18-02-2009 дата публикации
Номер: EP2025674A1
Substituted benzene compounds (I) and their salts, are new. Substituted benzene compounds of formula (I) and their salts, are new. Either R 1>, R 2>H, (1-8C)-alkyl, (1-4C)-alkoxy-(1-4C)-alkyl, (3-8C)-alkenyl, (3-8C)-alkynyl, CO(R 9>), (C(R 1> 0>)(R 1> 1>)) q-R 1> 2>, CO(C(R 1> 3>)(R 1> 4>)) rR 1> 5>, COO(1-8C)-alkyl or CO(C(R 1> 3>)(R 1> 4>)) rN(R 1> 6>)(R 1> 7>); and L 1>C(R 3> 4>)(R 3> 5>), C(R 3> 6>)(R 3> 7>)C(R 3> 8>)(R 3> 9>) or (3-6C)-cycloalkyl; and R 3> 4>-R 3> 9>H or (1-8C)-alkyl; or R 1>R 2>N : 4-10-membered mono-, bi- or spiro-cyclic ring (which additionally contains 0-3 heteroatoms except N, preferably O, N or S), where the heterocyclic ring system is additionally substituted by F, Cl, Br, CF 3, CN, (1-6C)-alkyl, (3-8C)-cycloalkyl, O-(1-8C)-alkyl, (1-4C)-alkoxy-(1-4C)-alkyl, hydroxy-(1-6C)-alkyl, oxo, CO(R 1> 8>), CON(R 1> 9>)(R 2> 0>), OH, COO(R 2> 1>), N(R 2> 2>)CO(1-6C)-alkyl, N(R 2> 3>)(R 2> 4>) or SO 2(1-6C)-alkyl; or R 1>R 3> 4>, R 1>R 3> 5>, R 1>R 3> 6>, R 1>R 3> 7>, R 1>R 3> 8>, R 1>R 3> 9>5-6-membered ring; R 1> 0>, R 1> 1>H, (1-6C)-alkyl, hydroxy-(1-2C)-alkyl, F or OH; either R 9>, R 1> 3>, R 1> 4>, R 1> 6>, R 1> 7>-R 2> 4>H or (1-6C)-alkyl; or R 1> 6>R 1> 7>N, R 2> 3>R 2> 4>N : 5-6 membered ring, which can include further 0-1 heteroatoms except N, which are NH, N-(1-6C)-alkyl, O or S; q, r : 0-6; R 1> 2>, R 1> 5>H, OH, F, O-(1-6C)-alkyl, S-(1-6C)-alkyl, O-phenyl, CN, COO(R 2> 5>), N(R 2> 6>)CO(1-6C)-alkyl, N(R 2> 7>)(R 2> 8>), CON(R 2> 9>)(R 3> 0>), SO 2(1-6C)-alkyl, 3-12-membered mono-, bi- or spiro-cyclic ring (containing 4 heteroatoms of N, O or S, and further substituted by F, Cl, Br, OH, CF 3, NO 2, CN, ...
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