METHOD AND SYSTEM FOR MANAGING ONLINE ADVERTISING OBJECTS USING TEXTUAL METADATA TAGS

A method for managing online advertising placements includes associating a plurality of textual metadata tags with at least one advertising placement, and generating a bid recommendation for the at least one advertising placement associated with the plurality of textual metadata tags. 1. A method for managing online advertising placements , comprising acts of:associating a plurality of textual metadata tags with at least one advertising placement in a plurality of advertising placements; andgenerating a bid recommendation for the at least one advertising placement associated with the plurality of textual metadata tags.2. The method of claim 1 , further comprising an act of determining a relative priority of each to textual metadata tag in the plurality of textual metadata tags claim 1 , wherein the act of generating a bid recommendation is performed with reference to the relative priority.3. The method of claim 1 , further comprising an act of permitting the at least one advertising placement to be associated with at most one exclusive textual metadata tag.4. The method of claim 1 , further comprising an act of calculating a performance metric for the at least one advertising placement claim 1 , wherein the act of generating a bid recommendation is carried out with reference to the performance metric.5. The method of claim 1 , further comprising acts of:receiving user input from a user; andforming the user input into at least one textual metadata tag.6. The method of claim 5 , wherein the act of forming the user input into at least one textual metadata tag comprises the act of forming claim 5 , responsive to the user input satisfying at least one predetermined syntax rule claim 5 , the user input into at least one textual metadata tag.7. The method of claim 1 , wherein the act of associating the plurality of textual metadata tags with at least one advertising placement in a plurality of advertising placements includes acts of:associating at least one selection ...

EMBEDDED HARDWARE BASED SYSTEM WHICH PROVIDES REAL-TIME PRE-TRADE RISK ASSESSMENTS FOR MULTIPLE PARTIES AND METHOD THEREOF

A risk assessment system and method are provided that may be implemented as an embedded hardware based system and method that provide real-time pre-trade risk assessments for multiple parties, in addition to real-time market data and trading connectivity to a variety of liquidity venues. The liquidity venues may include regulated exchanges, ECNs and other financial institutions listing securities, options, futures, commodities, foreign exchange and other financial instruments. 1. An embedded risk assessment system , comprising:a surface;at least one client personality module, at least one market participant personality module, at least one liquidity venue personality module and at least one market data personality module each installed on the surface and electrically connected to each other;the at least one client personality module having a set of risk data for a particular client;the at least one market participant personality module storing a set of risk data for a broker in a liquidity venue;the at least one liquidity venue personality module allowing the at least one client personality module and the at least one market participant personality module to interact with the liquidity venue to send a trade and receive notifications of a completed trade;the at least one market data personality module gathering data about a particular market; andthe at least one client personality module, at least one market participant personality module and at least one liquidity venue personality module performing pre-trade risk assessment for the client with reduced latency.2. The system of further comprising a hot spare personality module installed on the surface that stores a set of code for each of the client personality module claim 1 , the market participant personality module claim 1 , the liquidity venue personality module and the market data personality module so that the hot spare personality module is swappable for any of the client personality module claim 1 , the ...

System and Method for Trading Debt Instruments

A system for facilitating debt instrument transactions has a processor for communication with a plurality of remote computers via a network. The processor is configured to store a data structure in a memory. The data structure has data items associated together as a user profile. The data items comprise data representative of a financial condition and creditworthiness for a user associated with the user profile. The processor is further configured to complete a debt instrument transaction between the user and a lender in response to inputs from a plurality of the remote computers. The processor is further configured to detect the completed debt instrument transaction, and in response to detection of the completed debt instrument transaction, automatically update the stored user profile based on the completed debt instrument transaction and republish the updated user profile so a lender may extend an offer to the user regarding another debt instrument transaction. 1. A system for facilitating debt instrument transactions , the system comprising:a processor for communication with a plurality of remote computers via a network; anda memory; store a data structure in the memory, the data structure comprising a plurality of data items associated together as a user profile, the data items comprising data representative of a financial condition and creditworthiness for a user associated with the user profile;', 'complete a debt instrument transaction between the user and a lender in response to inputs from a plurality of the remote computers;', 'detect the completed debt instrument transaction; and', 'in response to detection of the completed debt instrument transaction, automatically update the stored user profile based on the completed debt instrument transaction to thereby keep the user profile current such that a lender can review the updated user profile to make a decision on whether to extend an offer to the user regarding another debt instrument transaction., 'the ...

Integration of Graphical Application Content into the Graphical Scene of Another Application

This application describes a system that captures 3D geometry commands from a first 3D graphics process and stores them in a shared memory. A second 3D environment process creates a 3D display environment using a display and display hardware. A third process obtains the 3D commands and supplies them to the hardware to place 3D objects in the 3D environment. The result is a fused display environment where 3D objects are displayed along with other display elements. Input events in the environment are analyzed and mapped to the 3D graphics process or the environment where they affect corresponding processing.

SYSTEMS AND METHODS FOR PROVIDING REAL-TIME PRE-TRADE RISK ASSESSMENT

Systems and methods are disclosed that provide real-time pre-trade risk assessments for multiple parties. In one embodiment, systems and methods can be configured to receive a market order data packet, wherein the market order data packet comprises order information for a market order to be made at a liquidity venue. The market order data packet comprises a header portion and a payload portion, and the header portion comprises at least a portion of the order information. An order symbol is determined based on order symbol information in the header portion. Risk parameters are retrieved associated with the order symbol. It is determined whether or not a risk threshold is exceeded based on the risk parameters and the order information. A final market order data packet is generated for transmission to the liquidity venue based on the determining whether the risk threshold is exceeded. 1. A computer-implemented method comprising: the market order data packet comprises order information for a market order to be made at a liquidity venue,', 'the market order data packet comprises a header portion and a payload portion, and', 'the header portion comprises at least a portion of the order information;, 'receiving, by a computing system, a market order data packet, wherein'}determining, by the computing system, an order symbol based on order symbol information in the header portion;retrieving, by the computing system, risk parameters associated with the order symbol;determining, by the computing system, whether a risk threshold is exceeded based on the risk parameters and the order information; andgenerating, by the computing system, a final market order data packet for transmission to the liquidity venue based on the determining whether the risk threshold is exceeded.2. The computer-implemented method of claim 1 , whereinthe header portion comprises an assigned MAC address, andthe assigned MAC address comprises the order symbol information.3. The computer-implemented method ...

Screw-in pericardial leads and systems for delivering screw-in pericardial leads

Disclosed herein is a screw-in lead implantable in the pericardium of a patient heart and a system for delivering such leads to an implantation location. The leads include a helical tip electrode and a curvate body including a defibrillator coil with improved contact between the defibrillator coil and the patient heart. The delivery system includes a delivery catheter and lead receiving sheath disposed within the catheter. A fixation tine is disposed on one of the delivery catheter and the lead receiving sheath such that the delivery system may be anchored into the pericardium during fixation of the screw-in lead. In certain implementations, an implantable sleeve receives the leads to bias the defibrillator coil against the patient heart.

DOWNHOLE TOOL AND METHOD OF USE

A downhole tool suitable for use in a wellbore, the tool comprising a hybrid sleeve in the form of a mandrel sleeve; and a sleeve insert disposed within the mandrel sleeve. The tool further includes a first slip disposed about the mandrel sleeve; and a second slip disposed about the mandrel sleeve and proximate to a conical surface. There is a lower sleeve proximate to the second slip. 1. A downhole tool suitable for use in a wellbore , the tool comprising:a mandrel sleeve;a sleeve insert disposed within the mandrel sleeve;a first slip disposed about the mandrel sleeve;a second slip disposed about the mandrel sleeve and proximate to a conical surface; anda lower sleeve disposed proximate to the second slip, and threadingly engaged with the mandrel sleeve.2. The downhole tool of claim 1 , wherein the mandrel sleeve comprises a set of threads claim 1 , and wherein at least one of the first slip and the second slip have a one-piece configuration with at least partial connectivity around the entirety of a circular slip body claim 1 , and at least two grooves disposed therein.3. The downhole tool of claim 2 , the tool further comprising:a seal element; anda composite member disposed about the mandrel and in engagement with the seal element, wherein the composite member is made of a first material and comprises a first portion and a second portion, and wherein the first portion comprises at least one groove.4. The downhole tool of claim 2 , the tool further comprising:a first cone disposed around the mandrel sleeve and proximate a second end of a seal element; anda bearing plate disposed around the mandrel sleeve.5. The downhole tool of claim 2 , wherein the set of threads comprise one of shear threads or rounded threads.6. The downhole tool of claim 5 , wherein at least one of the first slip and the second slip are made of composite material.7. The downhole tool of claim 5 , wherein both the first slip and the second slip are made of metal.8. The downhole tool of claim 1 ...

Token-based data security systems and methods for structured data

A tokenization system receives a request for data anonymization, the request referencing structured data containing values of interest. Responsively, the tokenization system performs a tokenization operation on the structured data, generates a corresponding token, and replaces a value of interest with the corresponding token to produce an anonymized version of the structured data. The tokenization system stores the value of interest with the corresponding token in a secure data vault. Subsequently, the tokenization system may receive a request for revealing the anonymized version of the structured data containing the corresponding token. In response, the tokenization system can perform a reveal operation on the anonymized version of the structured data by querying the secure data vault for the corresponding token and retrieving the value of interest from the secure data vault using the corresponding token. The reveal operation produces a detokenized version of the structured data containing the value of interest.

