Tank Device, in Particular in a Vehicle

A tank device, in particular in a vehicle, has a pressure tank for storing fuel and a fuel line for filling the pressure tank which extends from outside of the pressure tank through a tank opening up to a free line end in the interior of the pressure tank. The fuel line in the pressure tank has at least one line outlet through which the fuel can flow out of the fuel line into the pressure tank. The fuel line, between the tank opening and the free line end, has a flexible line section such that the flexible line section moves when the pressure tank is filled.

Sagger receiving element, in particular a sagger for burning powdery cathode material for lithium-ion accumulators, and mixture therefor

A sagger receiving element for burning powdery cathode materials for producing lithium ion accumulators including a rectangular shell comprising four side walls and a base, wherein the sagger receiving element is produced by a burning process from heat-resistant material which withstands temperatures of in particular more than 900° C., and wherein the material of the sagger receiving element is produced on the basis of oxide-bonded SiC, the material having the following chemical composition in percent by weight to a total of 100%: silicon carbide (SiC) content in a range of 40.0%-80.0%, Al 2 O 3 content in a range of 10%-43%, total SiO 2 content in a range of 5%-30%, and alkali oxide and iron oxide content of less than 2%.

Device for dispensing coins

A device for dispensing coins includes a rotatingly-driven rotary disk, a coin container arranged above the rotary disk, through which coins are fed to a top side of the rotary disk, and a coin discharge. A wiper device is also includes and comprises at least one elastic wiper arm arranged above and at a distance from the top side of the rotary disk and turning with the rotary disk.

Peptide mimotopes of claudin 18.2 and uses thereof

The present invention provides molecules that mimic antigenic determinants of the integral transmembrane protein claudin 18.2 (CLDN18.2). These molecules compete with CLDN18.2 for binding to a CLDN18.2 binding domain, e.g. a CLDN18.2 binding domain of an antibody, and are capable of detecting antibodies against CLDN18.2. The mimotopes of the invention may be used to generate or inhibit immune responses in animals and preferably humans. Furthermore, they can be used for purposes of detecting agents comprising a CLDN18.2 binding domain in biological samples as well as for purifying agents comprising a CLDN18.2 binding domain.

Substituted benzimidazole

Substituted indoles for modulating nfkb activity, process for their preparation and pharmaceutical compositions containing them and their use

A találmány új, (I) általános képletű szubsztituáltindolszármazékokra, előállításukra és gyógyszerkénti alkalmazásukravonatkozik. Az új vegyületek olyan betegségek megelőzésére éskezelésére alkalmazhatók, amelyek lefolyásában az NFKB fokozottaktivitású. A vegyületek fajlagosan gátolják az IKB-kinázt. Az (I)általános képletben R1, R2, R3 és R4 szubsztituens közül az egyikjelentése (II) általános képletű csoport, amelyben R7 hidrogénatomotvagy alkilcsoportot jelent, R8 jelentése R9 vagy aminosavmaradék; R9adott esetben szubsztituált aril-, 5-14 gyűrűtagú heteroaril-, 5-12gyűrűtagú heterociklusos- vagy alkilcsoportot jelent, R5 jelentésehidrogénatom, hidroxicosport vagy =O és R6 jelentése adott esetbenszubsztituált aril-, heteroaril- vagy heterociklusos csoport. Ó The present invention relates to novel substituted indole derivatives of formula (I), to their preparation and to their use as a medicament. The novel compounds are useful in the prevention and treatment of diseases in which NFKB is highly active. The compounds specifically inhibit IKB kinase. In the formula (I), one of the substituents R1, R2, R3 and R4 represents a group of the formula (II) in which R7 is hydrogen or alkyl, R8 is R9 or an amino acid residue; R9 is optionally substituted aryl, 5-14 ring heteroaryl, 5-12 ring heterocyclic or alkyl, R5 is hydrogen, hydroxy or = O and R6 is optionally substituted aryl, heteroaryl or heterocyclic. HE

Process for dyeing cellulosic textile materials

Cellulosic textile material is dyed with substantive dyes or preferably with reactive dyes. Dyeing is carried out by applying to the cellulosic material, by a non-pad method, an aqueous dye liquor which contains, in addition to the dye, a graft polymer which is obtained from an adduct of an alkylene oxide, preferably propylene oxide, with an at least trihydric aliphatic alcohol, e.g. glycerol, and acrylamide or methacrylamide. The cellulosic material is then subjected to a heat treatment, e.g. by steaming or with microwaves, or is preferably stored cold, to fix the dyes. This dyeing process affords dyeings with excellent penetration of the fabric and with level depth of shade from edge to edge.

Process for pad dyeing cellulosic textile materials

Cellulosic textile material is dyed with substantive dyes or preferably with reactive dyes. Dyeing is carried out by applying to the cellulosic material an aqueous dye liquor which contains, in addition to the dye, a graft polymer which is obtained from an adduct of an alkylene oxide, preferably propylene oxide, with an at least trihydric aliphatic alcohol, e.g. glycerol, and acrylamide or methacrylamide. The cellulosic material is then subjected to a heat treatment, e.g. by steaming or with microwaves, or is stored cold, to fix the dyes. This dye liquor increases the liquor pick-up and thus also increases the dye yield, while at the same time excellent levelness is achieved.

Dyeing process using graft polymers which are water soluble or dispersible in water as dyeing assistants

Graft polymers which are obtainable from (A) 2-30% by weight of an addition product from alkylene oxide onto an aliphatic alcohol which is at least trihydric having 3 to 10 carbon atoms and (B) 70-98% by weight of a grafted-on monomer mixture of (1) 20 to 50% by weight of an N-substituted or N-unsubstituted acrylamide or methacrylamide and (2) 50 to 80% by weight of an N-vinyl-substituted amide or of a vinyl ester, derived in each case from a saturated aliphatic monocarboxylic acid, where the sums of (A) and (B), and (1) and (2) in each case add up to 100%. These novel graft polymers are suitable as dyeing assistants, particularly as padding assistants or liquor binders when dyeing cellulose fibre materials.

