical leaf spring.3. The device of claim 1 , wherein:the control bar defines slots extending between the slats;the slats are spaced apart from one another by the slots when the control bar is in the unloaded position; andone or more of the slots close between the slats so that adjacent ...

UPPER COMPONENT FOR AN ARTICLE OF FOOTWEAR

An upper component for an article of footwear allows easy entry of the foot into the article of footwear. The upper component includes a heel body, which includes a first portion partially defining an ankle opening. The heel body further includes a second portion coupled to the first portion. The second portion is foldable and partially defines the ankle opening. The second portion is movable relative to the first portion between an unfolded configuration and a folded configuration. The upper component includes at least one tension member coupled to the second portion. The tension member is movable relative to the first portion to move the second portion from the unfolded configuration to the folded configuration. The ankle opening is larger when the second portion is in the unfolded configuration than when the second portion is in the folded configuration. 1. An upper component for an article of footwear , comprising: an anterior body portion partially defining an ankle opening;', 'a posterior body portion coupled to the anterior body portion, wherein the posterior body portion is foldable and partially defines the ankle opening, and the posterior body portion is movable relative to the anterior body portion between an unfolded configuration and a folded configuration;, 'a heel body includingat least one tension member anchored at the posterior body portion, wherein the at least one tension member is movable relative to the anterior body portion to move the posterior body portion from the unfolded configuration to the folded configuration; andwherein the ankle opening is larger when the posterior body portion is in the unfolded configuration than when the posterior body portion is in the folded configuration.2. The upper component of claim 1 , wherein the at least one tension member includes an anterior member portion and a posterior member portion coupled to the anterior member portion claim 1 , and the posterior member portion of the at least one tension member ...

FOOTWEAR HEEL SPRING DEVICE

A device configured to surround a portion of a foot-receiving cavity at a heel region of an article of footwear comprises a control bar having a center segment, a first side arm extending from the center segment, and a second side arm spaced from the first side arm and extending from the center segment. The control bar may include a series of slats. A base supports the control bar and is connected to the first side arm and the second side arm. The control bar is biased to an unstressed position with the center segment a first distance from the base, and elastically bends under an applied force to a loaded position with the center segment a second distance from the base less than the first distance. The device stores potential energy that returns the control bar to the unloaded position upon removal of the applied load. 1. A device configured to surround a portion of a foot-receiving cavity at a heel region of an article of footwear , the device comprising:a control bar having a center segment, a first side arm extending from the center segment, and a second side arm spaced from the first side arm and extending from the center segment;a continuous base supporting the control bar and connected to both of the first side arm and the second side arm;wherein the center segment of the control bar has a ramped surface that declines toward an inner periphery of the center segment between the first side arm and the second side arm; andwherein the control bar is biased to an unstressed position with the center segment a first distance from the base, the control bar elastically deforms under an applied force to a loaded position with the center segment a second distance from the base less than the first distance, and the device stores potential energy that returns the control bar to the unstressed position upon removal of the applied force.2. The device of claim 1 , wherein the base is connected to the first side arm at a first joint claim 1 , and the base is connected to the ...

Article of Footwear With Mesh Structure

An article of footwear includes a mesh structure. The mesh structure can be formed from a plurality of cords that are arranged in a mesh pattern or can be formed using a knitting process. The mesh structure can be disposed over the upper and the sole structure.

Oleophilic lubricated catheters

A medical device wherein the device has an outer surface coated with an oleophilic lubricous coating or the device is formed from a mixture including a polymer and an oleophilic compound.

De-duplicating remote procedure calls

A method, computer program product, and a computing system are provided for de-duplicating remote procedure calls at a client. In an implementation, the method may include generating a plurality of local pending remote procedure calls. The method may also include identifying a set of duplicate remote procedure calls among the plurality of remote procedure calls. The method may also include associating each remote procedure call within the set of duplicate remote procedure calls with one another. The method may also include executing a remote procedure call of the set of duplicate remote procedure calls. The method may further include providing a response for the remote procedure call of the set of duplicate remote procedure calls with the other remote procedure calls of the set of duplicate remote procedure calls.

FOOTWEAR HEEL SPRING DEVICE

A device configured to surround a portion of a foot-receiving cavity at a heel region of an article of footwear includes a control bar having a center segment, a medial side arm extending from the center segment, and a lateral side arm spaced from the medial side arm and extending from the center segment. The device may include an extension extending toward the control bar. At least a portion of the control bar may be elastically deformable under an applied force depressing the control bar toward the extension, and the extension may limit movement of the control bar. The control bar may be adapted to return to an unloaded position upon removal of the applied force. 1. An article of footwear comprising:an upper defining a foot-receiving cavity with an ankle opening;a sole structure secured to and underlying the upper; a control bar having a center segment connected to the upper rearward of the ankle opening, a medial side arm extending downwardly and forwardly from the center segment at a medial side of the upper, and a lateral side arm extending downwardly and forwardly from the center segment at a lateral side of the upper;', 'an extension disposed in a back portion of the article of footwear and extending upwardly toward the control bar; wherein at least a portion of the control bar is elastically deformable under an applied downward force depressing the control bar toward the extension, the extension limiting downward movement of the control bar, wherein the control bar and the upper return to an unloaded position upon removal of the applied downward force; and, 'a heel spring device connected to a heel region of the upper and includingwherein the upper moves with the center segment and deforms such that the ankle opening is closer to the sole structure when the control bar is depressed than when the applied load is removed.2. The article of footwear of claim 1 , wherein the extension is centrally disposed on the back portion of the article of footwear and the ...

Hygienic medical devices having hydrophilic coatings and methods of forming the same

Hygienic Hydrophilic coatings, hydrophilic coating formulations and wetting fluids that include an anti-infective agent.