SYSTEMS AND METHODS FOR PROVIDING REAL-TIME PRE-TRADE RISK ASSESSMENT

Systems and methods are disclosed that provide real-time pre-trade risk assessments for multiple parties. In one embodiment, a Programmable Logic Device (PLD) may be embedded within an Automated Trading Systems (ATS) architecture by utilizing the Intel socket G or the PCIe interface to provide pre-trade risk functionality. The system may also provide a method for interacting with the ATS DRAM or L1 cache to provide faster access to orders in ATS memory for PLDs. The system may use the Quick Path Interconnect between an embedded processor and a PLD to transfer memory maps. The system may also add additional libraries to an ATS processor to accelerate the transfer or memory maps to a PLD. The system also may use system interrupts to cancel erroneous orders within an ATS processor from a PLD housed within the same physical architecture. 1. A system comprising:a first memory;a shadow map of the first memory; write market order information to the first memory based on the market data information,', 'update the shadow map based on the market order information written to the first memory, and', 'prepare a market order for transmission to a market venue based on the market order information; and, 'an automated trading system (ATS) processor in communication with the first memory and the shadow map, the ATS processor configured to receive market data information,'} obtain the market order information from the shadow map, and', 'performance of the trade risk assessment and preparation of the market order are simultaneous.', 'perform a trade risk assessment based on the market order information obtained from the shadow map, wherein'}], 'a trade risk processor in communication with the ATS processor, the trade risk processor configured to'}2. The system of claim 1 , wherein the trade risk processor is in communication with the ATS processor via a PCIe connection.3. The system of claim 2 , wherein the first memory comprises a dynamic random access memory.4. The system of claim 3 ...

Polymer-based arterial hemangioma embolization device, manufacturing method and application of same

A polymer-based embolization device comprises a helix constructed by a linear structure. The linear structure is either a fibrous structure or composed of an A structure ( 1 ) and a B structure ( 2 ), wherein the A structure ( 1 ) is a protrusion on the linear structure and the B structure ( 2 ) is a pillar-shaped structure positioned between two A structures ( 1 ) for connecting the two A structures ( 1 ). The embolization device adopts a linear structural design and is integrally manufactured using a polymer material via a four-axis rapid forming system or via a compression method, thereby addressing issues of generation of image artifacts during CT and magnetic resonance imaging. The combination of design, material, and technique of the invention provides the device with improved flexibility and embolus formation, and can satisfy different clinical requirements. When a biodegradable macromolecular material is selected for manufacturing, blood vessel obstruction caused by implant degrading can be avoided, allowing the blood vessel to return to a normal structural state.

SYSTEM AND METHOD FOR IDENTIFYING MANUFACTURED PARTS

A system and method can identify manufactured parts. A user can select a particular manufactured part, which can be out-of-specification. The system can retrieve test data for the selected part and for other manufactured parts. The system can normalize the retrieved test data against historical means and historical standard deviations to form normalized test data. The system can correlate the normalized test data for the selected part against normalized test data for each of the other manufactured parts to form correlation values. The system can display the correlation values with identifiers corresponding to the manufactured parts. Each correlation value can represent a degree of similarity between the selected part and a respective manufactured part. The manufactured parts with the highest correlation values can have the same failure mechanism as the selected part, which can help diagnose why the selected part can be out-of-specification. 1. A system for identifying manufactured parts , comprising:a server configured to store test data for a plurality of manufactured parts, the plurality of manufactured parts having same nominal physical properties and differing from one another due to manufacturing imperfections, the test data comprising a plurality of numerical values for each manufactured part;a processor; and provide a user interface, the user interface including user interface elements to allow for selections;', 'receive, as input on the user interface, a selection of a selected manufactured part, from the plurality of manufactured parts;', 'retrieve, from the server, test data for the plurality of manufactured parts;', 'normalize the retrieved test data against respective historical means and respective historical standard deviations to form normalized test data;', 'correlate the normalized test data for the selected manufactured part with the normalized test data for each of the other manufactured parts in the plurality to form a plurality of correlation ...

REVOCATION AND UPDATING OF COMPROMISED ROOT OF TRUST (ROT)

Disclosed are implementation for revoking and updating a compromised root-of-trust (ROT), including a method comprising determining whether a current validation value, representative of an expected value resulting from application of a validation function to a current certificate, is to be replaced, with the current validation value being stored in a write-restricted non-volatile memory unit of the device. The method also comprises determining at boot time whether a physical presence indicator, configured to be non-actuatable from non-proximate locations, is set to a value indicating that an actuation mechanism (for actuating the physical presence indicator so as to cause content change for the write-restricted memory), has established physical presence with the device, and providing a new validation value in response to determining that the current validation value is to be replaced and that the physical presence indicator indicates that physical presence has been established. 1. A method comprising:determining whether a current validation value, representative of an expected value resulting from application of a validation function to current certificate data used by a computing device, is to be replaced, wherein the current validation value is stored in a write-restricted non-volatile memory unit of the computing device;determining at boot time whether a physical presence indicator, configured to be non-actuatable from non-proximate locations, is set to a value indicating that an actuation mechanism, configured to cause actuation of the physical presence indicator in order to cause content change for the write-restricted non-volatile memory unit, has established physical presence with the computing device; andproviding a new validation value, representative of a new expected value resulting from application of the validation function to new certificate data used by the computing device, in response to determining that the current validation value is to be ...

Chemical compounds

The specification relates to compounds of Formula (I): and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of cell proliferative disorders.

CONFECTIONERY CAPABLE OF ASSUMING AN ORNAMENTAL SHAPE, AND APPARATUS AND METHOD FOR PREPARING THE SAME

A formula, apparatus and method of manufacturing a confectionery with an ornamental shape is disclosed. The invention comprises a jacket dough capable of being formed into an ornamental shape, said jacket dough further comprising flour; a leavening system; an oil, water and emulsifier system; sweeteners; flavoring additives; and coloring additives. 1. A composition comprising a jacket dough capable of being formed into an ornamental shape , said jacket dough further comprising:flour;a leavening system;an oil, water and emulsifier system;sweeteners;flavoring additives; andcoloring additives.2. The composition of claim 1 , wherein said water comprises 14.74 wt % of the jacket dough.3. The composition of claim 1 , wherein:said flour comprises whole wheat flour;said leavening system comprises sodium bicarbonate and monocalcium phosphate;said oil, water and emulsifier system comprises canola oil and GMO-free soy lecithin;said sweeteners comprises GMO-free granular sugar and tapioca syrup;said flavoring additives comprises salt, quick oats, fruit flavoring and organic soy fiber; andsaid coloring additives comprises caramel coloring.4. The composition of claim 3 , wherein:said whole wheat flour comprises approximately 30.0-40.0 wt % of the jacket dough;said sodium bicarbonate comprises approximately 0.15=0.225 wt % of the jacket dough;said monocalcium phosphate comprises approximately 0.05-0.125 wt % of the jacket dough;said canola oil comprises approximately 7.0-13.0 wt % of the jacket dough;said water comprises approximately 12.5-17.5 wt % of the jacket dough;said GMO-free soy lecithin comprises approximately 0.1-0.225 wt % of the jacket dough;said GMO-free granular sugar comprises approximately 4.0-6.5 wt % of the jacket dough;said tapioca syrup comprises approximately 17.5-22.5% wt % of the jacket dough;said salt comprises approximately 0.25-0.75 wt % of the jacket dough;said quick oats comprises approximately 7.5-12.5 wt % of the jacket dough;said fruit flavoring ...

EMBEDDED HARDWARE BASED SYSTEM WHICH PROVIDES REAL-TIME PRE-TRADE RISK ASSESSMENTS FOR MULTIPLE PARTIES AND METHOD THEREOF

A risk assessment system and method are provided that may be implemented as an embedded hardware based system and method that provide real-time pre-trade risk assessments for multiple parties, in addition to real-time market data and trading connectivity to a variety of liquidity venues. The liquidity venues may include regulated exchanges, ECNs and other financial institutions listing securities, options, futures, commodities, foreign exchange and other financial instruments. 1. An embedded risk assessment system , comprising:a surface;two or more personality modules each installed on the surface and electrically connected to each other, the two or more personality modules being one or more programmable logic devices;the two or more personality modules being selected from a group consisting of a client personality module, a market participant personality module, a liquidity venue personality module and a market data personality module; andthe two or more personality modules collectively performing pre-trade risk assessment for a client with reduced latency.2. The system of claim 1 , wherein the two or more personality modules are the client personality module claim 1 , the liquidity venue personality module and the market data personality module claim 1 , the client personality module having a set of risk data for a particular client claim 1 , the liquidity venue personality module allowing the client personality module to interact with the liquidity venue to send a trade and receive notifications of a completed trade and the market data personality module gathering data about a particular market and wherein the client personality module and the liquidity venue personality module perform pre-trade risk assessment for the client with reduced latency.3. The system of claim 1 , wherein the two or more personality modules are the client personality module and the liquidity venue personality module claim 1 , the client personality module having a set of risk data for a ...

INFLATABLE SWIM VEST

An inflatable swim vest is constructed with a first layer and a second layer having respective outer edges variously secured together by fixtures to define a compartment therebetween. An inflatable bladder arrangement includes an inflatable bladder stored and housed in a deflated condition in separate areas of the compartment. The inflatable bladder arrangement further includes an inflator mechanism operatively connected to a charged gas canister and to the inflatable bladder. The fixtures securing the outer edges of the first and second layers include a temporary closure configured for temporarily affixing the outer edges together and to be easily separable such that upon actuation of the inflator mechanism, gas is delivered to the inflatable bladder. This results in an inflated condition of the bladder, and produces a force that will open the temporary closure and enable expansion of the bladder out of the compartment of the vest. 1. An inflatable personal flotation device comprising:a vest having at least a front portion connected to a back portion, the front and back portions being adapted to be secured around a torso of a user, the vest being constructed with a first layer and a second layer having respective outer edges variously secured by fixtures to define a compartment between the first layer and the second layer; andan inflatable bladder arrangement including an inflatable bladder stored and housed in a deflated condition in the compartment formed between the first layer and the second layer, the inflatable bladder arrangement further including an inflator mechanism operatively connected to a charged gas canister and to the inflatable bladder,wherein the fixtures securing the outer edges of the first layer arid the second layer together to form the compartment for housing the inflatable bladder therein include a temporary closure configured for temporarily affixing the outer edges together and to be easily separable such that upon actuation of the ...

