Active pulse blood consituent monitoring

Systems and Methods for Getting a Baby to Sleep Using Adaptive Adjustments

A system includes a first interface engine and a routine determining engine. The first interface engine interfaces with a scheduling program and retrieves from the scheduling program. The routine determining engine determines a routine from a from the schedules of the users and schedule for the user to execute the routine to get a baby or child to sleep through the night. The routine determining engine determines the routine and the schedule based on the schedules of the user and optimal routine to get a baby or child to sleep through the night.

Multi-purpose tool and tension mechanism

A tool is provided. The tool may include a handle, a frame, and a removable saw blade including at least one hole on one end thereof and at least one hole on another end thereof. The tool may also include a compensating clip configured to attach the removable saw blade to the frame and to provide tension for the removable saw blade. The compensating clip may include a plate including a clip hook, and the plate further includes an opening where a compensator spring is provided. The clip hook is configured to attach onto the at least one hole of the removable saw blade to attach the saw blade to the frame.

Creating a market growth strategy and commercial investment analysis

A technique for performing commercial venture analysis involves establishing an empirically-derived structure and evaluating companies using analytical techniques within that structure. The technique may involve defining jobs, or goals a customer is attempting to reach, with dozens or even hundreds of outcomes. Ideally, the structure and tools facilitate analysis that would not be possible otherwise. Moreover, the nature of the system enables real-time input for changing conditions and the ability to calculate returns for new markets in which products or services do not exist. A computer program product and business method is described for generating a market growth strategy. The computer program product in a computer-readable medium having instructions for directing a computer to focus on the core job that needs to be performed. A specific sequence is executed in several phases: market selection, target generation, business generation and portfolio generation strategies.

Compositions useful in treatment of ornithine transcarbamylase (otc) deficiency

Viral vectors comprising engineered hOTC DNA and RNA sequences are provided which when delivered to a subject in need thereof are useful for treating hyperammonemia, ornithine transcarbamylase transcarbamylase deficiency and symptoms associated therewith. Also provided are methods of using hOTC for treatment of liver fibrosis cirrhosis in OTCD patients by administering hOTC.

Method for controlling a modular energy system user interface

A method for controlling a user interface of a modular energy system. The modular energy system comprises a header module and a display screen on which the user interface is displayed. The modular energy system can detect attachment of a first module thereto, control the user interface to display one or more first user interface elements corresponding to the first module, detect attachment of a second module to the modular energy system, control the user interface to resize the one or more first user interface elements to accommodate display of one or more second user interface elements corresponding to the second module, and control the user interface to display the one or more second user interface elements. The various UI elements can correspond to the particular module type that is being connected to the modular energy system.

Selecting virtual objects in a three-dimensional space

Systems and methods for interacting with virtual objects in a three-dimensional space using a wearable system are disclosed. The wearable system can be programmed to permit user interaction with interactable objects in a field of regard (FOR) of a user. The FOR includes a portion of the environment around the user that is capable of being perceived by the user via the AR system. The system can determine a group of interactable objects in the FOR of the user and determine a pose of the user. The system can update, based on a change in the pose or a field of view (FOV) of the user, a subgroup of the interactable objects that are located in the FOV of the user and receive a selection of a target interactable object from the subgroup of interactable objects. The system can initiate a selection event on the target interactable object.

Mobile device cooling and performance management

Disclosed is a mobile device. The mobile device may be located proximate a mobile terminal and controlled by the mobile terminal. The mobile device may include a processor and a memory. The memory may store instructions that, when executed by the processor, cause the processor to: determine a mode of operation of the mobile device, determine a thermal profile for the mode of operation of the mobile device, and implement a power profile to achieve the thermal profile.

Public safety systems and methods for providing emergency access to private networks

Disclosed herein are public safety systems and methods for providing private network access to a user device. An exemplary public safety system is configured to communicate with a plurality of private networks and a communications network. The exemplary public safety system is configured to receive an emergency notification identifying a first private network of the plurality of private networks. The exemplary public safety system is configured to select the first private network. The exemplary public safety system is configured to provision the first private network to accept a configuration credential. The exemplary public safety system is configured to send through the communications network the configuration credential to a user device, thereby provisioning a subscriber identification module (SIM) in the user device to access the first private network.

Magnetic josephson junction driven flux-biased superconductor memory cell and methods

Magnetic Josephson junction driven flux-biased superconductor memory cell and methods are provided. A memory cell may include a magnetic Josephson junction (MJJ) superconducting quantum interference device (SQUID) comprising a first MJJ device and a second MJJ device, arranged in parallel to each other, where the MJJ SQUID is configured to generate a first flux-bias or a second flux-bias, where the first flux-bias corresponds to a first direction of current flow in the MJJ SQUID and the second flux-bias corresponds to a second direction of current flow in the MJJ SQUID. The memory cell may further include a superconducting metal-based superconducting quantum interference device (SQUID) including a first Josephson junction (JJ) and a second JJ, arranged in parallel to each other, where each of the first JJ and the second JJ has a critical current responsive to any flux-bias generated by the MJJ SQUID.

A method of detecting and/or identifying adeno-associated virus (aav) sequences and isolating novel sequences identified thereby

A method for detecting and isolating AAV sequences in a sample of DNA obtained from tissue or cells is provided. The invention further provides AAV sequences identified by this method, and vectors constructed using these sequences.

loaded resins and method for the production of loaded resins

Stirred tube reactor and method of using the same.

Un metodo proporcionado para elaborar un dispositivo que comprende nanoparticulas semiconductoras alineadas y un sustrato receptor que comprende las etapas de: a) alinear una pluralidad de primeras nanoparticulas semiconductoras; b) depositar las primeras nanoparticulas semiconductoras en la primera hoja donadora; y c) transferir al menos una porcion de las primeras nanoparticulas semiconductoras a un sustrato receptor por la aplicacion de radiacion laser. Tipicamente, las nanoparticulas semiconductoras son nanoparticulas semiconductoras inorganicas. La etapa de alineacion puede ser lograda por cualquier metodo conveniente, tipicamente incluyendo: 1)alineacion por flujo capilar en o en una superficie texturizada o microcanalizada; 2)alineacion por templado de una monocapa auto-ensamblada (SAM); 3)alineacion por templado sobre una superficie de polimero texturizado; o 4)alineacion por mezclado en una composicion que incluye cristales liquidos nematicos seguidos por orentacion cortada de los cristales liquidos nematicos. En algunas modalidades, el metodo adicionalmente comprende las etapas de:d)alinear una segunda pluralidad de segundas nanoparticulas; e)depositar las segundas nanoparticulas alineadas en la misma hoja donadora o una segunda hoja donadora; y f)transferir al menos una porcion de las segundas nanoparticulas alineadas al mismo sustrato receptor por la aplicacion de radiacion laser. Las segundas nanoparticulas pueden ser particulas conductoras, a particulas no conductoras, o a nanoparticulas semiconductoras, incluyendo nanoparticulas semiconductoras inorganicas, y pueden ser de la misma o diferente composicion de las primeras nanoparticulas no conducidas. Adema, los dispositivos elaborados de conformidad a los metodos de la presente invencion son proporcionados.

