Perfusion catheters and related methods

This patent document discloses perfusion catheters and related methods for treating complications related to CTO interventions or dilating a vessel occlusion while maintaining a passage through the treated vessel segment. A perfusion catheter can include a balloon formed of an inflatable tube and an elongate shaft having a lumen for providing inflation fluid to, or withdrawing inflation fluid from, the balloon. The inflatable tube can be coiled in a helical manner around a central axis into a series of windings. Adjacent windings can be stacked against and bonded to each other, and an inner surface of the series of windings, when inflated, can define the passage. The elongate shaft can be eccentrically attached to a proximal portion of the balloon and the shaft's lumen can be in fluid communication with the interior of the balloon, specifically the inflatable tube. The inflatable tube can include two different polymer tubes, one slightly smaller than the other.

Coaxial guide catheter for interventional cardiology procedures

A coaxial guide catheter to be passed through guide catheter having a first lumen, for use with interventional cardiology devices that are insertable into a branch artery that branches off from a main artery. The coaxial guide catheter is extended through the lumen of the guide catheter and beyond the distal end of the guide catheter and inserted into the branch artery. The device assists in resisting axial and shear forces exerted by an interventional cardiology device passed through the second lumen and beyond the flexible distal tip portion that would otherwise tend to dislodge the guide catheter from the branch artery.

Abdominal tissue support for femoral puncture procedures

An abdominal tissue support for supporting excess abdominal adipose tissue away from the femoral crease to facilitate the maintenance of a sterile field for femoral puncture procedures. The abdominal tissue support may generally include a waist belt, at least one support apron affixed to the waist belt and a strap arrangement. The abdominal tissue support may also include a movable support apron slidable along the length of the waist belt. The strap arrangement may be securable at a patient's shoulders or to a fixture located near the patient's head.

PERFUSION CATHETERS AND RELATED METHODS

This patent document discloses perfusion catheters and related methods for treating complications related to CTO interventions or dilating a vessel occlusion while maintaining a passage through the treated vessel segment. A perfusion catheter can include a balloon formed of an inflatable tube and an elongate shaft having a lumen for providing inflation fluid to, or withdrawing inflation fluid from, the balloon. The inflatable tube can be coiled in a helical manner around a central axis into a series of windings. Adjacent windings can be stacked against and bonded to each other, and an inner surface of the series of windings, when inflated, can define the passage. The elongate shaft can be eccentrically attached to a proximal portion of the balloon and the shaft's lumen can be in fluid communication with the interior of the balloon, specifically the inflatable tube. The inflatable tube can include two different polymer tubes, one slightly smaller than the other. 124-. (canceled)25. A method , comprising:passing a perfusion catheter, including a balloon formed of a cross-linked inner tube and a non-cross-linked outer tube and an elongate shaft having an outer surface that is attached to the balloon, into a blood vessel until the balloon is positioned near or within a treatment site;inflating the balloon by urging fluid through a lumen of the elongate shaft and into the inner tube, including inflating a series of helical windings of the balloon held together via adhesive properties of the outer tube;the balloon, upon inflation, moving from a deflated configuration to an inflated configuration at which an outer surface of the balloon engages a wall of the blood vessel or occlusive material accumulation within the wall and an inner surface of the balloon's series of helical windings defines a passage; andpassing a treatment device at least partially through the passage.26. The method of claim 25 , wherein passing the perfusion catheter into the blood vessel includes ...

System and method for freeze-drying and packaging

A system and method for protecting biological or other material from contamination through the steps of filling, freeze-drying, packaging, storing and use are disclosed. A system can include a flexible container, a membrane configured to transmit air or solvent vapor out of the flexible container, and a membrane frame supporting the membrane and engaged with at least one column member. The at least one column member can be configured to maintain the membrane and the membrane frame a spaced distance from one or more contents received within the flexible container. Upon application of a downward force, the at least one column member can assume a collapsed configuration. A method can include inserting a biological material, for example, into a flexible container, freeze-drying the biological material, moving the freeze-dried biological material to a portion of the flexible container that includes at least one port, and sealing the biological material within the portion.

Drainage or feeding catheter assembly

Catheter assemblies, kits and methods allowing for the drainage or administration of fluid or small particles are disclosed. A catheter assembly can include a shaft with a lumen, an expandable retention member, an elongate actuation member and a locking mechanism. The expandable retention member can be positioned at a shaft distal end portion and can include one or more filaments forming a plurality of drainage or administration interstices of variable or uniform size. The elongate actuation member can include an actuation member distal end, directly or indirectly engaged with the expandable retention member, and an actuation member proximal end. Movement of the actuation member proximal end relative to a proximal end of the shaft can cause the expandable retention member to change from a lower-profile configuration to a higher-profile configuration. A moved position of the elongate actuation member can be secured by rotating, sliding or otherwise manipulating the locking mechanism.

Convertible guidewire system and methods

A guidewire converter for use in intravascular procedures along with a guidewire. The guidewire converter includes an elongate tubular structure defining a lumen having an inner diameter and a first outer diameter. The inner diameter of the lumen is sized to receive the guidewire for intravascular procedures. The guidewire converter includes a locking mechanism coupled to the elongate tubular structure that has a second outer diameter that is less than or substantially equal to the first outer diameter. Operation of the locking mechanism releasably secures the elongate tubular structure to the guidewire.

GUIDEWIRE TIPPED LASER FIBER

A device for application of energy within a tubular bodily structure including an optical fiber couplable to a source of laser energy and a guidewire tip. The optical fiber has a laser emitting portion remote from the source of laser energy and a distal end. The guidewire tip is operably secured to the optical fiber and extends distally outwardly away from the distal end of the optical fiber. The guidewire tip assists in advancing the device through the tubular bodily structure.

Elongated expandable member for occluding varicose veins

Assemblies, kits, and methods for occluding a vascular vessel, such as a varicose vein, are disclosed. An assembly can include a removable inner member, a removable outer member, and an elongated expandable member positioned in a compressed form between portions of the inner and outer members. To facilitate their removal, one or both of the inner and outer members can include a handle coupled to a proximal end. The elongated expandable member can include a gelatin material or a collagen material that is configured, when wetted, to expand from a compressed first diametrical size to a second larger diametrical size within a time period of 5 minutes or less. At the second larger diametrical size, the gelatin or collagen material can occlude a vascular vessel for a period of at least 20 days without degrading.

Vascular access closure system

A sealing device for sealing punctures in blood vessel walls including a flange connected to a flexible stem having an expansion portion in it. The flexible stem is adapted to be accommodated inside a delivery tube. The delivery tube further includes a hand-hold for ease of handling. The sealing device may further include a loader and a cutter. The flange and flexible stem are preferably constructed of a biodegradable material that has a tensile strength, rigidity, memory and other physical qualities similar to medical grade silicone. The resilient transverse expansion portion expands when deployed beyond the delivery tube in the tissue tract to create a frictional interface with the interior surface of the tissue tract to resist displacement of the flexible stem from a desired location in the tissue tract. The flexible stem also includes a flange at the distal end of the flexible stem to seal the puncture when the flexible stem is deployed.

Laser fiber for endovenous therapy having a shielded distal tip

An endovenous laser fiber optic member for endovenous laser therapy of peripheral veins of the body including a heat resistant insulative tip shield covering the distal end of the laser fiber optic. The tip shield may have echogenic qualities to increase ultrasound reflectivity. The tip shield also improves deflectability of the distal end and acts as a thermal break.