SYSTEM AND METHOD FOR MANAGEMENT OF UNIQUE ALPHA-NUMERIC ORDER MESSAGE IDENTIFIERS WITHIN DDR MEMORY SPACE

An embedded hardware-based risk system is provided that has an apparatus and method for the management of unique alpha-numeric order message identifiers within DDR memory space restrictions. The apparatus provides a new design for assigning orders (CLOrID) to memory and the method thereof specifically with the intention to not impact latency until memory is over 90% full. 1. A data processing system , comprising:a data processor;a memory coupled to the data processor, the memory having a memory portion for storing memory identifiers, the memory portion having a plurality of bins wherein each bin is mapped to a unique reduced identifier that is an identifier that has been hashed and truncated, each bin having a plurality of bin offsets and each bin offset stores data about the unique reduced identifier associated with the bin wherein the bin offsets allow multiple identifiers to have the same reduced identifier;a hashing unit, associated with the data processor, that selects a bin offset to store each reduced identifier wherein the bin offset is associated with a bin that is associated with the reduced identifier so that multiple identifiers having the same reduced identifier are stored in the memory.2. The system of claim 1 , wherein the memory has a pointer associated with each bin claim 1 , wherein the pointer points to a next available bin offset for each bin claim 1 , and wherein the hashing unit increments the pointer for a bin when a current reduced identifier is stored in the bin.3. The system of claim 2 , wherein the hashing unit stores a next reduced identifier for the bin into the bin offset pointed to by the incremented pointer and increments the pointer for the bin.4. The system of claim 1 , wherein the hashing unit performs a search when each of the bin offsets for a bin are filled for a selected bin and the search is not performed until all of the bin offsets for the bin are full.5. The system of claim 1 , wherein the hashing unit is incorporated into ...

COMPOSITION OF MATTER AND USE THEREOF

Embodiments of the disclosure pertain to a composition of matter having a matrix, a thickener, a strengthener, and a soluble medium. The matrix may be about 100 parts by weight of a low viscosity cycloaliphatic epoxy resin with an anhydride curing agent. The thickener may be about 10-20 parts by weight of an additive comprising a clay. The strengthener may be about 5-10 parts by weight of a glass. The soluble medium may be about 20-30 parts by weight of a water-soluble fiber. 1. A composition of matter comprising:an epoxy system comprising an epoxy resin and a hardener;an additive comprising a clay;a soluble medium; anda glass.2. The composition of claim 1 , wherein the soluble medium comprises a plurality of soluble fibers claim 1 , wherein the clay comprises modified montmorillonite claim 1 , wherein the glass comprises high-strength claim 1 , hollow glass microspheres with an average diameter of about 20 to about 25 microns claim 1 , and wherein the hardener comprises an anhydride.3. The composition of claim 2 , wherein the plurality of soluble fibers comprises sodium polyacrylate fibers claim 2 , and the length is in the range of about 0.5 mm to about 2 mm.4. The composition of claim 1 , wherein the epoxy system comprises about 100 parts by weight claim 1 , wherein the epoxy resin comprises a low viscosity cycloaliphatic epoxy resin claim 1 , wherein the hardener comprises an anhydride curing agent claim 1 , wherein the additive comprises about 10-20 parts by weight claim 1 , wherein the soluble medium comprises about 20-30 parts by weight claim 1 , and further comprises a plurality of water-soluble fibers claim 1 , wherein the glass comprises about 5-10 parts by weight claim 1 , and wherein the glass comprises hollow glass spheres.5. The composition of claim 4 , wherein the clay comprises modified montmorillonite claim 4 , wherein the hollow glass microspheres comprise an average diameter of about 20 to about 25 microns claim 4 , wherein the plurality of ...

Close-cell structured stent, a preparation method and use thereof

Disclosed herein is a close-cell structured stent which is composed of curved struts that intersect at a crossing angle of 90 to 170 degrees in the longitudinal direction. Methods for making the stent, use of the stent as a vascular stent, an esophagus stent, an intestine stent, a bile conduct stent, or a urinary tract stent, and use of the stent in the manufacture of stent graft for the treatment of abdominal aortic aneurysms are also provided. The stent has both excellent longitudinal flexibility and radial strength.

Coated building panels

Described herein is a coated building panel comprising an acoustical body comprising a first major surface and a side surface that intersects the first major surface, a coating applied to the first major surface, the coating comprising a polymeric binder, a pigment, and a hydrophobic component present in an amount ranging from about 1.0 wt. % to about 8.0 wt. % based on the total weight of the coating; and wherein the pigment and polymeric binder are present in a weight ratio ranging from about 3.5:1 to about 6.5:1.

SYNTHESIS OF ECHINOCANDIN ANTIFUNGAL AGENT

The present invention relates to echinocandin cyclopeptides and to methods for preparing echinocandin cyclopeptides. 2. The method of claim 1 , wherein the concentration of the mixture is at least 0.01 moles per L relative to the compound of formula (I).3. The method of or claim 1 , wherein step (c) comprises forming a mixture in a solvent system comprising a mixture of tetrahydrofuran and acetonitrile.4. The method of any one of - claim 1 , wherein step (c) comprises forming a mixture comprising at least 10 molar equivalents of the salt of choline and at least 1 molar equivalents of the boronate ester of anidulafungin.5. The method of any one of - claim 1 , wherein step (c) is performed at a temperature of less than 40° C.6. The method of any one of - claim 1 , wherein step (c) comprises forming a mixture in which at least 50% of the compound of formula (I) is precipitated.7. The method of any one of - claim 1 , wherein R is C-Caryl.8. The method of any one of - claim 1 , wherein R is substituted or unsubstituted Caryl.9. The method of any one of - claim 1 , wherein R is C-Calkyl.11. The method of claim 10 , wherein Ar is selected from phenyl claim 10 , 3 claim 10 ,4-dimethoxyphenyl claim 10 , 2 claim 10 ,6-dimethylphenyl claim 10 , and 4-trifluoromethylphenyl.12. The method of or claim 10 , wherein Ar is 3 claim 10 ,4-dimethoxyphenyl.13. The method of or claim 10 , wherein Ar is 2 claim 10 ,6-dimethylphenyl.14. The method of or claim 10 , wherein Ar is 4-trifluoromethylphenyl.15. The method of claim 10 , wherein step (c) comprises combining at least 10 molar equivalents of the salt of choline with at least 1 molar equivalents of the boronate ester of anidulafungin.16. The method of any one of - claim 10 , wherein the first composition comprises a solution of the boronate ester of anidulafungin dissolved in an organic solvent selected from acetonitrile claim 10 , butyronitrile claim 10 , tetrahydrofuran claim 10 , or 2-methyltetrahydrofuran claim 10 , or a mixture ...

Uterine Manipulator

A uterine manipulator device includes: an elongated cannulated tube comprising a proximal end and a distal end; a cervical cup having a top proximal portion of a first diameter and a base distal portion of a second smaller diameter, wherein: the base distal portion includes a hole formed therein having a perimeter including a distal end and a proximal end, and including a longitudinal axis positioned therethrough; one of the proximal end of the perimeter and the distal end of the perimeter is angled away from the longitudinal axis and the other of the proximal end of the perimeter and the distal end of the perimeter is in line with the longitudinal axis; and the elongated cannulated tube is positioned through the hole in the cervical cup. 1. A uterine manipulator device comprising:an elongated cannulated tube comprising a proximal end and a distal end; the base distal portion includes a hole formed therein having a perimeter including a distal end and a proximal end, and including a longitudinal axis positioned therethrough;', 'one of the proximal end of the perimeter and the distal end of the perimeter is angled away from the longitudinal axis and the other of the proximal end of the perimeter and the distal end of the perimeter is in line with the longitudinal axis; and', 'the elongated cannulated tube is positioned through the hole in the cervical cup., 'a cervical cup having a top proximal portion of a first diameter and a base distal portion of a second smaller diameter, wherein2. The device of claim 1 , wherein the proximal end of the elongated cannulated tube is nonlinear.3. The device of claim 1 , further comprising a vaginal cup positioned distally from the cervical cup on the elongated cannulated tube claim 1 , wherein the vaginal cup includes a top distal portion with a first diameter and a base proximal portion with a second smaller diameter claim 1 , and wherein the vaginal cup is configured to maintain pneumoperitoneum during use.4. The device of claim ...

Systems and methods for providing real-time pre-trade risk assessment

Systems and methods are disclosed that provide real-time pre-trade risk assessments for multiple parties. In one embodiment, a Programmable Logic Device (PLD) may be embedded within an Automated Trading Systems (ATS) architecture by utilizing the Intel socket G or the PCIe interface to provide pre-trade risk functionality. The system may also provide a method for interacting with the ATS DRAM or L1 cache to provide faster access to orders in ATS memory for PLDs. The system may use the Quick Path Interconnect between an embedded processor and a PLD to transfer memory maps. The system may also add additional libraries to an ATS processor to accelerate the transfer or memory maps to a PLD. The system also may use system interrupts to cancel erroneous orders within an ATS processor from a PLD housed within the same physical architecture.

SYSTEMS AND METHODS FOR PROVIDING REAL-TIME PRE-TRADE RISK ASSESSMENT

Systems and methods are disclosed that provide real-time pre-trade risk assessments for multiple parties. In one embodiment, a Programmable Logic Device (PLD) may be embedded within an Automated Trading Systems (ATS) architecture by utilizing the Intel socket G or the PCIe interface to provide pre-trade risk functionality. The system may also provide a method for interacting with the ATS DRAM or L1 cache to provide faster access to orders in ATS memory for PLDs. The system may use the Quick Path Interconnect between an embedded processor and a PLD to transfer memory maps. The system may also add additional libraries to an ATS processor to accelerate the transfer or memory maps to a PLD. The system also may use system interrupts to cancel erroneous orders within an ATS processor from a PLD housed within the same physical architecture. 1. A system comprising:a first memory;an API; receive market data information;', 'write market order information based on the market data information;', 'pass the market order information to the API:', 'using the API, determine a first location on the first memory to place the market order information based on a standard format; and', 'using the API, place the market order information in the first location; and, 'an automated trading system (ATS) processor configured to determine the first location based on the standard format; and', 'obtain the market order information based on the first location., 'a trade risk processor in communication with the ATS processor configured to2. The system of claim 1 , wherein a shadow map of at least a portion of the first memory within a memory space of the trade risk processor is created by the API claim 1 , andwherein the ATS processor is further configured to update the shadow map based on the writing of the market order information in the first memory.3. The system of claim 1 , wherein the trade risk processor is further configured to:determine whether the market order information satisfies one or ...

