Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors

This invention discloses novel gamma secretase inhibitors of the formula: R 2 and R 3 , or R 2 and R 4 , or R 3 and R 4 , together with the atoms to which they are bound, can form a fused cycloalkyl or fused heterocycloalkyl ring. The cycloalkyl ring or the heterocycloalkyl ring can be optionally substituted with one or more substituents. One or more compounds of formula (I), or formulations comprising such compounds, may be useful, e.g. in treating Alzheimer's Disease.

Method and Apparatus for Coordinating a Change in Service Provider Between a Client and a Server with Identity Based Service Access Management

A method of configuring a network access device connected to an access network connected to a plurality of service networks, the network device having a first network address allocated to a subscriber of services of a first service provider provided by a first service network, with a new network address allocated to a second subscriber of services of either the first service provider, or a second service provider provided by a second service network. The method comprises the steps of: sending a request from the network access device to the access network with user credentials for the second subscriber requesting access to the first service provider or a change to the second service provider; receiving a response from the access network; and initiating a network address change request using a configuration protocol. In this manner, a second network address allocated to the second subscriber of services of either the first or second service providers is assigned to the network access device to enable the network access device to communicate data packets to the service network providing the selected service.

Efficient short message compression

A method for compressing a short message includes receiving a short message that includes a plurality of text strings for compression, dividing the short message into one or more sub-blocks, where a number of text strings in each of the one or more sub-blocks is less than or equal to a predetermined number. The method also includes compressing each of the one or more sub-blocks by identifying a type of a first text string, identifying a code representing the type, determining whether the first text string exists in a library, upon determining that the first text string exists in the library, determining an index corresponding to the first text string, extracting a predetermined number of least significant digits of the index, and replacing the first text string in that sub-block with the code and the extracted predetermined number of least significant digits of the index.

Poppet valve with a frangible sealing disc for a pressure vessel

A valve assembly for a pressure vessel is disclosed that includes a valve housing operatively associated with an outlet of the pressure vessel, a frangible hermetic disc sealing the outlet of the pressure vessel, and a poppet valve mounted for movement within the valve housing between a first position supporting the frangible hermetic disc within the outlet of the pressure vessel and a second position spaced apart from the frangible hermetic disc to permit the frangible disc to burst under pressure and permit the egress of pressurized material from the pressure vessel through the outlet.

Mobile computing device charging and networking system and method

Systems and methods for charging and/or networking mobile computing devices. A cart for storing, charging, and/or networking mobile computing devices. A portable interface between a mobile computing device and a cart. A docking station module having a plurality of docking stations.

Add-on wrap-around dashboard

The invention disclosed here is a dashboard accessory item in the form of an add-on housing that enables the repositioning of certain instrument panels closer to the driver, thereby making the instruments on such panels more accessible. In use, the instrument panels are first detached from a stock dashboard, and the housing is mounted to the dashboard over the location where the panels were originally located. The add-on housing projects forwardly of the dashboard, and the panels are remounted to its forward or frontal face. Such face angles toward the driver as it extends along the dashboard from the steering wheel toward the right-hand side of the cab. This repositions the panels much closer to the driver than they were when originally mounted to the stock dashboard.

Add-on wrap-around dashboard

The invention disclosed here is a dashboard accessory item in the form of an add-on housing that enables the repositioning of certain instrument panels closer to the driver, thereby making the instruments on such panels more accessible. In use, the instrument panels are first detached from a stock dashboard, and the housing is mounted to the dashboard over the location where the panels were originally located. The add-on housing projects forwardly of the dashboard, and the panels are remounted to its forward or frontal face. Such face angles toward the driver as it extends along the dashboard from the steering wheel toward the right-hand side of the cab. This repositions the panels much closer to the driver than they were when originally mounted to the stock dashboard.

Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof

Novel compounds of formula (I) wherein A is -CH=CH-B; -C=C-B; -(CH2?)p?-X-B, wherein p is 0-2 and X is a bond, -NH- or -S(O)0-2?-; optionally substituted heteroaryl or benzofused heteroaryl; -C(O)-B; or (Ia), wherein k is 1-2; D is B'-(CH2?)m?C(O)-, wherein m is 1-5; B'-(CH2?)q?-, wherein q is 2-6; B'-(CH2?)e?-Z-(CH2?)r?-, wherein Z is -O-, -C(O)-, phenylene, -NR8?- or -S(O)0-2?-, e is 0-5 and r is 1-5, provided that the sum of e and r is 1-6; B'-(alkenylene)-; B'-(alkadienylene)-; B'-(CH2?)t?-Z-(alkenylene), wherein t is 0-3, provided that the sum of t and the number of carbon atoms in the alkenylene chain is 2-6; B'-(CH2?)f?-V-(CH2?)g?-, wherein V is cycloalkylene, f is 1-5 and g is 0-5, provided that the sum of f and g is 1-6; B'-(CH2?)t?-V-(alkenylene) or B'-(alkenylene)-V-(CH2?)t?-, provided that the sum of t and the number of carbon atoms in the alkenylene chain is 2-6; B'-(CH2?)a?-Z-(CH2?)b?-V-(CH2?)d?-, wherein a, b and d are 0-6, provided that the sum of a, b and d is 0-6; T-(CH2?)s?-, wherein T is cycloalkyl and s is 1-6; naphthylmethyl or optionally substituted heteroarylmethyl; B is optionally substituted phenyl; B' is naphthyl, optionally substituted heteroaryl or optionally substituted phenyl; R is hydrogen, fluoro, alkyl, alkenyl, alkynyl, or B-(CH2?)h?-, wherein h is 0-3; R4? is optionally substituted phenyl, indanyl, benzofuranyl, tetrahydronaphthyl, pyridyl, pyrazinyl, pyrimidinyl or quinolyl; are disclosed, as well as their use as hypocholesterolemic agents; the method of using compounds of formula (II), wherein R20? is optionally substituted phenyl, optionally substituted naphthyl, optionally substituted heteroaryl, or optionally substituted benzofused heteroaryl, R21?, R22? and R23? are independently selected from H or R20?; E, F and G are independently a bond; cycloalkylene; alkylene; alkenylene; alkynylene; a substituted alkylene, alkenylene or alkynylene chain; an interrupted alkylene, alkenylene or ...