Process for pad dyeing cellulosic textile materials

Cellulosic textile material is dyed with substantive dyes or preferably with reactive dyes. Dyeing is carried out by applying to the cellulosic material an aqueous dye liquor which contains, in addition to the dye, a graft polymer which is obtained from an adduct of an alkylene oxide, preferably propylene oxide, with an at least trihydric aliphatic alcohol, e.g. glycerol, and acrylamide or methacrylamide. The cellulosic material is then subjected to a heat treatment, e.g. by steaming or with microwaves, or is stored cold, to fix the dyes. This dye liquor increases the liquor pick-up and thus also increases the dye yield, while at the same time excellent levelness is achieved.

Method and circuit for testing coins

The method involves using an inductive sensor arrangement which comprises a primary coil and a secondary coil, whose field is traversed by a coin. The primary coil is supplied with a periodical transmitter signal which contains preferably harmonics, and an evaluation circuit evaluates the signals of the secondary coil to produce an acceptance- or rejection signal. A periodically recurring section of the transmitter signal is associated with an amount of switching steps, envelope curves are formed from the values of the reception signal of secondary coil at the respective recurring switching steps, and the evaluation circuit forms at least one criterion for the acceptance- or rejection signal from the amount of contemporaneously produced envelope curves.

Substituted benzimidazole

New aminoacid residue substituted benzimidazole derivative I(kappa)B-kinase inhibitors, useful for treating NF(kappa)B-related disorders e.g. rheumatoid arthritis, asthma, Alzheimer's disease and cancer

Benzimidazole derivatives (I), containing an aminoacid residue N-bonded via a carbonyl, sulfinyl or sulfonyl group, are new. Benzimidazoles of formula (I), containing an aminoacid residue N-bonded via a carbonyl, sulfinyl or sulfonyl group and their stereoisomers and salts are new. At least one of R1-R4 = -D-N(R8)-CHR9-CO-R10 and the other(s) are H, halo, alkyl, CN, NO2, aryloxy, aralkoxy, alkoxy, OH, N(R11)2, SR11 or CF3, provided that not more than two are other than H, halo or alkyl; D = CO, SO or SO2; R8 = H or alkyl; R9 = characteristic residue of an aminoacid; optionally substituted Q; 1-6C alkyl substituted by 1 or 2 of optionally substituted Q, OR11, =O, SOR11, SO2R11, SR11, N(R11)2 and 3-6C cycloalkyl; or alkyl, or R8-R9 = -A-X-Y-B-, with the obtained ring system optionally substituted by 1-3 of 1-8C alkyl (optionally substituted by 1 or 2 OH), 1-8C alkoxy, halo, NO2, NH2, CF3, OH, OCH2O, COMe, CHO, CN, COOH, CONH2, alkoxycarbonyl, Ph, OPh, CH2Ph, OCH2Ph and tetrazolyl; R10 = OR11 or N(R11)2; R11 = H, alkyl (optionally substituted by Q) or Q, or R9-R10 = -T-V-W-N(R11)-, with the obtained ring system optionally substituted as for that formed by -R8-R9-; Q = aryl, 5-14 membered heteroaryl or 5-12 membered heterocyclyl; A = N or CH2; B, X, T, W = O, S, N or CH2; Y, V = a direct bond or as for B; or X + Y, T + V or V + W = phenyl or 1,2-, 1,3- or 1,4-diazine residue; R5 = H, OH or =O; R6 = phenyl, substituted by 1 or 2 of CN, NO2, alkoxy, N(R11)2, NHCOR11, SR11, COR11 and aminoalkyl; or 5-14 membered heteroaryl or 5-12 membered heterocyclyl, both optionally having 1-3 substituents; provided that rings formed by R8 + R9 or R9 + R10 contain 0 or 1 O or S and 1-4 N; alkyl moieties have 1-4C unless specified otherwise. An Independent claim is included for the preparation of (I).

Substituted benzimidazole

The invention relates to compounds of formula (I) which are suitable for producing medicaments. Said medicaments are used in the prophylaxis and treatment of diseases, in the course of which there is increased activity of NFkB.

Substituted benzimidazoles

Compounds of formula I are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of NFκB is involved.

Substituted benzimidazole

Substituted benzimidazole

substituted benzimidazoles.

Substituted benzimidazoles

Compounds of the formula I (see formula I) are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of NF .KAPPA. B is involved.

Substituted benzimidazoles

SUBSTITUTED BENCIMIDAZOLS.