EMBEDDED HARDWARE BASED SYSTEM WHICH PROVIDES REAL-TIME PRE-TRADE RISK ASSESSMENTS FOR MULTIPLE PARTIES AND METHOD THEREOF

A risk assessment system and method are provided that may be implemented as an embedded hardware based system and method that provide real-time pre-trade risk assessments for multiple parties, in addition to real-time market data and trading connectivity to a variety of liquidity venues. The liquidity venues may include regulated exchanges, ECNs and other financial institutions listing securities, options, futures, commodities, foreign exchange and other financial instruments. 1. An embedded risk assessment system , comprising:a printed circuit board; and the one or more personality modules are configured to collectively perform pre-trade risk assessment for a client,', 'the one or more personality modules comprise a client personality module,', 'the client personality module comprises a set of risk criteria for the client and is configured to forward a trade order for the client to a liquidity venue if the trade order satisfies the set of risk criteria; and', 'the client personality module updates a risk profile of the client in real-time without reliance on order acknowledgements from the liquidity venue, wherein the updates to the risk profile are performed based on an assumption that all orders transmitted to the liquidity venue are completed even if order acknowledgements have not yet been received for the orders from the liquidity venue., 'one or more programmable logic devices installed on the printed circuit board in electronic communication with each other, the one or more programmable logic devices comprising one or more personality modules, wherein'}2. The embedded risk assessment system of claim 1 , wherein the client personality module permits transmission of subsequent orders by the client to the liquidity venue based on the risk profile of the client even if order acknowledgements have not yet been received for previous orders transmitted to the liquidity venue.3. The embedded risk assessment system of claim 1 , wherein the one or more personality ...

Single cell analyses

This disclosure describes improvements to both hardware and enzymatic reactions used in single cell analyses such as but not limited to Seq-well that enable significant increases in the yield of transcripts per cell, improved portability and ease of use, increased scalability of the assay, and linkage of transcript information to other measurements made in the picowell arrays.

Selective Estrogen Receptor Down-Regulators

and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of cell proliferative disorders.

DOWNHOLE TOOL WITH BOTTOM COMPOSITE SLIP

A downhole tool having a mandrel, and a bottom slip disposed around the mandrel. The bottom slip includes a circular body having a one-piece configuration characterized by a plurality of slip segments by at least partial material connectivity therearound. The bottom slip is made of a filament wound composite material, which means the bottom slip has a plurality of layers joined by respective interface layers. An outer slip surface of at least one of the plurality of slip segments is defined in cross-section by a plane P that intersects a longitudinal axis of the downhole tool at an angle a when the bottom slip is in an unset position. 1. A downhole tool comprising:a mandrel; a circular body having a plurality of slip segments connected by a one-piece configuration characterized by at least partial material connectivity therearound,', {'b': '1', 'wherein the bottom slip is made of a filament wound composite material further comprising a plurality of layers joined by respective interface layers, wherein an outer slip surface of an at least one of the plurality of slip segments is defined in cross-section by a plane P that intersects a longitudinal axis of the downhole tool at an angle a when the bottom slip is in an unset position, and wherein an end of the at least one of the plurality of slip segments further comprises a facet; and'}], 'a bottom slip disposed around the mandrel, and further comprising{'b': '1', 'a bottom cone having an end face proximately engaged with the facet of the bottom slip at a break angle b defined in cross-section by a break plane B that intersects the longitudinal axis,'}{'b': 1', '1, 'wherein the bottom cone has a sloped outer surface defined in cross-section by a plane P′ that respectively intersects the longitudinal axis at an angle a′ that is oriented in an opposite direction to the angle a, and wherein the sloped outer surface is not engaged with an inner slip surface in the unset position.'}2. The downhole tool of claim 1 , wherein ...

Quick coupler

This invention related to a coupler for securing an attachment to an earth working machine. The coupler comprises a coupler body that presents a receptacle having a capture region. A pin of an attachment can move into and out of the capture region. A retainer can capture the pin in the capture region but the retainer can be moved by a hydraulically driven driver to a position to allow release the pin from the capture region. A trigger that the pin will strike when the pin moves into or out of the capture region, decouples the driver from the retainer and the retainer is then allowed to be biased back to its retaining position by a spring.

COMPOSITIONS AND METHODS FOR THE TREATMENT OF FUNGAL INFECTIONS

The disclosure features non-irritating pharmaceutical compositions containing CD101 in pharmaceutical acceptable salt (e.g., CD101 acetate) or neutral form. The pharmaceutical compositions can be intravenously administered to a subject to treat fungal infections (e.g., candidiasis) in the subject. 1. A pharmaceutical composition for intravenous injection comprising an aqueous solution comprising at least 85% (w/w) water , between 0.4 mg/mL and 10 mg/mL CD101 , and an intravenous solubility promoter ,wherein the weight to weight (w/w) ratio of the intravenous solubility promoter to the CD101 in the pharmaceutical composition is at least 2,the CD101 is in its salt or neutral form;the pharmaceutical composition has a pH of between 5 and 7, andthe pharmaceutical composition exhibits reduced local irritation upon intravenous administration to a subject.2. The pharmaceutical composition of claim 1 , wherein the w/w ratio of the intravenous solubility promoter to the CD101 in the pharmaceutical composition is between 2 and 8.3. The pharmaceutical composition of or claim 1 , wherein the intravenous solubility promoter is selected from the group consisting of polysorbate 20 (Tween 20; polyoxyethylene (20) sorbitan monolaurate) claim 1 , polysorbate 40 (Tween40; polyoxyethylene (40) sorbitan monopalmitate) claim 1 , polysorbate 60 (Tween 60; polyoxyethylene (60) sorbitan monostearate) claim 1 , polysorbate 80 (Tween 80; polyoxyethylene (80) sorbitan monooleate) claim 1 , β-cyclodextrin claim 1 , polyoxyl 35 castor oil (Cremophor EL) claim 1 , polyoxyl 40 hydrogenated castor oil (Cremophor RH 40) claim 1 , polyoxyl 60 hydrogenated castor oil (Cremophor RH 60) claim 1 , D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) claim 1 , sorbitan monooleate (Span 20) claim 1 , polyoxyl 8 stearate (PEG 400 monosterate) claim 1 , polyoxyl 40 stearate (PEG 1750 monosterate) claim 1 , PEG 400 caprylic/capric glycerides (Labrasol) claim 1 , PEG 300 oleic glycerides (Labrafil M-1944CS) ...

ULTRASOUND TRANSDUCER

A method for producing a plurality of piezoelectric ultrasound transducer elements, the method comprising providing or depositing a piezoelectric material on at least part of a surface of a sheet of substrate to form a layered member; and forming the one or more piezoelectric ultrasound transducer elements from the layered member. 148-. (canceled)49. A method for producing a plurality of piezoelectric ultrasound transducer elements , the method comprising the steps of:providing or depositing a piezoelectric material on at least part of a surface of a sheet of substrate to form a layered member; andforming the one or more piezoelectric ultrasound transducer elements from the layered member.50. The method of claim 49 , wherein the piezoelectric material is arranged or deposited on at least the part of the surface of the substrate so as to cover at least a majority or all of the surface of the sheet of substrate.51. The method of claim 49 , further comprising one or more of the steps of:at least one of cutting, stamping, releasing or otherwise forming one or preferably a plurality of shaped portions from the layered member, the shaped portions forming the transducer elements or blanks for producing the transducer elements therefrom; andproviding or depositing a layer of dielectric material onto at least some or all of a surface of the piezoelectric material.52. The method of claim 49 , wherein the shaped portions comprise an active part and at least one tab protruding from the active part and the method comprises bending the tab relative to the active part claim 49 , so that the tab is angled relative to the active part.53. The method of claim 49 , wherein the piezoelectric material is at least one of:an inorganic, crystalline, polycrystalline or non-polymeric material; orin a continuous layer of material having piezoelectric properties in which the piezoelectric material does not comprise discrete domains of piezoelectric material within a matrix of non-piezoelectric ...

Method and apparatus for evaluating the quality of characteristics of motion of an animal-human-dyad

The invention relates to method for evaluating the quality of characteristics of motion of an animal-human-dyad comprising an animal and a human and using at least one rein for riding the animal, wherein the quality of characteristics of motion is the loss of regularity of rhythm in the motion of the animal, the method comprising obtaining rein tension data indicating the tension in the rein (10) by means of a rein tension measuring device (20), wherein the the following steps are executed by a processing unit (90): processing the rein tension data into a frequency spectrum; identifying a prominent frequency component in the frequency spectrum; analysing the frequency spectrum by determining a power spectral density of the frequency spectrum over a frequency range which contains the prominent frequency component; and evaluating the loss of regularity of rhythm in the motion by comparing the determined power spectral density with a reference value. Further, the invention relates to an apparatus for evaluating the quality of characteristics of motion of an animal-human-dyad, wherein the apparatus comprises a rein tension measuring device, a transmitter unit, a receiving unit, a processing unit and a notification unit.

DOWNHOLE TOOL WITH BOTTOM COMPOSITE SLIP

A downhole tool having a mandrel, and a bottom slip disposed around the mandrel. The bottom slip includes a circular body having a one-piece configuration characterized by a plurality of slip segments by at least partial material connectivity therearound. The bottom slip is made of a filament wound composite material, which means the bottom slip has a plurality of layers joined by respective interface layers. An outer slip surface of at least one of the plurality of slip segments is defined in cross-section by a plane P that intersects a longitudinal axis of the downhole tool at an angle a in a range of degrees to degrees when the bottom slip is in an unset position. 1. A downhole tool comprising:a mandrel; a circular body having a plurality of slip segments connected by a one-piece configuration characterized by at least partial material connectivity therearound,', {'b': '1', 'wherein the bottom slip is made of a filament wound composite material further comprising a plurality of layers joined by respective interface layers, wherein an outer slip surface of an at least one of the plurality of slip segments is defined in cross-section by a plane P that intersects a longitudinal axis of the downhole tool at an angle a in a range of 10 degrees to 20 degrees when the bottom slip is in an unset position, and wherein an end of the at least one of the plurality of slip segments further comprises a facet; and'}], 'a bottom slip disposed around the mandrel, and further comprising{'b': '1', 'a bottom cone having an end face proximately engaged with the facet of the bottom slip at a break angle b defined in cross-section by a break plane P′ that intersects the longitudinal axis in a range of 20 degrees to 60 degrees.'}2120. The downhole tool of claim 1 , wherein each of the plurality of slip segments has an inclined outer surface defined in cross-section by a respective plane P that intersects a longitudinal axis of the downhole tool at a respective angle a in a range of 10 ...