SYSTEM AND METHOD FOR FREEZE-DRYING AND PACKAGING

A system and method for protecting biological or other material from contamination through the steps of filling, freeze-drying, packaging, storing and use are disclosed. A system can include a flexible container, a membrane configured to transmit air or solvent vapor out of the flexible container, and a membrane frame supporting the membrane and engaged with at least one column member. The at least one column member can be configured to maintain the membrane and the membrane frame a spaced distance from one or more contents received within the flexible container. Upon application of a downward force, the at least one column member can assume a collapsed configuration. A method can include inserting a biological material, for example, into a flexible container, freeze-drying the biological material, moving the freeze-dried biological material to a portion of the flexible container that includes at least one port, and sealing the biological material within the portion.

Medical device package

ELONGATE EXPANDABLE MEMBER FOR OCCLUDING VASCULAR VESSEL

Assemblies and methods for occluding a vascular vessel are disclosed. An assembly can include a removable outer member, an elongate expandable member, a porous cover member, and optionally, one or both of a removable inner tubular member or a seal member. The elongate expandable member and the porous cover member can be positioned in a radially compressed form between the removable outer members and, if present, the inner tubular member, with the porous cover member surrounding an outer surface of the elongate expandable member. The elongate expandable member can be configured to expand the porous cover member and occlude a vascular vessel following removal of the removable outer member. Mechanical stability and migration resistance of the elongate expandable member can be aided by the porous cover member. The seal member can be positioned at a distal end of the elongate expandable member to inhibit its expansion during vessel insertion. 1. An assembly , comprising:an elongate expandable member including a sponge- or foam-like structure; anda porous cover member surrounding an outer surface of the elongate expandable member,the elongate expandable member and the porous cover member positioned in a radially compressed form within a removable outer member, the elongate expandable member configured to expand the porous cover member and occlude a vascular vessel following removal of the removable outer member.2. The assembly of claim 1 , further comprising a seal member positioned at a distal end of the elongate expandable member.3. The assembly of claim 2 , wherein the seal member is coupled at one or more locations to the porous cover member or the removable outer member.4. The assembly of claim 2 , wherein the seal member includes one or both of a polylactide material or a polyglycolide material.5. The assembly of claim 1 , further comprising a removable inner tubular member positioned within the elongate expandable member claim 1 , the removable inner tubular member ...

CATHETER TIP

Catheters and related methods for supporting a guidewire or delivering an agent through a vessel stenosis or other tortuous anatomy are disclosed. A catheter can comprise an elongate shaft body and a polymer tip member disposed at a distal end of the shaft body. The shaft body and the tip member can include a liner, one or both of a braid member or a coil member surrounding the liner, and a polymer cover surrounding the braid member or the coil member. The tip member can further include one or more filaments extending from a position overlapping, underlapping, or abutting a distal end of the braid member or the coil member on their proximal ends to a position distal to the braid member or the coil member on their distal ends. The one or more filaments can include a plurality of filaments arranged in a series of contacting helical windings about the liner, the braid member, or the coil member. 1. A catheter , comprising:an elongate shaft body extending from a proximal end to a distal end and defining an inner lumen; anda polymer tip member disposed at the distal end of the shaft body,the shaft body and the tip member including a liner, one or both of a braid member or a coil member surrounding the liner, and a polymer cover surrounding the braid member or the coil member,the tip member further including one or more filaments extending from a position overlapping, underlapping, or abutting a distal end of the braid member or the coil member on their proximal ends to a position distal to the braid member or the coil member on their distal ends.2. The catheter of claim 1 , wherein the one or more filaments include a plurality of polymer filaments.3. The catheter of claim 2 , wherein the plurality of polymer filaments includes at least 5 polymer filaments.4. The catheter of claim 2 , wherein the plurality of polymer filaments includes at least 10 polymer filaments.5. The catheter of claim 2 , wherein the plurality of polymer filaments is helically-wound around or ...

CONVERTIBLE GUIDEWIRE SYSTEM AND METHODS

A guidewire converter for use in intravascular procedures along with a guidewire. The guidewire converter includes an elongate tubular structure defining a lumen having an inner diameter and a first outer diameter. The inner diameter of the lumen is sized to receive the guidewire for intravascular procedures. The guidewire converter includes a locking mechanism coupled to the elongate tubular structure that has a second outer diameter that is less than or substantially equal to the first outer diameter. Operation of the locking mechanism releasably secures the elongate tubular structure to the guidewire.

PERFUSION CATHETERS AND RELATED METHODS

This patent document discloses perfusion catheters and related methods for treating complications related to CTO interventions or dilating a vessel occlusion while maintaining a passage through the treated vessel segment. A perfusion catheter can include a balloon formed of an inflatable tube and an elongate shaft having a lumen for providing inflation fluid to, or withdrawing inflation fluid from, the balloon. The inflatable tube can be coiled in a helical manner around a central axis into a series of windings. Adjacent windings can be stacked against and bonded to each other, and an inner surface of the series of windings, when inflated, can define the passage. The elongate shaft can be eccentrically attached to a proximal portion of the balloon and the shaft's lumen can be in fluid communication with the interior of the balloon, specifically the inflatable tube. The inflatable tube can include two different polymer tubes, one slightly smaller than the other. 1. (canceled)2. The perfusion catheter of claim 10 , wherein the inflatable tube includes two different polymer tubes.3. The perfusion catheter of claim 2 , wherein the two different polymer tubes include an inner tube and an outer tube claim 2 , the inner tube is positioned within the outer tube.4. The perfusion catheter of claim 5 , wherein the polymer of the inner tube has a higher melting temperature than the polymer of the outer tube.5. A perfusion catheter claim 5 , comprising:an inflatable balloon including concentric inner and outer tubes. a polymer of the inner tube is cross-linked and a polymer of the outer tube is non-cross-linked,the inner and outer tubes are coiled in a helical manner around a central axis into a series of windings with adjacent windings stacked against and bonded to each other, an inner surface of the series of windings, when inflated, defines a passage through the balloon; andan elongate shaft extending from a proximal portion to a distal portion and including a lumen for ...

SYSTEM AND METHOD FOR FREEZE-DRYING AND PACKAGING

A system and method for protecting biological or other material from contamination through the steps of filling, freeze-drying, packaging, storing and use are disclosed. A system can include a flexible container, a membrane configured to transmit air or solvent vapor out of the flexible container, and a membrane frame supporting the membrane and engaged with at least one column member. The at least one column member can be configured to maintain the membrane and the membrane frame a spaced distance from one or more contents received within the flexible container. Upon application of a downward force, the at least one column member can assume a collapsed configuration. A method can include inserting a biological material, for example, into a flexible container, freeze-drying the biological material, moving the freeze-dried biological material to a portion of the flexible container that includes at least one port, and sealing the biological material within the portion.

Hemostatic wound dressing

A hemostatic dressing for applying a hemostatic material such as lyophilized thrombin to a wound. The wound dressing includes an impermeable backing material and a sealing member to provide a seal against the skin. The wound dressing enables the application of pressure in order to seal the sealing member against the patient's skin to the wound without the need for attendance by a health care professional. The seal may be applied by a compressive band or by application of a pressure sensitive adhesive. The wound dressing creates a sealed localized procoagulation environment to facilitate the formation of a clot initiated by the presence of substantial quantities of externally supplied lyophilized thrombin or another dry coagulant.

Coaxial guide catheter for interventional cardiology procedures

A coaxial guide catheter to be passed through guide catheter having a first lumen, for use with interventional cardiology devices that are insertable into a branch artery that branches off from a main artery. The coaxial guide catheter is extended through the lumen of the guide catheter and beyond the distal end of the guide catheter and inserted into the branch artery. The device assists in resisting axial and shear forces exerted by an interventional cardiology device passed through the second lumen and beyond the flexible distal tip portion that would otherwise tend to dislodge the guide catheter from the branch artery.