REAR ACCESS ARTICLE OF FOOTWEAR WITH MOVABLE HEEL PORTION

An article of footwear comprises a sole structure, and an upper including a front section and a rear section. The front section is fixed to a forefoot region of the sole structure and partially defines a foot-receiving cavity. The rear section is operatively secured to the sole structure at least partially rearward of the front section, and includes medial and lateral wings. A medial set of magnets includes at least one front medial magnet secured to a medial side of the front section and at least one rear medial magnet secured to the medial wing. A lateral set of magnets includes at least one front lateral magnet secured to a lateral side of the front section and at least one rear lateral magnet secured to the lateral wing. The rear section is movable relative to the front section between an access position and a use position. 1. An article of footwear comprising:a sole structure;an upper including a front section and a rear section; the front section fixed to the sole structure and partially defining a foot-receiving cavity, and the rear section rearward of the front section and including a medial wing and a lateral wing;an insole positioned within the foot-receiving cavity; anda tether coupling the insole to the rear section; the rear section articulates relative to the front section between an access position and a use position;', 'the medial wing and the lateral wing are spaced apart from the front section in the access position, and the medial wing is adjacent to the front section and the lateral wing is adjacent to the front section in the use position;', 'a rear of the insole is in a lifted position when the rear section is in the access position; and', 'the insole pulls the tether which moves the rear section from the access position to the use position when the rear of the insole is displaced downward in the foot-receiving cavity relative to the lifted position., 'wherein2. The article of footwear of claim 1 , further comprising:a fastener coupling the ...

FOOTWEAR UPPER WITH LACE-ENGAGED ZIPPER SYSTEM

A footwear upper comprises a front section and a rear section. The front section is at least partially forward of the rear section and at least partially defines a foot-receiving cavity. The front section has a medial edge and a lateral edge partially defining a foot entry opening. A zipper system includes a medial slider movable along the medial edge of the front section to zip the rear section to the medial edge, a medial zipper pull engaged with the medial slider, a lateral slider movable along the lateral edge of the front section to zip the rear section to the lateral edge, and a lateral zipper pull engaged with the lateral slider. A tightening system includes a lace-receiving feature on the front section forward of the zipper system, and a lace extending through the lace-receiving feature, through the medial zipper pull, and through the lateral zipper pull. 1. A footwear upper comprising:a front section and a rear section; the front section at least partially forward of the rear section and at least partially defining a foot-receiving cavity; the front section having a medial edge and a lateral edge partially defining a foot entry opening of the foot-receiving cavity; a medial slider movable along the medial edge of the front section to selectively zip the rear section to the medial edge of the front section;', 'a medial zipper pull engaged with the medial slider;', 'a lateral slider movable along the lateral edge of the front section to selectively zip the rear section to the lateral edge of the front section;', 'a lateral zipper pull engaged with the lateral slider;, 'a zipper system including a lace-receiving feature on the front section forward of the zipper system; and', 'a lace extending through the lace-receiving feature, through the medial zipper pull, and through the lateral zipper pull., 'a tightening system including2. The footwear upper of claim 1 , wherein the medial zipper pull claim 1 , the lateral zipper pull claim 1 , and the lace-receiving ...

FOOTWEAR HEEL SPRING DEVICE

A device configured to surround a portion of a foot-receiving cavity at a heel region of an article of footwear includes a control bar having a center segment, a medial side arm extending from the center segment, and a lateral side arm spaced from the medial side arm and extending from the center segment. The device may include an extension extending toward the control bar. At least a portion of the control bar may be elastically deformable under an applied force depressing the control bar toward the extension, and the extension may limit movement of the control bar. The control bar may be adapted to return to an unloaded position upon removal of the applied force. 1. An article of footwear comprising:an upper defining a foot-receiving cavity with an ankle opening; a control bar having a center segment connected to the upper rearward of the ankle opening, a medial side arm extending downwardly and forwardly from the center segment at a medial side of the upper, and a lateral side arm extending downwardly and forwardly from the center segment at a lateral side of the upper;', 'an extension disposed at a back portion of the article of footwear and having a tip extending upwardly toward the control bar;, 'a device connected to a heel region of the upper and includingwherein the upper has a first stiffness at a first location between the control bar and the extension, a second stiffness at a second location between the first location and the extension, and the second stiffness is less than the first stiffness;wherein at least a portion of the control bar is elastically deformable under an applied downward force depressing the control bar toward the extension, the tip of the extension deforming the upper inward toward the foot-receiving cavity at the second location; and wherein the control bar and the upper return to an unloaded position upon removal of the applied downward force.2. The article of footwear of claim 1 , wherein:the upper has a first thickness at the ...

Verfahren zum polymerisieren einer monomercharge.

A process for making an olefin polymerization catalyst

Catalizador de polimerizacion

La presente invención se refiere a una composición catalizadora que consiste esencialmente del producto obtenido por: (1) secar un óxido inorgánico que tiene grupos hidroxilo superficiales para formar un soporte que está substancialmente exente de agua absorbida; (2) hacer reaccionar los grupos hidroxilos superficiales del soporte con cuando menos una cantidad substancialmente estequiométrica de al menos un compuesto organometálico correspondiente a la fórmula RxMR' y R"z, en donde M es un metal del grupo III de la tabla periódica, R es un grupo alquilo que contiene 1 a 12 átomos de carbono, R' y R" se selecciona independientemente del grupo que consiste en H, C1, y grupo alquilo alcoxi que contiene 1 a 12 átomos de carbono, x tiene un valor de 1 a 3, e y y z representa ambos de 0 a 2, la suma de los cuales no es mayor de 3-x; y (3) hacer reaccionar el soporte tratado de esta manera con cuando menos aproximadamente 0.001 moles, por mol de compuesto organometálico, de cuando menos un componente de vanadio correspondiente a una fórmula seleccionada de (RO)nVOX3-3 y (RO)mVX4-m, en cuyas fórmulas R representa un radical de hidrocarburo monovalente de C1-C18 que está exento de insaturación alifática, X es C1 o Br, n tiene un valor de 0 a 3, y m tiene un valor de 0 a 4; y (4) hacer reaccionar el producto de la etapa 3 con cuando menos aproximadamente 0.1 mol, por mol de compuesto organometálico, de un alcohol que contiene 1 a 18 átomos de carbono.

Aminoplast resins, dispersions, and low flammability cellular and non-cellular polyurethane products prepared therefrom

Aminoplast resin is prepared by reacting urea or melamine with formaldehyde in the presence of a stabilizer compound. Dispersions of the resin in a polyol reacted with a polyisocyanate produce polyurethane products having low flammability properties.

Implantable distraction device

A subcutaneously implantable distraction device comprises a first arm, having a first skeletal connector for attachment to a first skeletal component at a first location. A second arm has a second skeletal connector for attachment to a second skeletal component at a second location. The first and second arms are slidably moveable with respect to each other. A fluid actuator is associated with each of the first and second arms to apply a separating force between the arms to slidably move at least one of the arms relative to the other.