SYSTEMS AND METHODS FOR PROVIDING REAL-TIME PRE-TRADE RISK ASSESSMENT

Systems and methods are disclosed that provide real-time pre-trade risk assessments for multiple parties. In one embodiment, systems and methods can be configured to receive a market order data packet, wherein the market order data packet comprises order information for a market order to be made at a liquidity venue. The market order data packet comprises a header portion and a payload portion, and the header portion comprises at least a portion of the order information. An order symbol is determined based on order symbol information in the header portion. Risk parameters are retrieved associated with the order symbol. It is determined whether or not a risk threshold is exceeded based on the risk parameters and the order information. A final market order data packet is generated for transmission to the liquidity venue based on the determining whether the risk threshold is exceeded. 1. A computer-implemented method comprising:receiving, by a computing system, a market order data packet, whereinthe market order data packet comprises order information for a market order to be made at a liquidity venue,the market order data packet comprises a header portion and a payload portion, andthe header portion comprises at least a portion of the order information, wherein the order information in the header portion comprises at least an order symbol information;determining, by the computing system, an order symbol based on the order symbol information in the header portion;retrieving, by the computing system, risk parameters associated with the order symbol;determining, by the computing system, whether a risk threshold is exceeded based on the risk parameters and the order information; andgenerating, by the computing system, a final market order data packet for transmission to the liquidity venue based on the determining whether the risk threshold is exceeded.2. The computer-implemented method of claim 1 , whereinthe header portion comprises an assigned Media Access Control (MAC ...

DOWNHOLE TOOL WITH TETHERED BALL

A downhole tool having a mandrel, a first slip, a second slip, a lower sleeve, and a tethered ball assembly. The mandrel includes a proximate end; a distal end; a bore having a ball seat associated therewith; and an outer surface. The first slip is disposed around the mandrel. The second slip is disposed around the mandrel. The lower sleeve is proximate to the first slip, and engaged with the outer surface at the distal end. The tethered ball assembly includes a ball; a drag; and at least one tether coupled between the ball and the drag. 1. A downhole tool comprising:a mandrel configured with a bore and a ball seat; a ball;', 'a drag;', 'at least one tether coupled between the ball and the drag; and', 'a retainer,, 'a tethered ball assembly comprisingwherein the retainer is coupled to the downhole tool in a manner whereby the ball is free to move off the ball seat only so far as the tether permits.2. The downhole tool of claim 1 , wherein a second tether is coupled between the retainer and the drag.3. The downhole tool of claim 2 , wherein the drag is spherical.4. The downhole tool of claim 3 , wherein the downhole tool is a frac plug.5. The downhole tool of claim 4 , wherein at least one component of the downhole tool is made of a reactive material.6. The downhole tool of claim 4 , wherein at least one component of the tethered ball assembly is made of a reactive material.7. A downhole tool comprising: a proximate end;', 'a distal end;', 'a bore having a ball seat associated therewith; and', 'an outer surface;, 'a mandrel comprisinga first slip disposed around the mandrel;a second slip disposed around the mandrel;a lower sleeve proximate to the first slip, and engaged with the outer surface at the distal end; a ball;', 'a drag; and', 'at least one tether coupled between the ball and the drag., 'a tethered ball assembly comprising8. The downhole tool of claim 7 , wherein the tethered ball assembly further comprises a retainer claim 7 , and wherein a second tether is ...

Uterine Manipulator

A uterine manipulator device includes: an elongated cannulated tube comprising a proximal end and a distal end; a cervical cup having a top proximal portion of a first diameter and a base distal portion of a second smaller diameter, wherein: the base distal portion includes a hole formed therein having a perimeter including a distal end and a proximal end, and including a longitudinal axis positioned therethrough; one of the proximal end of the perimeter and the distal end of the perimeter is angled away from the longitudinal axis and the other of the proximal end of the perimeter and the distal end of the perimeter is in line with the longitudinal axis; and the elongated cannulated tube is positioned through the hole in the cervical cup. 1. A uterine manipulator device comprising:an elongated cannulated tube comprising a proximal end and a distal end; the base distal portion includes a hole formed therein having a perimeter including a distal end and a proximal end, and including a longitudinal axis positioned therethrough;', 'one of the proximal end of the perimeter and the distal end of the perimeter is angled away from the longitudinal axis and the other of the proximal end of the perimeter and the distal end of the perimeter is in line with the longitudinal axis; and', 'the elongated cannulated tube is positioned through the hole in the cervical cup., 'a cervical cup having a top proximal portion of a first diameter and a base distal portion of a second smaller diameter, wherein2. The device of claim 1 , wherein the proximal end of the elongated cannulated tube is nonlinear.3. The device of claim 1 , further comprising a vaginal cup positioned distally from the cervical cup on the elongated cannulated tube claim 1 , wherein the vaginal cup includes a top distal portion with a first diameter and a base proximal portion with a second smaller diameter claim 1 , and wherein the vaginal cup is configured to maintain pneumoperitoneum during use.4. The device of claim ...

System and Method for Recommendation of Content Based on Mood and Other External Factors

A method includes receiving a request for a recommendation for content, wherein the request includes an indication of a user's mood, responsive to the receiving request, accessing a user profile, characterizing upcoming content by assigning at least one attribute to the content, generating the recommendation based on the user profile, the user's mood and the at least one attribute. 1. A method comprising:Suggesting, by a server, one of a plurality of moods of a user based on data from an extrinsic source;Receiving, by a server, a request for a recommendation for content, wherein said request includes a confirmation of the one of a plurality of moods of the user is indicative of the user's current mood;responsive to the receiving request, the server retrieving a user profile;characterizing, by the server, upcoming content by assigning at least one attribute to the content; andgenerating, by the server, the recommendation based on the user profile, the user's current mood and the at least one attribute.2. The method of further comprising receiving claim 1 , by the server claim 1 , an indication of activity associated with the request and wherein the recommendation is further based on the indication of activity.3. The method of further comprising receiving claim 1 , by the server claim 1 , a preference of genre associated with the request and wherein the recommendation is further based on the preference of genre.4. The method of wherein the request applies to a first time period and the recommendation is based on content available during the first time period.5. The method of further comprising receiving a second request wherein the second request applies to a second time period and wherein the generating step comprises generating a first recommendation for the first time period and a second recommendation for the second time period wherein the first recommendation and the second recommendation is based at least in part on the request an indication of the user's mood ...

A locking device for a quick coupler

A wedge locking element ( 10 ) for a locking device of a quick coupler A for coupling the pin P 2 of an attachment to earth working machinery. The wedge locking element ( 10 ) has a sloping wedge surface ( 13 ). Projecting from the wedge surface ( 13 ) is an engagement surface ( 12 ) with which the attachment pin P 2 can engage but not apply any substantial driving force to the wedge locking element ( 10 ) in the event of failure of a force maintaining the wedge locking element ( 10 ) in a position where the pin P 2 is retained with the coupler A. The pin engagement surface ( 12 ) lies in a plane that is substantially in line with the direction in which the locking element ( 10 ) is, in use, moved by the driving force.

SYSTEMS AND METHODS FOR PROVIDING REAL-TIME PRE-TRADE RISK ASSESSMENT

Systems and methods are disclosed that provide real-time pre-trade risk assessments for multiple parties. In one embodiment, a Programmable Logic Device (PLD) may be embedded within an Automated Trading Systems (ATS) architecture by utilizing the Intel socket G or the PCIe interface to provide pre-trade risk functionality. The system may also provide a method for interacting with the ATS DRAM or L1 cache to provide faster access to orders in ATS memory for PLDs. The system may use the Quick Path Interconnect between an embedded processor and a PLD to transfer memory maps. The system may also add additional libraries to an ATS processor to accelerate the transfer or memory maps to a PLD. The system also may use system interrupts to cancel erroneous orders within an ATS processor from a PLD housed within the same physical architecture. 1. A system comprising:a first memory;a shadow map of the first memory; receive market data information,', 'write market order information to the first memory based on the market data information,', 'update the shadow map based on the market order information written to the first memory, and', 'prepare a market order for transmission to a market venue based on the market order information; and, 'an automated trading system (ATS) processor in communication with the first memory and the shadow map, the ATS processor configured to'} obtain the market order information from the shadow map, and', 'performance of the trade risk assessment and preparation of the market order are simultaneous.', 'perform a trade risk assessment based on the market order information obtained from the shadow map, wherein'}], 'a trade risk processor in communication with the ATS processor, the trade risk processor configured to'}2. The system of claim 1 , wherein the trade risk processor is in communication with the ATS processor via a PCIe connection.3. The system of claim 2 , wherein the first memory comprises a dynamic random access memory.4. The system of ...

LIVER INFECTION

The invention relates to a method for studying an infection process in liver tissue in vitro, the method comprising: seeding hepatocyte cells onto a scaffold in a bioreactor in order to form a liver tissue model;delivering an infectious agent to the liver tissue model, or providing the liver tissue model pre-infected with an infectious agent; and monitoring the infection process; and a method for producing an infectious agent. 1. A method for studying an infection process in liver tissue in vitro , the method comprising:seeding hepatocyte cells onto a scaffold in a bioreactor in order to form a liver tissue model;delivering an infectious agent to the liver tissue model, or providing the liver tissue model pre-infected with an infectious agent; andmonitoring the infection process.2. The method according to claim 1 , wherein between about 0.4×10and about 1×10cells per scaffold are seeded at a flow rate through the bioreactor of between about 0.5 μl/s and about 2 μl/s.34.-. (canceled)5. The method according to claim 1 , wherein the liver tissue model produces or is capable of producing between 1000 and 100 claim 1 ,000 TCID50/mL infectious agent per 48 hours.68.-. (canceled)9. The method according to claim 1 , wherein the infectious agent is delivered in a quantity of at least about 0.01 m.o.i (multiplicity of infection); orwherein the infectious agent is delivered in a quantity of at least about 1e4 per ml.1011.-. (canceled)12. The method according to claim 1 , further comprising seeding additional cells with the hepatocytes claim 1 , wherein the additional cells are non-parenchymal liver cells.1323.-. (canceled)24. The method according to claim 1 , wherein the infectious agent is a hepatitis virus.2527.-. (canceled)28. The method according to claim 1 , wherein the bioreactor comprises a bioreactor well comprising the scaffold disposed therein.29. The method according to claim 1 , wherein the bioreactor comprises a fluid reservoir fluidly connected to the bioreactor ...