Substituted n-[(pyridyl)alkyl]aryl-carboxamide

The invention relates to compounds of the formula ##STR1## wherein *B is ##STR2## Y is O or S, *A is *--(CH 2 ) n --(X) m --(CH 2 ) r --, n or r, independently, are integers from 0 to 3, m is an integer from 0 to 1, provided that when m is 1, then n must be at least 1, X is O or S, R 1 and R 4 , independently, are hydrogen, lower alkyl, hydroxy or lower alkoxy, provided that when *B is other than ##STR3## at least one of R 1 and R 4 , and one of R 6 and R 7 must be hydrogen, R 2 and R 3 are independently hydrogen, lower alkyl, cycloalkyl, halogen, nitro, lower alkoxy, lower alkenyl, lower alkynyl or aryl, R 5 and R 6 , independently are hydrogen or lower alkyl, R 7 is hydrogen, lower alkyl, cycloalkyl or aryl, Het is a monocyclic 5- or 6-membered hetero aromatic or a bicyclic heteroaromatic radical containing one or two hetero atoms selected from nitrogen oxygen and sulfur, which radical may be substituted by lower alkyl, halogen or aryl, and the asterisk denotes the point of attachment, and when R 6 and R 7 are different, their enantiomers and racemic mixtures thereof, and pharmaceutical acceptable acid addition salts thereof. The compounds of formula I exhibit activity as Platelet Activating Factor (PAF) antagonists and are, therefore, useful as agents for the prevention and treatment of vascular diseases, pulmonary diseases, dermatological disorders, transplant rejection, immunological disorders and inflammatory conditions.

Vessel retractor

A surgical apparatus includes an elongate cannula having a lumen extending therein between proximal and distal ends, a retractor disposed to slide within the lumen to extend a distal end thereof beyond the distal end of the cannula, an angling device connected to the retractor near the distal end of the retractor and extending within the cannula toward the proximal end thereof for selectively deflecting the distal end of the retractor away from a central axis of the cannula in response to manual manipulation of the angling device from near the proximal end of the cannula, wherein the distal end of the retractor is configured to move, upon extension, an object away from the central axis of the cannula.

Organic electroluminescent materials and devices

A compound comprising a ligand L A according to formula (I) as well as, a first device and a formulation including the same are disclosed. In the structure of formula (I): ring A is a 5- or 6-membered heteroaryl ring; X 1 is C or N; R A is mono-, bi-, tri-, tetradentate, or unsubstituted; R A , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , and R 17 are independently selected from the group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof, any adjacent substituents of R A , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , and R 17 are optionally joined to form a fused ring; the dashed lines represent bonds to a metal M; and metal M has an atomic number greater than 40.

Dehydrating process for starchy vegetables, fruits, and the like

Insulated roof panel

A composite roof panel comprising inner and outer skins which are connected in shear-transferring relation by an insulating core. The outer skin presents marginal connecting means, a first of which is adapted to receive and to be bent, i.e., closed, about a second connecting means of an adjacent panel to provide a standing seam connection at the exterior face of the roof structure. During closure, the first connecting means is bent in one direction and experiences only minor bending stresses. Hence, a large number of different types of decorative coating materials can be applied to the outer skin. The inner skin presents complementary mating elements which provide a connection between adjacent panels at the interior face of the roof structure. Means adapting the panel to be erected in end-to-end overlapped relation and in side-by-side interlocked relation is disclosed.

Roof panel joint

A joint between roof panels of the type comprising inner and outer skins connected in shear-transferring relation by an insulating core. The joint comprises male and female marginal connecting means formed along the upper edges of adjacent side walls presented by the outer skins of adjacent panels. The male and female connecting means are inter-nested, the female connecting means is bent, that is, closed about the male connecting means thereby to provide a primary interlocking connection of the standing seam type. A sealant engaging the male and female connecting means provides a primary weathertight seal at the exposed surface of the roof structure. Complementary mating elements may be formed along adjacent inner edges of the adjacent composite panels to provide a second connection at the interior face of the roof structure.

Poppet valve with a frangible sealing disc for a pressure vessel

System and method for building and validating a credit scoring function

This invention relates generally to the personal finance and banking field, and inore particularly to the field of credit scoring methods and syste1ns. Preferred embodiinents of the present invention provide systems and methods for building and validating a credit scoring function based on a creditor's target inforn1ation from non-traditional sources using specific algorithms.

Systems and methods for type coercion

Systems and methods for converting a data item provided by an external data provider system into a data type specified by a data processing system for a data field of the data item. A data processing system stores a coercion rule for each data field of a first data set provided by the data provider system. Each stored coercion rule identifies at least one data type for the corresponding data field. Responsive to a second data set provided by the data provider system, the data processing system coerces each data item of the second data set into at least one data type specified by the stored coercion rule for the data field of the data item to generate at least one converted data item of the second data set. The data processing system generates information from at least one converted data item, and provides the information to a consuming system.

API for implementing scoring functions

This invention relates generally to data assembly and analytics, as can be used in the personal finance and banking field, and more particularly to the field of lending and credit notification methods and systems. Preferred embodiments of the present invention provide systems and methods for creating objects which can be used in multiple implementations to generate scores.

API for implementing scoring functions

This invention relates generally to data assembly and analytics, as can be used in the personal finance and banking field, and more particularly to the field of lending and credit notification methods and systems. Preferred embodiments of the present invention provide systems and methods for creating objects which can be used in multiple implementations to generate scores.

Systems and methods for type coercion

Systems and methods for converting a data item provided by an external data provider system into a data type specified by a data processing system for a data field of the data item. A data processing system stores a coercion rule for each data field of a first data set provided by the data provider system. Each stored coercion rule identifies at least one data type for the corresponding data field. Responsive to a second data set provided by the data provider system, the data processing system coerces each data item of the second data set into at least one data type specified by the stored coercion rule for the data field of the data item to generate at least one converted data item of the second data set. The data processing system generates information from at least one converted data item, and provides the information to a consuming system.

Selective hydrolysis of lignocellulose materials

Ion-sensitive compounds

Ion-sensitive compounds are provided comprising a quaternary polypyridinium receptor designed to bind anionic species by the formation of a receptor-substrate complex. The receptor comprises one or more quaternary 2,2'-bipyridyl moieties. The compounds are of use in applications requiring anion detection or removal.

Food tray with cover

Implant retaining device

There is provided an implant retianing device, which has the effect of preventing an intervertebral implant form jutting out of hte receiving bed. The implant retaining device generally includes a plate having at least one throughbore to recive a screw, and a screw for securing the plate to the vertebrae. The plate may be dinensioned to cover a poriton of the opening of a receiving bed, and thus, need only be secured to a single vertebral body. In an alternate embodiemnt, the plate may be used during bone fracture correction procedures to prevent a bone screw form backing out of engagement with adjacent bone sections. A method of retaining an intervertebral implant using the device is also provided.

