SHOCK ABSORBING STRUCTURE AND THE AUTOMOBILE FRONT SHIELD COMPRISING

ARRANGEMENT FOR MOUNTING A BUMPER BAR MOTOR VEHICLE BY MEANS OF TRANSFER

AGENCEMEMENT Of a TRAP DOOR HAS FUEL OF MOTOR VEHICLE.

ASSEMBLY OF SENSORS Of ASSISTANCE TO the PARKING WITHOUT INTERFERENCE

SHIELD BUMPER FOR A MOTOR VEHICLE COMPRISING A DESTRUCTIBLE POINT DEFIXATION

Functionalized Particles and Use Thereof

A method of making a powder coating composition includes obtaining functionalized particles by reacting inorganic particles with alkoxysilanes having the general structural formula (I) RSi(OR), silane oligomers having the general structural formula (II) (R)(OR)Si-O-[-Si(R)(OR)-O-]-Si(R)(OR)or mixtures thereof. 2. The powder coating composition as claimed in claim 1 , which comprises functionalized particles obtainable by a method which comprises subjecting the reaction mixture obtained after the reaction to drying.3. The powder coating composition as claimed in claim 1 , wherein titanium dioxide particles or barium sulfate particles are used as inorganic particles.4. The powder coating composition as claimed in claim 1 , comprising:a. 20% to 80% by weight of binder,b. 5% to 60% by weight of inorganic pigment or mineral filler,c. 5% to 60% by weight of functionalized inorganic particles,d. 0.1% to 10.0% by weight of additive, selected from flow, leveling, and deaerating additives or mixtures thereof, with all of the ingredients together making 100% by weight.5. The powder coating composition according to claim 4 , where the functionalized pigment and/or the filler is present in an amount of 10% to 50% by weight claim 4 , preferably 30% to 40% by weight.6. (canceled)7. An article powder coated with the coating composition according to .89-. (canceled)11. A method as claimed in claim 10 , wherein Ris a nonhydrolyzable claim 10 , aliphatic claim 10 , straight-chain or branched-chain hydrocarbon radical having 1 to 10 carbon atoms.12. A method as claimed in claim 10 , wherein Ris a nonhydrolyzable claim 10 , aliphatic claim 10 , straight-chain or branched-chain hydrocarbon radical having at least one terminal claim 10 , functional group which is able to enter into an addition reaction or condensation reaction.13. A method as claimed in claim 10 , wherein Ris a nonhydrolyzable claim 10 , aliphatic claim 10 , straight-chain or branched-chain hydrocarbon radical having at ...

SURFACE TREATMENT OF PARTICLES AND THEIR USE

Surface treatment of titanium dioxide, barium sulfate, zinc sulfide, and/or lithopone particles, and mixtures of said particles with specific alkoxylated siloxanes for the improvement of dispersion in plastics. 2. The particle as claimed in claim 1 , wherein{'sup': 1', '3, 'sub': 2', 'p', 'x', 'y', 'z, 'Ridentically or differently is —(CH)—O-EO—PO—BO—R,'}{'sup': '1', 'with the proviso that in Rthe total number of carbon atoms and oxygen atoms is at least 70,'}EO is oxyethylene,PO is oxypropylene,BO is oxybutylene,x is from 0 to 20,y is from 5 to 100,z is from 0 to 20,p is from 2 to 4.3. The particle as claimed in claim 1 , wherein a numeric ratio of a to b is from 8:1 to 18:1.4. The particle as claimed in claim 2 , index wherein x is between 0.05 and 1.2 times a sum of y and z.5. The particle as claimed in claim 2 , whereinR is methyl,A is from 80 to 95,B is from 5 to 8,{'sup': '3', 'Ris hydrogen,'}x is from 3 to 5,y is from 10 to 25,z is 0.6. The particle as claimed in claim 1 , which is a surface-treated is TiOparticle.7. The particle as claimed in claim 1 , which has a dust value of at most 80 mg per 100 g of surface-treated particles.9. A process for producing a polymer composition claim 1 , comprising mixing the particle of with a polymer.10. The process as claimed in claim 9 , wherein the polymer composition is processed to give a plastic molding or a plastic film.11. A composition claim 1 , comprising a polymer claim 1 , which comprises a particle as claimed in .12. The composition as claimed in claim 11 , wherein the polymer is a thermoset or thermoplastic.13. The composition as claimed in claim 11 , which is a masterbatch claim 11 , a plastic molding claim 11 , or a plastic film.14. The particle of claim 2 , which is a surface-treated TiOparticle.15. The particle of claim 1 , whereinZ is a branched alkylene moiety or an unbranched alkylene moiety comprising 3 carbon atoms,m is 3,n is 1 or 2,o is 0,a is from 30 to 170, andb is from 2 to 30,where 0.05 to 1% ...

Compositions for inhibiting ubiquitin specific protease 1

This disclosure relates to modulating ubiquitin specific protease 1 (USP1) and provides novel chemical compounds useful as inhibitors of USP1, as well as various uses of these compounds. USP1 inhibiting compounds are useful in the treatment of diseases and disorders associated with USP1, such as cancer.

Method for treating the surface of particles, the thus obtained particles and use thereof

A method for producing surface-treated particles includes surface treatment of titanium dioxide, barium sulfate, zinc sulfide or lithopone particles, and to mixtures of the particles with alkoxylated siloxanes and phthalate-free plasticizers for improving dispersion in plastics. 2. The particles according to claim 1 , wherein in formula (I):{'sup': '1', 'Ris a polyether group of formula (II), in which'}Z is equal to an unbranched alkylene group having 2 to 4 carbon atoms,o is 0,x is 0 to 20,y is 5 to 100,z is 0 to 20.3. The particles according to claim 1 , wherein the numerical ratio of index a to index b in formula (I) is equal to 8 to 18.4. The particles according to claim 2 , wherein the index x is between 0.05 and 1.2 times the sum of indices y+z.5. The particles according to claim 2 , wherein:R is equal to methyl,{'sup': '3', 'Ris hydrogen,'}a is 80 to 95,b is 5 to 8,x is 3 to 5,y is 10 to 25,z is 0.6. The particles according to claim 1 , wherein the particles are TiO.7. The particles according to claim 1 , having a dust value of at most 30 mg per 100 g of surface-treated particles.8. The particles according to claim 1 , wherein the at least one phthalate-free plasticiser is selected from the group consisting of{'sub': 3', '2, 'esters of aliphatic hydrocarbons having 6 to 21 carbon atoms with at least one acid group selected from the group consisting of a carboxyl group, sulfonyl group —SOH, and sulfinyl group —SOH, with a monovalent or polyvalent aliphatic alcohol having 6 to 20 carbon atoms or a monovalent or bivalent aromatic alcohol, and'}esters of aromatic 1,4-(para)dicarboxylic acids or aromatic tricarboxylic acids with a monovalent or polyvalent aliphatic alcohol having 6 to 20 carbon atoms.11. The method for producing surface-treated particles from TiO claim 9 , BaSO claim 9 , ZnS or lithopone according to claim 9 , wherein the at least one phthalate-free plasticiser is selected from the group consisting of{'sub': 3', '2, 'esters of aliphatic ...

PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: 141-. (canceled)43. The compound of claim 42 , wherein Xis CR.44. The compound of claim 42 , wherein Ris selected from the group consisting of H claim 42 , (C-C) alkyl claim 42 , (C-C) alkenyl claim 42 , (C-C) alkynyl claim 42 , (C-C) haloalkyl claim 42 , (C-C) hydroxyalkyl claim 42 , or heterocycloalkyl claim 42 , wherein the alkyl claim 42 , alkenyl claim 42 , alkynyl claim 42 , and heterocycloalkyl are optionally substituted with one or more substituents selected from halogen —OR claim 42 , —C(O)R claim 42 , —NRR claim 42 , —NRC(O)R claim 42 , —C(O)NRR claim 42 , —NRC(O)NRR claim 42 , —NRS(O)R claim 42 , —S(O)NRR claim 42 , —NRS(O)NRR claim 42 , —S(O)R claim 42 , —P(O)RR claim 42 , and —Si((C-C) alkyl).45. The compound of claim 42 , where Ris H claim 42 , methyl claim 42 , —CHCHOH claim 42 , —CHCHNH claim 42 , —CH(CH)C(O)OH claim 42 , or piperidinyl optionally substituted with —C(O)R.46. The compound of claim 42 , where Ris H or methyl.47. The compound of claim 42 , wherein Ris (C-C) alkyl claim 42 , (C-C) alkoxy claim 42 , (C-C) haloalkyl claim 42 , (C-C) haloalkoxy claim 42 , (C-C) cycloalkyl claim 42 , halogen claim 42 , —NH claim 42 , or —C(O)(C-C) alkyl claim 42 , wherein the alkyl is optionally substituted with one to three substituents (C-C) alkoxy.48. The compound of claim 42 , wherein Ris heterocycloalkyl.49. The compound of claim 49 , wherein Ris pyrrolidinyl claim 49 , piperazinyl claim 49 , or piperidinyl.50. The compound of claim 42 , wherein Rand Xtogether with the atoms to which they are attached form a (C-C) aryl ring optionally substituted with one or more R.51. The compound of claim 42 , wherein Rand Xon adjacent atoms together with the atoms to which they are attached form a heteroaryl ring optionally substituted with one or more R.52. The compound of claim 42 , wherein Rand Xtogether with the ...