Mocvd precursors based on organometalloid ligands

Medical devices having a temporary radiopaque coating

A medical device comprising radiopaque water-dispersible metallic nanoparticles, wherein the nanoparticles are released from the medical device upon implantation of the device. The medical device of the present invention is sufficiently radiopaque for x-ray visualization during implantation, but loses its radiopacity after implantation to allow for subsequent visualization using more sensitive imaging modalities such as CT or MRI. The nanoparticles are formed of a metallic material and have surface modifications that impart water-dispersibility to the nanoparticles. The nanoparticles may be any of the various types of radiopaque water-dispersible metallic nanoparticles that are known in the art. The nanoparticles may be adapted to facilitate clearance through renal filtration or biliary excretion. The nanoparticles may be adapted to reduce tissue accumulation and have reduced toxicity in the human body. The nanoparticles may be applied directly onto the medical device, e.g., as a coating, or be carried on the surface of or within a carrier coating on the medical device, or be dispersed within the pores of a porous layer or porous surface on the medical device. The medical device itself may be biodegradable and may have the nanoparticles embedded within the medical device itself or applied as or within a coating on the biodegradable medical device. The nanoparticles may be released by diffusion through the carrier coating, disruption of hydrogen bonds between the nanoparticles and the carrier coating, degradation of the nanoparticle coating, degradation of the carrier coating, diffusion of the nanoparticles from the medical device, or degradation of the medical device carrying the nanoparticles.

Medical devices with coatings for delivery of a therapeutic agent

Described herein are implantable coated medical devices, such as intravascular stents, for delivering therapeutic agents to the body tissue of a patient, and methods for making such medical devices. In particular, described herein are implantable coated medical devices comprising a substrate having a surface, and a coating disposed upon the surface that comprises a coating composition that includes a releasable metal oxide. The coating is free of polymer or a particular type of polymer that is not a part of any releasable metal oxide.

Drug-Eluting Endoprosthesis

A drug-eluting endoprosthesis that includes a bioerodible metal portion and a therapeutic agent. In some aspects, the endoprosthesis includes a plurality of discrete deposits and a plurality of overlying layers each overlying one of the plurality of discrete deposits. Each discrete deposit includes one or more therapeutic agents and each overlying layer includes one or more bioerodible metals. In other aspects, the bioerodible metal portion includes at least two bioerodible metal regions having different electronegativities. The at least two bioerodible metal regions being in electrical contact with each other. The bioerodible metal erodes in a physiological environment to release the therapeutic agent.

Porous medical device and methods of use

A medical system including a tube defining a lumen, a porous body connected to a distal end of the tube to be advanced to a target site within a subject. The porous body defines a plurality of openings, the plurality of openings are in fluid connection with the lumen, the porous body includes a first material and a second material, and the second material elutes from the porous body in the subject.

Crossing network utilizing satisfaction density profile with price discovery features

A crossing network that matches buy and sell orders based upon a satisfaction and quantity profile includes a number of trader terminals that can be used for entering orders. The orders are entered in the form of a satisfaction density profile that represents a degree of satisfaction to trade a particular instrument at various (price, quantity) combinations. Typically, each order is either a buy order or a sell order. The trader terminals are coupled to a matching controller computer. The matching controller computer can receive as input the satisfaction density profiles entered at each one of the trading terminals. The matching controller computer matches orders (as represented by each trader's satisfaction density profile) so that each trader is assured that the overall outcome of the process (in terms of average price and size of fill) has maximized the mutual satisfaction of all traders. Typically, the matching process is anonymous. The matching process can be continuous or a batch process, or a hybrid of the two. Unmatched satisfaction density profiles can be used to provide spread and pricing information. Factors other than price and quantity also may be used to determine the degree of satisfaction. Optionally, priority may be given to certain profiles in the matching process to accommodate stock exchange rules, for example, requiring that priority be given to orders exhibiting the best price, regardless of size or any other consideration.

Crossing network utilizing satisfaction density profile

A crossing network that matches buy and sell orders based upon a satisfaction and quantity profile is disclosed. The crossing network includes a number of trader terminals that can be used for entering order. The orders are entered in the form of a satisfaction density profile that represents a degree of satisfaction to trade a particular instrument at various (price, quantity) combinations. Typically, each order is either a buy order or a sell order. The trader terminals are coupled to a matching controller computer. The matching controller computer can receive as input the satisfaction density profiles entered at each one of the trading terminals. The matching controller computer matches orders (as represented by each trader's satisfaction density profile) so that each trader is assured that the overall outcome of the process (in terms of average price and size of fill) has maximized the mutual satisfaction of all traders. Typically, the matching process is anonymous. The matching process can be continuous or a batch process, or a hybrid of the two. Unmatched satisfaction density profiles can be used to provide spread and pricing information. Factors other than price and quantity also may be used to determine the degree of satisfaction. Optionally, priority may be given to certain profiles in the matching process to accommodate stock exchange rules, for example, requiring that priority be given to orders exhibiting the best price, regardless of size or any other consideration. The crossing network has utility both in the securities industry and for non-securities industry applications.

Crossing network utilizing satisfaction density profile

A crossing network that matches buy and sell orders based upon a satisfaction and quantity profile is disclosed. The crossing network includes a number of trader terminals that can be used for entering orders. The orders are entered in the form of a satisfaction density profile that represents a degree of satisfaction to trade a particular instrument at various (price, quantity) combinations. Typically, each order is either a buy order or a sell order. The trader terminals are coupled to a matching controller computer. The matching controller computer can receive as input the satisfaction density profiles entered at each one of the trading terminals. The matching controller computer matches orders (as represented by each trader's satisfaction density profile) so that each trader is assured that the overall outcome of the process (in terms of average price and size of fill) has maximized the mutual satisfaction of all traders. Typically, the matching process is anonymous. The matching process can be continuous or a batch process, or a hybrid of the two. Unmatched satisfaction density profiles can be used to provide spread and pricing information. Factors other than price and quantity also may be used to determine the degree of satisfaction. Optionally, priority may be given to certain profiles in the matching process to accommodate stock exchange rules, for example, requiring that priority be given to orders exhibiting the best price, regardless of size or any other consideration. The crossing network has utility both in the securities industry and for non-securities industry applications.