Compuesto de la fórmula I y/o una forma estereoisomérica del compuesto de la fórmula I y/o una sal fisiológicamente tolerable del compuesto de la fórmula I, en la que uno de los sustituyentes R 1 , R 2 , R 3 y R 4 es un radical de la fórmula II, en la que significan D es -C(O)-, -S(O)- o -S(O)2-, R 8 es átomo de hidrógeno o alquilo (C1-C4), R 9 es 1. un radical característico de un aminoácido, que se deriva de un -aminoácido natural del grupo alanina, va-lina, leucina, isoleucina, fenilalanina, tirosina, triptófano, serina, treonina, cisteína, metionina, asparagina, glutamina, lisina, histidina, arginina y ácido glutámico, 2. un radical característico de un aminoácido, que se deriva de un aminoácido no natural del grupo ácido 2-aminoadípico, ácido 2-aminobutírico, ácido 2-aminoisobutírico, ácido 2, 3-diamino-propiónico, ácido 2, 4-diaminobutírico, ácido 1, 2, 3, 4-tetra-hidroisoquinolin-1-carboxílico, ácido 1, 2, 3, 4- tetrahidroisoquinolin-3- carboxílico, ácido 2-amino-pimélico, fenilglicina, 3-(2-tienil)-alanina, 3-(3-tienil)-alanina, sarcosina, 2-(2- tienil)-glicina, ácido 2-aminoheptanoico, ácido pipecolínico, hidroxilisina, N-metiliso-leucina, 6-N-metil-lisina, N-metilvalina, norvalina, norleucina, ornitina, alo-isoleucina, 4-hidroxiprolina, alo-hidroxilisina, alo-treonina, 3-hidroxiprolina, 3-(2-naftil)-alanina, 3-(1-naftilalanina), homofenilalanina, homocisteína, ácido 2-amino-3-fenilaminoetilpropiónico, ácido homocisteínico, homotriptófano, ácido cisteínico, 3-(2-piridil)- alanina, 3-(3-piridil)-alanina, 3-(4-piridil)-alanina, fosfinotricina, 4-fluorofenilalanina, 3-fluorofe-nilalanina, 2-fluorofenilalanina, 4-clorofenilalanina, 4-nitrofenilalanina, 4-aminofenilalanina, ciclohexila-lanina, citrulina, 5-fluorotriptófano, 5-metoxitriptófano, ácido 2-amino-3-fenilaminopropiónico, sulfona de metionina, sulfóxido de metionina o -NH-NR 11 -CON(R 11 )2, Compound of formula I and / or a stereoisomeric form of the compound of formula I and / or a physiologically ...

Substituted benzimidazole

Substituted benzimidazoles

The invention relates to compounds of formula (I) which are suitable for producing medicaments. Said medicaments are used in the prophylaxis and treatment of diseases, in the course of which there is increased activity of NFkB.

Benzimidazoles substituidos

Substituted benzimidazole

Substituted benzimidazole, process for preparing them, their use and pharmaceutical compositions containing these compounds

The invention relates to compounds of formula (I) which are suitable for producing medicaments. Said medicaments are used in the prophylaxis and treatment of diseases, in the course of which there is increased activity of NFkB.

Substituted indoles

The invention relates to compounds of formula (I) which are suitable for the production of medicaments for the prophylaxis and treatment of disease states, the course of which involves increased NFkB activity. The compounds are specific IkB-kinase inhibitors.

Substituted benzimidazole

Substituted benzimidazole, process for preparing them, their use and pharmaceutical compositions containing these compounds

The invention relates to compounds of formula (I) which are suitable for producing medicaments. Said medicaments are used in the prophylaxis and treatment of diseases, in the course of which there is increased activity of NFkB.

Substituted benzimidazoles

Compounds of the formula I (see formula I) are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of NF .KAPPA. B is involved.

Substituted benzimidazoles

Substituted benzimidazole

The invention relates to compounds of formula (I) which are suitable for producing medicaments. Said medicaments are used in the prophylaxis and treatment of diseases, in the course of which there is increased activity of NFkB.

Supstituisani benzimidazoli

Pronalazak se odnosi na jedinjenja formule (I) koja su pogodna za izradu lekova za profilaksu i za terapiju oboljenja na čiji razvoj utiče pojačano delovanje NFκB.

Substituted benzimidazole.

Substituted benzimidazoles

The invention relates to compounds of formula (I) which are suitable for producing medicaments. Said medicaments are used in the prophylaxis and treatment of diseases, in the course of which there is increased activity of NFkB.

INDOLES REPLACED FOR THE MODULATION OF NFKB ACTIVITY.

Compuesto de la fórmula I **(Ver fórmula)** y/o una forma estereoisómera del compuesto de la fórmula I y/o una sal fisiológicamente tolerable del compuesto de la fórmula I, en donde R3 representa un radical de la fórmula II, **(Ver fórmula)** en donde D representa -C(O)- , R7 representa átomo de hidrógeno o alquilo (C1-C4), R8 representa 1. alquilo (C1-C4), en donde alquilo es lineal o ramificado y está mono- o disustituido, de manera independiente entre sí, con 1.1 heteroarilo con 5 a 14 miembros de anillo o heterociclo con 5 a 12 miembros de anillo, en donde heteroarilo y heterociclo han sido seleccionados del grupo de pirrol, piridina, pirazina, furano, tiofeno, imidazol, pirazol, oxazol, isoxazol, tiazol, isotiazol, tetrazol, triazolonas, 2-óxidos de 1,2,3,5-oxatiadiazol, oxadiazolonas, isoxazolonas, oxadiazolidindionas, triazoles, que están sustituidos con F, -CN, -CF3 ó -C(O)-O-alquilo (C1-C4), 3-hidroxipirrol-2,4-dionas, 5-oxo-1,2,4- tiadiazoles, pirimidina, indol, isoindol, indazol, ftalazina, quinoleína, isoquinoleína, quinoxalina, quinazolina, cinolina, carbolina, y derivados benzo-condensados, ciclopenta-, ciclohexa- y ciclohepta-condensados de estos heterociclos, 1.2 -O-R10, 1.3 -S(O)x-R10, en donde x es el número entero cero, 1 ó 2, 1.4 -N(R10)2, 1.5 radical de la fórmula **(Ver fórmula)** ó 1.6 radical de la fórmula **(Ver fórmula)** o bien 2. representa el radical característico de un aminoácido del grupo de glicina, alanina, valina, leucina, isoleucina, fenilalanina, tirosina, serina, triptófano, treonina, cisteína, metionina, asparagina, glutamina, lisina, histidina, arginina, ácido glutámico, ácido aspártico, ácido 2-aminoadípco, ácido 2-aminoisobutírico, ácido 2-aminobutírico, ácido 2,3-diamino-propiónico, ácido 2,4-diaminobutírico, ácido 1,2,3,4- tetrahidroisoquinolin-1-carboxílico, ácido 1,2,3,4-tetrahidroisoquinolin-3-carboxílico, ácido 2-aminopimélico, fenilglicina, 3-(2-tienil)-alanina, 3-(3-tienil)-alanina, 2-(2-tienil)-glicina, ácido 2- ...