A continuous process for the production of combinatorial libraries of materials

A system is provided wherein a plug flow reactor is used to make combinatorial libraries of materials. Examples of plug flow reactors include stirred tube reactors, extruders, and static mixers.

Continuous ink jet printing process and apparatus

MODIFIED HEPATOCYTES AND THEIR USE

Veterinary composition and methods for non-surgical neutering and castration

System and method for location optimization for BDMS

A system and method for determining an optimum geographic location using a system of systems. A Design of Experiments is conducted for a particular system of systems architecture using a simulation engine based upon a predefined set of inputs, and Response Surface Models (RSMs) are generated based on the results. The RSMs are evaluated to determine candidate points to minimize or maximize the desired response(s). A candidate geographic location point is set, and one or more truth runs are performed for values in a set of defined second level values. The RSMs are updated based on such truth runs. The process of optimizing, performing a truth run and updating is repeated until the optimal value of the selected variable converges toward a global minimum or maximum, or a predetermined threshold number of iterations is exhausted. The optimum geographic location is designated as the final candidate geographic location point.

Compositions and methods for treating mpsi.

Se proporciona un vector que tiene un casete de expresión que contiene un gen de IDUAh que tiene una secuencia de la SEQ ID NO: 1 o una secuencia al menos 95% idéntica a la misma que codifica una alfa-L-iduronidasa humana funcional; el vector puede ser un vector de producción o un rAAV8; también se proporcionan composiciones, que contienen estos vectores y métodos de tratamiento de MPSI y los síntomas asociados con los síndromes de Hurler, HurlerScheie y Scheie.

Lighter device with flow restrictor and methods of manufacturing and testing same

A lighter device having a flow restrictor and associated methods for manufacturing and testing such lighter device and flow restrictor are described. The flow restrictor may be formed of a porous member to achieve a substantially fixed or varying flame height. The flow restrictor may be tested before or after assembly into a lighter housing by receiving a non-combustible fluid therethrough. The flow rate of the non-combustible fluid may be correlated to the flow rate of a combustible fluid through the flow restrictor to approximate the resultant flame height of a lighter incorporating the tested flow restrictor. The flow restrictor may also be tested by receiving a combustible fluid therethrough prior to assembling the flow restrictor into the lighter housing. In this manner, flow restrictors and corresponding lighter devices may be tested without introducing combustible fluids into such lighter devices prior to shipment. Also, a vacuum may be drawn on a fuel tank of the lighter prior to shipment.

COAXIAL TERMINAL STRUCTURE FOR A PRESSURE WATERPROOF BATTERY.

L'invention est destinée à une batterie étanche sous pression comportant une enveloppe (1) renfermant des éléments (2) reliés à des pôles (12, 9). Une unité de borne pré-montée (15) s'étend à travers une bride annulaire (17) fixée à l'intérieur d'une ouverture dans la paroi de l'enveloppe (1); elle comporte une électrode interne (25), une électrode externe (22), concentrique à l'extérieur de l'électrode interne (25) et isolée de celle-ci, et un élément de montage tubulaire (16) concentrique à l'extérieur de l'électrode externe (22) et isolé de celle-ci. Ces trois éléments sont munis de filetages externes au même pas. L'unité de borne (15) est installée en vissant l'élément de montage (16) dans la bride (17), et simultanément l'électrode externe (22) dans un écrou (11) relié à l'un des pôles (9) et l'électrode interne (25) dans un écrou (14) relié à l'autre (12). L'élément de montage (16) peut être serti vers l'intérieur pour étanchéifier les trois éléments concentriques (16, 22, 25). The invention is intended for a sealed pressure battery comprising an envelope (1) containing elements (2) connected to poles (12, 9). A pre-mounted terminal unit (15) extends through an annular flange (17) fixed inside an opening in the wall of the enclosure (1); it comprises an internal electrode (25), an external electrode (22), concentric outside the internal electrode (25) and isolated from the latter, and a tubular mounting element (16) concentric outside of the external electrode (22) and isolated from it. These three elements are provided with external threads at the same pitch. The terminal unit (15) is installed by screwing the mounting element (16) into the flange (17), and simultaneously the external electrode (22) in a nut (11) connected to one of the poles ( 9) and the internal electrode (25) in a nut (14) connected to the other (12). The mounting element (16) can be crimped inwards to seal the three ...

Compressed-gas insulated circuit breaker operating mechanism

46,257 ABSTRACT OF THE DISCLOSURE A compressed-gas insulated circuit breaker including two spaced apart electrical conductors within a sealed housing, a stationary contact electrically connected to one of the conductors, and a movable contact connected to the other conductor. The movable contact is coupled to a drive mechanism comprising a contact rod secured to the movable contact at one end, and pivotally coupled to a connecting rod at its other end. The connecting rod is pivotally coupled to one of a pair of arms fixedly secured to a rotatable positioning shaft. The other arm is pivotally coupled to a drive rod, and the drive rod is pivotally coupled to a centrally rotatable drive latch. The drive latch is secured to a rotation means, and upon rotation of the drive latch, the drive rod is moved, causing a rotation of the positioning shaft. Upon rotation of the positioning shaft, the connecting rod is moved, causing a longitudinal movement of the contact rod and the movable contact.

ELECTRICAL HEATING DEVICE FOR DEFROSTING BLADES OF A PROPELLER OF AN ENGINE OF AN AIRCRAFT.