Crossing network utilizing satisfaction density profile

Crossing network utilizing satisfaction density profile

A crossing network that matches buy and sell orders based upon a satisfaction and quantity profile is disclosed. The crossing network includes a number of trader terminals that can be used for entering orders. The orders are entered in the form of a satisfaction density profile that represents a degree of satisfaction to trade a particular instrument at various (price, quantity) combinations. Typically, each order is either a buy order or a sell order. The trader terminals are coupled to a matching controller computer. The matching controller computer can receive as input the satisfaction density profiles entered at each one of the trading terminals. The matching controller computer matches orders (as represented by each trader's satisfaction density profile) so that each trader is assured that the overall outcome of the process (in terms of average price and size of fill) has maximized the mutual satisfaction of all traders. Typically, the matching process is anonymous. The matching process can be continuous or a batch process, or a hybrid of the two. Unmatched satisfaction density profiles can be used to provide spread and pricing information. Factors other than price and quantity also may be used to determine the degree of satisfaction. Optionally, priority may be given to certain profiles in the matching process to accommodate stock exchange rules, for example, requiring that priority be given to orders exhibiting the best price, regardless of size or any other consideration. The crossing network has utility both in the securities industry and for non-securities industry applications.

Cross network employing profile of satisfaction density

A crossing network that matches buy and sell orders based upon a satisfaction and quantity profile is disclosed. The crossing network includes a number of trader terminals that can be used for entering orders. The orders are entered in the form of a satisfaction density profile that represents a degree of satisfaction to trade a particular instrument at various (price, quantity) combinations. Typically, each order is either a buy order or a sell order. The trader terminals are coupled to a matching controller computer. The matching controller computer can receive as input the satisfaction density profiles entered at each one of the trading terminals. The matching controller computer matches orders (as represented by each trader's satisfaction density profile) so that each trader is assured that the overall outcome of the process (in terms of average price and size of fill) has maximized the mutual satisfaction of all traders. Typically, the matching process is anonymous. The matching process can be continuous or a batch process, or a hybrid of the two. Unmatched satisfaction density profiles can be used to provide spread and pricing information. Factors other than price and quantity also may be used to determine the degree of satisfaction. Optionally, priority may be given to certain profiles in the matching process to accommodate stock exchange rules, for example, requiring that priority be given to orders exhibiting the best price, regardless of size or any other consideration. The crossing network has utility both in the securities industry and for non-securities industry applications.

Crossing network utilizing satisfaction density profile

A crossing network that matches buy and sell orders based upon a satisfaction and quantity profile is disclosed. The crossing network includes a number of trader terminals that can be used for entering orders. The orders are entered in the form of a satisfaction density profile that represents a degree of satisfaction to trade a particular instrument at various (price, quantity) combinations. Typically, each order is either a buy order or a sell order. The trader terminals are coupled to a matching controller computer. The matching controller computer can receive as input the satisfaction density profiles entered at each one of the trading terminals. The matching controller computer matches orders (as represented by each trader's satisfaction density profile) so that each trader is assured that the overall outcome of the process (in terms of average price and size of fill) has maximized the mutual satisfaction of all traders. Typically, the matching process is anonymous. The matching process can be continuous or a batch process, or a hybrid of the two. Unmatched satisfaction density profiles can be used to provide spread and pricing information. Factors other than price and quantity also may be used to determine the degree of satisfaction. Optionally, priority may be given to certain profiles in the matching process to accommodate stock exchange rules, for example, requiring that priority be given to orders exhibiting the best price, regardless of size or any other consideration. The crossing network has utility both in the securities industry and for non-securities industry applications.

Method and apparatus for automating negotiations between parties

A system calculates the mutual satisfaction between negotiating parties and maximizes their mutual satisfaction over a range of decision variables and does so without requiring the parties to identify themselves and their positions to each other. For automatically negotiating agreements between multiple parties, a computer accepts a satisfaction function from an offering party who defines his degree of satisfaction to agree to a range of terms upon which the party is desirous of negotiating as a function of the relevant decision variables. The computer then accepts input from all other parties regarding their degree of satisfaction to agree to each of the terms as a function of a particular relevant decision variable. The computer then calculates a satisfaction function for each of these terms based on all of the individual inputs. Next, the computer calculates a joint satisfaction function for all of the terms as a function of the particular relevant decision variable, and then calculates the mutual satisfaction function for the offering party and the other parties, also as a function of the particular relevant decision variable. Finally, the computer calculates the set of decision variable yielding the maximum mutual satisfaction and provides this output to the parties.

Treatment of cancers of the blood using selected glycomimetic compounds

Methods and medicaments therefor are provided for the treatment of cancers of the blood or a complication therewith in an individual. More specifically, the use of particular glycomimetics for the treatment is described. Methods and medicaments therefor are also provided without regard to cancer type for reducing in an individual the myeloablative bone marrow toxicities of chemotherapy.

Footwear heel spring device

A device configured to surround a portion of a foot-receiving cavity at a heel region of an article of footwear includes a control bar having a center segment, a medial side arm extending from the center segment, and a lateral side arm spaced from the medial side arm and extending from the center segment. The device may include an extension extending toward the control bar. At least a portion of the control bar may be elastically deformable under an applied force depressing the control bar toward the extension, and the extension may limit movement of the control bar. The control bar may be adapted to return to an unloaded position upon removal of the applied force.

Endoprosthesis with porous reservoir and non-polymer diffusion layer

An endoprosthesis such as a coronary stent includes a porous reservoir of drug, e.g., a porous layer formed of a ceramic and an overlayer formed of ceramic or metal for controlling elution of drug from the reservoir.

Drug-delivery balloons

Drug-delivery balloons, as well as related medical devices and methods, are disclosed.

Balloon catheters with fibers for delivery of therapeutic agent and methods of making the same

A medical device comprises a catheter with an expandable member, fibers extending from the outer surface of the expandable member, and therapeutic agent coated on the fibers or carried in the spaces between the fibers. Upon expansion of the expandable member, the therapeutic agent is delivered from the medical device. A surfactant may be coated on the fibers. A method of manufacturing comprises coating the outer surface of an expandable member with a metallic layer, coating the metallic layer with at least one polymeric layer, forming a plurality of holes in at least one polymeric layer, forming fibers in the holes, and removing at least one polymeric layer.