Substituted indoles for modulating nfkb activity

The invention relates to compounds of formula (I) which are suitable for the production of medicaments for the prophylaxis and treatment of disease states, the course of which involves increased NFkB activity. The compounds are specific IkB-kinase inhibitors.

Substituted indoles for modulating nfkb activity

The invention relates to compounds of formula (I) which are suitable for the production of medicaments for the prophylaxis and treatment of disease states, the course of which involves increased NFkB activity. The compounds are specific IkB-kinase inhibitors.

Substituted indoles for modulating NFkB activity

substituted indoles for modulating nfkb activity.

Substituted indoles for modulating nfkb activity

The invention relates to compounds of formula (I) which are suitable for the production of medicaments for the prophylaxis and treatment of disease states, the course of which involves increased NFkB activity. The compounds are specific IkB-kinase inhibitors.

SUB-SUBSTITUTE INDICATORS FOR NFKB-ENERGY CONSTRUCTION

Οι ενώσεις του τύπου (I) είναι κατάλληλες για την παραγωγή φαρμακευτικών μέσων για την προφύλαξη και θεραπεία παθήσεων, στην εξέλιξη των οποίων εμπλέκεται ενισχυμένη ενεργότητα του NFκB. Οι ενώσεις είναι ειδικοί αναστολείς της ΙκΒ-κινάσης. The compounds of formula (I) are suitable for the manufacture of pharmaceuticals for the prophylaxis and treatment of diseases involving the development of enhanced NFκB activity. The compounds are specific IκB-kinase inhibitors.

Substituted indole, process for its preparation pharmaceutical composition in which the indole is comprised, the use of the indole for the preparation of a medicament and process for preparing the medicament

The present invention relates substituted indoles of the general formula (I), in which the individual substituents have specifically defined meanings, as well as to pharmaceutical compositions in which the indole is comprised as an active substance, further to the use of the said indole for the production of a medicament intended for the prophylaxis and treatment of disease states, the course of which involves increased NF{kappa}B activity. The invention also relates to the process for preparing of the said medicament.

Substituted indoles for modulating NFKB activity

Substituted indoles.

Compounds of the formula I are suitable for preparing pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of NFkappaB is involved.

Substituted indoles for modulating NFKB activity

IKB kinase inhibitor compounds of formula (I), the preparation thereof, and the use of such compounds in treating disorders where an increased activity of NFKB is involved are disclosed, wherein the substituents are as defined in the specification.

SUBSTITUTED INDOLES FOR MODULATING NFkB ACTIVITY

The invention relates to compounds of formula (I) which are suitable for the production of medicaments for the prophylaxis and treatment of disease states, the course of which involves increased NFkB activity. The compounds are specific IkB-kinase inhibitors.

Indoles substituídos para a modulação da actividade do nfκb

Substituted indoles for modulating nfkb activity

Substituted indoles for modulating NFkB activity, a method for producing them, a medicament containing them and the use of them

The invention relates to compounds of formula (I) which are suitable for the production of medicaments for the prophylaxis and treatment of disease states, the course of which involves increased NFkB activity. The compounds are specific IkB-kinase inhibitors.

SUBSTITUTED INDOLE FOR MODULATING NFKB ACTIVITY

Substituted indoles

Compounds of the formula I are suitable for preparing pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of NFκB is involved.

Substituted indoles for modulating nfkb activity

Compounds of the formula I are suitable for preparing pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of NFkappaB is involved.

SUBSTITUTED INDOLES FOR MODULATING NFkB ACTIVITY

Substituted indoles

The invention relates to compounds of formula (I) which are suitable for the production of medicaments for the prophylaxis and treatment of disease states, the course of which involves increased NFkB activity. The compounds are specific IkB-kinase inhibitors.

Substituted indoles for modulating nfkb activity

The invention relates to compounds of formula (I) which are suitable for the production of medicaments for the prophylaxis and treatment of disease states, the course of which involves increased NFkB activity. The compounds are specific IkB-kinase inhibitors.

Substituted indoles for modulating nfkb activity

The invention relates to compounds of formula (I) which are suitable for the production of medicaments for the prophylaxis and treatment of disease states, the course of which involves increased NFkB activity. The compounds are specific IkB-kinase inhibitors.

Supstituisani indoli za moduliranje nfkb aktivnosti

Jedinjenja formule (I) podesna su za proizvodnju lekova za profilaksu i lečenje oboljenja na čiji tok utiče pojačana NFkB-aktivnost. Ova jedinjenja su specifični inhibitori IkB-kinaze.[The invention relates to compounds of formula (I) which are suitable for the production of medicaments for the prophylaxis and treatment of disease states, the course of which involves increased NFkB activity. The compounds are specific IkB-kinase inhibitors.

Substituted indoles for modulating nfkb activity

The invention relates to compounds of formula (I) which are suitable for the production of medicaments for the prophylaxis and treatment of disease states, the course of which involves increased NFkB activity. The compounds are specific IkB-kinase inhibitors.