METAL VASCULAR APERTURE CLOSURE DEVICE

A closure device to be inserted at least partially through a blood vessel wall aperture in a blood vessel wall, having at least two metal petals that can be inserted through the blood vessel wall aperture and into the lumen of the blood vessel. The petals are structured to prevent withdrawal through the blood vessel wall aperture when the length of the petal is generally aligned with the blood vessel wall. The metal petals have alignment features that tend to urge them into alignment relative to each other. The closure device includes a metal expansion member that is alterable from an unexpanded state to an expanded state. A bioabsorbable tensioning member interconnects the petals and the metal expansion member and is securable to the metal expansion member.

System and method for freeze-drying and packaging

A system and method for protecting biological or other material from contamination through the steps of filling, freeze-drying, packaging, storing and use are disclosed. A system can include a flexible container, a membrane configured to transmit air or solvent vapor out of the flexible container, and a membrane frame supporting the membrane and engaged with at least one column member. The at least one column member can be configured to maintain the membrane and the membrane frame a spaced distance from one or more contents received within the flexible container. Upon application of a downward force, the at least one column member can assume a collapsed configuration. A method can include inserting a biological material, for example, into a flexible container, freeze-drying the biological material, moving the freeze-dried biological material to a portion of the flexible container that includes at least one port, and sealing the biological material within the portion.

Catheter tip

Catheters and related methods for supporting a guidewire or delivering an agent through a vessel stenosis or other tortuous anatomy are disclosed. A catheter can comprise an elongate shaft body and a polymer tip member disposed at a distal end of the shaft body. The shaft body and the tip member can include a liner, one or both of a braid member or a coil member surrounding the liner, and a polymer cover surrounding the braid member or the coil member. The tip member can further include one or more filaments extending from a position overlapping, underlapping, or abutting a distal end of the braid member or the coil member on their proximal ends to a position distal to the braid member or the coil member on their distal ends. The one or more filaments can include a plurality of filaments arranged in a series of contacting helical windings about the liner, the braid member, or the coil member.

Small diameter intravascular catheter with screw tip and limited torsional displacement

A catheter to be passed over a guidewire, including a screw portion with a cylindrical hollow shaft and a helical thread portion extending outwardly from the hollow shaft. The screw portion is secured coaxially to a tubular portion formed from a substantially rigid material. The tubular portion has, along a portion of its length, at least two slits having a pattern geometry that limits torsional displacement. The catheter also includes a hub having a lumen joined substantially coaxially to the tubular portion.

SYSTEM AND METHOD FOR FREEZE-DRYING AND PACKAGING

A system and method for protecting biological or other material from contamination through the steps of filling, freeze-drying, packaging, storing and use are disclosed. A system can include a flexible container, a membrane configured to transmit air or solvent vapor out of the flexible container, and a membrane frame supporting the membrane and engaged with at least one column member. The at least one column member can be configured to maintain the membrane and the membrane frame a spaced distance from one or more contents received within the flexible container. Upon application of a downward force, the at least one column member can assume a collapsed configuration. A method can include inserting a biological material, for example, into a flexible container, freeze-drying the biological material, moving the freeze-dried biological material to a portion of the flexible container that includes at least one port, and sealing the biological material within the portion. 1. A system , comprising:a flexible container defined by a height of a first dimension and a width of a second dimension,the height having an intermediate location separating the flexible container into a first portion and a second portion;a membrane, located within the first portion, configured to transmit air or solvent vapor out of, and resist liquid or contaminant passage into, the flexible container; anda membrane frame, coupled to both the membrane around its perimeter and a portion of the flexible container and engaged with at least one column member,the at least one column member configured to support the membrane and the membrane frame a spaced distance from one or more contents receivable within the flexible container.2. The system of claim 1 , wherein the at least one column member includes a plurality of column members configured to change shape or position claim 1 , relative to the membrane frame claim 1 , upon application of a downward force to the membrane frame.3. The system of claim 2 , ...

VASCULAR INTRODUCER INCLUDING EXPANDABLE PASSAGE MEMBER

Vascular introducer systems, kits, and methods providing or creating access to vessels, such as radial or femoral arteries, are disclosed. A vascular introducer system includes a removable inner tubular member, a removable outer tubular, tear-away member, and an expandable passage member positioned between the inner and outer tubular members. The removable inner tubular member and the removable outer tubular, tear-away member help protect and maintain a contracted configuration of the expandable passage member when the introducer system is advanced into a vessel. The expandable passage member includes an inner surface configured to receive an elongate treatment device, for example, following removal of the inner and outer tubular members. In some examples, the expandable passage member includes one or more kink-resistant members extending along a portion of the passage member. In various examples, the expandable passage member includes a wall thickness sufficient to protect vessel surfaces, while preserving vessel access size. 1. A vascular introducer system , comprising:a removable inner tubular member;a removable outer tubular, tear-away member; andan expandable passage member positioned between the inner tubular member and the outer tubular, tear-away member, the expandable passage member configured to sufficiently allow for controlled inelastic radial expansion upon application of a radial force thereto,wherein the expandable passage member includes an inner surface configured to receive an elongate treatment device following removal of both the inner and the outer tubular members.2. The vascular introducer system of claim 1 , wherein the expandable passage member includes a folded claim 1 , wrapped claim 1 , or rolled polymer member extending about a circumference of the inner tubular member.3. The vascular introducer system of claim 1 , wherein the expandable passage member includes a wall thickness of about 0.001 inches to about 0.002 inches.4. The vascular ...

Laser fiber for endovenous therapy having a shielded distal tip

An endovenous laser fiber optic member for endovenous laser therapy of peripheral veins of the body including a flexible heat resistant tip shield covering the distal end of the laser fiber optic. The tip shield has an irregular surface to increase ultrasound reflectivity. The tip shield also improves deflectability of the distal end and acts as a heat sink and heat energy dissipater.

STENOTIC REGION SCORING ASSEMBLY AND METHOD

Assemblies and methods for scoring a stenotic region within a vessel of a patient are disclosed. An assembly can comprise a scoring member and a deployment member. The scoring member can include an elongate push structure and a tubular, self-expanding scaffold. The elongate push structure can be positioned proximal of the self-expanding scaffold and, at its distal end portion, eccentrically coupled with a proximal end portion of the self-expanding scaffold. The deployment member can be removably positioned within a central lumen of the self-expanding scaffold and detachably engageable with a portion of the self-expanding scaffold. The self-expanding scaffold can be movable between a downsized configuration, when receiving axial tension from the deployment member, and an expanded configuration, in the absence of axial tension. The assembly can further comprise means for detachably engaging the deployment member and the self-expanding scaffold and means for detachably engaging the deployment member and the elongate push structure. 1. An assembly for scoring a stenotic region within a vessel , comprising:a scoring member including an elongate push structure and a tubular, self-expanding scaffold, the elongate push structure positioned proximal of the self-expanding scaffold and, at its distal end portion, eccentrically coupled with a proximal end portion of the self-expanding scaffold; anda deployment member positionable within a central lumen of the self-expanding scaffold and detachably engageable with a portion of the self-expanding scaffold,the self-expanding scaffold movable between a downsized configuration, facilitating insertion of the scoring member into the vessel, when receiving axial tension from the deployment member, and an expanded configuration, facilitating contact with the stenotic region, in the absence of axial tension.2. The assembly of claim 1 , wherein the proximal end portion of the self-expanding scaffold includes an angled opening sized and ...