La présente invention concerne un dispositif de chauffage d'une pale, pour le dégivrage d'une pale d'un propulseur d'un moteur d'un aéronef, comprenant'une pluralité d'éléments (25-56). Ce dispositif est caractérisé en ce que la résistance électrique de chacun de ces éléments (25-56) varie de manière à faire varier la puissance dissipée par les éléments (25-56) en fonction de la distance entre chacun de ces éléments (25-56) et le bord d'attaque de la pale. The present invention relates to a device for heating a blade, for defrosting a blade of a propellant of an aircraft engine, comprising a plurality of elements (25-56). This device is characterized in that the electrical resistance of each of these elements (25-56) varies so as to vary the power dissipated by the elements (25-56) as a function of the distance between each of these elements (25- 56) and the leading edge of the blade.

Circuit interrupter

Audio tone construction for an energy module of a modular energy system

An audio control system for a modular energy system. The audio control system can include a first controller and a second controller. The first controller can be configured to output an audio signal and an audio signal ID associated with the audio signal. The second controller can be coupled to the first controller and configured to receive the audio signal ID from the first controller and determine whether the audio signal ID corresponds to an expected audio signal ID.

Compositions for targeting conducting airway cells comprising adeno-associated virus constructs

An artificial AAV capsid comprising a heterologous conducting airway targeting sequence is provided. The artificial AAV is useful as a targeting moiety, for delivery of heterologous molecules which are associated therewith. The artificial AAV is also useful in the generation of AAV vectors having the artificial capsid. Also described are methods of modifying the native tropism and transduction efficiency of vectors by improving and/or ablating their ability to transduce conducting airway cells. Methods of targeting conducting airway cells and delivering therapeutic and other molecules thereto are also provided.

Selectively actuatable lighter

A selectively actuatable lighter device (10) is disclosed which includes a body defining reservoir (12) for containing a com-bustible gaseous medium such as butane, and having a valve (20) arranged to be selectively actuated between a normally closed position and an open position which permits the exit of the gaseous medium. Such lighter (10) can selectively produce sparks at a location (19, 22) proximate to the gaseous medium exit to ignite the gaseous medium. Such lighter device (10) embodies a resi-liently releasable valve actuator (14) which normally prevents actuation of the valve (22). The valve actuator (14) includes an inter-fering portion (14A) which is selectively movable to a position out of interference with an interfering portion (12B) of the lighter body, so that the gaseous medium may be released and ignited by the sparks. Once the valve actuator (14) is depressed and re-leased, it returns to its closed or latched position to prevent actuation of the valve to the open position. To "re-use" the lighter, the valve actuator (14) must again be moved to an unlatched position so that the valve (22) can be actuated for subsequent ignition of the gaseous medium.

Multimodal task execution and text editing for a wearable system

Examples of wearable systems and methods can use multiple inputs (e.g., gesture, head pose, eye gaze, voice, and/or environmental factors (e.g., location)) to determine a command that should be executed and objects in the three-dimensional (3D) environment that should be operated on. The multiple inputs can also be used by the wearable system to permit a user to interact with text, such as, e.g., composing, selecting, or editing text.

Amphibian

Lipid system for filler composition

ABSTRACT A sandwich cream filling composition comprising a fat matrix consistingessentially of a plastic fat of defined SFI profile and melt point and a hard butter also of defined SFI profile and melt point, said composition being characterized as having good stand-up throughout a wide temperature range from about about 50°F to about 90°F and an imperceptible solids content at temperatures above about 98.5°F.

Lighter with guard

Selectively actuatable lighter

Method of concentrating a slurry containing a solid particulate component

Modified adenovirus hexon protein and uses thereof

Compositions for drg-specific reduction of transgene expression

Provided herein is a recombinant AAV (rAAV) comprising an AAV capsid and a vector genome packaged therein, wherein the vector genome comprises an AAV 5 and#39; inverted terminal repeat (ITR), an engineered nucleic acid sequence encoding a gene product for expression in target cells, and miRNA target sequences which selectively repress expression in dorsal root ganglion (DRG) cells. Also provided is a pharmaceutical composition comprising a rAAV as described herein in a formulation buffer, and a method of treating a human subject with CNS -targeted gene therapy while selectively preventing expression in DRG cells.

Message transmitting system for reproduction machines and copiers

A copy reproduction machine is subdivided into discrete operating modules and coupled together by a shared communication line over which operating messages from and to the modules are transmitted. Each module includes a receiver for intercepting and capturing messages bearing the module's address and a transmitter for transmitting messages from the module and addressed to other modules over the shared communication line.

Water closet

Selectively actuatable lighter

A selectively actuatable lighter device (10) is disclosed which includes a body defining reservoir (12) for containing a combustible gaseous medium such as butane, and having a valve (20) arranged to be selectively actuated between a normally closed position and an open position which permits the exit of the gaseous medium. Such lighter (10) can selectively produce sparks at a location (19, 22) proximate to the gaseous medium exit to ignite the gaseous medium. Such lighter device (10) embodies a resiliently releasable valve actuator (14) which normally prevents actuation of the valve (22). The valve actuator (14) includes an interfering portion (14A) which is selectively movable to a position out of interference with an interfering portion (12B) of the lighter body, so that the gaseous medium may be released and ignited by the sparks. Once the valve actuator (14) is depressed and released, it returns to its closed or latched position to prevent actuation of the valve to the open position. To 're-use' the lighter, the valve actuator (14) must again be moved to an unlatched position so that the valve (22) can be actuated for subsequent ignition of the gaseous medium.

Method of Modifying a Synthetically Generated Analysis Using Measured Properties on Whole Crude Oil

Den foreliggende oppfinnelsen er en fremgangsmåte for å modifisere enhver syntetisk generert analyse av en hel råolje eller en del av en hel råolje slik som et kondensat eller residmateriale, ved å anvende målte råoljeegenskaper. Disse målte egenskapene anvendes for å justere de syntetiserte analyseverdien for å oppnå en mer nøyaktig representasjon av det ukjente hydrokarbonmaterialet. ?? ?? ?? ?? 1 The present invention is a method of modifying any synthetically generated analysis of an entire crude oil or a portion of an entire crude oil such as a condensate or residual material, using measured crude oil properties. These measured properties are used to adjust the synthesized assay value to obtain a more accurate representation of the unknown hydrocarbon material. ?? ?? ?? ?? 1

Selectable lighter.

