Device of distribution of a fiberoptic plurality.

The invention relates to a mirror comprising a glass sheet and a silver layer applied to the glass and provided on its back with a protective coating comprising a layer of dried and crosslinked paint of the alkyd type and a layer of dried and crosslinked paint of the polyurethane type, the alkyd layer being located between the silver layer and the polyurethane layer. The invention also relates to its use for deflecting solar light onto a heat collector. The invention also relates to a process for manufacturing a mirror comprising: a silver layer is deposited on a glass sheet using a silverplating solution; then a layer of alkyd paint having a viscosity of between 25 and 110 seconds measured using a Ford No. 4 cup is applied on the side with the silver layer; then the alkyd paint layer is dried and crosslinked; then a layer of polyurethane paint having a viscosity of between 25 and 110 seconds measured using a Ford No. 4 cup is applied on the side with the alkyd layer; and then the polyurethane paint layer is dried and crosslinked.

MIRROR BENDS BY PRESSING

MIRROR BENDS BY PRESSING

L'invention concerne un procédé de fabrication d'un miroir bombé comprenant une feuille de verre, comprenant le bombage de la feuille par pressage contre une forme pleine puis l'application d'une couche d'argent sur ladite feuille. Le miroir est particulièrement adapté en tant que miroir solaire. Le miroir ainsi fabriqué est particulièrement adapté pour capter l'énergie solaire en le plaçant en extérieur pour le faire renvoyer la lumière solaire vers un collecteur de chaleur. The invention relates to a method of manufacturing a curved mirror comprising a glass sheet, comprising bending the sheet by pressing against a solid form and then applying a layer of silver on said sheet. The mirror is particularly suitable as a solar mirror. The mirror thus manufactured is particularly suitable for capturing solar energy by placing it outside to send back sunlight to a heat collector.

Orally administered bacteria as vehicles for systematic delivery of agents

The current invention relates to the use of a bacterial species in the preparation of a composition adapted for oral administration for the delivery of an agent to a site in the body. The site in the body may be an organ or a tumour site. The bacterial species is a food grade, non-pathogenic, gram-positive bacteria capable of anaerobic growth.

PROCESS FOR PREPARING 5-FLUORO-1H-PYRAZOLO [3,4-B] PYRIDIN-3-AMINE AND DERIVATIVES THEREOF

The present invention relates to a process for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine in high yield and purity. The present invention also relates to processes for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives. These processes are useful for preparing biologically active compounds, particularly certain GSK-3 inhibitors, or derivatives thereof. 4. The process of claim 3 , further comprising the step of cyclizing a compound of formula 4 with HNNH.HO under suitable cyclization conditions to form the compound of formula 5.54. The process of any one of - claims 1 , wherein the de-chlorination conditions comprise adding a palladium catalyst claims 1 , a suitable base claims 1 , and a suitable acid.6. The process of claim 5 , wherein said palladium catalyst is selected from Pd(OAc)or PPh claim 5 , said base is EtN claim 5 , and said acid is formic acid.7. The process of claim 5 , wherein said de-chlorination reduction is done at a temperature below 60° C.8. The process of claim 7 , wherein said de-chlorination reaction is done at a temperature of about 50° C.9. The process of claim 8 , wherein the de-chlorination reaction is done in DMF.10. The process of claim 9 , wherein the reaction is cooled to about 0° C. upon completion and mixed with water.11. The process of claim 10 , wherein said mixture is filtered through celite.12. The process of claim 5 , wherein the amide formation condition comprises the following two steps:(a) formation of an acid chloride from the carboxylic acid of formula 2;(b) reaction of the acid chloride with ammonia.13. The process of claim 12 , wherein the carboxylic acid is combined with a chlorinating agent selected from oxalyl chloride or thionyl chloride in the presence of DMF or DCM.14. The process of claim 12 , wherein ammonia is bubbled into a solution of the acid chloride in an aprotic solvent.15. The process of claim 3 , wherein the reduction conditions comprise adding TFAA dropwise to a cooled ...

SHOULDER IMPLANT DEVICE AND METHOD

An apparatus comprises a head, a neck, and a stem. The head is shaped to be insertable into an interval. The interval is formed using a reamed upper glenoid, a coracoid, and an acromion. The neck is in communication with the head. The neck is dimensioned to seat the head in the interval formed by the reamed upper glenoid, the coracoid, and the acromion. The stem is in communication with the neck. The stem is shaped to be insertable into a humerus. 1. An apparatus comprising:(a) a hemispherical head, wherein the head is shaped to be insertable in an interval formed by a reamed upper glenoid, a coracoid, and an acromion;(b) a neck in communication with the head, wherein the neck is dimensioned to seat the head in the interval formed by the reamed upper glenoid, the coracoid, and the acromion; and(c) a stem in communication with the neck, wherein the stem is shaped to be insertable into a humerus.2. The apparatus of claim 1 , wherein the diameter of the head comprises a width between 38 mm and 52 mm.3. The apparatus of claim 1 , wherein the length of the neck comprises a length between 5 mm and 60 mm.4. The apparatus of claim 1 , wherein the neck is in communication with the stem through a morse taper.5. A method of replacing a shoulder of a patient with an implantable device claim 1 , the implantable device comprising a head claim 1 , neck claim 1 , and stem claim 1 , the method comprising:(a) accessing a first interval formed by the upper glenoid, the coracoid, and the acromion of the patient;(b) reaming at least a portion of the upper glenoid;(c) forming a second interval with the reamed upper glenoid, the coracoid, and the acromion, wherein the second interval is recessed more deeply into the shoulder region of the patient than the first interval; and(d) seating the head within the second interval.6. The method of claim 5 , further comprising determining whether the head is seated sufficiently deep within the second interval.7. The method of claim 5 , further ...

LACTOBACILLUS PLANTARUM SPECIES POSSESSING BROAD SPECTRUM ANTI-FUNGAL ACTIVITY AND EXHIBITING HIGH HEAT TOLERANCE AND OSMOTOLERANCE

Isolated strains of are described that have anti-fungal activity against fungal spore suspensions, and specifically anti-fungal activity in fruit juices and fermented dairy products. The two species have also been found to have a high degree of heat tolerance and osmotolerance, and to have a high freeze-drying survival rate. 2. A bacterial culture of claim 1 , or a fermentation broth or supernatant thereof claim 1 , or an extract of the broth claim 1 , supernatant or bacterial culture claim 1 , for use as an anti-fungal agent.3. A bacterial culture of claim 1 , or a fermentation broth or supernatant thereof claim 1 , or an extract of the broth claim 1 , supernatant or bacterial culture claim 1 , for use as a preservative in a food product prone to spoilage.4. A bacterial culture of claim 1 , or a fermentation broth or supernatant thereof claim 1 , or an extract of the broth claim 1 , supernatant or bacterial culture claim 1 , for use as a preservative in a fruit-based food product.5. A bacterial culture of claim 1 , or a fermentation broth or supernatant thereof claim 1 , or an extract of the broth claim 1 , supernatant or bacterial culture claim 1 , for use as a preservative in a fruit juice.6. A bacterial culture of claim 1 , or a fermentation broth or supernatant thereof claim 1 , or an extract of the broth claim 1 , supernatant or bacterial culture claim 1 , for use as a preservative in a dairy product.7. A bacterial culture of for use in a starter culture for a fermented dairy product.8. A bacterial culture of claim 1 , or a fermentation broth or supernatant thereof claim 1 , or an extract of the broth claim 1 , supernatant or bacterial culture claim 1 , for use as a medicament.9. A method for extending the shelf-life of a food product comprising the step of incorporating an isolated bacterial culture of claim 1 , or a fermentation broth or supernatant thereof claim 1 , or an extract of the broth claim 1 , supernatant or bacterial culture claim 1 , into the ...

Precision ribbon resistance welding system

Disclosed herein is a resistance welding system for welding a ribbon to a bond site of a bond surface. The system includes a welding header, a bond header, a ribbon dispenser, a cutter, and a support surface. The welding header includes a resistance welding tip. The bond header includes a bond foot displaceable relative to the bond surface. The bond foot includes a welding aperture. The ribbon dispenser feeds the ribbon to the bond foot. The support surface is configured to support the bond surface. The bond foot is configured to press the ribbon against the bond site of the bond surface, which is thereby forced against the support surface. With the ribbon so pressed against the bond site, the system is configured to cause the welding tip to enter the welding aperture to resistance weld the ribbon to the bond site of the bond surface.

