26-01-2017 дата публикации
Номер: US20170023591A1
Принадлежит:
Biomarkers, methods, and systems for assessment of traumatic brain injury of different severities, as well as treatment efficacy and blood brain barrier or blood cerebrospinal fluid integrity and assessment of neurodegenerative conditions. The methods include detecting in a patient sample one or more of ubiquitin C-terminal hydrolase LI (UCH-L1), glial fibrillary acid protein (GFAP), aldehyde dehydrogenase 1 family member LI (ALDHILI), phosphorylated neurofilament heavy chain (pNFH), medium chain (NFM), or light chain (NFL), alpha-synuclein, visinin-like protein 1 (VILIP-1) and S100B. 1. A method for assessment of traumatic brain injury of unknown severity , comprising detecting in a patient sample one or more biomarker(s) selected from the group consisting of ubiquitin C-terminal hydrolase L1 (UCH-L1) , glial fibrillary acid protein (GFAP) , aldehyde dehydrogenase 1 family member L1 (ALDH1L1) , phosphorylated neurofilament heavy chain (pNFH) , medium chain (NFM) , or light chain (NFL) , alpha-synuclein , visinin-like protein 1 (VILIP-1) and S100B , and comparing a detection result from said sample to a control for known traumatic brain injury severity for said one or more of said biomarker(s).2. The method of claim 1 , wherein said detecting comprises an antibody-capture method.3. The method of claim 1 , further including detecting a breakdown product or other processed variant of one or more of said ubiquitin C-terminal hydrolase L1 (UCH-L1) claim 1 , glial fibrillary acid protein (GFAP) claim 1 , aldehyde dehydrogenase 1 family member L1 (ALDH1L1) claim 1 , phosphorylated neurofilament heavy chain (pNFH) claim 1 , medium chain (NFM) claim 1 , or light chain (NFL) claim 1 , alpha-synuclein claim 1 , visinin-like protein 1 (VILIP-1) and S100B.4. The method of claim 3 , wherein a detection result from said detecting a breakdown product or other processed variant is followed by comparison to a control for a known neurodegeration disorder or disease.5. The method of ...
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