16-03-2017 дата публикации
Номер: US20170072116A1
Принадлежит:
According to the invention there is provided inter alia a medical device for delivering a paclitaxel to a tissue, the device the device having a coating layer applied to a surface of the device, the coating layer comprising components i), ii) and iii), wherein 1. A medical device for delivering a therapeutic agent to a tissue , the device having a coating layer applied to a surface of the device , the coating layer comprising components i) , ii) and iii) , whereincomponent i) is a therapeutic agent which is paclitaxel; andcomponent ii) is urea or a pharmaceutically acceptable salt thereof, or a urea derivative or a pharmaceutically acceptable salt thereof; andcomponent iii) is succinic acid, glutaric acid or caffeine, or a pharmaceutically acceptable salt of any one thereof.2. A medical device according to claim 1 , wherein the coating layer comprises a mixture of components i) claim 1 , ii) and iii).3. A medical device according to claim 1 , wherein component iii) is succinic acid.4. A medical device according to claim 1 , wherein component iii) is glutaric acid.5. A medical device according to claim 1 , wherein component iii) is caffeine.7. (canceled)8. (canceled)9. (canceled)10. A medical device according to claim 1 , wherein component ii) is methylurea claim 1 , ethylurea claim 1 , propylurea claim 1 , butylurea claim 1 , pentylurea claim 1 , or octylurea.11. (canceled)12. A medical device according to claim 1 , wherein the proportion of component i) in the coating layer is 10-95% by weight claim 1 , such as 40-90% claim 1 , 50-90% claim 1 , 60-90% claim 1 , 70-90% or 75-85% by weight claim 1 , the proportion of component ii) in the coating layer is 1-95% by weight claim 1 , such as 5-80% claim 1 , 5-50% claim 1 , 5-30% claim 1 , 5-20% or 5-15% by weight claim 1 , and the proportion of component iii) in the coating layer is 1-95% by weight claim 1 , such as 5-80% claim 1 , 5-50% claim 1 , 5-30% claim 1 , 5-20% or 5-15% by weight.13. (canceled)14. (canceled)15. A ...
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