Hybrid cyclic libraries and screens thereof

Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

Power electronics converter based transformer emulator

A transformer emulator includes a DC bus, a first power electronics converter circuit having a DC port coupled to the DC bus, a second power electronics converter circuit having a DC port coupled to the DC bus, and a third power electronics converter circuit having DC port coupled to the DC bus. The transformer emulator further includes a control circuit configured to control the first, second and third power electronics converter circuits to emulate a transformer having a first port corresponding to an AC port of the first power electronics converter circuit and a second port corresponding to an AC port of the second power electronics converter circuit. The control circuit is configured to control the first and second power electronics converter circuits to emulate a voltage transformation of the transformer and to control the third power electronics converter circuit to emulate a loss of the transformer.

RAPADOCINS, INHIBITORS OF EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1 AND USES THEREOF

A compound of Formula I, 2. A method of inhibiting human equilibrative nucleoside transporter 1 (ENT1) comprising administering to a subject in need thereof an effective amount of the compound of claim 1 , thereby inhibiting ENT1.3. A method of increasing adenosine signaling comprising administering to a subject in need thereof an effective amount of the compound of claim 1 , thereby increasing adenosine signaling.4. The method according to claim 3 , wherein administering the compound results in one or more of the effects selected from the group consisting of an increase in antiviral activity claim 3 , an increase in antiparasitic activity claim 3 , an increase in alcohol tolerance claim 3 , a decrease in pain claim 3 , protection from ischemia claim 3 , attenuation of epileptic seizure severity claim 3 , lessening of erectile dysfunction claim 3 , improvement of liver function claim 3 , improvement of respiratory disorders claim 3 , improvement of sepsis claim 3 , improvement of thrombosis claim 3 , improvement of hypertension claim 3 , improvement of inflammatory disorders claim 3 , improvement of allergies claim 3 , improvement of cardiac ischemias claim 3 , improvement of arrhythmias claim 3 , improvement of Parkinson's disease claim 3 , improvement of chronic heart failure claim 3 , improvement of rheumatoid arthritis claim 3 , improvement of dry eye disease claim 3 , improvement of chronic plaque type psoriasis claim 3 , improvement of chronic neuropathological pain claim 3 , and improvement of sickle cell disease.5. A pharmaceutical composition comprising the compound of and a pharmaceutically acceptable carrier.6. The pharmaceutical composition of claim 5 , wherein the composition is in a dosage form suitable for oral administration claim 5 , rectal administration claim 5 , percutaneous administration or parenteral injection. This application is continuation application of U.S. application Ser. No. 16/073,746 filed Jul. 27, 2018, now pending; which is a 35 ...

POWER ELECTRONICS CONVERTER BASED TRANSFORMER EMULATOR

A transformer emulator includes a DC bus, a first power electronics converter circuit having a DC port coupled to the DC bus, a second power electronics converter circuit having a DC port coupled to the DC bus, and a third power electronics converter circuit having DC port coupled to the DC bus. The transformer emulator further includes a control circuit configured to control the first, second and third power electronics converter circuits to emulate a transformer having a first port corresponding to an AC port of the first power electronics converter circuit and a second port corresponding to an AC port of the second power electronics converter circuit. The control circuit is configured to control the first and second power electronics converter circuits to emulate a voltage transformation of the transformer and to control the third power electronics converter circuit to emulate a loss of the transformer.

Hybrid cyclic libraries and screens thereof

Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

SCALABLE RECONFIGURABLE APPARATUS AND METHODS FOR ELECTRIC POWER SYSTEM EMULATION

An electric power system emulator apparatus includes a plurality of nodes arrayed in first and second dimensions and a plurality of transmission path emulator circuits, respective ones of which are configured to be connected between adjacent ones of the nodes in the first and second dimensions. The apparatus further includes a control circuit configured to control the transmission path emulator circuits to emulate transmission paths of an electric power system. The control circuit may be configured to control the transmission path emulator circuits to emulate transmission lines and/or transformers. The transmission path emulator circuits may include respective power electronics converter circuits. The apparatus may further include source/load emulator circuits configured to be coupled to the nodes.