SIDE AIRBAG MODULE AND VEHICLE SEAT

A side airbag module for being attached to a seat frame () is described. Said airbag module has an inflator and at least one mounting stud () extending from said inflator. An airbag defining a gas space and being in fluid communication to said inflator is provided and is at least partially rolled and/or folded to an airbag package (). The airbag package () is held by a wrapper () encircling at least a part of the airbag package (). In order to simplify the mounting process of upholstery, at least one additional flexible flap () extends from the wrapper () and said additional flexible flap () has or carries at least one connection means for connecting the flexible flap to the frame () of a vehicle seat. 1. A side airbag module comprising:an inflator unit having an inflator and at least one mounting stud extending from said inflator,an airbag defining a gas space being in fluid communication to said inflator, said airbag being at least partially rolled and/or folded to an airbag package,a wrapper encircling at least a part of the airbag package, andat least one additional flexible flap extending from the wrapper, said additional flexible flap having or carrying at least one connection means for connecting the flexible flap to the frame of a vehicle seat at least indirectly.2. The side airbag module of claim 1 , wherein the at least one connection means comprises a hole in the additional flexible flap.3. The side airbag module of claim 1 , wherein the at least one connection means comprises a hook attached to the additional flexible flap.4. The side airbag module of claim 1 , characterized in that the wrapper shows a breaking line in its front end area.5. The side airbag module of claim 4 , wherein the additional flexible flap does not extend over the breaking line of the wrapper.628. The side airbag module of claim 4 , wherein the additional flexible flap extends over the breaking line () of the wrapper and shows an additional breaking line basically in front of the ...

COATING COMPOSITIONS

TiO-free coating compositions and mineral blends for use in TiO-free coating compositions. 1. A coating composition comprising a mineral blend and no greater than about 1.0 wt. % TiO , based on the total weight of the coating composition , wherein the mineral blend comprises:ground calcium carbonate as a matting mineral, a whitening mineral, or both; andcalcined kaolin as an opacifying mineral, a whitening mineral, or both.2. The coating composition according to claim 1 , wherein the ground calcium carbonate has a dof at least about 2.0 μm.3. The coating composition according to claim 1 , wherein the calcined kaolin has a dof at least about 0.5 μm.4. The coating composition according to claim 1 , wherein the coating composition comprises at least about 5 wt. % ground calcium carbonate claim 1 , based on the total weight of the coating composition.5. The coating composition according to claim 1 , wherein the coating composition comprises at least about 10 wt. % calcined kaolin claim 1 , based on the total weight of the coating composition.6. The coating composition according to claim 1 , wherein the coating composition comprises at least about 35 wt. % of the mineral blend claim 1 , based on the total weight of the coating composition.7. The coating composition according to claim 1 , further comprising a PVC from about 60% to about 90%.8. The coating composition according to claim 1 , wherein the mineral blend comprises at least one further mineral from the following group: hydrous kaolin as an opacifying mineral claim 1 , precipitated calcium carbonate as an opacifying mineral and/or whitening mineral claim 1 , natural diatomaceous earth as a matting mineral and/or opacifying mineral claim 1 , flux calcined diatomaceous earth as a matting mineral and/or opacifying mineral claim 1 , talc as a matting mineral and/or opacifying mineral claim 1 , wollastonite as a matting mineral claim 1 , perlite as a matting mineral claim 1 , mica as a matting mineral claim 1 , quartz ...

PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: 241-. (canceled)42. The compound of claim 1 , wherein:{'sub': 1', '6, 'Xis CR;'}{'sub': '2', 'Xis N;'}{'sub': 3', '8, 'Xis CR; and'}{'sub': '4', 'Xis N.'}43. The compound of claim 42 , wherein Ris H claim 42 , (C-C) hydroxyalkyl claim 42 , heterocycloalkyl claim 42 , or (C-C) alkyl optionally substituted with one or two substituents selected from —COH claim 42 , —NH claim 42 , and —N((C-C) alkyl).4443. The compound of claim 42 , wherein Ris H or methyl.45. The compound of claim 44 , wherein Ris (C) aryl claim 44 , 5- or 6-membered heteroaryl claim 44 , (C-C) cycloalkyl claim 44 , or 5- or 6-membered heterocycloalkyl claim 44 , wherein the aryl claim 44 , heteroaryl claim 44 , cycloalkyl and heterocycloalkyl are substituted with one or more R.46. The compound of claim 45 , wherein Ris phenyl claim 45 , pyrazolyl claim 45 , pyridinyl claim 45 , pyridin-2-onyl claim 45 , pyrimidinyl claim 45 , cyclobutyl claim 45 , cyclohexyl claim 45 , piperidinyl claim 45 , piperidinonyl claim 45 , pyridinonyl claim 45 , or pyrrolinyl claim 45 , wherein each Ris substituted with one to three R.48. The compound of claim 47 , wherein Rand R are each independently H or (C-C) alkyl.49. The compound of claim 48 , wherein Ris H or Calkyl and Ris H or methyl.50. The compound of claim 48 , wherein Ris (C-C) alkyl claim 48 , (C-C) alkoxy claim 48 , (C-C) haloalkyl claim 48 , (C-C) haloalkoxy claim 48 , (C-C) cycloalkyl claim 48 , halogen claim 48 , —NH claim 48 , or —C(O)(C-C) alkyl claim 48 , wherein the alkyl is optionally substituted with one to three substituents (C-C) alkoxy.51. The compound of claim 48 , wherein Ris (C-C) alkyl claim 48 , halogen claim 48 , (C-C) haloalkyl claim 48 , (C-C) haloalkoxy claim 48 , or (C-C) alkoxy optionally substituted with (C-C) alkoxy.52. The compound of claim 50 , wherein Ris H.53. The compound of claim ...

PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: 2. The compound of claim 1 , wherein:{'sub': 1', '6, 'Xis CRor N;'}{'sub': 2', '7, 'Xis CRor N;'}{'sub': 3', '8, 'Xis CRor N;'}{'sub': 4', '9, 'Xis CRor N;'}{'sub': 1', '1', '6', '2', '6', '2', '6', '1', '6', '2', '6', '20', '20', '2', '20', '18', '19', '2', '21', '20', '21', '20', '21', '22', '20', 'r', '21', 'r', '20', '21', '20', 'r', '21', '22', 'r', '20', '20', '21', '1', '4', '3, 'Ris H, (C-C) alkyl, (C-C) alkenyl, (C-C) alkynyl, (C-C) haloalkyl, (C-C) hydroxyalkyl, or heterocycloalkyl, wherein the alkyl, alkenyl, alkynyl, and heterocycloalkyl are optionally substituted with one or more substituents selected from halogen, —OR, —C(O)R, —COR, —NRR, —NROC(O)R, —C(O)NRR, —NRC(O)NRR, —NRS(O)R, —S(O)NRR, —NRS(O)NRR, —S(O)R, —P(O)RR, and —Si((C-C) alkyl)'}{'sub': 2', '6', '14', '3', '8', '10, 'Ris (C-C) aryl, heteroaryl, (C-C) cycloalkyl, or heterocycloalkyl, wherein the aryl, heteroaryl, cycloalkyl, and heterocycloalkyl are substituted with one or more R;'}{'sub': 3', '1', '6', '1', '6', '1', '6', '1', '6', '2, 'Ris H, (C-C) alkyl, (C-C) haloalkyl, (C-C) hydroxyalkyl, (C-C) aminoalkyl, heterocycloalkyl, —C(O)OH, —C(O)NH, or CN;'}{'sub': 3′', '1', '6', '1', '6', '1', '6', '1', '6', '2, 'R is H, (C-C) alkyl, (C-C) haloalkyl, (C-C) hydroxyalkyl, (C-C) aminoalkyl, heterocycloalkyl, —C(O)OH, —C(O)NH, or CN; or'}{'sub': 3', '3′', '3', '7', '3', '3′, 'Rand R together with the carbon atom to which they are attached may form a (C-C) cycloalkyl ring; Rand R together with the carbon atom to which they are attached form a heterocycloalkyl ring;'}{'sub': 4', '1', '6', '2', '6', '2', '6', '1', '6', '1', '6', '1', '6', '3', '8', '2', '1', '4', '1', '4', '1', '4', '2', '1', '6', '1', '6', '3', '8', '2', '1', '4', '1', '4', '2, 'Ris (C-C) alkyl, (C-C) alkenyl, (C-C) alkynyl, (C-C) alkoxy, (C-C) haloalkyl, (C-C) haloalkoxy, (C-C) ...

3,6-diamino-pyridazin-3-yl derivatives, pharmaceutical compositions containing them and their uses as pro-apoptotic agents

Compounds of formula (I): wherein Het 1 , Het 2 , R 1 , R 2 and R 3 are as defined in the description.

