System and Method for Joint Resurface Repair

A system for positioning an element relative to an articular surface. An embodiment of the system may include a first element having a positional reference relative to an articular surface. The system may further include a second element capable of indicating the positional reference of the first element relative to said articular surface. Of course, many alternatives, variations, and modifications are possible without departing from this embodiment. 1. An implant system , comprising:a post comprising a threaded portion configured to engage bone beneath a patient's articular surface, said post further comprising a first tapered portion;an implant comprising a load bearing surface, a bone facing surface, and a second tapered portion;wherein said first and said second tapered portions are configured to couple said post to said implant.2. The implant system according to claim 1 , wherein said first and said second tapered portions are further configured allow said implant to be aligned into a final alignment with respect to said articular surface and said post before said implant is secured to said post.3. The implant system according to claim 1 , wherein said first tapered portion comprises a male member and said second tapered portion comprises a female member.4. The implant system according to claim 3 , wherein said male member comprises a generally cylindrical extension having a taper.5. The implant system according to claim 4 , wherein said female member comprises a protrusion extending generally outwardly from a bone-facing distal surface claim 4 , said protrusion including a tapered recess.6. The implant system according to claim 1 , wherein said first tapered portion comprises a female member and said second tapered portion comprises a male member.7. The implant system according to claim 6 , wherein said female member comprises a tapered recess disposed proximate a proximal-most end of said post.8. The implant system according to claim 6 , wherein said male ...

System and Method for Joint Resurface Repair

An implant comprising a first, second, and third segment wherein the second and third segments partially overlap the first segment and define a load bearing surface comprising an anterior-posterior (AP) curvature including at least two tangential curves of the portion of the articular surface of the femoral condyle, the tangential curves having different radii of curvature. A drill guide comprises a body portion including a first, second and third bushing spaced along the body portion to establish a first, second and third axes, respectively. Each axis may be substantially normal to the articular surface at three different points along a curvature of the articular surface comprising the two tangential curves. A measuring device comprises a housing defining a longitudinally passageway and an outrigger. A guide pin may be received in the longitudinal passageway and a measuring device determines how far the guide pin is in the passageway. 1. An implant for replacing a portion of an articular surface of a bone comprising:at least a first and a second segments each comprising a truncated, generally arcuate perimeter corresponding to a first, and a second overlapping generally circular excision site formed in said articular surface, respectively, wherein said second segments partially overlap said first segment on a first end of said first segment, said first and said second segments comprise a bone contacting surface and a load bearing surface, said load bearing surface comprising curvature corresponding to a curvature of said replaced portion of said articular surface of said bone.2. The implant of claim 1 , wherein said bone contacting surface comprises a first mounting feature configured to secure said implant to said bone.3. The implant of claim 2 , wherein said bone facing surface of said first segment includes said first mounting feature.4. The implant of claim 2 , wherein said first mounting feature is configured to securely engage with a fastening element claim 2 ...

Process for the extraction of high molecular weight naphthenic acids from calcium naphthenate salts

A method for recovering high molecular weight naphthenic tetra-acids, particularly ARN acids from a calcium naphthenate deposit. Calcium naphthenate deposits contain large amounts of calcium naphthenate salts of ARN acids. The method dual solvent extraction process in which the naphthenic tetra-acids chemically bound as calcium naphthenate salts are converted into free acid monomers by an aqueous acid. The resulting free acid monomers are then dissolved into an organic solvent phase and the counterions dissolve in the aqueous acid phase. The naphthenic tetra-acids are then recovered from the organic solvent phase.

APPARATUS FOR TISSUE REPAIR

An apparatus for tissue repair, comprising first and second fixation members, a flexible coupling member coupling the first and second fixation members, the flexible coupling member having two terminal ends, one of the two terminal ends terminating adjacent one of the first and second fixation members, the flexible coupling member slidably coupled to at least one of the first and second fixation members such that when the other of the two terminal ends of the flexible coupling member is pulled, a length of the flexible coupling member between the first and second fixation members is shortened, and a Chinese trap formed in the flexible coupling member through which a portion of the flexible coupling member slides when the flexible coupling member is pulled. 1. An apparatus for tissue repair , comprising:first and second fixation members;a flexible coupling member coupling the first and second fixation members, the flexible coupling member having two terminal ends, one of the two terminal ends terminating adjacent one of the first and second fixation members, the flexible coupling member slidably coupled to at least one of the first and second fixation members such that when the other of the two terminal ends of the flexible coupling member is pulled, a length of the flexible coupling member between the first and second fixation members is shortened; anda Chinese trap formed in the flexible coupling member through which a portion of the flexible coupling member slides when the flexible coupling member is pulled.2. The apparatus of comprising a closed loop of flexible material coupling one of the first and second fixation members to the flexible coupling member claim 1 , the flexible coupling member being slidably received through the closed loop of flexible material.3. The apparatus of being preassembled for use in a surgical procedure.4. The apparatus of wherein the other of the two terminal ends of the flexible coupling member is slidably received within the Chinese ...

System and Method for Bone Fixation

A fixation system for coupling a first and a second portion of bone together. The fixation system includes a first fixation element, a second fixation element, and an interconnect. The first fixation element includes an external surface configured to engage the first portion of bone and a first tapered mating surface. The second fixation element includes an external surface configured to engage the second portion of bone and a second tapered mating surface. The interconnect includes a first and a second tapered surface disposed at generally opposite ends. The first and the second tapered surfaces are configured to frictionally engage the first and the second tapered mating surfaces of the first and the second element, respectively, to form frictional interference connections therebetween. 1. A fixation system for coupling a first and a second portion of bone together , said fixation system comprising:a first fixation element having an external surface configured to engage said first portion of bone, said first fixation element including a first tapered mating surface;a second fixation element having an external surface configured to engage said second portion of bone, said second fixation element including a second tapered mating surface; andan interconnect comprising a first and a second tapered surface disposed at generally opposite ends, said first and said second tapered surfaces configured to frictionally engage said first and said second tapered mating surfaces of said first and said second element, respectively, to form frictional interference connections therebetween.2. The fixation system of claim 1 , wherein said first fixation element defines a first generally cylindrical element having said first tapered mating surface; andwherein said interconnect includes a first tapered generally cylindrical portion having said first tapered surface configured to frictionally engage said first tapered mating surfaces of said first fixation element.3. The fixation ...

System and Method for Bone Fixation

A fixation system for coupling a first and a second portion of bone together. The fixation system includes a first fixation element, a second fixation element, and an interconnect. The first and second fixation elements include external surfaces configured to engage the first and second portions of bone, respectively, and a first and second mating surface, respectively. The interconnect includes a first and a second surface disposed at generally opposite ends, which are configured to engage the first and the second mating surfaces of the first and the second element, respectively, to form connections therebetween. At least one of the first mating surface, the second mating surface, the first surface, or the second surface is configured to deform when coupling the first fixation element, the second fixation element, or the interconnect. 1. A fixation system for coupling a first and a second portion of bone together , said fixation system comprising:a first fixation element having an external surface configured to engage said first portion of bone, said first fixation element including a first mating surface;a second fixation element having an external surface configured to engage said second portion of bone, said second fixation element including a second mating surface; andan interconnect comprising a first and a second mating portion disposed at generally opposite ends, said first and said second mating portions configured to engage said first and said second mating surfaces of said first and said second element, respectively, to form connections therebetween;wherein at least one of said first mating surface, said second mating surface, said first mating portion, or said second mating portion is configured to deform when coupling said first fixation element, said second fixation element, or said interconnect.2. The fixation system of claim 1 , wherein at least one of said first mating surface claim 1 , said second mating surface claim 1 , said first mating portion ...

CLOSURE DEVICE AND METHOD FOR TISSUE REPAIR

A method of closing a tissue wound includes providing a wound closure device having a first anchor, a second anchor, and a flexible member movably attached to the second anchor, positioning the first anchor against tissue, passing the flexible member across the wound, positioning the second anchor against tissue, and pulling on a free end of the flexible member to shorten a length of the flexible member between the first and second anchors, thereby closing the wound. A wound closure device includes a first anchor, a second anchor; and a flexible member connecting the first anchor to the second anchor, the flexible member being movably attached to the second anchor, such that pulling on a free end of the flexible member shortens a length of the flexible member between the first and second anchors. 1. A wound closure device comprising:a first anchor;a second anchor; anda flexible member connecting the first anchor to the second anchor, the flexible member being movably attached to the second anchor, such that pulling on a free end of the flexible member shortens a length of the flexible member between the first and second anchors.2. The device of claim 1 , wherein the movable attachment of the flexible member to the second anchor enables the length of the flexible member between the first and second anchors to be shortened claim 1 , but not lengthened.3. The device of claim 2 , wherein the movable attachment includes a knot formed in the flexible member at the second anchor.4. The device of claim 3 , wherein the knot includes a first portion of the flexible member that forms a loop claim 3 , and a second portion that passes over a surface of the second anchor and through the loop.5. The device of claim 4 , wherein the surface comprises an exterior surface of the second anchor.6. The device of claim 4 , wherein the knot is configured such that pulling on the free end causes the flexible member to slide through the loop to shorten the length of the flexible member ...

SYSTEM AND METHOD FOR JOINT RESURFACING AND REPAIR

An implant resection system for preparing an implant site to replace a defect in an articular surface of a first bone includes a first guide configured to be coupled generally to the first bone. The first guide includes a body portion defining a channel configured to receive a pin, wherein the pin is configured to penetrate and form a longitudinally disposed bore within the first bone. The implant resection system further includes a second guide configured to be coupled generally perpendicular to the first bone proximate to the defect by way of the bore. The second guide includes a drill bit configured to form an excision site through a portion of the articular surface in preparation of receipt of an implant. 1. An implant resection system for preparing an implant site to replace a defect in an articular surface of a first bone , said implant resection system comprising:a first guide configured to be coupled to a first bone, said first guide comprising a body portion having at least one channel defined on a portion thereof, said channel configured to extend generally perpendicular to a portion of said first bone proximate to said defect; andat least one pin configured to be received and retained within said channel, said pin having a distal end configured to pierce said first bone and to extend and form a longitudinally disposed bore within said first bone.2. The implant resection system of claim 1 , further comprising:an arm extending outwardly from a distal face of said body portion of said first guide; anda spoon disposed about a distal end of said arm, said spoon configured to be disposed between said articular surface of said first bone and an articular surface of a second cooperating bone.3. The implant resection system of claim 2 , wherein said spoon further comprises a generally convex base portion configured to abut against said articular surface of said cooperating bone and a generally concave upper portion configured to abut against said articular surface ...

System for Articular Surface Replacement

A system for replacing a portion of an articular surface including providing an implant site and installing an implant into the implant site. The implant site includes a first and a second excision site which at least partially intersect with one another. Each of the first and second excision sites are formed by providing a respective axis and excising a portion of the articular surface relative to the respective axes. 120-. (canceled)21. A system comprising:a guide comprising a body portion including:a first opening extending through said body portion, said first opening aligned along a reference axis extending outward from said articular surface; anda second opening extending through said body portion, said second opening aligned along a working axis extending outward from said articular surface at a predetermined relationship with respect to said reference axis.22. The system of claim 21 , further comprising:a location element configured within said bone along said reference axis.23. The system of claim 22 , further comprising a guide rod configured to extend from said location element.24. The system of claim 23 , wherein said guide rod is configured to be coupled to said guide.25. The system of claim 24 , wherein said guide rod is configured to be coupled to said guide to align said working axis with respect to said reference axis.26. The system of claim 24 , wherein said guide rod and said location element include mating features.27. The system of claim 26 , wherein said mating features include mating tapers.28. The system of claim 22 , wherein said location element includes a screw.29. The system of claim 22 , wherein said location element is configured to be secured in said bone at a predetermined height relative to said articular surface.30. The system of claim 29 , wherein said predetermined height is selected such that a portion of said location element is tangential with an arc defined by said articular surface.31. The system of claim 22 , further ...

