Verfahren zum Herstellen von Ruß unter Verwendung eines vorgewärmten Ausgangsmaterials und Apparatur zum Durchführen des Verfahrens

Verfahren zum Herstellen von Ruß, umfassend:das Einbringen eines heißen Gasstroms in einen Rußreaktor;das Einbringen mindestens eines rußbildenden Ausgangsmaterials mit einer ersten Temperatur in mindestens einen Heizer;das Vorwärmen des mindestens einen rußbildenden Ausgangsmaterials in dem mindestens einen Heizer auf eine zweite Temperatur von mehr als etwa 300°C, wobei ein vorgewärmtes rußbildendes Ausgangsmaterial erhalten wird, wobei (a) das mindestens eine rußbildende Ausgangsmaterial in dem mindestens einen Heizer eine Geschwindigkeit hat, die mindestens 0,2 m/s beträgt, wobei die Geschwindigkeit auf der Basis einer Ausgangsmaterialdichte, gemessen bei 60°C bei 1 atm, und auf der Basis der kleinsten Querschnittsfläche der Leitung zum Transportieren des Ausgangsmaterials in dem mindestens einem Heizer berechnet wird, und wobei (b) eine erste Verweildauer des mindestens einen rußbildenden Ausgangsmaterials in dem Heizer weniger als etwa 120 Minuten beträgt;das Einbringen des vorgewärmten ...

Verfahren zum Herstellen von Ruß unter Verwendung eines vorgewärmten Ausgangsmaterials und Apparatur zum Durchführen des Verfahrens

Die Erfindung betrifft Verfahren zum Herstellen von Ruß unter Verwendung eines Ausgangsmaterials mit einer Temperatur von mehr als etwa 300°C, die mindestens eine Antifoulingmaßnahme umfassen. Die Erfindung betrifft weiterhin eine Apparatur zum Herstellen von Ruß, die in den erfindungsgemäßen Verfahren verwendet werden kann.

Aqueous fatty quaternary amine-containing carrier systems for water-insoluble materials

The present invention is drawn to a carrier composition containing: (a) at least one fatty quaternary amine compound; (b) at least one nonionic surfactant; (c) at least one anionic silicone; and (d) at least one water-insoluble material, and wherein the composition, when combined with an aqueous phase, forms an aqueous delivery system which is both stable, and clear to slightly hazy/limpid in appearance.

Blended polymer fets

A method for forming a semiconductor body, the method comprising: forming a mixture of an organic semiconducting material and a binder material; causing the semiconducting material to at least partially solidify; and causing the binder material to crystallize in such a way as to cause the semiconducting material to at least partially segregate from the binder material.

Detecting a defect within a bodily sample

Apparatus and methods are described for analyzing a bodily sample. One or more microscope images of the bodily sample are acquired. Using at least one computer processor at least one sample-informative feature that is indicative of a characteristic of the bodily sample is extracted from the images. Based upon the sample-informative feature, the computer processor determines that there is a defect associated with the bodily sample, and determines a source of the defect. Other applications are also described.

METHODS FOR ELEVATION OF LIPID AND CHOLESTEROL METABOLISM

The present invention relates to methods of using compositions comprising intact mitochondria and/or ruptured mitochondria for elevating lipid metabolism in cells. The present invention further provides methods for treating diseases which benefit from elevation of lipid and cholesterol metabolism and methods for inducing weight loss or reducing weight gain comprising administering compositions comprising intact mitochondria and/or ruptured mitochondria to a subject in need thereof. 152-. (canceled)53. A composition comprising intact mitochondria and/or ruptured mitochondria wherein the composition elevates lipid and cholesterol metabolism or induces weight loss or attenuates or reduces weight gain in a subject in need thereof.54. The composition according to claim 53 , wherein the composition comprising the ruptured mitochondria further comprises at least one mitochondrial constituent released from the ruptured mitochondria selected from the group consisting of: mitochondrial protein claim 53 , mitochondrial nucleic acid claim 53 , mitochondrial lipid claim 53 , mitochondrial peptide claim 53 , mitochondrial saccharide claim 53 , mitochondrial structure claim 53 , at least part of a mitochondrial matrix and a combination thereof.55. The composition according to claim 53 , wherein the composition comprising the intact mitochondria further comprises a hypertonic solution.56. The composition according to claim 53 , wherein the mitochondria are:a) isolated mitochondria, wherein the weight of the mitochondrial proteins in the isolated mitochondria constitutes more than 80% of the combined weight of the mitochondria and other sub-cellular cellular proteins;b) partially purified mitochondria, wherein the weight of the mitochondrial proteins in the partially purified mitochondria constitutes between 10%-80% of the combined weight of the mitochondria and other sub-cellular proteins; orc) partially purified mitochondria, wherein the weight of the mitochondrial proteins in the ...

METHODS AND APPARATUS FOR DETECTING AN ENTITY IN A BODILY SAMPLE

Apparatus and methods for analyzing a bodily sample are described. A microscope system acquires one or more microscope images of the bodily sample. A computer processor identifies, in the one or more images, at least one element as being a candidate of a given entity. The computer processor extracts, from the one or more images, at least one candidate-informative feature associated with the candidate of the given entity, and at least one sample-informative feature that is indicative of a characteristic of the bodily sample as a whole. The computer processor processes the candidate-informative feature in combination with the sample-informative feature, and generates an output upon the output device, in response thereto. Other applications are also described. 1. Apparatus for analyzing a bodily sample , the apparatus comprising:a microscope system configured to acquire one or more microscope images of the bodily sample;an output device; and identify, in the one or more images, at least one element as being a candidate of a given entity,', 'extract, from the one or more images, at least one candidate-informative feature associated with the candidate of the given entity,', 'extract, from the one or more images, at least one sample-informative feature that is indicative of a characteristic of the bodily sample as a whole,', 'process the candidate-informative feature in combination with the sample-infonnative feature, and', 'generate an output upon the output device, in response thereto., 'at least one computer processor configured to2. The apparatus according to claim I , wherein the at least one computer processor is configured to extract , from the one or more images , at least one candidate-informative feature associated with the candidate by extracting , from the one or more images , at least one candidate-informative feature associated with the candidate , the candidate-informative feature being a feature selected from the group consisting of: a size of the ...

Methods and devices for neuromodulation of the adrenal gland

Aspects of the present disclosure are directed toward apparatuses, systems, and methods for delivering therapy to an adrenal gland of a patient. The apparatuses, systems, and methods may include a housing and a plurality of electrodes arranged with the housing. In addition, one or more of the plurality of electrodes may deliver stimulation energy to modulate L-dopa release.

Time-based cluster imaging

In an example method, a series of time-based clustering images is generated for a plurality of library fragments from a genome sample. Each time-based clustering image in the series is sequentially generated. To generate each time-based clustering image in the series: i) a respective sample is introduced to a flow cell, the respective sample including contiguity preserved library fragments of the plurality of library fragments, wherein the contiguity preserved library fragments are attached to a solid support or are attached to each other; ii) the contiguity preserved library fragments are released from the solid support or from each other; iii) the contiguity preserved library fragments are amplified to generate a plurality of respective template strands; iv) the respective template strands are stained; and v) the respective template strands are imaged.