Water disintegrable flushable catheter with a hydrophilic coating

This is a water disintegrable, flushable catheter that will dissolve or biodegrade in water. It is coated with a hydrophilic coating and will achieve lubricity values typical of a hydrophilic catheter. The catheter may be formed of a bi-layer tube that has a biodegradable outer layer such as polylactic acid and a purely water disintegrable inner layer, e.g., polyvinyl alcohol (PVOH). The outer layer will support the hydrophilic coating even when it's wetted and thus acts as a stable primer layer for hydrophilic style coatings. The outer layer bonds well to the water disintegrable inner layer but also allows a hydrophilic coating to be applied on top. The outer layer acts as a temporary water barrier. This water barrier allows the hydrophilic coating to be hydrated prior to use but prevents water molecules from attacking the PVOH inner layer. Alternatively, a hydrophilic coating that bonds to either the tubing directly or a via a primer layer but unlike typical hydrophilic coatings the coating is pre- activated by organic activation agents other than water and thus the catheter does not break down in the packaging or sterilization

Covered walkway system for a parking lot

A covered walkway system for a parking lot of a store such as a supermarket having a covered walkway across the front of the store, covered branch walkways extending out from the cross walkway into the lot, parking spaces marked off at opposite sides of the branch walkwavs, and covered corrals for shopping carts extending out from the sides of the branch walkways.

Electronic credit default futures market

Systems and methods are provided for providing a credit default futures market. A system providing the credit default futures market includes a processor, memory and an interface. The interface is configured to display credit default futures contracts that subscribe to a set of standard terms and conditions. The processor is configured to settle certain credit futures contracts in kind and other in cash, depending on, at least in part, the maturity date of the futures contract. A method is presented for electronically clearing and settling probability of default futures contracts.

Packer

Water disintegrable flushable catheter with a hydrophilic coating

This is a water disintegrable, flushable catheter that will dissolve or biodegrade in water. It is coated with a hydrophilic coating and will achieve lubricity values typical of a hydrophilic catheter. The catheter may be formed of a bi-layer tube that has a biodegradable outer layer such as polylactic acid and a purely water disintegrable inner layer, e.g., polyvinyl alcohol (PVOH). The outer layer will support the hydrophilic coating even when it's wetted and thus acts as a stable primer layer for hydrophilic style coatings. The outer layer bonds well to the water disintegrable inner layer but also allows a hydrophilic coating to be applied on top. The outer layer acts as a temporary water barrier. This water barrier allows the hydrophilic coating to be hydrated prior to use but prevents water molecules from attacking the PVOH inner layer. Alternatively, a hydrophilic coating that bonds to either the tubing directly or a via a primer layer but unlike typical hydrophilic coatings the coating is pre- activated by organic activation agents other than water and thus the catheter does not break down in the packaging or sterilization

Disposal of fine tailings

A method of disposal of slurries of fine tailings material comprising construction of a bund, forming a first drainage means underneath said bund and over the area to be covered by said fine tailings adjacent said bund and over the face of the bund to be covered by said fine tailings, depositing the slurries of fine tailings in layers behind said bund and providing second drainage means between said layers in the region adjacent said bund.

COATED LITHIUM, METHOD FOR COATING METALLIC LITHIUM AND ENERGY SOURCE USING COATED LITHIUM.

RAZOR HANDLE HAVING A LOCKING DEVICE FOR PIVOTING CARTRIDGES

LE MANCHE 12 DU RASOIR COMPORTE UNE PROJECTION EN PORTE A FAUX 50 SE TERMINANT PAR UN CHIEN 54. LA CARTOUCHE DE LAMES DE RASOIR 10 PIVOTE AU-DESSUS ET AU-DESSOUS D'UNE POSITION ANGULAIRE NEUTRE A. LORSQUE LE PIVOTEMENT ATTEINT LA POSITION ANGULAIRE -A, LE CANAL 23 DE LA CARTOUCHE APPUIE SUR LA SURFACE DE CAME 56 DU CHIEN 54 EN REPOUSSANT ELASTIQUEMENT LE VERROU 50, QUI REVIENT ENSUITE EN POSITION, EN EMPRISONNANT LE BORD EXTERNE DUDIT CANAL 23. LA CARTOUCHE ETANT AINSI IMMOBILISEE, LE RASOIR PEUT ETRE UTILISE POUR DES OPERATIONS PRECISES. POUR DEVERROUILLER LA CARTOUCHE, IL SUFFIT D'EXERCER UNE FORCE MANUELLE SUFFISANTE. SHAFT HANDLE 12 FEATURES A 50 FALSE GATE PROJECTION ENDING IN A DOG 54. RAZOR BLADE CARTRIDGE 10 PIVOTS ABOVE AND BELOW A NEUTRAL ANGULAR POSITION A. WHEN PIVOT REACHES ANGULAR POSITION -A, THE CHANNEL 23 OF THE CARTRIDGE PRESSES ON THE CAM SURFACE 56 OF THE DOG 54 BY ELASTICALLY PUSHING THE LATCH 50, WHICH THEN RETURNS INTO POSITION, ENTRACTING THE OUTER EDGE OF THE SAID CHANNEL 23. THE CARTRIDGE IS THUS IMMOBILIZED, THE RAZOR CAN BE IMMOBILIZED TO BE USED FOR PRECISE OPERATIONS. TO UNLOCK THE CARTRIDGE, SUFFICIENT MANUAL FORCE IS SUFFICIENT.

Method and device for the purification of liquids

AUTOMATIC PURGE CENTRIFUGE

L'INVENTION CONCERNE UNE CENTRIFUGEUSE A PURGE AUTOMATIQUE POUR FLUIDES CONTAMINES CONTENANT UN LIQUIDE LEGER, UN LIQUIDE PLUS LOURD ET DES PARTICULES SOLIDES. LA CENTRIFUGEUSE COMPREND UN TAMBOUR 11 POURVU D'UNE PAROI LATERALE 12 ET D'UNE PAROI SUPERIEURE 13, UN ROTOR COMPORTANT DES DISQUES EMBOITES 22, 24, 25, ESPACES L'UN DE L'AUTRE PAR DES ENTRETOISES 21 ET MUNIS D'ORIFICES 23 DE PASSAGE DE LIQUIDE LEGER, LA PAROI SUPERIEURE 13 DU TAMBOUR 11 COMPORTANT DES PARTIES MUNIES D'ORIFICES INTERIEURS 46 ET D'ORIFICES EXTERIEURS 52 DE DECHARGE DE LIQUIDE, UNE CHICANE ANNULAIRE 45 DIRIGEE VERS LE BAS A PARTIR DE LA PAROI SUPERIEURE 13 ENTRE LES ORIFICES INTERIEURS ET EXTERIEURS 46, 52, UN ELEMENT DE PROLONGEMENT 50 PLACE SUR LE TAMBOUR POUR EMPECHER DU FLUIDE ET DES PARTICULES SOLIDES DE PENETRER DANS LES ORIFICES DE DECHARGE DE LIQUIDE PENDANT UN CYCLE DE PURGE, UN FREIN PNEUMATIQUE 55 POUR RALENTIR LA ROTATION DU TAMBOUR AFIN D'AMORCER UN CYCLE DE PURGE ET DES TIGES DE PURGE 65 QUI SERVENT A PROVOQUER UNE PERTURBATION DE L'ECOULEMENT DE LIQUIDE CONTAMINE PENDANT LE CYCLE DE PURGE. L'INVENTION S'APPLIQUE AUX USINES DE TRAVAIL DES METAUX.