METHODS FOR CHARACTERIZING LOSS OF ANTIGEN PRESENTATION

This invention relates to methods for screening for a genotype for loss of antigen presentation via MHC class I in a subject and/or respectively detecting a subject's increased risk of resistance against immunotherapy such as against vaccination. 1. A method for screening for a genotype for loss of antigen presentation via MHC class I , comprising: obtaining a sample containing nucleic acid from a subject , and identifying a chromosomal deletion and inversion event in a chromosome 15 , wherein the deletion and inversion event results in the loss of the beta-2-microglobulin (B2M) locus , and wherein the presence of the chromosomal deletion and inversion event indicates that the subject possesses a genotype for loss of antigen presentation via MHC class I.2. The method of claim 1 , wherein identifying a chromosomal deletion and inversion event in a chromosome 15 comprises detecting the presence or absence of a nucleic acid sequence comprising a sequence selected from the group consisting of:a sequence identifying a chromosomal deletion and inversion event in a chromosome 15, wherein the deletion and inversion event results in the loss of the beta-2-microglobulin (B2M) locus, and comprising the sequence set forth in SEQ ID NO: 9, the sequence set forth in SEQ ID NO: 9 surrounding the end point of the deletion, which is the start point of the inverted region,(ii) the sequence set forth in SEQ ID NO: 17 or a portion thereof of at least 40 nucleotides comprising the sequence set forth in SEQ ID NO: 10,(iii) the sequence set forth in SEQ ID NO: 21 or a portion thereof of at least 40 nucleotides comprising the sequence set forth in SEQ ID NO: 10,(iv) a sequence complementary to the sequences set forth in any one of (i) to (iii), and(v) a sequence which is at least 90% identical to the sequences set forth in any one of (i) to (iv), wherein detection of the nucleic acid sequence indicates the presence of a chromosomal deletion and inversion event in a chromosome 15 that is ...

METHOD FOR SETTING UP AND/OR CALIBRATING A ROBOT

A method for setting up and/or calibrating a robot positioned in a work environment at an operation site, wherein a predetermined routine is carried out for the purposes of setting up and/or calibration. The method includes the steps of generating the routine for the robot at a simulation site distant from the operation site; after completing the generation of the routine, transmitting the routine to a control unit of the robot at the operation site; calling up the routine and remotely executing the routine at the operation site via a control center located remotely from the operation site; and, after the start of the generated routine, allowing the generated routine to automatically process without intervention by an operator at the operation site. 1. A method for at least one of setting up and calibrating a robot positioned in a work environment at an operation site , wherein a predetermined routine is processed for at least one of the purposes of setting up and calibration , the method comprising the steps of:generating the routine for the robot at a simulation site distant from the site of operation;after completing the generation of the routine, transmitting the routine to a control unit of the robot at the operation site;calling up the routine at the operation site and remotely executing the routine at the operation site via a control center located remotely from the operation site; and,after the start of the generated routine, allowing the generated routine to automatically process without intervention by an operator at the operation site.2. The method of claim 1 , comprising the further steps of:first virtually executing setting up and/or calibrating the robot at the simulation site utilizing the generated routine; and,only after successfully completing the virtual setting up, transmitting the routine to the control unit of the robot at the operation site.3. The method of claim 1 , wherein the routine is generated offline at the simulation site without a ...

PRODRUGS OF HIV REVERSE TRANSCRIPTASE INHIBITORS

Compounds of Formula I are described: wherein Rand Rare defined herein. The compounds of Formula I are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV, and the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. 4. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Ris methyl substituted with 1 claim 1 , 2 or 3 of —F; or ethyl substituted with 1 claim 1 , 2 or 3 of —F.5. The compound of claim 4 , or a pharmaceutically acceptable salt thereof claim 4 , wherein Ris —CHF claim 4 , —CF claim 4 , or —CFCH.6. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Ris —F; —Cl; methyl substituted with 1 claim 1 , 2 or 3 of —F; ethyl substituted with 1 claim 1 , 2 or 3 of —F; or phenyl substituted with —F.7. The compound of claim 6 , or a pharmaceutically acceptable salt thereof claim 6 , wherein Ris —Cl claim 6 , —CHF claim 6 , —CF claim 6 , —CFCH claim 6 , or phenyl substituted with —F.10. A pharmaceutical composition comprising an effective amount of a compound of or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.11. A pharmaceutical composition comprising an effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , and a pharmaceutically acceptable carrier and further comprising an effective amount of an anti-HIV agent selected from an anti-HIV antiviral agent claim 1 , an immunomodulator claim 1 , or anti-infective agent.12. The pharmaceutical composition of claim 11 , wherein the anti-HIV antiviral agent is an HIV protease inhibitor claim 11 , HIV reverse transcriptase inhibitor claim 11 , HIV integrase inhibitor claim 11 , HIV fusion inhibitor claim 11 , HIV entry inhibitor ...

AN AIRBAG UNIT FOR A MOTOR VEHICLE SAFETY DEVICE

An airbag unit for a motor vehicle safety device includes an inflatable airbag and a cover. The inflatable airbag is formed of flexible material and provided in a rolled and/or folded package. The cover extends around at least part of the package. The cover includes a first cover portion and a second cover portion. The first cover portion is located on a first side of the package, and at least a region of the second cover portion being located on an opposite second side of the package. The second cover portion is substantially flexible and is connected to or formed integrally with the first cover portion, and the first cover portion has a predetermined stable shape and is relatively rigid in comparison to the second cover portion. 1. An airbag unit for a motor vehicle safety device , the unit comprising:an inflatable airbag formed of flexible material and provided in a rolled and/or folded package; anda cover extending around at least part of the package, the cover including a first cover portion and a second cover portion, the first cover portion being located on a first side of the package, and at least a region of the second cover portion located on an opposite second side of the package,wherein the second cover portion is substantially flexible and is connected to or formed integrally with the first cover portion, and the first cover portion has a predetermined stable shape and is relatively rigid in comparison to the second cover portion.2. The airbag unit according to claim 1 , wherein the first cover portion is formed from ductile fabric material comprising a plurality of polymeric fibres claim 1 , at least some of the fibres being fused together to impart the predetermined stable shape to the first cover portion.3. The airbag unit according to claim 2 , wherein the plurality of polymeric fibres includes a plurality of core-sheath bi-component fibres claim 2 , sheaths of the bicomponent fibres fused together to impart the predetermined stable shape to the ...

Method for collecting data, sensor and supply network

A method for collecting data of a consumption, a physical or physico-chemical parameter and/or an operating state in a supply network for consumables. A measuring element of a local sensor provides elementary measuring units, which correspond to at least one physical or physico-chemical variable or at least one physical or physico-chemical parameter, as raw measurement data. In order to determine the measurement resolution of the sensor, the conditions for generating time stamps are determined in advance using a correlation model, time stamps of successive raw measurement data are generated in the sensor on the basis of the correlation model, and the time stamps are transmitted via a wired connection and/or via a radio path. The raw measurement data are reconstructed and evaluated based on the time stamps with the correlation model. The conditions for generating time stamps can be changed dynamically within the framework of the correlation model.

Method for Separating N,N,N'-Trimethylbisaminoethylether and/or N,N-Dimethylbisaminoethylether from a Mixture

The present invention relates to a method for separating N,N,N′-trimethylbisaminoethylether and/or N,N-dimethylbisaminoethylether, from a mixture A comprising N,N,N′-trimethylbisaminoethylether, and N,N-dimethylbisaminoethylether, wherein said method comprises the steps of: (a) contacting said mixture A with an acylating agent, to form a mixture B comprising the amides of N,N,N′-trimethylbisaminoethylether and of N,N-dimethylbisaminoethylether, respectively; and (b1) separating the amide of N,N,N′-trimethylbisaminoethylether from mixture B; and (c1) recovering N,N,N′-trimethylbisaminoethylether from its amide by means of a transamidation reaction; and/or (b2) separating the amide of N,N-dimethylbisaminoethylether from mixture B; and (c2) recovering N,N-dimethylbisaminoethylether from its amide by means of a transamidation reaction.

Cover Element For An Airbag Module, And Airbag Module Having Such A Cover Element

A cover element () for an airbag unit having a stationary section, a first flap (), and a second flap (), wherein the first flap () is connected to the stationary section by at least one first hinge (), and the second flap () by at least one second hinge (). The two flaps () are connected to each other by a tear connection (). The first flap () has an outer area () and an emblem area (), which protrude at least partially from the outer area () and extend into the second flap (). In order that the emblem area () is not in the way of the expanding airbag even if the emblem area () is relatively large, the emblem area () is connected to the outer area () of the first flap () by a third hinge (), so that the emblem area () can swing against the outer area () when the first flap () is open. 1. A cover element for an airbag unit comprising a stationary section , a first flap and a second flap , wherein the first flap is connected to the stationary section by at least one first hinge , and the second flap is connected to the stationary section by at least one second ,wherein, in an initial state in which the airbag unit is undeployed, the first and the second flaps are connected to each other by a first tear-away connection,wherein the first flap has a first outer area and an emblem area, which protrudes at least partially from the outer area and extends into the second flap,the emblem area is connected to the outer area, of the first flap by a third hinge, so that the emblem area can swing against the outer area when the first flap is open upon a deployment of the airbag unit.2. The cover element according to claim 1 , further comprising in the initial state of the airbag unit the emblem area is still connected to the outer area of the first flap by a second tear-away connection.3. The cover element according to claim 2 , further comprising the first tear-away connection also connects the emblem area to the second flap.4. The cover element according to further comprising ...