Recombinant adeno-associated virus

Synchronizing apparatus

Synchronizing apparatus is disclosed in accordance with the teachings of the present invention wherein the operation of a first device is regulated in accordance with the operation of a second device. The phase relationship between signals representing the operation of the first and second devices, respectively, is determined by comparison means which produces a pulse width modulated signal indicative of said phase relationship. Control signal generating means responds to the pulse width modulated signal to generate an analog signal having an amplitude established by said phase relationship. Feedback means, including variable frequency generating means, is controlled by the analog signal to modify the operation of the first device whereby said first device is urged into a synchronous relationship with said second device and the signals representative of the operation of said first and second devices admit of a desired phase relationship.

Light-emitting user input device

A light emitting user input device can include a touch sensitive portion configured to accept user input (e.g., from a user's thumb) and a light emitting portion configured to output a light pattern. The light pattern can be used to assist the user in interacting with the user input device. Examples include emulating a multi-degree-of-freedom controller, indicating scrolling or swiping actions, indicating presence of objects nearby the device, indicating receipt of notifications, assisting pairing the user input device with another device, or assisting calibrating the user input device. The light emitting user input device can be used to provide user input to a wearable device, such as, e.g., a head mounted display device.

Amphibian

Cigarette lighter with safety latch for gas valve

Method and apparatus for voice latency reduction in a voice-over-data wireless communication system

A METHOD AND APPARATUS FOR REDUCING VOICE LATENCY IN A VOICE-OVER-DATA WIRELESS COMMUNICATION SYSTEM . IN A TRASNMITTER (400), DATA FRAMES ARE CREATED FROM AUDIO INFORMATION BY A VOCODER (406) AND STORED IN A QUEUE (408).PRIOR TO STORAGE, SOME OF THE DATA FRAMES ARE ELIMINATED, OR DROPPED, AND ARE NOT STORED IN THE QUEUE (408). IN A RECEIVER (600), DATA FRAMES ARE GENERATED FROM RECEIVED SIGNALS AND STORED IN A QUEUE (612). PRIOR TO STORAGE IN THE RECEIVER QUEUE (612), SOME OF THE DATA FRAMES ARE DROPPED. DATA FRAMES ARE DROPPED EITHER AT A SINGLE FIXED RATE, A DUAL FIXED RATE, OR A VARIABLE RATE, GENERALLY DEPENDING ON A COMMUNICATION CHANNEL LATENCY.BY DROPPING DATA FRAMES AT THE TRANSMITTER (400), THE RECEIVER (600), OR BOTH (400,600), VOICE LATENCY DUE TO DATA FRAME RETRANSMISSION IS REDUCED.(FIG 7)

Compositions and methods for use of defensin

Method to extend whole grain flour and product shelf life

A stabilized flour, such as stabilized whole grain wheat flour, exhibiting unexpectedly superior extended shelf life and superior biscuit baking functionality, may be produced with or without heating to inhibit lipase by subjecting whole grains or a bran and germ fraction or component to treatment with a lipase inhibitor, such as an acid or green tea extract. Treatment with the lipase inhibitor may be performed during tempering of the whole grains or berries or during hydration of the bran and germ fraction or component.

Method for certifying composition and property variables of manufactured petroleum products

Eclipse cursor for virtual content in mixed reality displays

Systems and methods for displaying a cursor and a focus indicator associated with real or virtual objects in a virtual, augmented, or mixed reality environment by a wearable display device are disclosed. The system can determine a spatial relationship between a user-movable cursor and a target object within the environment. The system may render a focus indicator (e.g., a halo, shading, or highlighting) around or adjacent objects that are near the cursor. When the cursor overlaps with a target object, the system can render the object in front of the cursor (or not render the cursor at all), so the object is not occluded by the cursor. The object can be rendered closer to the user than the cursor. A group of virtual objects can be scrolled, and a virtual control panel can be displayed indicating objects that are upcoming in the scroll.

Methods and systems for production of low water activity fillings

A method and system for making a low-water activity filling, such as crème type fillings, is provided. The fillings advantageously can be used with rotary sandwiching machines without the need for a cooling tunnel downstream of the scraped-surface heat exchanger in the production line. The fillings produced herein comprise a fat component and sugar source, and the fat in the filling has the desired crystallinity. The process and system described herein unexpectedly achieve both a desired nucleation and crystallization rate and crystal structure, as well as the resulting increased filling firmness, in the fillings produced therewith.

Fat Bloom Inhibiting Food Compositions and Methods

Shelf stable non-refrigerated food products having base-cake, filling and coating components with fat bloom inhibiting characteristics and low fat migration. One embodiment provides a food composition having a base-cake having canola oil and having moisture content in a range of about 1.7 to 3.1 percent; a crème filling having a non-lauric fat, and having a water activity level of about 25; and a coating having lauric fat and a non-lauric fat, and having less than about 1 percent moisture.

Method of making gas diffusion layers for electrochemical cells

A method is provided for making a gas diffusion layer for an electrochemical cell comprising the steps of: a) combining carbon particles and one or more surfactants in a typically aqueous vehicle to make a preliminary composition, typically by high shear mixing; b) adding one or more highly fluorinated polymers to said preliminary composition by low shear mixing to make a coating composition; and c) applying the coating composition to an electrically conductive porous substrate, typically by a low shear coating method.

Lighter with guard

The lighter (10) of the present invention provides a resiliently deformable guard (60) that covers a portion of the striking wheel assembly (14). To operate the lighter (10), a user asserts sufficient pressure to depress the guard (60) before rotating the striking wheel assembly (14). The present invention provides retention mechanisms (61) to make removal of the guard (60) more difficult. Further, the lighter (10) of the present invention provides brake members (46) to prevent the rotation of the striking wheel assembly (14) when the user attempts to release fuel prior to rotating the striking wheel assembly (14).

Multi-purpose tool

INFLATABLE DEVICE FOR EFFECTIVE STRUCTURE PROTECTION.