CARTRIDGE OF RAZOR BLADES WITH INCORPORATED CLEANING BLADE

Bottle-washer.

Coin-controlled apparatus for locking shopping carts together

Coin-controlled apparatus (3) for locking shopping carts (C1?, C2?, C3?) together in nested series at a cart parking station having coin-controlled mechanism (3) mounted on a cart, e.g. on the handle (H) of the cart, which is adapted for receiving and releasably locking therein a latch bar (5) on a tether (7) which is attached to the next cart in the nested series, requiring deposit of a coin (Q) to release the latch bar (5) to free the cart for being wheeled away by the user, and holding the coin (a) until the user brings the cart back to a cart parking station, nests it in the end cart at the parking station, and inserts the latch bar (5) which is tethered to said end cart in the mecahism (3) to lock the returned cart to the series and to provide for return of the user's coin.

Internal combustion engine control means

There is disclosed an automatic control system for limiting the operating temperature of a diesel engine (10) having a shut down lever (52) that repositions the rack of its fuel pump (12) to a shut down position that closes the pump metering valves and shuts off the fuel supply to the engine. The system includes a pyrometer (24) to sense the exhaust gas temperature from the engine and generate a signal therefrom, a temperature controller (30) having an adjustable, maximum set point temperature to receive the signal from the pyrometer (24) and to generate a control signal which is applied to a control valve (102) in a fluid pressure line (99) which applies fluid pressure to a pressure responsive actuator (82) that moves the shut down lever (52) a fraction of its full travel necessary for shut down and thereby repositions the fuel pump rack to a throttling position in response to a sensed exhaust gas temperature which exceeds the preselected maximum set point temperature.

Ignition apparatus

ONE-PIECE RAZOR HANDLE

LE MANCHE 12 EST CONSTITUE DE DEUX PAROIS LATERALES OPPOSEES 36 REUNIES, DE BAS EN HAUT, PAR UNE BASE 42, UNE ENTRETOISE 44 ET UN COL 46. LES PAROIS 36 SE TERMINENT PAR DES PARTIES DIVERGENTES 50 PORTANT DES MOYENS D'ACCOUPLEMENT 58 ADAPTES A VENIR EN PRISE AVEC UNE CARTOUCHE DE LAME(S) 10. LE MANCHE ETANT EN MATIERE PLASTIQUE ELASTIQUE, IL EST POSSIBLE, EN LE SERRANT ENTRE L'ENTRETOISE 44 ET LE COL 46, DE PROVOQUER L'ECARTEMENT DES PARTIES 50 (POSITION DE DESACCOUPLEMENT D'AVEC LA CARTOUCHE). LORSQUE L'ON CESSE DE SERRER, LES PARTIES 50 SE RAPPROCHENT (POSITION D'ACCOUPLEMENT AVEC LA CARTOUCHE). HANDLE 12 CONSISTS OF TWO OPPOSITE SIDE WALLS 36 JOINED, FROM BOTTOM UP, BY A BASE 42, A SPACER 44 AND A NECK 46. THE WALLS 36 END WITH DIVERGENT PARTS 50 CARRYING COUPLING MEANS 58 ADAPTED TO COME INTO HOLD WITH A BLADE CARTRIDGE (S) 10. THE HANDLE IS IN ELASTIC PLASTIC MATERIAL, IT IS POSSIBLE, BY TIGHTENING IT BETWEEN THE SPACER 44 AND THE NECK 46, TO CAUSE THE SPACING OF THE PARTS 50 (DISCONNECT POSITION WITH THE CARTRIDGE). WHEN YOU STOP TIGHTENING, THE PARTS 50 MOVE TOGETHER (COUPLING POSITION WITH THE CARTRIDGE).

CARTRIDGE OF RAZOR BLADES WITH INCORPORATED CLEANING BLADE

LA CARTOUCHE COMPREND AU MOINS DEUX LAMES ECARTEES 31, 32 AYANT DES ARETES DE COUPE, UNE LAMELLE MOBILE 34 PRISE EN SANDWICH ENTRE LES LAMES 31, 32 POUR DEBARRASSER CES DERNIERES DES DEBRIS DE RASAGE, UN COUVERCLE 14 REUNI EN PERMANENCE A LA CARTOUCHE DE LAMES ET POUVANT ETRE DEPLACE D'AVANT EN ARRIERE PAR RAPPORT A LADITE CARTOUCHE ET DES MOYENS REALISANT UNE LIAISON D'ENTRAINEMENT ENTRE LE COUVERCLE 14 ET LADITE LAMELLE 34 POUR ENTRAINER CETTE DERNIERE LORSQUE LE COUVERCLE 14 EST DEPLACE DANS UNE DIRECTION PREDETERMINEE. THE CARTRIDGE INCLUDES AT LEAST TWO SPACED BLADES 31, 32 WITH CUTTING EDGES, A MOVABLE BLADE 34 TAKEN AS A SANDWICH BETWEEN THE BLADES 31, 32 TO REMOVE THESE LATEST SHAVING DEBRIS, A COVER 14 PERMANENTLY ASSEMBLED WITH THE CARTRIDGE AND MAY BE MOVED FRONT AND BACK WITH RESPECT TO THE SAID CARTRIDGE AND THE MEANS ACHIEVING A DRIVE LINK BETWEEN THE COVER 14 AND THE SAID SHEATH 34 TO DRIVE THIS LATEST WHEN THE COVER 14 IS MOVED IN A PREDETERMINED DIRECTION.