INHIBITORS OF VAP-1

Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity. 10. The compound of any one of - , or an alkene isomer , tautomer , or an isotopic variant thereof; or a pharmaceutically acceptable salt , solvate , hydrate , or prodrug thereof , wherein Xis ═N—.11. The compound of any one of - , or an alkene isomer , tautomer , or an isotopic variant thereof; or a pharmaceutically acceptable salt , solvate , hydrate , or prodrug thereof , wherein Xis ═CH—.12. The compound of any one of - , or an alkene isomer , tautomer , or an isotopic variant thereof; or a pharmaceutically acceptable salt , solvate , hydrate , or prodrug thereof , wherein Xis ═N—.13. The compound of any one of - , or an alkene isomer , tautomer , or an isotopic variant thereof; or a pharmaceutically acceptable salt , solvate , hydrate , or prodrug thereof , wherein Xis ═CH—.18. The compound of any one of - , or an alkene isomer , tautomer , or an isotopic variant thereof; or a pharmaceutically acceptable salt , solvate , hydrate , or prodrug thereof , wherein Y is a bond.19. The compound of any one of - , or an alkene isomer , tautomer , or an isotopic variant thereof; or a pharmaceutically acceptable salt , solvate , hydrate , or prodrug thereof , wherein Y is —OCF—.20. The compound of any one of - , or an alkene isomer , tautomer , or an isotopic variant thereof; or a pharmaceutically acceptable salt , solvate , hydrate , or prodrug thereof , wherein Y is —O—.21. The compound of any one of - , or an alkene isomer , tautomer , or an isotopic variant thereof; or a pharmaceutically acceptable salt , solvate , hydrate , or prodrug thereof , wherein Y is —S—.22. The compound of any one of - , or an alkene isomer , tautomer , or an isotopic variant thereof; or a pharmaceutically acceptable salt , solvate , hydrate , or prodrug thereof , wherein Y is —NH—.23. The compound of any one of - , or an alkene isomer , tautomer , or an isotopic variant thereof; or a ...

METHODS AND KITS TO DETERMINE THE SENSITIVITY OF STRAINS OF LACTOCOCCUS LACTIS BACTERIA TO PHAGE INFECTION

A kit useful for determining the phage susceptibility of one or more strains of is described. The disclosure also describes methods for formulation of mixed defined starter cultures using strains from different phage sensitivity groups.

Bifidobacterium Longum

The multiple embodiments described herein comprise the genome of a probiotic bifidobacteria strain and genes encoded by the genome. Various novel are described. 1Bifidobacterium longum. A pharmaceutical ingestable carrier comprising more than 10CFU per gram of the ingestible carrier of an isolated strain of AH121A deposited at NCIMB with accession number NCIMB 41675 , wherein the pharmaceutical ingestable carrier is a tablet , and wherein the strain induces a ratio of interleukin-10 to interleukin-12 of at least 10 in a peripheral blood mononuclear cell co-incubation assay.2. A method of improving gastrointestinal health in a subject claim 1 , the method comprising administering a composition comprising a therapeutically effective amount of the pharmaceutical ingestable carrier of .3. A method for providing a probiotic to a subject claim 1 , the method comprising administering a composition comprising a therapeutically effective amount of the pharmaceutical ingestable carrier of .4Bifidobacterium longumBifidobacterium longum. An ingestible carrier comprising a freeze dried powder comprising more than 10CFU per gram of the ingestible carrier of a viable isolated and purified strain claim 1 , excluding strain 35624 (NCIMB 41003) claim 1 , wherein the strain:a) expresses an exopolysaccharide; andb) comprises nucleic acid sequences of SEQ ID NO. 96 and SEQ ID NO. 97;wherein the ingestible carrier is a tablet;wherein the strain induces a ratio of interleukin-10 to interleukin-12 of at least 10 in a peripheral blood mononuclear cell co-incubation assay.5. The ingestible carrier of claim 4 , wherein the strain does not comprise the nucleic acid sequence of SEQ ID No. 112.6. The ingestible carrier of claim 4 , wherein the strain comprises two nucleic acid sequences selected from the group consisting of SEQ ID No. 114 to SEQ ID No. 132 and nucleic acid sequences with at least 95% sequence homology thereto.7. The ingestible carrier of claim 6 , wherein the two nucleic acid ...

METHOD FOR HIGH SPEED STRANDING OF ARAMID YARNS

A method for stranding aramid yarn around an endless core includes a stranding step that involves a stranding apparatus having at least one yarn bobbin. The bobbin revolves around its own axis and the bobbin revolves around the core, wherein the yarn unwinds from the bobbin and winds around the core. The yarn is a continuous aramid yarn provided with 0.05 to 0.95 wt %, based on the weight of the aramid, of a finish including an organophosphorus compound. The organophosphorus compound is a compound of the formula X1X2X3P═O. X1, X2, and X3 are independently selected from Y1-, Y1-O—, and M-O. Y1 is a branched or straight-chain C1-C20 alkyl, aryl or alkenyl. M is selected from Li, Na, K, or ammonium. At least one of X1, X2, or X3 is selected from Y1- or Y1-O—. 1. A method for stranding aramid yarn around an endless core , comprising:providing the endless core to a stranding apparatus comprising at least one yarn bobbin,wherein the bobbin revolves around its own axis and the bobbin revolves around the core during operation of the stranding apparatus; andstranding the yarn around the core by unwinding the yarn from the bobbin and surrounding the core with the yarn, whereinthe yarn is a continuous aramid yarn provided with 0.05 to 0.95 wt %, based on the weight of the aramid, of a finish comprising an organophosphorus compound;the organophosphorus compound is a compound of the formula X1X2X3P═O;X1, X2, and X3 are independently selected from the group consisting of Y1-, Y1-O—, and M-O;Y1 is a branched or straight-chain C1-C20 alkyl, aryl or alkenyl;M is Li, Na, K, or ammonium; andat least one of X1, X2, or X3 is Y1- or Y1-O—, and the different types of Y1 are the same or different.2. The method according to claim 1 , wherein the continuous aramid yarn is provided with 0.10 to 0.50 wt % of the finish.5. The method according to claim 4 , wherein:R1 is a branched or straight-chain C4-C12 alkyl, andR2 is H, Li, Na, K or NH4 or a branched or straight-chain C4-C12 alkyl.6. The ...

METHOD AND APPARATUS FOR MULTI-CORE PROCESSOR MANAGEMENT IN A MOTION CONTROL SYSTEM

According to techniques disclosed herein, a motion control program for execution on a multi-core processor of a motion control system includes multiple task types or task classes, with different ones of the task types divided among the respective processing cores of the multi-core processor. For example, the division depends on user input or on assessing the expected or measured performance of the involved motion control program. Assigning a type or class of tasks to a respective processing core results in a mapping the lower-level executable instructions that represent the type or class of task to a target one of the processing cores. However, dividing the task types or classes among the processing cores at the abstraction level of the motion control program advantageously provides for tailoring the processing-core assignments to the characteristics or needs of the motion-control problem embodied in the motion control program. 1. A method performed by a computer system , the method comprising:determining a division of task types among processing cores of a multicore processor in a motion control system, the task types being different types of program tasks in a motion control program targeted for execution by the motion control system and the division assigning two or more task types to respective processing cores of the multicore processor;generating a configuration file embodying the division of task types; andsaving the configuration file in a memory or storage device, for processing by the motion control system that implements the motion control program.2. The method of claim 1 , wherein determining the division of task type comprises receiving user input indicating a user-selected strategy for core management claim 1 , from among a plurality of selectable strategies for core management claim 1 , each selectable strategy for core management defining a respective distribution of the task types among the processing cores of the multicore processor.3. The method ...

PROCESS FOR THE DIFFERENTIAL SOLUBILITY-DRIVEN ASYMMETRIC TRANSFORMATION OF SUBSTITUTED 2H-CHROMENE-3-CARBOXYLIC ACIDS

This invention relates to a method for preparing a desired isomer of a substituted 2-trifluoromethyl-2H-chromene-3-carboxylic acid, which is characterized by comprising: (a) contacting the substituted 2-trifluoromethyl-2H-chromene-3-carboxylic acid with a chiral amine to form salts, wherein the chiral amine is selected so that the solubility of the amine salt of the undesired substituted 2-trifluoromethyl-2H-chromene-3-carboxylic acid is greater than the amine salt of the desired substituted 2-trifluoromethyl-2H-chromene-3-carboxylic acid, and (b) irradiating the mixture with an ultraviolet (UV) light, wherein the irradiation increases the amount of the less soluble chiral amine salt of the substituted of the 2-trifluoromethyl-2H-chromene-3-carboxylic acid in the mixture. 122-. (canceled)23. A method for preparing a desired isomer of a substituted 2-trifluoromethyl-2H-chromene-3-carboxylic acid , comprising:(a) in a solvent or mixture of solvents, contacting the substituted 2-trifluoromethyl-2H-chromene-3-carboxylic acid with a chiral amine to form salts, wherein the chiral amine is selected so that the solubility of the amine salt of the undesired substituted 2-trifluoromethyl-2H-chromene-3-carboxylic acid is greater than the amine salt of the desired substituted 2-trifluoromethyl-2H-chromene-3-carboxylic acid, and(b) irradiating the mixture with an ultraviolet (UV) light, wherein the irradiation increases the amount of the less soluble chiral amine salt of the substituted of the 2-trifluoromethyl-2H-chromene-3-carboxylic acid in the mixture,wherein the chiral amine is selected from the group consisting of: (S)-N-Benzyl-alpha-methylbenzylamine, (1R,2R)-2-Amino-1-phenyl-1,3-propanediol, (R)-1-(1-Naphthyl)ethylamine, (S)-2-Amino-3-phenyl-1-propanol, and L-Phenylalaninamide, and{'sub': 5', '10', '1', '6', '2', '8', '2', '8', '3', '8, 'wherein the solvent is selected from the group consisting of: C-Caliphatic hydrocarbons, aromatic hydrocarbons, C-Calcohols, C-Cethers, ...

