Processes for preparing amine salts of sildenafil-analogues and use thereof

A series of amine salts including a structure of formula (I) and formula (III) have provided. In formula I or formula (III), R 1 , R a and RX are as defined in the specification. The amine complex salts disclosed in the present invention are characterized in a pro-drug active form and various pharmaceutical function.

Cable connector assembly having an improved grounding means

A cable connector assembly ( 100 ) includes an insulative housing ( 10 ) defining a plurality cavities, a first connector ( 20 ) received in a cavity, a pair of second connector ( 30 ) received in other cavities, a cable electrically connected with the first connector and the second connectors, a metallic shell ( 40 ) shielding on the insulative housing and a capacitor ( 50 ) defined in the insulative housing. The capacitor is assembled behind the connectors, and includes two linking points ( 500, 501 ). The second connector has a plurality of grounding legs ( 300 ) electrically connected with each other, one linking point of the capacitor is connected with one of the grounding legs of the second connector, and the other linking point is connected with the metallic shell.

Theophylline Derivative Inhibits Osteoporosis

The theophylline derivative disclosed in the present invention is characterized by having the pharmaceutical functions of osteoporosis. The theophylline derivative protects against bone resorption and inflammatory mediator infiltration.

Nanop article-oligonucleotide hybrid structures and methods of use thereof

The invention relates to hybrid structures comprising an amphiphilic nucleic acid-block co-polymer assembly on the exterior and a nanoparticle core, and methods of use thereof.

Luminous intensity test device

A luminous intensity test device includes an optical frequency converter, a display, and a processor. The optical frequency converter selectively converts at least a portion of light emitted by a light source into a digital signal. The display displays a color selection interface. The processor processes the digital signal and obtains the luminous intensity. When a tester inputs a color parameter into the color selection interface via an input device, the optical frequency converter converts a kind of light to the digital signal and then the processor processes the digital signal to obtain a luminous intensity and display the luminous intensity on the display.

Process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5.6.8.8a-tetrahydro-1H-imidazo[1,5-a]pyrazin-2-yl]-carboxylic acid

The present invention relates to a process for synthesizing a compound of formula (I), R 1 is phenyl, which is unsubstituted or substituted with one, two or three substituents independently selected from halogen and C 1-6 alkyl; R 2 is C 1-6 alkyl; R 3 is —C x H 2x —; x is 1, 2, 3, 4, 5, 6 or 7; or pharmaceutically acceptable salt or diastereomer thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.

PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED 5-AMINO-6H-THIAZOLO[4,5-d]PYRIMIDINE-2,7-DIONE COMPOUNDS

The present invention relates to a process for synthesizing a compound of formula (I), R 1 is H or C 1-6 alkyl; R 2 is H or hydroxy; or pharmaceutically acceptable salt or diastereomer thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.

Flow cells

An example of a flow cell includes a substrate, a plurality of chambers defined on or in the substrate, and a plurality of depressions defined in the substrate and within a perimeter of each of the plurality of chambers. The depressions are separated by interstitial regions. Primers are attached within each of the plurality of depressions, and a capture site is located within each of the plurality of chambers.

Sense amplifier, memory, and method for controlling sense amplifier

A sense amplifier includes an amplification module and a control module electrically connected to the amplification module. Herein, in a case of reading a data in a memory cell on a first bit line, at an offset compensation stage of the sense amplifier, the control module is arranged to configure the amplification module to include a first diode structure, a first current mirror structure, and a first inverter with an input terminal and an output terminal connected to each other. In a case of reading a data in a memory cell on a second bit line, at the offset compensation stage of the sense amplifier, the control module is arranged to configure the amplification module to include a second diode structure, a second current mirror structure, and a second inverter with an input terminal and an output terminal connected to each other.

Humidifier with a water tub within a pressurized chamber

A tub is configured to contain a supply of water and is configured to be inserted into a chamber of a humidifier. The tub includes a tub base configured to contain the supply of water. The tub also includes a tub lid and a flow plate provided between the tub base and the tub lid. The flow plate includes a water level indicator configured to indicate a level of the supply of water in the tub base. In addition, the water level indicator includes a generally rectangular portion and a generally triangular portion.

Smart socket for automatically switching between electricity utilization modes

The present invention is to provide a smart socket, which includes a timing unit for obtaining current time; a power receiving/output unit for receiving electricity from an external power supply or outputting electricity to a power storage device; an electricity quantity monitoring unit for detecting power value of electricity received from the power receiving/output unit; a home appliance power supply unit and an electricity selling power supply unit for transmitting electricity to an electronic device and an electricity purchaser circuit, respectively; a switching unit connected to the electricity quantity monitoring unit, home appliance power supply unit and electricity selling power supply unit, and being set with a home appliance mode, a power storage mode and an electricity selling mode; and a processing unit connected to the timing unit, electricity quantity monitoring unit and switching unit for switching mode of the switching unit according to the current time and power value.

Heat dissipation unit and heat dissipation device using same

A heat dissipation unit and a heat dissipation device using same are disclosed. The heat dissipation device includes a base and one or more heat dissipation units. The base has a first side and an opposite second side; and the heat dissipation units respectively include at least one radiation fin correspondingly provided on the first side of the base. The radiation fin is formed by correspondingly closing a first plate member and a second plate member to each other, such that a plurality of independent flow channels is defined between the closed first and second plate member. And, the independent flow channels respectively have an amount of working fluid filled therein.