Abdominal tissue support for femoral puncture procedures

An abdominal tissue support for supporting excess abdominal adipose tissue away from the femoral crease to facilitate the maintenance of a sterile field for femoral puncture procedures. The abdominal tissue support may generally include a waist belt, at least one support apron affixed to the waist belt and a strap arrangement. The abdominal tissue support may also include a movable support apron slidable along the length of the waist belt. The strap arrangement may be securable at a patient's shoulders or to a fixture located near the patient's head.

ELONGATED EXPANDABLE MEMBER FOR OCCLUDING VARICOSE VEINS

Assemblies, kits, and methods for occluding a vascular vessel, such as a varicose vein, are disclosed. An assembly can include a removable inner member, a removable outer member, and an elongated expandable member positioned in a compressed form between portions of the inner and outer members. To facilitate their removal, one or both of the inner and outer members can include a handle coupled to a proximal end. The elongated expandable member can include a gelatin material or a collagen material that is configured, when wetted, to expand from a compressed first diametrical size to a second larger diametrical size within a time period of 5 minutes or less. At the second larger diametrical size, the gelatin or collagen material can occlude a vascular vessel for a period of at least 20 days without degrading. 115-. (canceled)16. A method , comprising:inserting an elongated expandable member, including a gelatin or collagen material and covered by an outer member, into a vascular vessel;longitudinally positioning the elongated expandable member in alignment with a portion of the natural flow duct of the vascular vessel; andremoving the outer member, including allowing the elongated expandable member to expand from a compressed first size to a second larger size and occlude the duct of the vascular vessel.17. The method of claim 24 , further comprising removing the inner tubular member at a time after the elongated expandable member expands from the first size.18. The method of claim 24 , wherein inserting the elongated expandable member into the vascular vessel includes guiding the lumen of the inner tubular member over a guide wire.19. The method of claim 16 , wherein inserting the elongated expandable member into the vascular vessel includes inserting an elongated expandable member having a length of at least 10 centimeters into a great saphenous vein or a lesser saphenous vein.20. The method of claim 16 , wherein inserting the elongated expandable member into the ...

Stenotic region scoring assembly and method

Assemblies and methods for scoring a stenotic region within a vessel of a patient are disclosed. An assembly can comprise a scoring member and a deployment member. The scoring member can include an elongate push structure and a tubular, self-expanding scaffold. The elongate push structure can be positioned proximal of the self-expanding scaffold and, at its distal end portion, eccentrically coupled with a proximal end portion of the self-expanding scaffold. The deployment member can be removably positioned within a central lumen of the self-expanding scaffold and detachably engageable with a portion of the self-expanding scaffold. The self-expanding scaffold can be movable between a downsized configuration, when receiving axial tension from the deployment member, and an expanded configuration, in the absence of axial tension. The assembly can further comprise means for detachably engaging the deployment member and the self-expanding scaffold and means for detachably engaging the deployment ...

Elongated expandable member for occluding varicose veins

Assemblies, kits, and methods for occluding a vascular vessel, such as a varicose vein, are disclosed. An assembly can include a removable inner member, a removable outer member, and an elongated expandable member positioned in a compressed form between portions of the inner and outer members. To facilitate their removal, one or both of the inner and outer members can include a handle coupled to a proximal end. The elongated expandable member can include a gelatin material or a collagen material that is configured, when wetted, to expand from a compressed first diametrical size to a second larger diametrical size within a time period of 5 minutes or less. At the second larger diametrical size, the gelatin or collagen material can occlude a vascular vessel for a period of at least 20 days without degrading.

FLUID DELIVERY OR REMOVAL SYSTEM

Fluid delivery or removal systems and methods for use during a medical procedure are disclosed. A system can include a base member, a receptacle configured to be received by a chamber of the base member, and a pressure sensor. The base member can include a piston having the pressure sensor positioned at or near its tip, a powered actuator for imparting motive forces to the piston, and a rechargeable power supply to energize the actuator. The receptacle is configured to contain a volume of fluid partially retained by a seal member. A surface of the seal member opposite the fluid can include a cavity to receive and engage the piston's tip when the receptacle is placed in the chamber. Based on a user-defined parameter input (e.g., a desired pressure set point) received by the system, the piston can be driven in an axial direction by the powered actuator, thereby urging an amount of fluid through a distal opening in the receptacle. 1. A fluid delivery or removal system , comprising:a receptacle configured to contain a volume of fluid, the receptacle having a first end having an opening of a first diameter and a second end having an opening of a second diameter that is smaller than the first diameter;a seal member positioned near the first end and engaged with an interior surface of the receptacle along its perimeter;a base member including a piston and a powered actuator for imparting motive forces to the piston, the piston having a tip engageable with the seal member; anda pressure sensor incorporated within, or positioned on, a surface of the tip and configured to measure a load exerted thereon by the fluid.2. The system of claim 1 , further comprising a display configured to present an indication representative of the load exerted by the fluid.3. The system of claim 1 , further comprising one or more input receiving members claim 1 , accessible from outside the base member and in electrical communication with the powered actuator claim 1 , for setting a desired ...

Guidewire tipped laser fiber

A device for application of energy within a tubular bodily structure including an optical fiber couplable to a source of laser energy and a guidewire tip. The optical fiber has a laser emitting portion remote from the source of laser energy and a distal end. The guidewire tip is operably secured to the optical fiber and extends distally outwardly away from the distal end of the optical fiber. The guidewire tip assists in advancing the device through the tubular bodily structure.

Metal vascular aperture closure device

A closure device to be inserted at least partially through a blood vessel wall aperture in a blood vessel wall, having at least two metal petals that can be inserted through the blood vessel wall aperture and into the lumen of the blood vessel. The petals are structured to prevent withdrawal through the blood vessel wall aperture when the length of the petal is generally aligned with the blood vessel wall. The metal petals have alignment features that tend to urge them into alignment relative to each other. The closure device includes a metal expansion member that is alterable from an unexpanded state to an expanded state. A bioabsorbable tensioning member interconnects the petals and the metal expansion member and is securable to the metal expansion member.

Coaxial Guide Catheter for Interventional Cardiology Procedures

A coaxial guide catheter to be passed through guide catheter having a first lumen, for use with interventional cardiology devices that are insertable into a branch artery that branches off from a main artery. The coaxial guide catheter is extended through the lumen of the guide catheter and beyond the distal end of the guide catheter and inserted into the branch artery. The device assists in resisting axial and shear forces exerted by an interventional cardiology device passed through the second lumen and beyond the flexible distal tip portion that would otherwise tend to dislodge the guide catheter from the branch artery.

Coaxial guide catheter for interventional cardiology procedures

A coaxial guide catheter to be passed through guide catheter having a first lumen, for use with interventional cardiology devices that are insertable into a branch artery that branches off from a main artery. The coaxial guide catheter is extended through the lumen of the guide catheter and beyond the distal end of the guide catheter and inserted into the branch artery. The device assists in resisting axial and shear forces exerted by an interventional cardiology device passed through the second lumen and beyond the flexible distal tip portion that would otherwise tend to dislodge the guide catheter from the branch artery.

Metal vascular aperture closure device

A closure device to be inserted at least partially through a blood vessel wall aperture in a blood vessel wall. The closure device includes at least two parts, an internal part and an external part. The internal part is adapted to be extended at least partially through the blood vessel wall aperture and into the lumen to at least partially block the blood vessel wall aperture. Each of the internal part and the external part consists essentially of a metal that biodegrades within a living being in a period of time that permits biological repair of the blood vessel wall in and around the blood vessel aperture.