Power electronics converter based reconfigurable grid emulation platform

A system includes a controller that is configured to generate a node control signal and a plurality of switch control signals, a plurality of programmable emulators, each of the plurality of programmable emulators being configurable as one of a plurality of node types responsive to the node control signal, and a plurality of switches that are programmable to couple ones of the plurality of programmable emulators to each other responsive to the plurality of switch control signals.

HYBRID CYCLIC LIBRARIES AND SCREENS THEREOF

Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits. 1. A macrocyclic compound comprising:an immunophilin-binding domain selected from the group consisting of a FK506-binding protein (FKBP)-binding domain (FKBD) and a cyclosporin-binding cyclophilins (CyP)-binding domain;an effector domain comprising a heteroatom configured to bind a target protein; anda linker moiety connecting the immunophilin-binding domain and the effector domain.2. The macrocyclic compound of claim 1 , wherein the immunophilin-binding domain is an FKBP-binding domain (FKBD).3. The macrocyclic compound of claim 1 , wherein the immunophilin-binding domain is a CyP-binding domain.4. The macrocyclic compound of claim 1 , wherein the heteroatom is nitrogen.5. The macrocyclic compound of claim 1 , wherein the effector domain comprises a polypeptide.6. The macrocyclic compound of claim 5 , wherein the effector domain comprises a tetrapeptide.7. The macrocyclic compound of claim 1 , comprising two linker moieties claim 1 , thereby making the macrocyclic compound with a cyclic sequence of the immunophilin-binding domain claim 1 , a first linker moiety claim 1 , the effector domain claim 1 , and a second linker moiety.8. The macrocyclic compound of claim 1 , wherein the target protein is calcineurin or target of rapamycin (TOR).9. The macrocyclic compound of claim 8 , wherein binding with the target protein leads to inhibition of T cell activation and/or tumor cell growth.10. A pharmaceutical composition comprising the macrocyclic compound of and a pharmaceutically acceptable carrier.11. A method of identifying a macrocyclic compound comprising:(a) contacting ...

Hybrid cyclic libraries and screens thereof

Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

POWER SYSTEM COMPONENT TESTING USING A POWER SYSTEM EMULATOR-BASED TESTING APPARATUS

An apparatus for testing components for use in a power system includes at least one power amplifier circuit configured to be coupled to the component and a control circuit configured to operate the power amplifier circuit responsive to at least one state of a component emulator for the component included in a system emulator for the power system. The component emulator may include at least one power electronics converter circuit and the control circuit may be configured to control at least one of a voltage and a current of the at least one power amplifier circuit responsive to at least one of a voltage and a current of the at least one power electronics converter circuit. The control circuit may be further configured to control the component emulator responsive to at least one state of the at least one power amplifier circuit. 1. An apparatus for testing a component for use in a power system , the apparatus comprising:at least one power amplifier circuit configured to be coupled to the component; anda control circuit configured to operate the power amplifier circuit responsive to at least one state of a component emulator for the component included in a system emulator for the power system.2. The apparatus of claim 1 , wherein the component emulator comprises at least one power electronics converter circuit.3. The apparatus of claim 2 , wherein the control circuit is configured to control at least one of a voltage and a current of the at least one power amplifier circuit responsive to at least one of a voltage and a current of the at least one power electronics converter circuit.4. The apparatus of claim 2 , wherein the component comprises a multi-port component and wherein the at least one power electronics converter circuit comprises at least two power electronics converter circuits.5. The apparatus of claim 1 , wherein the control circuit is configured to control the component emulator responsive to at least one state of the at least one power amplifier circuit.6 ...

HYBRID CYCLIC LIBRARIES AND SCREENS THEREOF

Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

DC CURRENT CONTROLLER FOR CONTINUOUSLY VARIABLE SERIES REACTOR

A direct current controller includes a rectifier configured to convert alternating current input into a direct current output. A converter electrically coupled to the rectifier generates a converted direct current voltage that regulates a converted direct current from the direct current output of the rectifier and synthesizes an ac component of an alternating current grid to counteract an induced back-emf. A direct current controller central controller coupled to the converter regulates the converted direct current.