PHAGE RESISTANT LACTIC ACID BACTERIA

The present invention provides a method for the construction of a bacteriophage-insensitive mutant of a Streptococcus thermophilus parent strain whereby the bacteriophage insensitivity is not based on the CRISPR resistance mechanism but based on another mechanism. The method provides a protocol by which this can be achieved by inactivating one or more of the CRISPR systems present in a given strain. The invention also provides the bacteriophage-insensitive mutants as well as their use in a process for making a dairy product. 1Streptococcus thermophilus. A method for the isolation of bacteriophage-insensitive mutants from a parent strain comprising:a. inactivating the CRISPR resistance mechanism of the parent strain;b. exposing the parent strain obtained in step a) to a bacteriophage;c. isolating bacteriophage insensitive mutants;d. comparing the CRISPR loci of the parent strain with the CRISPR loci of the bacteriophage insensitive mutants; ande. selecting bacteriophage-insensitive mutants of which the CRISPR loci is identical to the CRISPR loci of the parent strain.2. A method according to claim 1 , comprising claim 1 , exposing the parent strain obtained in a) to a single type of bacteriophage.3. A method according to claim 1 , wherein the CRISPR resistance mechanism is inactivated by a method selected from the group consisting of:a. introducing into the parent strain one or more DNA constructs comprising a promoter followed by one or more cas genes or a part thereof or a nucleotide sequence at least 90% identical to the cas gene in the reverse orientation such that the cas gene is transcribed into the corresponding antisense RNA which subsequently binds to the target cas mRNA thereby silencing the cas gene;{'i': 'Streptococcus thermophilus', 'b. introducing into the parent strain one or more DNA constructs comprising a catalytically inactive Cas9 protein and one or more guide RNAs (sgRNAs) for transcriptional repression of the one or more cas gene(s) in the parent ...

PHAGE INSENSITIVE STREPTOCOCCUS THERMOPHILUS

Bacteriophage Insensitive Mutants (BIMs) of three parent strains were generated and characterized for phage sensitivity, sedimentation rate, cell chain length, phage adsorption and CRISPR loci alterations. Several BIMs showed an altered sedimentation phenotype as well as an increase cell chain length, reduced phage sensitivity, reduced phage adsorption and 100% identity in three CRISPR loci. The results show that the derived BIMs have become phage-resistant through a mechanism other than CRISPR. 1. A method for the construction of a bacteriophage insensitive mutant of a microorganism parent strain suitable for food and feed fermentation comprising selecting one or more mutants which , compared to parent strain , has an increased sedimentation rate and/or an increased chain formation to provide the bacteriophage insensitive mutant.2. A method according to claim 1 , comprising:a. exposing the parent strain to a bacteriophage;b. optionally isolating single colonies of the bacteriophage insensitive mutant; 1. an increased sedimentation rate and/or', '2. an increased chain formation; and, 'c. selecting one or more bacteriophage insensitive mutants which, compared to parent strain suitable for food and feed fermentation, hasd. optionally isolating single colonies of the bacteriophage insensitive mutant.3Streptococcus thermophilusStreptococcus thermophilus.. Method according to claim 1 , wherein the microorganism parent strain suitable for food and feed fermentation is a lactic acid bacterium claim 1 , optionally a optionally a bacteriophage sensitive4Streptococcus thermophilusStreptococcus thermophilus. A method according to claim 3 , wherein the one or more bacteriophage insensitive mutants which claim 3 , compared to parent strain claim 3 , has an increased sedimentation rate and/or an increased chain formation is further subjected to comparing CRISPR loci of the bacteriophage sensitive parent strain with CRISPR loci of the bacteriophage insensitive mutant and selecting ...

Method and system for damping vibrations in a tool string system

The invention provides a control system and method for limiting vibrations in a tool string system. The system comprises a pump connected to a rotatable tool string driven by a drive system. The control system comprises feedback of both torque and rotational speed signals into a controller. An objective of said controller is to maintain the drive speed over torque ratio equal to the connected tool string impedance (Z). A secondary objective, for lower frequencies, is to approach and maintain a setpoint speed as drive rotation speed. The system includes a rotational speed sensor and a torque sensor, with the latter optionally replaced by a motor torque signal already available from a variable frequency drive (VFD) for an AC motor and the current safeguarding signal for a DC motor.

Genetic Transformation of Bifidobacteria

The present invention concerns a method for genetically transforming a strain comprising a step of methylation of a shuttle vector in an or a Gram-positive bacterium strain by two type II DNA methyltransferases from a a methyltransferase enzyme that methylates the adenine base at position 4 of the nucleotide sequence RTCAGG and a methyltransferase enzyme that methylates the cytosine base at position 4 of the nucleotide sequence GGWCC. The present invention also concerns genetic tools and culture media useful for carrying out said method. 1Bifidobacterium. A method for genetically transforming a strain , the method comprising:{'i': Escherichia coli', 'Bifidobacterium', 'Bifidobacterium', 'Bifidobacterium', 'Bifidobacterium,', 'E. coli, 'i) transforming an strain or a Gram-positive bacterium strain either with a recombinant vector DNA comprising a gene encoding a methyltransferase enzyme from a that methylates the adenine base at position 4 of the nucleotide sequence RTCAGG (BanLI methyltransferase) and a recombinant vector DNA comprising a gene encoding a methyltransferase enzyme from a that methylates the cytosine base at position 4 of the nucleotide sequence GGWCC (BanLII methyltransferase), or with a recombinant vector DNA comprising both a gene encoding a BanLI methyltransferase from a and a gene encoding a BanLII methyltransferase from a wherein said recombinant vectors DNA are capable of replicating in said or Gram-positive bacterium strain,'}{'i': E. coli', 'Bifidobacterium', 'E. coli', 'Bifidobacterium, 'ii) transforming the or Gram-positive bacterium strain of step i) with a recombinant shuttle vector DNA comprising a DNA sequence of interest to introduce in a strain, wherein the said shuttle vector DNA is capable of replicating in the or the Gram-positive bacteria strain of step i) and in the strain to be targeted for genetic transformation,'}{'i': 'E. coli', 'iii) cultivating the transformed or Gram-positive bacterium strain obtained in step ii),'}{'i': 'E ...

PHAGE INSENSITIVE STREPTOCOCCUS THERMOPHILUS

Bacteriophage Insensitive Mutants (BIMs) of three parent strains were generated and characterized for phage sensitivity, sedimentation rate, cell chain length, phage adsorption and CRISPR loci alterations. Several BIMs showed an altered sedimentation phenotype as well as an increase cell chain length, reduced phage sensitivity, reduced phage adsorption and 100% identity in three CRISPR loci. The results show that the derived BIMs have become phage-resistant through a mechanism other than CRISPR. 1. A method for the construction of a bacteriophage insensitive mutant of a microorganism parent strain suitable for food and feed fermentation comprising selecting one or more mutants which , compared to parent strain , has an increased sedimentation rate and/or an increased chain formation to provide the bacteriophage insensitive mutant.2. The method according to claim 1 , comprising the steps of:a. exposing the parent strain to a bacteriophage;b. optionally isolating single colonies of the bacteriophage insensitive mutant; 1. an increased sedimentation rate and/or', '2. an increased chain formation; and, 'c. selecting one or more bacteriophage insensitive mutants which, compared to parent strain suitable for food and feed fermentation, hasd. optionally isolating single colonies of the bacteriophage insensitive mutant.3Streptococcus thermophilusStreptococcus thermophilus.. The method according to claim 1 , wherein the microorganism parent strain suitable for food and feed fermentation is a lactic acid bacterium claim 1 , preferably a more preferably a bacteriophage sensitive4Streptococcus thermophilusStreptococcus thermophilus. The method according to claim 3 , wherein the one or more bacteriophage insensitive mutants which claim 3 , compared to parent strain claim 3 , has an increased sedimentation rate and/or an increased chain formation is further subjected to comparing CRISPR loci of the bacteriophage sensitive parent strain with CRISPR loci of the bacteriophage ...

BACTERIOPHAGE DETECTION

The present invention relates to a kit suitable for detection of infecting phages, said kit comprising: (a) a first primer pair suitable to generate an amplicon characteristic for a 987 phage; and (b) a second primer pair suitable to generate an amplicon characteristic for a 5093 phage. Further, the present invention relates to a method for detecting the presence of infecting phages in a sample. 1Streptococcus thermophilus. A kit suitable for detection of infecting phages , said kit comprising:(a) a first primer pair suitable to generate an amplicon characteristic for a 987 phage; and(b) a second primer pair suitable to generate an amplicon characteristic for a 5093 phage.2. Kit according to claim 1 , further comprising:(a) a third primer pair suitable to generate an amplicon characteristic for a cos phage; and/or(b) a fourth primer pair suitable to generate an amplicon characteristic for a pac phage.3. Kit according to claim 1 , wherein the first primer pair comprises a forward primer according to SEQUENCE ID NO: 1 and a reverse primer according to SEQUENCE ID NO: 2 claim 1 , wherein the second primer pair comprises a forward primer according to SEQUENCE ID NO: 3 and a reverse primer according to SEQUENCE ID NO: 4.4. Kit according to claim 2 , wherein the third primer pair comprises a forward primer according to SEQUENCE ID NO: 5 and a reverse primer according to SEQUENCE ID NO: 6 claim 2 , wherein the fourth primer pair comprises a forward primer according to SEQUENCE ID NO: 7 and a reverse primer according to SEQUENCE ID NO: 8.5. Kit according to claim 1 , wherein the kit is suitable for detection of four distinct phage groups claim 1 , optionally chosen from 987 phages claim 1 , 5093 phages claim 1 , cos containing phages and pac containing phages.6Streptococcus thermophilus. Method for detecting the presence of infecting phages in a sample claim 1 , comprising:(i) providing a sample;(ii) performing a PCR analysis of the sample using a first primer pair suitable ...