Quick break electric switches

Light reflector

Mch antagonists and their use in the treatment of obesity

The present invention discloses compounds of the formula (I) which are novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.

DISCHARGE LAMP HAVING A CAPACIALLY CAPACITIVE INITIATION DEVICE CONNECTED TO AN ELECTRODES

LA LAMPE A DECHARGE, SELON L'INVENTION, COMPREND UNE AMPOULE TUBULAIRE EN VERRE 12 POURVUE A CHACUNE DE SES EXTREMITES D'UNE ELECTRODE PRENANT APPUI SUR DEUX ENTREES DE COURANT 20, 22 ET 21, 23 SCELLEES DANS LE PIED CORRESPONDANT 16, 18. LA PAROI INTERNE DE LA LAMPE EST RECOUVERTE D'UNE COUCHE DE LUMINOPHORES 14. UNE TROISIEME ENTREE DE COURANT 28, ADJACENTE A L'UNE DES ELECTRODES EST INDIFFEREMMENT PLACEE A L'UNE DES EXTREMITES DE LA LAMPE. L'EXTREMITE INTERNE DE CETTE TROISIEME ENTREE DE COURANT EST RELIEE A UN FIL D'AMORCAGE 30 ASSEZ RESISTANT, TRAVERSANT LE CORPS DE LA LAMPE DANS SA LONGUEUR JUSQU'A PROXIMITE IMMEDIATE DE L'AUTRE ELECTRODE. L'ENSEMBLE EST COMPLETE PAR UN CIRCUIT BALLAST RESISTIF QUI RELIE EN SERIE LES ELECTRODES 24, 26 DE LA LAMPE ET LE FIL D'AMORCAGE 30 DE CETTE DERNIERE. DES MOYENS 44 SONT PREVUS POUR RELIER CAPACITIVEMENT LA TROISIEME ENTREE DE COURANT 28 ET, PAR SUITE, LE FIL D'AMORCAGE 30 A L'UNE DES ENTREES DE COURANT DE SON ELECTRODE VOISINE. APPLICATION A L'ECLAIRAGE. THE DISCHARGE LAMP, ACCORDING TO THE INVENTION, INCLUDES A TUBULAR GLASS BULB 12 PROVIDED AT EACH OF ITS ENDS WITH AN ELECTRODE BASED ON TWO CURRENT INPUTS 20, 22 AND 21, 23 SEALED IN THE CORRESPONDING FOOT 16, 18. THE INTERNAL WALL OF THE LAMP IS COVERED WITH A LAYER OF LUMINOPHORES 14. A THIRD CURRENT INPUT 28 ADJACENT TO ONE OF THE ELECTRODES IS INDIFFERENTLY LOCATED AT ONE OF THE ENDS OF THE LAMP. THE INTERNAL END OF THIS THIRD CURRENT INPUT IS CONNECTED TO A RIGHTLY STRONG 30 STARTING WIRE, THROUGH THE BODY OF THE LAMP IN ITS LENGTH UP TO IMMEDIATE PROXIMITY OF THE OTHER ELECTRODE. THE ASSEMBLY IS COMPLETED BY A RESISTIVE BALLAST CIRCUIT WHICH CONNECTS IN SERIES THE ELECTRODES 24, 26 OF THE LAMP AND THE STARTING WIRE 30 OF THE LATTER. MEANS 44 ARE PROVIDED TO CAPACITIVELY CONNECT THE THIRD CURRENT INPUT 28 AND, THEREFORE, THE PRIMER WIRE 30 TO ONE OF THE CURRENT INPUTS OF ITS NEIGHBORING ELECTRODE. APPLICATION TO ...

STAND WITH THREE CURRENT INPUTS FOR DISCHARGE LAMP WITH INTERNAL STARTING DEVICE

L'INVENTION CONCERNE LES PIEDS DES LAMPES A DECHARGE COMPRENANT UNE AMPOULE TUBULAIRE EN VERRE SUR LA SURFACE INTERNE DE LAQUELLE EST DISPOSEE UNE COUCHE DE LUMINOPHORES. L'UN DES PIEDS DE L'AMPOULE 18 COMPORTE UNE TROISIEME ENTREE DE COURANT 28, A L'EXTREMITE INTERNE DE LAQUELLE EST CONNECTE UN FIL D'AMORCAGE 30 S'ETENDANT SUR UNE LONGUEUR SENSIBLEMENT EGALE A CELLE DE L'ARC. CETTE TROISIEME ENTREE DE COURANT 28 EST PRESQUE PARALLELE A L'AXE LONGITUDINAL DU PIED, L'EXTREMITE DU FIL D'AMORCAGE 30 A LAQUELLE ELLE EST CONNECTEE ETANT, SUR UNE COURTE DISTANCE, PERPENDICULAIRE A CET AXE LONGITUDINAL ET LE RESTE DU FIL ETANT SENSIBLEMENT PARALLELE A CET AXE. APPLICATION A L'ECLAIRAGE. THE INVENTION CONCERNS THE FEET OF DISCHARGE LAMPS INCLUDING A TUBULAR GLASS BULB ON THE INTERNAL SURFACE OF WHICH A LAYER OF LUMINOPHORES IS PROVIDED. ONE OF THE FEET OF BULB 18 CONTAINS A THIRD CURRENT INPUT 28, AT THE INTERNAL END OF WHICH IS CONNECTED A PRIMER WIRE 30 EXTENDING A LENGTH SENSITIVELY EQUAL TO THAT OF THE ARC. THIS THIRD CURRENT INPUT 28 IS ALMOST PARALLEL TO THE LONGITUDINAL AXIS OF THE FOOT, THE END OF THE PRIMER WIRE 30 TO WHICH IT IS CONNECTED BEING, FOR A SHORT DISTANCE, PERPENDICULAR TO THIS LONGITUDINAL AXIS AND THE REMAINDER OF THE WIRE IS SENSITIVE. PARALLEL TO THIS AXIS. APPLICATION TO LIGHTING.

Mch antagonists and their use in the treatment of obesity

The present invention discloses compounds of the formula (I) which are novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonists as well as metho ds of using them to treat obesity, metabolic disorders, eating disorders such a s hyperphagia, and diabetes.