UN APARATO Y UN METODO PARA FABRICAR UN COLCHON PROTECTOR INFLABLE, AUTODESCARGABLE, DE BAJO COSTO Y DE DISEÑO ESTRUCTURALMENTE EFICAZ Y SIMPLE, CON UNA FORMA Y UNA CONSTRUCCION QUE OPTIMIZA LA CAPACIDAD DEL COLCHON PARA RESISTIR LAS PRESIONES DEL INFLADO Y DEL IMPACTO CUANDO SE DESPLIEGA, QUE INCLUYE UNA LAMINA (20) DE UN MATERIAL ENTRELAZADO DE AL MENOS 420 HEBRAS, DEFINIDO POR, AL MENOS, UNA LINEA DE PLEGADO (22) Y UNA CANTIDAD DETERMINADA DE PARTES DE ALETA (23), CADA PARTE DE ALETA TIENE UN BORDE DE BASE (24) QUE SE CORRESPONDE CON LA LINEA DE PLEGADO (23) Y, AL MENOS, DOS BORDES LATERALES (25) CADA UNO DE LOS CUALES SE PROLONGA HACIA AFUERA DESDE EL BORDE DE LA BASE (24) Y CONVERGEN FINALMENTE HASTA COINCIDIR UNO CON OTRO, ESTANDO LAS PARTES DE ALETAS PLEGADAS POR LAS LINEAS DE PLEGADO (22) Y UNIENDOSE POR SUS CORRESPONDIENTES BORDES LATERALES (25) PARA DEFINIR UNA CAMARA DE INFLADO. EL COLCHON PROTECTOR INFLABLE Y EL METODO PARA FABRICAR EL COLCHON PROTECTOR PUEDE INCLUIR, ADEMAS, UNTEJIDO LIGERO, DE BAJA PERMEABILIDAD, QUE OPTIMIZA LA CAPACIDAD DEL COLCHON PARA RESISTIR LAS PRESIONES DEL INFLADO Y DEL IMPACTO CUANDO SE DESPLIEGA Y MINIMIZA EL VOLUMEN DE EMBALAJE DEL COLCHON CUANDO ESTA ALMACENADO. A DEVICE AND METHOD FOR MANUFACTURING A LOW-COST, INFLATABLE, SELF-DOWNLOADABLE, PROTECTIVE MATTRESS WITH A STRUCTURALLY EFFECTIVE AND SIMPLE DESIGN, WITH A FORM AND A CONSTRUCTION THAT OPTIMIZES THE CAPACITY OF THE MATTRESS TO RESIST THE INFLATION AND IMPACT PRESSURES WHEN IT IS DEPLOYED. WHICH INCLUDES A SHEET (20) OF INTERLACED MATERIAL OF AT LEAST 420 THREADS, DEFINED BY AT LEAST ONE FOLDING LINE (22) AND A CERTAIN QUANTITY OF FINS PARTS (23), EACH PART OF FIN HAVE A EDGE OF BASE (24) CORRESPONDING TO THE FOLDING LINE (23) AND AT LEAST TWO SIDE EDGES (25) EACH OF WHICH PROLONGS OUTSIDE FROM THE EDGE OF THE BASE (24) AND FINALLY CONVERT UNTIL ONE WITH ANOTHER, WITH THE PARTS OF FINS FOLDED BY THE FOLDING LINES (22) AND JOINING BY THEIR CORRESPONDING SIDE EDGES ( ...

Liquid crystal cell and display having patterned electrode layer between at least cholesteric liquid crystal and electrode

A liquid crystal cell ( 5 ) comprises a layer ( 4 ) of cholesteric liquid crystal material; and a retarder ( 3 ) disposed in an optical path through the layer ( 4 ) of cholesteric liquid crystal material. The cholesteric liquid crystal material is switchable between a first state in which it cooperates with the retarder ( 3 ) to provide a first viewing angle range and a second state in which it cooperates with the retarder ( 3 ) to provide a second viewing angle range which is smaller than the first viewing angle range. The pitch of the cholesteric liquid crystal material is greater than an intended wavelength of operation of the liquid crystal cell divided by the average refractive index of the liquid crystal material. The liquid crystal cell may be used as a Viewing Angle Restriction (VAR) element, to enable another component, such as a display panel ( 6 ), to be operated in either a wide viewing mode or a narrow viewing mode.

Augmented reality system comprising light-emitting user input device

Selectively actuatable lighter

A selectively actuatable lighter device (10) is disclosed which includes a body (12) defining a reservoir for containing a combustible gaseous medium such as butane, and having a valve (20, 21) arranged to be selectively actuated between a normally closed position and an open position and a position which permits the exit of the gaseous medium. Such a lighter can selectively produce sparks at a location proximate to the gaseous medium exit to ignite the gaseous medium. Such lighter device embodies a resiliently releasable latch (16) which normally prevents actuation of a valve actuator (14) to the open position thereby preventing actuation of the valve. The latch is selectively movable to a position out of interference (Figure 14) with the valve actuator (14) so that the gaseous medium may be released and ignited by the sparks. The latch is resiliently structured and mounted such that once the flame is produced and the valve actuator is released, the latch returns to its closed or latched position.

NEW VECTOR OF ADENO-ASSOCIATED VIRUS (AAV) SUBTYPE F AND USES OF IT

Un vector de virus adenoasociado recombinante (rAAV), que comprende una capside de AAVhu68 producida en un sistema de produccion que comprende una secuencia de nucleotidos de la SEQ ID NO: 1, o una secuencia al menos 75 % identica a esta, que codifica la SEQ ID N0:2. La capside de AAVhu68 comprende subpoblaciones de residuos de asparagina muy desamidados en los pares de asparagina-glicina en la secuencia de aminoacidos de la SEQ ID NO: 2. Tambien se proporcionan composiciones que contienen el rAAV y usos de estas. Ademas, se proporcionan rAAV que tienen una capside de AAV modificada, que comprende al menos una subpoblacion de proteinas vp1 o vp2 con una Val en la posicion de aminoacidos 157, con referencia a la numeracion de vp1 de AAVhu68 A recombinant adeno-associated virus (rAAV) vector, comprising a capsid of AAVhu68 produced in a production system comprising a nucleotide sequence of SEQ ID NO: 1, or a sequence at least 75% identical to it, that encodes the SEQ ID N0: 2. The AAVhu68 capsid comprises subpopulations of highly deamidated asparagine residues in the asparagine-glycine pairs in the amino acid sequence of SEQ ID NO: 2. Compositions containing the rAAV and uses thereof are also provided. In addition, rAAVs having a modified AAV capsid are provided, comprising at least one subpopulation of vp1 or vp2 proteins with a Val at amino acid position 157, with reference to the vp1 numbering of AAVhu68

Utility lighter

An utility lighter including a housing having a handle at one end and a nozzle at another end and including a fuel supply connected for selective fluid communication with the nozzle. An ignitor assembly, such as a piezoelectric mechanism, is operatively connected to the housing for generating a spark proximate the nozzle and an actuating assembly is connected to the housing proximate the handle and operates to both dispense fuel from the fuel supply and to activate the ignitor assembly. A latch member is operatively connected with the handle and includes a blocking portion connected for biased movement relative to the actuating assembly. The latch member is normally biased into engagement with the actuating assembly to prevent operative movement except when the user moves the latch member against the bias. When the latch member is moved out of engagement with the actuating assembly by the user, a trigger may be pulled to release fuel and initiate a spark at the nozzle. In another aspect, the piezoelectric element includes a contact directly contacting an electrically conductive portion of the housing extending generally between the piezoelectric mechanism and the nozzle. A spark is thereby generated between the electrically conductive housing and the nozzle to ignite a flame.