METHOD FOR DETERMINING A STRUCTURAL STATE OF A MECHANICALLY LOADED UNIT

A structural state of at least one component of a mechanically loaded target unit, in particular a target unit of a rail vehicle, can be determined by introducing, in an actual excitation step of an evaluation cycle, a defined actual mechanical input signal into the target unit, capturing, in an actual capturing step of the evaluation cycle, an actual mechanical response signal of the target unit to the mechanical input signal, and comparing, in an actual evaluation step of the evaluation cycle, the actual mechanical response signal to a previously recorded baseline signal to establish an actual differential feature and using the actual differential feature to determine the structural state. The baseline signal is representative of a previous mechanical response signal of the target unit to a previous mechanical input signal. 1. A method for determining a structural state of at least one component of a mechanically loaded target unit , in particular a target unit of a rail vehicle , said method comprising ,in an actual excitation step of an evaluation cycle, introducing a defined actual mechanical input signal into said target unit,in an actual capturing step of said evaluation cycle, capturing an actual mechanical response signal of said target unit to said mechanical input signal, and,in an actual evaluation step of said evaluation cycle, comparing said actual mechanical response signal to a previously recorded baseline signal to establish an actual differential feature and using said actual differential feature to determine said structural state;wherein said baseline signal being representative of a previous mechanical response signal of said target unit to a previous mechanical input signal, said previous mechanical input signal having a defined relation to said actual mechanical input signal;wherein in an actual differential feature comparison step of said actual evaluation step, comparing said actual differential feature to at least one reference to determine ...

AMPHIPHILIC COPOLYMERS AS SURFACE MODIFIERS FOR PRODUCTION OF IMPROVED CALCIUM CARBONATE POWDERS

This disclosure describes a process for producing a surface-modified calcium carbonate, the process comprising contacting a calcium carbonate or precursor thereof with at least one amphiphilic copolymer comprising hydrophilic subunits and hydrophobic subunits, in which the hydrophilic subunits derive from at least one ethylenically-unsaturated compound comprising a carboxylic acid group or salt or derivative thereof; the hydrophobic subunits derive from at least one ethylenically-unsaturated compound comprising a hydrophobic group; and the amphiphilic copolymer has a hydrophilic-lipophilic balance ranging from about 1 to about 40. Surface-modified calcium carbonates obtained from the process are also described, as well as compositions containing the surface-modified calcium carbonates. 1. A process for producing a surface-modified calcium carbonate , the process comprising mixing a calcium carbonate or precursor thereof with at least one amphiphilic copolymer comprising hydrophilic subunits and hydrophobic subunits , wherein:the hydrophilic subunits derive from at least one ethylenically-unsaturated compound comprising a carboxylic acid group or salt or derivative thereof;the hydrophobic subunits derive from at least one ethylenically-unsaturated compound comprising a hydrophobic group; andthe amphiphilic copolymer has a hydrophilic-lipophilic balance value ranging from about 1 to about 40, wherein the amphiphilic copolymer is a crosslinked copolymer.2. The process of claim 1 , wherein:the hydrophilic subunits derive from maleic acid or maleic anhydride; andthe hydrophobic subunits derive from diisobutylene and/or wherein the calcium carbonate is a precipitated calcium carbonate.3. The process of claim 1 , wherein the hydrophilic subunits derive from at least one carboxyl group-containing vinyl monomer claim 1 , and/or wherein the hydrophilic subunits derive from at least one carboxyl group-containing monomer selected from the group consisting of a (meth)acrylic ...

PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: 141-. (canceled)43. A pharmaceutical composition comprising the compound of claim 42 , or a pharmaceutically acceptable salt thereof claim 42 , and a pharmaceutically acceptable carrier in a unit dosage form.45. The composition of claim 44 , wherein the first base is KCO.46. The composition of claim 44 , wherein the palladium catalyst is Pd(dppf)Cl.CHCl.49. The composition of claim 48 , wherein the metal is iron powder.51. The composition of claim 50 , wherein the second base is N claim 50 ,N-diisopropylethylamine (DIEA). This application claims the benefit of and priority to U.S. provisional application No. 62/258,162, filed Nov. 20, 2015, the entire contents of which are incorporated herein by reference in its entirety.The present application is directed to inhibitors of ubiquitin-specific protease 1 (USP1) useful in the treatment of diseases or disorders associated with USP1 enzymes. Specifically, the application is concerned with compounds and compositions thereof, which inhibit USP1, methods of treating diseases or disorders associated with USP1, and methods of synthesis of these compounds.Ubiquitination is a reversible process which involves a family of deubiquitinating enzymes (DUBs) that regulate a variety of cellular processes by deconjugating ubiquitin from the substrate. DUBs are encoded by approximately 100 human genes and are classified into six families, with the largest family being the ubiquitin-specific proteases (USPs) that has more than 50 members. DUBs and their substrate proteins are often deregulated in cancers, supporting the hypothesis that targeting specific DUB family members may result in antitumor activity through enhancing the ubiquitination and subsequent degradation of oncogenic substrates and the activity of other key proteins involved in tumor growth, survival, differentiation and ...

Agent and process for colouring keratinic fibres

Colorant for keratin fibers, which is not mixed with an oxidant before use, is free from manganese salts and consists of a combination suitable for coloring keratin fibers in the presence of atmospheric oxygen in a suitable cosmetic medium. The combination comprises: (a) 4,5-diaminopyrazole derivative(s); and (b) compound(s) selected from 5-amino-2-methylphenol(s) (II) and/or m-phenylene diamine derivative(s) or their physiologically-compatible salts. Colorant for keratin fibers, which is not mixed with an oxidant before use, is free from manganese (Mn) salts and consists of a combination suitable for coloring keratin fibers in the presence of atmospheric oxygen in a suitable cosmetic medium. The combination comprises: (a) 4,5-diaminopyrazole derivative(s) (I) and (b) compound(s) selected from 5-amino-2-methylphenol(s) (II) and/or m-phenylene diamine derivative(s) (III) of the given formulae or their physiologically-compatible salts: R = hydrogen (H), a linear or branched 1-6 carbon (C) alkyl, 1-6 C monohydroxyalkyl, 2-6 C polyhydroxyalkyl, 1-5 C monoaminoalkyl or 2-6 C polyaminoalkyl group or a benzyl group, optionally mono-substituted by halogen or linear or branched 1-6 C alkyl or 1-6 C alkoxy; R1, R2, R3 = H or linear or branched 1-4 C alkyl, 2-4 C monohydroxyalkyl or 3-4 C polyhydroxyalkyl; R4, R5 = H, a linear or branched 1-6 C alkyl, 1-4 C alkoxy, 2-4 C monohydroxyalkoxy, 3-4 C polyhydroxyalkoxy, 2-4 C monohydroxyalkyl or 3-4 C polyhydroxyalkyl group or 2,4-diaminophenoxy-(1-4 C)-alkoxy An Independent claim is also included for a method for coloring hair by applying the colorant to the hair, without premixing with an oxidant and leaving for 5-45 minutes at 15-50 degrees C, then rinsing the hair with water, optionally washing with shampoo and drying.

Functionalized particles and their use

Die vorliegende Erfindung betrifft funktionalisierte Partikel, Verfahren zur Herstellung solcher funktionalisierten Partikel, sowie die Verwendung der funktionalisierten Partikel zur Herstellung von Beschichtungsmitteln und deren Verwendung zum Beschichten von Gegenständen. The present invention relates to functionalized particles, processes for producing such functionalized particles, and the use of the functionalized particles for producing coating compositions and their use for coating objects.

Almacenamiento y transporte de un catalizador para la producción de polímeros de olefina

Tambor (1) de presión para llenar, almacenar, transportar y descargar un catalizador (3) para la producción de polímeros de olefina, el tambor (1) de presión comprende un cuerpo (7) cilíndrico con un primer extremo (9) y un segundo extremo (11); una primera cabeza 5 (13) torisférica; una segunda cabeza (15) torisférica; un primer elemento (19) de acoplamiento que se adapta para permitir un flujo desde y hacia el tambor (1) de presión; un segundo elemento (21) de acoplamiento que se adapta para permitir un flujo de un gas (5) inerte en el tambor (1) de presión; un tercer elemento (23) de acoplamiento que se adapta para permitir un flujo del catalizador (3) en el tambor (1) de presión; un cuarto elemento (25) de acoplamiento que se adapta para permitir una salida del catalizador (3) desde el tambor (1) de presión; en el que el primer elemento (19) de acoplamiento, el segundo elemento (21) de acoplamiento, el tercer elemento (23) de acoplamiento y el cuarto elemento (25) de acoplamiento se integran en la primera cabeza (13) torisférica; un elemento (27) de medición de presión proporcionado en el primer elemento (19) de acoplamiento; en el que la primera cabeza (13) torisférica se dispone en el primer extremo (9) del cuerpo (7) cilíndrico y la segunda cabeza (15) torisférica se dispone en el segundo extremo (11) del cuerpo (7) cilíndrico; en el que la primera cabeza (13) torisférica y la segunda cabeza (15) torisférica se conectan al cuerpo (7) cilíndrico mediante soldadura (17) de penetración total en tal forma que el tambor (1) de presión se adapta para soportar presiones entre -0.5 y 9 bar g, y en el que el cuerpo (7) cilíndrico, la primera cabeza (13) torisférica y la segunda cabeza (15) torisférica se elaboran de acero inoxidable, y comprenden un grosor de pared de 1.5 a 3 mm.