JOINT SYSTEM BETWEEN ROOF PANELS

La présente invention concerne un système de joint entre panneaux de toiture adjacents du type comportant des parois externe 11 et interne 12 espacées lune de l'autre et une âme isolante 13 qui solidarise la paroi externe il et la paroi interne 12 en transférant les forces de cisaillement. Le joint comporte des nervures interne et externe 24, 28 de forme générale tubulaire prévues le long des bords supérieurs des première et seconde parois latérales 22, 23 en saillie qui sont formées le long des bords longitudinaux adjacents des parois externes la nervure interne présentant une ouverture longitudinale entre le flasque terminal de la nervure interne et le bord supérieur de la première paroi latérale et la nervure externe présentant une bande terminale repliée vers l'intérieur qui est engagée autour du bord terminal et se prolonge à l'intérieur de la nervure interne pour bloquer la nervure externe sur la nervure interne. Un matériau d'etanchéité 32 est engagé entre les nervures interne et externe. Ce joint est étanche aux intempéries et à la vapeur. The present invention relates to a joint system between adjacent roof panels of the type comprising outer 11 and inner 12 walls spaced apart one from the other and an insulating core 13 which secures the outer wall 11 and the inner wall 12 by transferring the forces of shear. The seal has inner and outer ribs 24, 28 of generally tubular shape provided along the upper edges of the first and second projecting side walls 22, 23 which are formed along the adjacent longitudinal edges of the outer walls with the inner rib having an opening longitudinal between the end flange of the inner rib and the upper edge of the first side wall and the outer rib having an inwardly folded end band which is engaged around the end edge and extends inside the inner rib to block the outer rib on the inner rib. A sealing material 32 is engaged between the inner and outer ribs. This seal is weatherproof and vapor tight.

ROOF INSULATION PANELS

La présente invention concerne des panneaux de toiture isolants comprenant une paroi externe, une paroi interne et un noyau isolant qui connecte la paroi interne à la paroi externe. La paroi interne 12 comporte une âme centrale 32 et des éléments à emboîtement mutuel complémentaires 18,19 réalisés le long de ses bords longitudinaux opposés. La paroi externe il comporte une âme centrale 21 présentant des première et seconde parois latérales verticales 22, 23 se prolongeant vers le haut à partir du bord longitudinal opposé de l'âme externe, et des premier et second moyens de connexion 16,17 réalisés le long du bord supérieur des première et seconde parois latérales 22, 23. Les panneaux de la présente invention fournissent une structure de toiture étanche à l'eau et isolée thermiquement et phoniquement. The present invention relates to insulating roof panels comprising an outer wall, an inner wall, and an insulating core that connects the inner wall to the outer wall. The internal wall 12 comprises a central core 32 and complementary mutually interlocking elements 18,19 made along its opposite longitudinal edges. The outer wall comprises a central core 21 having first and second vertical side walls 22, 23 extending upwards from the opposite longitudinal edge of the outer core, and first and second connection means 16,17 made on the along the top edge of the first and second side walls 22, 23. The panels of the present invention provide a waterproof, heat and sound insulated roof structure.

GRIPPER BAR FOR FINGERS FOR SINGLE USE INJECTION SYRINGES

Barrette de préhension (appui-doigts) pour des seringues comprenant un cylindre à une extrémité duquel la barrette en matière plastique peut être fixée après remplissage du cylindre, cette barrette présentant un appui 1 en forme de platine avec une partie d'emboîtement 2 dont le diamètre extérieur est inférieur au diamètre intérieur du cylindre et sur laquelle sont formés des éléments d'enclenchement 3 pour l'assemblage avec le cylindre présentant une contre-dépouille intérieure complémentaire, une bague de blocage 4 pouvant être insérée à l'intérieur de la partie d'emboîtement 2. La bague 4 est reliée à la partie 2 par des emplacements de rupture et peut être amenée en position de blocage lors de l'emboîtement du cylindre sur la partie 2, qui n'est formée que de segments périphériques, les éléments 3 pour l'assemblage avec le cylindre étant formés dans les intervalles entre lesdits segments. Gripping bar (finger rest) for syringes comprising a cylinder at one end of which the plastic bar can be fixed after filling the cylinder, this bar having a support 1 in the form of a platinum with an interlocking part 2, the external diameter is less than the internal diameter of the cylinder and on which are formed engagement elements 3 for assembly with the cylinder having an additional internal undercut, a locking ring 4 can be inserted inside the part 2. The ring 4 is connected to part 2 by break locations and can be brought into the locking position when the cylinder fits on part 2, which is formed only by peripheral segments, the elements 3 for assembly with the cylinder being formed in the intervals between said segments.

Roof panel joint

ABSTRACT A joint between roof panels of the type comprising inner and outer skins connected in shear-transferring relation by an insulating core. The joint comprises male and female marginal connecting means formed along the upper edges of adjacent side walls presented by the outer skins of adjacent panels. The male and female connecting means are inter-nested, the female connecting means is bent, that is, closed about the male connecting means thereby to provide a primary interlocking connection of the standing seam type. A sealant engaging the male and female connecting means provides a primary weathertight seal at the exposed surface of the roof structure. Complementary mating elements may be formed along adjacent inner edges of the adjacent composite panels to provide a second connection at the interior face of the roof structure.

Method for strengthening glass

Portable communications device with demodulation correction and related methods

A portable communications device communicates based upon constant envelope orthogonal frequency-division multiplexing (CE-OFDM). The portable communications device may include an antenna for receiving a CE-OFDM signal, and a receiver coupled to the antenna. The receiver may include a frequency domain equalizer (FDE) operating based upon a channel estimate of the received CE-OFDM signal, a non-linear function block coupled to and downstream from the FDE, and a demodulation correction block coupled to and downstream from the non-linear function block for correcting an output of the non-linear function block.

Method, apparatus, and system for securing freight

A harness assembly for restraining freight having a relatively high center of gravity comprises first and second junction rings, and four tensile members. Two of the four members form a bifurcated harness when connected to the junction rings. The third and fourth tensile members each have a ring end and an anchor end. The ring ends are connected to the junction rings. The bifurcated harness, having a top-contacting member and a side-contacting member, respectively contacts a top end and a side portion of positioned freight. The anchor ends anchor the third and fourth tensile members to a support structure such as a railcar floor. The third and fourth tensile members thereby diagonally direct tension into the bifurcated harness relative to the support structure so as to force the top end of the freight toward the support structure and the side portion of the freight toward the anchor ends.