Method and apparatus for converting address information between PCI bus protocol and a message-passing queue-oriented bus protocol

PCI load/store operations and DMA operations are implemented via work queue pairs in a message-passing, queue-oriented bus architecture. PCI address space is divided into segments and, each segment, in turn, is divided into regions. A separate work queue is assigned to each segment. A first portion of a PCI address is matched against the address ranges represented by the segments and used to select a memory segment and its corresponding work queue. An entry in the work queue holds a second portion of the PCI address which specifies a region within the selected segment that is assigned to a specific PCI device. In one embodiment, PIO load/store operations are implemented by selecting a work queue assigned to PIO operations and creating a work queue entry with the PCI address of a register on a PCI device and a pointer to the PIO data. The work queue entry is sent to a PCI bridge where the PCI address is extracted and used to program the appropriate device register with the data using the data pointer. DMA transfers are also implemented by selecting a work queue by means comparing a portion of the PCI address generated by the PCI device to an address range table and selecting a work queue that services the address range. A work queue entry is created with the remainder of the PCI address and a pointer to the DMA data. An RDMA operation is used to perform the DMA transfer. The page and region data is used in connection with a translation protection table in the host channel adapter to access physical memory and perform the DMA transfer.

COMPOSITIONS THAT INCLUDE ADENO-ASSOCIATED VIRUS (AAV) THAT EXPRESSES DUAL ANTIBODY CONSTRUCTS AND THEIR USES

Se describe un virus adenoasociado (AAV) recombinante que tiene una capside de AAV y empaquetado en ella un acido nucleico heterologo que expresa dos constructos de anticuerpos funcionales en una celula. Tambien se describen anticuerpos que comprenden una cadena pesada y una cadena ligera procedentes de un anticuerpo heterologo. En una realizacion, los anticuerpos se coexpresan a partir de un vector que contiene: un primer casete de expresion que codifica al menos un primer marco de lectura abierto (ORF) para una primera inmunoglobulina controlado por las secuencias de control reguladoras que dirigen su expresion; un segundo casete de expresion que comprende un segundo ORF, un conector y un tercer ORF controlados por secuencias de control reguladoras que dirigen su expresion, donde el segundo y el tercer ORF codifican para un segundo y un tercer constructo de inmunoglobulina; el vector que coexpresa estos dos constructos de anticuerpos es en una realizacion un AAV, en el cual las ITR de 5' y 3' flanquean los casetes de expresion y las secuencias reguladoras A recombinant adeno-associated virus (AAV) is described which has an AAV capsid and packaged therein a heterologous nucleic acid that expresses two functional antibody constructs in a cell. Also described are antibodies comprising a heavy chain and a light chain derived from a heterologous antibody. In one embodiment, the antibodies are co-expressed from a vector containing: a first expression cassette encoding at least a first open reading frame (ORF) for a first immunoglobulin controlled by regulatory control sequences that drive its expression; a second expression cassette comprising a second ORF, a linker and a third ORF controlled by regulatory control sequences that direct their expression, where the second and third ORF encode a second and a third immunoglobulin construct; the vector that co-expresses these two antibody constructs is in one embodiment an AAV, in which the 5 'and 3' ITRs ...

RECOMBINANT ADENO ASSOCIATED VIRUS FOR THE TREATMENT OF ADULT-ONSET NEURODEGENERATION ASSOCIATED WITH GRN

Se proporciona un régimen terapéutico útil para el tratamiento de la enfermedad neurodegenerativa de inicio en la edad adulta en un paciente humano que comprende la administración de un vector de virus adenoasociado recombinante (AAV) que tiene una cápside AAV1 y un genoma de vector que comprende una secuencia codificante de progranulina (GRN). También se proporcionan composiciones que comprenden un vector AAV recombinante y métodos para tratar la enfermedad neurodegenerativa de inicio en la edad adulta en un paciente que comprende la administración del vector AAV recombinante. A therapeutic regimen useful for the treatment of adult-onset neurodegenerative disease in a human patient is provided comprising administration of a recombinant adeno-associated virus (AAV) vector having an AAV1 capsid and a vector genome comprising a progranulin (GRN) coding sequence. Compositions comprising a recombinant AAV vector and methods of treating adult-onset neurodegenerative disease in a patient comprising administration of the recombinant AAV vector are also provided.

VERSATILE VIRAL VECTORS AND THEIR PRODUCTION SYSTEM

Insulated burner system for gas-fueled lighters

A burner assembly for gas-fueled lighters includes a metallic burn chamber rigidly connected to a fuel metering valve. The burner and fuel valve are rigidly connected through an insulated coupling component. This provides a more reliable structure and reduces heat transfer from the burner to the fuel source, reducing vapor lock conditions.

Utility lighter

An utility lighter having a housing (12) with a handle (14) proximate a first end (16), a nozzle (18) proximate a second end (20) and an electrically conductive housing portion (51) disposed between the first and second ends. The second end includes first and second electrodes (60, 64) forming a spark gap proximate the nozzle. The first electrode is formed by the electrically conductive housing portion. An electric ignitor assembly (34) is connected to the housing for generating a spark. The ignitor assembly generates a voltage between first and second electrical contacts (48, 50) thereof. The first electrical contact is in contact with the electrically conductive housing portion and the second contact is electrically connected to the second electrode. An actuating assembly (38) is connected to the housing and dispenses fuel from a fuel supply (22) and activates the ignitor assembly.

ABE ADENOVIRUS WITH SADV-46 HEXONCAPSIDE PROTEINS AND APPLICATIONS THEREOF

Methods for expression of genes in primates

Methods for high level expression of genes in primates are disclosed. Such methods involve expression of transgenes comprising an RSV promoter and a nucleic acid sequence that is heterologous thereto.