Disc Brake for a Commercial Vehicle and Brake Pad Set

A disc brake includes a brake caliper that engages over a brake disc, the caliper having a central opening over the brake disc. The disc brake has two brake pads which are located in the brake caliper, can be moved in opposite directions and each of which has a pad backing plate with a friction lining secured thereon. An action-side or application-side brake pad of the two brake pads can be pressed against the brake disc by a brake application device with the aid of at least one brake plunger. The brake also has at least one restoring device, by which the brake caliper can be returned. The restoring device has a spreading device which engages on the brake pads lying opposite one another and which acts with an identical force in opposition to the respective application direction. The spreading device has spring-loaded spreading elements, each engaging on its respective pad backing plate. The spreading device is located in the central opening and the spreading elements engage directly or indirectly, outside the friction linings, on at least two contact regions of the brake pads. These regions face each other at a distance from the center. The spreading device has spring-loaded arms which are interconnected in the central region of the opening and connected to a retaining bracket which is attached to the brake support plate.

Compositions of functional mitochondria and uses thereof

Mitochondrial compositions and therapeutic methods of using same. Compositions of partially purified functional mitochondria and methods of using the compositions to treat conditions which benefit from increased mitochondrial function by administering the compositions to a subject in need thereof.

Contiguity Preserving Transposition

Embodiments provided herein relate to methods and compositions for preparing an immobilized library of barcoded DNA fragments of a target nucleic acid, identifying genomic variants, determining the contiguity information, phasing information, and methylation status of the target nucleic acid.

Antibodies against clostridium difficile toxins and methods of using the same

Monoclonal antibodies, or antigen-binding fragments thereof, that bind to Clostridium difficile ( C. difficile ) toxin A or toxin B and methods of using the same to detect or treat C. difficile infections and/or C. difficile -associated disease.

MITOCHONDRIAL AUGMENTATION THERAPY OF RENAL DISEASES

The present invention provides stem cells enriched with healthy functional mitochondria, pharmaceutical compositions comprising these cells and methods of use thereof for treating renal diseases, disorders and symptoms thereof where the disease may or may not be associated with acquired mitochondrial dysfunction. 1. A method of treating a renal disease , disorder or a symptom thereof in a human patient in need of such treatment comprising administering parenterally a pharmaceutical composition to the patient , the pharmaceutical composition comprising at least about 5×10to 5×10human stem cells , wherein the human stem cells are enriched with human exogenous mitochondria , and wherein the renal disease or disorder is not a primary mitochondrial disease or disorder caused by a pathogenic mutation in mitochondrial DNA or by a pathogenic mutation in nuclear DNA encoding a mitochondrial protein.2. The method of claim 1 , wherein the exogenous mitochondria are syngeneic or allogeneic.3. The method of claim 1 , wherein the disease or disorder is selected from the group consisting of nephropathy claim 1 , nephritis claim 1 , nephrosis claim 1 , nephritic syndrome claim 1 , nephrotic syndrome claim 1 , Fanconi's syndrome and kidney failure.4. The method of claim 1 , wherein the symptom is selected from the group consisting of low blood alkaline phosphatase levels claim 1 , low blood magnesium levels claim 1 , high blood creatinine levels claim 1 , low blood bicarbonate levels claim 1 , low blood base excess levels claim 1 , high urine glucose/creatinine ratios claim 1 , high urine chloride/creatinine ratios claim 1 , high urine sodium/creatinine ratios claim 1 , high blood lactate levels claim 1 , high urine magnesium/creatinine ratios claim 1 , high urine potassium/creatinine ratios claim 1 , high urine calcium/creatinine ratios and high blood urea levels.5. The method of claim 1 , wherein the mitochondrially-enriched human stem cells have at least one of:(i) an increased ...

Steering of Target Poles in an Electrode Array in a Pulse Generator System

Techniques for steering of target poles formed by implantable electrodes in a stimulator device are disclosed. The steering technique modifies the relative amplitude of target poles once they are steered to an electrode array boundary. Once a target pole is steered to an electrode array boundary, further steering in the direction of that boundary results in a gradual decrease in the relative amplitude of that target pole. Eventually, continued steering in that direction will cause that target pole to disappear. Thus, in the case of a target tripole, continued steering will eventually cause the target tripole to be automatically converted into a target bipole. In another example of steering, target poles defined linearly in one direction can be split in an orthogonal direction to create a target pole configuration that is two-dimensional.

Mitochondrial augmentation therapy of pancreatic diseases

The present invention provides stem cells enriched with healthy functional mitochondria, pharmaceutical compositions comprising these cells and methods of use thereof for treating pancreatic diseases, disorders and symptoms thereof where the disease may or may not be associated with acquired mitochondrial dysfunction.

MITOCHONDRIAL AUGMENTATION THERAPY OF LIVER DISEASES

The present invention provides stem cells enriched with healthy functional mitochondria, pharmaceutical compositions comprising these cells and methods of use thereof for treating liver diseases, disorders and symptoms thereof where the disease may or may not be associated with acquired mitochondrial dysfunction. 13.-. (canceled)4. The method of claim 28 , wherein the human exogenous mitochondria are syngeneic or allogeneic.56.-. (canceled)7. The method of claim 28 , wherein the disease or disorder is selected from the group consisting of a drug-induced hepatopathy claim 28 , Non-alcoholic fatty liver disease (NAFLD) claim 28 , Nonalcoholic Steatohepatitis (NASH) claim 28 , alcohol-related liver disease claim 28 , cirrhosis claim 28 , autoimmune hepatitis and Wilson's disease.8. The method of claim 28 , wherein the symptom is selected from the group consisting of low blood alkaline phosphatase levels claim 28 , high aspartate aminotransferase (AST) levels claim 28 , high alanine aminotransferase (ALT) levels claim 28 , high lactic dehydrogenase (LDH) claim 28 , high triglyceride levels claim 28 , high total cholesterol levels and high VLDL cholesterol levels.912.-. (canceled)1416.-. (canceled)17. The method of claim 28 , wherein the human stem cells are hematopoietic stem cells claim 28 , mesenchymal stem cells claim 28 , pluripotent stem cells (PSCs) claim 28 , induced pluripotent stem cells (iPSCs) claim 28 , or CD34+ cells.1821.-. (canceled)22. The method of claim 28 , wherein the human stem cells are isolated claim 28 , derived or obtained from cells of the bone marrow claim 28 , adipose tissue claim 28 , oral mucosa claim 28 , skin fibroblasts claim 28 , blood or umbilical cord blood.23. The method of claim 28 , wherein the human exogenous mitochondria are isolated or obtained from placenta claim 28 , placental cells grown in culture or blood cells.24. (canceled)25. The method of claim 28 , wherein the human exogenous mitochondria constitute at least 1%-30% of ...