Hot melt pressure sensitive adhesive composition useful for contact coating on heat sensitive substrates

The invention is a disposable article comprising a discontinuous coating of a hot melt PSA permanently adhered to at least one substrate wherein the adhesive has a shear adhesion failure temperature of greater than about 79° C. (175° F.). Preferably, the adhesive is pattern coated directly onto a polyolefin film for use in a variety of articles including adhesive bandages, tape and feminine napkins.

Apparatus for welding thermoplastic plastic parts forming a hollow body by means of laser radiation

Vorrichtung zum Verschweißen von mehreren einen Hohlkörper mit einer Öffnung bildenden thermoplastischen Kunststoffteilen mit einer Einrichtung zum ortsfesten Halten des aus den Fügeteilen zusammengesetzten Hohlkörpers, einer Einrichtung zur Erzeugung einer Kraft, welche die eine Fügezone bildenden Fügeflächen der Fügeteile zusammenpresst und einem Werkzeugkopf, der entlang der Fügezone geführt wird und die zur Verschweißung führende Laserstrahlung in die Fügezone einbringt, wobei die Einrichtung zum Halten und die Einrichtung zur Erzeugung einer Kraft ein einziger Vakuumhalter (1) ist, der eine mit einer Vakuumpumpe (4) in Verbindung stehende, einseitig offene Vakuumkammer (2) aufweist, die gemeinsam mit dem Hohlkörper eine geschlossene evakuierbare Kammer bildet, dadurch gekennzeichnet, dass die offene Seite der Vakuumkammer (2) in ihrem Querschnitt kleiner als die Öffnung des Hohlkörpers ausgeführt ist und der Hohlkörper über eine die Öffnung bildende Abschlussfläche auf einer die offene Seite der Vakuumkammer (2) umschließenden Abdichtscheibe (3) aufliegt. Device for welding a plurality of thermoplastic parts forming a hollow body with an opening with a device for stationary holding of the hollow body composed of the parts to be joined, means for generating a force which compresses the joining surfaces of the joining parts forming a joining zone and a tool head along the joining zone is guided and introduces the leading to the welding laser radiation in the joining zone, wherein the means for holding and the means for generating a force is a single vacuum holder (1) having a vacuum pump (4) in connection, one-sided open vacuum chamber (2 ), which together with the hollow body forms a closed evacuable chamber, characterized in that the open side of the vacuum chamber (2) is designed smaller in cross-section than the opening of the hollow body and the hollow body via a Abschlussf forming the opening Surface on a the open side of the vacuum chamber (2) enclosing ...

Apparatus for welding thermoplastic parts forming a hollow article by laser radiation

A vacuum chamber (2) is open on one side, which is then closed by placing the components (8, 9) to be welded in position. The vacuum produced by a pump (4) provides the force holding the components together and, after welding, is also used to test the leak-tightness of the weld by measuring the pressure rise in the chamber with a sensor (5). <??>The vacuum chamber (2) can be smaller than the components (8, 9) to be held, with the components resting on an interior seal (3). Alternatively, for differently shaped components, the chamber can be larger with a circumferential sealing ring.

Method for severing brittle materials by lasers with asymmetric radiation density distribution

In accordance with the method of the invention, flat workpieces of brittle material, e.g., sapphire, glass ceramic, or glass, can be severed by inducing thermomechanical stresses, particularly along severing lines of the same direction, with a laser beam having a beam spot with asymmetric radiation density distribution on the workpiece by a relative movement in different directions in that a mirror-symmetric change in radiation density is brought about exclusively by changing the method parameters.

Arrangement for storing a rail

Rotary piston compressor and process to use it

The operating process is for a rotary piston compressor (1) with rotors (10, 20) to compressed gas. The gas-dynamic impact is created in a feed chamber (4) between its inflow side (4') and outflow side (4"). The closing time from the separation of the feed chamber from the volume enlargement region (V) is measured so that the filling of the feed chamber is increased by the impact charge.

Method for controlling the body movement of a vehicle

Bereitgestellt wird ein Verfahren zur Steuerung der Karosseriebewegung eines Fahrzeugs, wobei in einem ersten Schritt eine Auswertung von im Fahrzeug oder außerhalb des Fahrzeugs erfassten Medieninformationen erfolgt, und in einem zweiten Schritt basierend auf der Auswertung ein Eingriff in das entsprechende Fahrzeugsystem erfolgt, so dass eine Längs- und/oder Quer- und/oder Vertikal- und/oder Wank- und/oder Nick- und/oder Gier-Bewegung der Karosserie des Fahrzeugs erzeugt wird. Provided is a method for controlling the body movement of a vehicle, wherein in a first step, an evaluation of captured in the vehicle or outside the vehicle media information takes place, and in a second step based on the evaluation, an intervention in the corresponding vehicle system takes place, so that a longitudinal - And / or transverse and / or vertical and / or roll and / or pitch and / or yaw movement of the body of the vehicle is generated.

Rail securing system

Process for the dyeing and printing of fibrous material with polymerized quaternary ammonium salts as auxiliary agents