Manufacturing method of cole plate structure

A manufacturing method of a cold plate structure comprises a plate body and a pipe. The plate body has a first side and a second side. A groove is formed on the second side. The pipe is embedded in the groove correspondingly. The pipe is filled with a gas. By means of the design of the present invention, the oxidation on the inner wall of the pipe can be avoided. Consequently, the operating efficiency is significantly increased and the manufacturing cost is reduced.

Welding column combination and power supply module thereof

A welding column combination includes at least two metal welding columns and at least one insulator block. Each metal welding column has a first end and a second end opposite to the first end, wherein at least one of the metal welding columns has welding surfaces at the first end and the second end respectively. The at least one insulator block assembles the at least two metal welding columns as a unitary physical combination.

Method for optimizing the selection of the iol to be implanted in an eye

A method for selecting an intraocular lens (IOL), to optimize the results of refractive procedures on the eye. According to the invention, the method for selecting the IOL includes: a) determining the required biometrical parameters of the eye; b) using the parameters for a corresponding eye model; c) evaluating, using ray tracing, the data of an IOL to be implanted; d) selecting, on the basis of said data, an IOL to be implanted; and e) repeating the method steps c) and d) for further suitable IOLs. To optimize the method, different measuring methods are used to determine the biometrical parameters, a corresponding patient-specific eye model is identified, and, when selecting the IOL, additional retinal image metrics are taken into consideration alongside the determined data. The method according to the invention permits the optimized selection of a spherical, aspheric, toric or multifocal IOL for implantation.

Process for the Preparation of 1-([1,3]dioxolan-4-ylmethyl)-1H-pyrazol-3-ylamine

The present invention relates to a novel process for the preparation of of the formula (I) (I) wherein R 1 and R 2 are described herein. The compounds prepared by the present invention are useful in the synthesis and manufacture of compounds for treating diseases or conditions associated with inhibiting actin polymerization.

Process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidine analogues

The present invention relates to a process for synthesizing a compound of formula (I), (I), wherein R 1 is phenyl, which is unsubstituted, or once, twice or three times substituted by halogen; R 2 is C 1 - 6 alkyl; R 3 is heterocyclyl; and diastereomer, pharmaceutically acceptable salts thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.

Process for the preparation of 1-([1,3]dioxolan-4-ylmethyl)-1h-pyrazol-3-ylamine

The present invention relates to a process for the preparation of of the formula (I) wherein R1 and R2 may be hydrogen, alkyl, cycloalkyl, phenyl etc. The compounds prepared by the present invention are useful in the synthesis and manufacture of compounds for treating diseases or conditions associated with inhibiting actin polymerization.

Humidification of respiratory gases

Hydrogel beads for nucleotide sequencing

Systems, methods, and compositions provided herein relate to preparation of beads encapsulating genetic material. Some embodiments include preparation of nucleic acid libraries within the bead, wherein the bead includes pores that allow diffusion of reagents while retaining genetic material.

Humidification of respiratory gases

Flow cells

Sequencing kits

An example of a sequencing kit includes a flow cell, an encapsulation matrix precursor composition, and a radical initiator. The flow cell includes a plurality of chambers and primers attached within each of the plurality of chambers. The encapsulation matrix precursor composition consists of a fluid, a monomer or polymer including a radical generating and chain elongating functional group, a radical source, and a crosslinker. The radical initiator is part of the encapsulation matrix precursor composition or is a separate component.

Spatial indexing of genetic material and library preparation using hydrogel beads and flow cells

Implementations of a method for seeding sequence libraries on a surface of a sequencing flow cell that allow for spatial segregation of the libraries on the surface are provided. The spatial segregation can be used to index sequence reads from individual sequencing libraries to increase efficiency of subsequent data analysis. In some examples, hydrogel beads containing encapsulated sequencing libraries are captured on a sequencing flow cell and degraded in the presence of a liquid diffusion barrier to allow for the spatial segregation and seeding of the sequencing libraries on the surface of the flow cell. Additionally, examples of systems, methods and compositions are provided relating to flow cell devices configured for nucleic acid library preparation and single cell sequencing. Some examples include flow cell devices having a hydrogel with genetic material disposed therein, and which is retained within the hydrogel during nucleic acid processing.

Humidifier with a water tub within a pressurized chamber

A tub is configured to contain a supply of water and is configured to be inserted into a chamber of a humidifier. The tub includes a tub base configured to contain the supply of water. The tub also includes a tub lid and a flow plate provided between the tub base and the tub lid. The flow plate includes a water level indicator configured to indicate a level of the supply of water in the tub base. In addition, the water level indicator includes a generally rectangular portion and a generally triangular portion.

Process for the preparation of n-[3-(aminomethyl)oxetan-3-yl]carbamate intermediates

The present invention relates to a novel process for the preparation of a compound of the formula (I): and pharmaceutically acceptable acid addition salts thereof, which is useful for prophylaxis and treatment of respiratory syncytial virus (RSV) infection in mammal or human being.