Biosensor Device and Methods

The invention provides a sensor device comprising an insect odorant receptor complex, comprising an OrX and an Oreo, in electrical communication with a substrate, wherein the sensor device is configured to detect a change in an electrical characteristic of the substrate. The invention also provides sensor device component comprising an insect odorant receptor complex, comprising an OrX and an Oreo, in electrical communication with a substrate. The invention also provides methods for manufacture and use of the sensor device and sensor device component. The invention also provides methods of use of the sensor to detect an analyte.

MITOCHONDRIAL AUGMENTATION THERAPY FOR PRIMARY MITOCHONDRIAL DISEASES

The present invention provides human stem cells enriched with functional mitochondria, wherein the healthy functional exogenous mitochondria constitute at least 3% and less than 33% of the total mitochondria in the mitochondrially-enriched human stem cells. Further disclosed are methods for the production of such cells, and uses thereof for the treatment of primary mitochondrial diseases. 13.-. (canceled)4. The method of claim 37 , wherein the human exogenous mitochondria are syngeneic or allogeneic.56.-. (canceled)7. The method of claim 37 , wherein the mitochondrial disease or disorder is associated with a mutation in mitochondrial DNA selected from the group consisting of Pearson syndrome; Kearns-Sayre syndrome; a Mitochondrial encephalopathy lactic acidosis and stroke-like episodes (MELAS) syndrome; Leber's hereditary optic neuropathy (LHON); Neuropathy claim 37 , ataxia claim 37 , and retinitis pigmentosa (NARP) syndrome; myoclonic epilepsy with ragged red fibers (MERRF) syndrome; maternally inherited diabetes and deafness (MIDD); Alpers-like syndrome; Chronic progressive external ophthalmoplegia (CPEO); mitochondrial DNA-associated forms of Congenital lactic acidosis (CLA); Mitochondrial DNA depletion Syndrome (MDDS); mitochondrial DNA-associated forms of Leigh syndrome claim 37 , Mitochondrial neurogastrointestinal encephalopathy (MNGIE) syndrome; Alpers syndrome; Friedreich's ataxia (FA); progressive external ophthalmoplegia (PEO); Sideroblastic anemia; an ataxia neuropathy syndrome (ANS); a Mendelian neurodegenerative mitochondriopathy; 3-methylglutaconic aciduria (MEG) deafness (D) claim 37 , encephalopathy (E) and Leigh-like disease (L) syndrome (MEGDEL); Sengers syndrome; Minimal change nephrotic syndrome (MCNS); nuclear DNA-associated forms of Congenital lactic acidosis (CLA); and nuclear DNA-associated forms of Leigh syndrome.89.-. (canceled)10. The method of claim 37 , wherein the mitochondrial disease or disorder is associated with an organ selected ...

MITOCHONDRIAL AUGMENTATION THERAPY OF RENAL DISEASES

The present invention provides stem cells enriched with healthy functional mitochondria, pharmaceutical compositions comprising these cells and methods of use thereof for treating renal diseases, disorders and symptoms thereof where the disease may or may not be associated with acquired mitochondrial dysfunction. 13.-. (canceled)4. The method of claim 28 , wherein the exogenous mitochondria are syngeneic or allogeneic.56.-. (canceled)7. The method of claim 28 , wherein the disease or disorder is selected from the group consisting of nephropathy claim 28 , nephritis claim 28 , nephrosis claim 28 , nephritic syndrome claim 28 , nephrotic syndrome claim 28 , Fanconi's syndrome and kidney failure.8. The method of claim 28 , wherein the symptom is selected from the group consisting of low blood alkaline phosphatase levels claim 28 , low blood magnesium levels claim 28 , high blood creatinine levels claim 28 , low blood bicarbonate levels claim 28 , low blood base excess levels claim 28 , high urine glucose/creatinine ratios claim 28 , high urine chloride/creatinine ratios claim 28 , high urine sodium/creatinine ratios claim 28 , high blood lactate levels claim 28 , high urine magnesium/creatinine ratios claim 28 , high urine potassium/creatinine ratios claim 28 , high urine calcium/creatinine ratios and high blood urea levels.912.-. (canceled)13. The method of claim 28 , wherein the mitochondrially-enriched human stem cells have at least one of:an increased mitochondrial DNA content;(ii) an increased level of citrate synthase (CS) activity;(iii) an increased content of at least one mitochondrial protein selected from SDHA and COX1;(iv) an increased rate of 02 consumption;(v) an increased rate of ATP production; or(vi) any combination thereof, relative to the corresponding level in the stem cells prior to mitochondrial enrichment.1416.-. (canceled)17. The method of claim 28 , wherein the human stem cells are hematopoietic stem cells claim 28 , mesenchymal stem cells claim ...

MITOCHONDRIAL AUGMENTATION THERAPY OF OCULAR DISEASES

The present invention provides stem cells enriched with healthy functional mitochondria, pharmaceutical compositions comprising these cells and methods of use thereof for treating ocular diseases, disorders and symptoms thereof where the disease may or may not be associated with acquired mitochondrial dysfunction. 13.-. (canceled)4. The method of claim 32 , wherein the human exogenous mitochondria are syngeneic or allogeneic.56.-. (canceled)7. The method of claim 32 , wherein the disease or disorder is selected from the group consisting of Chronic Progressive External Ophthalmoplegia (CPEO) claim 32 , dominant optic atrophy (DOA) claim 32 , Kjer optic neuropathy claim 32 , Retinitis Pigmentosa claim 32 , age-related macular degeneration (AMD) claim 32 , diabetic retinopathy claim 32 , cataracts claim 32 , glaucoma and Pigmentary Retinopathy.8. (canceled)9. The method of claim 32 , wherein the symptom is selected from the group consisting of ptosis claim 32 , tunnel vision claim 32 , reduced eye motility claim 32 , severe external ophthalmoplegia claim 32 , strabismus claim 32 , nystagmus claim 32 , low visual acuity claim 32 , refractive error claim 32 , photophobia claim 32 , partial or total optic atrophy claim 32 , night blindness claim 32 , cataracts claim 32 , blindness claim 32 , central vision loss claim 32 , light sensitivity claim 32 , death of retinal ganglion cells or retinal epithelial cells claim 32 , optic atrophy claim 32 , optic neuropathy claim 32 , retinopathy and blurring and clouding of vision.10. (canceled)11. The method of claim 32 , wherein said pharmaceutical composition is administered directly to the eye claim 32 , to the ocular system or by systemic administration.1215.-. (canceled)1719.-. (canceled)20. The method of claim 32 , wherein the human stem cells are hematopoietic stem cells claim 32 , mesenchymal stem cells claim 32 , pluripotent stem cells (PSCs) claim 32 , induced pluripotent stem cells (iPSCs) claim 32 , or CD34+ cells.2124 ...

Mitochondrial augmentation therapy of brain diseases

The present invention provides stem cells enriched with healthy functional mitochondria, pharmaceutical compositions comprising these cells and methods of use thereof for treating brain diseases, disorders and symptoms thereof where the disease may or may not be associated with acquired mitochondrial dysfunction.