Trochlear Resurfacing System and Method

A system for repairing a defect on an articular surface of a patient's trochlear region, the system comprising a guide block comprising a body having an exterior surface configured to engage with the saddle portion and ridge portions of the patient's trochlear region, a protrusion extending generally from the body and configured to be received in a first bore formed in the articular surface along a reference axis, and a first cavity extending through the body configured to establish a first working axis displaced from the reference axis, wherein the exterior surface of the body and the protrusion are configured to secure the location of the guide block about the patient's trochlear region. A method for preparing an implant site in bone, comprising: establishing a reference axis extending from the bone; creating a bore in the bone by reaming about the reference axis; securing a guide block about the articular surface; establishing a first working axis extending from the bone using the guide block, the first working axis is displaced from the reference axis; and creating a first socket in the bone by reaming about the first working axis, wherein the first socket partially overlaps with the bore.

Anchor for an Implant Assembly

A medical device includes an implant anchor comprising first and second opposing end portions. The implant anchor may also include a fixation element to configured to couple the implant anchor to an implant, and an anchor element configured to couple the implant anchor to bone. At least a portion of the implant anchor has a porous structure. 1. A medical device , comprising:an implant anchor comprising first and second opposing end portions, said implant anchor further comprising:a fixation element to configured to couple said implant anchor to an implant; and an anchor element configured to couple said implant anchor to bone, said anchor element of said implant anchor comprises a threaded portion, at least a portion of said threaded portion is formed by said porous structure.2. The medical device of claim 1 , wherein:said fixation element has a non-porous-structure.3. The medical device of claim 1 , wherein:said second end portion of said implant anchor comprises said anchor element; andat least a portion of said anchor element is formed by said porous structure.4. (canceled)5. The medical device of claim 1 , wherein:said threaded portion of said implant anchor comprises a threaded shank; andat least a portion of said threaded shank is formed by said porous structure.6. The medical device of claim 5 , wherein:said threaded shank of said implant anchor comprises a screw thread;at least a portion of said screw thread is formed by said porous structure.7. The medical device of claim 5 , wherein:said threaded shank of said implant anchor comprises a screw thread;at least a portion of said screw thread is formed by a non-porous structure.8. The medical device of claim 5 , wherein:said threaded shank of said implant anchor comprises a shank root; andat least a portion of said shank root is formed by said porous structure.9. The medical device of claim 1 , wherein:said porous structure is formed by metal particles.10. The medical device of claim 1 , wherein:said porous ...

Retrograde Resection Apparatus and Method

A retrograde resection apparatus may include a cutting blade including a slot defined in the cutting blade, a recess defined in at least a portion of the slot, a screw, including a proximal end and a distal end defining a bore therethrough, a shaft having a distal end and a proximal end, wherein the shaft passes through the bore and the distal end is configured to be received in the recess, and a biasing device configured to bias the shaft against the cutting blade. In addition, the apparatus may include a tether, a first portion of which is affixed to the cutting blade and a second portion of which passes through the bore. 1. A retrograde resection apparatus , comprising:a cutting blade having a body defining a first surface and a second surface, including at least one cutting feature provided on said second surface;a slot defined through at least a portion of said body;a recess defined in at least a portion of said slot;a shaft having a distal end and a proximal end, wherein a portion of said distal end is received in said recess; anda biasing device configured to bias said shaft against said cutting blade.2. The apparatus of claim 1 , further comprising:a hemispherical protrusion extending from said distal end of said shaft, wherein said protrusion is configured to be at least partially received in said recess.3. The apparatus of claim 1 , wherein at least a portion of said distal end of said shaft is configured to be received in said slot.4. The apparatus of claim 1 , further comprising a screw claim 1 , including a proximal end and a distal end defining a bore therethrough claim 1 , received on said shaft.5. The apparatus of claim 4 , wherein said shaft is rotatable in said bore.64. The apparatus of claim 4 , wherein said screw includes a nut on said proximal end7. The apparatus of claim 4 , wherein said screw includes a plurality of continuous threads in a central portion and a tap proximate said distal end.8. The apparatus of claim 1 , further comprising:a ...

Anchor for an Implant Assembly

A medical device includes an implant anchor comprising first and second opposing end portions. The implant anchor may also include a fixation element to configured to couple the implant anchor to an implant, and an anchor element configured to couple the implant anchor to bone. At least a portion of the implant anchor has a porous structure. 1. A medical device , comprising: a fixation element to configured to couple said implant anchor to an implant; and', 'an anchor element configured to couple said implant anchor to bone;, 'an implant anchor comprising first and second opposing end portions, said implant anchor further comprisingwherein at least a portion of said implant anchor has a porous structure.2. The medical device of claim 1 , wherein:said fixation element has a non-porous-structure.3. The medical device of claim 1 , wherein:said second end portion of said implant anchor comprises said anchor element; andat least a portion of said anchor element is formed by said porous structure.4. The medical device of claim 3 , wherein:said anchor element of said implant anchor comprises a threaded portion; andat least a portion of said threaded portion is formed by said porous structure.5. The medical device of claim 4 , wherein:said threaded portion of said implant anchor comprises a threaded shank; andat least a portion of said threaded shank is formed by said porous structure.6. The medical device of claim 5 , wherein:said threaded shank of said implant anchor comprises a screw thread;at least a portion of said screw thread is formed by said porous structure.7. The medical device of claim 5 , wherein:said threaded shank of said implant anchor comprises a screw thread;at least a portion of said screw thread is formed by a non-porous structure.8. The medical device of claim 5 , wherein:said threaded shank of said implant anchor comprises a shank root; andat least a portion of said shank root is formed by said porous structure.9. The medical device of claim 1 , ...

SYSTEM AND METHOD FOR REPAIRING ARTICULAR SURFACES

A total joint replacement system comprising a first and a second implant system. The first implant system includes a first implant having a first load bearing surface based on a first removed portion of an articular surface of a patient's first bone, and a first anchor having a first threaded region configured to be secured into the first bone, wherein the first anchor is configured to be secured to the first implant. The second implant system includes a second implant having a second load bearing surface based on a second removed portion of an articular surface of a patient's second bone, and a second anchor having a second threaded region configured to be secured into the second bone, wherein the second anchor is configured to be secured to the second implant. 149-. (canceled)50. A joint replacement system for repairing a first articular surface and a second articular surface corresponding to a humerus and a oppositely arranged glenoid cavity , respectively , said system comprising: a first implant having a first load bearing surface; and', 'a first anchor having a first threaded region configured to be secured into said humerus, wherein said first anchor is configured to be secured to said first implant; and, 'a humerus implant system comprising a second implant having a hemispherical load bearing surface configured to articulate against said first load bearing surface; and', 'a second anchor having a second threaded region configured to be secured into said glenoid cavity, wherein said second anchor is configured to be secured to said second implant., 'a glenoid cavity implant system comprising51. The joint replacement system of claim 50 , wherein said second implant and said second anchor include a first and a second fixation element claim 50 , respectively.52. The joint replacement system of claim 51 , wherein said first and said second fixation elements are configured to form tapered connection therebetween.53. The joint replacement system of claim 52 , ...

System and method for repairing articular surfaces

A joint replacement system for repairing an articular surface of a first bone of a joint includes an anchor portion and an implant portion. The anchor portion includes an anchor to be secured to the bone, and an anchor fixation head including a bone-facing surface (BFS) extending radially outward from the anchor and an implant facing surface (IFS) extending from a periphery of the BFS. The implant portion is formed from a material (e.g., CoCr) more dense than the material of the anchor portion (e.g., Ti) and includes a fixation cavity to receive at least a portion of the anchor fixation head (AFH), the fixation cavity includes an anchor facing surface (AFS) configured to form a frictional connection with the IFS, and a load bearing surface having a contour for articulating against a cooperating articulating surface of a second bone of the joint.

Delivery System for Articular Surface Implant

A implant delivery system for securing an implant to an anchor. The implant delivery system includes a driver including a shaft, a biasing body having a first end region configured to engage said driver and a second end region configured to engage a portion of an implant, and a suture extending between the anchor and the shaft of the driver. The driver may be rotated to reduce the length of the suture between the driver and the anchor and generate a biasing force urging the implant into engagement with the anchor. The biasing force is substantially not transmitted to the bone. 1. A delivery system for securing an implant with an anchor , the delivery system comprising:a driver including a shaft, said driver configured to wind a portion of a suture, said suture configured to extend around a contact portion of said anchor disposed within a bone; anda biasing body having a first end region including a driver cradle configured to generally retain a portion of said shaft as said driver is rotated relative to said biasing body, and a second end region configured to engage a portion of said implant;wherein rotation of said driver applies a biasing force against said implant and said anchor to secure said implant with said anchor, and wherein said biasing force is substantially not transmitted to said bone.2. The delivery system of claim 1 , further comprising said suture claim 1 , wherein said suture includes a first region configured to be generally secured to said shaft and a second region configured to be disposed about said contact portion of said anchor.3. The delivery system of claim 2 , wherein said second region of said suture includes a first and a second portion defining a cradle configured to engage said contact portion of said anchor.4. The delivery system of claim 3 , wherein said biasing body is configured to maintain a separation angle of said first and second portions of said cradle.5. The delivery system of claim 1 , wherein said driver cradle includes an ...

MULTICOMPONENT ARTICULAR SURFACE IMPLANT

A multicomponent implant system includes a multicomponent implant comprising a base plate and a load plate. The base plate includes a bone facing surface and a base plate interface surface. The load plate includes a load plate interface surface and a load bearing surface, the load bearing surface being substantially parallel to the load plate interface surface and having a contour substantially corresponding to a contour of a removed portion of the articular surface. Both the load plate interface surface and base plate interface surface have a contour substantially corresponding to the contour of the load bearing surface. The load plate is configured to be advanced in an arcuate direction to slidably couple the load plate to the base plate after the base plate has been secured within the first excision site by an anchor. 1. An implant system comprising: [ ["a load plate comprising a load bearing surface and a load plate interface surface, wherein said load bearing surface has a contour substantially corresponding to a contour of a removed portion of a patient's articular surface of a first bone, and wherein said load plate interface surface has a contour along said first axis that substantially corresponds to the contour of the load bearing surface along said first axis; and", "a base plate comprising a bone facing surface and a base plate interface surface, said bone facing surface configured to engage said first bone within a first excision site beneath said removed portion of said patient's articular surface, and said base plate interface surface having a contour along said first axis that substantially corresponds to the contour of the load plate interface surface along said first axis; and"], 'a multicomponent implant having a proximal end and a distal end and a first axis extending therebetween when assembled, said multicomponent implant comprising, 'a multicomponent implant anchor configured to be secured to said first bone and to secure said base plate ...

IMPLANT AND ANCHOR ASSEMBLY

An implant assembly comprising an implant having a load bearing surface with a contour corresponding to a patient's articular surface, and a bone facing surface including a fixation element, an anchor configured to be secured to bone beneath said patient's articular surface, said anchor including a second fixation element, and wherein said first fixation element is configured to be secured to said second fixation element. 1. An implant assembly comprising:an implant having a load bearing surface with a contour corresponding to a patient's articular surface, and a bone facing surface including a first fixation element;an anchor configured to be secured to bone beneath said patient's articular surface, said anchor including a second fixation element; andwherein said first fixation element is configured to be secured to said second fixation element;wherein said first fixation element and said second fixation element are configured to mechanically connect with each other to form a mechanical connection therebetween, said first fixation element and said second fixation element are further configured to frictionally engage with each other to form a frictional connection therebetween;one of said first fixation element or said second fixation element comprises a protrusion having a protrusion sidewall;said protrusion sidewall includes at least one protrusion sidewall fixation feature, said at least one protrusion sidewall fixation feature comprises a plurality of ribs and a least one plurality of relief recesses, and the plurality of ribs are separated by the plurality of relief recesses.2. The implant assembly of claim 1 , wherein:said at least one relief recesses extends longitudinally along a longitudinal length of said protrusion.3. The implant assembly of claim 1 , wherein:said plurality of ribs are substantially equally spaced around a circumference of said protrusion.4. The implant assembly of claim 1 , wherein:said plurality of ribs are substantially parallel to ...