Piperidine derivatives useful as ccr5 antagonists

The use of CCR5 antagonists of formula (I) or a pharmaceutically acceptable salt thereof, wherein X is -C(R13)2-, -C(R13)(R19)-, -C(O)-, -O-, -NH-, -N(alkyl)-, (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l), (m) or (n); R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R1 is H, alkyl or alkenyl; R2 is optionally substituted phenyl, phenylalkyl, heteroaryl or heteroarylalkyl, naphthyl, fluorenyl or diphenylmethyl; R3 is optionally substituted phenyl, heteroaryl or naphthyl; R4 is H, alkyl, fluoro-alkyl, cyclopropylmethyl, -CH¿2?CH2OH, -CH2CH2-O-alkyl, -CH2C(O)-O-alkyl, -CH2C(O)NH2, -CH2C(O)-NHalkyl or -CH2C(O)-N(alkyl)2; R?19¿ is optionally substituted phenyl, heteroaryl or naphthyl, cycloalkyl, cycloalkylalkyl or alkoxyalkyl; and R?5, R13, R14, R15 and R16¿ are hydrogen or alkyl for the treatment of HIV, solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis is disclosed, as well as novel compounds, pharmaceutical compositions comprising them, and the combination of CCR5 antagonists of the invention in combination with antiviral agents useful in the treatment of HIV or agents useful in the treatment of inflammatory diseases.

Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof

The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each of the substituents is as specified herein, formulations including the above compounds, processes for preparing the same and methods for treating vascular conditions, such as atherosclerosis or hypercholesterolemia, diabetes, obesity, stroke, demyelination and lowering plasma levels of sterols and/or stanols.

Tote Bag

A bag including a shell defining a sidewall, an upper portion, a rim, an opening, a front, a back, and a lower portion, wherein the opening is configured to allow access to a storage compartment, a semi-rigid base defining a bottom of the bag, wherein the shell and the semi-rigid base form the storage compartment, and a first internal divider panel attached to the sidewall and configured to transition from a first position to a second position, wherein the first position is a stowed configuration and the second position is in an extended configuration, a second internal divider panel attached to the sidewall opposite the first internal divider panel and configured to transition from the first position to the second position, wherein the first internal divider panel and the second internal divider panel are flush with the sidewall in the first position.

FIXING DEVICE FOR ROOF PANEL JOINTS

La présente invention concerne un dispositif de fixation pour joints de panneaux de toiture. Le dispositif de fixation présente des éléments de connexion externes espacés vers le haut à partir de la surface extérieure des panneaux et s'emboîtant avec les éléments de connexion internes sur la face intérieure des panneaux. Le dispositif de fixation présente un bord supérieur 36 emprisonné à l'intérieur de l'élément externe, une base 37 qui s'etend latéralement à partir de la bande supérieure 36 et se superpose à la surface à nu du noyau, un flasque 38 qui s'étend vers le bas à travers le noyau isolant vers la paroi interne 31. La fixation 40 qui passe à travers la base 37; le noyau isolant 15 et la paroi interne 31 fixe les panneaux de toiture adjacents sur l'élement structurel. Le dispositif de fixation est utilisé entre des premier et second panneaux de toiture. The present invention relates to a fixing device for joints of roofing panels. The fastener has outer connecting members spaced upwardly from the exterior surface of the panels and interlocking with the internal connecting members on the interior face of the panels. The fastener has an upper edge 36 trapped inside the outer member, a base 37 which extends laterally from the upper band 36 and is superimposed on the bare surface of the core, a flange 38 which extends downwardly through the insulating core towards the inner wall 31. The fastener 40 which passes through the base 37; the insulating core 15 and the inner wall 31 fixes the adjacent roof panels to the structural member. The fastener is used between first and second roof panels.

Tetrahydropyranochromene gamma secretase inhibitors

Disclosed are novel gamma secretase inhibitors of the formula. Also disclosed are methods of inhibiting gamma-secretase, methods of treating neurodegenerative diseases, and methods of treating Alzheimer's Disease. Also disclosed are processes for preparing alkenes in one reaction step using a mixture of an aldehyde (or ketone) and an alkyl substituted with two electron withdrawing groups, and reacting the mixture with: (a) a sulfonyl halide (e.g., a sulfonyl chloride) and a basic tertiary amine, or, (b) a sulfonyl anhydride and a basic amine, or (c) an aryl-C(O)-halide and a basic tertiary amine, or (d) an aryl-C(O)—O—C(O)-aryl and a basic tertiary amine, or (e) an heteroaryl-C(O)-halide and a basic tertiary amine, or (f) a heteroaryl-C(O)—O—C(O)-heteroaryl and a basic tertiary amine.

Method and apparatus for coordinating a change in service provider between a client and a server with identity based service access management

A method of configuring a network access device connected to an access network connected to a plurality of service networks, the network device having a first network address allocated to a subscriber of services of a first service provider provided by a first service network, with a new network address allocated to a second subscriber of services of either the first service provider, or a second service provider provided by a second service network. The method comprises the steps of: sending a request from the network access device to the access network with user credentials for the second subscriber requesting access to the first service provider or a change to the second service provider; receiving a response from the access network; and initiating a network address change request using a configuration protocol. In this manner, a second network address allocated to the second subscriber of services of either the first or second service providers is assigned to the network access device to enable the network access device to communicate data packets to the service network providing the selected service.

Decoupled fiber optic feedthrough assembly

A fiber optic device is provided with a feedthrough assembly adapted to decouple deflections imposed on the feedthrough from lensed end of a fiber disposed within the feedthrough assembly.

Liquor or wine bottle opener seal cutter

Treatment of drug-resistant human immunodeficiency virus infection

The invention provides methods for treating HIV infection in a subject in need thereof comprising lipid analogs of phosphonoformate-containing pharmaceutically active compounds. Lipid analogs contemplated for use in the practice of the present invention comprise phosphonoformates covalently linked (directly or indirectly through a linker molecule) to a substituted or unsubstituted alkylglycerol, alkylpropanediol, alkylethanediol, or related moiety. In particular, the invention provides methods for treating viral infections caused by viruses which have developed resistance to currently available antiviral agents, as well as methods comprising the use of invention compounds in combination with azidodeoxythymidine to minimize the selection of drug-resistant HIV variants during therapy.

Aryl oxime-piperazines useful as ccr5 antagonists

In one embodiment, this invention provides a novel class of aryl oxime-piperazine compounds as antagonists of the CCR5 receptor, methods of preparing such compounds, pharmaceutical compositions containing one or more of the compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention or amelioration of one or more of diseases associated with the CCR5 receptor. An illustrative inventive compound is shown below: (Formula I).