SYSTEMS AND METHODS FOR PROVIDING REAL-TIME PRE-TRADE RISK ASSESSMENT

Systems and methods are disclosed that provide real-time pre-trade risk assessments for multiple parties. In one embodiment, systems and methods can be configured to receive a market order data packet, wherein the market order data packet comprises order information for a market order to be made at a liquidity venue. The market order data packet comprises a header portion and a payload portion, and the header portion comprises at least a portion of the order information. An order symbol is determined based on order symbol information in the header portion. Risk parameters are retrieved associated with the order symbol. It is determined whether or not a risk threshold is exceeded based on the risk parameters and the order information. A final market order data packet is generated for transmission to the liquidity venue based on the determining whether the risk threshold is exceeded. 1. A computer-implemented method comprising: the market order data packet comprises order information for a market order to be made at a liquidity venue,', 'the market order data packet comprises a header portion and a payload portion, and', 'the header portion comprises at least a portion of the order information, wherein the order information in the header portion comprises at least an order symbol information;, 'receiving, by a computing system, a market order data packet, wherein'}determining, by the computing system, an order symbol based on the order symbol information in the header portion;retrieving, by the computing system, risk parameters associated with the order symbol;determining, by the computing system, whether a risk threshold is exceeded based on the risk parameters and the order information; andgenerating, by the computing system, a final market order data packet for transmission to the liquidity venue based on the determining whether the risk threshold is exceeded.2. The computer-implemented method of claim 1 , whereinthe header portion comprises an assigned Media ...

ULTRASOUND ARRAY TRANSDUCER MANUFACTURING

Described herein is a method for manufacturing, or for use in manufacturing a flexible ultrasonic transducer array and the resultant ultrasonic transducer array. The method includes providing a layer of piezoelectric material onto a foil substrate and using additive techniques to apply at least one electrode to a surface of the piezoelectric material such that the electrodes are arranged in an electrode array. The method also includes using the additive techniques to applying a plurality of electrical conduction tracks and a plurality of electrical connectors to the surface of the piezoelectric material or to a layer of dielectric material provided on the surface of the piezoelectric material, such that respective electrical conduction tracks electrically connect a respective electrode to a respective electrical connector. The additive techniques comprise at least one of: masking, deposition, photo patterning, printing or patterned coating. Optionally layer of piezoelectric material comprises a layer of inorganic piezoelectric material that has been deposited onto the foil. 1. A method for manufacturing , or for use in manufacturing , a flexible ultrasonic transducer for imaging and non-destructive testing , the method comprising:providing a layer of piezoelectric material on a foil substrate;using additive techniques to apply a plurality of electrodes to a surface of the piezoelectric material and to apply a plurality of electrical conduction tracks and a plurality of electrical connectors to the surface of the piezoelectric material or to a layer of dielectric material provided on the surface of the piezoelectric material, wherein the electrodes are arranged in an electrode array, and respective electrical conduction tracks electrically connect a respective electrode to a respective electrical connector;wherein the additive techniques comprise at least one of: masking, deposition, photo patterning, printing or patterned coating.2. The method of in which at least ...

FORMATION OF PIEZOELECTRIC DEVICES

A method for producing an ultrasonic transducer or ultrasonic transducer array, the method comprising providing or depositing a layer of piezoelectric material on a substrate. The piezoelectric material is a doped, co-deposited or alloyed piezoelectric material. The piezoelectric material comprises: a doped, co-deposited or alloyed metal oxide or metal nitride, the metal oxide or metal nitride being doped, co-deposited or alloyed with vanadium or a compound thereof; or zinc oxide doped, co-deposited or alloyed with a transition metal or a compound thereof. Optionally, the deposition of the layer of piezoelectric material is by sputter coating, e.g. using a sputtering target that comprises a doped or alloyed piezoelectric material. In examples, the layer of piezoelectric material is deposited onto the substrate using high power impulse magnetron sputtering (HIPIMS). Further enhancement may be obtained using substrate biasing (e.g. DC and/or RF) during deposition of the layer of piezoelectric material. In further examples, the substrate is provided on a rotating drum whilst tire layer of piezoelectric material is being deposited. 1. A method for producing an ultrasound transducer or ultrasonic transducer array for imaging , measurement or non-destructive testing , the method comprising:providing or depositing a layer of piezoelectric material on a substrate; wherein the piezoelectric material is a doped, co-deposited or alloyed piezoelectric material; and the piezoelectric material comprises:a doped, co-deposited or alloyed metal oxide or metal nitride, the metal oxide or metal nitride being doped, co-deposited or alloyed with vanadium or a compound thereof; or zinc oxide doped, co-deposited or alloyed with a transition metal or a compound thereof.2. The method of claim 1 , wherein the deposition of the layer of piezoelectric material is by sputter coating using a sputtering target that comprises a doped or alloyed piezoelectric material.3. (canceled)4. The method of ...

Methods and compositions for modulating microenvironment

Methods and compositions for treating or preventing a disease by modulating a microenvironment of a cell or cell mass in a subject, the method comprising administrating an effective amount of one or more modulating agents that modulate mast cells, plasma cells, Th1-Th17 cells, and/or CD8+ T cells in the subject.

Stabilization of antimicrobial coatings

Described herein is a coated building panel comprising: a substrate comprising a first major surface opposite a second major surface; a coating atop at least one of the first major surface or the second major surface, the coating comprising: a binder composition; an antimicrobial composition comprising a cationic compound; a stabilization composition comprising: a silicate compound; and a surfactant having an HLB value between about 10 and about 14.

Composition of matter and use thereof.

Las realizaciones de la divulgación se refieren a una composición de materia que tiene una matriz, un espesante, un fortalecedor y un medio soluble. La matriz puede ser de aproximadamente 100 partes en peso de una resina epoxi cicloalifática de baja viscosidad con un agente curado con anhídrido. El espesante puede ser de aproximadamente 10-20 partes en peso de un aditivo que comprende una arcilla. El reforzante puede ser de aproximadamente 5-10 partes en peso de un vidrio. El medio soluble puede ser de aproximadamente 20-30 partes en peso de una fibra soluble en agua.

Determining entity popularity using search queries

Systems, methods, and computer-readable media for determining the Internet search popularity of an entity are provided. Embodiments of the present invention include receiving a group of Internet search records and assigning a popularity ranking based on the number of times an entity descriptor associated with an entity occurs within the group of Internet search records created over a designated time period. An entity descriptor is one or more terms commonly used to identify an entity. The trend in an entity's popularity rank may also be calculated. An entity's popularity rank and trend in popularity rank may be presented in a graph or in a list.

Vinylic aluminum compounds and process of preparing same

Inhalation device

The present invention relates to an inhalation-activatable device for administration of medicament in powder form to the respiratory system of a patient.

Inhalation device

Un dispositivo activable por inhalación para administración de medicamento en forma de polvo al sistema respiratorio de un usuario que comprende una carcasa (2, 3) que define entradas (23) de aire y una boquilla (22), y una tapa (1) para cubrir la boquilla (22), en el que la carcasa (2, 3) contiene un portador (11) de dosis con medicamento en forma de polvo dispuesto en una pluralidad de unidades de dosis y un mecanismo activado por respiración, que comprende unos medios de almacenamiento de energía, unos medios de accionamiento, unos medios de perforación y unos medios de reinicio, en el que los medios de activación comprenden una aleta (9) de mecanismo activado por respiración (BAM) montado para movimiento entre las posiciones hacia adentro y neutras, la aleta BAM se posiciona lejos de la boquilla (22) y sustancialmente lejos de las entradas (23) de aire con el fin de no cerrar las entradas de aire en su posición neutral o hacia adentro, de tal manera que la inhalación a través de la boquilla (22) provoca movimiento de la aleta (9) BAM hacia su posición hacia adentro, y otros componentes que se pueden mover con relación a la posición de la aleta (9) BAM de tal manera que cuando la aleta (9) BAM está en la posición hacia adentro, se perfora una unidad de dosis de la pluralidad de unidades de dosis en el portador (11) de dosis mediante unos medios de perforación para suministrar el medicamento en forma de polvo a través de la boquilla (22) al sistema respiratorio de la usuario; caracterizado porque el dispositivo activable por inhalación comprende adicionalmente un pasaje de aire, en el que el pasaje de aire comprende un cabezal de ciclón, una región cónica, una región de garganta y palas al final del pasaje de aire. An inhalation-activated device for administration of medicament in powder form to the respiratory system of a user comprising a housing (2, 3) defining air inlets (23) and a mouthpiece (22), and a cover (1) for covering the nozzle (22), in which the ...

Inhalation device

The present invention relates to an inhalation-activatable device for administration of medicament in powder form to the respiratory system of a patient.

Inhalation device

The present invention relates to an inhalation-activatable device for administration of medicament in powder form to the respiratory system of a patient.

Inhalation device

Inhalation device

Inhalation device

Inhalation device

The present invention relates to an inhalation-activatable device for administration of medicament in powder form to the respiratory system of a patient.

Inhalation device

The present invention relates to an inhalation-activatable device for administration of medicament in powder form to the respiratory system of a patient.

Aerosol delivery systems, compositions and methods

An aerosol preparation assembly includes an entrainment chamber defining an entrainment volume. The entrainment chamber includes a gas inlet port, an aerosol inlet port and an outlet port. The entrainment chamber is configured such that a velocity of a flow of a gas within the entrainment volume is less than a velocity of the flow of the gas within the gas inlet port. The entrainment chamber is configured such that at least a portion of inlet aerosol is entrained into the flow of the gas within the entrainment volume to produce an entrained aerosol flow at the outlet port. The particle selection chamber is configured to receive the entrained aerosol flow and produce an outlet aerosol flow. The particle selection chamber and nozzle are collectively configured such that a volumetric median diameter of the outlet aerosol flow is less than a volumetric median diameter of the inlet aerosol.