Registration system and method for robot-oriented augmented reality teching system

The invention relates to a registration system for robot-oriented augmented reality teaching system, comprising: a physical robot unit, a registration unit, a virtual robot generation unit and a computer; the physical robot unit comprising a physical robot, a physical robot controller and a robot point-to-point intermittent movement control program; the physical robot provided thereon with a physical robot base coordinate system; the physical robot controller connected with the physical robot and the computer respectively, the robot point-to-point intermittent movement control program installed in the computer; the registration unit comprising a registration marker, a camera and a conversion calculation unit; the registration marker arranged on the physical robot body; the camera fixed in a physical environment except the physical robot; the camera connected with the computer, and the conversion calculation unit arranged in the computer; the virtual robot generation unit arranged in the computer and used for generating a virtual robot model.

Radiating fin

Method for determining the topography of the cornea of an eye

Die vorliegende Erfindung betrifft ein Verfahren zur Bestimmung der Topografie der Kornea eines Auges, basierend auf einer optischen, berührungslosen Datenerfassung. Bei dem erfindungsgemäßen Verfahren zur Bestimmung der Topografie der Kornea eines Auges basierend auf einem deflektometrischen Verfahren, erfolgt die deflektometrischen Messungen mit Hilfe eines keratometrischen Verfahrens, indem in den keratometrischen Messpunkten zusätzlich OCT-basierte Scans realisiert werden, wobei die beiden Messsysteme zueinander registriert sind und sowohl die keratometrischen als auch die OCT-basierten Messwerte aufgenommen und zur gegenseitigen Kalibrierung verwendet werden, um daraus die topografischen Daten zu berechnen und auszugeben. Das vorgeschlagene Verfahren dient der Bestimmung der Topografie der Kornea eines Auges. Die Ermittlung der Topografie ist erforderlich, um Rückschlüsse auf mögliche krankhafte Veränderungen treffen zu können. Zudem ist die exakte Vermessung der Hornhauttopografie für die Korrektur von Refraktionsfehlern von großer Bedeutung. The present invention relates to a method for determining the topography of the cornea of an eye, based on an optical, non-contact data acquisition. In the method according to the invention for determining the topography of the cornea of an eye based on a deflektometric method, the deflectometric measurements are carried out with the aid of a keratometric method by additionally realizing OCT-based scans in the keratometric measuring points, wherein the two measuring systems are registered with each other and both The keratometric and OCT-based measurements are taken and used for mutual calibration to calculate and output the topographical data. The proposed method serves to determine the topography of the cornea of an eye. The determination of the topography is necessary in order to be able to draw conclusions about possible pathological changes. In addition, the exact measurement of corneal topography for the correction ...

Process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5,6,8,8a-tetrahydro-1H-imidazo[1,5-a]pyrazin-2-yl]-carboxylic acid

PROCESS FOR THE PREPARATION OF 4-PHENYL-5 ALKOXYCARBONYL-2-THIAZOL-2-YL-1,4-DIHYDROPYRIMIDIN-6 YLIMETHYL-3-OXO-5,6,8,8A-TETRAHYDRO-IH-IMIDAZO[1,5 A]PYRAZIN-2-YLI-CARBOXYLIC ACID Abstract 0 2 N N Y H N N N o \ Ra H O 0 The present invention relates to a process for synthesizing a compound of formula (I), R 1 is phenyl, which is unsubstituted or substituted with one, two or three substituents independently selected from halogen and CI-6alkyl; R2 is C- 6alkyl; R3 is -CxH2x-; x is 1, 2, 3, 6 or 7; or pharmaceutically acceptable salt or diastereomer thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepat-itis B infection.

Guaiacoxypropanolamines with alpha/beta adrenergic blocking activity

The invention reveals a novel structure of guaiacoxypropanolamines shown in formula I The composition comprising formula I as active intergant and pharmaceutical acceptable vehicle. The effects of composition by perfect administration routes in the mammal when given potential α/β-adrenergic blocking activity, selective for emergency hypertension.

Theophylline derivative inhibits osteoporosis

The theophylline derivative disclosed in the present invention is characterized by having the pharmaceutical functions of osteoporosis. The theophylline derivative protects against bone resorption and inflammatory mediator infiltration.

Buffer packaging

A buffer packaging is provided. The buffer packaging includes a main body and at least one support plate. The main body is stretchable in a stretching direction and includes at least one receiving hole. The at least one support plate is connected with the main body and is swingable between a first position and a second position.

Vapor-liquid phase fluid heat transfer module

A vapor-liquid phase fluid heat transfer module includes: at least one evaporator having a first chamber inside, which containing a first working medium; at least one evaporator tube body having a first end, a second end and a condensation section positioned, the first and second ends communicating with the first chamber of the at least one evaporator to form a loop of the first working medium; at least one heat exchanger having a heat exchange chamber, a first face and a second face for the condensation section of the evaporator tube body to attach to; and at least one heat sink tube body, which communicating with the heat exchange chamber of the at least one heat exchanger and the at least one heat sink to form a loop of the second working medium.