RAPAGLUTINS, NOVEL INHIBITORS OF GLUT AND USE THEREOF

Compounds with the following structures 2. The method of claim 1 , wherein the compound is Formula A18 or E11.3. An isolated compound of .4. A method of synthesizing a compound of or claim 1 , comprising synthetic scheme I or II.5. The method of claim 1 , wherein the cancer is selected from the group consisting of an alimentary/gastrointestinal tract cancer claim 1 , a liver cancer claim 1 , a skin cancer claim 1 , a breast cancer claim 1 , a pancreatic cancer claim 1 , an ovarian cancer claim 1 , a prostate cancer claim 1 , a lymphoma claim 1 , a leukemia claim 1 , a kidney cancer claim 1 , a lung cancer claim 1 , a muscle cancer claim 1 , a bone cancer claim 1 , bladder cancer claim 1 , a brain cancer claim 1 , eye or ocular cancer claim 1 , rectal cancer claim 1 , colon cancer claim 1 , cervical cancer claim 1 , bladder cancer claim 1 , oral cancer claim 1 , benign and malignant tumors claim 1 , stomach cancer claim 1 , corpus uteri claim 1 , testicular cancer claim 1 , renal cancer claim 1 , throat cancer claim 1 , acute lymphocytic leukemia claim 1 , acute myelogenous leukemia claim 1 , Ewing's Sarcoma claim 1 , Kaposi's Sarcoma claim 1 , basal cell carcinoma and squamous cell carcinoma claim 1 , small cell lung cancer claim 1 , choriocarcinoma claim 1 , rhabdomyosarcoma claim 1 , angiosarcoma claim 1 , hemangioendothelioma claim 1 , Wilms Tumor claim 1 , neuroblastoma claim 1 , mouth/pharynx cancer claim 1 , esophageal cancer claim 1 , larynx cancer claim 1 , neurofibromatosis claim 1 , tuberous sclerosis claim 1 , hemangiomas claim 1 , and lymphangiogenesis.6. The method of claim 5 , wherein the cancer is metastatic cancer.7. The method of claim 1 , wherein the compound is administered intravenously.9. A pharmaceutical composition comprising the compound of or .10. A method of treating possible organ rejection in a subject receiving an organ transplant comprising administering to the subject an effective amount of a compound of claim 1 , thereby treating the ...

Hybrid cyclic libraries and screens thereof

Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

SCALABLE RECONFIGURABLE APPARATUS AND METHODS FOR ELECTRIC POWER SYSTEM EMULATION

An electric power system emulator apparatus includes a plurality of nodes arrayed in first and second dimensions and a plurality of transmission path emulator circuits, respective ones of which are configured to be connected between adjacent ones of the nodes in the first and second dimensions. The apparatus further includes a control circuit configured to control the transmission path emulator circuits to emulate transmission paths of an electric power system. The control circuit may be configured to control the transmission path emulator circuits to emulate transmission lines and/or transformers. The transmission path emulator circuits may include respective power electronics converter circuits. The apparatus may further include source/load emulator circuits configured to be coupled to the nodes.

POWER ELECTRONICS CONVERTER BASED RECONFIGURABLE GRID EMULATION PLATFORM

A system includes a controller that is configured to generate a node control signal and a plurality of switch control signals, a plurality of programmable emulators, each of the plurality of programmable emulators being configurable as one of a plurality of node types responsive to the node control signal, and a plurality of switches that are programmable to couple ones of the plurality of programmable emulators to each other responsive to the plurality of switch control signals. 1. A system , comprising:a controller that is configured to determine terminal current references based on measured terminal voltages for a transmission line type; anda plurality of programmable emulators, each of the plurality of emulators comprising a pair of power converters coupled together, the controller being configured regulate each of the power converters based on the terminal current references.2. The system of claim 1 , wherein each of the plurality of programmable emulators is configurable as a nominal T type transmission line claim 1 , an LR type transmission line with shunt compensation capacitors claim 1 , an LR type transmission line with series compensation capacitors claim 1 , an LR type transmission line with series compensation variable inductors claim 1 , or a Bergeron type transmission line.3. The system of claim 1 , wherein the controller is further configured to generate a node control signal and a plurality of switch control signals claim 1 ,wherein the plurality of programmable emulators is a second plurality of programmable emulators, the system further comprising:a first plurality of programmable emulators, each of the plurality of programmable emulators being configurable as one of a plurality of node types responsive to the node control signal; anda plurality of switches that are programmable to couple ones of the first plurality of programmable emulators to each other responsive to the plurality of switch control signals, to couple ones of the second plurality ...