Coring and drilling device

Anodizinc means and techniques

Pneumatic dispatch tube apparatus

Method of obtaining derivatives of benzazepine and benzothiazepine

Vasodilating activity is exhibited by compounds having the formula <IMAGE> wherein X can be -S-or -CH2-; and R2 is <IMAGE> <IMAGE> <IMAGE> <IMAGE> depending upon the definition of X.

Glider

Polyether hydroxysulfonate surface active agents

Method for the preparation of noncellular, filled thermoset castings having superior mechanical properties

Abstract of the Disclosure By using a polyether polyol grafted with a suitable proportion of a suitable vinyl-type monomer with the use of a free-radical catalyst, it is possible to obtain filled or unfilled castings of thermosetting polyurethane which has excellent physical properties as well as good processing characteristics.

Process of reclaiming a liquid organic solvent from a foam contaminant

THE PROCESS OF RECLAIMING A LIQUID ORGANIC SOLVENT FROM A FOAM CONTAMINANT CONSISTING OF A SYNTHETIC POLYMER MIXED WITH A CATALYST TO FORM A FOAM, IN WHICH A QUANTITY OF LIQUID IS PLACED INTO A STILL POT, THE LIQUID BEING ONE THAT HAS A BOILING POINT THAT IS GREATER THAN THAT OF THE SOLVENT, AND FEEDING THE SOLVENT AND FOAM CONTAMINAT MIXTURE INTO THE STILL POT LIQUID THAT HAS BEEN HEATED TO A TEMPERATURE ABOVE THE BOILING POINT OF THE SOLVENT YET BELOW THE BOILING POINT OF THE LIQUID WHEREBY THE SOLVENT VAPORIZES, THE SOLVENT VAPOR BEING PASSED THROUGH A CONDENSER AND THE RESULTANT SOLVENT LIQUID BEING RECOVERED. THE SOLVENT CAN BE A CHLORINATED SOLVENT OF A CLASS INCLUDING METHYLENE CHLORIDE, TRICHLOROETHYLENE AND METHYL CHLOROFORM, THE STILL POT LIQUID CAN BE WATER, AND THE FOAM CONTAMINANT CAN BE OF A CLASS INCLUDING POLYURETHANE FOAM AND POLYESTYRENE FOAM. THE SOLVENT AND FOAM CONTAMINANT MIXTURE IS FED INTO THE HEATED WATER ABOVE THE LIQUID LEVEL AND AT A RATE DETERMINTED BY THE CAPACITY OF THE CONDENSER. THE AMOUNT OF WATER PROVIDES SUFFICIENT DEPTH TO COVER THE BATCH OF SOLVENT AND CONTAMINANT MIXTURE FED INTO THE POT, THE FOAM CONTAMINANT BEING REMOVED PHYSICALLY FROM THE WATER AFTER THE WOLVENT HAS BEEN VAPORIZED FROM THE BATCH. THE SOLVENT VAPOR, TOGETHER WITH A MINOR AMOUNT OF WATER VAPOR, IS DELIVERED INTO A SETTLING TANK, THE WATER BEING LIGHTER THAN THE SOLVENT LIQUID O PROVIDE A COVERING LAYER IN THE SETTLING TANK TO PREVENT EVAPORATION OF THE SOLVENT LIQUID. THE SOLVENT LIQUID IS DRAWN FROM THE SETTLING TANK AND PASSED THROUGH A DESICCANT TO REMOVE ANY REMAINING QUANTITY OF WATER.

Aminothiazole inhibitors of cyclin dependent kinases

Method of making porous metal structures

Long emission wavelength chemiluminescent compounds and their use in test assays

ABSTRACT An assay method incorporating at least two different chemiluminescent compounds for detection and/or quantitation of at least two substances in a test sample is described. The synthesis of chemiluminescent reagents or conjugates for use in such methods as well as kits incorporating such reagents are also disclosed. The assays have particular application in the field of clinical diagnostics.

Selectively water disintegrable materials and catheters made of such materials

Polymeric materials that are blends of polymers having differing water solubility rates are disclosed. The blends may be incorporated into at least a portion of a medical devices such as the shafts of flushable urinary catheters to provide suitable catheter stiffness/flexibility and catheter disintegration in water receptacles such as toilets. The blended material may provide the substrate of the catheter shaft or may provide one or more layers of the catheter.

Periodontal probe system

PERIODONTAL PROBE SYSTEM ABSTRACT A periodontal probe system for measurement, storage, and display of periodontal pocket depth, gingival level and periodontal attachment level of the teeth. In the system, a periodontal probe instrument includes an elongate tip with a measurement arrangement that simultaneously measures periodontal pocket depth, gingival level, and periodontal attachment level at each of a plurality of probe sites around a tooth. The measurement arrangement provides depth signals indicative of the pocket depth and attachment level measured. Gingival level is computed as the arithmetic difference between the attachment level and the pocket depth. A pressure sensor in the probe provides a pressure signal indicative of the pressure acting on the tip of the probe. A signal processing apparatus is connected to receive the pressure signal and the depth signals. A periodontal measurement is made by inserting the tip of the probe into a gum pocket and gradually increasing the pressure on the probe tip after insertion. At a predetermined pressure level, the signal processing apparatus samples the depth signals and converts them into measurement signals corresponding to pocket depth and attachment level. The signal processor accumulates measurement signals in an examination file format. A display apparatus responds to converted depth signals by displaying pocket depth, gingival level, and attachment level for the tooth being measured in a dental chart format. In the primary embodiment, the measurement arrangement [ORILPA.H17] includes an array of opto-electronic elements disposed on the probe tip and an optical shield slidably disposed on the probe tip over the array of opto-electrical elements. When the probe tip is inserted into a gum pocket, the optical shield engages the crown of the tooth, serving as a reference point while the tip is moved into the pocket. The ambient lighting of the high-intensity dental examination lamp illuminates the probe tip, ...

Counter

Oleophilic lubricated catheters

A urinary catheter, comprising: a catheter tube having an outer surface; and an oleophilic composition comprising oleic acid and glycerol esters thereof for use as a lubricant or lubricious composition for the urinary catheter disposed on the outer surface of the catheter tube, wherein the lubricant or lubricious composition has a coefficient of friction of less than 0.45.