METHODS FOR INCREASING PROLIFERATION OF MAMMALIAN CELLS

The invention describes peptide, and proteins and fusion proteins comprising the peptides, that are capable of increasing the proliferation of cells, especially epithelial cells in the mammalian gastrointestinal tract. The peptides comprise the hydrophilic domain of the TadE subunit of the Tad pilus of Bifidobacterium, especially the pilus encoded by the Tad2003 gene cluster identified in Bifidobacterium breve UCC2003, and functional fragments of the hydrophilic domain. The invention informs new treatments for diseases and conditions that involve attenuated epithelial cell proliferation and growth, such as inflammatory conditions of the gastrointestinal tract and trauma of the skin including burns and other wounds. The invention also informs treatments of newborn babies to promote proliferation and growth of gut epithelial tissue by administration of agents comprising the peptide of the invention in the form of infant formula. 1. An isolated TadE polyamino acid sequence , for use as a medicament.2. An isolated TadE polyamino acid sequence , for use in a method of inducing proliferation of epithelial cells in a subject having epithelial cells damaged by disease , surgery , trauma , chemotherapy or radiotherapy.3. An isolated TadE polyamino acid sequence , for use in a method of development of gut epithelial lining in a premature infant.4. An isolated TadE polyamino acid sequence , for use in a method of treating or preventing a disease or condition in a subject characterised by attenuated cellular growth of a target tissue.5. An isolated TadE polyamino acid sequence claim 4 , for use of claim 4 , in which the disease is an inflammatory disease of the gastrointestinal tract.6. An isolated TadE polyamino acid sequence claim 4 , for use of any of to claim 4 , in which the polyamino acid sequence comprises SEQUENCE ID NO: 30.7. An isolated TadE polyamino acid sequence claim 4 , for use of any of to claim 4 , in which the polyamino acid sequence comprises SEQUENCE ID NO: ...

ORALLY ADMINISTERED BACTERIA AS VEHICLES FOR SYSTEMIC DELIVERY OF AGENTS

The current invention relates to the use of a bacterial species in the preparation of a composition adapted for oral administration for the delivery of an agent to a site in the body. The site in the body may be an organ or a tumour site. The bacterial species is a food grade, non-pathogenic, gram-positive bacteria capable of anaerobic growth. 1. A method of delivering an agent to an extra-intestinal site in the body , the method comprising:orally administering a composition to the subject, the composition comprising at least one bacterial species adapted for oral administration, the bacterial species being one of linked to the agent and capable of expressing the agent,wherein the bacterial species targets a site in the body and the agent is delivered one of within and adjacent to the site in the body.2. The method of claim 1 , wherein the site is one of an organ of the body claim 1 , a tumour site claim 1 , and the bloodstream.3. The method of claim 1 , wherein the bacterial species is a food grade claim 1 , non-pathogenic claim 1 , gram-positive bacteria capable of anaerobic growth.4E. coli, Bifidobacteria, LactobacillusLactococcus. The method of claim 3 , wherein the food grade claim 3 , non-pathogenic claim 3 , gram-positive bacteria capable of anaerobic growth is an or a species.5. The method of claim 1 , wherein the bacterial species is viable.6. The method of claim 1 , wherein the agent is encoded on a vector capable of expressing at least one gene claim 1 , the vector being transformed into the bacterial species.7. The method of claim 1 , wherein the agent is linked to the bacterial species.8. The method of claim 1 , wherein the agent is selected from the group comprising:an imaging agent, such as a fluorescent protein (e.g. RFP, GFP) a substrate-converting enzyme (e.g., Luciferase, bacterial lux operon, Alkaline Phosphatase, B-Galactosidase), or image contrast-enhancing agent, a tumour suppressing agent, such as an anti-angiogenic agent (e.g. endostatin, ...

STREPTOCOCCUS THERMOPHILUS STARTER CULTURES

The present invention relates to a starter culture comprising at least two strains, wherein a first and a second strain are chosen from RGP group 1, RGP group 2, RGP group 3 and RGP group 4, with the proviso that the first and second strains do not belong to the same RGP group. 1Streptococcus thermophilusStreptococcus thermophilusStreptococcus thermophilus. A starter culture comprising at least two strains , wherein a first and a second strain are chosen from RGP group 1 , RGP group 2 , RGP group 3 and RGP group 4 , with the proviso that the first and second strains do not belong to the same RGP group;{'i': 'Streptococcus thermophilus', 'wherein RGP group 1 is defined as the group of strains which allow to generate an amplicon by using a primer pair according to SEQ ID NO 1 and SEQ ID NO 2 in a PCR reaction;'}{'i': 'Streptococcus thermophilus', 'wherein RGP group 2 is defined as the group of strains which allow to generate an amplicon by using a primer pair according to SEQ ID NO 4 and SEQ ID NO 5 in a PCR reaction;'}{'i': 'Streptococcus thermophilus', 'wherein RGP group 3 is defined as the group of strains which allow to generate an amplicon by using a primer pair according to SEQ ID NO 7 and SEQ ID NO 8 in a PCR reaction;'}{'i': 'Streptococcus thermophilus', 'wherein RGP group 4 is defined as the group of strains which allow to generate an amplicon by using a primer pair according to SEQ ID NO 10 and SEQ ID NO 11 in a PCR reaction.'}2Streptococcus thermophilusStreptococcus thermophilus. The starter culture according to claim 1 , further comprising a third strain chosen from RGP group 1 claim 1 , RGP group 2 claim 1 , RGP group 3 and RGP group 4 claim 1 , with the proviso that that the first claim 1 , second and third strain do not belong to the same RGP group.3Streptococcus thermophilusStreptococcus thermophilus. The starter culture according to claim 1 , further comprising a fourth strain chosen from RGP group 1 claim 1 , RGP group 2 claim 1 , RGP group 3 and RGP ...

BIFIDOBACTERIUM LONGUM

The multiple embodiments described herein comprise the genome of a probiotic bifidobacteria strain and genes encoded by the genome. Various novel are described. 18-. (canceled)9Bifidobacterium longum. A formulation comprising an ingestible carrier and a viable isolated and purified strain in the form of a powder , wherein the formulation comprises more than 10cfu of the strain per gram of the formulation , expresses an exopolysaccharide; and', 'comprises nucleic acid sequences of SEQ ID NO. 96 and SEQ ID NO. 97; and, 'wherein the strain{'i': Bifidobacterium longum', 'Bifidobacterium longum', 'Bifidobacterium longum, 'wherein the strain is not 35624 deposited under accession number NCIMB 41003, AH121A deposited under accession number NCIMB 41675, or BL1207 deposited under accession number ATCC PTA-9608.'}10. The formulation of claim 9 , wherein the strain induces a ratio of interleukin-10 to interleukin-12 of at least 10 in a peripheral blood mononuclear cell co-incubation assay.11. The formulation of claim 9 , wherein the strain comprises SEQ ID No. 131 or a nucleic acid sequence with at least 95% sequence homology thereto claim 9 , and SEQ ID No. 132 or a nucleic acid sequence with at least 95% sequence homology thereto.12. The formulation of claim 9 , wherein the formulation is in the form of a tablet.13. The formulation of claim 9 , wherein the formulation is in the form of a food product or a beverage.14. The formulation of claim 13 , wherein the food product comprises acidified milk claim 13 , yoghurt claim 13 , frozen yoghurt claim 13 , milk powder claim 13 , milk concentrate claim 13 , a cheese spread claim 13 , or a dressing.15. The formulation of claim 9 , wherein the formulation comprises 1×10cfu of the strain per gram of the formulation.16Bifidobacterium longum. A formulation comprising an ingestible carrier and a viable isolated and purified strain claim 9 , wherein the formulation is in the form of a tablet claim 9 , expresses an exopolysaccharide; and ...

Foamed film comprising polyethylene foam

The invention is directed to foamed film comprising a polyethylene foam obtained by physically foaming of a low density polyethylene copolymer with a density between 910 kg/m 3 and 935 kg/m 3 (according to ISO 1183) and a melt index between 0.10 and 100 dg/minute (according to ASTM D1133) wherein the low density polyethylene is obtained by a high pressure polymerisation process of ethylene in the presence of a di- or higher functional monomer.

An engineered gram positive bacterium

A recombinant gram positive commensal bacterium engineered for heterologous expression of Tad pilus. The Tad pilus is a Tad pilus from a Bifidobacterium selected from Bifidobacterium breve and Bifidobacterium longum. The bacterium is additionally engineered for heterologous expression in-situ in the human gut of a soluble biopharmaceutical product such as a cytokine, an enzyme, a hormone, and an antibody or antibody fragment. The invention also provides a method of treating an inflammatory disease of the human gut comprising administering a recombinant gram positive commensal bacterium of the invention, whereby the recombinant bacterium colonises the patients gut and effects in-situ expression of a soluble biopharmaceutical product in the patient's gut.