Power generating method of carbon-molecule gasification combustion boiler

A power generating method of Carbon-molecule gasification combustion, the method comprising the following main processes: taking coal with desulfurizing agent, and first conducting desulphuration and gasification in a molecular gasifier to produce clean coal gas; mixing hot coal gas and low excess air for combustion in the furnace of a boiler; conducting coke refining and dust removal according to coal quality and demand; after heat transfer via the heated surface of the boiler, emitting high temperature flue gas complying with the standard from the chimney; and the vapor generated by the boiler drives a steam turbine to generate power. The gasification method can be applied to a power generating system of a gas engine and a gas turbine to produce desired cooling coal gas, and can also produce chemical feed gas. The method has wide applicability and a simple process, is safe to operate and is environmentally friendly and energy saving.

Manufacture of locking elements for semiconductor manufacturing

Flow cells

An example of a flow cell includes a substrate, a plurality of chambers defined on or in the substrate, and a plurality of depressions defined in the substrate and within a perimeter of each of the plurality of chambers. The depressions are separated by interstitial regions. Primers are attached within each of the plurality of depressions, and a capture site is located within each of the plurality of chambers.

Humidification of respiratory gases

A respiratory apparatus (10) for delivering a flow of breathable gas to a patient, comprising a flow generator (12) and a humidifier (14), the flow generator being configured to generate a flow of breathable gas (24), and the humidifier comprising a humidifier chamber (16) and a tub (20), the tub being configured to contain a supply of water and being insertable into the humidifier chamber, the humidifier further comprising a humidifier lid (18) attached to a wall of the humidifier chamber and pivotable between an open position in which the tub is insertable from the top into the humidifier chamber and a closed position in which the humidifier lid covers the inserted tub, the humidifier chamber further comprising an inlet (22) configured to receive the flow of breathable gas generated by the flow generator, a bottom with a heating plate configured to heat the supply of water contained in the tub, a back wall (55) with an opposing front retaining wall (33), and two opposing lateral sides, said inlet being provided on one of the opposing lateral sides, wherein the tub comprises a tub base (82) and a tub lid (86), and wherein the flow generator and the humidifier are connectable with the lateral side with the inlet relative to the flow generator so that latches are received in corresponding recesses or catches.

Detachable embedded illumination device

本發明提供一種可拆卸式嵌入照明裝置，尤指一種包含有可拆卸式自動發光模組之可拆卸式嵌入照明裝置(如崁燈)。其中該拆卸式自動發光模組，包含有複數個採用COB封裝之發光單元及供電單元(如鋰電池或充電電池)同時設於同一基板上，以構成之。故整體而言，該可拆式自動發光模組係具有相較於一般LED發光模組或電源模組較小之尺寸與新穎設計；並兼具有COB封裝發光單元之散熱功能，以及可便於其直接或重複拆卸與再裝設之優點，並可進而改善一般照明裝置於裝設、維修等時需重新連接供電電路，或甚至整組更換等之諸多不便；又，基於其便於拆卸之設計，亦可於直接拆卸下後，單獨作為手持照明使用(如手電筒)。

Process for the preparation of n-(3-(aminomethyl)oxetan-3-yl)carbamate intermediates

Electrical connector assembly

An electrical connector assembly ( 100 ) includes a connector holder ( 2 ) defining a plurality of positioning cavities ( 2101 ) therein, and at least a slot ( 2103 ) located in a front portion of each of the positioning cavities; a plurality of grounding members ( 5 ) respectively mounted to the positioning cavities, each of the grounding members ( 5 ) having a body portion ( 50 ), a first contacting portion ( 51 ) connected to a front edge of the body portion, a second contacting portion ( 52 ) connected to a back edge of the body portion and at least an arm ( 53 ) connected to a lateral edge of the body portion, said at least an arm received in the at least a slot, and the first contacting portion disposed out of the connector holder; a plurality of connectors respectively mounted to the positioning cavities, each of the connectors having a metallic shell contacting the second contacting portion; and a metallic cage ( 4 ) enclosing the connector holder and the connectors, with the first contacting portion contacting inner surface of the metallic cage.

Process for the preparation of n-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxo-3,5-dihydro-1,4-benzothiazepin-4-yl)-6-methyl-quinazolin-4-amine

The present invention relates to a novel process for the preparation of a compound of the formula (I) and pharmaceutically acceptable acid addition salts thereof, which is useful for prophylaxis and treatment of respiratory syncytial virus (RSV) infection in mammal or human being.

(Pentaphenyl)phenyl Group Containing Compound, Polymeric Derivative Thereof And Method For Forming The Same

The present invention discloses an iridium complex containing a (pentaphenyl)phenyl ligand, having the following general equation: in which G is primary ligand, R′ and R″ are auxiliary ligands. On the other hand, the present invention discloses a compound with a 9-[(pentaphenyl)phenyl]carbazole structure and its polymeric derivative.

Power on detection circuit

A power-on-detection (POD) circuit includes first and second comparators, a voltage divider, a detection circuit coupled to a first voltage source node and the voltage divider, and logic circuitry coupled to outputs of the first and second comparators. The detection circuit outputs a control signal identifying if a first voltage source node has a voltage potential that is higher than ground. The control signal turns on and off the first and second comparators, which are respectively coupled to first and second nodes of the voltage divider and to a reference voltage node. The logic circuitry outputs a power identification signal based on the signals received from the outputs of the first and second comparators.

Methods for chemical ligation of nucleic acids

Provided herein are methods for preparing nucleic acid libraries, capturing DNA obtained from a limited number of cells, and selectively cleaving ssDNA or dsDNA using various chemical ligation and click chemistry reactions described herein.