System for Articular Surface Replacement

A system for replacing a portion of an articular surface including providing an implant site and installing an implant into the implant site. The implant site includes a first and a second excision site which at least partially intersect with one another. Each of the first and second excision sites are formed by providing a respective axis and excising a portion of the articular surface relative to the respective axes. 1. A method of replacing a portion of an articular surface comprising:forming a first excision site relative to a first axis relative to said articular surface;forming a second excision site relative to a second axis relative to said articular surface, at least a portion of said second excision site intersecting at least a portion of said first excision site; andinstalling an implant at least partially in said first and second excision sites, said implant having a load bearing surface comprising a contour based on an original contour of said articular surface.2. A method according to claim 1 , wherein said implant site is formed in a femoral articular surface.3. A method according to claim 1 , wherein said first axis is defined by providing a guide pin extending from said articular surface.4. A method according to claim 3 , wherein providing said guide pin extending from said articular surface comprises providing a hole extending into said articular surface and disposing said guide pin at least partially in said hole and extending from said articular surface.5. A method according to claim 1 , wherein forming said first excision site comprises excising said articular surface along a circular excision path around said first axis.6. A method according to claim 5 , wherein at least a portion of said circular excision path extends radially from said first axis beyond said articular surface.7. A method according to claim 1 , wherein said first axis is oriented normal to said articular surface at a point of intersection with said articular surface.8. A ...

Methods for Tissue Repair

A method of closing a tissue wound includes providing a wound closure device having a first fastener, a second fastener, and a flexible member extending between the first and second fasteners and movably attached to the second fastener by a one-way knot formed in the flexible member between the first and second fastener, positioning the first fastener against tissue, passing the flexible member across the wound, positioning the second fastener against tissue, and pulling on a free end of the flexible member to shorten a length of the flexible member between the first and second fasteners, thereby closing the wound. 1. A method of closing a tissue wound comprising:providing a wound closure device having a first fastener, a second fastener, and a flexible member extending between the first and second fasteners and movably attached to the second fastener by a one-way knot formed in the flexible member between the first and second fastener;positioning the first fastener against tissue;passing the flexible member across the wound;positioning the second fastener against tissue; andpulling on a free end of the flexible member to shorten a length of the flexible member between the first and second fasteners, thereby closing the wound.2. The method of claim 1 , wherein the flexible member is slidably attached to the second fastener by the one-way knot claim 1 , such that after completion of the pulling step claim 1 , the length of the flexible member between the first and second fasteners remains shortened.3. The method of claim 1 , wherein the first positioning step includes positioning the first fastener on a first side of the wound claim 1 , the passing step includes passing the flexible member from the first side to a second side of the wound claim 1 , engaging tissue on the second side claim 1 , and returning the flexible member to the first side claim 1 , and the second positioning step includes positioning the second fastener on the first side of the wound.4. The ...

Tibial Resurfacing System and Method

An implant resection system for preparing an implant site to replace a defect in an articular surface of a first bone includes a guide configured to be coupled generally perpendicular to the first bone proximate to the defect. The guide includes a body portion defining a plurality of excision passageways. The excision passageways each define a generally cylindrical core pathway configured to extend generally perpendicular to the first bone which partially overlaps with an adjacent generally cylindrical core pathway. A projection associated with each of the plurality of the generally cylindrical core pathways defines a truncated cylindrical excision site extending through a portion of the articular surface. Each truncated cylindrical excision site partially overlaps with at least one adjacent truncated cylindrical excision site. 1. An implant system comprising an implant for replacing a defect in an articular surface of a bone , said implant including:a load bearing surface having a contour substantially corresponding to a contour of the articular surface corresponding to an implant site in the bone; anda bone facing surface including a first and a second truncated cylindrical protrusion extending along a length of said bone facing surface, wherein said first and said second truncated cylindrical protrusion are defined by a first and a second different truncated cylindrical projection.2. The implant system of claim 1 , wherein said first and said second truncated cylindrical protrusion define a first and a second generally opposite side of said bone facing surface claim 1 , respectively.3. The implant system of claim 1 , wherein said first and said second truncated cylindrical protrusion have the same diameter.4. The implant system of claim 1 , wherein said first and said second truncated cylindrical protrusion have the different diameters.5. The implant system of claim 1 , wherein said first and said second truncated cylindrical protrusion are spaced apart such that ...

HYBRID INLAY/ONLAY ARTICULAR SURFACE IMPLANTS AND METHODS

A hybrid inlay/onlay (HIO) implant system includes an implant and an anchor. The implant comprises an inlay component and an onlay component. The inlay component is configured to be at least partially received in an excision site and includes a bone facing surface configured to abut against the bone within the excision site. The onlay component comprises an uppermost surface and a stepped surface. The uppermost surface includes an articulating surface configured to articulate against an articulating surface associated with a second bone of the joint. The stepped surface is configured to abut against at least some of a remaining portion of the patient's native articular surface proximate the excision site and/or a peripheral step excision site formed proximate the excision site. The anchor is configured to extend away from the bone facing surface of the inlay segment and to secure the HIO implant system to the first bone. 1. A hybrid inlay/onlay (HIO) implant system for replacing at least a portion of a patient's native articular surface on a first bone in a joint , said HIO implant system comprising:{'claim-text': ["an inlay component configured to be at least partially received in an excision site formed in said first bone beneath a removed portion of a patient's native articular surface, said inlay component comprising a bone facing surface configured to abut against said bone within said excision site; and", "an onlay component comprising an uppermost surface and a stepped surface, said uppermost surface including an articulating surface configured to articulate against an articulating surface associated with a second bone of said joint and said stepped surface configured to abut against at least some of a remaining portion of said patient's native articular surface proximate to said excision site or a peripheral step excision site formed proximate to said excision site; and"], '#text': 'an implant comprising:'}an anchor configured to extend away from said bone ...

Optimized cancer stem cell vaccines

The present invention provides cancer stem cell vaccines useful for treating or preventing a variety of tumors, as well as related methods of producing cancer stem cells and antigens thereof and producing vaccine adjuvants with enhanced activity for use with the stem cell vaccines.

SYSTEM AND METHOD FOR REPAIRING ARTICULAR SURFACES

A joint replacement system for repairing an articular surface of a first bone of a joint includes an anchor portion and an implant portion. The anchor portion includes an anchor to be secured to the bone, and an anchor fixation head including a bone-facing surface (BFS) extending radially outward from the anchor and an implant facing surface (IFS) extending from a periphery of the BFS. The implant portion is formed from a material (e.g., CoCr) more dense than the material of the anchor portion (e.g., Ti) and includes a fixation cavity to receive at least a portion of the anchor fixation head (AFH), the fixation cavity includes an anchor facing surface (AFS) configured to form a frictional connection with the IFS, and a load bearing surface having a contour for articulating against a cooperating articulating surface of a second bone of the joint. 1. A joint replacement system for repairing at least a first articular surface of a first bone of a joint , said system comprising: [ a first anchor configured to be secured to said bone; and', 'an anchor fixation head including a bone-facing surface and an implant facing surface, wherein said bone-facing surface extends radially outward from said anchor, and wherein said implant facing surface extends from a periphery of said bone facing surface and includes a first mating surface; and, 'an anchor portion formed from at least a first material, said anchor portion comprising, a fixation cavity configured to receive at least a portion of said anchor fixation head, said fixation cavity including an anchor facing surface extending from an opening thereof, said anchor facing surface including a second mating surface configured to form a frictional connection with said first mating surface; and', 'a first load bearing surface having a contour for articulating against a cooperating, second articulating surface associated with a second bone of said joint., 'an implant portion formed from at least a second material more dense than ...

BIOABSORBABLE TEXTILES AND METHODS FOR JOINT FUNCTION RESTORATION

A bioabsorbable textile for the restoration of the joint function whereas the joint is affected by partial thickness tears, small to medium full-thickness tears, large to massive full-thickness tears, acute and chronic/degenerative tears. The bioabsorbable textile may comprise polymeric yarns interconnected to form a weave or knitted configuration, wherein said bioabsorbable textile provides a combined mechanical and biological augmentation in the target joint tissue. The bioabsorbable textile may be implanted in combination with fixation tools during open, mini-open or arthroscopic repair/augmentation procedures of joint tissue tears. 1. A bioabsorbable textile for joint function restoration comprising polymeric yarns ,wherein at least one of said polymeric yarns comprises a hyaluronic acid derivative.2. The bioabsorbable textile according to claim 1 , wherein said hyaluronic acid derivative is an ester.3. The bioabsorbable textile according to claim 2 , wherein said hyaluronic acid derivative is a benzyl ester.4. The bioabsorbable textile according to claim 3 , wherein the esterification degree of said hyaluronic acid derivative ranges between 80% to 100%.5. The bioabsorbable textile according to claim 1 , wherein the bioabsorbable textile is a knitted structure.6. The bioabsorbable textile according to claim 1 , wherein the bioabsorbable textile is a leno-weave structure.7. The bioabsorbable textile according to claim 1 , wherein said bioabsorbable textile is coated with an osteo-inductive and/or osteo-conductive material selected from the group consisting of hydroxyapatite claim 1 , calcium phosphates claim 1 , bone cements claim 1 , demineralized bone matrix claim 1 , titanium claim 1 , magnesium claim 1 , strontium claim 1 , bioglasses claim 1 , other resorbable glasses claim 1 , and a combination thereof.8. The bioabsorbable textile according to claim 1 , wherein the bioabsorbable textile is added to a biological component selected from the group consisting ...

System for Articular Surface Replacement

A system for replacing a portion of an articular surface including providing an implant site and installing an implant into the implant site. The implant site includes a first and a second excision site which at least partially intersect with one another. Each of the first and second excision sites are formed by providing a respective axis and excising a portion of the articular surface relative to the respective axes. 120-. (canceled)21. A system comprising: a first opening extending through said body portion, said first opening aligned along a reference axis extending outward from said articular surface; and', 'a second opening extending through said body portion, said second opening aligned along a working axis extending outward from said articular surface at a predetermined relationship with respect to said reference axis., 'a guide comprising a body portion including22. The system of claim 21 , further comprising:a location element configured within said bone along said reference axis.23. The system of claim 22 , further comprising a guide rod configured to extend from said location element.24. The system of claim 23 , wherein said guide rod is configured to be coupled to said guide.25. The system of claim 24 , wherein said guide rod is configured to be coupled to said guide to align said working axis with respect to said reference axis.26. The system of claim 24 , wherein said guide rod and said location element include mating features.27. The system of claim 26 , wherein said mating features include mating tapers.28. The system of claim 22 , wherein said location element includes a screw.29. The system of claim 22 , wherein said location element is configured to be secured in said bone at a predetermined height relative to said articular surface.30. The system of claim 29 , wherein said predetermined height is selected such that a portion of said location element is tangential with an arc defined by said articular surface.31. The system of claim 22 , further ...

Trochlear Resurfacing System and Method

A system for repairing a defect on an articular surface of a patient's trochlear region, the system comprising a guide block comprising a body having an exterior surface configured to engage with the saddle portion and ridge portions of the patient's trochlear region, a protrusion extending generally from the body and configured to be received in a first bore formed in the articular surface along a reference axis, and a first cavity extending through the body configured to establish a first working axis displaced from the reference axis, wherein the exterior surface of the body and the protrusion are configured to secure the location of the guide block about the patient's trochlear region. A method for preparing an implant site in bone, comprising: establishing a reference axis extending from the bone; creating a bore in the bone by reaming about the reference axis; securing a guide block about the articular surface; establishing a first working axis extending from the bone using the guide block, the first working axis is displaced from the reference axis; and creating a first socket in the bone by reaming about the first working axis, wherein the first socket partially overlaps with the bore. 1. A method for preparing an implant site in bone , comprising:establishing a reference axis extending from said bone;creating a bore in said bone by reaming about said reference axis;securing a guide block about said articular surface;establishing a first working axis extending from said bone using said guide block, said first working axis is displaced from said reference axis; andcreating a first socket in said bone by reaming about said first working axis, wherein said first socket partially overlaps with said bore.2. The method of claim 1 , wherein said guide block comprises a body including a base portion and sidewall portions having a generally arcuate shaped exterior surface generally configured to engage with the saddle portion and ridge portions of a patient's ...