Verfahren zum Färben oder Bedrucken von organischem Fasermaterial aus z.B. Polyamid, Polyester oder Polyacrylnitril, ferner auch aus Cellulose, unter Verwendung eines Färberei- oder Druckereihilfsmittels, das ein quaternäres Ammoniumsalz enthält. Als Salz wird ein Umsetzungsprodukt eines Copolymerisates aus Maleinsäureanhydrid und Aethylen, Propyien oder Styrol mit einem N,N-disubstituierten n-Alkylendiamin, ein Homopolymerisat eines Vinylpyridins oder ein quaterniertes Copolymerisat aus einem Vinylpiperidin und Styrol eingesetzt, wobei das Umsetzungsprodukt das Homo- und Copolymerisat mit z.B. Benzylchlorid quaterniert sind. Ein mit einem tertiären Monoamin quaterniertes Homopolymerisat eines Vinylbenzylchlorides kann auch als Ammoniumsalz eingesetzt werden. Die mit z.B. Direkt- oder Dispersionsfarbstoffen oder kationischen Farbstoffen gefärbten oder bedruckten Fasermaterialien weisen eine ausgezeichnete Egalität, eine gute Durchfärbung und eine gute Nassechtheit auf. Auch Mehrtoneffekte können beim stellenweisen Bedrucken mit einer Reservedruckpaste und anschliessenden Färben erzielt werden. Process for dyeing or printing organic fiber material from e.g. Polyamide, polyester or polyacrylonitrile, also made of cellulose, using a dyeing or printing aid which contains a quaternary ammonium salt. The salt used is a reaction product of a copolymer of maleic anhydride and ethylene, propylene or styrene with an N, N-disubstituted n-alkylenediamine, a homopolymer of a vinylpyridine or a quaternized copolymer of a vinylpiperidine and styrene, the reaction product including the homopolymer and copolymer e.g. Benzyl chloride are quaternized. A homopolymer of a vinylbenzyl chloride quaternized with a tertiary monoamine can also be used as the ammonium salt. The with e.g. Direct or disperse dyes or cationic dyes dyed or printed fiber materials have excellent levelness, good colouration and good wet fastness. Multi-tone effects can also be achieved when printing in places with ...

Cyclic indole-3-carboxamides, their preparation and their use as pharmaceuticals

The present invention relates to cyclic indole-3-carboxamides of the formula I, wherein A, R, R 10 , R 20 , R 30 , R 40 , n, p and q have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they inhibit the enzyme renin and modulate the activity of the renin-angiotensin system, and are useful for the treatment of diseases such as hypertension, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.

Cyclic indole-3-carboxamides, their preparation and their use as pharmaceuticals

The present invention relates to cyclic indole-3-carboxamides of the formula I, wherein A, R, R 10 , R 20 , R 30 , R 40 , n, p and q have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they inhibit the enzyme renin and modulate the activity of the renin-angiotensin system, and are useful for the treatment of diseases such as hypertension, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.

Method for the production of phenyl propyl alcohols

The invention relates to a method for the production of phenyl propyl alcohols by hydrogenation of phenyl proplyl aldehydes in the presence of a nickel catalyst containing molybdenum.

Patent DE2254052B2

Method for automatic adjustment of steel belt roller conveyor guides - using friction noise sensor, bandpass filtering and signal comparison with stored data for positioning motor control.

N- (2,2,4,4-tetrafluoro-1,3-benz-dioxanyl) ureas and process for their preparation

Use of collagen hydrolysate for improving endurance performance and for stimulating lipid catabolism

The present invention relates to the use of collagen hydrolysate for improving endurance performance by boosting mitochondrial activity. The invention further relates to the use of collagen hydrolysate for stimulating lipocatabolism, and in particular for reducing body weight, by boosting mitochondrial activity.

Indanyl-substituted benzole carbonamide, method for the production of the same, use thereof as a medicament and pharmaceutical preparations containing the same

The invention relates to compounds of formula (I), wherein R(1) to R(8) have the meanings given in the claims. Said compounds act upon the Kv1.5 potassium canal and inhibit a potassium flux, known as an 'ultra-rapidly activating delayed rectifier' in the human atrium. The compounds are therefore particularly suitable for use as novel anti-arrhythmic active ingredients, in particular, for the treatment and prophylaxis of atrial arrhythmia, e.g. atrial fibrillation (AF) or atrial flutter.

Use of collagen hydrolyzate to prepare a drug against degenerative loss of muscle mass (sarcopenia) and to improve muscle strength (divisional application 3326-2015).

LA PRESENTE INVENCIÓN SE RELACIONA CON UN HIDROLIZADO DE COLÉGENO COMO SUSTANCIA ACTIVA PARA TRATAR SARCOPENIA, COMO SUSTANCIA ACTIVA CONTRA LA PÉRDIDA DEGENERATIVA DE MASA MUSCULAR Y PARA MEJORAR LA POTENCIA MUSCULAR, COMO SUSTANCIA ACTIVA PARA REDUCIR LA PÉRDIDA DE MASA MUSCULAR RELACIONADA CON LA EDAD, Y COMO SUSTANCIA ACTIVA PARA ESTIMULAR LA CONVERSIÓN DE MASA DE GRASA CORPORAL EN MASA MUSCULAR; LA INVENCIÓN ADEMÉS SE RELACIONA CON UN MÉTODO PARA TRATAR SARCOPENIA, QUE COMPRENDE LA ADMINISTRACIÓN ORAL REPETIDA DE UN HIDROLIZADO DE COLÓGENO A UN PACIENTE. THE PRESENT INVENTION IS RELATED TO A HYDROLYZE OF COLLEGEN AS AN ACTIVE SUBSTANCE TO TREAT SARCOPENIA, AS AN ACTIVE SUBSTANCE AGAINST MUSCULAR MASS DEGENERATIVE LOSS AND TO IMPROVE MUSCLE POWER, AS AN ACTIVE SUBSTANCE TO REDUCE MUSCLE MUSCLE. AS ACTIVE SUBSTANCE TO STIMULATE THE CONVERSION OF BODY FAT MASS IN MUSCLE MASS; THE INVENTION IS ALSO RELATED TO A METHOD FOR TREATING SARCOPENIA, WHICH INCLUDES THE ORAL ADMINISTRATION REPEATED FROM A COLLAGEN HYDROLYZATE TO A PATIENT.