Vascular access closure system

A sealing device for sealing punctures in blood vessel walls including a flange connected to a flexible stem having an expansion portion in it. The flexible stem is adapted to be accommodated inside a delivery tube. The delivery tube further includes a hand-hold for ease of handling. The sealing device may further include a loader and a cutter. The flange and flexible stem are preferably constructed of a biodegradable material that has a tensile strength, rigidity, memory and other physical qualities similar to medical grade silicone. The resilient transverse expansion portion expands when deployed beyond the delivery tube in the tissue tract to create a frictional interface with the interior surface of the tissue tract to resist displacement of the flexible stem from a desired location in the tissue tract. The flexible stem also includes a flange at the distal end of the flexible stem to seal the puncture when the flexible stem is deployed.

VASCULAR INTRODUCER INCLUDING EXPANDABLE PASSAGE MEMBER

Vascular introducer systems, kits, and methods providing or creating access to vessels, such as radial or femoral arteries, are disclosed. A vascular introducer system includes a removable inner tubular member, a removable outer tubular, tear-away member, and an expandable passage member positioned between the inner and outer tubular members. The removable inner tubular member and the removable outer tubular, tear-away member help protect and maintain a contracted configuration of the expandable passage member when the introducer system is advanced into a vessel. The expandable passage member includes an inner surface configured to receive an elongate treatment device, for example, following removal of the inner and outer tubular members. In some examples, the expandable passage member includes one or more kink-resistant members extending along a portion of the passage member. In various examples, the expandable passage member includes a wall thickness sufficient to protect vessel surfaces, while preserving vessel access size. 1. (canceled)2. A method , comprising:inserting at least a distal end portion of each of an inner tubular member, an expandable passage member, and an outer tubular member into a vessel, including maintaining (i) a proximate positioning of a proximal end of the expandable passage member relative to a proximal end of the outer tubular member and (ii) a common axis arrangement of each of the members from their respective proximal end to their respective distal end;removing the outer tubular member;removing the inner tubular member; andfollowing removal of the outer tubular member and the inner tubular member, radially expanding an inner surface of the expandable passage member from a first diametrical size to a larger second diametrical size, including introducing a radial force against the inner surface sufficient to inelastically expand the expandable passage member.3. The method of claim 2 , wherein inserting the inner tubular member claim 2 ...

Vascular dilator systems, kits, and methods

Vascular dilator systems, kits, and methods allowing for sheathless introduction of a treatment device into a body vessel or body cavity are disclosed. A vascular dilator system can include a dilator assembly, including a tubular shaft and a deformable member, and optionally, the treatment device. The deformable member can include a non-biodegradable material and can have a diameter at a proximal end portion that is greater than a diameter at a distal end portion. The distal end portion of the deformable member can be coupled to an outer surface of the tubular shaft, at or near a shaft distal end portion. The proximal end portion of the deformable member can include a diameter configured to receive or stretch around a distal end portion of the treatment device. In use, the deformable member can provide a tapered bridge between the outer surface of the tubular shaft and an outer surface of the treatment device.

COAXIAL GUIDE CATHETER FOR INTERVENTIONAL CARDIOLOGY PROCEDURES

A coaxial guide catheter to be passed through guide catheter having a first lumen, for use with interventional cardiology devices that are insertable into a branch artery that branches off from a main artery. The coaxial guide catheter is extended through the lumen of the guide catheter and beyond the distal end of the guide catheter and inserted into the branch artery. The device assists in resisting axial and shear forces exerted by an interventional cardiology device passed through the second lumen and beyond the flexible distal tip portion that would otherwise tend to dislodge the guide catheter from the branch artery.

METAL VASCULAR APERTURE CLOSURE DEVICE

A closure device to be inserted at least partially through a blood vessel wall aperture in a blood vessel wall. The closure device includes at least two parts, an internal part and an external part. The internal part is adapted to be extended at least partially through the blood vessel wall aperture and into the lumen to at least partially block the blood vessel wall aperture. Each of the internal part and the external part consists essentially of a metal that biodegrades within a living being in a period of time that permits biological repair of the blood vessel wall in and around the blood vessel aperture.

System and method for freeze-drying and packaging

A system and method for protecting biological or other material from contamination through the steps of filling, freeze-drying, packaging, storing and use are disclosed. A system can include a flexible container, a membrane configured to transmit air or solvent vapor out of the flexible container, and a membrane frame supporting the membrane and engaged with at least one column member. The at least one column member can be configured to maintain the membrane and the membrane frame a spaced distance from one or more contents received within the flexible container. Upon application of a downward force, the at least one column member can assume a collapsed configuration. A method can include inserting a biological material, for example, into a flexible container, freeze-drying the biological material, moving the freeze-dried biological material to a portion of the flexible container that includes at least one port, and sealing the biological material within the portion.

Small diameter intravascular catheter with screw tip and limited torsional displacement

A catheter to be passed over a guidewire, including a screw portion with a cylindrical hollow shaft and a helical thread portion extending outwardly from the hollow shaft. The screw portion is secured coaxially to a tubular portion formed from a substantially rigid material. The tubular portion has, along a portion of its length, at least two slits having a pattern geometry that limits torsional displacement. The catheter also includes a hub having a lumen joined substantially coaxially to the tubular portion.

SYSTEM AND METHOD FOR FREEZE-DRYING AND PACKAGING

A system and method for protecting biological or other material from contamination through the steps of filling, freeze-drying, packaging, storing and use are disclosed. A system can include a flexible container, a membrane configured to transmit air or solvent vapor out of the flexible container, and a membrane frame supporting the membrane and engaged with at least one column member. The at least one column member can be configured to maintain the membrane and the membrane frame a spaced distance from one or more contents received within the flexible container. Upon application of a downward force, the at least one column member can assume a collapsed configuration. A method can include inserting a biological material, for example, into a flexible container, freeze-drying the biological material, moving the freeze-dried biological material to a portion of the flexible container that includes at least one port, and sealing the biological material within the portion. 1. A method , comprising:inserting a biological material into a flexible container in which a first container side includes a gas-permeable membrane;freeze-drying the biological material in the flexible container, including allowing air or solvent vapor to escape the flexible container through the membrane;moving the freeze-dried biological material to a portion of the flexible container spaced from the membrane; andsealing the biological material within the portion of the flexible container spaced from the membrane.2. The method of claim 1 , further comprising preventing the membrane from contacting the biological material.3. The method of claim 2 , wherein preventing the membrane from contacting the biological material includes supporting the membrane at a spaced distance from a second container side using a membrane frame and at least one column member.4. The method of claim 3 , further comprising claim 3 , prior to sealing the biological material within the portion of the flexible container spaced ...

Coaxial guide catheter for interventional cardiology procedures

A coaxial guide catheter to be passed through guide catheter having a first lumen, for use with interventional cardiology devices that are insertable into a branch artery that branches off from a main artery. The coaxial guide catheter is extended through the lumen of the guide catheter and beyond the distal end of the guide catheter and inserted into the branch artery. The device assists in resisting axial and shear forces exerted by an interventional cardiology device passed through the second lumen and beyond the flexible distal tip portion that would otherwise tend to dislodge the guide catheter from the branch artery.