IMPLANT AND ANCHOR ASSEMBLY

An implant assembly comprising an implant having a load bearing surface with a contour corresponding to a patient's articular surface, and a bone facing surface including a fixation element, an anchor configured to be secured to bone beneath said patient's articular surface, said anchor including a second fixation element, and wherein said first fixation element is configured to be secured to said second fixation element. 1. An implant assembly comprising:an implant having a load bearing surface with a contour corresponding to a patient's articular surface, and a bone facing surface including a first fixation element;an anchor configured to be secured to bone beneath said patient's articular surface, said anchor including a second fixation element; andwherein said first fixation element is configured to be secured to said second fixation element.2. The implant assembly of claim 1 , wherein:said implant comprises plastic; andsaid first fixation element and said second fixation element each comprise metal.3. The implant assembly of claim 1 , wherein:said implant comprises metal; andsaid first fixation element and said second fixation element each comprise plastic.4. The implant assembly of claim 1 , wherein:said first fixation element and said second fixation element are configured to mechanically connect with each other to form a mechanical connection therebetween.5. The implant assembly of claim 4 , wherein:said first fixation element and said second fixation element are further configured to frictionally engage with each other to form a frictional connection therebetween.6. The implant assembly of claim 5 , wherein:said first fixation element includes a tapered portion and said second fixation element includes a tapered portion; andsaid tapered portions are configured to frictionally engage with each other to form said friction connection therebetween.7. The implant assembly of claim 5 , wherein:said first fixation element comprises a tapered recess; andsaid second ...

SYSTEM AND METHOD FOR REPAIRING ARTICULAR SURFACES

A total joint replacement system comprising a first and a second implant system. The first implant system includes a first implant having a first load bearing surface based on a first removed portion of an articular surface of a patient's first bone, and a first anchor having a first threaded region configured to be secured into the first bone, wherein the first anchor is configured to be secured to the first implant. The second implant system includes a second implant having a second load bearing surface based on a second removed portion of an articular surface of a patient's second bone, and a second anchor having a second threaded region configured to be secured into the second bone, wherein the second anchor is configured to be secured to the second implant. 149-. (canceled)50. A joint replacement system for repairing a first and a second articular surface corresponding to a first and a second oppositely arranged bone , respectively , said system comprising: [ a first implant body including a first load bearing surface having a contour defining a generally hemispherical ball; and', 'a support plate configured to be secured to said first implant body using a first tapered connection therebetween; and, 'a first implant comprising, 'a first anchor configured to be secured into said first bone, wherein said first anchor is configured to be secured to said first implant body using a second tapered connection therebetween, 'a first implant system comprising51. The joint replacement system of claim 51 , further including a second implant system claim 51 , said second implant system comprising:a second implant including a second load bearing surface having a contour defining a socket configured to articulate against said first load bearing surface; anda second anchor configured to be secured into said second bone, wherein said second anchor is configured to be removably secured to said second implant.52. The joint replacement system of claim 51 , wherein said first ...

SHEATHS FOR IMPLANTABLE FIXATION DEVICES

Sheaths for implantable fixation devices are disclosed. Sheaths have a flexible body with a perforated wall, an open end, a closed end, and a body interior sized and shaped to receive the fixation device. 118-. (canceled)34. A sheath for an implantable fixation device , the sheath comprising:a flexible body having a relieved wall, the body defining an interior sized and shaped to receive the fixation device and including an open end and a closed end.35. The sheath of claim 34 , wherein the body defines a tube claim 34 , the tube being sized and shaped to receive the fixation device.36. The sheath of claim 35 , wherein the tube is sized and shaped to snugly receive a shaft of a bone screw fixation device.37. The sheath of claim 34 , wherein the relieved wall comprises a mesh wall.38. The sheath of claim 34 , wherein the flexible body comprises a tube that defines at least one perforation in a circumferential side wall of the tube.39. The sheath of claim 34 , wherein the flexible body includes an interior that is flexible such that claim 34 , when the fixation device is inserted into the body claim 34 , the body flexibly expands to allow the fixation device to fit snugly within the body.40. The sheath of claim 34 , wherein the body defines a tube and the threads are longitudinally aligned with a central axis of the tube.41. The sheath of claim 34 , wherein the body defines a tube and the mesh wall includes additional threads that are perpendicular to a central axis of the tube.42. The sheath of claim 34 , wherein the body is made from a bioabsorbable material.43. The sheath of claim 42 , wherein the shaft of the bone screw fits snugly within the interior of the sheath.44. The sheath of claim 42 , wherein the shaft includes generally rounded screw threads.45. The sheath of claim 42 , wherein the body defines a tube claim 42 , the tube being sized and shaped to receive the fixation device.46. The sheath of claim 42 , wherein the relieved wall comprises a mesh wall.47. ...

Canard stowage lock

A canard deployment mechanism includes a canard connected to a shaft that is hingedly attached to a rotatable hub that is moveable between a stowed and deployed position. The mechanism further includes a locking feature on the canard for restraining the canard in the stowed position. In an embodiment the mechanism further includes a pawl rotatably mounted on a drive gear to contact and restrain the canard in the stowed position.

Trochlear Resurfacing System and Method

A system for repairing a defect on an articular surface of a patient's trochlear region, the system comprising a guide block comprising a body having an exterior surface configured to engage with the saddle portion and ridge portions of the patient's trochlear region, a protrusion extending generally from the body and configured to be received in a first bore formed in the articular surface along a reference axis, and a first cavity extending through the body configured to establish a first working axis displaced from the reference axis, wherein the exterior surface of the body and the protrusion are configured to secure the location of the guide block about the patient's trochlear region. A method for preparing an implant site in bone, comprising: establishing a reference axis extending from the bone; creating a bore in the bone by reaming about the reference axis; securing a guide block about the articular surface; establishing a first working axis extending from the bone using the guide block, the first working axis is displaced from the reference axis; and creating a first socket in the bone by reaming about the first working axis, wherein the first socket partially overlaps with the bore. 1. A method for preparing an implant site in bone , comprising:establishing a reference axis extending from said bone;creating a bore in said bone by reaming about said reference axis;securing a guide block about said articular surface;establishing a first working axis extending from said bone using said guide block, said first working axis is displaced from said reference axis; andcreating a first socket in said bone by reaming about said first working axis, wherein said first socket partially overlaps with said bore.2. The method of claim 1 , wherein said guide block comprises a body including a base portion and sidewall portions having a generally arcuate shaped exterior surface generally configured to engage with the saddle portion and ridge portions of a patient's ...

Retrograde Resection Apparatus and Method

A retrograde resection apparatus may include a cutting blade including a slot defined in the cutting blade, a recess defined in at least a portion of the slot, a screw, including a proximal end and a distal end defining a bore therethrough, a shaft having a distal end and a proximal end, wherein the shaft passes through the bore and the distal end is configured to be received in the recess, and a biasing device configured to bias the shaft against the cutting blade. In addition, the apparatus may include a tether, a first portion of which is affixed to the cutting blade and a second portion of which passes through the bore. 1. A retrograde resection apparatus , comprising:a cutting blade having a body defining a first surface and a second surface, including at least one cutting feature provided on said second surface;a slot defined through at least a portion of said body;a recess defined in at least a portion of said slot;a shaft having a distal end and a proximal end, wherein a portion of said distal end is received in said recess; anda biasing device configured to bias said shaft against said cutting blade.2. The apparatus of claim 1 , further comprising:a hemispherical protrusion extending from said distal end of said shaft, wherein said protrusion is configured to be at least partially received in said recess.3. The apparatus of claim 1 , wherein at least a portion of said distal end of said shaft is configured to be received in said slot.4. The apparatus of claim 1 , further comprising a screw claim 1 , including a proximal end and a distal end defining a bore therethrough claim 1 , received on said shaft.5. The apparatus of claim 4 , wherein said shaft is rotatable in said bore.64. The apparatus of claim 4 , wherein said screw includes a nut on said proximal end7. The apparatus of claim 4 , wherein said screw includes a plurality of continuous threads in a central portion and a tap proximate said distal end.8. The apparatus of claim 1 , further comprising:a ...

Glenoid Resurfacing System and Method

The present disclosure relates to a system and method for repairing an articular surface. A guide pin may be secured to an articular surface of a glenoid, wherein the guide pin defines a working axis and the working axis is positioned at an angle α relative to the articular surface, wherein angle α is less than or equal to 90 degrees. An excision device may be advanced over the guide pin, wherein the excision device includes a cannulated shaft and at least one cutter, wherein the at least one cutter is generally aligned in a single plane. A generally hemi-spherical excision site may be formed with the excision device within the articular surface of the glenoid. 1. A method for repairing a defect on a portion of an articular surface of a patient's glenoid , said method comprising:securing a guide pin to said articular surface of said glenoid proximate to said defect, wherein said guide pin defines a working axis and said working axis is positioned at an angle α relative to the articular surface, wherein angle α is less than or equal to 90 degrees;advancing an excision device over said guide pin, wherein said excision device includes a cannulated shaft and at least one cutter extending radially outwardly from said cannulated shaft, wherein said at least one cutter is generally aligned in a single plane extending along a longitudinal axis of said cannulated shaft; androtating said excision device about said guide pin to form a generally hemi-spherical excision site within the articular surface of the glenoid around said guide pin.2. The method of claim 1 , wherein said guide pin is configured to be disposed at an angle α relative to the articular surface claim 1 , wherein 90 degrees≥α≥45 degrees.3. The method of claim 1 , further comprising removing said guide pin and placing an implant in said excision site.4. The method of claim 1 , wherein said defect is disposed proximate to a perimeter of said articular surface and wherein said excision site extends to said ...

ARTICULAR SURFACE IMPLANT SYSTEMS AND METHODS INCLUDING GLENOID REVERSE SHOULDER

The present disclosure provides an implant system. The implant system includes an anchor configured to be secured to bone within an excision site formed in a patients glenoid, said anchor including a shank and an enlarged head. The implant system also includes a baseplate including a body comprising: a bone facing surface; an implant facing surface; and a channel configured to extend radially from an entrance in an outer periphery of said body to a central region of said baseplate, said channel configured to receive said enlarged head and a portion of said shank and including an open region formed, at least in part, in said bone facing surface. The implant system also includes an implant including a body defining a load bearing surface and a baseplate recess, said baseplate recess configured to receive at least a portion of said implant facing surface to said baseplate such that said implant is coupled to said baseplate. 1. An implant system comprising:an anchor configured to be secured to bone within an excision site formed in a patient's glenoid, said anchor including a shank and an enlarged head; a bone facing surface;', 'an implant facing surface; and', 'a channel configured to extend radially from an entrance in an outer periphery of said body to a central region of said baseplate, said channel configured to receive said enlarged head and a portion of said shank and including an open region formed, at least in part, in said bone facing surface; and, 'a baseplate including a body comprisingan implant including a body defining a load bearing surface and a baseplate recess, said baseplate recess configured to receive at least a portion of said implant facing surface to said baseplate such that said implant is coupled to said baseplate.2. The implant system of claim 1 , wherein said load bearing surface has a generally hemispherical shape.3. The implant system of claim 1 , wherein said implant comprises a glenosphere.4. The implant system of claim 1 , wherein said ...