Methods, systems, and media for modifying open space access using generative design

Method for modifying open space access using generative design is provided. The method comprises: receiving map data corresponding to a location; receiving, data from sensors positioned within the geographic location; determining a plurality of spaces within the location that are available for reservations, wherein each space is associated with an activity type and wherein the activity type is selected based on information associated with spaces that are proximal to each space and the data from the sensors positioned within the geographic location; causing a user interface for reserving one of the spaces within the location to be presented in connection with a map of the location that is generated based on the map data; receiving an indication that a space within the map of the location is to be reserved; and updating the user interface to indicate that the space within the map of the location has been reserved while concurrently placing a reservation for the space.

Through-drill string conveyed logging system

A system for drilling and logging of a wellbore formed in an earth formation is provided. The system comprises a logging tool string and a drill string having a longitudinal channel for circulation of drilling fluid, the drill string including a port providing fluid communication between the channel and the exterior of the drill string, the channel and the port being arranged to allow the logging tool string to pass through the channel and from the channel through the port to a position exterior of the drill string. The system further comprises a removable closure element adapted to selectively close the port, wherein the logging tool string may be selectively connected to the closure element.

Logging method

The invention relates to a method of operating a logging tool (15) in a wellbore formed in an earth formation, the wellbore having at least a section which is to be provided with a wellbore component (e.g. casing). The method comprises arranging the logging tool in a selected relationship relative to said component (9) so that the logging tool is guided by the component through the wellbore during lowering of the component into the wellbore, and lowering the component with the logging tool in said selected relationship through the wellbore to said section of the wellbore. The logging tool is operated so as to provide logging data of the earth formation surrounding the wellbore, the logging data are transferred to surface, and the logging tool is retrieved.

Phage insensitive Streptococcus thermophilus

Bacteriophage Insensitive Mutants (BIMs) of three

Bifidobacterium longum

The multiple embodiments described herein comprise the genome of a probiotic Bifidobacterium longum bifidobacteria strain and genes encoded by the genome. Various novel Bifidobacterium longum are described.

Wellstring assembly

A wellstring assembly comprising a tubular first wellstring part with a passageway; a second wellstring part co-~operating with the first wellstring part; and a releasable wellstring-interconnecting means for selectively interconnecting the first and second wellstring parts; an auxiliary tool for manipulating the second wellstring part, which auxiliary tool can pass along the passageway in the first wellstring part to the second wellstring part, comprising a tool-connecting means for selectively connecting the auxiliary tool to the second wellstring part, and an operating means for operating the wellstring-interconnecting means.

Drilling a borehole

A method of drilling a borehole into a subsurface earth formation, using a tubular drill string which includes at its lower end a bottom hole assembly comprising a drill bit, a drill steering system, and a surveying system, wherein the drill string includes a passageway for an auxiliary tool from a first position interior of the drill string above the bottom hole assembly to a second position wherein at least part of the auxiliary tool is exterior of the drill string below the bottom hole assembly, which passageway can be selectively closed, and which method comprises drilling so as to progress the drill string into the earth formation, until a tool operating condition is met; opening the passageway; passing an auxiliary tool from the first position through the passageway to the second position, and operating the auxiliary tool at the second position.

Drilling a borehole

A method of drilling a borehole into a subsurface earth formation, using a tubular drill string which includes at its lower end a bottom hole assembly comprising a drill bit, a drill steering system, and a surveying system. The drill string includes a selectively closable passageway for passing an auxiliary tool from a first position interior of the drill string above the bottom hole assembly to a second position. In the second position, at least part of the auxiliary tool is exterior of the drill string below the bottom hole assembly. The drill string is progressed into the earth formation by drilling. When a tool operating condition is met the passageway is opened and the auxiliary tool is passed through the passageway from the first position to the second position, where the auxiliary tool is operated.

Logging method

Through-drill string conveyed logging system

Combined logging and drilling system

A system is provided for drilling and logging of a wellbore formed in an earth formation. The system comprises a drill string provided with an external recess extending in longitudinal direction of the drill string, a fluid passage for flow of drilling fluid from an upper end of the drill string to a lower end thereof, and a port providing fluid communication between the fluid passage and the recess. The system further comprises a logging tool string capable of passing through the fluid passage and from the fluid passage via the port into the recess, and a removable closure element adapted to selectively close the port.

Bifidobacterium longum

The multiple embodiments described herein comprise the genome of a probiotic Bifidobacterium longum bifidobacteria strain and genes encoded by the genome. Various novel Bifidobacterium longum are described.

Water-free release/lubricating agents for treating the walls of a die for original shaping or reshaping

A water-free composition for treating the walls of a die for original shaping or reshaping contains up to 30% of a polyolefin and/or paraffin wax and at least 70% of oil, where the oil is a silicone oil, a synthetic oil, a vegetable oil, a mineral oil, or a blend of several such oils. To produce a water-free composition according to the invention, one or more waxes are mixed with the oil or oils and any additives desired until a homogeneous mixture is obtained. The water-free release/lubricating agents according to the invention are used especially to treat the walls of a die for shaping or reshaping.

Method for high speed stranding of aramid yarns

The invention pertains to a method for stranding aramid yarn around an endless core, wherein the core is provided for a stranding step to a stranding apparatus comprising at least one yarn bobbin, wherein during operation the bobbin revolves around its own axis and the bobbin revolves around the core, and unwinding the yarn from the bobbin around the core to provide a core surrounded by the yarn, wherein the yarn is a continuous aramid yarn provided with 0.05 to 0.95 wt%, based on the weight of the aramid, of a finish comprising an organophosphorus compound, wherein the organophosphorus compound is a compound of the formula X1X2X3P=O, wherein X1, X2, and X3 are independently selected from Y1-, Y1-O-, and M-O, wherein Y1 is a branched or straight-chain C1-C20 alkyl, aryl or alkenyl, with M being selected from Li, Na, K, or ammonium, with the proviso that at least one of X1, X2, or X3 is selected from Y1- or Y1-O-, wherein the different types of Y1 may be the same or different. In one embodiment, the continuous aramid yarn is provided with 0.10 to 0.50 wt% of the finish. It has been found that the use of a relatively minor amount of a finish comprising a specific organophosphorus compound results in an improved package stability on a rotating server with a rolling yarn take-off. Consequently, packages of aramid yarns provided with this finish allow for high speed stranding of aramid yarn around an endless core.

Tracer release method for monitoring fluid flow in a well

A tracer release method for monitoring fluid flow in a well utilizes a deformable container having a liquid tracer material which container has an outlet which debouches into the neck portion of a venturi in a well conduit. The container has a wall which is at least partly exposed to the fluid pressure at the relatively wide in- or outlet of the venturi, so that an amount of tracer is injected continuously or discontinuously into the well effluents which is proportional to the pressure difference p across the venturi, which pressure difference p is indicative of the fluid density ρ and squared fluid velocity υ.

Combined logging and drilling system

A system is provided for drilling and logging of a wellbore formed in an earth formation. The system comprises a drill string provided with an external recess extending in longitudinal direction of the drill string, a fluid passage for flow of drilling fluid from an upper end of the drill string to a lower end thereof, and a port providing fluid communication between the fluid passage and the recess. The system further comprises a logging tool string capable of passing through the fluid passage and from the fluid passage via the port into the recess, and a removable closure element adapted to selectively close the port.

Steerable rotary drill bit assembly with pilot bit

A rotary drill bit assembly suitable for directionally drilling a borehole into an underground formation, the drill bit assembly having a bit body extending along a central longitudinal bit-body axis, and having a bit-body face at its front end, wherein an annular portion of the bit-body face is provided with one or more chip-making elements; a pilot bit extending along a central longitudinal pilot-bit axis, the pilot bit being partly arranged within the bit body and projecting out of the central portion of the bit-body face, the pilot bit having a pilot-bit face provided with one or more chip-making elements at its front end; a joint means arranged to pivotably connect the pilot bit to the bit body so that the bit-body axis and the pilot-bit axis can form a variable diversion angle; and a steering means arranged to pivot the pilot bit in order to steer the direction of drilling.

Through-drill string conveyed logging system

A system for drilling and logging of a wellbore formed in an earth formation is provided. The system comprises a log-ging tool string and a drill string having a longitudinal channel for circulation of drilling fluid, the drill string including a port providing fluid communication between the channel and the exterior of the drill string, the channel and the port being ar-ranged to allow the logging tool string to pass through the channel and from the channel through the port to a position exterior of the drill string. The system further comprises a re-movable closure element adapted to selectively close the port, wherein the logging tool string is provided with connecting means for selectively connecting the logging tool string to the closure element.

Mixed oxide material, electrode and method of manufacturing the electrode and electrochemical cell comprising it

The invention relates to a mixed oxide material with a high electron conductivity, of empirical formula ABOY, where y .noteq. 3 and where A comprises at least one metal selected from Na, K, Rb, Ca, Ba, La, Pr, Sr, Ce, Nb, Pb, Nd, Sm and Gd, and B comprises at least one metal selected from the group consisting of Cu, Mg, Ti, V, Cr, Mn, Fe, Co, Nb, Mo, W and Zr, where A and B cannot both be Nb and where the compound SrVO2.5 is excluded. The material may be a perovskite-type material, in which y = 3-.delta. and .delta. .noteq. 0, with values for .delta. in the range from approximately -0.2 to approximately -0.05 or in the range from +0.05 to +0.7. The material may also be a Brown-Millerite-type material, for which y = 2.5-.xi. and .xi. has a value in the range from approximately -0.2 to approximately -0.05 or in the range from +0.05 to approximately 0.3. The invention also describes an electrode for an electrochemical cell which can be produced from a mixed oxide material of this type, a method for producing an electrode from a mixed oxide material and an electrochemical cell which comprises at least one electrode of this type made from mixed oxide material according to the invention.