Methods and apparatus for detecting an entity in a bodily sample

Apparatus and methods are described including a microscope system (11) configured to acquire one or more micro scope images of a bodily sample, an output device (34), and at least one computer processor (28). The computer processor identifies, in the one or more images, at least one element as being a pathogen candidate, and extracts, from the one or more images, at least one candidate-informative feature associated with the pathogen candidate. The compute processor extracts, from the one or more images, at least one sample-informative feature that is indicative of contextual information related to the bodily sample. The computer processor classifies a likelihood of the bodily sample being infected with a pathogenic infection, by processing the candidate-informative feature in combination with the sample-informative feature, and generates an output upon the output device, in response thereto. Other applications are also described.

DETERMINING A DEGREE OF RED BLOOD CELL DEFORMITY WITHIN A BLOOD SAMPLE

Apparatus and methods are described including acquiring microscopic images of a blood sample, and identifying deformed red blood cells within the microscopic images. A degree of red blood cell deformity within the sample is determined, at least partially based upon the identified deformed red blood cells. A sample-informative parameter that is indicative of a characteristic of the blood sample as a whole is determined, at least partially based upon the degree of red blood cell deformity within the sample. Other applications are also described. 1. A method comprising:acquiring microscopic images of a blood sample;identifying deformed red blood cells within the microscopic images;determining a degree of red blood cell deformity within the sample, at least partially based upon the identified deformed red blood cells; anddetermining a sample-informative parameter that is indicative of a characteristic of the blood sample as a whole, at least partially based upon the degree of red blood cell deformity within the sample.2. The method according to claim 1 , wherein identifying deformed red blood cells within the microscopic images comprises identifying echinocytes within the microscopic images.3. The method according to claim 1 , wherein identifying deformed red blood cells within the microscopic images comprises identifying acanthocytes within the microscopic images.4. The method according to claim 1 , wherein determining the sample-informative parameter at least partially based upon the degree of red blood cell deformity within the sample comprises determining that the sample has a pathology claim 1 , at least partially based upon the degree of red blood cell deformity within the sample.5. The method according to claim 1 , wherein determining the sample-informative parameter at least partially based upon the degree of red blood cell deformity within the sample comprises determining that the sample is infected with a pathogen claim 1 , at least partially based upon the ...

DETERMINING A STAINING-QUALITY PARAMETER OF A BLOOD SAMPLE

Apparatus and methods are described including staining a blood sample with one or more stains. A plurality of microscopic images of the stained blood sample are acquired, using a microscope. Staining-quality parameters for respective microscopic images are determined, using a computer processor, the staining-quality parameters being indicative of a quality of the staining within each of the respective microscopic images. An action is performed by the computer processor, based upon the staining-quality parameters of the respective microscopic images. Other applications are also described. 1. A method comprising:staining a blood sample with one or more stains;acquiring a plurality of microscopic images of the stained blood sample, using a microscope;using at least one computer processor, determining staining-quality parameters for respective microscopic images, the staining-quality parameters being indicative of a quality of the staining within each of the respective microscopic images; andusing the at least one computer processor, performing an action based upon the staining-quality parameters of the respective microscopic images.2. The method according to claim 1 , wherein performing the action based upon the staining-quality parameters of the respective microscopic images comprises discarding at least some of the microscopic images from being used in an analysis of the blood sample in response to determining that the staining quality of the at least some of the microscopic images is not sufficient.3. The method according to claim 1 , wherein performing the action based upon the staining-quality parameters of the respective microscopic images comprises adjusting one or more thresholds that are used for identifying entities within respective microscopic images claim 1 , based upon the staining-quality parameters of the respective microscopic images.4. The method according to claim 1 , wherein performing the action based upon the staining-quality parameters of the ...

Amantadine compositions, preparations thereof, and methods of use

Provided herein are oral pharmaceutical compositions comprising amantadine, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient, and which have a low level of organic solvent. Provided are also methods of orally administrating a composition comprising amantadine, or a pharmaceutically acceptable salt thereof, to a subject, which has reduced gastrointestinal side effects or sleep disturbances. Further provided are extended release oral compositions comprising amantadine, or a pharmaceutically acceptable salt thereof, that are suitable for once daily administration.

Impact modifier based on polyisobutane for polyamides

A thermoplastic molding composition containing A) 20 to 99.9 wt % of a thermoplastic polyamide, B) 0.1 to 40 wt % of an alkenylsuccinic acid derivative obtained by reaction of polyiso-butene (B1) having a number-average molecular weight Mn of 10,000 to 50,000 at temperatures of 180° C. to 250° C. with maleic acid or derivatives thereof (B2) in a stoichiometric ratio of at least 2 equivalents of α,β-unsaturated mono- and dicarboxylic acid or derivatives thereof (B2) per reactive double bond in the polyisobutene (B1) for a duration of at least 15 minutes to 10 hours and up to 10 bar of positive pressure, wherein the derivatives are anhydrides, mono- or dialkyl esters, and mixed esters, and wherein the reactive double bonds are the sum total of the terminal α- and β-double bonds in the polyisobutene (B1), and C) 0 to 60 wt % of further additives, wherein the weight percentages for the components A) to C) sum to 100%.

Mammalian cells enriched with functional mitochondria

The present invention provides human bone-marrow cells enriched with functional mitochondria, methods for their production, and therapeutic methods utilizing such cells.

Wipe dispenser

A dispenser for the wipes is described suitable for use in a shower environment, utilizing a shell having opposed top and bottom ends and, in a preferred embodiment, a support device connected to the shell for securing the dispenser to an outside surface. In another embodiment, the dispenser prevents water spray from the shower from contaminating the wipes contained therein. The bottom end has a dispensing slot with a length dimension greater than a width dimension and a finger-access opening to enable the user to urge wipes in the direction of the dispensing slot. The inventive wipe dispenser also is conveniently refilled with disposable wipes.

Blended polymer fets

A method for forming a semiconductor body, the method comprising: forming a mixture of an organic semiconducting material and a binder material; causing the semi conducting material to at least partially solidify; and causing the binder material to crystallize in such a way as to cause the semi conducting material to at least partially segregate from the binder material.

Prosthetic component for monitoring synovial fluid and method

A prosthetic component suitable for long-term implantation is provided. The prosthetic component includes electronic circuitry and sensors to measure a parameter of the muscular-skeletal system. The prosthetic component comprises a first structure having at least one support surface, a second structure having at least one feature configured to couple to bone, and at least one sensor. The electronic circuitry and sensors are hermetically sealed within the prosthetic component. One or more sensors can be used to monitor synovial fluid in proximity to the joint to determine joint health. The prosthetic component includes a transmissive region. One or more optical sensors are mounted in proximity to the transmissive region. Periodic measurements of the synovial fluid are measured through the transmissive region. The measurements can include color and turbidity of the synovial fluid. The color and turbidity data can be compared against known data to determine joint status.