Synthesis and composition of rapafucin libraries

A Rapafucin library containing compounds of the general structure, (A) and (E), and a synthesis of these compounds are provided.

METHOD, SYSTEM, AND APPARATUS FOR OVERRIDING A RING BACK SIGNAL

Overriding a ring back signal involves receiving a ring back signal at a communications apparatus from a communication network in response to a user-initiated connection request. The ring back signal is rendered to a user of the communications apparatus, and a user input is received at the communications device to override the ring back signal. An alternate output is rendered to the user in place of the ring back signal. 1. A method , comprising:receiving a ring back signal at a communications apparatus from a communication network in response to a user-initiated connection request;rendering the ring back signal to a user of the communications apparatus;receiving a user input at the communications device to override the ring back signal; andrendering an alternate output to the user in place of the ring back signal.2. The method of claim 1 , wherein the alternate output comprises audio content.3. The method of claim 1 , wherein the alternate output comprises video content.4. The method of claim 1 , wherein the alternate output is retrieved from the communication apparatus.5. The method of claim 1 , wherein the communication network comprises a telephonic communication network.6. The method of claim 5 , wherein the telephonic communication network comprises at least one of a cellular network claim 5 , a public switched telephone network claim 5 , and a packet switched data network.7. The method of claim 6 , wherein the connection request spans at least two of the cellular network claim 6 , the public switched telephone network claim 6 , and the packet switched data network.8. The method of claim 1 , further comprising:receiving a call connect signal from the communication network in response to the user-initiated connection request; andstopping the alternate output in response to the call connect signal.9. The method of claim 1 , wherein the ring back signal comprises a personalized ring back tone.10. The method of claim 1 , wherein rendering the alternate output to ...

Method, system, and apparatus for overriding a ring back signal

Overriding a ring back signal involves receiving a ring back signal at a communications apparatus from a communication network in response to a user-initiated connection request. The ring back signal is rendered to a user of the communications apparatus, and a user input is received at the communications device to override the ring back signal. An alternate output is rendered to the user in place of the ring back signal.

HYBRID CYCLIC LIBRARIES AND SCREENS THEREOF

Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

Rapadocins, inhibitors of equilibrative nucleoside transporter 1 and uses thereof

A compound of Formula (I), and its analogs are provided. Compositions that include Formula I can be used to inhibit human equilibrative nucleoside transporter 1, increase adenosine signaling and produce effects that include increasing antiviral activity, increasing antiparasitic activity, increasing alcohol tolerance, decreasing pain protecting from ischemia as well as many other conditions.

Method, system, and apparatus for overriding a ring back signal

Overriding a ring back signal involves receiving a ring back signal at a communications apparatus from a communication network in response to a user-initiated connection request. The ring back signal is rendered to a user of the communications apparatus, and a user input is received at the communications device to override the ring back signal. An alternate output is rendered to the user in place of the ring back signal.

POWER ELECTRONICS CONVERTER BASED RECONFIGURABLE GRID EMULATION PLATFORM

A system includes a controller that is configured to generate a node control signal and a plurality of switch control signals, a plurality of programmable emulators, each of the plurality of programmable emulators being configurable as one of a plurality of node types responsive to the node control signal, and a plurality of switches that are programmable to couple ones of the plurality of programmable emulators to each other responsive to the plurality of switch control signals.

Power system component testing using a power system emulator-based testing apparatus

An apparatus for testing components for use in a power system includes at least one power amplifier circuit configured to be coupled to the component and a control circuit configured to operate the power amplifier circuit responsive to at least one state of a component emulator for the component included in a system emulator for the power system. The component emulator may include at least one power electronics converter circuit and the control circuit may be configured to control at least one of a voltage and a current of the at least one power amplifier circuit responsive to at least one of a voltage and a current of the at least one power electronics converter circuit. The control circuit may be further configured to control the component emulator responsive to at least one state of the at least one power amplifier circuit.