Multicomponent composition

The instant disclosure generally relates to a multicomponent composition for coating mammalian or synthetic keratin material and textiles, the composition comprising a first and second components and a third component. The first and second components comprise first and second compounds respectively. Any one or more of the first, second and third components may also comprise pigment microparticles. The first, second and third compounds meld together on keratin material and textiles and especially on hair to form a coating that can be formulated to provide temporary coverage or provide permanent coverage. The multicomponent composition formed and set in situ as a solid linked coating ranges from ready removability to substantially permanent lastingness.

Zinc powder or zinc alloy powder for alkaline batteries

Zinc powder or zinc alloyed powder is used as an electrode and has a grain size distribution, in which 75-95 weight percent of particles have a diameter of between 40 and 140 microns. Settled apparent density lies in a range of between 2.9 and 4.5 g/cm3. Metals are chosen as alloyed elements from a group including indium, bismuth, lead, aluminum, calcium, lithium, sodium, magnesium and mixtures. An Independent claim is also included for an alkali battery with zinc powder as an anode.

Zinc powder or zinc alloy powder with inhomogeneous bulk density for alkaline batteries

Zinc powder or zinc alloy powder has an inhomogeneous bulk density distribution depending on the particle size. The difference of the bulk density measured according to ASTM B212 at a grain size amount of less than 75 mum to the grain size amount of more than 150 mum is at least 0.5 g/cm3 and the average bulk density of the powder according to ASTM B212 is in the region of 1.8-4.0 g/cm3. An Independent claim is also included for mixtures of zinc powder or zinc alloy powder.

Zinc powder or zinc alloy powder for alkaline batteries

The invention is directed to a zinc powder or zinc alloy powder for alkaline batteries, which powder has a grain size distribution wherein 60 to 100 wt.-% of the particles, relative to the zinc powder or zinc alloy powder, have a diameter of from 40 to 140 µm. The invention is also directed to an alkaline battery.

3(5)-ureido-pyrazole derivatives, process for their preparation and their use as antitumor agents

3-ureido-pyrazole derivatives represented by formula (I): where R, R1 and R2 are as described herein, or pharmaceutically acceptable salts thereof; are useful, for example, for the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenerative diseases.

3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents

3-ureido-pyrazole derivatives represented by formula (I): where R, R 1 and R 2 are as described herein, or pharmnaceutically acceptable salts thereof; are useful, for example, for the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenerative diseases.

Plug with locking bar and seal for telecommunications equipment - has replaceable sealing tablet inset in locking bolt release button flush with plug cover, with broken seal indicating unauthorised access

The plug for telecommunications circuit junction box connections contains a locking bolt (1) which is displaced when the plug is inserted into the junction box. The bolt can only then be unlocked after a sealing plug engaged inside the bolt release button is broken. The sealing plug consists of a tablet which fits hollow depression in the push button. The tablet is held in place by flexible retaining hooks which lock against the inside surface of the button. The inside end of the seal rests against the nearby fixing post which holds the plug cover in place. When the seal is properly inserted it is flush with the top of the release button. The tablet of the sealing plug contains a rupture zone. The locking bolt is held against a compression spring and prevents accidental withdrawal of the plug from the junction box. The bolt can only be released by perforating the seal and leaving evidence of any unauthorised removal. The broken seal is easily replaced without the need for any special tools.

treatment of neurological disease with zilucoplan

TRATAMENTO DE DOENÇA NEUROLÓGICA COM ZILUCOPLAN. A presente invenção refere-se a métodos de tratamento de miastenia grave com zilucoplan (RA101495), incluindo miastenia grave generalizada. A presente descrição também reivindica dispositivos e kits para administração de zilucoplan e métodos de avaliação da eficácia do tratamento com inibidor do complemento. TREATMENT OF NEUROLOGICAL DISEASE WITH ZILUCOPLAN. The present invention relates to methods of treating myasthenia gravis with zilucoplan (RA101495), including generalized myasthenia gravis. THE this description also claims devices and kits for administration of zilucoplan and methods of evaluating the effectiveness of complement inhibitor treatment.

Clay block and process for its manufacture

Catalyst for PIR/PUR foam production

The present disclosure is related to a catalyst for PIR/PUR foam production comprising a compound having the general formula (I) wherein R

3(5)-ureido-pyrazole derivatives, process for their preparation and their use as antitumor agents

3-ureido-pyrazole derivatives represented by formula (I): where R, R1 and R2 are as described herein, or pharmaceutically acceptable salts thereof; are useful, for example, for the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenerative diseases.

?SURFACE TREATMENT OF PARTICLES AND ITS USE?

TRATAMENTO DE SUPERFÍCIE DE PARTÍCULAS E SUA UTILIZAÇÃO. Tratamento de superfície para partículas de dióxido de titânio, sulfato de bário, sulfureto de zinco e/ou litopone, e misturas das referidas partículas com específicos siloxanos alcoxilados, para melhorar a dispersão em plásticos. PARTICLE SURFACE TREATMENT AND ITS USE. Surface treatment for particles of titanium dioxide, barium sulphate, zinc sulphide and/or lithopone, and mixtures of said particles with specific alkoxylated siloxanes, to improve dispersion in plastics.

DERIVATIVES OF 3 (5) -AMINOPIRAZOL, PROCEDURE FOR ITS PREPARATION AND ITS USE AS ANTITUMOR AGENTS.

Uso de un compuesto representado por la fórmula (I): en el que R es un grupo cicloalquilo C3-C6, opcionalmente sustituido por un grupo alquilo C1-C6 lineal o ramificado o arilalquilo; R1 es un grupo alquilo C1-C6 lineal o ramificado, alquenilo C2-C4, cicloalquilo, cicloalquenilo, heterociclilo, arilo, arilalquilo, arilcarbonilo, ariloxialquilo o arilalquenilo, cada uno de los cuales opcionalmente puede estar sustituido adicionalmente; o una sal farmacéuticamente aceptable del mismo para la fabricación de un medicamento para tratar trastornos de proliferación celular asociados a una actividad celular dependiente de quinasas alterada en un mamífero que lo necesite. Use of a compound represented by the formula (I): wherein R is a C3-C6 cycloalkyl group, optionally substituted by a linear or branched C1-C6 alkyl or arylalkyl group; R1 is a linear or branched C1-C6 alkyl, C2-C4 alkenyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, arylalkyl, arylcarbonyl, aryloxyalkyl or arylalkyl group, each of which may optionally be further substituted; or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for treating cell proliferation disorders associated with an altered kinase-dependent cellular activity in a mammal in need thereof.

Zinc powder or zinc alloy powder with inhomogeneous bulk density for alkaline batteries

The invention relates to zinc powders or zinc alloy powders with an inhomogeneous bulk density distribution depending on the particle size, wherein the difference of the bulk density measured according to ASTM B212 in the grain size range smaller than 75 µm and that in the grain size range greater than 150 µm is at least 0.5 g/cm3, and the mean bulk density of the powder, measured according to ASTM B212, ranges from 1.8 to 4.0 g/cm3. The invention is also directed to mixtures of said zinc powders or zinc alloy powders and to an alkaline battery including said powders.

Absorbent article with leg gasketing system

Disclosed is a pant type absorbent article having a skin facing side, a garment facing side, a longitudinal axis, a transverse axis, a pair of longitudinally extending side edges, and a pair of transversely extending end edges, a front belt and a back belt, the absorbent article comprising an absorbent body comprising: 1) a core chassis and 2) a leg gasketing system made by a pair of water impermeable cuff material disposed laterally outside and wrapping the pair of sides edges of the core chassis, the leg gasketing system comprising; 2a) a pair of wearer facing cuff regions formed by inwardly extending the cuff material over the wearer facing side of the core chassis; each of the pair of wearer facing cuff regions comprise a longitudinally extending inner cuff sealing and a longitudinally extending inner cuff free edge positioned inward from the inner cuff sealing, wherein the inner cuff sealing bonds the cuff material and the topsheet, and an inner cuff elastic element is disposed adjacent the inner cuff free edge; 2b) a pair of garment facing cuff regions formed by inwardly extending the cuff material over the garment facing side of the core chassis, and 2c) a pair of outer cuff elastic elements disposed on the wearer facing cuff regions or the garment facing cuff regions, each outer cuff elastic element disposed so as to superpose the core side regions and so as to superpose the inner cuff sealings or outward thereof; and wherein the absorbent article has a Worn Leg Opening (WLO) of from about 300mm to about 450mm, a Minimum Leg Opening (MLO) of from about 225mm to about 300mm, and a ratio of WLO/MLO of from about 1.5 to about 1.7.