Amphibian steering mechanism

Transduced fibroblasts and use therefor

Insulated burner system for gas-fueled lighters

A burner assembly for gas-fueled lighters includes a metallic burn chamber rigidly connected to a fuel metering valve. The burner and fuel valve are rigidly connected through an insulated coupling component. This provides a more reliable structure and reduces heat transfer from the burner to the fuel source, reducing vapor lock conditions.

IMPROVED ADENOVIRUS AND METHODS FOR THEIR USE

Utility lighter

Recovery of sulfur dioxide from gas mixtures

ABSTRACT OF THE DISCLOSURE Ammonia is added to aqueous scrubbing solution contain-ing an organic base-sulfurous acid reaction product, preferably an aromatic amine-sulfurous acid reaction product, an organic base-sulfuric acid reaction product, preferably an aromatic amine-sulfuric acid reaction product and water in a separating zone located exteriorly of an absorption tower. The aqueous scrubbing solution is obtained from a sulfurous acid solution scrubbing sec-tion of the absorption tower wherein an organic base, preferably an aromatic amine, is utilized as absorbent in a lower absorber section of the tower to remove SO2 from a SO2-containing gas mix-ture, followed by scrubbing the SO2-depleted, aromatic amine-en-riched effluent gas from the absorber section with sulfurous acid-and ammonium sulfate-containing aqueous solution in the upper sulfurous acid scrubbing section of the tower to remove sub-stantially all of the gaseous aromatic amine from the gas. The sulfur dioxide-impoverished, substantially organic base absorbent-free effluent gas from the sulfurous acid scrubbing zone is dis-charged from this scrubbing zone and ultimately to the atmosphere without any additional scrubbing of this effluent gas, after its discharge from such scrubbing zone, with sulfuric acid solution or any other acid solution or any acid. The sulfur dioxide is strip-ped from the pregnant aromatic amine absorbent from the absorbing section in the stripping section of a stripping tower. The am-monia treatment of the aqueous scrubbing solution in the external separating zone results in release of the aromatic amine from the aromatic amine-sulfuric acid reaction product present therein by reaction of the ammonia with the aromatic amine-sulfuric acid reaction product and also in the formation of ammonium sulfate. An aqueous liquid solution containing the ammonium sulfate and the aromatic amine-sulfurous acid reaction product separates as a lower layer from the released aromatic amine ...

Passive header module for a modular energy system

A modular energy system including a header module and a module. The header module includes a display screen for displaying a user interface. The header module is configured to receive data, including safety critical data, from the module, control the display screen to cause the Ul to display Ul content based on the received data, the Ul content including safety critical Ul content based on the safety critical data, and transmit the displayed safety critical Ul content to the module for verification thereby. The module is configured to confirm whether the transmitted safety critical data coincides with the displayed safety critical Ul content. In the event that it is determined that they do not coincide, the header module and/or the module can be configured to stop the function(s) of the module, display an alert on the display screen, and take various other actions.

Simian subfamily and adenovirus sadv-39, -25.2, -26, -30, -37 and -38 and uses thereof.

Recombinant adenovirus, isolated host cell containing it, composition comprising the recombinant adenovirus and use

Det beskrives en rekombinant vektor omfattende simianadenovirussekvenser og heterologt gen under kontroll av regulatoriske sekvenser. Det beskrives videre en cellelinje som uttrykker ett eller flere simianadenovirusgener. Det beskrives fremgangsmåter for anvendelse av vektorene og cellelinjene.

Lighter device with flow restrictor and methods of manufacturing and testing same

A lighter device having a flow restrictor and associated methods for manufacturing and testing such lighter device and flow restrictor are described. The flow restrictor may be formed of a porous member to achieve a substantially fixed or varying flame height. The flow restrictor may be tested before or after assembly into a lighter housing by receiving a non-combustible fluid therethrough. The flow rate of the non-combustible fluid may be correlated to the flow rate of a combustible fluid through the flow restrictor to approximate the resultant flame height of a lighter incorporating the tested flow restrictor. The flow restrictor may also be tested by receiving a combustible fluid therethrough prior to assembling the flow restrictor into the lighter housing. In this manner, flow restrictors and corresponding lighter devices may be tested without introducing combustible fluids into such lighter devices prior to shipment. Also, a vacuum may be drawn on a fuel tank of the lighter prior to shipment.

Wringer.

Multiple stage tractor propulsion vehicle

A multiple stage orbital delivery vehicle that uses tractor propulsion to launch the vehicle into space. Only the upper stage of the vehicle includes an engine and avionics allowing the lower stages to be only liquid propellant tanks that may be dumped when empty. The liquid propellant may be either monopropellant or bi-propellant. The upper stage may include multiple nozzles that burn the propellant. Alternatively, the upper stage may include an aerospike engine instead of nozzles. The multiple stage orbital delivery vehicle may be air launched from an airborne aircraft or may be launched from the ground.

Lighter with looped guard

Oil burner

Fire-escape.

A liquid crystal cell and a display

A liquid crystal cell (5) comprises a layer (4) of cholesteric liquid crystal material; and a retarder (3) disposed in an optical path through the layer (4) of cholesteric liquid crystal material. The cholesteric liquid crystal material is switchable between a first state in which it cooperates with the retarder (3) to provide a first viewing angle range and a second state in which it cooperates with the retarder (3) to provide a second viewing angle range which is smaller than the first viewing angle range. The pitch of the cholesteric liquid crystal material is greater than an intended wavelength of operation of the liquid crystal cell divided by the average refractive index of the liquid crystal material. The liquid crystal cell may be used as a Viewing Angle Restriction (VAR) element, to enable another component, such as a display panel (6), to be operated in either a wide viewing mode or a narrow viewing mode.

Quick pixel rendering processing

A three-dimensional (3D) graphics pipeline which processes pixels of sub-screens in the last stage (pixel rendering) in parallel and independently. The sub-screen tasks are stored in a list in a shared memory. The shared memory is accessed by a plurality of processing threads designated for pixel rendering. The processing threads seize and lock sub-screens tasks in an orderly manner and process the tasks to create the bit map for display on a screen. The tasks are created by dividing a display area having the vertex information superimposed thereon into M×N sub-screen tasks. Based on system profiling, M and N may be varied.

Contextual awareness of user interface menus

Systems and methods for a wearable system to automatically select or filter available user interface interactions or virtual objects are disclosed. The wearable system can select a group of virtual objects (1210, 1220) for user interaction based on contextual information associated with the orientation of a physical object (1242, 1246).