Path Creation Through Occlusion

This patent document discloses assemblies, alignment devices and methods for creating a bi-directional path through an occlusion. An alignment device can include a positioning member and a tubular member. The tubular member can be coupled with a distal end portion of the positioning member and can include proximal and distal progressive size-changing shapes separated by a narrow neck passageway. An assembly can include the alignment device, a guide catheter having a lumen in which the alignment device is at least partially positioned, a guidewire, and a specialty catheter for supporting the guidewire. The alignment device and the guide catheter can be advanced in an antegrade direction to a proximal end of the occlusion, and the guidewire and the specialty catheter can be advanced in a retrograde direction to a distal end of the occlusion. The guidewire and the specialty catheter can be manipulated through the occlusion and into the distal end of the tubular member. 1. An assembly for creating a bi-directional path through an occlusion , comprising:an alignment device including a positioning member and a tubular member defining a passageway,a distal end portion of the positioning member coupled with the tubular member,a proximal end portion and a distal end portion of the tubular member including a configuration having a progressive size-changing shape, each size-changing shape having an opening with a diameter greater than a diameter of an intermediate portion of the tubular member.2. The assembly of claim 1 , wherein the positioning member is eccentrically coupled with the tubular member.3. The assembly of claim 1 , wherein the proximal end portion of the tubular member includes an angled side opening.4. The assembly of claim 1 , wherein the positioning member includes an elongated hypotube claim 1 , ribbon claim 1 , or wire.5. The assembly of claim 1 , wherein an intermediate portion or the distal end portion of the positioning member includes an arcuate cross- ...

VASCULAR DILATOR SYSTEMS, KITS, AND METHODS

Vascular dilator systems, kits, and methods allowing for sheathless introduction of a treatment device into a body vessel or body cavity are disclosed. A vascular dilator system can include a dilator assembly, including a tubular shaft and a deformable member, and optionally, the treatment device. The deformable member can include a non-biodegradable material and can have a diameter at a proximal end portion that is greater than a diameter at a distal end portion. The distal end portion of the deformable member can be coupled to an outer surface of the tubular shaft, at or near a shaft distal end portion. The proximal end portion of the deformable member can include a diameter configured to receive or stretch around a distal end portion of the treatment device. In use, the deformable member can provide a tapered bridge between the outer surface of the tubular shaft and an outer surface of the treatment device.

Perfusion catheters and related methods

This patent document discloses perfusion catheters and related methods for treating complications related to CTO interventions or dilating a vessel occlusion while maintaining a passage through the treated vessel segment. A perfusion catheter can include a balloon formed of an inflatable tube and an elongate shaft having a lumen for providing inflation fluid to, or withdrawing inflation fluid from, the balloon. The inflatable tube can be coiled in a helical manner around a central axis into a series of windings. Adjacent windings can be stacked against and bonded to each other, and an inner surface of the series of windings, when inflated, can define the passage. The elongate shaft can be eccentrically attached to a proximal portion of the balloon and the shaft's lumen can be in fluid communication with the interior of the balloon, specifically the inflatable tube. The inflatable tube can include two different polymer tubes, one slightly smaller than the other.

ELONGATED EXPANDABLE MEMBER FOR OCCLUDING VARICOSE VEINS

Assemblies, kits, and methods for occluding a vascular vessel, such as a varicose vein, are disclosed. An assembly can include a removable inner member, a removable outer member, and an elongated expandable member positioned in a compressed form between portions of the inner and outer members. To facilitate their removal, one or both of the inner and outer members can include a handle coupled to a proximal end. The elongated expandable member can include a gelatin material or a collagen material that is configured, when wetted, to expand from a compressed first diametrical size to a second larger diametrical size within a time period of 5 minutes or less. At the second larger diametrical size, the gelatin or collagen material can occlude a vascular vessel for a period of at least 20 days without degrading. 1. An assembly at least partially positionable within a vascular vessel , comprising:a removable inner member, the inner member including a handle coupled to a proximal end portion;a removable outer member, the outer member including an impermeable material; andan elongated expandable member positioned in a compressed form within the outer member and adjacent to portions of the inner member, the elongated expandable member configured to expand and occlude the vascular vessel following in situ separation and removal of the outer member.2. The assembly of claim 1 , wherein the elongated expandable member is positioned in a compressed form between portions of the inner member and the outer member.3. The assembly of claim 1 , wherein the elongated expandable member includes a gelatin material or a collagen material.4. The assembly of claim 3 , wherein the gelatin or collagen material includes a degree of vapor cross-linking characterized by Lysine residuals of 1.5% or less.5. The assembly of claim 4 , wherein the degree of cross-linking is configured to prevent the gelatin or collagen material from degrading for a period of at least 20 days.6. The assembly of claim 1 ...

System and method for freeze-drying and packaging

A system and method for protecting biological or other material from contamination through the steps of filling, freeze-drying, packaging, storing and use are disclosed. A system can include a flexible container, a membrane configured to transmit air or solvent vapor out of the flexible container, and a membrane frame supporting the membrane and engaged with at least one column member. The at least one column member can be configured to maintain the membrane and the membrane frame a spaced distance from one or more contents received within the flexible container. Upon application of a downward force, the at least one column member can assume a collapsed configuration. A method can include inserting a biological material, for example, into a flexible container, freeze-drying the biological material, moving the freeze-dried biological material to a portion of the flexible container that includes at least one port, and sealing the biological material within the portion.

Guidewires and Methods for Percutaneous Occlusion Crossing

Guidewires and related methods for percutaneous crossing of an occlusion in a blood vessel are disclosed. A guidewire can include a core member and a jacket member. The core member can extend from a proximal end portion to a distal end portion, with the distal end portion including a first segment, a more distal second segment and a more proximal third segment. The first segment can be configured to encourage prolapse by way of a short taper or a diameter-reduced portion. The jacket member can surround at least the distal end portion of the core member. A method can include advancing a distal end portion of the guidewire through the natural lumen of a blood vessel to a location near an occlusion. A longitudinal pushing force can be applied to a proximal end portion of the guidewire, thereby causing a first segment of the distal end portion to prolapse. 1. A guidewire , comprising:a core member extending from a proximal end portion to a distal end portion, the distal end portion including a first segment, a more distal second segment and a more proximal third segment,the first segment configured to encourage prolapse; anda jacket member surrounding at least the distal end portion of the core member.2. The guidewire of claim 1 , wherein the first segment has a length in a range of about 0.05 cm to about 1 cm claim 1 , inclusive.3. The guidewire of claim 2 , wherein the length of the first segment is in a range of about 0.05 cm to about 0.5 cm claim 2 , inclusive.4. The guidewire of claim 2 , wherein a diameter of a proximal end of the second segment is at least 40 percent less than a diameter of a distal end of the third segment claim 2 , andwherein the diameter reduction takes place within the first segment.5. The guidewire of claim 1 , wherein longitudinal stiffness of the second segment is greater than longitudinal stiffness of the first segment.6. The guidewire of claim 1 , wherein the outer surface of the first segment includes a parabolic or near-parabolic shape ...

CATHETER

Catheters and methods for supporting a guidewire or delivering a radiopaque, diagnostic or therapeutic agent through a vessel stenosis or other tortuous anatomy are disclosed. A catheter can comprise an elongate shaft body and a tip member disposed at a distal end of the shaft body. The shaft body can extend from a proximal end to the distal end and can define an inner lumen. The shaft body can include a liner, a braid member surrounding the liner, a multi-layer coil surrounding the braid member, and a polymer cover surrounding the multi-layer coil. The multi-layer coil can include first and second coil layers wound in opposing directions. An outer surface portion of the polymer cover can include one or more helical threads. The tip member can be made from a metal or a polymer and can also include one or more helical threads around its outer surface. 1. A catheter , comprising:an elongate shaft body extending from a proximal end to a distal end and defining an inner lumen, the shaft body including a liner, a braid member and a coil member surrounding at least a portion of the liner, and an outer polymer cover; anda tip member disposed at the distal end of the shaft body,wherein a distal end of the liner and the coil member extend beyond the distal end of the shaft body and into a proximal end of the tip member.2. The catheter of claim 1 , wherein the coil member includes one or more helically wound elongate strands composed of a same material composition at each of the proximal end of the shaft body claim 1 , the distal end of the shaft body claim 1 , and the proximal end of the tip member.3. The catheter of claim 1 , wherein the coil member includes one or more helically wound elongate strands having a cross-sectional size that is the same at each of the proximal end of the shaft body claim 1 , the distal end of the shaft body claim 1 , and the proximal end of the tip member.4. The catheter of claim 1 , wherein the coil member incudes multiple elongate strands ...