MULTICOMPONENT KIT AND METHOD FOR STAINING KERATIN FIBERS

Multicomponent composition

The instant disclosure generally relates to a multicomponent composition for coating mammalian or synthetic keratin material and textiles, the composition comprising a first and second components and a third component. The first and second components comprise first and second compounds respectively. Any one or more of the first, second and third components may also comprise pigment microparticles. The first, second and third compounds meld together on keratin material and textiles and especially on hair to form a coating that can be formulated to provide temporary coverage or provide permanent coverage. The multicomponent composition formed and set in situ as a solid linked coating ranges from ready removability to substantially permanent lastingness.

3(5)-ureido-pyrazole derivatives, process for their preparation and their use as antitumor agents

3-ureido-pyrazole derivatives represented by formula (I): where R, R1 and R2 are as described herein, or pharmaceutically acceptable salts thereof; are useful, for example, for the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenerative diseases.

Plastic comprising zinc sulphide

3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents

Compounds which are 3-amino-pyrazole derivatives represented by formula (I) wherein R is C3-C6 cycloalkyl group optionally substituted by a straight or branched C1-C6 alkyl or arylalkyl group; R1 is a straight or branched C1-C6 alkyl, C2-C4 alkenyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, arylalkyl, arylcarbonyl, aryloxyalkyl or arylalkenyl group, each of which may be optionally further substituted as indicated in the description; or a pharmaceutically accept-able salt thereof. The compounds are useful for the treatment of cancer, cell pro-liferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenerative diseases.

Cutting device for straw cutting machines u. like

Novel skin care composition

The present invention generally relates to the field of skin care. More particularly, the invention relates to a cosmetic or therapeutic skin care composition comprising live bacteria of at least one Cutibacterium acnes (C. acnes) strain in combination with a thickener that specifically supports their viability during storage and/or their ability to replicate after application to the skin. Preferably, the cosmetic or therapeutic skin care composition comprises bacteria of at least one C. acnes strain selected from the group consisting of D1, A5, C1, C3, H1, H2,H3, K1,K2, K4, K6, K8, K9, L1, and F4.The invention also provides a method for treating or preventing acne by applying the skin care composition of the invention to a skin area in need of treatment. The invention also relates to the use of a skin care composition of the invention for treating or preventing acne.

Zinc powder or zinc alloy powder for alkaline batteries

The invention is directed to a zinc powder or zinc alloy powder for alkaline batteries, which powder has a grain size distribution wherein 60 to 100 wt.-% of the particles, relative to the zinc powder or zinc alloy powder, have a diameter of from 40 to 140 μm. The invention is also directed to an alkaline battery.

Purinones as ubiquitin-specific protease 1 inhibitors

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: (I), where R 1 , R 2 , R 3 , R 3' , R 4 , R 5 , X 1 , X 2 , X 3 , X 4 , and n are described herein.

NON-WATER, TOPIC COMPOSITIONS INCLUDING A HALOGENATED SALICYLANILIDE

ORNAMENTAL CONFIGURATION APPLIED TO THE TRAY

Observation device for pressurised gasifier - saves water cooling by ceramic lining and flushing gas

Observation device for the inside of a pressurised gasifier for solid fuels which is surrounded by an array of cooling tubes near its wall consists of a tube, carrying the observation instrument outside the gasifier, which is joined gasitight to a coaxial tube. The latter passes through a short branch pipe on the wall and is lined with a ceramic material of 15-25% emissive power, preferably alumina, zirconia or a white calcining clay. A recycled production gas can be introduced for flushing purposes. This does not require any additional water cooling which saves the constructional complications involved therein.

Purinones as ubiquitin-specific protease 1 inhibitors

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: (I), where R1, R2, R3, R3', R4, R5, X1, X2, X3, X4, and n are described herein.

Method for collecting data and sensor, data collector and measurement data information network

A method collects data via a sensor being part of a supply network which distributes a consumable. The sensor contains a measuring element which provides elementary measuring units, which correspond to a variable or a parameter, as raw measurement data, where consumption data are generated from the elementary measuring units. The sensor has a communication device and a storage device. To determine the measurement resolution of the sensor, the conditions for generating time stamps are determined using a correlation model. Time stamps of successive raw measurement data are generated in the sensor based on the correlation model, the time stamps are transmitted via a wired connection and/or via a radio path, with the result that the raw measurement data acquired by the measuring element are reconstructed and evaluated on the basis of the time stamps using the correlation model. The consumption data are transmitted in parallel with the time stamps.

Prodrugs of hiv reverse transcriptase inhibitors

Titanium dioxide-containing composite

Titanium dioxide-containing composites, methods for producing them and the use of the composites.

Neurological disease treatment with zilucoplan

The present disclosure relates methods of treating myasthenia gravis with zilucoplan (RA101495), including generalized myasthenia gravis. The present dislosure also claims devices and kits for zilucoplan administration and methods of evaluating complement inhibitor treatment efficacy.

3,6-diamino-pyridazin-3-yl derivatives, pharmaceutical compositions containing them and their uses as pro-apoptotic agents

Compuestos de fórmula (I) en donde Het1, Het2, R1, R2 y R3 son como se definen en la descripción. Medicamentos.

Method for producing a building door leaf, door leaf frame profile and door leaf

Die Erfindung betrifft ein Verfahren zur Herstellung eines Gebäudetür-Türblattes (12), insbesondere eines Haustür-Türblattes, wobei ein Türblatthohlraum (50) ausgebildet wird, der durch Schmalstirnseiten (35) bildende Seitenberandungen (44) und Türblattbreitseiten (34, 40) bildende Plattenelemente (42) begrenzt ist, wobei in den Türblatthohlraum (50) an wenigstens einer der Seitenberandungen (44) wenigstens eine sich entlang der Seitenberandungen (44) erstreckende, in den Türblatthohlraum (50) hineinragende, Vorsprungsausbildung (58) angeordnet ist, die den Plattenelementen (42) zugewandte Seitenflächen (59) hat, von denen sich wenigstens eine zu dem zugeordneten Plattenelement (42) derart schräg erstreckt, dass sich der Türblatthohlraum (50) von innen nach außen gesehen zu der Seitenberandung (44) hin verjüngt und wobei der Türblatthohlraum (50) ausgeschäumt wird. Weiter betrifft die Erfindung ein Türblattrahmenprofil (48) zur Verwendung in dem Verfahren sowie ein Türblatt (12), das mit einem solchen Verfahren erhältlich ist. The invention relates to a method for producing a building door leaf (12), in particular a front door leaf, wherein a door leaf cavity (50) is formed, by the narrow end faces (35) forming side edges (44) and door leaf broad sides (34, 40) forming plate elements (42), wherein in the door leaf cavity (50) on at least one of the side boundaries (44) at least one along the side edges (44) extending, in the door leaf cavity (50) protruding, protrusion formation (58) is arranged, which the plate elements (42) facing side surfaces (59), at least one of which extends obliquely to the associated plate member (42) such that the door leaf cavity (50) tapers from inside to outside towards the side boundary (44) and wherein the door leaf cavity (50) is foamed. Further, the invention relates to a door leaf frame profile (48) for use in the method and to a door leaf (12) obtainable by such a method.

Methods for testing surfaces using image processing

Die Erfindung betrifft die Objektivierung von (Oberflächen-)Prüfverfahren durch Bildverarbeitung. Dabei wird für jeden Bildpunkt (x,y) des Messfeldes einer untersuchten Probenoberfläche eine Information z (x,y) ermittelt und daraus werden Ergebnisgrößen errechnet. Es erfolgt eine objektive Korrelation dieser Ergebnisgrößeh mit einer Skala bisher subjektiv ermittelter Qualitätskennzahlen einer Eigenschaft der untersuchten Probe. Die Durchführung des Verfahrens bei der objektiven Beurteilung der Biegekante von Metallbändern und beim Verschleißtest an Metallbändern wird ausführlich beschrieben (Fig. 3). <IMAGE>

Zinc powder or zinc alloy powder for alkaline batteries

The invention is directed to a zinc powder or zinc alloy powder for alkaline batteries, which powder has a grain size distribution wherein 60 to 100 wt.-% of the particles, relative to the zinc powder or zinc alloy powder, have a diameter of from 40 to 140 μm. The invention is also directed to an alkaline battery.

Agrochemical formulation composition

The invention relates to an agrochemical formulation composition. The agrochemical formulation composition comprising at least one agrochemical active component and a solvent, which solvent comprises one or more dialkyl carbonates of the formula CO(ORa)(ORb), each of Ra and Rb being a linear or branched alkyl group of 3 to 6 carbon.

Barium sulfate-containing composite

A three-dimensional illuminated area for optical navigation

A navigation module for a handheld communication device having a navigation pad, a chrome-like area proximate the navigation pad, and a three-dimensional illumination area proximate the navigation pad. The three-dimensional illumination area can be interposed between the chrome-like area and the navigation pad. The chrome-like area can be interposed between the three-dimensional illumination area and the navigation pad.

3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents

Method for setting up and/or calibrating a robot

A method for setting up and/or calibrating a robot positioned in a work environment at an operation site, wherein a predetermined routine is carried out for the purposes of setting up and/or calibration. The method includes the steps of generating the routine for the robot at a simulation site distant from the operation site; after completing the generation of the routine, transmitting the routine to a control unit of the robot at the operation site; calling up the routine and remotely executing the routine at the operation site via a control center located remotely from the operation site; and, after the start of the generated routine, allowing the generated routine to automatically process without intervention by an operator at the operation site.