NOVEL TRICYCLIC COMPOUNDS, THEIR PREPARATION PROCESS, AND INTERMEDIATES THEREOF, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

PROCESS FOR THE DESTRUCTION OF TOXIC WASTE AND PLASMA-CHEMICAL REACTOR FOR THE IMPLEMENTATION OF THE PROCESS

a) Procédé pour la destruction de déchets toxiques et réacteur plasma-chimique, pour la mise en oeuvre du procédé. b) Caractérisé en ce que les déchets toxiques sont introduits directement dans un jet de plasma à vapeur d'eau, en ce qu'un temps de réaction minimum de 10**-**3s est réalisé dans un étage 14 suivant de réaction par plasma, en ce que dans un étage 15 de post-réaction, le jet de plasma est exposé, pendant un temps minimum de réaction de 10**-**2s, à l'action d'un milieu oxydant, à une température qui est au maximum de 1500 degre(s)C et un réacteur pour la mise en oeuvre du procédé caractérisé en ce qu'un anneau d'élargissement conique 6 fait suite à la bride 1 du plasmatron dans le réacteur à plasma. c) L'invention concerne un procédé pour la destruction de déchets toxiques et réacteur plasma-chimique pour la mise en oeuvre du procédé. a) Process for the destruction of toxic waste and plasma-chemical reactor, for the implementation of the process. b) Characterized in that the toxic waste is introduced directly into a water vapor plasma jet, in that a minimum reaction time of 10 ** - ** 3s is achieved in a subsequent reaction stage 14 by plasma, in that in a post-reaction stage 15, the plasma jet is exposed, for a minimum reaction time of 10 ** - ** 2s, to the action of an oxidizing medium, at a temperature which is at most 1500 degree (s) C and a reactor for the implementation of the process characterized in that a conical widening ring 6 follows the flange 1 of the plasmatron in the plasma reactor. c) The invention relates to a process for the destruction of toxic waste and a plasma-chemical reactor for carrying out the process.

Plasticized gelatin compositions, in particular for photography

Process for space-dyeing of cellulose fibers

NOVEL TRICYCLIC COMPOUNDS, THEIR PREPARATION PROCESS, AND INTERMEDIATES THEREOF, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Compounds of formula (I), wherein R1, R2, R3, R4, R5 and G are as defined in the description and the dotted lines indicate an optional second bond, as well as the acid, base and ester addition salts thereof, a method for preparing said compounds, intermediates therefor, the use of said compounds as drugs, and pharmaceutical compositions containing same, are disclosed.

Process for space-dyeing of cellulose fibers

Photochemical cross-linking of polymers

Novel imidazolidine derivatives, their preparation and their use as vla-4 antagonists

The present invention relates to novel imidazolidine derivatives of the formula (I), in which B, E, W, Y, R, R2, R3, R30, e and h have the meanings given in the claims. The compounds of the formula (I) are valuable pharmaceutical active compounds which are suitable, for example, for treating inflammatory disease, for example rheumatoid arthritis, or allergic diseases. The compounds of the formula (I) are inhibitors of the adhesion and migration of leukocytes and/or antagonists of the adhesion receptor VLA-4, which belongs to the integrin group. They are generally suitable for treating diseases which are caused by, or associated with, an undesirable degree of leukocyte adhesion and/or leukocyte migration or in which cell-cell or cell-matrix interactions, which are based on the interactions of VLA-4 receptors with their ligands, play a role. The invention furthermore relates to processes for preparing the compounds of the formula (I), to their use and topharmaceutical preparations which comprise compounds of the formula (I).

Photographic process for forming reflex copies

Antistatic photographic materials

Use of collagen hydrolysate for improving endurance performance and for stimulating lipocatabolism

The present invention relates to the use of collagen hydrolysate for improving endurance performance by boosting mitochondrial activity. The invention further relates to the use of collagen hydrolysate for stimulating lipocatabolism, and in particular for reducing body weight, by boosting mitochondrial activity.

New heterocycles on inhibitors of leukocyte adhesion and VLA-4 antagonists

Process for aftertreating dyed fibrous material made of or containing cellulose

Dyed fibrous materials made of or containing cellulose which were not bleached before dyeing are aftertreated in a combined bleaching and washing bath which can, optionally, contain as stabilizers derivatives of phosphonic or phosphorous acid, optionally as a combination with polyhydroxy compounds. The resulting materials have bright and brilliant shades. This aftertreatment makes it possible to by-pass the otherwise customary, time-consuming and expensive drying of the materials between a bleach before dyeing and the dyeing itself.

Process for the semicontinuous dyeing of tubular knitted fabrics of cellulose fibers with azo developing dyestuffs

In the dyeing of cellulose knitted fabrics in hose form, according to a two-bath procedure, with azo dyes produced on the fiber by coupling of their formation components, it was hitherto impossible on an industrial scale to forward the developing liquor in a sufficiently rapid manner into the interior of the textile hose, after impregnation of said tubular goods in a winch beck using the exhaust technique. Dyestuff development without intermediate drying was impeded by the insufficient liquor uptake of the flattened textile material that had previously been impregnated on subsequent slop-padding wet-in-wet with the developing liquor. By incorporation of an auxiliaries' combination comprising homo- or copolymers of acrylic acid amide and a wetting agent in said developing liquor, the liquor uptake thereof by the moist fiber material is increased and the penetration rate of this liquor during the coupling is incited in such a manner that textile hoses which exhibit even, well penetrated dyeings are obtained. Dyeing of tubular knitted fabrics, especially in hose form, with azo developing dyes has become safe only in accordance with this invention.

Coin and method for testing the coin

Coin (10) comprising a core (1) of a first metal, an outer ring (2) of a further metal, concentrically surrounding the core, and, between the core and the outer ring, a central ring (3), consisting of an electrically insulating material and solidly bonded to said core and outer ring, characterized in that the central ring is transmissive with respect to electromagnetic waves of a first wavelength range and less transmissive or untransmissive with respect to a second wavelength range.