Guidewire Capture

Assemblies and methods for capturing a guidewire advanced through a blood vessel in a retrograde direction are disclosed. An assembly can include a constraining catheter and a capture catheter. The constraining catheter can include a first longitudinal member and a tubular member; the tubular member can be eccentrically coupled with a distal end portion of the first longitudinal member. The capture catheter can include a second longitudinal member and a funnel member; the funnel member can be eccentrically coupled with a distal end portion of the second longitudinal member. The funnel member can be moved between a collapsed configuration and an expanded configuration through relative movement between the first and second longitudinal members. In the collapsed configuration, at least a portion of the funnel member is disposed within a lumen of the tubular member. In the expanded configuration, the portion of the funnel member projects from an end of the tubular member. 1. An assembly for capturing a guidewire advanced through a blood vessel , comprising:a constraining catheter including a first longitudinal member and a tubular member, the tubular member coupled with a distal end portion of the first longitudinal member and defining a lumen; anda capture catheter including a second longitudinal member and a funnel member, the funnel member coupled with a distal end portion of the second longitudinal member and, in a distal-to-proximal direction, defining a narrowing passageway,wherein the funnel member is movable between a collapsed configuration, where at least a portion of the funnel member is disposed within the lumen of the tubular member, and an expanded configuration for capturing the guidewire, where the portion of the funnel member projects from an end of the tubular member.2. The assembly of claim 1 , wherein the tubular member is eccentrically coupled with the distal end portion of the first longitudinal member.3. The assembly of claim 1 , wherein the ...

PERFUSION CATHETERS AND RELATED METHODS

Perfusion catheters and related methods for treating complications related to CTO interventions or dilating a vessel occlusion while maintaining a passage through the treated vessel segment are disclosed. A perfusion catheter can include a balloon formed of an inflatable tube and an elongate shaft having a lumen for providing inflation fluid to, or withdrawing inflation fluid from, the balloon. The inflatable tube can be coiled in a helical manner around a central axis into a series of windings. Adjacent windings can be stacked against and bonded to each other, and an inner surface of the series of windings, when inflated, can define the passage. The elongate shaft can be eccentrically attached to the balloon and the shaft's lumen can be in fluid communication with the interior of the balloon, specifically the inflatable tube. The inflatable tube can include two different polymer tubes, one slightly smaller than the other. 1. A perfusion catheter , comprising:a balloon including an inflatable tube coiled in a helical manner around a central axis into a series of windings with adjacent windings stacked against and bonded to each other, an inner surface of the series of windings, when inflated, defining a passage through the center of the helix for delivery of a medical device or maintaining blood flow;an elongate shaft extending proximal of the balloon and eccentrically positioned relative to the passage; anda guidewire support tube having a length less than a combined length of the balloon and the elongate shaft and having a guidewire lumen therethrough, the guidewire support tube extending through the passage and non-coaxial with the elongate shaft.2. The perfusion catheter of claim 1 , wherein the inflatable tube of the balloon includes two different polymer tubes claim 1 , an inner tube positioned within an outer tube claim 1 , that are coextruded.3. The perfusion catheter of claim 2 , wherein the inner tube is formed from a polymer having a radial stiffness to ...

Perfusion catheters and related methods

This patent document discloses perfusion catheters and related methods for treating complications related to CTO interventions or dilating a vessel occlusion while maintaining a passage through the treated vessel segment. A perfusion catheter can include a balloon formed of an inflatable tube and an elongate shaft having a lumen for providing inflation fluid to, or withdrawing inflation fluid from, the balloon. The inflatable tube can be coiled in a helical manner around a central axis into a series of windings. Adjacent windings can be stacked against and bonded to each other, and an inner surface of the series of windings, when inflated, can define the passage. The elongate shaft can be eccentrically attached to a proximal portion of the balloon and the shaft's lumen can be in fluid communication with the interior of the balloon, specifically the inflatable tube. The inflatable tube can include two different polymer tubes, one slightly smaller than the other.

CATHETER

Catheters and methods for supporting a guidewire or delivering a radiopaque, diagnostic or therapeutic agent through a vessel stenosis or other tortuous anatomy are disclosed. A catheter can comprise an elongate shaft body and a tip member disposed at a distal end of the shaft body. The shaft body can extend from a proximal end to the distal end and can define an inner lumen. The shaft body can include a liner, a braid member surrounding the liner, a multi-layer coil surrounding the braid member, and a polymer cover surrounding the multi-layer coil. The multi-layer coil can include first and second coil layers wound in opposing directions. An outer surface portion of the polymer cover can include one or more helical threads. In an example, the one or more helical threads are positioned around a distal end portion of the shaft body. The tip member can be made from a metal or a polymer and can also include one or more helical threads around its outer surface. 1. A catheter , comprising:an elongate shaft body extending from a proximal end to a distal end and defining an inner lumen, the shaft body including a liner, a multi-layer coil surrounding the liner, and a polymer cover surrounding the multi-layer coil,an outer surface portion of the polymer cover including one or more helical threads; anda tip member disposed at the distal end of the shaft body.2. The catheter of claim 1 , wherein the multi-layer coil includes a first coil layer wound in a first direction and a second coil layer claim 1 , surrounding the first coil layer claim 1 , wound in a second direction opposing the first direction.3. The catheter of claim 2 , wherein the first and second coil layers each include a plurality of wound wires having a fully round cross-section.4. The catheter of claim 1 , wherein the polymer cover extends inward through voids between successive windings of the multi-layer coil.5. The catheter of claim 1 , wherein the shaft body further comprises a braid member extending ...

CATHETER

Catheters and methods for supporting a guidewire or delivering a radiopaque, diagnostic or therapeutic agent through a vessel stenosis or other tortuous anatomy are disclosed. A catheter can comprise an elongate shaft body and a tip member disposed at a distal end of the shaft body. The shaft body can extend from a proximal end to the distal end and can define an inner lumen. The shaft body can include a liner, a braid member surrounding the liner, a multi-layer coil surrounding the braid member, and a polymer cover surrounding the multi-layer coil. The multi-layer coil can include first and second coil layers wound in opposing directions. An outer surface portion of the polymer cover can include one or more helical threads. In an example, the one or more helical threads are positioned around a distal end portion of the shaft body. The tip member can be made from a metal or a polymer and can also include one or more helical threads around its outer surface. 1. A method , comprising:guiding a catheter having a shaft body and a tip member over a guidewire, including inserting a proximal end of the guidewire into an inner lumen of the catheter, where the inner lumen is defined along the length of the shaft body, from its proximal portion to its distal end, by a liner, a braid member, a multi-layer coil including a first coil layer and a second coil layer surrounding the first coil layer, and an outer polymer cover;using the guidewire as a rail, advancing a distal end of the catheter to a location proximate a stenosis or narrowing in a blood vessel;rotating the catheter in a first direction, including advancing the catheter into the stenosis or narrowing; andadvancing the guidewire through the stenosis or narrowing with the support of the catheter.2. The method of claim 1 , wherein inserting the proximal end of the guidewire into the inner lumen of the catheter includes inserting the proximal end of the guidewire into the tip member through which the liner extends.3. ...