Hybrid Cyclic Libraries and Screens Thereof

Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits. 5. The compound of Formula I of claim 1 , wherein:{'sub': 1', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '3', '3', '2', '2, 'Land Lare each independently —OCHCH—, —CHC(O)—, —CHCHC(O)—, —C(O)NHCHCH, —CHCH═CHCH—, —OCHCH═CHCHCH—, OCHCH═CHCHCH(COH)—, —CHC(O)NHCHCH—, or CHCH(OCH)═C(CH)CHCH; and'}{'sup': 8', '10', '12', '14, 'R, R, R, and Rare each independently the sidechain of the amino acid alanine, asparagine, cysteine, glutamine, glycine, isoleucine, leucine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, or valine.'}8. A method of treating cancer in a patient in need thereof comprising administering a therapeutically effective amount of the compound of Formula I to the patient.9. A method of suppressing the immune system in a patient in need thereof comprising administering a therapeutically effective amount of the compound of Formula I to the patient.11. The method of claim 10 , wherein the reagents benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate (PyBOP) claim 10 , N claim 10 ,N-diisopropylethylamine (DIPEA) claim 10 , and N-methylpyrrolidine (NIMP) are used in coupling.12. The method of claim 11 , wherein the reagent benzylidene[1 claim 11 ,3-bis(2 claim 11 ,4 claim 11 ,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(tricyclohexylphosphine)ruthenium is used in cyclizing.13. A compound of Formula I claim 10 , prepared by the method of .14. A method of identifying compounds from a library of compounds that binds to a protein encoded in a genome in complex with ...

HYBRID CYCLIC LIBRARIES AND SCREENS THEREOF

Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

RAPADOCINS, INHIBITORS OF EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1 AND USES THEREOF

A compound of Formula (I), and its analogs are provided. Compositions that include Formula I can be used to inhibit human equilibrative nucleoside transporter 1, increase adenosine signaling and produce effects that include increasing antiviral activity, increasing antiparasitic activity, increasing alcohol tolerance, decreasing pain protecting from ischemia as well as many other conditions. 2. A method of inhibiting human equilibrative nucleoside transporter 1 (ENT1) comprising administering to a subject in need thereof an effective amount of a compound of claim 1 , thereby inhibiting ENT1.3. A method of increasing adenosine signaling comprising administering to a subject in need thereof an effective amount of a compound of claim 1 , thereby increasing adenosine signaling.4. A method of increasing adenosine signaling comprising administering to a subject in need thereof an effective amount of a compound of claim 1 , wherein the administering of the compound of results in one or more of the effects selected from the group consisting of an increase in antiviral activity claim 1 , an increase in antiparasitic activity claim 1 , an increase in alcohol tolerance claim 1 , a decrease in pain claim 1 , protection from ischemia claim 1 , attenuation of epileptic seizure severity claim 1 , lessening of erectile dysfunction claim 1 , improvement of liver function claim 1 , improvement of respiratory disorders claim 1 , improvement of sepsis claim 1 , improvement of thrombosis claim 1 , improvement of hypertension claim 1 , improvement of inflammatory disorders claim 1 , improvement of allergies claim 1 , improvement of cardiac ischemias claim 1 , improvement of arrhythmias claim 1 , improvement of Parkinson's disease claim 1 , improvement of chronic heart failure claim 1 , improvement of rheumatoid arthritis claim 1 , improvement of dry eye disease claim 1 , improvement of chronic plaque type psoriasis claim 1 , improvement of chronic neuropathological pain and improvement ...

Scalable reconfigurable apparatus and methods for electric power system emulation

An electric power system emulator apparatus includes a plurality of nodes arrayed in first and second dimensions and a plurality of transmission path emulator circuits, respective ones of which are configured to be connected between adjacent ones of the nodes in the first and second dimensions. The apparatus further includes a control circuit configured to control the transmission path emulator circuits to emulate transmission paths of an electric power system. The control circuit may be configured to control the transmission path emulator circuits to emulate transmission lines and/or transformers. The transmission path emulator circuits may include respective power electronics converter circuits. The apparatus may further include source/load emulator circuits configured to be coupled to the nodes.