MULTICOMPONENT ARTICULAR SURFACE IMPLANT

A multicomponent implant system includes a multicomponent implant comprising a base plate and a load plate. The base plate includes a bone facing surface and a base plate interface surface. The load plate includes a load plate interface surface and a load bearing surface, the load bearing surface being substantially parallel to the load plate interface surface and having a contour substantially corresponding to a contour of a removed portion of the articular surface. Both the load plate interface surface and base plate interface surface have a contour substantially corresponding to the contour of the load bearing surface. The load plate is configured to be advanced in an arcuate direction to slidably couple the load plate to the base plate after the base plate has been secured within the first excision site by an anchor. 1. An implant system comprising: [ ["a load plate comprising a load bearing surface and a load plate interface surface, wherein said load bearing surface has a contour substantially corresponding to a contour of a removed portion of a patient's articular surface of a first bone, and wherein said load plate interface surface has a contour along said first axis that substantially corresponds to the contour of the load bearing surface along said first axis; and", "a base plate comprising a bone facing surface and a base plate interface surface, said bone facing surface configured to engage said first bone within a first excision site beneath said removed portion of said patient's articular surface, and said base plate interface surface having a contour along said first axis that substantially corresponds to the contour of the load plate interface surface along said first axis; and"], 'a multicomponent implant having a proximal end and a distal end and a first axis extending therebetween when assembled, said multicomponent implant comprising, 'a multicomponent implant anchor configured to be secured to said first bone and to secure said base plate ...

APPARATUS FOR TISSUE REPAIR

An apparatus includes first and second fixation members, a flexible member coupled to the first and second fixation members, and a limiting element coupled to the flexible member. The limiting element is movable relative to the second fixation member and acts to limit loosening of the flexible member relative to the second fixation member. The limiting element can be slidably received by the flexible member. The flexible member can be coupled to the fixation members such that pulling on a free end of the flexible member shortens a length of the flexible member between the fixation members. 120-. (canceled)21. A tissue repair device , comprising:first and second fasteners, the first and second fasteners having an elongated main body and a projection extending from the main body;a flexible member coupling the projections of the first and second fasteners, the flexible member including a limiting element between the first and second fasteners, such that tensioning an end of the flexible member shortens a length of the flexible member between the first and second fasteners; and a handle;', 'a cannula extending from the handle and including a longitudinal opening in the cannula along at least a portion of the length of the cannula; and', 'a pusher member slidably positioned within the cannula, the pusher member including a finger-engageable element for advancing the pusher member within the cannula;, 'a delivery device comprisingwherein the first and second fasteners are slidably disposed within the cannula such that, upon advancement of the pusher member, at least one of the first and second fasteners is deployed from the cannula; andwherein, after the at least one of the first and second fasteners is deployed from the cannula, the at least one of the first and second fasteners is configured to rotate in response to the tensioning of the end of the flexible member.22. The device of claim 21 , wherein the first and second fasteners have substantially the same shape.23. ...

System and method for joint resurfacing and repair

An implant resection system for preparing an implant site to replace a defect in an articular surface of a first bone includes a first guide configured to be coupled generally to the first bone. The first guide includes a body portion defining a channel configured to receive a pin, wherein the pin is configured to penetrate and form a longitudinally disposed bore within the first bone. The implant resection system further includes a second guide configured to be coupled generally perpendicular to the first bone proximate to the defect by way of the bore. The second guide includes a drill bit configured to form an excision site through a portion of the articular surface in preparation of receipt of an implant.

MOLDS FOR FORMING DERMAL ALLOGRAFT IMPLANTS AND DERMAL ALLOGRAFT IMPLANTS FORMED FROM SAME

The present disclosure includes devices, apparatuses, and methods for forming lyophilized soft-tissue allografts for the correction of skeletal impairments (e.g., misalignments, arthritis, etc.), and soft-tissue allograft implants formed from the same. 1. A mold for forming lyophilized allograft implants , comprising:a body having a first side and a second side and defining a chamber for receiving an allograft tissue, the chamber having a periphery extending between and through the first side and the second side;a first end cap configured to be coupled to the first side of the body over the chamber, the first end cap having a body-facing side with a surface portion that is aligned with the chamber when the first end cap is coupled to the body, and an outer side defining a plurality of holes extending between and through the outer side and the body-facing side and in fluid communication with the surface portion of the first end cap; anda second end cap configured to be coupled to the second side of the body over the chamber, the second end cap having a body-facing side with a surface portion that is aligned with the chamber when the second end cap is coupled to the body, and an outer side defining a plurality of holes extending between and through the outer side and the body-facing side and in fluid communication with the surface portion of the second end cap.2. The mold of claim 1 , where the body claim 1 , having a first portion and a second portion claim 1 , defines the chamber when the first portion and the second portion are coupled together.3. The mold of claim 1 , where the first end cap and the second end cap are coupled to the body to compress and form the allograft tissue into a shape conforming to the chamber during lyophilization claim 1 , and/or the first portion and the second portion of the body are coupled to compress and form the allograft tissue into a shape conforming to the chamber during lyophilization.4. The mold of claim 1 , where the chamber ...

Net shape moldable thermally conductive materials

A method of making a heat exchanger with a net shape moldable highly thermally conductive polymer composite includes mixing a polymer and a thermally conductive filler material and molding the polymer composite into heat exchanger components. The heat exchanger can be tailored to varying heating and cooling needs with moldable geometries.

System and Method for Joint Resurface Repair

A system for repairing a defect on a patient's articular surface comprising a guide, a guide pin, a reamer, and an implant. The guide is configured to be disposed about the defect and includes a passageway configured to establish a reference axis extending generally outwardly from the articular surface. The guide pin is configured to be received through the guide passageway along the reference axis and into bone beneath the articular surface. The reamer comprises a cannulated shaft configured to be advanced over the guide pin along the reference axis and further comprises a cutting surface configured to be rotated about the guide pin to form an excision site. The implant comprises a bone facing surface configured to be received in the excision site and a load bearing surface having a contour approximating a contour of the patient's articular surface. 1. A system for repairing a defect on a patient's articular surface , said system comprising:a guide configured to be disposed about said defect, said guide comprising a passageway configured to establish a reference axis extending generally outwardly from said articular surface proximate to said defect;a guide pin configured to be received through said passageway of said guide along said reference axis and into bone beneath said articular surface;a reamer comprising a cannulated shaft configured to be advanced over said guide pin along said reference axis, said reamer further comprising a cutting surface configured to be rotated about said guide pin to form an excision site; andan implant comprising a bone facing surface configured to be received in said excision site and a load bearing surface having a contour approximating a contour of said patient's articular surface.2. The system of claim 1 , wherein said reamer defines a generally circular excision path as said reamer is rotated about said guide pin to form a generally circular excision site.3. The system of claim 2 , wherein said reamer includes a radius ...

HUMERAL AND GLENOID ARTICULAR SURFACE IMPLANT SYSTEMS AND METHODS

A shoulder implant system comprising a glenoid implant; a baseplate comprising an implant facing surface to face the glenoid implant; wherein the glenoid implant comprises at least one fixation element configured to engage with at least one fixation element of the baseplate; wherein the at least one fixation element of the glenoid implant comprises a center post having a distal end; wherein the at least one fixation element of the baseplate comprises a center post receptacle; wherein the baseplate comprises an outer periphery; wherein the implant facing surface of the baseplate comprises a channel which extends from the outer periphery of the baseplate to the center post receptacle of the baseplate; and wherein the channel is configured such that, during an assembly of the glenoid implant and the baseplate, the distal end of the post is movable in the channel from the outer periphery of the baseplate to the center post receptacle of the baseplate. 1. A shoulder implant system comprising:a glenoid implant;a baseplate comprising an implant facing surface to face the glenoid implant;wherein the glenoid implant comprises at least one fixation element configured to engage with at least one fixation element of the baseplate;wherein the at least one fixation element of the glenoid implant comprises a center post having a distal end;wherein the at least one fixation element of the baseplate comprises a center post receptacle;wherein the baseplate comprises an outer periphery;wherein the implant facing surface of the baseplate comprises a channel which extends from the outer periphery of the baseplate to the center post receptacle of the baseplate; andwherein the channel is configured such that, during an assembly of the glenoid implant and the baseplate, the distal end of the post is movable in the channel from the outer periphery of the baseplate to the center post receptacle of the baseplate.2. The shoulder implant system of wherein the system further comprises a plug ...

Suture System and Method

A suture system including a suture construct having a first reduction construct configured to be selectively arranged in an expanded state and a reduced state. The first reduction construct includes a first locking limb, a first contractible loop, and a first opposed loop disposed generally opposite to the first contractible loop, wherein reduction of the first opposed loop contracts the first contractible loop from the expanded state into the reduced state and secures the suture construct in the reduced state. The suture construct may also include a second reduction construct. Optionally, the suture system includes a first and a second pusher tube defining a first and a second lumen, respectively, wherein each pusher tubes are advanced over portions of opposed loops, respectively, and wherein distal portions of opposed loops extend beyond the pusher tubes, respectively. 1. A suture system comprising: a first locking limb;', 'a first contractible loop; and', 'a first opposed loop disposed generally opposite to said first contractible loop, wherein reduction of said first opposed loop contracts said first contractible loop from said expanded state into said reduced state and secures said suture construct in said reduced state., 'a suture construct including a first reduction construct configured to be selectively arranged in an expanded state and a reduced state, said first reduction construct comprising2. The suture system of claim 1 , further comprising a suture pin configured to be disposed through said first contractible loop.3. The suture system of claim 2 , wherein said suture pin includes an elongated main body having a generally circular cross-section extending between a first and a second enlarge portion claim 2 , said first and said second enlarge portions extending outwardly from said elongated main body.4. The suture system of claim 3 , wherein said first and said second enlarge portions include a generally concaved bone facing surface.5. The suture ...

APPARATUS FOR TISSUE REPAIR

An apparatus includes first and second fixation members, a flexible member coupled to the first and second fixation members, and a limiting element coupled to the flexible member. The limiting element is movable relative to the second fixation member and acts to limit loosening of the flexible member relative to the second fixation member. The limiting element can be slidably received by the flexible member. The flexible member can be coupled to the fixation members such that pulling on a free end of the flexible member shortens a length of the flexible member between the fixation members. 120-. (canceled)21. A wound closure device comprising:an elongate first fastener and an elongate second fastener, each of the first and second fasteners defining first and second through holes for receiving a flexible member, each of the first and second through holes extending from a first surface to a second surface opposite the first surface transverse to a longitudinal axis of each of the first and second fasteners;a needle having an open distal end and a tissue-piercing tip, an inner surface of the needle defining a lumen extending to and in communication with the open distal end, the lumen being configured to receive at least one of the first and second fasteners;a handle coupled to the needle at a distal end of the handle;a pusher positioned within the lumen of the needle and actuatable at the handle for distally advancing at least one of the first and second fasteners within the lumen;wherein the flexible member is fixedly attached to the first fastener and moveably coupled to the second fastener, the flexible member including a limiting element between the first and second fasteners, such that pulling on an end of the flexible member shortens a length of the flexible member between the first and second fasteners.22. The device of claim 21 , wherein the first and second fasteners have substantially the same shape.23. The device of claim 21 , wherein the limiting element is ...

Delivery System for Articular Surface Implant

A implant delivery system for securing an implant to an anchor. The implant delivery system includes a driver including a shaft, a biasing body having a first end region configured to engage said driver and a second end region configured to engage a portion of an implant, and a suture extending between the anchor and the shaft of the driver. The driver may be rotated to reduce the length of the suture between the driver and the anchor and generate a biasing force urging the implant into engagement with the anchor. The biasing force is substantially not transmitted to the bone. 1. A delivery system for securing an implant with an anchor , the delivery system comprising:a driver including a shaft, said driver configured to wind a portion of a suture, said suture configured to extend around a contact portion of said anchor disposed within a bone; anda biasing body having a first end region including a driver cradle configured to generally retain a portion of said shaft as said driver is rotated relative to said biasing body, and a second end region configured to engage a portion of said implant;wherein rotation of said driver applies a biasing force against said implant and said anchor to secure said implant with said anchor, and wherein said biasing force is substantially not transmitted to said bone.2. The delivery system of claim 1 , further comprising said suture claim 1 , wherein said suture includes a first region configured to be generally secured to said shaft and a second region configured to be disposed about said contact portion of said anchor.3. The delivery system of claim 2 , wherein said second region of said suture includes a first and a second portion defining a cradle configured to engage said contact portion of said anchor.4. The delivery system of claim 3 , wherein said biasing body is configured to maintain a separation angle of said first and second portions of said cradle.5. The delivery system of claim 1 , wherein said driver cradle includes an ...