Sensored prosthetic component and method

A prosthetic component suitable for long-term implantation is provided. The prosthetic component includes electronic circuitry and sensors to measure a parameter of the muscular-skeletal system. The prosthetic component comprises a first structure having at least one support surface, a second structure having at least one feature configured to couple to bone. The electronic circuitry and sensors are hermetically sealed within the prosthetic component. Sensors can be used to monitor synovial fluid in proximity to the joint to determine joint health. The prosthetic component can include a temperature sensor or a pH sensor. The temperature or pH of the synovial fluid can be correlated to a variety of joint conditions. Measurements over time can be analyzed for trends. The temperature or pH can be calibrated for the patient. For example, calibration can be for temperature or pH of a patient healthy joint. The measurements are compared against this patient reference.

Prosthetic component for monitoring joint health

A prosthetic component suitable for long-term implantation is provided. The prosthetic component includes electronic circuitry and sensors to measure a parameter of the muscular-skeletal system. The prosthetic component comprises a first structure having at least one support surface, a second structure having at least one feature configured to couple to bone, and at least one sensor. The electronic circuitry and sensors are hermetically sealed within the prosthetic component. The prosthetic component includes at least on transmissive region. The transmissive region can be located in a region that has exposure to a region outside the joint. The transmissive region can comprise glass. One or more sensors can be used to monitor synovial fluid in proximity to the joint to determine joint health. The transmissive region can be used to support communication between the electronic circuitry and remote system.

Sensored prosthetic component and method

A prosthetic component suitable for long-term implantation is provided. The prosthetic component includes electronic circuitry and sensors to measure a parameter of the muscular-skeletal system. The prosthetic component comprises a first structure having at least one support surface, a second structure having at least one feature configured to couple to bone. The electronic circuitry and sensors are hermetically sealed within the prosthetic component. Sensors can be used to monitor synovial fluid in proximity to the joint to determine joint health. The prosthetic component can include a temperature sensor, a pH sensor, and an optical sensor. The temperature, pH, color, and turbidity of the synovial fluid can be correlated to a variety of joint conditions. Measurements over time can be analyzed for trends. The temperature, pH, color, and tubidity can be calibrated for the patient. The measurements are compared against this patient reference.

Prosthetic component for monitoring synovial fluid and method

An orthopedic system to monitor a parameter related to the muscular-skeletal system is disclosed. The orthopedic system includes electronic circuitry, a sensor, and a remote system to monitor and measure. The sensor is configured to measure color or turbidity. The electronic circuitry is coupled to and interfaces with the sensor. The electronic circuit includes a transmitter to transmit measurement data from the sensor to the remote system. The orthopedic system is configured to monitor color or turbidity of a fluid in proximity to the muscular-skeletal system. The orthopedic system can transmit a signal when a predetermined color is detected or when the turbidity of the fluid exceeds a predetermined value. Alternatively, the remote system includes a processor and software configured to analyze the measurement data from the sensor and transmit a signal when a predetermined color is detected or when the turbidity of the fluid exceeds a predetermined value.

Methods and systems for stimulation for glial modulation

A system for planning or conducting stimulation includes a display; and a processor that executes instructions configured for: displaying, on the display, a representation of a stimulation effect; obtaining and displaying, on the display, a path for migration of the stimulation effect; receiving a duration or rate for migration of the stimulation effect; and determining a selection of one of more electrodes or optical stimulators for one or more stimulation leads of a stimulation system to produce the stimulation effect and conduct the migration of the stimulation effect along the path according to the duration or rate.

Directional electrical stimulation leads and systems for spinal cord stimulation

An implantable electrical stimulation lead can be used for spinal cord stimulation. Leads with segmented electrodes can be used to provide both medial and lateral stimulation. Multiple leads with segmented electrodes can provide paddle-like stimulation. Leads with bent distal portions can facilitate stimulation of multiple elements of the spinal cord and associated anatomy such as, for example, the dorsal column, dorsal, horn, dorsal root ganglia, and the like.

Methods and systems for stimulation for glial modulation

A system for planning or conducting stimulation includes a display; and a processor that executes instructions configured for: displaying, on the display, a representation of a stimulation effect; obtaining and displaying, on the display, a path for migration of the stimulation effect; receiving a duration or rate for migration of the stimulation effect; and determining a selection of one of more electrodes or optical stimulators for one or more stimulation leads of a stimulation system to produce the stimulation effect and conduct the migration of the stimulation effect along the path according to the duration or rate.

Mutation mimicking compounds that bind to the kinase domain of egfr

This invention is in the fields of cancer therapy. More particularly it concerns compounds which are useful agents for treating cell proliferative disorders, especially those disorders characterized by over activity and/or inappropriate activity of a EGFR, including EGFR-related cancers, particularly for expanding the efficacy of drugs previously developed for this purpose, and for methods of treatments using the compounds for this purpose.

Device and methods to actively control the production of multi-stage polymer production

Devices and methods for actively controlling the production of multistage and multimodal polymers. The device may include a reaction vessel configured to contain a polymer solution and generate polymer reactions in at least two stages as well as one or more detectors configured to monitor at least one reaction characteristic of the polymer solution contained in the reaction vessel. The device may further include a controller coupled with the reaction vessel and the one or more detectors, the controller configured to actively control the development of a predetermined reaction characteristic by modifying at least one process control variable based on the at least one reaction characteristic monitored by the detector.

Photochromic-electrochromic compositions

E. coli fimh mutants and uses thereof

This disclosure relates to the design of E. coli mutated FimH polypeptides that result in improved biochemical properties and immunogenicity, compositions comprising such polypeptides, and uses thereof.

Amantadine compositions and methods of use

Methods of nighttime administration of amantadine to reduce sleep disturbances in patient undergoing treatment with amantadine are described, as well as compositions of extended release amantadine that are suitable for nighttime administration.

Herbicidal compositions

The present invention relates to compositions for protecting crop of useful plants from the harmful effects of certain pyridine derivative herbicides as well as methods for protecting crops of useful plants from the harmful effects of these herbicides and methods for combating weeds in crops of useful plants.

Diluted microemulsions with low surface tensions

Compositions relating to microemulsions or diluted microemulsions for treating gas wells having wellbores and methods related to treating gas wells having wellbores using the same are generally provided. In some embodiments, the microemulsions or diluted microemulsions have an especially low surface tension at a gas well bottom hole temperature and pressure.

Epoxy primer layer for fuser belts

A fuser belt comprising in order a substrate comprising a polyimide substrate, an epoxy primer layer comprising an epoxy resin having the following structure: where R 1 and R 2 are each independently H or an alkyl group containing 1 to about 4 carbon atoms, and R 3 and R 4 are each independently H, F, or an alkyl group containing 1 to about 4 carbon atoms, Z is a carbonyl cross-linking group, and x is an integer from 1 to about 10 and said epoxy priming layer also comprising an anhydride crosslinking agent cyclic mono anhydride or dianhydride having the following structure: and mixture thereof where R is an alkyl group containing 6 to about 8 carbon atoms and a toner release layer comprising a silsesquioxane.

Antibodies against clostridium difficile toxins and methods of using the same

Monoclonal antibodies, or antigen-binding fragments thereof, that bind to Clostridium difficile (C. difficile) toxin A or toxin B and methods of using the same to detect or treat C. difficile infections and/or C. difficile-associated disease.