2- (3-ALKYLTIOBENZOIL) CYCLOHEXANODIONS, HERBICIDE PRODUCTS, AND THEIR USE AS HERBICIDES

Composition comprising cis-1,1,1,4,4,4-hexafluoro-2-butene and trans-1,2-dichloroethylene, apparatus containing same and methods of producing cooling therein

A chiller apparatus containing a composition comprising cis-1,1,1,4,4,4-hexafluoro-2-butene and trans-1,2-dichloroethylene.

Phosphate bonded aluminum coatings

A bonding composition for a heat curable overlay coating for coating a substrate is provided. The bonding composition comprises phosphate ions, permanganate ions, at least one species of metal cation having a valence greater than +1, and water. The bonding composition has a pH in the range from about 1.5 to about 4.5 and is substantially free of chromate ions and molybdate ions. Preferably, the molar ratio of phosphate ions to permanganate ions in the bonding composition is in the range from about 2:1 to about 580:1 and the nonvolatile content of the bonding composition is in the range from about 10% (wt) to about 35% (wt). Aluminum ions are a preferred species of metal cation in the bonding composition. Overlay coating compositions are also provided containing metallic aluminum particles dispersed in the bonding composition of the invention.

Hexavalent chromium-free phosphate-bonded coatings

A heat curable bonding composition of the present invention comprises an aqueous solution containing phosphate ion (PO 4 −3 ) and chromium(III) ion (Cr +3 , or trivalent chromium) and is substantially free of hexavalent chromium ions. The bonding composition may further contain at least one secondary cationic species. The bonding composition has a pH in the range of about 1 to about 3.5.

Chromate-free phosphate bonding composition

A heat curable bonding composition for providing a coating to a solid substrate comprises water, phosphate ions, borate ions, and aluminum ions. The bonding composition has a pH in the range from about 1.4 to about 2.2, and is substantially free of chromate ions, molybdate ions, and magnesium ions.

Semi-permeable arrays for analyzing biological systems and methods of using same

The present application provides a method of assembling a container for one or multiple parallel steps of biochemical analysis on one or more cells comprising performing molecular bonding of a porous membrane on an apical or basal surface of an array having a plurality of wells, wherein the molecular bonding substantially isolates each well from adjacent wells.

Lubricant management for an hvacr system

Multiple gas burner unit - comprises metal sheets which are in contact with each other an intervals to form passages between sheets

The unit comprises a number of metal sheets which are so shaped as to be in contact with each other at different intervals over their entire length, so as to form a series of passages (14) between them. Means are provided for delivering a mixture of air and gas to one side of the assembly. From here it flows through the passages and is ignited (15) at the other end. The unit can comprise a number of corrugated sheets alternating with plain or flat sheets or alternatively there can be protrusions on the sheets, between which the passages are formed.

Previewing search results for suggested refinement terms and vertical searches

An embodiment of the current invention is directed to presenting a preview of search results for a suggested search. A search engine query is received. One or more search results are generated. One or more suggested, search terms are generated. A search engine results page is generated, including the one or more search results and the one or more suggested, search terms. An indication is received, indicating that a preview of search results related to a selected, suggested, search term is to be displayed. A preview window including a results section and a menu-bar section is generated. One or more search results related to the selected, suggested, search term are acquired. The one or more search results are presented in the preview window. The preview window allows interaction with the one or more search results.

Cam actuated percussive tool

There is disclosed a tool (5) comprising a cam track (A) and cam follower means (B), wherein a width (WA) of at least a portion of the cam track (A) is greater than a width (WB) of the cam follower means (B). The cam follower means (B) is engaged within the cam track (A), the cam follower means (B) being adapted to run in/ around the cam track (A) and be thrown between opposing walls (D, E) of the cam track (A). In use, the cam follower means (B) therefore has two degrees of motion, a first defined by the cam track (A), and a second defined by ricochet between opposing walls (D, E).

Vehicle for transporting animals

Fsk discriminator

The outputs of two filter channels for accepting two keying frequencies are compared to produce the output. Each channel uses finite impulse response transversal filters; preferably with an impulse response of duration comparable with the symbol period of the incoming signal. Each channel has a pair of filters for accepting phase quadrature components (or, alternatively, quadrature synchronous demodulators followed by filters): the filter coefficients differ from sinusoidal by (or, in the alternative case, are formed by) a modification function which is the same for both filters of the pair.

TETRAZOL-5-IL- AND TRIAZOL-5-YL-ARYL COMPOUNDS AND THEIR USE AS HERBICIDES

COMPOSTOS TETRAZOL-5-IL- E TRIAZOL-5-IL-ARILA E USO DESTES COMO HERBICIDAS. Compostos Tetrazol-5-il- e triazol-5-it-arila de fórmula geral (I) são descritos como herbicidas. Nesta fórmula (I), X, Z, W e R são radicais tais como hidrogênio, radicais orgânicos tais como alquila, e outros radicais tais como halogênio. A e B são N e CY. Q é cianoalquilacarbonila ou isoxazolil. TETRAZOL-5-IL- AND TRIAZOL-5-YL-ARYL COMPOUNDS AND THEIR USE AS HERBICIDES. Tetrazol-5-yl- and triazol-5-it-aryl compounds of general formula (I) are described as herbicides. In this formula (I), X, Z, W and R are radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen. A and B are N and CY. Q is cyanoalkylcarbonyl or isoxazolyl.

Modified biodegradable and medical polymer devices and a method for preparing the same

Improved tool

Disclosed is a tool (5) comprising a cam track (A) and cam follower means (B), wherein the cam track (A) comprises a first cam track wall means (15) and the cam follower (B) comprises a first cam follower wall means (15), and the first cam track wall means (10) and first cam follower wall means (15) face one another. The cam track (A) further comprises a second cam track wall means (30) and the cam follower (B) comprise a second cam follower wall means (35), and the second cam track wall means (30) and second cam follower wall means (35) face one another. The first and second cam track wall means (10, 30) are disposed so as to face one another. The first and second cam follower wall means are disposed so as to oppose one another, e.g. back to back. The first/second cam track wall means (10, 30) comprise a first/second cam track wave (20, 40). The second cam follower wall means (15, 35) comprise a first/second cam follower wave (25, 45).

Improvements in Anti-vibrators for Gas Burners.

18,779. Hughes, H. K. Aug. 16. Incandescent gas burners.-The burner tube of an inverted incandescent gas burner is weighted and provided with a gauze covering 3 over the air inlet. A ring 4 attached to the lower end of the gas pendant carries a guard 17, which prevents the front end of the burner tube from being knocked.

DE-COATING AGENTS AND THEIR APPLICATION FOR DE-COATING RESIST LAYERS OF CARRIERS.

1,2,4-triazine-3,5-dione-6-carboxamides and their use as a herbicide

resumo patente de invenção: "1,2,4-triazina-3,5-diona-6- carboxamidas e uso destas como herbicida ". a presente invenção refere-se a 1,2,4-triazina-3,5-diona-6-carboxamidas da fórmula geral (i) são descritas como herbicidas. nesta fórmula (i), r1 e r2 são radicais tais como hidrogênio, radicais orgânicos tais como alquila, e outros radicais tais como halogênio. q é um radical tetrazolila, triazolila ou oxadiazolila. z e y são respectivamente oxigênio ou enxofre. patent summary: "1,2,4-triazine-3,5-dione-6-carboxamides and their use as a herbicide". The present invention relates to 1,2,4-triazine-3,5-dione-6-carboxamides of the general formula (I) are described as herbicides. In this formula (i), R 1 and R 2 are radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen. q is a tetrazolyl, triazolyl or oxadiazolyl radical. z and y are respectively oxygen or sulfur.

n- (1,3,4-oxadiazol-2-yl) aryl carboxylic acid amides salts and their use as herbicides

sais de amidas de n-(1,3,4-oxadiazol-2-il) aril ácido carboxílico e seu uso como herbicidas sais de n-(1,3,4-oxadiazol-2-il)arilcarboxamidas da fórmula geral (i) são descritos como herbicidas. nesta fórmula (i), x, z e r são radicais, como hidrogênio, radicais orgânicos, como alquil e outros radicais, como halógeno. a é nitrogênio ou carbono. m+ é um cátion. n- (1,3,4-oxadiazol-2-yl) aryl carboxylic acid amides salts and their use as herbicides n- (1,3,4-oxadiazol-2-yl) arylcarboxamides salts of the general formula (i ) are described as herbicides. In this formula (i), x, z and r are radicals such as hydrogen, organic radicals such as alkyl and other radicals such as halogen. a is nitrogen or carbon. m + is a cation.

Flame retardant clear coatings for building panels

Described herein is a barrier coating composition comprising an organic blend comprising a first component and a second component, the first component comprising latex polymer and the second component being selected from polyurethane emulsion, wax emulsion, and alkyd emulsion, wherein the first component and the second component are present in a weight ratio ranging from about 2:1 to about 20:1, and the latex polymer has a glass transition temperature of less than about 18 C.

Hygienic attachments for therapy lasers

Apparatus for handling flexible supply lines

SUPPLY LINE HANDLING APPARATUS FOR A MINING MACHINE CONSISTS OF A TROUGH SECURABLE TO A GUIDE FOR THE MACHINE. A BRACKET IS ATTACHED TO THE MACHINE AND CARRIES A FEED ARM THROUGH WHICH THE SUPPLY LINE PASSES TO THE MACHINE, THE ARM EXTENDING INTO THE TROUGH TO FEED THE LINE THEREINTO. THE TROUGH IS PROVIDED WITH A NUMBER OF DISPLACEABLE RESILIENT MEMBERS, FOR EXAMPLE LOOPS OF RESILIENT FLEXIBLE MATERIAL, WHICH PROVIDE A GATE ACROSS THE TROUGH. UPON MOVEMENT OF THE MACHINE THE MEMBERS ARE DISPLACED BY THE ARM WHICH FEEDS THE LINE INTO THE TROUGH BELOW THE MEMBERS WHICH, AFTER THE MACHINE HAS PASSED, RETURN TO THEIR ENTRAPPING POSITION AND RETAIN THE LINE WITHIN THE TROUGH.