Anchor for an Implant Assembly

A medical device includes an implant anchor comprising first and second opposing end portions. The implant anchor may also include a fixation element to configured to couple the implant anchor to an implant, and an anchor element configured to couple the implant anchor to bone. At least a portion of the implant anchor has a porous structure. 1. A medical device , comprising: a fixation element to configured to couple said implant anchor to an implant; and', 'an anchor element configured to couple said implant anchor to bone;, 'an implant anchor comprising first and second opposing end portions, said implant anchor further comprisingwherein at least a portion of said implant anchor has a porous structure.2. The medical device of claim 1 , wherein:said fixation element has a non-porous-structure.3. The medical device of claim 1 , wherein:said second end portion of said implant anchor comprises said anchor element; andat least a portion of said anchor element is formed by said porous structure.4. The medical device of claim 3 , wherein:said anchor element of said implant anchor comprises a threaded portion; andat least a portion of said threaded portion is formed by said porous structure.5. The medical device of claim 4 , wherein:said threaded portion of said implant anchor comprises a threaded shank; andat least a portion of said threaded shank is formed by said porous structure.6. The medical device of claim 5 , wherein:said threaded shank of said implant anchor comprises a screw thread;at least a portion of said screw thread is formed by said porous structure.7. The medical device of claim 5 , wherein:said threaded shank of said implant anchor comprises a screw thread;at least a portion of said screw thread is formed by a non-porous structure.8. The medical device of claim 5 , wherein:said threaded shank of said implant anchor comprises a shank root; andat least a portion of said shank root is formed by said porous structure.9. The medical device of claim 1 , ...

System and method for repairing articular surfaces

A total joint replacement system comprising a first and a second implant system. The first implant system includes a first implant having a first load bearing surface based on a first removed portion of an articular surface of a patient's first bone, and a first anchor having a first threaded region configured to be secured into the first bone, wherein the first anchor is configured to be secured to the first implant. The second implant system includes a second implant having a second load bearing surface based on a second removed portion of an articular surface of a patient's second bone, and a second anchor having a second threaded region configured to be secured into the second bone, wherein the second anchor is configured to be secured to the second implant.

IMPLANT AND ANCHOR ASSEMBLY

An implant assembly comprising an implant having a load bearing surface with a contour corresponding to a patient's articular surface, and a bone facing surface including a fixation element, an anchor configured to be secured to bone beneath said patient's articular surface, said anchor including a second fixation element, and wherein said first fixation element is configured to be secured to said second fixation element. 1. An implant assembly comprising:an implant having a load bearing surface with a contour corresponding to a patient's articular surface, and a bone facing surface including a first fixation element;an anchor configured to be secured to bone beneath said patient's articular surface, said anchor including a second fixation element; andwherein said first fixation element is configured to be secured to said second fixation element.2. The implant assembly of claim 1 , wherein:said implant comprises plastic; andsaid first fixation element and said second fixation element each comprise metal.3. The implant assembly of claim 1 , wherein:said implant comprises metal; andsaid first fixation element and said second fixation element each comprise plastic.4. The implant assembly of claim 1 , wherein:said first fixation element and said second fixation element are configured to mechanically connect with each other to form a mechanical connection therebetween.5. The implant assembly of claim 4 , wherein:said first fixation element and said second fixation element are further configured to frictionally engage with each other to form a frictional connection therebetween.6. The implant assembly of claim 5 , wherein:said first fixation element includes a tapered portion and said second fixation element includes a tapered portion; andsaid tapered portions are configured to frictionally engage with each other to form said friction connection therebetween.7. The implant assembly of claim 5 , wherein:said first fixation element comprises a tapered recess; andsaid second ...

Retrograde Resection Apparatus and Method

A retrograde resection apparatus may include a cutting blade including a slot defined in the cutting blade, a recess defined in at least a portion of the slot, a screw, including a proximal end and a distal end defining a bore therethrough, a shaft having a distal end and a proximal end, wherein the shaft passes through the bore and the distal end is configured to be received in the recess, and a biasing device configured to bias the shaft against the cutting blade. In addition, the apparatus may include a tether, a first portion of which is affixed to the cutting blade and a second portion of which passes through the bore. 1. A retrograde resection apparatus , comprising:a cutting blade having a body defining a first surface and a second surface, including at least one cutting feature provided on said second surface;a slot defined through at least a portion of said body;a recess defined in at least a portion of said slot;a shaft having a distal end and a proximal end, wherein a portion of said distal end is received in said recess; anda biasing device configured to bias said shaft against said cutting blade.2. The apparatus of claim 1 , further comprising:a hemispherical protrusion extending from said distal end of said shaft, wherein said protrusion is configured to be at least partially received in said recess.3. The apparatus of claim 1 , wherein at least a portion of said distal end of said shaft is configured to be received in said slot.4. The apparatus of claim 1 , further comprising a screw claim 1 , including a proximal end and a distal end defining a bore therethrough claim 1 , received on said shaft.5. The apparatus of claim 4 , wherein said shaft is rotatable in said bore.64. The apparatus of claim 4 , wherein said screw includes a nut on said proximal end7. The apparatus of claim 4 , wherein said screw includes a plurality of continuous threads in a central portion and a tap proximate said distal end.8. The apparatus of claim 1 , further comprising:a ...

CLOSURE DEVICE AND METHOD FOR TISSUE REPAIR

A method of closing a tissue wound includes providing a wound closure device having a first anchor, a second anchor, and a flexible member movably attached to the second anchor, positioning the first anchor against tissue, passing the flexible member across the wound, positioning the second anchor against tissue, and pulling on a free end of the flexible member to shorten a length of the flexible member between the first and second anchors, thereby closing the wound. A wound closure device includes a first anchor, a second anchor; and a flexible member connecting the first anchor to the second anchor, the flexible member being movably attached to the second anchor, such that pulling on a free end of the flexible member shortens a length of the flexible member between the first and second anchors. 1. A wound closure device comprising:a first anchor;a second anchor; anda flexible member connecting the first anchor to the second anchor, the flexible member being movably attached to the second anchor, such that pulling on a free end of the flexible member shortens a length of the flexible member between the first anchor and second anchor.2. The wound closure device of claim 1 , wherein the movable attachment of the flexible member to the second anchor enables the length of the flexible member between the first and second anchors to be shortened claim 1 , but not lengthened.3. The wound closure device of claim 2 , wherein the movable attachment includes a knot formed in the flexible member at the second anchor.4. The wound closure device of claim 3 , wherein the knot includes a first portion of the flexible member that forms a loop claim 3 , and a second portion that passes over a surface of the second anchor and through the loop.5. The wound closure device of claim 4 , wherein the surface comprises an exterior surface of the second anchor.6. The wound closure device of claim 4 , wherein the knot is configured such that pulling on the free end causes the flexible member ...

GLENOID REPAIR SYSTEM AND METHODS OF USE THEREOF

The present disclosure provides systems and methods for repairing a defect on a portion of an articular surface of a human body, particularly of the glenoid. More particularly, the present disclosure provides systems and methods for repairing both a glenoid cavity and a glenoid rim of the glenoid using a single implant. 1. A system for repairing a defect on at least a portion of an articular surface of a glenoid , said system comprising:at least two guide pins, said at least two guide pins comprising a first guide pin and a second guide pin, said first guide pin and said second guide pin configured to be secured to said glenoid;an excision apparatus comprising a guide body and an excision device;said guide body comprising a plurality of guide pin sleeves to contain said at least two guide pins, said plurality of guide pin sleeves comprising at least a first guide pin sleeve and a second guide pin sleeve; andwherein, when said first guide pin is contained in said first guide pin sleeve and said second guide pin is contained in said second guide pin sleeve, said guide body is retained in a first excision position for said excision device.2. The system of wherein:said guide body is slidable along said first guide pin and said second guide pin when said first guide pin is contained in said first guide pin sleeve and said second guide pin is contained in said second guide pin sleeve.3. The system of wherein:said first guide pin sleeve and said second guide pin sleeve are substantially parallel.4. The system of wherein:said first guide pin sleeve has a diameter substantially equal to a diameter of said first guide pin and said second guide pin sleeve has a diameter substantially equal to a diameter of said second guide such that, when said first guide pin is contained in said first guide pin sleeve and said second guide pin is contained in said second guide pin sleeve, said first guide pin and said second guide pin are substantially parallel.5. The system of wherein:said ...

SYSTEM AND METHOD FOR JOINT RESURFACING AND REPAIR

An implant resection system for preparing an implant site to replace a defect in an articular surface of a first bone includes a first guide configured to be coupled generally to the first bone. The first guide includes a body portion defining a channel configured to receive a pin, wherein the pin is configured to penetrate and form a longitudinally disposed bore within the first bone. The implant resection system further includes a second guide configured to be coupled generally perpendicular to the first bone proximate to the defect by way of the bore. The second guide includes a drill bit configured to form an excision site through a portion of the articular surface in preparation of receipt of an implant. 1. An implant resection system for preparing an implant site to replace a defect in an articular surface of a first bone , said implant resection system comprising:a first guide configured to be coupled to a first bone, said first guide comprising a body portion having at least one channel defined on a portion thereof, said channel configured to extend generally perpendicular to a portion of said first bone proximate to said defect; andat least one pin configured to be received and retained within said channel, said pin having a distal end configured to pierce said first bone and to extend and form a longitudinally disposed bore within said first bone.2. The implant resection system of claim 1 , further comprising:an arm extending outwardly from a distal face of said body portion of said first guide; anda spoon disposed about a distal end of said arm, said spoon configured to be disposed between said articular surface of said first bone and an articular surface of a second cooperating bone.3. The implant resection system of claim 2 , wherein said spoon further comprises a generally convex base portion configured to abut against said articular surface of said cooperating bone and a generally concave upper portion configured to abut against said articular surface ...

Heat resistant systems and methods

A veneer panel may comprise an outer surface, and a heat resistant system coupled to the outer surface comprising at least one of a thermal barrier layer or an intumescent layer.

System and Method for Bone Fixation

A fixation system for coupling a first and a second portion of bone together. The fixation system includes a first fixation element, a second fixation element, and an interconnect. The first fixation element includes an external surface configured to engage the first portion of bone and a first tapered mating surface. The second fixation element includes an external surface configured to engage the second portion of bone and a second tapered mating surface. The interconnect includes a first and a second tapered surface disposed at generally opposite ends. The first and the second tapered surfaces are configured to frictionally engage the first and the second tapered mating surfaces of the first and the second element, respectively, to form frictional interference connections therebetween. 1. A fixation system for coupling a first and a second bone together , said fixation system comprising:a first fixation screw having a tapered external surface configured to engage the first bone, the first fixation screw including a first tapered mating recess formed in one end of the first fixation screw;a second fixation screw having a tapered external surface to engage the second bone, the second fixation screw including a second tapered mating recess formed in one end of the second fixation screw; andan interconnect comprising a first and a second tapered surface disposed at generally opposite ends, said first and said second tapered surfaces to frictionally engage said first and said second tapered mating surfaces of said first and said second screws, respectively, to form frictional interference connections therebetween; and wherein the interconnect also including a flexible region formed between the first and second tapered surfaces to enable the first fixation screw to bend with respect to the second fixation screw.2. The fixation system of claim 1 , wherein the flexible region having cross-sectional dimension to provide a range of flexibility based on an original ...

HUMERAL AND GLENOID ARTICULAR SURFACE IMPLANT SYSTEMS AND METHODS

One embodiment of the present disclosure provides a humeral implant. The humeral implant includes a tray including a body defining a bone facing recess and a liner recess, said bone facing recess including a ring surface and a convex surface, wherein the ring surface has a profile substantially corresponding to a profile of an outer ring of bone in an excision site of a patient; and wherein said convex surface has a profile substantially corresponding to a profile of a concave socket formed in the excision site. The humeral implant also includes a liner including a body defining a load bearing surface and a tray interface surface, said tray interface surface being configured to be at least partially received in said liner recess of said tray such that said implant is coupled to said tray.