Power system for mobile workstation

A mobile powered workstation can include a head unit assembly that can have at least one power outlet configured to provide power to at least one electronic device. The workstation can include a power system coupled to the head unit assembly. The power system can include a permanent battery and a battery assembly. The battery assembly can include a battery connection housing that can have a plurality of power connectors configured to electrically couple to a corresponding plurality of power connectors of a replaceable battery, the battery connection housing can have a first face and a second face that extends from the first face. The first face can define a first raised portion configured to engage with a corresponding first recessed portion in the replaceable battery. The second face can define a second raised portion configured to engage with a corresponding second recessed portion in the replaceable battery.

Piperidine mch antagonists and their use in the treatment of obesity

Disclosed are compounds represented by structural formula (I) or a pharmaceutically acceptable salt, ester or solvate thereof, wherein W is R1~ - CR3~R12~NR4~C(O)- or R11~C(O)NR4~-; the dotted line is an optional double bond; X is CHR8~-, -C(O)-, or -C(=NOR9~)-; Y is (II); R1~ is optionally substituted cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkyl-alkyl; R2~ is optional ly substituted aryl or heteroaryl; R3~ is alkyl, aryl or heteroaryl; R4~ and R1 2~ are H or alkyl; R8~ is H, alkyl or alkoxyalkyl; R9~ is H, alkyl or arylalkyl ; R10~ is H, alkyl or aryl; R11~ is (III), or, when R2~ is R6~-heteroaryl or R10~ is not H, R11~ can also be R5~-phenylalkyl; n is 1-3 and m is 1-5; and R14~ is 1-3 substituents selected from H, alkyl, halogen, -OH, alkoxy and CF~3; and pharmaceutical compositions containing the compounds and methods o f using the compounds in the treatment of eating disorders and diabetes.</SDOA B>

Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof

The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each of the substituents is as specified herein, formulations including the above compounds, processes for preparing the same and methods for treating atherosclerosis, hypercholesterolemia, or sitosterolemia, and for lowering plasma levels of sterols and/or stanols.

Means for discharging smoke and gas from coke ovens

Adjustable flexibility sanding apparatus

A sanding apparatus includes a flexible base member which includes a base member bottom side and a base member top side. A quantity of abrasive material, e.g. a sheet of sandpaper, is adhesively attached to the base member bottom side. A flexible handle is positioned above the base member top side. Attachment means are provided for attaching the flexible base member to the flexible handle. Rod reception brackets are attached to the base member top side, and one or more flexibility adjustment rods are received in the rod reception brackets. The rod reception brackets include bracket rod reception channels which receive the flexibility adjustment rods. The flexible handle includes handle rod reception channels which are in registration with the bracket rod reception channels. Rod reception tubes are received in the bracket rod reception channels and the handle rod reception channels. The bracket rod reception channels are positioned adjacent to the base member top side such that the rod reception tubes are flush with the base member top side when the rod reception tubes are installed in the bracket rod reception channels. The flexibility adjustment rods are provided as a set of a plurality of flexibility adjustment rods which are increasing resistance to bending. The flexible handle includes a pair of finger grip grooves. The means for attaching the flexible base member to the flexible handle includes attachment wings on the rod reception brackets, and wing reception slots are provided in the flexible handle for receiving the attachment wings.

COMBINED, COMPOSED SUBSTANCE

Surgical assemblies and methods for visualizing and performing surgical procedures in reduced-access surgical sites

Assemblies and methods for carrying out a procedure on an organ or tissue in a closed or restricted space surgical site. A low profile head is configured and dimensioned to be delivered to a target location on the organ or tissue through an opening in a patient and having a contact surface configured to contact a surface of the organ or tissue at the target location. An elongated member extends proximally from the low profile head and has sufficient length so that a proximal end portion of the elongated member extends out of the opening in the patient when the contact surface of the head contacts the organ or tissue at the target location. The elongated member has a lumen extending longitudinally therethrough. An endoscope is dimensioned to be received in the lumen and has an elongated shaft of sufficient length such that when a distal tip of the endoscope extends into the head, and the contact surface contacts the organ or tissue at the target location, a proximal end portion of the elongated shaft of the endoscope extends out of the opening in the patient.

Power system for mobile workstation

A mobile powered workstation can include a head unit assembly that can have at least one power outlet configured to provide power to at least one electronic device. The workstation can include a power system coupled to the head unit assembly. The power system can include a permanent battery and a battery assembly. The battery assembly can include a battery connection housing that can have a plurality of power connectors configured to electrically couple to a corresponding plurality of power connectors of a replaceable battery, the battery connection housing can have a first face and a second face that extends from the first face. The first face can define a first raised portion configured to engage with a corresponding first recessed portion in the replaceable battery. The second face can define a second raised portion configured to engage with a corresponding second recessed portion in the replaceable battery.

Gamma secretase modulators

This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (Chemical formula should be inserted here as it appears on abstract in paper form). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's Disease using the compounds of formula (I).

Windshield cleaner

Ion-sensitive compounds

Ion-sensitive compounds are provided comprising a quaternary polypyridinium receptor designed to bind anionic species by the formation of a receptor-substrate complex. The receptor comprises one or more quaternary 2,2'-bipyridyl moieties and is represented by the formula R1-Y-R2 wherein Y is represented by structure (I) in which R1, R2, R3, R4 and q have meanings as given in the description. The compounds are of use in applications requiring anion detection or removal.

Piperazine derivatives useful as ccr5 antagonists

The use of CCR5 antagonists of formula (I) or a pharmaceutically acceptable salt thereof, wherein: R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R1 is hydrogen or alkyl; R2 is substituted phenyl, substituted heteroaryl, naphthyl, fluorenyl, diphenylmethyl or optionally substituted phenyl- or heteroaryl-alkyl; R3 is hydrogen, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, or optionally substituted phenyl, phenylalkyl, naphthyl, naphthylalkyl, heteroaryl or heteroarylalkyl; R4, R5 and R7 are hydrogen or alkyl; R6 is hydrogen, alkyl or alkenyl; for the treatment of HIV, solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis is disclosed, as well as novel compounds, pharmaceutical compositions comprising them, and the combination of CCR5 antagonists of the invention in combination with antiviral agents useful in the treatment of HIV or agents useful in the treatment of inflammatory diseases.

Display positioning apparatus and method

Embodiments of the invention include an apparatus for positioning an electronic display. The apparatus can be combined with an existing work surface to provide a multi-position workstation. In some cases the apparatus includes a mounting portion configured to support an electronic display and a keyboard. The mounting portion may be movable with respect to the work surface between multiple positions, including for example, a sitting position and a standing position. Methods for positioning an electronic display and a keyboard are also included.