Theophylline and 3-isobutyl-1-methylxanthine based N-7 substituted derivatives displaying inhibitory activies on PDE-5 phosphodiesterase

Compounds of the theophylline and 3-isobutyl-1-methylxanthine (IBMX) based on N-7 substituted derivatives, X being florine, chlorine, bromine or iodine, are provided. These compounds possess pharmacologically inhibitory activities on PDE-5 Phosphodiesterase, relaxation of corpus carvernosal smooth muscle and increase of intracarvernosal pressure (ΔICP). A process is also provided for the synthesis of some novel theophyline derivatives.

Gluing device

Panax notoginseng broken wall preparation

本發明係關於一種中藥製劑，具體來說，本發明係關於一種三七破壁製劑，包括將三七粉碎成為超細粉體，再進一步通過乙醇-水濕法製粒，並在一定的轉速下擠壓成型，乾燥，由此製得的三七破壁製劑具有較高的生物利用率，並且製劑穩定性強、崩解性好。

Lid structure with foldable stirring device

Commercial fleet dispatch system and method

Improved structure of cup cover

Process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5,6,8,8a-tetrahydro-1h-imidazo[1,5-a]pyrazin-2-yl]-carboxylic acid

The present invention relates to a process for synthesizing a compound of formula (I), R 1 is phenyl, which is unsubstituted or substituted with one, two or three substituents independently selected from halogen and C 1-6 alkyl; R 2 is C 1-6 alkyl; R 3 is -C x H 2x -; x is 1, 2, 3, 6 or 7; or pharmaceutically acceptable salt or diastereomer thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.

Mobile communication device

Active matrix organic light emitting diode (AMOLED) module structure and the assembling method thereof

本發明涉及一種AMOLED顯示技術領域，尤指一種AMOLED模組結構及其組裝方法。該結構包括依次設置的顯示模組、OCA光學膠層、油墨層以及蓋板玻璃，該油墨層設置於該蓋板玻璃背面的端部，與該蓋板玻璃圍合形成有一圍合空間；該AMOLED模組結構還包括一OCR水膠層，該OCR水膠層填覆於該圍合空間內，該OCA光學膠層將該蓋板玻璃的背面與該顯示模組粘合在一起。本發明可有效地減薄AMOLED模組結構的厚度。

New 3-alkyl-7-(2-(amino or piperazino)-ethyl)-1-methyl-xanthine derivatives, are phosphodiesterase V inhibitors useful for relaxing the corpus cavernosum

D eriv es N-3, 7 substitu es de la 1-m ethylxanthine de formule I et II, (CF DESSIN DANS BOPI) Utilisation de ces compos es pour induire une relaxation caverneuse.

Fiber-optic assay apparatus based on phase-shift interferometry

Apparatus and method for detecting the presence or amount or rate of binding of an analyte in a sample solution is disclosed. The apparatus includes an optical assembly having first and second reflecting surfaces separated by a distance “d” greater than 50 nm, where the first surface is formed by a layer of analyte-binding molecules, and a light source for directing a beam of light onto said first and second reflecting surface. A detector in the apparatus operates to detect a change in the thickness of the first reflecting layer resulting from binding of analyte to the analyte-binding molecules, when the assembly is placed in the solution of analyte, by detecting a shift in phase of light waves reflected from the first and second surfaces.

Process for the preparation of n-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxo-3,5-dihydro-1,4-benzothiazepin-4-yl)-6-methyl-quinazolin-4-amine

The present invention relates to a novel process for the preparation of a compound of the formula (I) and pharmaceutically acceptable acid addition salts thereof, which is useful for prophylaxis and treatment of respiratory syncytial virus (RSV) infection in mammal or human being.

Process for the preparation of 3-substituted 5-amino-6h-thiazolo[4,5-d]pyrimidine-2,7-dione compounds

The present invention relates to a process for synthesizing a compound of formula (I), R1 is H or C1-6alkyl; R2 is H or hydroxy; or pharmaceutically acceptable salt or diastereomer thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.

Method for monitoring fabrication parameter

A method for monitoring fabrication parameters comprises steps of: obtaining a normal parameter variance curve and a comparing parameter variance curve; defining a plurality of normal parameter points on the normal parameter variance curve; defining a plurality of comparing parameter points on the comparing parameter variance curve; finding out the corresponding comparing parameter points nearest to the normal parameter points; calculating the distances between the normal parameter points and the corresponding comparing parameter points thereof; summing up the distances so as to receive a total distance; and determining whether or not the total distance exceeds a limit. Via this arrangement, when fabrication parameter of tool is abnormal, it can be efficiently and immediately determined.

Angle control device of spanner

Hinge device and keyboard

Synthesized β-adrenergic blockers derivatives of guaiacol

Compounds of formula I ##STR1## in which OR 1 is --OR 3 NR 4 , in which R3 is a secondary alcohol group with 1.0 to 6 carbon atoms; a cyclic oxygen containing group with two carbon atoms; a pyridylmethyl or a piperidyl-ethyl group, R 2 is alkyl, an ester group, an aldehyde group, a carboxylic acid group or a ketone group with 3 to 6 carbon --O--CONHR 9 atoms, the group O--R 7 NCOR 8 or the group --O--CONHR 9 in which R 4 is an alkyl group with 1 to 8 carbon atoms, R 7 is an alkylene group with 1 to 6 carbon atoms, each of R 8 and R9 is an alkyl group with 1 to 12 carbon atoms and their pharmaceutically acceptable acid addition salts, are selective β-blockers, antagonists of platelet aggregation, and β-receptor binding. The processes of preparation, compositions, method of treatment are also described.