Prodrugs of hiv reverse transcriptase inhibitors

Compounds of Formula I are described: wherein R1 and R2 are defined herein. The compounds of Formula I are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV, and the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Neurological disease treatment with zilucoplan

The present disclosure relates methods of treating myasthenia gravis with zilucoplan (RA101495), including generalized myasthenia gravis. The present dislosure also claims devices and kits for zilucoplan administration and methods of evaluating complement inhibitor treatment efficacy.

Method for operating a consumption data collection system and data collector

Die Erfindung betrifft ein Verfahren zum Betrieb eines Verbrauchsdatenerfassungssystems, welches ein Head-End-System, mindestens einen, vorzugsweise eine Mehrzahl von Datensammler(n), sowie mindestens einen, vorzugsweise eine Mehrzahl von Verbrauchszähler(n) umfasst, wobei Daten, insbesondere verbrauchabhängige Daten, vom Verbrauchszähler über den Datensammler zum Head-End-System übertragen werden, wobei der Datensammler die vom Verbrauchszähler stammenden Daten erfasst und für die Übertragung an das Head-End-System vorhält, dadurch gekennzeichnet, dass die vom Verbrauchszähler stammenden Daten im Datensammler abgespeichert werden, nur ein Teil der vom Verbrauchszähler stammenden im Datensammler abgespeicherten Daten an das Head-End-System weitergeleitet wird, und eine Übertragung von Daten, die vorher nicht an das Head-End-System übertragen wurden, vom Datensammler zum Head-End-System vorgenommen wird. Ferner betrifft die Erfindung einen Datensammler mit einem Datenempfangsmodul zum Empfangen von Daten, insbesondere verbrauchabhängige Daten, von einem Verbrauchszähler, einem Datenverarbeitungsmodul zum Verarbeiten der empfangenen Daten, einem Datensendemodul zum Senden der verarbeiteten Daten, insbesondere an ein Head-End-System, und einem Speicher zum Vorhalten der an das Head-End-System zu übertragenden Daten, dadurch gekennzeichnet, dass die vom Verbrauchszähler stammenden Daten im Datensammler abgespeichert werden, nur ein Teil der vom Verbrauchszähler stammenden im Datensammler abgespeicherten Daten an das Head-End-System weitergeleitet werden, und eine Übertragung von Daten, die vorher nicht an das Head-End-System übertragen wurden, vom Datensammler zum Head-End-System vorgenommen wird, wobei der Datensammler nach mindestens einem der Verfahrensansprüchen betreibbar ist.

AGENT FOR DYING HAIR

Composites with good mechanical and tribological properties, useful e.g. for injection molding, comprise fine titanium dioxide particles in (thermo)plastic and/or epoxy resin matrix

New composites (I), of filler and pigment in polymer matrix type, contain (a) at least one of thermoplastics, high performance plastics and/or epoxy resins and (b) titanium dioxide (TiO 2) of average crystal size d 5 0 less than 350 (preferably 3-50) nm, optionally having an (in)organically modified surface. An independent claim is included for the production of (I), by producing a masterbatch from (b) and part of (a), then diluting with (a) while dispersing.

Plastic comprising zinc sulphide

The present invention relates to a plastic comprising zinc sulphide and to its use.

Patent DE3912336C2

Compositions for inhibiting ubiquitin specific protease 1

This disclosure relates to modulating ubiquitin specific protease 1 (USP1) and provides novel chemical compounds useful as inhibitors of USP1, as well as various uses of these compounds. USP1 inhibiting compounds are useful in the treatment of diseases and disorders associated with USP1, such as cancer.

Agrochemical formulation composition

The invention relates to an agrochemical formulation composition. The agrochemical formulation composition comprising at least one agrochemical active component and a solvent, which solvent comprises one or more dialkyl carbonates of the formula CO(OR

Pyrotechnic fire extinguisher for vehicle

Extincteur (1) pyrotechnique pour véhicule, comprenant un réservoir (10) pour un agent extincteur, le réservoir (10) comprenant un orifice d'expulsion (13) de l'agent extincteur et une colonne (30) plongeante tubulaire ouverte en une première extrémité (11) du réservoir (10) pour y introduire un générateur (40) d'un agent propulseur ;la colonne (30) plongeante étant en outre pourvue d'au moins un trou de diffusion (33), en une extrémité distale (32) de la colonne plongeante, et entourée d'une membrane (35) fixée sur la colonne (30) plongeante, ladite membrane étant configurée pour s'expandre à l'intérieur du réservoir de sorte à faire sortir l'agent extincteur par l'orifice d'expulsion ;l'extincteur (1) étant caractérisé en ce que des canaux (15), s'étendant en direction de la première extrémité (11) du réservoir (10), sont ménagés sur une paroi interne (14) du réservoir (10) ou sur une surface externe de la membrane (35). Figure à publier avec l’abrégé : Fig. 2 Pyrotechnic fire extinguisher (1) for a vehicle, comprising a tank (10) for an extinguishing agent, the tank (10) comprising an expulsion orifice (13) of the extinguishing agent and a tubular plunging column (30) open in a first end (11) of the reservoir (10) to introduce therein a generator (40) of a propellant; the immersed column (30) being further provided with at least one diffusion hole (33), at a distal end ( 32) of the immersion column, and surrounded by a membrane (35) fixed to the immersion column (30), said membrane being configured to expand inside the tank so as to release the extinguishing agent through the 'expulsion orifice; the extinguisher (1) being characterized in that channels (15), extending towards the first end (11) of the reservoir (10), are formed on an internal wall (14) of the reservoir (10) or on an outer surface of the membrane (35). Figure to be published with the abstract: Fig. 2

Surface treatment of particles and their use

The invention relates to the surface treatment of titanium dioxide, barium sulfate, zinc sulfide and/or lithopone particles, and to mixtures of these particles with special alkoxylated siloxanes for dispersion improvement in plastics.

Neurological disease treatment with zilucoplan

The present disclosure relates methods of treating myasthenia gravis with zilucoplan (RA101495), including generalized myasthenia gravis. The present dislosure also claims devices and kits for zilucoplan administration and methods of evaluating complement inhibitor treatment efficacy.

3 (5) -UREIDO-PYRAZOLE DERIVATIVES, THEIR MANUFACTURING METHOD AND THE USE THEREOF AS CANCER-INGREDIENT

Composition of agrochemical formulation

Composición de formulación agroquímica que comprende al menos un componente activo agroquímico y un disolvente, disolvente que comprende uno o más carbonatos de dialquilo de fórmula CO (ORa) (ORb), siendo cada uno de Ra y Rb un grupo alquilo lineal o ramificado de n carbonos, que tiene la fórmula general -CnH2n+1, seleccionándose n del grupo que consiste en 3, 4, 5 y 6. Agrochemical formulation composition comprising at least one agrochemical active component and a solvent, solvent comprising one or more dialkyl carbonates of formula CO (ORa) (ORb), each of Ra and Rb being a linear or branched alkyl group of n carbons, having the general formula -CnH2n + 1, n being selected from the group consisting of 3, 4, 5, and 6.

New Macrocyclic LRRK2 kinase inhibitors

Compounds of formula (I): wherein R, X1, X2, X3, Z1, Z2, Z3, A and Ra are as defined in the description. Medicaments.

purinones as inhibitors of ubiquitin-specific protease 1

a presente invenção refere-se a inibidores da usp1 úteis no tratamento de cânceres, e outras doenças e distúrbios associados à usp1, com a fórmula (i), onde r1, r2, r3, r3', r4, r5, x1, x2, x3, x4, e n são descritos neste documento. The present invention relates to usp1 inhibitors useful in the treatment of cancers, and other usp1-associated diseases and disorders of formula (i), wherein r1, r2, r3, r3 ', r4, r5, x1, x2, x3, x4, and n are described in this document.

3,6-diamino-pyridazin-3-yl derivatives, pharmaceutical compositions containing them and their uses as pro-apoptotic agents

Compounds of formula (I) wherein Het 1 , Het 2 , R 1 , R 2 and R 3 are as defined in the description. Medicaments.

Method for collecting data in a network, sensor, consumption meter, temporary receiver and network

The present invention provides a method for collecting data in a network, preferably data in connection with a consumption, a physical or physicochemical parameter and/or an operating state in the context of an operation of a local sensor (1), preferably a sensor (1) for a consumption meter (10) as part of a supply network comprising at least one local sensor (1), preferably a plurality of local sensors (1) for the distribution of a consumable good, with a plurality of sensors (1), whereas the sensor (1) contains at least one measuring element (9), the measuring element (9) of the respective sensor (1) provides an elementary measuring units in the form of raw measurement data which corresponds to at least one physical or physicochemical value or at least one physical or physicochemical parameter, and the sensor (1) comprises wired and/or radio communication means (2) and memory means (7), characterized in that for the determination of the measurement resolution of the sensor (1) the conditions for generating time stampings (TS) using a correlation model are determined in advance, on the basis of the correlation model time stampings (TS) of successive raw measurement data in the sensor (1) are generated, the time stampings (TS) are stored in the memory means (7) of the consumption meter (10), the time stampings (TS) are transmitted over a wired connection and/or a radio link so that on the basis of the time stampings (TS) using the correlation model the raw measurement data collected by the measuring element (9) are reconstructed and evaluated, whereas raw measurement data is used for on- demand network analysis. Furthermore, the present invention provides a sensor (1), a consumption meter (10) and a temporary receiver (50), which can be operated according to a method according to at least one of the method claims. In addition, the present invention provides a network, in which the raw measurement data are used for on-demand network analysis, and the network is ...