Manually operated locking device for car bodies and containers

High level recombinant protein production using conditional helper-free adenovirus vector

The present invention relates to methods and compositions involving an improved recombinant transfer vector for introducing a DNA sequence, encoding a recombinant protein, into an adenovirus genome in generating recombinant adenovirus. Recombinant protein production, in cells infected with the recombinant adenovirus, can approach levels as high as 15-20% of total cellular proteins. The improved transfer vector includes an expression cassette comprising sequentially a transcription promoter, a high efficiency leader, at least one splicing signal, an enhancer-like sequence, a cloning site and a plurality of polyadenylation sites.

Wipe dispenser

A dispenser for the wipes is described suitable for use in a shower environment, utilizing a shell having opposed top and bottom ends and, in a preferred embodiment, a support device connected to the shell for securing the dispenser to an outside surface. In another embodiment, the dispenser prevents water spray from the shower from contaminating the wipes contained therein. The bottom end has a dispensing slot with a length dimension greater than a width dimension and a finger-access opening to enable the user to urge wipes in the direction of the dispensing slot. The inventive wipe dispenser also is conveniently refilled with disposable wipes.

Wipe dispenser

A dispenser for the wipes is described suitable for use in a shower environment, utilizing a shell having opposed top and bottom ends and, in a preferred embodiment, a support device connected to the shell for securing the dispenser to an outside surface. In another embodiment, the dispenser prevents water spray from the shower from contaminating the wipes contained therein. The bottom end has a dispensing slot with a length dimension greater than a width dimension and a finger-access opening to enable the user to urge wipes in the direction of the dispensing slot. The inventive wipe dispenser also is conveniently refilled with disposable wipes.

Wipe dispenser

A dispenser for the wipes is described suitable for use in a shower environment, utilizing a shell having opposed top and bottom ends and, in a preferred embodiment, a support device connected to the shell for securing the dispenser to an outside surface. In another embodiment, the dispenser prevents water spray from the shower from contaminating the wipes contained therein. The bottom end has a dispensing slot with a length dimension greater than a width dimension and a finger-access opening to enable the user to urge wipes in the direction of the dispensing slot. The inventive wipe dispenser also is conveniently refilled with disposable wipes.

PANOS DISPENSER

Un dispensador para panos adecuado para ser utilizado en la ducha, que utiliza una estructura que tiene un extremo superior y un extremo inferior que son opuestos, y en una realización preferida, un dispositivo de soporte conectado a la estructura para asegurar el dispensador en una superficie externa. En otra realización, el dispensador impide que la lluvia de la ducha contamine los panos contenidos en el mismo. El extremo inferior tiene una ranura de suministro que tiene una longitud que es mayor que el ancho y una abertura de acceso para los dedos para permitir que el usuario impulse los panos en dirección a la ranura de suministro. El dispensador de panos también se recarga convenientemente con panos descartables. A pan dispenser suitable for use in the shower, which uses a structure having an upper end and a lower end that are opposite, and in a preferred embodiment, a support device connected to the structure to secure the dispenser on a surface external In another embodiment, the dispenser prevents the shower rain from contaminating the cloths contained therein. The lower end has a supply slot that is longer than the width and a finger access opening to allow the user to propel the loops in the direction of the supply slot. The bread dispenser is also conveniently recharged with disposable buns.

Wipe refill kit

A disposable wipes refill kit (100, 110) is described which comprises an outer container (44) and a plurality of individual stacked wipes (40). In one embodiment the outer container has opposed end panels and a peripheral surface interposed between the two end panels (43), wherein at least one of the end panels is openable exposing a part of the leading edge (42) of a plurality of wipes. In a second embodiment, the outer container has an upper portion (60) extending from the base and being detachable along a line of weakness (46) which exposes a part of the leading edge of a plurality of wipes.

Amino acid substituted molecules

The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids. Certain aspects of the invention include methods of adding a chemical moiety to a target molecule, and the compositions resulting therefrom. Certain aspects of the invention also relate to kits for identifying, modifying and producing modified target molecules described herein.

Method and plant for the manufacture of rfid devices

A continuous laminar support (5) is driven in accordance with successive handling steps, mutually interspersed with stop phases, along a processing line (1) comprising a plurality of work stations (2) each carrying at least one applicator (16) of a constructive component of an RFID device on the laminar support (5). In conjunction with each handling step, at least one RFID module (23) in correspondence of at least a module application station (9) and at least one antenna (29) in correspondence of at least one antenna application station (10a, 10b) are applied on the laminar support (5). In conjunction with each of the stop phases, at least in one of the work stations (2) the position of a reference index (45) arranged on the laminar support (5) is detected, and the constructive component of the RFID device is applied in a predetermined position with respect to said reference index (45).

Method and apparatus for applying antennas for rfid devices on a laminar support

In a line for the production of RFID devices, an apparatus for the application of antennas (30) comprises an applicator (16) slidably guided relative to a support bracket (32) parallel to a vertical movement axis (Z), and operating in an elastic thrust relationship against a laying plane (13) bearing a laminar support (5). Guiding members (38,39) lead an terminal portion (31 a) of an elongated element (31) made of conductive material in an application position between the applicator (16) and the laying plane (13). Movement devices (12) translate the applicator (16) according to respectively orthogonal movement axes, including said vertical movement axis (Z), for depositing the elongated element (31) according to a desired path on the laminar support (5). Translations along the vertical movement axis (Z) determine the selective activation/deactivation of a braking element (42) and a cutting member (41) carried by a rocker arm (40) associated to the applicator (16) and operating on the terminal portion (31a).

Method and apparatus for applying antennas for RFID devices on a laminar support

An apparatus for the application of antennas comprises an applicator slidably guided relative to a support bracket parallel to a vertical movement axis, and operating in an elastic thrust relationship against a laying plane bearing a laminar support. Guiding members lead an terminal portion of an elongated element made of conductive material in an application position between the applicator and the laying plane. Movement devices translate the applicator according to respectively orthogonal movement axes, including said vertical movement axis, for depositing the elongated element according to a desired path on the laminar support. Translations along the vertical movement axis determine the selective activation/deactivation of a braking element and a cutting member carried by a rocker arm associated to the applicator and operating on the terminal portion.

Surface-based tagmentation

Presented herein are methods and compositions surface-based tagmentation. In particular embodiments, methods of preparing an immobilized library of fragmented and tagged DNA molecules on a solid surface are presented. In particular embodiments, the solid surface comprises immobilized transposomes in a dried format, suitable for reconstitution upon contact with liquid, such as a liquid sample.