Spirodiamine derivatives as aldosterone synthase inhibitors

The invention provides compounds having the general formula (I) pharmaceutical compositions containing the compounds and a process for their preparation. The compounds act as aldosterone synthase inhibitors and are for use in the treatment or prevention of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome.

Vasomolol: an ultra short-acting and vasodilatory vanilloid type β.sub. - adrenoceptor antagonist

This invention is related to novel vasomolol, compounds of this invention have the following formula wherein R 1 represents C 1-4 alkyl group. ##STR1## vasomolol is an ultra short-acting and vasodilatory selective β 1 -adrenoceptor antagonist, and is devoid of ISA. Vasomolol is an utra short acting and vasodilatory selective β 1 -adrenoceptor antagonist, and is devoid of IA. The ultra short-acting and vsodilatory β 1 -adrenoceptor blocking activities of vasomolol-a guaiacoxypropanolamine derivative of vanillic acid ethyl ester--were studied. Vasomolol (0.5, 1.0, 3.0 mg/kg, I.v.) produced a dose-dependent bradycardia rsponse, and particularly a hypotensive action with an ultra short-acting property in pentobarbital-anesthetized normotensive rats. Vasomolol's steady-state of β-blockade was attained within 10 min after initiation of an infuson and a rapid recovery from blockade took place after termination of the infusion. In isolated rat aorta, vasomolol (10 -6 M-10 -5 M) inhibit both henylephrine (10 -6 M) and High K + (75 mM)--induced smooth muscle contractions, concentration-dependently. This inhibitory effect of vasomolol was more sensitive on K + than on phenylephrine-induced contractions.

Electronic device with connection interface

Yield loss prediction method and associated computer readable medium

Spatial indexing of genetic material and library preparation using hydrogel beads and flow cells

Novel chiral resolution of 4-aryl-2-thiazol-2-yl-1,4-dihydropyrimidine-5-carboxylic acid esters

The present invention relates to a process for the preparation of an enantiomerically pure of 4-phenyl-6-methyl-2-thiazol-2-yl-1,4-dihydropyrimidine-5-carboxylic acid ester of formula (la), wherein R 1 is phenyl once, twice or more times substituted by halogen; R 2 is C 1_6 alkyl.

Processes for preparing piperazinium salts of kmup and use thereof

A series of quaternary piperazinium salts including a structure of formula (I) or (II) are provided. In formula (I) or (II), RX represents a mineral acid, an organic acid or a commercial drug containing a carboxyl moiety selected from a group consisting of the statins, the fibric acid derivatives for lowering blood lipid, the NSAIDs, the anti-asthmatic drug, the anti-diabetic drug and the prostacyclin, which can be ionically bonded with piperazine moiety. The quarternary piperazinium salts of KMUP compounds can be used as prodrugs and have multiple therapeutic functions.

Spatial Indexing of Genetic Material and Library Preparation Using Hydrogel Beads and Flow Cells

Implementations of a method for seeding sequence libraries on a surface of a sequencing flow cell that allow for spatial segregation of the libraries on the surface are provided. The spatial segregation can be used to index sequence reads from individual sequencing libraries to increase efficiency of subsequent data analysis. In some examples, hydrogel beads containing encapsulated sequencing libraries are captured on a sequencing flow cell and degraded in the presence of a liquid diffusion barrier to allow for the spatial segregation and seeding of the sequencing libraries on the surface of the flow cell. Additionally, examples of systems, methods and compositions are provided relating to flow cell devices configured for nucleic acid library preparation and single cell sequencing. Some examples include flow cell devices having a hydrogel with genetic material disposed therein, and which is retained within the hydrogel during nucleic acid processing.

Obtaining information from a biological sample in a flow cell

Methods are used for obtaining, cataloguing, and/or storing data derived from a biological source using a flow cell body, electrodes, and an imaging assembly. The data may include DNA and/or RNA obtained from a biological source, such as from the cells of an organism. The methods may be used to obtain, catalog, and/or store data such as DNA or RNA sequence from a pathogen such as a virus and/or a bacteria, human health data over time, and immune system information from an individual. The data obtained using the disclosed methods may be used for a variety of different purposes, including the manufacture of vaccine compositions, and for restoring the immune system of an individual who has undergone an immune system depleting event. The methods may be used for storage of biological cells, which may be used for the screening of compounds, such as small molecules with potential for therapeutic indications.

Anti-inflammation activity of newly synthesized xanthine derivatives kmup-1 and kmup-3

An anti-inflammation substrate for decreasing the proinflammation induced by the cytokines and inhibiting the lung function degeneration is provided. The anti-inflammation substrate includes one selected from the group consisting of a 7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine, a 7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine, a respective pharmaceutical acceptable salt thereof, and a combination thereof.