Suture System and Method

A suture system including a suture construct having a first reduction construct configured to be selectively arranged in an expanded state and a reduced state. The first reduction construct includes a first locking limb, a first contractible loop, and a first opposed loop disposed generally opposite to the first contractible loop, wherein reduction of the first opposed loop contracts the first contractible loop from the expanded state into the reduced state and secures the suture construct in the reduced state. The suture construct may also include a second reduction construct. Optionally, the suture system includes a first and a second pusher tube defining a first and a second lumen, respectively, wherein each pusher tubes are advanced over portions of opposed loops, respectively, and wherein distal portions of opposed loops extend beyond the pusher tubes, respectively. 1. A suture system comprising: a first locking limb;', 'a first contractible loop; and', 'a first opposed loop disposed generally opposite to said first contractible loop, wherein reduction of said first opposed loop contracts said first contractible loop from said expanded state into said reduced state and secures said suture construct in said reduced state., 'a suture construct including a first reduction construct configured to be selectively arranged in an expanded state and a reduced state, said first reduction construct comprising2. The suture system of claim 1 , further comprising a suture pin configured to be disposed through said first contractible loop.3. The suture system of claim 2 , wherein said suture pin includes an elongated main body having a generally circular cross-section extending between a first and a second enlarge portion claim 2 , said first and said second enlarge portions extending outwardly from said elongated main body.4. The suture system of claim 3 , wherein said first and said second enlarge portions include a generally concaved bone facing surface.5. The suture ...

Glenoid Resurfacing System and Method

The present disclosure relates to a system and method for repairing an articular surface. A guide pin may be secured to an articular surface of a glenoid, wherein the guide pin defines a working axis and the working axis is positioned at an angle α relative to the articular surface, wherein angle α is less than or equal to 90 degrees. An excision device may be advanced over the guide pin, wherein the excision device includes a cannulated shaft and at least one cutter, wherein the at least one cutter is generally aligned in a single plane. A generally hemi-spherical excision site may be formed with the excision device within the articular surface of the glenoid.

BONE SCREWS WITH ENHANCED FATIGUE RESISTANCE AND RELATED KITS AND METHODS

The present bone screws—and kits and methods utilizing such bone screws—provide enhanced fatigue resistance (EFR), increased fixation strength, and/or improved tactile feedback. The enhanced fatigue resistance can increase the working life of a bone screw and reduce the possibility of a bone screw cracking or breaking and possible adverse implications thereof. The improved tactile feedback can improve usability by maintaining a level friction and resistance (during insertion of the screws into bone) that is familiar to health care providers. The present bone screws, kits, and methods may be configured and/or implemented for use in the repair of cancellous and/or cortical bone. 1. A bone-screw , comprising:an elongated shank extending from a proximal end to a distal tip, where the shank defines one or more threads along at least a portion of a length of the shank;a head coupled to the proximal end of the shank, the head having a transverse dimension that is larger than a corresponding transverse dimension of the proximal end of the shank; anda Type II (e.g., per AMS 2488 for titanium and its alloys) anodized surface layer on the shank.2. The bone screw of claim 1 , where the anodized surface layer extends over the head and/or is roughened over at least part of the thread(s).3. The bone screw of claim 1 , where the head is unitary with the shank and defines a recess configured to receive a driver claim 1 , or the head is unitary with a single use driver that is configured to be broken or otherwise separated from the head after the screw is inserted into bone.4. The bone screw of claim 1 , where the threads are configured as self-tapping and/or self-drilling helical thread(s).5. The bone screw of claim 4 , where the shank defines a longitudinal claim 4 , self-tapping notch extending through a portion of the helical thread(s) from the distal tip toward the proximal head.6. The bone screw of claim 1 , where the shank defines a longitudinal channel extending through the ...

SYSTEMS AND METHODS FOR SIZING AND INTRODUCTION OF SOFT-TISSUE ALLOGRAFTS

The present disclosure includes systems, methods, kits, and individual tools (e.g., trial sizers and delivery devices) for medical procedures involving a soft-tissue allograft for the correction of skeletal impairments (e.g., misalignments, arthritis, etc.). 1. A trial sizer comprising:a cylindrical head having a first side, a second side, and a peripheral surface extending between the first and second sides and defining a circular cross sectional shape of the head;a handle having a proximal end and a distal end coupled to the peripheral surface; andwhere the head has dimensions that mimic the dimensions of a corresponding soft-tissue allograft.2. The trial sizer of claim 1 , where the head is radiopaque.3. The trial sizer of claim 1 , where a transverse dimension of the head is from 8 mm to 20 mm.4. An apparatus for delivering an insert into a space between a patient's bones claim 1 , the apparatus comprising: an elongated shaft having a proximal end and a distal end; and', 'a radiopaque tip coupled to the distal end of the elongated shaft, the tip having a transverse dimension equal to or greater than a corresponding transverse dimension of the elongated shaft, and having dimensions that mimic the dimensions of a corresponding soft-tissue allograft., 'a trial sizer, comprising5. The apparatus of claim 4 , where the elongated shaft of the trial sizer defines a channel extending from the proximal end to the distal end.6. The apparatus of claim 5 , where the elongated shaft is configured to indicate insertion depth.7. The apparatus of claim 4 , further comprising:a delivery cannula comprising:an elongated body having a proximal end and a distal end, and defining a longitudinal channel extending between and through the proximal and distal ends; anda handle portion coupled to the proximal end of the elongated body, the handle portion defining a channel that is aligned with and in fluid communication with the longitudinal channel of the elongated body.8. The apparatus ...

Methods and systems for monitoring a temperature of a component during a welding operation

A method of monitoring a heating operation on an component by a flame torch, including the steps of producing a flame with the flame torch, rotating the component with respect to the flame so that a circular weld is created on the component, and providing a first sensor that is operatively engaged with the component so that the first sensor monitors rotation or non-rotation of the components.

Inhibitors of hepatitis c virus replication

The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

Deinking of waste paper

Waste paper can be deinked by use of a composition which comprises a surfactant and a mineral-based deinking component.

Reactor distribution apparatus and quench zone mixing apparatus

A quench zone mixing apparatus is supported within a vessel of a reactor by a support structure that includes a concentric hub, which may be formed to act as a torsion tube, and at least a first set of radial beams extending radially outward from the hub and terminating at a support ring that is attached to the reactor vessel wall. In particular, the radial beams comprise a flange that supports the redistribution tray and a web of the beams preferably includes a plurality of openings to allow the passage of fluids across the vessel. In addition, the webs also carry the channels. The radial beams also support the mixing chamber and, in the area between the wall of the mixing chamber and the vessel wall, the radial beams may have a vertical height that slopes downward from the vessel wall to the mixing chamber wall.

High internal phase emulsions (HIPEs) and foams made therefrom

High internal phase emulsions (HIPEs), porous polymeric materials made therefrom, and methods for making and using the same. Specific embodiments of the invention include water-in-oil high internal phase emulsions having at least 70 volume percent of an internal aqueous phase and less than 30 volume percent of an external oil phase wherein the oil phase comprises a vinyl polymerizable monomer and a surfactant effective to stabilize the emulsion. The subject surfactants are oil soluble and preferably include an oxyalkylene component.

Magnetic filtration devices and methods related thereto

In vivo and ex vivo positionable magnetic filtration devices are provided that magnetically filter one or more therapeutic agents conjugated to a magnetic particle in blood flowing in a blood vessel.

Streamlined unobstructed one-pass axial-flow pump

A blood pump has an impeller rotatably disposed and magnetically suspended within a cavity of a stator by a plurality of magnetic bearings (passive permanent and active electromagnetic) having impeller magnets on the impeller and stator magnets or coils/poles on the stator. A motor includes impeller magnets on the impeller and coils/poles associated with the stator. A single, annular blood flow path extends axially through the cavity between the impeller and the stator, and between the impeller magnets on the impeller and the stator magnets or the coils/poles on the stator.

Axial-flow blood pump with magnetically suspended, radially and axially stabilized impeller

A blood pump (10) has an impeller (14) rotatably disposed and magnetically suspended within a cavity (22) of a stator (18) by a plurality of magnetic bearings (40, 50, 60) including an axial bearing (40) to support the impeller axially in the cavity. The axial bearing includes adjacent impeller magnets (44a, b & c) and adjacent stator magnets (42a, b & c) with axially aligned polarities and reverse polarities with respect to adjacent magnets. A motor (150) includes impeller magnets (154) on the impeller and coils and poles (158, 162) associated with the stator. Radial permanent magnet and electromagnetic bearings (50, 60) are also included. The magnetic bearings and the motor have stator magnets or coils and poles disposed radially across the fluid passage from corresponding impeller magnets to define an annular gap positioned radially between the impeller and the stator, and positioned radially between all of the plurality of magnetic bearings, creating a straight through blood path without secondary flow paths.

Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors

Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X 1 , X 2 , X 3 and X 4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including diseases or disorders mediated by a RET kinase.

System and method for joint resurface repair

A generic bone implant, or set of standardized implants, is created based on using a guide device to develop an axis normal to an articular surface of bone and collecting only one or two data points. A generic cutting tool is used to cut the bone to a point where a generic implant can be used. Several improved tools relating to the procedure for using such an implant, as well as methods for using implants consistent with the invention are further described, including: single-axis and biaxial drill guide tools and methods, generic single-axis implant methods and devices, generic biaxial implant methods and devices, tools and methods for holding or delivering an implant, removal or revision tools and methods, digital measuring systems and methods, and set of measuring gauges for determining the appropriate implant dimensions.

System and method for joint resurface repair

An implant comprising a first, second, and third segment wherein the second and third segments partially overlap the first segment and define a load bearing surface comprising an anterior-posterior (AP) curvature including at least two tangential curves of the portion of the articular surface of the femoral condyle, the tangential curves having different radii of curvature. A drill guide comprises a body portion including a first, second and third bushing spaced along the body portion to establish a first, second and third axes, respectively. Each axis may be substantially normal to the articular surface at three different points along a curvature of the articular surface comprising the two tangential curves. A measuring device comprises a housing defining a longitudinally passageway and an outrigger. A guide pin may be received in the longitudinal passageway and a measuring device determines how far the guide pin is in the passageway.

Retrograde delivery of resurfacing devices

A method according to one embodiment may provide access to an articular surface of a bone. The method includes forming a passage through at least a portion of the bone. The passage provides an opening in the articular surface. The method further includes inserting a tether through the passage. The tether inserted through the passage can be coupled to at least one device from an insertion site remote from the articular surface. The tether can be withdrawn through the passage to convey the device to a location proximate the articular surface.

System and method for joint resurface repair

The present invention provides tools and methods for mapping and measuring the articular surface of a joint (or of any bony surface) and for fabricating a prosthetic device based on this recorded data. In one embodiment, once the defect of the chondral surface has been identified, a guide pin is inserted arthroscopically. A fixation screw is driven into the subchondral bone in relation to a reference axis that is approximately central to the defect, the fixation device also serving to define a tangent point to the surrounding articular surface. A further cylindrical proximal extension of the screw that eventually serves as a fixation element for the surface prosthetic is concealed with a cover or plug. The depth positioning of the cover or plug establishes an origin or reference point for all future measuring, cutting, and prosthetic machining operations. A measuring tool having a static post that establishes the axial location of origin is inserted on the reference axis. By rotating the outer arm or outrigger of the measuring tool relative to the static post while also maintaining contact with the articular surface, an axial displacement or Z dimension is established relative to the origin for any point along the known radial sweep of the outrigger to determine the final geometry of the prosthetic surface which fits within the defect. Data recorded during the mapping procedure is entered into parametric engineering design software or similar algorithm to define a three dimensional surface matched to the bearing surface geometry to be implanted and reproduce the anatomic contours mapped.