Vascular dilator systems, kits, and methods

Vascular dilator systems, kits, and methods allowing for sheathless introduction of a treatment device into a body vessel or body cavity are disclosed. A vascular dilator system can include a dilator assembly, including a tubular shaft and a deformable member, and optionally, the treatment device. The deformable member can include a non-biodegradable material and can have a diameter at a proximal end portion that is greater than a diameter at a distal end portion. The distal end portion of the deformable member can be coupled to an outer surface of the tubular shaft, at or near a shaft distal end portion. The proximal end portion of the deformable member can include a diameter configured to receive or stretch around a distal end portion of the treatment device. In use, the deformable member can provide a tapered bridge between the outer surface of the tubular shaft and an outer surface of the treatment device.

DRAINAGE OR FEEDING CATHETER ASSEMBLY

Catheter assemblies, kits and methods allowing for the drainage or administration of fluid or small particles are disclosed. A catheter assembly can include a shaft with a lumen, an expandable retention member, an elongate actuation member and a locking mechanism. The expandable retention member can be positioned at a shaft distal end portion and can include one or more filaments forming a plurality of drainage or administration interstices of variable or uniform size. The elongate actuation member can include an actuation member distal end, directly or indirectly engaged with the expandable retention member, and an actuation member proximal end. Movement of the actuation member proximal end relative to a proximal end of the shaft can cause the expandable retention member to change from a lower-profile configuration to a higher-profile configuration. A moved position of the elongate actuation member can be secured by rotating, sliding or otherwise manipulating the locking mechanism. 1. A catheter assembly , comprising:a shaft having a lumen, extending from a shaft proximal end portion to a shaft distal end portion;an expandable retention member, positioned at the shaft distal end portion, including one or more filaments forming a plurality of drainage or administration interstices;an elongate actuation member, extending from an actuation member proximal end to an actuation member distal end, the actuation member distal end operably engaged with the expandable retention member; anda locking mechanism, positioned at the shaft proximal end portion, configured to move between a first position, in which the elongate actuation member is movable relative to the shaft, and a second position, in which the elongate actuation member is locked relative to the shaft.2. The catheter assembly of claim 1 , further comprising a distal tip having a lumen positioned at claim 1 , and coupled to claim 1 , a distal end portion of the expandable retention member.3. The catheter assembly ...

Elongated expandable member for occluding varicose veins

Assemblies, kits, and methods for occluding a vascular vessel, such as a varicose vein, are disclosed. An assembly can include a removable inner member, a removable outer member, and an elongated expandable member positioned in a compressed form between portions of the inner and outer members. To facilitate their removal, one or both of the inner and outer members can include a handle coupled to a proximal end. The elongated expandable member can include a gelatin material or a collagen material that is configured, when wetted, to expand from a compressed first diametrical size to a second larger diametrical size within a time period of 5 minutes or less. At the second larger diametrical size, the gelatin or collagen material can occlude a vascular vessel for a period of at least 20 days without degrading.

Elongated expandable member for occluding varicose veins

Combined stretch and wipe forming machine with automatic transverse control of the wipe shoe

930,198. Stretch forming; bending. CYRIL BATH CO. April 24, 1962, No. 15473/62. Class 83 (4). A combined stretch and wipe forming machine of the kind having a table 2 upon which is mounted a side face die 25 about which elongated stock 19 is wrapped by holding one end of the stock so as to induce tension loads in it and rotating the table with the die 25 on it, and also having a wipe shoe 30 engageable with the stock at or near the point of contact thereof with the face of the die, has means 46 for traversing the wipe shoe 30 independently of rotation of the table 2, the wipe shoe 30 having means 63, 64 thereon for conveying a signal to the wipe shoe traversing means 46 to adjust the position of the wipe shoe 30 in relation to the instantaneous line of contact between the stock and the side face of the die such that a contact portion of the shoe presses the stock against the side face of the die normally at the instantaneous line of contact between the stock and the side face of the die during rotation of the table 2, the means for conveying a signal to the wipe shoe traversing means being operative to convey a signal to traverse the wipe shoe rearwardly or forwardly. The stock 19 is held in tension by piston and cylinder means 10. The wipe shoe 30 is movable to or from the die 25 by piston and cylinder means 35 mounted on a carriage 34 traversed by the piston and cylinder means 46. To maintain the central part of the wipe shoe 30 generally in contact, contact pins 63, 64 carried at the front and rear of the shoe 30 control a valve 50 controlling the piston and cylinder means 46 so that if the contact 63 or both the contacts 63, 64 together are depressed the shoe 30 is traversed forwardly, i.e. in a direction opposite that of the table travel, while if the contact 64 alone is depressed the shoe is traversed rearwardly. The contact pins 63, 64 may be replaced by microswitches or switches in the form of strain gauges. The shoe may comprise a roll having sensing means ...

Perfusion catheters

Un catéter de perfusión (300, 400, 500, 600), que comprende: un balón (328, 428, 528, 628) que incluye un tubo inflable (340, 740, 840) enrollado de forma helicoidal alrededor de un eje central, en una serie de devanados (342, 542, 642), estando los devanados adyacentes apilados unos contra otros y unidos entre sí, una superficie interior de la serie de devanados, que, al inflarse, define un paso (344, 544, 644) a través del balón (328, 428, 528, 628), incluyendo el tubo inflable (340, 740, 840) dos tubos de polímero (868, 870) diferentes, un tubo interior (868) situado dentro de un tubo exterior (870), que están coextruidos, en donde un polímero del tubo interior (868) está reticulado y tiene una temperatura de fusión más alta que un polímero del tubo exterior (870), que no está reticulado; y un vástago alargado (326, 526, 626, 1026, 1126) que se extiende desde una porción proximal (332) hasta una porción distal (334) e incluye una luz (330, 530, 630, 1130) para proporcionar fluido de inflado al balón (328, 428, 528, 628), o para extraer fluido de inflado del mismo, estando unido el vástago alargado (326, 526, 626, 1026, 1126) excéntricamente a una porción proximal del balón (328, 428, 528, 628), y estando su luz (330, 530, 630, 1130) en comunicación fluídica con el interior del tubo inflable (340, 740, 840). An infusion catheter (300, 400, 500, 600), comprising: a balloon (328, 428, 528, 628) that includes an inflatable tube (340, 740, 840) helically wound around a central axis, in a series of windings (342, 542, 642), the adjacent windings being stacked against each other and joined together, an inner surface of the series of windings, which, when inflated, defines a step (344, 544, 644) through the balloon (328, 428, 528, 628), including the inflatable tube (340, 740, 840) two different polymer tubes (868, 870), an inner tube (868) located inside an outer tube (870 ), which are coextruded, wherein a polymer of the inner tube (868) is crosslinked and has a higher ...

Combined binding post and thermal cut-out

Controlling-valve for vacuum-operated power means.

Catheter

Catheters and methods for supporting a guidewire or delivering a radiopaque, diagnostic or therapeutic agent through a vessel stenosis or other tortuous anatomy are disclosed. A catheter can comprise an elongate shaft body and a tip member disposed at a distal end of the shaft body. The shaft body can extend from a proximal end to the distal end and can define an inner lumen. The shaft body can include a liner, a braid member surrounding the liner, a multi-layer coil surrounding the braid member, and a polymer cover surrounding the multi-layer coil. The multi-layer coil can include first and second coil layers wound in opposing directions. An outer surface portion of the polymer cover can include one or more helical threads. In an example, the one or more helical threads are positioned around a distal end portion of the shaft body. The tip member can be made from a metal or a polymer and can also include one or more helical threads around its outer surface.