Method of manufacture

Foamed polymers containing low molecular weight urethane modifier compound

Foamed polymers such as polyurethanes useful, for instance, as cushioning, insulation, and in reaction injection molding to produce thin section moldings can be produced without substantial reduction in physical properties by the incorporation therein of about 2 percent to about 75 percent by weight based upon the weight of said polymer of at least one non-reactive, liquid urethane modifier compound processing aid or flame-retardant additive. Said modifier has a low viscosity at ambient temperatures and is a low-molecular weight urethane adduct formed by the reaction of (1) at least one polyisocyanate and at least one monohydric alcohol or (2) at least one monofunctional isocyanate with at least one monohydric or polyhydric alcohol or (3) at least one isocyanate-terminated quasi-prepolymer with at least one monohydric alcohol. Said modifier can also consist of mixtures of (1), (2), and (3). Utilizing halogenated alcohols, flame-retardant polymer foams such as polyurethane foams can be prepared. Unexpectedly, microcellular, rigid, high-resilience, and flexible foamed polyurethanes can be prepared utilizing substantial proportions, such as flame-retardant amounts, of the modifier compound without substantial reduction in physical properties of the foam.

Apparatus for feeding glass parts

Pyridazine-3-sulphonamide derivatives; preparation and pharmaceutical compositions

Analogous Process for Preparation of Therapeutically Active Benzazepine and Benzothiazepine Derivatives

Phenolic polyols and rigid cellular compositions derived therefrom

Modified benzyl ether-containing resole polyols derived from phenol, paraformaldehyde and an aliphatic hydroxyl compound are prepared using a metal derivative as a catalyst. These polyols react with organic polyisocyanates to yield closed cell, low friability, low combustibility, rigid polyurethane foams without the need for post curing at elevated temperature. They are also useful in the preparation of modified rigid polyisocyanurate foams.

Electrostatic paint spray

Methods of selectively modifying the flexibility of medical tubes

Methods of varying the stiffness of polymeric medical tubes.

Optical projection

CYCIN-DEPENDENT PROTEIN KINASE INHIBITORS AMINOTIAZOLE-DERIVED COMPOUNDS

La presente invención se refiere a los compuestos de la fórmula:y a las sales de los mismos aceptables farmacéuticamente. Cuando se utilizan en la fórmula I, y en toda la especificación, los símbolos tienen los siguientes significados; R1 y R2 son independientemente hidrógeno, flúor o alquilo,R3 es arilo o heteroarilo; R4 es hidrógeno, alquilo, cicloalquilo, arilo, cicloalquilalquilo, aril-alquilo, heteroarilo, heteroarilalquilo, heterocicloalquilo, heterociclo- alquilalquilo; o CO-alquilo, CO-cicloalquilo, CO-arilo, CO-alquil- cicloalquilo, CO-alquilarilo, CO-heteroarilo, CO-alquil-heteroarilo, CO-heterocicloalquilo, CO-alquil-heterocicloalquilo; o CONH-alquilo, CONH-cicloalquilo, CONH-arilo, CONH-alquil-cicloalquilo, CONH-alquil-arilo, CONH-heteroarilo, CONH-alquil-heteroarilo, CONH-heterocicloalquilo, CONH-alquil- heterocicloalquilo; o COO-alquilo, COO-cicloalquilo, COO-arilo, COO-alquil-cicloalquilo, COO-alquil-arilo, COO-heteroarilo, COO-alquil- heteroarilo, COO-heterocicloalquilo, COO-alquil- heterocicloalquilo; o SO2 -alquilo, SO2 -cicloalquilo, SO2 -arilo, SO2 -alquil-cicloalquilo, SO2 -alquilarilo, SO2 -heteroarilo, SO2 -alquil-heteroarilo, SO2 -heterocicloalquilo, SO2 -alquil-heterociclo-alquilo; o C(NCN)NH-alquilo, C(NCN)NH-cicloalquilo, C(NCN)NH-arilo, C(NCNNH)-alquilcicloalquilo, C(NCN)NH-alquil-arilo, C(NCN)NH-heteroarilo, C(NCN)NH-alquilheteroarilo, C(NCN)NH-heterociclo-alquilo, C(NCN)NH-alquil-heterocicloalquilo; o C(NNO2 )NH-alquilo, C(NNO2 )NH-cicloalquilo, C(NNO2 )NH-arilo, C(NNO2 )NH-alquilcicloalquilo, ... The present invention relates to compounds of the formula: and pharmaceutically acceptable salts thereof. When used in formula I, and throughout the specification, the symbols have the following meanings; R1 and R2 are independently hydrogen, fluoro or alkyl, R3 is aryl or heteroaryl; R4 is hydrogen, alkyl, cycloalkyl, aryl, cycloalkylalkyl, aryl-alkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl; or CO-alkyl, CO- ...

Heterobifunctional compounds for selectin inhibition

Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise glycomimetics linked to a compound, for example a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).

Porous metal article

Flushable catheters

A flushable catheter assembly includes a catheter shaft having proximal and distal end portions. The catheter may include a funnel assembly associated with the distal end portion of the catheter shaft and/or an introducer cap assembly associated with the proximal end portion of the catheter shaft. A groove is defined along at least a portion of an outer perimeter of the funnel assembly or introducer cap assembly, with the groove being configured to receive at least a portion of the catheter shaft for wrapping the catheter shaft around the outer perimeter when disposing of the catheter. Instead of (or in addition to) a groove, one or more channels may pass through the funnel assembly to receive a portion of the catheter shaft for securing the catheter shaft to the funnel assembly for disposal. The catheter assembly and/or its individual components may be formed of a water disintegrable material.

Oscilloscope display for plotting device

The specification describes an oscilloscope display for binary signals being plotted on a mechanical plotting device. A control circuit for the oscilloscope is disclosed which blanks the oscilloscope beam if either the pen of the mechanical plotting device is up or if the device is not plotting.

Method for producing sulphonamide type endotheline antagonists and medical preparatives containing them

Coin-controlled apparatus for locking shopping carts together

Coin-controlled apparatus for locking shopping carts together in nested series at a cart parking station having a coin-controlled mechanism mounted on a cart, e.g. on the handle of the cart, which is adapted for receiving and releasably locking therein a latch bar on a tether which is attached to the next cart in the nested series, requiring deposit of a coin to release the latch bar to free the cart for being wheeled away by the user, and holding the coin until the user brings the cart back to a cart parking station, nests it in the end cart at the parking station, and inserts the latch bar which is tethered to said end cart in the mechanism to lock the returned cart to the series and to provide for return of the user's coin.

Steering gear

Friction let-off mechanism for looms.