Mixed oxide material, electrode and method of manufacturing the electrode and electrochemical cell comprising it

The invention relates to a mixed oxide material with a high electron conductivity, of empirical formula ABOY, where y ≠ 3 and where A comprises at least one metal selected from Na, K, Rb, Ca, Ba, La, Pr, Sr, Ce, Nb, Pb, Nd, Sm and Gd, and B comprises at least one metal selected from the group consisting of Cu, Mg, Ti, V, Cr, Mn, Fe, Co, Nb, Mo, W and Zr, where A and B cannot both be Nb and where the compound SrVO2.5 is excluded. The material may be a perovskite-type material, in which y = 3-δ and δ ≠ 0, with values for δ in the range from approximately -0.2 to approximately -0.05 or in the range from +0.05 to +0.7. The material may also be a Brown-Millerite-type material, for which y = 2.5-κ and κ has a value in the range from approximately -0.2 to approximately -0.05 or in the range from +0.05 to approximately 0.3. The invention also describes an electrode for an electrochemical cell which can be produced from a mixed oxide material of this type, a method for producing an electrode from a mixed oxide material and an electrochemical cell which comprises at least one electrode of this type made from mixed oxide material according to the invention.

Hot gas piston machine.

Apparatus for condensing shipboard cargos of vaporizable liquid

Method for high speed stranding of aramid yarns

The invention pertains to a method for stranding aramid yarn around an endless core, wherein the core is provided for a stranding step to a stranding apparatus comprising at least one yarn bobbin, wherein during operation the bobbin revolves around its own axis and the bobbin revolves around the core, and unwinding the yarn from the bobbin around the core to provide a core surrounded by the yarn, wherein the yarn is a continuous aramid yarn provided with 0.05 to 0.95 wt%, based on the weight of the aramid, of a finish comprising an organophosphorus compound, wherein the organophosphorus compound is a compound of the formula X1X2X3P=O, wherein X1, X2, and X3 are independently selected from Y1-, Y1-O-, and M-O, wherein Y1 is a branched or straight-chain C1-C20 alkyl, aryl or alkenyl, with M being selected from Li, Na, K, or ammonium, with the proviso that at least one of X1, X2, or X3 is selected from Y1- or Y1-O-, wherein the different types of Y1 may be the same or different. In one embodiment, the continuous aramid yarn is provided with 0.10 to 0.50 wt% of the finish. It has been found that the use of a relatively minor amount of a finish comprising a specific organophosphorus compound results in an improved package stability on a rotating server with a rolling yarn take-off. Consequently, packages of aramid yarns provided with this finish allow for high speed stranding of aramid yarn around an endless core.

Well string assembly

Binocular binoculars

Injecting a fluid into a borehole in front of the drill bit

Corrosion-resistant mirror.

La invención se refiere a un espejo, que incluye una lámina de vidrio y una capa de plata aplicada al vidrio y que tiene, en su parte posterior un recubrimiento protector que incluye una capa de pintura alquídica seca y curada y una capa de pintura de poliuretano seca y curada, la capa alquídica se encuentra entre la capa de plata y la capa de poliuretano. La invención también se refiere al uso del mismo para desviar la luz solar a un colector de calor. La invención se refiere también al método para fabricar un espejo que incluye: depositar una capa de plata sobre una lámina de vidrio por medio de una solución de plateado; aplicar una capa de pintura alquídica que tiene una viscosidad de 25 a 110 segundos, medida con una copa Ford No. 4, sobre la capa de plata; secar y curar la capa de pintura alquídica; aplicar una capa de pintura de poliuretano que tiene una viscosidad de 25 a 110 segundos, medida con una copa Ford No. 4,sobre la capa alquídica; y secar y curar la capa de pintura de poliuretano.

Ranking content using content and content authors

Methods, systems, and apparatus, including computer program products for identifying original content. In one aspect a method is described that includes identifying a first document in a collection of documents. The first document contains a content piece and the content piece does not occur in any earlier document in the collection. The first document is associated with a first author and the first author associated with a first rank. The first rank of the first author is determined using a score of the content piece. The score is a figure of merit of the content piece.

Drill bit and method for inserting, expanding, collapsing, and retrieving drill bit

A drill bit comprising a bit body connectable to a drill string at an first end, which bit body is provided with a longitudinal pas-sageway extending from an opening at the first end to a port at a second end a closure element for closing the passageway, when the closure ele-ment is in a closing position, which closure element is removable, and wherein the closure element comprises a first and a second member which are movable relative to each other between an expanded configuration and a collapsed configuration, in which collapsed configuration, the closure el-ement is retractable through the passageway to the first end.

Methods for installing sensors in a borehole

A method of installing a sensor in a borehole drilled through underground formations, wherein the borehole is drilled with a hollow drill string formed from a series of pipe sections connected end-to-end, a drill bit being positioned at one end of the drill string and having a closure member that provides an opening between the borehole and the inside of the drill string, the method comprising: drilling the borehole to a predetermined; partially withdrawing the drill string from the borehole so that the drill bit is positioned above the predetermined depth; lowering a sensor inside the drill string by means of a cable; operating the closure so that the sensor can pass out of the drill string into the borehole; and progressively withdrawing the drill string and drill bit from the borehole over the cable so as to leave the sensor in the borehole.

Labeling events in historic news

A system identifies a set of documents from a corpus of documents that are relevant to a word, phrase or sentence and that were published at approximately a same time period, where each document of the set of documents includes news content and has an associated headline. The system extracts headlines from the set of documents and derives a score for each headline of the extracted headlines based on how many times selected words in each headline occurs among all of the extracted headlines.

Process for preparing 1,4,7,10-tetraazacyclododecane and N-acyl derivatives thereof

1,4,7,10-Tetraazycyklododekan neboli cyklen a jeho N-acylderiváty obecného vzorce I, kde Y je vodík, terc-butoxykarbonyl, methoxykarbonyl, ethoxykarbonyl, benzyloxykarbonyl, 9-fluorenylmethoxykarbonyl, se připraví elektrofilně katalyzovaným přesmykem (cyklotetramerací) N-acylaziridinů obecného vzorce II, kde Y je terc-butoxykarbonyl, methoxykarbonyl, ethoxykarbonyl, benzyloxykarbonyl nebo 9-fluorenylmethoxykarbonyl. 1,4,7,10-Tetraazycyclododecane or Cyclene and its N-acyl derivatives of Formula I wherein Y is hydrogen, tert-butoxycarbonyl, methoxycarbonyl, ethoxycarbonyl, benzyloxycarbonyl, 9-fluorenylmethoxycarbonyl, are prepared by electrophilically catalyzed cyclotetrameration of N-acylaziridines Formula II wherein Y is tert-butoxycarbonyl, methoxycarbonyl, ethoxycarbonyl, benzyloxycarbonyl or 9-fluorenylmethoxycarbonyl.

Tracer release method for monitoring fluid flow in a well

A tracer release method for monitoring fluid flow in a well utilizes a deformable container comprising a liquid tracer material which container has an outlet which debouches into the neck portion of a venturi in a well conduit. The container has a wall which is at least partly exposed to the fluid pressure at the relatively wide in- or outlet of the venturi, so that an amount of tracer is injected continuously or discontinuously into the well effluents which is proportional to the pressure difference p across the venturi, which pressure difference p is indicative of the fluid density ς and squared fluid velocity ω.

Bacteriophage detection

The present invention relates to a kit suitable for detection of Streptococcus thermophilus infecting phages, said kit comprising: (a) a first primer pair suitable to generate an amplicon characteristic for a 987 phage; and (b) a second primer pair suitable to generate an amplicon characteristic for a 5093 phage. Further, the present invention relates to a method for detecting the presence of Streptococcus thermophilus infecting phages in a sample.

Method for high speed stranding of aramid yarns

Engine-unit consisting of at least one working cylinder and at least one compressor cylinder

Multifunctional catalyst for the conversion of carbon dioxide

The present invention concerns a multifunctional catalyst for the conversion of CO2 into useful products, such as CO via the reverse water gas shift reaction. The catalyst according to the invention efficiently combined a water sorption functionality with at least one catalytic functionality into a single particle, by having a solid water sorbent impregnated with at least one metal capable of converting CO2 from a gaseous mixture comprising H2 and CO2. The catalyst according to the invention allows for higher selectivity in the conversion of CO2, at more lenient conditions in terms of temperature and pressure, and improved stability of the catalyst itself. The invention also concerns a process for converting CO2, utilizing the catalyst and the use of the catalyst in the conversion of CO2.

Bifidobacterium longum strain ah121a

Various novel Bifidobacterium longum bifidobacteria strains are described herein, including Bifidobacterium longum strain AH121A, deposited at the National Collections of Industrial and Marine Bacteria under the accession number NCIMB 41675. Bifidobacterium longum strain AH121A may be useful for the control and treatment of inflammatory disease.

Hot gas piston machine with two or more closed circuits

Hot-gas reciprocating machine

Multi-stage cooling system

NMR logging assemby.