Multi-purpose tool and tension mechanism

MULTI-PURPOSE TOOL AND TENSION MECHANISM A tool (10) is provided. The tool (10) may include a handle (12), a frame (11), and a removable saw blade (13) including at least one hole (24) on one end thereof and at least one hole (23) on another end thereof. The tool (10) may also include a compensating clip (20) configured to attach the removable saw blade (13) to the frame (11) and to provide tension for the removable saw blade (13). The compensating clip (20) may include a plate (29) including a clip hook (28), and the plate (29) further includes an opening (26) where a compensator spring (27) is provided. The clip hook (28) is configured to attach onto the at least one hole (23) of the removable saw blade (13) to attach the saw blade (13) to the frame (11). 'JI ~ -ii V~N~ (A

Non-combustible reinforced cementitious lightweight panels and metal frame system for shear walls

Modified adenovirus hexon protein and uses thereof

Air purifying device

The present invention provides an air purifying system which both filters and neutralizes odors in the air. A housing includes an inlet, an outlet, and an internal flow path from the inlet to the outlet. The outlet is preferably configured to provide a conical exhaust flow path. Fan means are located within the housing to move air through the housing along the flow path and out of the housing through the outlet. A filter is interposed in and spans the flow path of the housing to filter particulate matter from the air passing through the housing. An odor neutralizing chamber within the housing is partially interposed in the flow path. The chamber contains an odor neutralizing chemical which vaporizes in the presence of air. A mechanism is provided for controlling the amount of odor neutralizing chemical vapor which enters the air flowing through the housing.

COMPOSITIONS USEFUL TO TREAT GANGLIOSIDOSIS GM1

Se proporciona un esquema terapéutico útil para el tratamiento de gangliosidosis GM1 que comprende la administración de un vector de virus adenoasociado recombinante (rAAV) que tiene una cápside de AAV y un genoma de vector que comprende una secuencia que codifica a la b-galactosida humana. También se proporcionan composiciones que contienen un vector de rAAV y métodos para tratar gangliosidosis GM1 en pacientes que comprenden la administración de un vector de rAAV. A useful therapeutic scheme for the treatment of GM1 gangliosidosis is provided which comprises the administration of a recombinant adeno-associated virus (rAAV) vector having an AAV capsid and a vector genome comprising a sequence encoding human b-galactoside. Compositions containing a rAAV vector and methods of treating GM1 gangliosidosis in patients comprising administration of a rAAV vector are also provided.

Lubricating system for vertical pump shafts

Recombinant adeno-associated virus for the treatment of grn-associated adult-onset neurodegeneration

Se proporciona un AAV recombinante (rAAV) adecuado para su uso en el tratamiento de la neurodegeneración de inicio en adultos causada por la haploinsuficiencia de granulina (GRN), tal como la demencia frontotemporal (FTD) relacionada con progranulina (PGRN). El rAAV comprende (a) una cápside del virus adenoasociado 1, y (b) un genoma del vector empaquetado en la cápside de AAV, en donde dicho genoma del vector comprende repeticiones terminales invertidas de AAV, una secuencia codificante para progranulina humana y secuencias reguladoras que dirigen la expresión de la progranulina. También se proporciona un método para tratar a un paciente humano con PGRN-FTD y otra neurodegeneración de inicio en adultos causada por haploinsuficiencias de granulina (GRN), que comprende administrar al sistema nervioso central (SNC) un virus adenoasociado recombinante (rAAV) que tiene una cápside del virus adenoasociado 1 (AAV1), en donde dicho rAAV comprende además un genoma del vector empaquetado en la cápside de AAV, en donde dicho genoma del vector comprende repeticiones terminales invertidas de AAV, una secuencia codificante para progranulina humana y secuencias reguladoras que dirigen la expresión de la progranulina.

Anxiolytic agents with reduced sedative and ataxic effects

Orally active benzodiazepine derivatives and their salts are disclosed. These compounds and their salts have anxiolytic and anticonvulsant activity with reduced sedative/hypnotic/muscle relaxant/ataxic effects. Compounds of e.g. the following formula (I) are disclosed, wherein Y and Z are taken together with the two intervening carbon atoms to form a ring selected from phenyl and thienyl, which ring is substituted at the C(7) position with at least the substituent -C≡C-R where R is H, Si (CH3)3, t-butyl, isopropyl, methyl, or cyclopropyl; R1 is one of H, CH3, C2H4N (C2H5)2, CH2CF3, CH2CCH, or an alkyl cyclopropyl; R2 is a substituted or unsubstituted at least partially unsaturated 5 or 6 membered cyclic or heterocyclic ring, wherein if substituted the substituent is one or more of F, Cl, Br, or NO2 at the 2’ - position; R3 is one of H, OH, OCON(CH3)2, COOCH3, or COOC2H5.

Nanocomposite and method of making the same

A composition comprising exfoliated silicate platelets; a thermoplastic polymer; and a block copolymer and method of making the same.

Programmable controller for controlling reproduction machines

ABSTRACT OF THE DISCLOSURE A programmable controller is used to control the operation of a xerographic reproducing machine adapted to run in a simplex or duplex mode whereby copies are made on either or both sides of web material fed in a single pass and then cut into individual copy sheets.

Commutation board for brushless motor

A board for commutation of a brushless motor having an encoder comprising a plurality of Hall-effect sensors operative for providing commutation information to a motor controller including an output drive section which comprises three high-side power FET's and three low-side power FET's connected to determined stator windings of the brushless motor. A low-side pre-drive circuit is operative to selectively turn on each of the low-side FETs and a high-side pre-drive circuit is operative to selectively turn on each of the high-side FETs. A commutation decode logic circuit is connected to the Hall-effect sensors to receive the commutation position information from the Hall-effect sensors and is connected to the high-side and low-side pre-drive circuits for providing selection signals for selecting the appropriate power FETs for commutating the motor. The board is preferably affixed to the end of the brushless motor. The board may further comprise an overcurrent monitoring and disabling circuit as well as a temperature measurement circuit for measuring the temperature of the board.

Selecting virtual objects in a three-dimensional space

Thermoplastic resins for network applications

The present disclosure relates to the use of thermoplastic resins in millimeter wave network applications. More specifically, it relates to polyamide materials meeting the requirements of dielectric performance in such applications.

Modified adenovirus hexon protein and uses thereof