Flow cell, method for introducing a fluid and kit

célula de fluxo, método para introduzir um fluido e kit. um exemplo de uma célula de fluxo inclui um substrato e um hidrogel polimérico catiônico sobre o substrato. o hidrogel polimérico catiônico inclui uma porção catiônica que é i) integrada a uma unidade monomérica de um hidrogel polimérico inicial ou ii) fixada à unidade monomérica do hidrogel polimérico inicial através de um ligante. a célula de fluxo inclui adicionalmente um primer de amplificação fixado ao hidrogel polimérico catiônico. flow cell, method for introducing a fluid and kit. an example of a flow cell includes a substrate and a cationic polymeric hydrogel on the substrate. the cationic polymeric hydrogel includes a cationic moiety which is i) integrated into a monomer unit of an initial polymeric hydrogel or ii) attached to the monomer unit of the initial polymeric hydrogel by a linker. the flow cell additionally includes an amplification primer attached to the cationic polymeric hydrogel.

Foldable bed with high safety performance

Method for inhibiting a liver disease

A method for inhibiting a liver disease is provided. The method includes administering a pharmaceutical composition of one of a piperazine analogue and a piperazine analogue complex to a warm-blooded animal suffering from the liver disease.

Process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5,6,8,8a-tetrahydro-1h-imidazo[1,5-a]pyrazin-2-yl]-carboxylic acid

The present invention relates to a process for synthesizing a compound of formula (I), R1 is phenyl, which is unsubstituted or substituted with one, two or three substituents independently selected from halogen and C1-6alkyl; R2 is C1-6alkyl; R3 is -CxH2x-; x is 1, 2, 3, 6 or 7; or pharmaceutically acceptable salt or diastereomer thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.

Process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5,6,8,8a-tetrahydro-1H-imidazo[1,5-a]pyrazin-2-yl]-carboxylic acid

R1 is phenyl, which is unsubstituted or substituted with one, two or three substituents independently selected from halogen and C1-6alkyl; R2 is C1-6alkyl; R3 is —CxH2x—; x is 1, 2, 3, 4, 5, 6 or 7; or pharmaceutically acceptable salt or diastereomer thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.

Intelligent watch having card type expansion module

System and method for testing an led and a connector thereof

A system for testing a Light emitting diode (LED) and connectors thereof is disclosed. The system includes: a chip ( 10 ) having General purpose input output (GPIO) function and a plurality of pins ( 101 ), a tackle ( 30 ), a parallel interface ( 40 ), and a programmable device ( 50 ). The programmable device ( 50 ) comprising: a setting module ( 501 ), a pin initializing module ( 502 ), a potential controlling module ( 503 ), a data capturing module ( 504 ), and a comparing module ( 505 ). A related method is also disclosed.

Humidifier with a water tub within a pressurized chamber

A tub is configured to contain a supply of water and is configured to be inserted into a chamber of a humidifier. The tub includes a tub base configured to contain the supply of water. The tub also includes a tub lid and a flow plate provided between the tub base and the tub lid. The flow plate includes a water level indicator configured to indicate a level of the supply of water in the tub base. In addition, the water level indicator includes a generally rectangular portion and a generally triangular portion.

Process for the preparation of 1-([1,3]dioxolan-4-ylmethyl)-1h-pyrazol-3-ylamine

Sequencing kits

An example of a sequencing kit includes a flow cell, an encapsulation matrix precursor composition, and a radical initiator. The flow cell includes a plurality of chambers and primers attached within each of the plurality of chambers. The encapsulation matrix precursor composition consists of a fluid, a monomer or polymer including a radical generating and chain elongating functional group, a radical source, and a crosslinker. The radical initiator is part of the encapsulation matrix precursor composition or is a separate component.

Methods and compositions for preparing nucleic acid libraries

Systems, methods and compositions provided herein relate to the preparation of nucleic acid libraries. Some embodiments include the preparation of nucleic acid libraries by ligation of single-stranded nucleic acids.

Flow cells

An example of a flow cell includes a substrate and a cationic polymeric hydrogel on the substrate. The cationic polymeric hydrogel includes a cationic moiety that is i) integrated into a monomeric unit of an initial polymeric hydrogel or ii) attached to the monomeric unit of the initial polymeric hydrogel through a linker. The flow cell further includes an amplification primer attached to the cationic polymeric hydrogel.

Theophylline derivative inhibits osteoporosis

Microcellular foaming process for producing low density thermoplastic polyurethane foam

The invention relates to a process to produce low density thermoplastic polyurethane (TPU) foam via microcellular foaming process, which includes introducing a counter pressure gas into a mold to build up a counter pressure and the mold has venting holes distributed all over the mold. The present invention also relates to the low density TPU foam thus obtained and to the use of the foam in sports goods or shoe sole.

Respirator

Multi-window switching method and switching system

A multi-window switching method and a switching system are provided. The multi-window switching method includes following steps: displaying a first window screen provided via a first computer device and a second window screen provided via a second computer device, wherein a first screen boundary of the first window screen is adjacent to a second screen boundary of the second window screen; receiving a control signal provided by an input device to control a position of a cursor on the first window screen or the second window screen; calculating a first moving speed of the input device when the cursor touches the first screen boundary in the first window screen; and determining whether the first moving speed is greater than or equal to a preset speed threshold to decide whether the cursor is displayed in the second window screen.