Trochlear resurfacing system and method

A system for repairing a defect on an articular surface of a patient's trochlear region, the system comprising a guide block comprising a body having an exterior surface configured to engage with the saddle portion and ridge portions of the patient's trochlear region, a protrusion extending generally from the body and configured to be received in a first bore formed in the articular surface along a reference axis, and a first cavity extending through the body configured to establish a first working axis displaced from the reference axis, wherein the exterior surface of the body and the protrusion are configured to secure the location of the guide block about the patient's trochlear region. A method for preparing an implant site in bone, comprising: establishing a reference axis extending from the bone; creating a bore in the bone by reaming about the reference axis; securing a guide block about the articular surface; establishing a first working axis extending from the bone using the guide block, the first working axis is displaced from the reference axis; and creating a first socket in the bone by reaming about the first working axis, wherein the first socket partially overlaps with the bore.

System and method for retrograde procedure

A system and method may be used for accessing an articular surface and for preparing an implant site on the articular surface. The method may include locating a portion of the articular. An access passage may be drilled towards the articular surface though bone behind the articular surface. An implant site may be excised in the articular surface relative to an axis defined by the access passage.

System for articular surface replacement

A system for replacing a portion of an articular surface including providing an implant site and installing an implant into the implant site. The implant site includes a first and a second excision site which at least partially intersect with one another. Each of the first and second excision sites are formed by providing a respective axis and excising a portion of the articular surface relative to the respective axes.

Articular surface implant and delivery system

A method is provided for delivering an implant for replacing a portion of an articular surface. The method may include forming a socket in an articulating feature that is capable of moving relative to the articular surface. An implant may be placed in the socket and the articulating feature may be moved relative to the articular surface to generally align the socket with an implant site formed in the articular surface. The implant may be transferred from the socket into the implant site.

Retrograde resection apparatus and method

Bone resurfacing system and method

Glenoid resurfacing system and method

The present disclosure relates to a system and method for repairing an articular surface. A guide pin may be secured to an articular surface of a glenoid, wherein the guide pin defines a working axis and the working axis is positioned at an angle α relative to the articular surface, wherein angle α is less than or equal to 90 degrees. An excision device may be advanced over the guide pin, wherein the excision device includes a cannulated shaft and at least one cutter, wherein the at least one cutter is generally aligned in a single plane. A generally hemi-spherical excision site may be formed with the excision device within the articular surface of the glenoid.

Glenoid repair system and methods of use thereof

The present disclosure provides systems and methods for repairing a defect on a portion of an articular surface of a human body, particularly of the glenoid. More particularly, the present disclosure provides systems and methods for repairing both a glenoid cavity and a glenoid rim of the glenoid using a single implant.

Glenoid resurfacing system and method

A system and method for repairing a defect on an articular surface. An excision guide is positioned on an articular surface, wherein the excision guide includes a guide head and a guide sleeve disposed on the guide head, wherein the guide head includes a contact surface configured to locate the excision guide relative to the articular surface. A guide pin may be advanced through the guide sleeve and secured to the articular surface, wherein the guide sleeve is configured to receive the guide pin therethrough and position the guide pin at an angle relative to an axis generally normal and central to a defect on the articular surface, wherein angle is less than 90 degrees.

Tibial resurfacing system and method

An implant resection system for preparing an implant site to replace a defect in an articular surface of a first bone includes a guide configured to be coupled generally perpendicular to the first bone proximate to the defect. The guide includes a body portion defining a plurality of excision passageways. The excision passageways each define a generally cylindrical core pathway configured to extend generally perpendicular to the first bone which partially overlaps with an adjacent generally cylindrical core pathway. A projection associated with each of the plurality of the generally cylindrical core pathways defines a truncated cylindrical excision site extending through a portion of the articular surface. Each truncated cylindrical excision site partially overlaps with at least one adjacent truncated cylindrical excision site.

Suture coil and suture sheath for tissue repair

A medical device is provided comprising a suture thread coated with a stiffening agent and having a shape of a coil having a plurality of windings. The suture thread may be used to reconnect soft tissue to bone tissue. The suture thread may be used in conjunction with a suture sheath which is inhibited from movement relative to the suture thread.

System and method for joint resurfacing and repair

An implant resection system for preparing an implant site to replace a defect in an articular surface of a first bone includes a first guide configured to be coupled generally to the first bone. The first guide includes a body portion defining a channel configured to receive a pin, wherein the pin is configured to penetrate and form a longitudinally disposed bore within the first bone. The implant resection system further includes a second guide configured to be coupled generally perpendicular to the first bone proximate to the defect by way of the bore. The second guide includes a drill bit configured to form an excision site through a portion of the articular surface in preparation of receipt of an implant.

Suture system and method

A suture system including a suture construct having a first reduction construct configured to be selectively arranged in an expanded state and a reduced state. The first reduction construct includes a first locking limb, a first contractible loop, and a first opposed loop disposed generally opposite to the first contractible loop, wherein reduction of the first opposed loop contracts the first contractible loop from the expanded state into the reduced state and secures the suture construct in the reduced state. The suture construct may also include a second reduction construct. Optionally, the suture system includes a first and a second pusher tube defining a first and a second lumen, respectively, wherein each pusher tubes are advanced over portions of opposed loops, respectively, and wherein distal portions of opposed loops extend beyond the pusher tubes, respectively.

Implant and anchor assembly

An implant assembly comprising an implant having a load bearing surface with a contour corresponding to a patient's articular surface, and a bone facing surface including a fixation element, an anchor configured to be secured to bone beneath said patient's articular surface, said anchor including a second fixation element, and wherein said first fixation element is configured to be secured to said second fixation element.

System and method for repairing articular surfaces

A joint replacement system for repairing an articular surface of a first bone of a joint includes an anchor portion and an implant portion. The anchor portion includes an anchor to be secured to the bone, and an anchor fixation head including a bone-facing surface (BFS) extending radially outward from the anchor and an implant facing surface (IFS) extending from a periphery of the BFS. The implant portion is formed from a material (e.g., CoCr) more dense than the material of the anchor portion (e.g., Ti) and includes a fixation cavity to receive at least a portion of the anchor fixation head (AFH), the fixation cavity includes an anchor facing surface (AFS) configured to form a frictional connection with the IFS, and a load bearing surface having a contour for articulating against a cooperating articulating surface of a second bone of the joint.

Multicomponent articular surface implant

A multicomponent implant system includes a multicomponent implant comprising a base plate and a load plate. The base plate includes a bone facing surface and a base plate interface surface. The load plate includes a load plate interface surface and a load bearing surface, the load bearing surface being substantially parallel to the load plate interface surface and having a contour substantially corresponding to a contour of a removed portion of the articular surface. Both the load plate interface surface and base plate interface surface have a contour substantially corresponding to the contour of the load bearing surface. The load plate is configured to be advanced in an arcuate direction to slidably couple the load plate to the base plate after the base plate has been secured within the first excision site by an anchor.

Humeral and glenoid articular surface implant systems and methods

One embodiment of the present disclosure provides a humeral implant. The humeral implant includes a tray including a body defining a bone facing recess and a liner recess, said bone facing recess including a ring surface and a convex surface, wherein the ring surface has a profile substantially corresponding to a profile of an outer ring of bone in an excision site of a patient; and wherein said convex surface has a profile substantially corresponding to a profile of a concave socket formed in the excision site. The humeral implant also includes a liner including a body defining a load bearing surface and a tray interface surface, said tray interface surface being configured to be at least partially received in said liner recess of said tray such that said implant is coupled to said tray.

Production of light olefins

The process for the production of light olefins from a feedstock comprising methanol, ethanol, dimethyl ether, diethyl ether or mixtures thereof comprising contacting said feedstock with a silicoaluminophosphate molecular sieve at effective process conditions to produce light olefins.

Production of light olefins

The process for the production of light olefins from a feedstock comprising at least an aliphatic hetero compound comprising contacting said feedstock in the presence of an aromatic diluent with a silicoaluminophosphate molecular sieve at effective process conditions to produce light olefins.

Adesivo de fusÆo a quente embalagem artigo para embalagem e processo de polimeriza-Æo

Process using polypropylene or poly (ethylene co propylene) succinimide as antifouling additive in petroleum refinery processes

The present invention provides a method for reducing fouling, including particulate-induced fouling, in a hydrocarbon refining process including the steps of providing a crude hydrocarbon for a refining process; adding at least one polyalkyl succinic anhydride derivative additive disclosed herein. The additive can be complexed with a boronating agent, such as boric acid, to yield a boron-containing polyalkyl succinic anhydride derivative.

Polyalkyl succinic anhydride derivatives as additives for fouling mitigation in petroleum refinery processes

The present invention provides a method for reducing fouling, including particulate-induced fouling, in a hydrocarbon refining process including the steps of providing a crude hydrocarbon for a refining process; adding at least one polyalkyl succinic anhydride derivative additive disclosed herein. The additive can be complexed with a boronating agent, such as boric acid, to yield a boron-containing polyalkyl succinic anhydride derivative.

Addition of high molecular weight naphthenic tetra-acids to crude oils to reduce whole crude oil fouling

High molecular weight naphthenic tetra-acids are added to a base crude oil to prevent and/or reduce fouling of crude oil refinery equipment. The method includes adding an effective amount of a high molecular weight naphthenic tetra-acid to the base crude oil to form a crude oil mixture and feeding the crude oil mixture to a crude oil refinery component. Particularly, the high molecular weight naphthenic tetra-acids include ARN acids.

System for assigning discrete time periods for dye applicators in a textile dyeing apparatus

A control system for a textile dying apparatus processes and distributes digitally encoded pattern information. A substrate is moved on a path along which the surface of the substrate comes into operative range of a plurality of arrays arranged along the path of the substrate. Each of the arrays has a plurality of individual dye applicators capable of selectively projecting a stream of dye onto a predetermined portion of the substrate corresponding to a pattern element in a pattern composed of a pattern element matrix with a plurality of pattern elements in each of a plurality of pattern rows. Each pattern element is associated with a visually distinct pattern area. The dye applicators project dye for a time period determined by the pattern information. The method first determines a set of initial values. From the initial values it generates a firing command matrix having, for each dye applicator in each array, a firing command sequence corresponding to the pattern element to which that dye applicator may apply dye in each pattern row. Finally, the method allocates, for simultaneous transmission to each dye applicator in each array, the firing command sequence in the firing command matrix corresponding to the pattern element in the pattern row to be applied to the predetermined portion of the substrate that is passing within operative range of the dye applicator at the time of transmission. <IMAGE>

Net shape moldable thermally conductive materials

A method of making a heat exchanger with a net shape moldable highly thermally conductive polymer composite includes mixing a polymer and a thermally conductive filler material and molding the polymer composite into heat exchanger components. The heat exchanger can be tailored to varying heating and cooling needs with moldable geometries.

Acetic acid from ethane, ethylene and oxygen

A process for the higher selective production of acetic acid by the catalytic oxidation with oxygen of ethane, or ethylene, or mixtures thereof, in contact with a mixed catalyst composition containing (A) a calcined mixed oxides catalyst of the formula: Mo.sub.x V.sub.y Z.sub.z wherein Z represents nothing or a metal from a group of metals as hereinafter defined and (B) is an ethylene hydration catalyst and/or an ethylene oxidation catalyst.

Production of neopentane

Disclosed herein are processes for producing neopentane. The processes generally relate to demethylating isooctane to produce neopentane. The isooctane may be provided by the alkylation of isobutane with butylenes.

Direct-patterned optical waveguides on amorphous silicon films

An optical waveguide structure is formed by embedding a core material within a medium of lower refractive index, i.e. the cladding. The optical index of refraction of amorphous silicon (a-Si) and polycrystalline silicon (p-Si), in the wavelength range between about 1.2 and about 1.6 micrometers, differ by up to about 20%, with the amorphous phase having the larger index. Spatially selective laser crystallization of amorphous silicon provides a mechanism for controlling the spatial variation of the refractive index and for surrounding the amorphous regions with crystalline material. In cases where an amorphous silicon film is interposed between layers of low refractive index, for example, a structure comprised of a SiO 2 substrate, a Si film and an SiO 2 film, the formation of guided wave structures is particularly simple.