Gasoline with copolymeric lead stabilizer and a synergistic modification thereof

Mono-esters of citric acid as metal deactivators for motor fuels

Bridged and fused heterocyclic antidiabetic compounds

This invention provides for certain bridged and fused heterocyclic compounds of the formula (I) or a pharmaceutically acceptable salt, ester solvate or prodrug thereof wherein: L is: (II) and the other variables are defined herein; the inventive compounds are agonists of the G-protein coupled receptor 40 (GPR40, also known as free fatty acid receptor FFAR). This invention further relates to pharmaceutical compositions containing these compounds, and the use of these compounds to regulate insulin levels in a mammal. The compounds may be used, for example in the prevention and treatment of Type 2 diabetes mellitus and in the prevention and treatment of conditions related to Type 2 diabetes mellitus, such as insulin resistance, obesity and lipid disorders.

Acylated ethers and process for making same

Piperazine derivatives useful as CCR5 antagonists

The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R 1 is hydrogen or alkyl; R 2 is substituted phenyl, substituted heteroaryl, naphthyl, fluorenyl, diphenylmethyl or optionally substituted phenyl- or heteroaryl-alkyl; R 3 is hydrogen, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, or optionally substituted phenyl, phenylalkyl, naphthyl, naphthylalkyl, heteroaryl or heteroarylalkyl; R 4 , R 5 and R 7 are hydrogen or alkyl; R 6 is hydrogen, alkyl or alkenyl; for the treatment of HIV, solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis is disclosed, as well as novel compounds, pharmaceutical compositions comprising them, and the combination of CCR5 antagonists of the invention in combination with antiviral agents useful in the treatment of HIV or agents useful in the treatment of inflammatory diseases.

Golf ball

Strap

System and method for communicating data using constant amplitude waveform with hybrid orthogonal and msk or gmsk modulation

A communications system of the present invention includes a transmitter that is operative for combining an orthogonal Walsh modulation with a minimum shift keying or Gaussian minimum shift keying waveform to form a hybrid communications signal that carries communications data over a constant amplitude waveform that is spread in time and frequency. This communications signal can be transmitted to a RAKE receiver that has a plurality of correlators with output weights formed for processing this hybrid communications signal.

Analgesic compositions

An analgesic composition in parenteral or sublingual unit dosage form comprising an active dose of buprenorphine and an amount of naltrexone sufficient to prove aversive to a narcotic addict by parenteral administration but insufficient to compromise the analgesic action of the buprenorphine.

Substituted Azetidinone Compounds, Processes for Preparing the Same, Formulations and Uses Thereof

The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each of the substituents is as specified herein, formulations including the above compounds, processes for preparing the same and methods for treating atherosclerosis, hypercholesterolemia, or sitosterolemia, and for lowering plasma levels of sterols and/or stanols.

Gripping strip for prefilled disposable syringes

Syringes for medical and diagnostic purposes have a gripping strip on the syringe barrel as an abutment for when the plunger is pushed into the syringe barrel during the administration process. The connection of the gripping strip to the syringe barrel has to withstand high pulling forces during this process, of up to 100 N. It is known to attach the gripping strip as a separate plastic part firmly to the syringe barrel, namely by means of a hollow-cylindrical seat (2) whose outside diameter is smaller than the inside diameter of the syringe barrel and in which there are moulded onto the outer surface catch elements (3) for a positive-locking operative connection to the syringe barrel, which has an internal undercut complementary to the catch elements (3), it being possible to introduce into the interior of the seat (2) a securing ring (4) for maintaining the operative connection. In order to reduce the manufacturing and mounting outlay, the securing ring (4) is integrally connected via predetermined breaking points (5) in a non-securing position to the interior of the seat (2) and is displaceable into the securing position as the syringe barrel is placed over the seat (2), the outer surface of the seat (2) being constructed only in peripheral portions and in gaps therebetween the catch elements (3) for the positive-locking operative connection to the internal undercut of the syringe barrel being moulded on.

Windshield wiper or the like

Method for dynamically displaying brand information in a user interface

Glass strengthening by ion exchange

Thermoelectric devices and applications for the same

High performance thin film thermoelectric couples and methods of making the same are disclosed. Such couples allow fabrication of at least microwatt to watt-level power supply devices operating at voltages greater than one volt even when activated by only small temperature differences.

Hinge construction

Osteoimplants and methods for their manufacture

An osteoimplant includes a coherent aggregate of elongate bone particles and has a bulk bone density of less than 3 g/cm3. The implant is contoured as a strip 10 having first and second ends, at least one of the ends having a tab 12 in the form of a step 11.

Piperidine derivatives useful as CCR5 antagonists

Coupler positioning device

FIXING DEVICE FOR WALL PANEL JOINTS

La présente invention concerne un dispositif de fixation pour joints de panneaux muraux du type à double paroi et à noyau en mousse 13. Un panneau présente une rainure 25 réalisée dans la paroi externe 11 qui s'étend latéralement vers l'intérieur d'un intervalle réalisé entre les bords adjacents des parois interne 12 et externe 11. Le panneau adjacent présente une languette 16 réalisée le long de la paroi externe 11 qui est engagée dans la rainure 25. Le dispositif de fixation comporte un élément de serrage 32 et une fixation 42. Le dispositif de fixation est utilisé pour fixer les panneaux muraux adjacents au niveau des joints sur un élement de charpente.

Composition and method for treating esophageal dysplasia

Enhancing the immune response to esophageal tumor cells reduces the incidence of esophageal cancer developing, recurring, or metastasizing. Esophageal cancer cells are modified to render them more immunogenic and proliferation compromised. They are used in an antigenic preparation to raise a T cell response in the recipient.

Piperidine and piperazine derivatives and their use as muscarinic antagonists

Di-N-substituted piperazine or 1,4 di-substituted piperidine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) wherein R, R1, R2, R3, R4, R21, R22, R28, X, Y and Z as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations of compounds of the above formula with acetylcholinesterase inhibitors.

Antioxidants

Pentafluorosulpholane-containing antidiabetic compounds

This invention provides for certain pentafluorosulpholane-containing compounds of the formula or a pharmaceutically acceptable salt, ester, solvate or prodrug thereof, wherein the variables are defined herein; the inventive compounds are agonists of the G-protein coupled receptor 40 (GPR40, also known as free fatty acid receptor FFAR). This invention further relates to pharmaceutical compositions containing these compounds, and the use of these compounds to regulate insulin levels in a mammal. The compounds may be used, for example in the prevention and treatment of Type 2 diabetes mellitus and in the prevention and treatment of conditions related to Type 2 diabetes mellitus, such as insulin resistance, obesity and lipid disorders.