Humidification of respiratory gases

Disclosed is a humidifier (14) for humidifying a flow of breathable gas to be delivered to a patient. The humidifier includes a chamber (16) configured to receive the flow of breathable gas; a tub (20) configured to contain a supply of water, the tub being configured to be inserted into the chamber; a lid (18) provided on the chamber and being movable between an open position and a closed position; and a seal (19) provided on the lid, the seal being configured to seal the chamber such that the flow of breathable gas pressurizes the chamber. The humidifier may be connectable to a flow generator (12) configured to generate the flow of breathable gas. A tube for delivering the humidified flow may be connected to the humidifier. The tube may be a heated or non-heated tube. A respiratory apparatus for delivering a flow of breathable gas to a patient may include the humidifier and the flow generator and/or the tube.

Process for the preparation of 1-([1,3]dioxolan-4-ylmethyl)-1h-pyrazol-3-ylamine

The present invention relates to a novel process for the preparation of of the formula (I) (I) wherein R1 and R2 are described herein. The compounds prepared by the present invention are useful in the synthesis and manufacture of compounds for treating diseases or conditions associated with inhibiting actin polymerization.

Obtaining information from a biological sample in a flow cell

Methods are used for obtaining, cataloguing, and/or storing data derived from a biological source using a flow cell body, electrodes, and an imaging assembly. The data may include DNA and/or RNA obtained from a biological source, such as from the cells of an organism. The methods may be used to obtain, catalog, and/or store data such as DNA or RNA sequence from a pathogen such as a virus and/or a bacteria, human health data over time, and immune system information from an individual. The data obtained using the disclosed methods may be used for a variety of different purposes, including the manufacture of vaccine compositions, and for restoring the immune system of an individual who has undergone an immune system depleting event. The methods may be used for storage of biological cells, which may be used for the screening of compounds, such as small molecules with potential for therapeutic indications.

Chip scale package

Multi-window switching method and switching system

A multi-window switching method and a switching system are provided. The multi-window switching method includes following steps: displaying a first window screen provided via a first computer device and a second window screen provided via a second computer device, wherein a first screen boundary of the first window screen is adjacent to a second screen boundary of the second window screen; receiving a control signal provided by an input device to control a position of a cursor on the first window screen or the second window screen; calculating a first moving speed of the input device when the cursor touches the first screen boundary in the first window screen; and determining whether the first moving speed is greater than or equal to a preset speed threshold to decide whether the cursor is displayed in the second window screen.

Synthesis and pharmacokinetic activities of pulmodil and pulmodil-1, two chlorophenylpiperazine salt derivatives

Fiber-Optic Assay Apparatus Based On Phase-Shift Interferometry

Apparatus and method for detecting the presence or amount or rate of binding of an analyte in a sample solution is disclosed. The apparatus includes an optical assembly having first and second reflecting surfaces separated by a distance “d” greater than 50 nm, where the first surface is formed by a layer of analyte-binding molecules, and a light source for directing a beam of light onto said first and second reflecting surface. A detector in the apparatus operates to detect a change in the thickness of the first reflecting layer resulting from binding of analyte to the analyte-binding molecules, when the assembly is placed in the solution of analyte, by detecting a shift in phase of light waves reflected from the first and second surfaces.

Meter monitoring device

SPIRODIAMINE DERIVATIVES AS INHIBITORS OF ALDOSTERONE SYNTHASE

Se refiere a derivados de espirodiamina de formula (I), donde R1, R2, R3 y R4 son H, alquilo o cicloalquilo o R1 y R2 forman -CH2-CH2-; R5, R6, R7, R8, R9 y R10 son H o alquilo; A1 es -CH- o -N-; A2 es -C(O)- o S(O)2-; R12 es heteroarilo opcionalmente sustituido; R13 es halogeno, ciano, entre otros; R15 es H, alquilo, entre otros; R9 y R14 o R10 y R11 forman -CH2-; m y p son 0 o 1; n es 1. Es un compuesto preferido: 5-cloro-3,3-dimetil-2-[5-[2-(1-metilpirazol-4-carbonil)-2,6-diazaspiro[3.3]heptan-6-il]-3-piridil]isoindolin-1-ona. Tambien se refiere a una composicion farmaceutica y a un procedimiento de preparacion. Dichos compuestos actuan inhibiendo la enzima aldosterona sintasa siendo utiles en el tratamiento de enfermedades tales como enfermedad renal cronica, insuficiencia cardiaca, entre otras

Correction method for parameters of long-orbit satellite image

Sequencing kits

An example of a sequencing kit includes a flow cell and an encapsulation matrix precursor composition. The flow cell includes a plurality of chambers and primers attached within each of the plurality of chambers. The encapsulation matrix precursor composition consists of a fluid and a polymer selected from the group consisting of agar, agarose, alginate, heparin, alginate sulfate, dextran sulfate, hyaluronan, pectin, carrageenan, gelatin, chitosan, cellulose, a collagen polymer, and combinations thereof.

Buffer packaging

A buffer packaging is provided. The buffer packaging includes a main body and at least one support plate. The main body is stretchable in a stretching direction and includes at least one receiving hole. The at least one support plate is connected with the main body and is swingable between a first position and a second position.