Turbine blade platform seal

(57)【要約】 【課題】 タービンブレードプラットホームシールを提 供する。 【解決手段】 ガスタービンエンジンのタービンブレー ド用シールが開示されている。このシールは、２つの小 部分を備えたシール部分を有していて、上記小部分は、 長手方向に互いにオフセットしており、上記シールが、 上記長手方向にオフセットした内側プラットホーム面を 有する隣接したタービンブレードを互いにシールしてい る。上記シール小部分の間のこのオフセットは、概ね上 記プラットホーム内側面の間のオフセット量に対応して いる。

Process for forming fluoroelastomer composite material containing polydialkylsiloxane particles

In a process for forming a fluoroelastomer composite material for use in preparing an image member containing a substrate, a curable fluorocarbon elastomer is combined with preformed polysiloxane particles in an organic solvent, thereby forming a composite mixture. Milling the composite mixture produces a uniform coating dispersion of the fluoroelastomer composite material in the organic solvent.

Method for producing micron sized silicone rubber particles

A method for preparing silicone particles having an average particle size of 6 microns or less, said method comprising the following steps. First, a multifinctional vinyl terminated polysiloxane is mixed with a hydride terminated polysiloxane, surfactant, and polymerization catalyst under ambient conditions. This mixture is then dispersed in water under ambient conditions. The dispersion is the heated to cure the silicone. Afterwards the dispersion is broken and the particles are washed.

Blended polymer fets

Blended polymer FETs

A method for forming a semiconductor body, the method comprising: forming a mixture of an organic semiconducting material and a binder material; causing the semiconducting material to at least partially solidify; and causing the binder material to crystallize in such a way as to cause the semiconducting material to at least partially segregate from the binder material.

Blended polymer FETs

A method for forming a semiconductor body, the method comprising: forming a mixture of an organic semiconducting material and a binder material; causing the semiconducting material to at least partially solidify; and causing the binder material to crystallize in such a way as to cause the semiconducting material to at least partially segregate from the binder material.

Blended polymer fets

A method for forming a semiconductor body, the method comprising: forming a mixture of an organic semiconducting material and a binder material; causing the semi conducting material to at least partially solidify; and causing the binder material to crystallize in such a way as to cause the semi conducting material to at least partially segregate from the binder material.

Blended polymer fets

A method for forming a semiconductor body, the method comprising: forming a mixture of an organic semiconducting material and a binder material; causing the semiconducting material to at least partially solidify; and causing the binder material to crystallize in such a way as to cause the semiconducting material to at least partially segregate from the binder material.

Method for shaping metal sheets

Several rows of slits offset relative to one another are introduced into the surface of the metal sheet (1). Their orientation and positioning is such that during subsequent shaping, a metal grid with transverse ribs is produced. Subsequently the sheet (1) is shaped and the slits are widened to produce spaces (3) separated from one another by the ribs of the metal grid.

LOCK FOR VEHICLE BOXES.

LOCK FOR VEHICLE BOXES.

L'invention concerne une articulation logée et soutenue par un profilé métallique (1) avec lequel les dossiers du caisson de véhicule pourront être ancrés qui comprend un levier d'actionnement (2) connexe à l'une des extrémités du profilé (1) par des moyens adaptés, coopérant avec un ressort de (7) et connexe à l'autre extrémité par une bielle (5) (6) à un chariot (10) pourvu de goujon(s) saillant(s) pour l'accouplement des dossiers à joindre et chargé par un ressort (22). The invention relates to a joint housed and supported by a metal section (1) with which the backrests of the vehicle box can be anchored, which comprises an actuating lever (2) connected to one end of the section (1) by suitable means, cooperating with a spring of (7) and connected at the other end by a connecting rod (5) (6) to a carriage (10) provided with projecting pin (s) for coupling the backrests to be joined and loaded by a spring (22).

LIPOSOMIAL FORMULATION FOR TOPICAL OR VAGINAL ADMINISTRATION OF DRUGS.

Fluorocarbon thermoplastic materials cured with organic primary amines

A composition comprising a fluorocarbon thermoplastic random copolymer having the subunits of: —(CH 2 CF 2 ) x -, —(CF 2 CF(CF 3 )) y -, and —(CF 2 CF 2 ) z -, wherein x is from 1 to 40 or 60 to 80 mole percent, z is greater than 40 to no more than 89 mole percent, and y is such that x+y+z equals 100 mole percent; wherein the fluorocarbon thermoplastic random copolymer is crosslinked with an organic primary amine. The composition may be formed by curing an aqueous coated composition of the fluorocarbon thermoplastic random copolymer and a water soluble organic primary amine, such as triethylenetetraamine (TETA). A fuser member comprises a substrate having an outer substrate surface, and an outer layer disposed over the outer substrate surface where the outer layer comprises such a composition.

Marking silk products

A process is provided for identifying a production and/or commercial history of a silk fiber or a product made therefrom.

Tagmentation using immobilized transposomes with linkers

The present disclosure relates to methods, compositions, and kits for treating target nucleic acids, including methods and compositions for fragmenting and tagging nucleic acid (e.g., DNA) using transposome complexes bound to a solid support.

Port with piercing means

A port is provided for use with a wound dressing. The port has piercing means to change the configuration of wound dressing for use in a pressure gradient wound therapy apparatus or for use without a pressure gradient wound therapy apparatus. The port is for connecting a non-atmospheric pressure source to a wound dressing. It comprises a first aperture configured to connect to the non-atmospheric pressure source; and a wound dressing contact surface. The wound dressing contact surface includes a second aperture in fluid communication with the first aperture and configured to allow fluid communication with the wound dressing. The piercing means is configured to pierce the wound dressing as the wound dressing contact surface of the port is applied to the wound dressing.

Conservative transposition of contiguity

Un método para preparar una genoteca de fragmentos de ADN codificados con códigos de barras de un ácido nucleico diana que comprende: a. poner en contacto un ácido nucleico diana con una pluralidad de complejos de transposomas, cada complejo de transposomas comprende: transposones y transposasas, en donde los transposones comprenden cadenas transferidas y cadenas no transferidas, en donde al menos uno de los transposones del complejo de transposomas comprende una secuencia de adaptadores capaz de hibridar a una secuencia de captura complementaria; b. fragmentar el ácido nucleico diana en una pluralidad de fragmentos e insertar una pluralidad de cadenas transferidas en el extremo 5' de al menos una cadena de fragmentos mientras se mantiene la contigüidad del ácido nucleico diana; c. poner en contacto la pluralidad de fragmentos del ácido nucleico diana con una pluralidad de soportes sólidos, cada uno de los soportes sólidos en la pluralidad comprende una pluralidad de oligonucleótidos inmovilizados, cada uno de los oligonucleótidos comprende una secuencia de captura complementaria y una primera secuencia de códigos de barras, y en donde la primera secuencia de códigos de barras de cada soporte sólido en la pluralidad de los soportes sólidos difiere de la primera secuencia de códigos de barras de otros soportes sólidos en la pluralidad de soportes sólidos; d. transferir la información de la secuencia de códigos de barras a los fragmentos del ácido nucleico diana, produciendo así una genoteca de fragmentos bicatenarios, en donde al menos una cadena está marcada en el extremo 5' con el primer código de barras, en donde al menos dos fragmentos del mismo ácido nucleico diana reciben información idéntica de códigos de barras. A method of preparing a library of barcode-encoded DNA fragments of a target nucleic acid comprising: a. contacting a target nucleic acid with a plurality of transposome complexes, each transposome complex comprises: transposons and ...