Molecules that bind to prostate specific membrane antigen (psma) polypeptides

This document provides methods and materials involved in binding a binder (e.g., an antibody, antigen binding fragment, antibody domain, CAR, cell engager, and/or ADC) to a PSMA polypeptide. For example, binders (e.g., antibodies, antigen binding fragments, antibody domains, CARs, cell engagers, and/or ADCs) that bind to a PSMA polypeptide and methods and materials for using one or more such binding molecules to treat a mammal (e.g., a human) having cancer are provided.

Production of refractory silica articles

Turbine wheel burst containment means

MCH antagonists and their use in the treatment of obesity

The present invention discloses compounds of the formula (I) which are novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.

Protein V:AIgG binding factor

A novel bacterial proteinaceous immunoglobulin G receptor is disclosed. The proteinaceous factor binds all four subclasses of human IgG, as well as rabbit, swine, equine, bovine, sheep, and goat IgG. The proteinaceous factor is obtained from biologically pure cultures of Gardnerella vaginalis such as those having the identifying characteristics of ATCC Deposit No. 55195.

Engine-gearing.

polynucleotides for cry1f 281-24-236 and cry1ac 3006-210-23 events

linhagens transgênicas de algodão, cry1f e cry1ac, e sua identificação específica de evento. a presente invenção refere-se ao cruzamento de plantas e à proteção de plantas contra insetos. mais especificamnte, esta invenção inclui eventos de transformação inusitados de plantas de algodão, que compreendem uma ou mais seqüências de polinucleotédeos, como aqui descritas, inseridas dentro de um sítio ou sítios específicos dentro do genoma de uma célula de algodão. em modalidades altamente preferidas, as ditas seqüências de polinucleotídeos codificam as proteínas inibitórias de insetos lepidópteros, cry1f e cry1ac "combinadas". entretanto, a invenção em questão inclui plantas que têm um único evento cry1f ou cry1ac, como aqui descrito. adicionalmente, a invenção refere-se a plantas de algodão derivadas desse evento de transformação e ensaios para detectar a presença do evento em uma amostra. mais especificamente, a presente invenção fornece ensaios de dna e ensaios relacionados para detectar a presença de certos eventos de resistência a insetos em algodão. os ensaios baseiam-se nas seqüências de dna de constructos recombinantes inseridos dentro do genoma do algadão e das seqüências genômicas que flanqueiam os sítios de inserção. estas seqüências são singulares. baseado nessas seqüências de inserções e limítrofes, foram gerados inciadores específicos de eventos. a análise por pcr demonstrou que essas linhagens de algodão podem ser identificadas em diferentes genótipos de algodão por análise dos amplicons da pcr gerados com esses conjuntos de iniciadores específicos de eventos. assim sendo, estes procedimentos e outros procedimentos afins podem ser usados para identificar singularmente essas linhagens de algodão. são fornecidos também kits e condições úteis para conduzir os ensaios. estes materiais e métodos podem ser usados também para auxiliar programas de enxertia, a fim de desenvolver traços no algodoeiro. transgenic cotton strains, cry1f and cry1ac, and their ...

Wound healing method and kits

Electroporation is used to enhance the wound-healing benefit provided by transfection of nucleic acids that encode cellular growth factors. Wounds which are amenable to the method include inter alia cutaneous lesions, muscular lesions, osseus lesions, burn wounds, and gastrointestinal anastamoses. Kits comprise electrodes and nucleic acids encoding cellular growth factors.

Car-brake.

Light entangled nonwoven nonwoven with good tear strength in the machine and cross directions and method of making the same.

Drying tumbler

Wireless communication system with selective preamble synchronization portion and related methods

A wireless communications device may include a transceiver, a memory configured to store a predetermined set of preamble synchronization portions, each preamble synchronization portion having a different length, and a controller cooperating with the transceiver and the memory. The controller may be configured to receive forward transmission blocks, each forward transmission block having a preamble synchronization portion and a body portion associated therewith. The preamble synchronization portion may include a desired preamble synchronization portion from among the predetermined set of preamble synchronization portions. The controller may be configured to determine and use, for each received forward transmission block, the corresponding preamble synchronization portion from among the predetermined set of preamble synchronization portions.

Gamma secretase modulators

In its many embodiments, the present invention provides a novel class of heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.

Process for the production of high octane gasolines

Novel gamma secretase inhibitors

Gamma-secretase inhibitors of the formula: Chemical formula should be inserted here as it appears on the abstract in paper form. are useful in treating various neurodegenerative diseases, wherein, for example: R1 includes unsubstituted or substituted aryl or heteroaryl groups; R2 includes -C(O)-Y, alkylene-C(O)-Y, alkylene-cycloalkylene-C(O)-Y, cycloalkylene-alkylene-C(O)-Y, alkylene cycloalkylene-alkylene-C(O)-Y, cycloalkylene-C(O)-Y, -S(O)-Y, alkylene-S(O)-Y, alkylene-cycloalkylene-S(O)-Y, cycloalkylene-alkylene-S(O)-Y, alkylene cycloalkylene-alkylene-S(O)-Y, cycloalkylene-S(O)-Y, -S(O2)-Y, alkylene-S(O2)-Y, alkylene cycloalkylene S(O2)-Y, cycloalkylene alkylene S(O2)-Y, alkylene cycloalkylene-alkylene-S(O2)-Y, and cycloalkylene-S(O2)-Y, wherein Y is as defined herein, and each of said alkylene or cycloalkylene may be unsubstituted or substituted as provided herein; each R3 is independently includes H, alkyl, O alkyl, OH, N(R9)2, acyl, and aroyl; or the moiety (R3)2, together with the ring carbon atom to which it is shown attached in formula I, defines a carbonyl group, -C(O)-; each R3A and R3B independently includes H, or alkyl; R11 includes aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, arylheterocycloalkyl, or alkoxyalkyl. One or more of the compounds of formula I, or pharmaceutically acceptable salts, solvates, and/or esters, or compositions comprised thereof, may be used to treat, e.g., Alzheimer's Disease.

Communications system using adaptive filter that is selected based on output power

A communications system receives a modulated signal that carries encoded communications data. An adaptive filter has an input, a plurality of non-adaptive and adaptive filter taps with weighted coefficients, and an output. The received signal is passed through the adaptive filter and around adaptive filter and a switch selects which signal to pass to demodulator based on measured output power of the adaptive filter and of the original received signal. A demodulator and decoder receive the filtered output signal and demodulate and decode the signal to obtain the communications data.