Water Distillation Apparatus, Method and System

A distillation device may comprise a source fluid input and an evaporator in fluid communication therewith. The device may further comprise a compressor having an impeller coupled to a motor, the compressor having a low pressure inlet for vapor from the evaporator and a high pressure outlet for compressed vapor. The device may further comprise at least one temperature sensor configured to monitor temperature of vapor in the inlet and a condenser in heat transfer relationship with exterior surfaces of the evaporator and in fluid communication with the compressor outlet. The device may further comprise a controller configured to govern rotation speed of the impeller with an impeller motor command based on a calibrated motor speed for the distillation device. The controller may be configured to determine an adjusted motor speed for a next use of the device and overwrite the calibrated motor speed with the adjusted motor speed.

substituted pyrazolinyl derivatives, processes for their preparation and their use as herbicides and / or plant growth regulators

derivados de pirazolinil substituídos, processos para sua preparação e seu uso como herbicidas e/ou reguladores de crescimento da planta. primeiramente, a presente invenção se refere a determinados pirazolinilpirrolonas e pirazolinil hidantoínas da fórmula (i) definidos abaixo ou seus sais e seu uso como herbicidas, em particular para controlar ervas daninhas de folhagem ampla e/ou gramas daninhas em plantações de plantas úteis e/ou como reguladores de crescimento da planta para influenciar o crescimento de plantações de plantas úteis. além disso, a presente invenção se refere a composições de herbicida e/ou de regulação do crescimento da planta que compreende um ou mais compostos da fórmula (i) e a processos de preparação dos compostos da fórmula (i). substituted pyrazolinyl derivatives, processes for their preparation and their use as herbicides and / or plant growth regulators. Firstly, the present invention relates to certain pyrazolinylpyrrolones and pyrazolinyl hydantoins of formula (I) defined below or their salts and their use as herbicides, in particular to control broadleaf weeds and / or weeds in useful plantations and / or as plant growth regulators to influence the growth of useful plantations. furthermore, the present invention relates to herbicide and / or plant growth regulating compositions comprising one or more compounds of formula (i) and processes for preparing the compounds of formula (i).

3-heteroaryl isoxazoline-5-carboxamides and 3-heteroaryl isoxazoline-5-thioamides with herbicidal and fungicidal activity

resumo patente de invenção: "3-heteroaril-isoxazolina-5-carboxamidas e 3-heteroaril-isoxazolina-5-tioamidas com atividade herbicida e fungicida". são descritas 3-heteroaril-isoxazolina-5-carboxamidas e 3-heteroaril-isoxazolina-5-tioamidas com atividade herbicida e fungicida da fórmula (i). nesta fórmula (i), r representa radicais tais como hidrogênio, halogênio e radicais orgânicos tais como alquila substituída. a é uma ligação ou uma unidade divalente. y é um calcogênio. patent abstract: "3-heteroaryl isoxazoline-5-carboxamides and 3-heteroaryl isoxazoline-5-thioamides with herbicidal and fungicidal activity". 3-heteroaryl-isoxazoline-5-carboxamides and 3-heteroaryl-isoxazoline-5-thioamides with herbicidal and fungicidal activity of formula (i). in this formula (i), r represents radicals such as hydrogen, halogen and organic radicals such as substituted alkyl. a is a bond or a divalent unit. y is a calcogen.

Media Fusion Remote Access System

The present invention is a system that receives data in different formats from different devices/applications in the format native to the devices/applications and fuses the data into a common shared audio/video collaborative environment including a composite display showing the data from the different sources in different areas of the display and composite audio. The common environment is presented to users who can be at remote locations. The users are allowed to supply a control input for the different device data sources and the control input is mapped back to the source, thereby controlling the source. The location of the control input on the remote display is mapped to the storage area for that portion of the display and the control data is transmitted to the corresponding device/application. The fusion system converts the data from the different sources/applications into a common format and stores the converted data from the different sources in a shared memory with each source allocated a different area in the memory. A combined window like composite representation of the data is produced and also stored in the memory. The combined representation is transmitted to and can be controlled by the users.

Close packed, end face, diode pumped, fibre laser bundle, phased-array laser oscillator

This invention relates to a scaleable, phase-locked, fiber laser array laser oscillator system consisting of a bundle of single mode optical fiber lasers, which can be combined into tapes (16), one end of said bundle being compacted into a solid face (3) which acts as the output aperture of the invention whilst the other ends (6) of the fiber lasers, forming said bundle, are loosely bound either individually or in groups and connected to semiconductor light sources (7), or optical excitation sources with equivalent output characteristics, for the end pumping of said fiber lasers in such a manner that all can be excited simultaneously or in a selected sequence.

Single cell analyses

This disclosure describes improvements to both hardware and enzymatic reactions used in single cell analyses such as but not limited to Seq-well that enable significant increases in the yield of transcripts per cell, improved portability and ease of use, increased scalability of the assay, and linkage of transcript information to other measurements made in the picowell arrays.

Refrigerant compositions of monochlorodifluoromethane, pentafluoroethane and 1,1,1,2-tetrafluoroethane

Compositions comprising from about 1 to about 90 weight percent monochlorodifluoromethane, from about 1 to about 90 weight percent pentafluoroethane and from about 1 to about 50 weight percent 1,1,1,2-tetrafluoroethane are useful refrigerants for heating and cooling.

Aiming system for weapon capable of superelevation

A grenade machine gun or other weapon which employs superelevation of the barrel comprises a barrel unit and an aiming system mounted upon a support. The aiming system is mounted to the weapon and the support by a coupling unit. The aiming system comprises an imaging and display unit for displaying an image of a scene including a target, angle encoders for providing a signal representing displacement of the imaging unit in elevation relative to the support, and a control unit, e.g. a computer, for selecting either of two states for the coupling unit. The first state entrains the imaging unit to move with the barrel. The second state secures the imaging unit to the support and allows the barrel to move relative to both, i.e. during superelevation of the barrel. The coupling unit may comprise a first part connected to the weapon for rotation in elevation with the barrel unit and a second part connected to the imaging unit. The control unit may comprise a computer for superimposing upon the image an aiming reticle and a rangefinder reticle, the former representing an aiming point of the imaging unit and the latter representing an aiming point of the rangefinder, and may adjust the position of the aiming reticle in dependence upon the elevation signal, and stores coordinates for selected positions. The control computer may offset the displacement signal to displace the aiming reticle relative to the field of view in a direction opposite to the required superelevation angle.

8 - iso - and d - homo - 8-iso - steroids

Tool

Disclosed is a tool ( 5 ) comprising a cam track (A) and cam follower means (B), wherein the cam track (A) comprises a first cam track wall means ( 15 ) and the cam follower (B) comprises a first cam follower wall means ( 15 ), and the first cam track wall means ( 10 ) and first cam follower wall means ( 15 ) face one another. The cam track (A) further comprises a second cam track wall means ( 30 ) and the cam follower (B) comprise a second cam follower wall means ( 35 ), and the second cam track wall means ( 30 ) and second cam follower wall means ( 35 ) face one another. The first and second cam track wall means ( 10, 30 ) are disposed so as to face one another. The first and second cam follower wall means are disposed so as to oppose one another, e.g. back to back. The first/second cam track wall means ( 10, 30 ) comprise a first/second cam track wave ( 20, 40 ). The second cam follower wall means ( 15, 35 ) comprise a first/second cam follower wave ( 25, 45 ).

Compositions containing difluoromethane, tetrafluoropropene, and carbon dioxide and uses thereof

In accordance with the present invention refrigerant compositions are disclosed. The compositions comprise a refrigerant mixture consisting essentially of HFC-32, HFO-1234yf, and CO 2 . The compositions are useful in processes to produce cooling and heating, in methods for replacing refrigerant R-32, and in refrigeration, air conditioning or heat pump systems. These inventive compositions are match cooling performance for R-32 with GWP less than 400 or less than 300.

Method of chromizing

Process for separating organomagnesium compounds from other compounds

Organotin compounds and compositions containing the same

Flame retardant clear coatings for building panels

Described herein is a barrier coating composition comprising an organic blend comprising a first component and a second component, the first component comprising latex polymer and the second component being selected from polyurethane emulsion, wax emulsion, and alkyd emulsion, wherein the first component and the second component are present in a weight ratio ranging from about 2:1 to about 20:1, and the latex polymer has a glass transition temperature of less than about 18 C.

Method for producing low-carbon ferrochromium

High-density optical data recording

A method to record data in a solid substrate comprises modulating a polarization angle of a coherent optical pulsetrain, and, while the polarization angle is being modulated, focusing the coherent optical pulsetrain on a locus moving through the solid substrate at a relative velocity. Here the relative velocity, a width of the locus in a direction of the relative velocity, and a rate of modulation of the polarization angle are such that the substrate receives within the width of the locus two or more pulses of the optical pulsetrain differing in polarization angle. In this manner, the two or more pulses record, in different portions of the substrate within the width of the locus, two or more different symbols.

high solids coating for building panels

É aqui descrita uma composição de revestimento adequada para aplicação a um painel de construção. A composição de revestimento compreende pigmento inorgânico, veículo líquido, e um umectante que compreende um primeiro composto que contém um éster. O veículo líquido pode estar presente numa quantidade que varia de cerca de 10% em peso a cerca de 30% em peso com base no peso total da composição de revestimento. aqui descrito também estão a construir painéis revestidos com a composição e métodos para a sua produção de revestimento. A coating composition suitable for application to a building panel is described herein. The coating composition comprises inorganic pigment, liquid carrier, and a humectant that comprises a first compound that contains an ester. The liquid carrier can be present in an amount ranging from about 10% by weight to about 30% by weight based on the total weight of the coating composition. described here are also building panels coated with the composition and methods for their coating production.

high solids edge coatings for construction panels

É aqui descrita uma composição de revestimento adequada para aplicação a um painel de construção. A composição de revestimento compreende pigmento inorgânico, veículo líquido, e um umectante que compreende um primeiro composto que contém um éster. O veículo líquido pode estar presente numa quantidade que varia de cerca de 10% em peso a cerca de 30% em peso com base no peso total da composição de revestimento. aqui descrito também estão a construir painéis revestidos com a composição e métodos para a sua produção de revestimento. A coating composition suitable for application to a building panel is described herein. The coating composition comprises inorganic pigment, liquid carrier, and a humectant that comprises a first compound that contains an ester. The liquid carrier can be present in an amount ranging from about 10% by weight to about 30% by weight based on the total weight of the coating composition. described here are also building panels coated with the composition and methods for their coating production.

Ultrasonic device