A logging assembly for application in a wellbore formed in an earth formation is provided. The assembly comprises a casing suitable to be lowered through the wellbore and to be arranged in a selected part thereof, and an NMR logging device comprising magnetising means for inducing a magnetic field into a selected zone of the earth formation, antenna means for transmitting radio-frequency (RF) signals into the selected zone and for receiving response RF signals from the selected zone, and data collecting means for collecting data representing the response RF signals, which data collecting means is removably arranged in the interior of the casing. The means for inducing the magnetic field includes a magnetised section of the casing.

Method for high speed stranding of aramid yarns.

La invención se refiere a un método para trenzar hilo de aramida al rededor de un núcleo sin fin, en donde se proporciona el núcleo para un paso de trenzado a un aparato de trenzado que comprende por lo menos un carrete de hilo, en donde durante la operación el carrete gira al rededor de su propio eje y el carrete gira al rededor del núcleo, y desenredar el hilo desde el carrete al rededor del núcleo para proporcionar un núcleo rodeado por el hilo, en donde el hilo es un hilo de aramida continuo provisto de 0.05 a 0.95 % en peso con base en el peso de la aramida, de un acabado que comprende un compuesto organofosforado, en donde el compuesto organofosforado es un compuesto de la fórmula X1X2X3P=O, en donde X1, X2, y X3 se seleccionan de manera independiente de Y1-, Y1-O- , y M-O, en donde Y1 es un alquilo, arilo o alquenilo de C1C20 ramificado o de cadena recta, y en donde M se selecciona de Li, Na, K, o amonio, con la condición de que por lo menos uno de X1, X2 o X3 se seleccione de Y1- o Y1-O-, en donde los distintos tipos de Yl pueden ser iguales o distintos; en una modalidad, el hilo de aramida continuo está provisto con 0.10 hasta 0.50 % en peso del acabado; se ha encontrado que el uso de una cantidad relativamente pequeña de un acabado que comprende un compuesto organofosforado específico tiene como resultado una estabilidad de paquete mejorado en un servidor giratorio con una entrega de hilo giratoria. En consecuencia, los paquetes de hilos de aramida provistos de este acabado permiten el trenzado a alta velocidad al rededor de un núcleo sin fin.

Plastic pipe branching systems, in particular for irrigation purposes

CORROSION RESISTANT MIRROR

L'invention concerne un miroir comprenant une feuille de verre et une couche d'argent appliquée sur le verre et muni en son dos d'un revêtement de protection comprenant une couche de peinture séchée et réticulée du type alkyde et une couche de peinture séchée et réticulée du type polyuréthane, la couche alkyde étant situé entre la couche d'argent et la couche polyuréthane. L'invention concerne également son utilisation pour dévier la lumière solaire vers un collecteur de chaleur. L'invention concerne également le procédé de fabrication d'un miroir comprenant : - le dépôt d'une couche d'argent sur une feuille de verre à partir d'une solution d'argenture, puis - l'application du côté de la couche d'argent d'une couche de peinture alkyde de viscosité comprise entre 25 et 110 seconde mesuré à la coupe Ford n°4, puis - séchage et réticulation de la couche de peinture alkyde, puis - l'application du côté de la couche alkyde d'une couche de peinture polyuréthane de viscosité comprise entre 25 et 110 seconde mesuré à la coupe Ford n°4, puis - séchage et réticulation de la couche de peinture polyuréthane. The invention relates to a mirror comprising a glass sheet and a silver layer applied to the glass and provided on its back with a protective coating comprising a layer of alkyd-type dried and cross-linked paint and a layer of dried paint and crosslinked polyurethane type, the alkyd layer being located between the silver layer and the polyurethane layer. The invention also relates to its use for deflecting sunlight to a heat collector. The invention also relates to the method of manufacturing a mirror comprising: depositing a silver layer on a glass sheet from a silvering solution, and then applying the layer side of silver with a layer of alkyd paint with a viscosity of between 25 and 110 seconds measured at the Ford Cup No. 4, then - drying and crosslinking of the alkyd paint layer, then - the application of ...

Riflescope with variable magnification

The invention relates to a telescopic sight (1) with variable magnification in which the magnification is adjusted by an adjusting ring (4). According to the invention, the telescopic sight housing (2) and eyepiece supports are made from one piece.

Injecting a fluid into a borehole ahead of the bit

A method and system for introducing a fluid into a borehole (2), in which there is arranged a tubular drill string (3) including a drill bit (1), wherein the drill bit (1) is provided with a passageway (8, 20) between the interior (3a) of the drill string (3) and the borehole (2), and with a removable closure element (10) for selectively closing the passageway in the passageway in a closing position, and wherein there is further provided a fluid injection tool comprising a tool inlet and a tool outlet, the method comprising passing the fluid injection tool through the drill string to the closure element, and using it to remove the closure element from the closing position; passing the fluid injection tool outlet through the passageway, and introducing the fluid into the borehole from the interior of the drill string through fluid injection tool into the borehole.

Process and device for preparing the walls of a mold for molding or shaping to make them ready for the next molding cycle

In a process and in a device (10) for preparing the mold walls (12a, 12b) of a mold (12, 12) for the molding or shaping of a molded part after completion of the molding cycle and after removal of the molded part from the mold (12) to make the mold walls ready for the next molding cycle, the tempering of the mold walls (12a, 12b) and the coating of the walls with mold wall treatment agent are carried out independently of each other, i.e., without any time overlap, and in a controlled manner, preferably in a program-controlled manner. To apply the coating, preferably a spray element with centrifugal atomization and air control is used, the mold walls preferably being coated with essentially solvent-free mold wall treatment agent.

Method for removing permanently bounded iron containing elements from aluminium alloy scrap

Sposób usuwania ze złomu stopów aluminium trwale związanych elementów ze stopów zawierających żelazo charakteryzuje się tym, że na sicie wykonanym z prętów lub taśm stalowych, powlekanych materiałem ceramicznym, stanowiącym mieszaninę tlenku aluminium i krzemu, wyposażonym w obejmę, wykonaną z blachy stalowej, umieszcza się kawałki złomu stopów aluminium trwale związanych z elementami ze stopów zawierających żelazo, przy czym masa kawałków złomu stopów aluminium umieszczonych na sicie wynosi 1 - 10% nominalnej pojemności pieca indukcyjnego określonej w kg. Następnie sito wraz ze znajdującym się na nim złomem opuszcza się do pieca i zanurza w ciekłej kąpieli o temperaturze 750 - 830°C, której masa wynosi 25 - 35% nominalnej pojemności pieca określonej w kg, utworzonej z wcześniej dodanego niezanieczyszczonego złomu stopów aluminium lub kąpieli celowo pozostawionej z poprzedniego wytopu. Po przejściu stopów aluminium z umieszczonego na sicie złomu w stan ciekły, sito wyciąga się z pieca wraz z elementami w stanie stałym ze stopów zawierających żelazo, po czym schłodzoną kąpiel wygrzewa się do temperatury 750 - 830°C. Z kolei opuszcza się na sicie kolejną partię przetwarzanego złomu stopów aluminium i prowadzi proces do wyczerpania nominalnej pojemności pieca. The method of removing permanently bonded elements made of iron-containing alloys from scrap is characterized by the fact that pieces of pieces are placed on a sieve made of steel bars or strips, coated with a ceramic material, consisting of a mixture of aluminum and silicon oxide, equipped with a clamp made of steel sheet. of scrap of aluminum alloys permanently bonded to elements of iron-containing alloys, the weight of the pieces of aluminum alloy scrap placed on the sieve is 1 - 10% of the nominal capacity of the induction furnace determined in kg. Then, the sieve with its scrap is lowered into the furnace and immersed in a liquid bath at a temperature of 750-830 ° C, the mass of which is 25-35% of the ...

Device with at least one seal designed as a rolling membrane between two coaxially arranged elements which can be moved relative to one another

Wellbore logging system

A logging system for use in a borehole formed in an earth formation, comprising a tubular element to be installed in the borehole, and a logging member including a conduit having an inlet opening and being movable in radial direction of the tubular element between a retracted position in which the logging member is substantially arranged within the tubular element and an ex-tended position in which the logging member extends beyond the tubular element so that said inlet opening is in fluid communication with the earth formation when the tubular element is installed in the borehole, the logging system further comprising an activating device for moving the logging member between the retracted position and the extended position thereof.

Inhibitors of vap-1

Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.

Piston cylinder means with fluid-coupled drive means and rolling diaphragm seal

Product

An isolated Bifidobacteria DNA fragment comprises nucleic acid selected from sequence ID No. 1, sequence ID No. 2 or sequence ID No. 3. A protein having sequence ID No. 4, sequence ID No. 5, sequence ID No. 6, sequence ID No. 7, sequence ID No. 8 or sequence ID No. 9 is also disclosed as are DNA fragments comprising sequence ID No. 10 or 11 and proteins encoded thereby. A two-component signal transduction system comprises a gene encoding sequence ID No. 4 and a gene encoding sequence ID No. 5, a gene encoding sequence ID No. 6 and a gene encoding sequence ID No. 7 or a gene encoding sequence ID No. 8 and a gene encoding sequence ID No. 9. The Bifidobacteria may be Bifidobacterium infantis UCC35624.