Method and circuit for testing coins

Verfahren zur Prüfung von Münzen mit einer induktiv arbeitenden Sensoranordnung, die eine Primärspule und eine Sekundärspule aufweist, deren Feld von einer Münze durchquert wird, bei dem die Primärspule mit einem periodischen Sendesignal gespeist wird, das vorzugsweise Harmonische enthält und bei dem eine Auswertevorrichtung die Signale der Sekundärspule auswertet zwecks Erzeugung eines Annahme- oder Rückgabesignals, gekennzeichnet durch folgende Verfahrensschritte: Einen periodisch wiederkehrenden Abschnitt des Sendesignals wird in eine Anzahl von Schaltschritten zugeordnet Aus den Werten des Empfangssignals der einzigen Sekundärspule werden bei den jeweiligen sich mit der Frequenz des Sendesignals wiederholenden Schaltschritten Hüllkurven gebildet und Die Auswertevorrichtung bildet aus der Anzahl der zeitgleich erzeugten Hüllkurven mindestens ein Kriterium zwecks Erzeugung des Annahme- oder Rückgabesignals. Method for checking coins with an inductively operating sensor arrangement, which has a primary coil and a secondary coil, the field of which is crossed by a coin, in which the primary coil is fed with a periodic transmission signal, which preferably contains harmonics, and in which an evaluation device signals the signals Secondary coil evaluates for the purpose of generating an acceptance or return signal, characterized by the following process steps: A periodically recurring section of the transmission signal is assigned in a number of switching steps Envelopes are formed from the values of the received signal of the single secondary coil in the respective switching steps repeating with the frequency of the transmitted signal From the number of envelopes generated at the same time, the evaluation device forms at least one criterion for the purpose of generating the acceptance or return signal.

Process for the uniform dyeing of textile material webs with the aid of a uniform pre-drying

Process for the uniform pre-drying of damp textile material webs, subsequent to a continuous wet treatment operation, including measuring the moisture content remaining on the textile material, wherein, in the course of the material run, immediately behind an infrared pre-drying tunnel for the continuously fed material, several measuring positions are arranged transversely to the transport direction of the material, and measurements of the residual moisture are made by means of a contactless method, determining measuring pulses in this manner and transmitting these to the control elements of the preceding pre-dryer and within the heating power is controlled of several separately controllable heating fields, distributed across the width of the drying tunnel, in agreement with the measured values of the moisture.

Water-soluble or water-dispersible graft polymers, process for their preparation and the use thereof

Water-soluble or water-dispersible graft polymers, process for their preparation and the use thereof Abstract of the Disclosure Water-soluble or water-dispersible graft polymers which comprise a) as main chain, a polyalkylene glycol, in particular polyethylene glycol, which is esterified at the two terminal hydroxyl groups with a long chain fatty acid of 8 to 267 preferably 10 to 22, carbon atoms, and b) grafted ethylenically unsaturated monomers, pre-ferably acrylic acid or acrylamide, in the form of side chains at individual carbon atoms of the polyalkylene glycol chain. These graft polymers are particularly suitable for use as anticrease agents for dyeing, whitening, bleaching or washing textile mate-rials, e.g. textiles containing cellulosic fibres, natural or synthetic polyamide fibres, polyacrylonitrile fibres or, in particular, for dyeing or whitening cotton or polyester fibres.

Toy helicopter worked by downward air jet - is furnished with plastic sleeve inside neck of balloon to improve airflow

A toy helicopter (1) has a lifting force which comes from a toy balloon (4) whose mouth points vertically downwards (12) and whose neck passes through the overall centre of gravity of the helicopter. It has been found that the flight of the toy can take unintended forms if the neck of the balloon becomes puckered or twisted, as can easily occur. Consequently, a short length of smooth plastic tube is fitted into the neck of the balloon to hold it securely in place and guarantee the direct axial flow of the jet of air. If necessary, the new cylindrical tube is furnished with transverse partitions or radial ribs.

Method and device for separating a flat workpiece into a plurality of sections

The invention relates to a method and to a device for separating a flat workpiece (1) into a plurality of sections (7) using the technique of thermal laser beam separation (TLS). In the method, prior to the TLS step, at least one line (2) of modified material is generated along one or more predefined separating lines in the workpiece (1) by way of local material processing using a further laser, which results in a reduction of the breaking stress of the workpiece (1) along the separating lines. Said line (2) is thereby entirely, or at least sectionally, generated at a distance from the surface of the workpiece (1). By means of the method, a higher quality of the edges of the separated sections is achieved.

Imidazolidine derivatives, their preparation, and their use as antinflamatory agent

The present invention relates to novel imidazolidine derivatives of formula (I), in which A, E, Z, R1, R2, R3, R4 and R5 have the meanings indicated in the claims. The compounds of formula (I) are valuable pharmaceutical active compounds which are suitable, for example, for the treatment of inflammatory diseases, for example of rheumatoid arthritis, or of allergic diseases. The compounds of the formula (I) are inhibitors of the adhesion and migration of leukoxytes and/or antagonists of the adhesion receptor VLA-4 belonging to teh integrins group. They are generally suitable for teh treatment of diseases which are caused by an undesired extend of leukocyte adhesion and or leukocyte migration or are associated therewith or in which cell-cell or cell-matrix interactions which are based on the interactions of VLA-4 receptors with their ligands play a role. The invention furthermore relates to processes for the preparation of the compounds of formula (I), their use and pharmaceutical preparations which contain compounds of formula (I).

Coating compositions containing gelatin

METHOD FOR CONTINUOUS OPERATION OF PLASMAPYROLYSIS ACTUATORS WITH HEAVY CARBON FUELS AND COAL