Method, system, and apparatus for overriding a ring back signal

Overriding a ring back signal involves receiving a ring back signal at a communications apparatus from a communication network in response to a user-initiated connection request. The ring back signal is rendered to a user of the communications apparatus, and a user input is received at the communications device to override the ring back signal. An alternate output is rendered to the user in place of the ring back signal.

DC current controller for continuously variable series reactor

A direct current controller includes a rectifier configured to convert alternating current input into a direct current output. A converter electrically coupled to the rectifier generates a converted direct current voltage that regulates a converted direct current from the direct current output of the rectifier and synthesizes an ac component of an alternating current grid to counteract an induced back-emf. A direct current controller central controller coupled to the converter regulates the converted direct current.

POWER ELECTRONICS BASED RECONFIGURABLE LOAD TESTER

Circuits and methods for testing power electronics devices. In some examples, a reconfigurable load tester includes a power conversion circuit configured to couple to a device under test (DUT). The power conversion circuit includes a number of arms, and each arm includes submodules. Each submodule includes one or more electronically-controlled switches. The reconfigurable load tester includes a controller configured for controlling the electronically-controlled switches of the submodules. The controller is configured for emulating, by controlling the electronically-controlled switches of the submodules, a plurality of electrical load levels/types on the DUT. 1. A reconfigurable load tester comprising:a power conversion circuit configured to couple to a device under test (DUT), the power conversion circuit comprising a plurality of arms, wherein each arm comprises a plurality of submodules each comprising one or more electronically-controlled switches; and controlling the electronically-controlled switches of the submodules; and', 'emulating, by controlling the electronically-controlled switches of the submodules, a plurality of electrical load levels on the DUT., 'a controller configured for2. The reconfigurable load tester of claim 1 , wherein the power conversion circuit is an alternating current (AC) power converter configured for converting AC power to DC power or DC power to AC power or both.3. The reconfigurable load tester of claim 2 , wherein the power conversion circuit comprises a plurality pairs of arms.4. The reconfigurable load tester of claim 3 , wherein claim 3 , for each pair of arms:a first arm is coupled between a positive voltage node of a DC link and an AC voltage node for one phase of the AC power; anda second arm is coupled between the AC voltage node and a negative voltage node of the DC link.5. The reconfigurable load tester of claim 4 , wherein the DUT shares the DC link with the power conversion circuit.6. The reconfigurable load tester of ...

Synthesis and composition of rapafucin libraries

A Rapafucin library containing compounds of the general structure, (A) and (E), and a synthesis of these compounds are provided.

METHOD, SYSTEM, AND APPARATUS FOR OVERRIDING A RING BACK SIGNAL

Overriding a ring back signal involves receiving a ring back signal at a communications apparatus from a communication network in response to a user-initiated connection request. The ring back signal is rendered to a user of the communications apparatus, and a user input is received at the communications device to override the ring back signal. An alternate output is rendered in place of the ring back signal. 1. A method , comprising:receiving a ring back signal at a communications apparatus from a communication network;overriding the ring back signal; andrendering an alternate output via a preconfigured application in place of the ring back signal,wherein the application is based on a context of one of the communications apparatus and a target device to which a connection request is targeted.2. The method of claim 1 , wherein the application is from a plurality of applications of the communications apparatus.3. The method of claim 1 , wherein the ring back signal is received in response to a user initiated connection request.4. The method of claim 1 , wherein the context is an identity of the target device.5. The method of claim 1 , wherein the alternate output comprises video content.6. The method of claim 1 , wherein the alternate output is retrieved from the communications apparatus.7. The method of claim 1 , wherein the communication network comprises a telephonic communication network.8. The method of claim 7 , wherein the telephonic communication network comprises at least one of a cellular network claim 7 , a public switched telephone network claim 7 , and a packet switched data network.9. The method of claim 8 , wherein the connection request spans at least two of the cellular network claim 8 , the public switched telephone network claim 8 , and the packet switched data network.10. The method of claim 1 , further comprising:receiving a call connect signal from the communication network; andstopping the alternate output in response to the call connect signal ...