Multifunctional catalyst for the conversion of carbon dioxide

The present invention concerns a multifunctional catalyst for the conversion of CO 2 into useful products, such as CO via the reverse water gas shift reaction. The catalyst according to the invention efficiently combined a water sorption functionality with at least one catalytic functionality into a single particle, by having a solid water sorbent impregnated with at least one metal capable of converting CO 2 from a gaseous mixture comprising H 2 and CO 2 . The catalyst according to the invention allows for higher selectivity in the conversion of CO 2 , at more lenient conditions in terms of temperature and pressure, and improved stability of the catalyst itself. The invention also concerns a process for converting CO 2 , utilizing the catalyst and the use of the catalyst in the conversion of CO 2 .

Method and apparatus for configuration of a motion controller

In one aspect, a method of facilitating configuration of a motion controller by a user includes depicting, on a display, a set of configuration blocks, each configuration block representing a corresponding category of configuration parameters, among a universe of configuration parameters defined for a motion controller, each configuration block being configurable by a user based on the user entering corresponding configuration parameter values. The configuration blocks comprise an amplifier block, a motor block, an encoder and a hardware interface block. The configuration of the configuration blocks by the user is restricted according to a predefined hierarchical set of dependencies among the configuration blocks with respect to their corresponding configuration parameters.

Hot-gas reciprocating engine construction

Anhydrous release agent / lubricant for treating the walls of a mold for primary shaping or forming

Eine wasserfreie Zusammensetzung zur Behandlung der Wände einer Form zur Urformung oder Umformung enthält bis zu 30% eines Polyolefin- oder/und Paraffin-Wachses und mindestens 70% Öl, wobei das Öl ein Silikonöl, ein synthetisches Öl, ein pflanzliches Öl oder ein Mineralöl oder eine Mischung mehrerer solcher Öle ist. Zur Herstellung einer erfingungsgemäßen wasserfreien Zusammensetzung werden ein oder mehrere Wachse mit dem oder den Ölen und eventuellen Additiven bis zur Homogenität vermischt. Die erfindungsgemäßen wasserfreien Trenn-/Schmiermittel dienen insbesondere zur Behandlung der Wände zur Urformung oder Umformung. An anhydrous composition for treating the walls of a mold for primary shaping or forming contains up to 30% of a polyolefin or / and paraffin wax and at least 70% oil, the oil being a silicone oil, a synthetic oil, a vegetable oil or a mineral oil or is a mixture of several such oils. To produce an anhydrous composition according to the invention, one or more waxes are mixed with the oil or oils and any additives until homogeneous. The water-free release agents / lubricants according to the invention are used in particular for treating the walls for primary shaping or shaping.

Tracer release method for monitoring fluid flow in a well

A tracer release method for monitoring fluid flow in a well utilizes a deformable container comprising a liquid tracer material which container has an outlet which debouches into the neck portion of a venturi in a well conduit. The container has a wall which is at least partly exposed to the fluid pressure at the relatively wide in- or outlet of the venturi, so that an amount of tracer is injected continuously or discontinuously into the well effluents which is proportional to the pressure difference p across the venturi, which pressure difference p is indicative of the fluid density .rho. and squared fluid velocity .upsilon..

Phage resistant lactic acid bacteria

Bifidobacterium longum

The multiple embodiments described herein comprise the genome of a probiotic Bifidobacterium longum bifidobacteria strain and genes encoded by the genome. Various novel Bifidobacterium longum are described.

Lubricant for hot forging applications

A substantially lead-free lubricant for use in hot forging of metals, especially forging of aluminum and aluminum alloy components. The lubricant comprises one or more oils, graphite, and one or more phosphorus-based additives. Additional additives, such as metallic lubricants and dispersants may also be included. The lubricant does not burn when subjected to temperatures in excess of 300° C.

Method for enzymatic modification of esterified starch

Vessel more particularly ships

Methods, systems, and media for generating and evaluating street grids

Methods, systems, and media for generating and evaluating street grids are provided. In some embodiments, the method comprises: receiving, using a hardware processor, street grid information corresponding to a plurality of locations, wherein the street grid information corresponding to a location in the plurality of locations is associated with vehicular traffic information; training, using the hardware processor, a pedestrian comfort model using the street grid information and the vehicular traffic information from each of the plurality of locations, wherein an output of the pedestrian comfort model is a predicted pedestrian comfort score that is based on traffic congestion from the vehicular traffic information; receiving, using the hardware processor, a plurality of potential street grids; evaluating, using the hardware processor, each potential street grid in the plurality of potential street grids using the trained pedestrian comfort model, wherein the trained pedestrian comfort model generates predicted pedestrian comfort scores for portions of each potential street grid; and generating, using the hardware processor, an augmented map of each potential street grid that presents the predicted pedestrian comfort scores for each portion of each potential street grid.

CARCASE OF SEAT OF MOTOR VEHICLE

Inhibitors of VAP-1

Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.

Process for preparation of 5-fluoro-1H-pyrazolo [3,4-b] pyridin-3-amine and derivatives thereof

Un proceso para preparación de un compuesto de fórmula 5: **Fórmula** que comprende el paso de someter selectivamente a des-cloración un compuesto de fórmula 1: 5 **Fórmula** en condiciones de des-cloración adecuada para formar un compuesto de fórmula 2: **Fórmula** A process for preparing a compound of formula 5: ** Formula ** comprising the step of selectively dechlorinating a compound of formula 1: 5 ** Formula ** under suitable dechlorination conditions to form a compound of formula 2: ** Formula **

Injecting a fluid into a borehole ahead of the bit

A method and system for introducing a fluid into a borehole (2), in which there is arranged a tubular drill string (3) including a drill bit (1), wherein the drill bit (1) is provided with a passageway (8, 20) between the interior (3a) of the drill string (3) and the borehole (2), and with a removable closure element (10) for selectively closing the passageway in the passageway in a closing position, and wherein there is further provided a fluid injection tool comprising a tool inlet and a tool outlet, the method comprising passing the fluid injection tool through the drill string to the closure element, and using it to remove the closure element from the closing position; passing the fluid injection tool outlet through the passageway, an d introducing the fluid into the borehole from the interior of the drill strin g through fluid injection tool into the borehole.

Glucose sensitive insulin derivatives

Probing mechanical properties of biological matter

A method for probing mechanical properties of cellular bodies is described wherein the method includes: providing a plurality of particles in a fluid medium contained in a holding space of a sample holder, each of the plurality of particles being attached to a cellular body and each cellular body being positioned on a surface of the holding space; generating a resonant bulk acoustic wave in the holding space, the resonant bulk acoustic wave exerting an acoustic force on each of the plurality of particles in a direction away from the surface of the holding space or in a direction towards the surface of the holding space, each of the plurality of particles having an acoustic contrast factor and a size, the acoustic contrast factor and the size being selected such that the force exerted on a particle is larger than the force exerted on the cellular body to which the particle is attached; and, for at least part of the particles attached to the cellular bodies, measuring a displacement of a particle in response to the exertion of the force on the particle, the measured displacement being associated with at least one mechanical property of the cellular body attached to the particle.

drill pipe

Methods, systems, and media for initiating and monitoring instances of workflows

Methods, systems, and media for initiating and monitoring instances of workflows are provided. In some embodiments, the method comprises: retrieving, using a hardware processor, a workflow description that includes a plurality of steps and that corresponds to a group of simulations in a generative design system for generating a plurality of design iterations; generating, using the hardware processor, a graph that represents a workflow and that indicates interconnections between the plurality of steps; determining, using the hardware processor, information for the generative design system to performs the plurality of steps included in the workflow based on the graph, wherein the information for the generative design system includes determining that a first subset of steps are to be batched together as a first batch and determining that a second subset of steps are to be batched together as a second batch, and wherein the first batch and the second batch are executed as a group of steps; determining, using the hardware processor, an execution strategy for performing the plurality of steps included in the workflow based on the determined information for the generative design system; causing, using the hardware processor, the generative design system to execute the plurality of steps in the workflow using the execution strategy; and updating, using the hardware processor, a user interface with one or more design iterations of the plurality of design iterations upon generation by the generative design system.

Method and system for damping vibrations in a tool string system

The invention provides a control system and method for limiting vibrations in a tool string system. The system comprises a pump connected to a rotatable tool string driven by a drive system. The control system comprises feedback of both torque and rotational speed signals into a controller. An objective of said controller is to maintain the drive speed over torque ratio equal to the connected tool string impedance (Z). A secondary objective, for lower frequencies, is to approach and maintain a setpoint speed as drive rotation speed. The system includes a rotational speed sensor and a torque sensor, with the latter optionally replaced by a motor torque signal already available from a variable frequency drive (VFD) for an AC motor and the current safeguarding signal for a DC motor.

Process for preparing 5-fluoro-1h-pyrazolo [3, 4-b] pyridin-3-amine and derivatives thereof

The present invention relates to a process for the synthesis of 5-fluoro-1H-pyrazolo [3, 4-b]pyridin-3-amine in high yield and purity. The present invention also relates to processes for the synthesis of 5-fluoro-1H-pyrazolo [3, 4- b] pyridin-3-amine derivatives. These processes are useful for preparing biologically active compounds, particularly certain GSK-3 inhibitors, or deriva-tives thereof. Reagents and conditi ons : i. Pd ( OAc )2, PPh3, Et3N, H2CO2; i i. 1 )(COCl)2, CH2Cl2, cat. DMF; 2 ) NH3 (g ), dioxane, i i i. TFAA, Et3N, CH2Cl2, O°C; iv. H2NNH2. H2O, n-butanol, reflux.