Method for collecting data in a network, sensor, consumption meter, temporary receiver and network

The present invention provides a method for collecting data in a network, preferably data in connection with a consumption, a physical or physicochemical parameter and/or an operating state in the context of an operation of a local sensor (1), preferably a sensor (1) for a consumption meter (10) as part of a supply network comprising at least one local sensor (1), preferably a plurality of local sensors (1) for the distribution of a consumable good, with a plurality of sensors (1), whereas the sensor (1) contains at least one measuring element (9), the measuring element (9) of the respective sensor (1) provides an elementary measuring units in the form of raw measurement data which corresponds to at least one physical or physicochemical value or at least one physical or physicochemical parameter, and the sensor (1) comprises wired and/or radio communication means (2) and memory means (7), characterized in that for the determination of the measurement resolution of the sensor (1) the conditions for generating time stampings (TS) using a correlation model are determined in advance, on the basis of the correlation model time stampings (TS) of successive raw measurement data in the sensor (1) are generated, the time stampings (TS) are stored in the memory means (7) of the consumption meter (10), the time stampings (TS) are transmitted over a wired connection and/or a radio link so that on the basis of the time stampings (TS) using the correlation model the raw measurement data collected by the measuring element (9) are reconstructed and evaluated, whereas raw measurement data is used for on- demand network analysis. Furthermore, the present invention provides a sensor (1), a consumption meter (10) and a temporary receiver (50), which can be operated according to a method according to at least one of the method claims. In addition, the present invention provides a network, in which the raw measurement data are used for on-demand network analysis, and the network is ...

3 (5) -aminopyrazole derivatives, the process for their preparation and their use as antitumor agents

Dye-containing pellets and their use

The present patent application relates to dye-containing pellets obtained by (a) homogeneous mixing of a starting material containing at least one natural and/or synthetic dye with a suitable carrier material and then coating with a suitable encapsulation material or (b) coating a suitable carrier material with a mixture of at least one natural and/or synthetic dye and at least one suitable encapsulation material, to the use of said pellets for preparing colorants for keratin fibers and to the colorants based on said pellets. Furthermore the present patent application relates to the use of these pellets for increasing the shine of the keratin fibers, reducing the scalp coloring of hair dyes, improving the protection for the cortex, increasing the colorant efficiency and reducing the load of colorants, and improving the wash resistance.

Machine learning methods and systems for determining file risk using content disarm and reconstruction analysis

File risk and malware detection and classification can be enhanced using machine learning analysis of content disarm and reconstruction (CDR) output. Correlations can be discovered or analyzed between individual elements of such outputs, which can include an XML report. Such correlations can provide useful information on threat intelligence and help validate content disarm and reconstruction. A method can include training machine learning algorithms with a dataset derived from CDR results from test files labelled as malicious or not malicious; instructing algorithms to predict probabilities; and determining correlation between the report items and malware (for example, using the function feature importances and the SHAP value method).

Method for manufacturing a building door leaf, door leaf frame and door leaf

The method involves forming a door cavity (50) defined by narrow front end (35) forming the side boundaries (44) and the door leaf broad sides (34,40) forming the plate elements (42). A projecting formation (58) is extended into the door cavity along the side boundary. The side surface (59) of the projecting formation is extended diagonally into the door cavity. The door cavity is filled with foam. Independent claims are included for the following: (1) a door leaf frame; and (2) a door leaf.

Zinc powder or zinc alloy powder for alkaline batteries

Zinc powder or zinc alloyed powder is used as an electrode and has a grain size distribution, in which 75-95 weight percent of particles have a diameter of between 40 and 140 microns. Settled apparent density lies in a range of between 2.9 and 4.5 g/cm3. Metals are chosen as alloyed elements from a group including indium, bismuth, lead, aluminum, calcium, lithium, sodium, magnesium and mixtures. An Independent claim is also included for an alkali battery with zinc powder as an anode.

Method for manufacturing a building door leaf, door leaf frame and door leaf

Die Erfindung betrifft ein Verfahren zur Herstellung eines Gebäudetür-Türblattes (12), insbesondere eines Haustür-Türblattes, wobei ein Türblatthohlraum (50) ausgebildet wird, der durch Schmalstirnseiten (35) bildende Seitenberandungen (44) und Türblattbreitseiten (34, 40) bildende Plattenelemente (42) begrenzt ist, wobei in den Türblatthohlraum (50) an wenigstens einer der Seitenberandungen (44) wenigstens eine sich entlang der Seitenberandungen (44) erstreckende, in den Türblatthohlraum (50) hineinragende, Vorsprungsausbildung (58) angeordnet ist, die den Plattenelementen (42) zugewandte Seitenflächen (59) hat, von denen sich wenigstens eine zu dem zugeordneten Plattenelement (42) derart schräg erstreckt, dass sich der Türblatthohlraum (50) von innen nach außen gesehen zu der Seitenberandung (44) hin verjüngt und wobei der Türblatthohlraum (50) ausgeschäumt wird. Weiter betrifft die Erfindung ein Türblattrahmenprofil (48) zur Verwendung in dem Verfahren sowie ein Türblatt (12), das mit einem solchen Verfahren erhältlich ist.

Card adaptor apparatus

Card adaptor apparatus are disclosed herein. An example card adaptor apparatus includes a first frame having an outer perimeter configured to define a first card and an opening configured to receive a second card having a dimensional profile that is smaller than a dimensional profile of the first card. A first adhesive substantially spans across the entire opening of the first adaptor to retain the second card in the opening of the first frame.

Process for the preparation of secondary or tertiary amines

Use of pyrrolidinone carboxylic acids and polymers

The wash fastness of dyed fibers, especially keratin fibers, can be increased substantially by means of a combination of active ingredients comprising pyrrolidinone carboxylic acid and a natural or synthetic cationic or amphoteric polymer.

Purinones as ubiquitin-specific protease 1 inhibitors

【課題】ユビキチン特異的プロテアーゼ１阻害剤としてのプリノンを提供すること。【解決手段】本出願は、式（Ｉ）を有する、がん及び他のＵＳＰ１に関連する疾患及び障害の治療に有用なＵＳＰ１の阻害剤に関し、式中、Ｒ１、Ｒ２、Ｒ３、Ｒ３’、Ｒ４、Ｒ５、Ｘ１、Ｘ２、Ｘ３、Ｘ４、及びｎは本明細書に記載されるとおりである。本出願は、ユビキチン特異的プロテアーゼ１（ＵＳＰ１）酵素に関連する疾患または障害の治療に有用な、ＵＳＰ１の阻害剤を対象とする。詳細には、本出願は、ＵＳＰ１を阻害する化合物及びその組成物、ＵＳＰ１に関連する疾患または障害の治療方法、ならびにこれらの化合物の合成方法に関する。TIFF2023011899000384.tif4885【選択図】なし

House door leaf and method for manufacturing same

Surface treatment of particles and their use

The invention relates to the surface treatment of titanium dioxide, barium sulfate, zinc sulfide and/or lithopone particles, and to mixtures of these particles with special alkoxylated siloxanes for dispersion improvement in plastics.

Prodrugs of hiv reverse transcriptase inhibitors.

Se describen compuestos de fórmula I, (ver Fórmula]) en donde R1 y R2 se definen en la presente; los compuestos de fórmula I son útiles en la inhibición de la transcriptasa inversa del VIH, la profilaxis y el tratamiento de la infección por el VIH, y la profilaxis, la demora en el inicio o la progresión y el tratamiento del SIDA; los compuestos pueden usarse como ingredientes en composiciones farmacéuticas, opcionalmente en combinación con otros antivirales, inmunomoduladores, antibióticos o vacunas.

Blowing catalyst

Composition containing prebiotic bacteria and protector strains

Die vorliegende Erfindung betrifft eine kosmetische oder dermatologische Zusammensetzung, die mindestens einen probiotisch wirksamen Bakterienstamm, der bei Ansiedlung auf der Haut die Hautgesundheit positiv beeinflusst, einen Protektor-Stamm der Gattung Lactobacillus und mindestens einen kosmetischen Hilfsstoff umfasst. Die Erfindung betrifft ferner ein Verfahren zur kosmetischen oder dermatologischen Behandlung der Haut, bei dem man die Zusammensetzung der vorliegenden Erfindung auf die Haut aufträgt. Die Erfindung betrifft ferner auch ein Verfahren zur Herstellung der kosmetischen oder dermatologischen Zusammensetzung der vorliegenden Erfindung.

Transport bed manipulator

Titanium dioxide-containing composite

The invention relates to titanium dioxide-containing composites, to methods for producing the same and to the use of said composites.