Rapadocins, inhibitors of equilibrative nucleoside transporter 1 and uses thereof

A compound of Formula I, and its analogs are provided. Compositions that include Formula I can be used to inhibit human equilibrative nucleoside transporter 1, increase adenosine signaling and produce effects that include increasing antiviral activity, increasing antiparasitic activity, increasing alcohol tolerance, decreasing pain protecting from ischemia as well as many other conditions.

Antiviral compounds useful against sars-cov-2

Disclosed herein are compound of Formula I, Formula II, or Formula III: or a pharmaceutically acceptable salt and/or solvate of any one or more thereof, pharmaceutical compositions including such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.

Power electronics based reconfigurable load tester

Circuits and methods for testing power electronics devices. In some examples, a reconfigurable load tester includes a power conversion circuit configured to couple to a device under test (OUT). The power conversion circuit includes a number of arms, and each arm includes submodules. Each submodule includes one or more electronically-controlled switches. The reconfigurable load tester includes a controller configured for controlling the electronically-controlled switches of the submodules. The controller is configured for emulating, by controlling the electronically-controlled switches of the submodules, a plurality of electrical load levels/types on the OUT.

Hybrid cyclic libraries and screens thereof

Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

Hybrid cyclic libraries and screens thereof

Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

Antiviral compounds useful against sars-cov-2

Disclosed herein are compound of Formula I, Formula II, or Formula III: or a pharmaceutically acceptable salt and/or solvate of any one or more thereof, pharmaceutical compositions including such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.

Rapadocins, inhibitors of equilibrative nucleoside transporter 1 and uses thereof

Synthesis and composition of Rapafucin libraries

A Rapafucin library containing compounds of the general structure, (A) and (E), and a synthesis of these compounds are provided.

Method of dry-type desilting for river course

The present application provides a method of dry type desilting for a river course, the river course needs to be set off partially during construction, which is suitable for the river course desilting with a certain space on both banks and convenient for set off construction; furthermore, the river bank is thoroughly desilted, it is easy to control the desilting depth, coupled with high sludge concentration and low transportation cost, so the engineering cost is relatively low. In the whole process, the river desilting is carried out in sections, the preliminary preparation and later construction are carried out at the same time, the construction process is efficient and fast, which not only ensures the smoothness of the river desilting engineering, but also ensures the minimal impact on the surrounding area.

Method of dry-type desilting for river course

The present application provides a method of dry type desilting for a river course, the river course needs to be set off partially during construction, which is suitable for the river course desilting with a certain space on both banks and convenient for set off construction; furthermore, the river bank is thoroughly desilted, it is easy to control the desilting depth, coupled with high sludge concentration and low transportation cost, so the engineering cost is relatively low. In the whole process, the river desilting is carried out in sections, the preliminary preparation and later construction are carried out at the same time, the construction process is efficient and fast, which not only ensures the smoothness of the river desilting engineering, but also ensures the minimal impact on the surrounding area.

Rapaglutins, novel inhibitors of glut and use thereof

Compounds with the following structures and their analogs are provided. Compositions that include these structures can be used to inhibit glucose transporters and stop or decrease the proliferation of cancer, treat possible organ rejection and treat autoimmune disease.

Power electronics converter based reconfigurable grid emulation platform

A system includes a controller that is configured to generate a node control signal and a plurality of switch control signals, a plurality of programmable emulators, each of the plurality of programmable emulators being configurable as one of a plurality of node types responsive to the node control signal, and a plurality of switches that are programmable to couple ones of the plurality of programmable emulators to each other responsive to the plurality of switch control signals.

Power electronics converter based reconfigurable grid emulation platform

A system includes a controller that is configured to generate a node control signal and a plurality of switch control signals, a plurality of programmable emulators, each of the plurality of programmable emulators being configurable as one of a plurality of node types responsive to the node control signal, and a plurality of switches that are programmable to couple ones of the plurality of programmable emulators to each other responsive to the plurality of switch control signals.

Hybrid cyclic libraries and screens thereof

Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

Beschickungsvorrichtung für Kugelhaufenartige Hochtemperaturstacks

Die vorliegende Erfindung betrifft das technische Gebiet der Reaktortechnik und insbesondere eine Beschickungsvorrichtung für Kugelhaufenartige Hochtemperaturstacks. Die Beschickungsvorrichtung für Kugelhaufenartige Hochtemperaturstacks gemäß der vorliegenden Erfindung umfasst: Einen Montageträger; Ein Andruckelement, das unter dem Montageträger angeordnet und in Bezug auf die Höhenrichtung des Montageträgers beweglich ist und dazu geeignet ist, die Öffnung des Brennstoffbehälters anzudrücken oder von der Öffnung des Brennstoffbehälters weg zu bewegen, und mit einem ersten Loch, das in der Höhenrichtung des Montageträgers durch das Andruckelement hindurchgeht, versehen ist; Ein Transferrohr, das dazu geeignet ist, den Brennstoff einzuführen, und das an dem Montageträger angeordnet und in Bezug auf die Höhenrichtung des Montageträgers beweglich ist und bewegbar durch das erste Loch durchgehend angeordnet ist; Ein Pufferelement, dessen eines Ende in dem Transferrohr und in der Nähe des unteren Endes des Transferrohrs angeordnet ist, um den Brennstoff in dem Transferrohr zu verlangsamen; Die Beschickungsvorrichtung für Kugelhaufenartige Hochtemperaturstacks weist einen ersten Zustand, in dem das Andruckelement in der Höhenrichtung des Montageträgers beweglich ist, um die Öffnung des Brennstoffbehälters anzudrücken, und einen zweiten Zustand auf, in dem das Transferrohr in der Höhenrichtung des Montageträgers bewegt wird, um das untere Ende des Transferrohrs in das Innere des Brennstoffbehälters zu bewegen.

Kugelübertragungs- und Strömungsverhinderungsvorrichtung

Die vorliegende Erfindung betrifft das technische Gebiet des Kernreaktors, insbesondere eine Kugelübertragungs- und Strömungsverhinderungsvorrichtung. Die Kugelübertragungs- und Strömungsverhinderungsvorrichtung gemäß der vorliegenden Erfindung umfasst: Einen Kasten, der eine Aufnahmekammer aufweist und der mit einem Kugeleinfuhrrohr und einem Kugelausfuhrrohr versehen ist; Eine Rotorkomponente, die sich zumindest teilweise in der Aufnahmekammer befindet und die einen Rotor und einen Drehteller umfasst, wobei sich der Rotor in einer ersten Richtung erstreckt, wobei ein Ende des Rotors zu einer Verbindung mit einem Antriebselement geeignet ist, um den Rotor anzutreiben, in Bezug auf den Kasten in der ersten Richtung zu drehen, wobei das andere Ende des Rotors mit dem Drehteller verbunden ist, um den Drehteller zu drehen anzutreiben, wobei der Drehteller ein Kugelannahmeteil aufweist, das an dem Kugeleinfuhrrohr oder dem Kugelausfuhrrohr angeschlossen sein kann; Eine Lagerkomponente, die den Rotor umhüllt und die ein erstes Lager und ein zweites Lager umfasst, wobei das erste Lager und das zweite Lager in der ersten Richtung in Abständen angeordnet und auf der gleichen Seite des Drehtellers angeordnet sind.

Wireless charging device with stable connection and charging method thereof

A wireless charging device with a stable connection and a charging method thereof. The wireless charging device has a wireless charging device; the wireless charging device has a wireless charger and a magnetic attraction device, wherein the wireless charger has a charging end face, and the magnetic attraction device has a magnetic attraction part and an adsorption disk, the magnetic attraction part is arranged on the charging end face, and the adsorption disk is adsorbed by the magnetic attraction part to form a detachable connection; wherein, the adsorption disk is fixedly connected to an electronic product, and the electronic product has a protective sleeve; the charging steps are as follows: putting the electronic product to be charged into the protective sleeve; fixing the adsorption disk on the protective sleeve; adsorbing the electronic product to the wireless charger.

Hybrid cyclic libraries and screens thereof

Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.