Animal and human anti-malarial agents

Composition and process for color hair

A composition, kit and process for dyeing hair fibers in a manner which inhibits color loss during subsequent shampooing involving contacting the hair fibers with a composition containing: (a) at least one polyamine having at least two amino groups; (b) at least one anionic silicone; and (c) at least one dye component chosen from a direct dye and an oxidation dye, and wherein the dyed hair fibers inhibit color loss resulting from subsequent shampooing of the dyed hair fibers.

Low voc hair sprays with improved spray characteristics

Hair spray compositions in aqueous based systems containing 80% or less of volatile organic compounds exhibit a loss of spray performance properties resulting from viscosity and surface tension increases. The addition of 0.6 to 5% of one or more hydrophobic additives selected from the group consisting of hexamethyl disiloxane, bisphenyl hexamethicone and isocetyl alcohol improves the spray characteristics by eliminating foaming at the spray actuator and on the hair.

Devices and processes for analysing individual cells

A device for individually analysing cells of interest, comprising (a) a channel for receiving the contents of a cell of interest, wherein the channel has an input end and an output end, and (b) a cell trapping site in proximity to the input end of the channel, wherein (i) the input end of the channel is adapted such that an intact cell of interest cannot enter the channel; and (ii) the channel contains one or more analytical components for analysing the contents of the cell of interest. In use, a cell is applied to the device, where it is trapped by the cell trapping means. The cell cannot enter the channel intact, but its contents can be released in situ to enter the channel's input end. The contents can then move down the channel, towards the output end, and they encounter the immobilised reagents, thereby permitting analysis of the cell contents.

herbicidal compositions

resumo patente de invenção: "composições herbicidas". a presente invenção refere-se a composições para proteger culturas de plantas úteis contra os efeitos nocivos de determinados herbicidas derivados de piridina, bem como métodos para a proteção de colheitas de plantas úteis contra os efeitos prejudiciais desses herbicidas e métodos para combater infestantes em plantas de cultivo úteis patent summary: "herbicidal compositions". The present invention relates to compositions for protecting useful plant crops against the harmful effects of certain pyridine-derived herbicides, as well as methods for protecting useful plant crops from the harmful effects of such herbicides and methods for combating weeds in plants. useful cultivation

Systems and methods for identifying individuals with a sleeping disorder and a disposition for treatment

A system and method includes (i) providing patient data stored in a data repository, (ii) applying a first patient identification algorithm to the patient data to identify an initial group of individuals associated with select physical and health characteristics, (iii) applying a second patient identification algorithm to the patient data associated with the initial group of individuals to identify a narrower subgroup associated with select behavioral characteristics, and (iv) generating patient identifiable information from the patient data to allow for notification. The identification of the initial group is based on a determined likelihood of obstructive sleep apnea (OSA) for individuals meeting or exceeding a first threshold criteria. The identification of the narrower group is based on a determined likelihood of long-term adherence to OSA treatment for individuals meeting or exceeding a second threshold criteria. The notification is of designated entities that one or more of the individuals in the narrower subgroup are preferred individuals for OSA.

Methods and compositions for stimulating the production of hydrocarbons from subterranean formations

Emulsion or microemulsion for treating an oil or gas well having a wellbore are provided, and related methods. In some embodiments, the emulsion or microemulsion comprises an aqueous phase; a surfactant; and a non-aqueous phase comprising a first type of solvent and a second type of solvent. In some embodiments, the first type of solvent is a long chain hydrocarbon. In some embodiments, the second type of solvent is an oxygenated solvent. The emulsion or microemulsion may comprise additional components (e.g., at least one type of co-solvent).

Chlorotoxin conjugates and methods of use thereof

Compositions, formulations and kits comprising chlorotoxin conjugate compounds are provided, including native and modified variants of chlorotoxin peptide conjugated to reporter molecules including fluorescent dyes. Methods of detecting and treating cancers and tumors with chlorotoxin conjugate compounds are also provided, including methods of imaging tumor tissues and cells. Dosing and pharmacokinetic profiles for therapeutic and diagnostic applications using chlorotoxin conjugate compounds are also provided.

Methods for elevation of lipid and cholesterol metabolism

Gas turbine engine shaft break mitigation

A method of controlling a gas turbine engine includes the steps of: detecting a shaft break event in a shaft connecting a compressor of the gas turbine engine to a turbine of the gas turbine engine; and in response to this detection, activating a shaft break mitigation system which introduces a fluid into a gas flow of the gas turbine engine downstream of the turbine, or increases an amount of a fluid being provided into the gas flow of the gas turbine engine downstream of the turbine, whereby the fluid reduces an effective area of a nozzle for the gas flow so as to reduce the mass flow rate of the gas flow through the turbine.

Ice containing particles for use in making frozen ice drinks

A process for preparing ice containing particles by preparing a liquid formulation that includes water, a glass transition temperature (Tg) elevating agent, a sweetener and a surfactant so that the formulation has a Tg of -5°C to -15°C; and spraying the liquid formulation into a cryogenicatmosphere that is at least 10°C below the Tg of the formulation to form a frozen mass to form ice containing particles. These particles can be used for a variety of purposes but preferably are used for forming frozen ice drinksina simple, rapid and convenient manner. This is particularly usefulwhen a single serving of such drinks is desired as no special equipment to make the drink is required. The invention also relates to packaging for the ice containing particles and methods of making frozen ice drinks from the ice particles.

Acne treatment powder foundation

Dry powder foundation formulations that include a sustained-release salicylic acid composition, an effective, buffering amount of one or more salicylate ions, and one or more of zinc and titanium oxides, and pigments or colorants, are disclosed. The formulations provide both acne treatment and prevention, and sunblock protection. The formulation can also include other sunblocking or sunscreen agents to prevent photoaging and sunburn, such as avobenzone, and 3-benzophenone, and other cosmetically-acceptable active agents and excipients.

Fluoroelastomer roller for a fusing station

A controlled-modulus fusing station member inclusive of a durable, tough, elastically deformable layer incorporating hollow flexible filler particles. The elastically deformable layer can be a single layer on a substrate, the substrate preferably a core member of a fuser roller or a pressure roller. Alternatively, a protective or gloss control fluoropolymer layer is formed on the elastically deformable layer. The elastically deformable layer is made from a dry formulation inclusive of: a fluoroelastomer powder; microspheres in the form of unexpanded microspheres or expanded microballoons; and solid filler particles including strength-enhancing filler particles and thermal-conductivity-enhancing filler particles. The dry formulation is thermally cured or electron-beam cured.

Sinter powder comprising a heteroxenous alcohol for the production of moulded articles

Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung eines Formkörpers, wobei in Schritt i) eine Schicht eines Sinterpulvers (SP), das unter anderem mindestens einen mehrwertigen Alkohol enthält, bereitgestellt wird und in Schritt ii) die in Schritt i) bereitgestellte Schicht belichtet wird. Des Weiteren betrifft die vorliegende Erfindung ein Verfahren zur Herstellung eines Sinterpulvers (SP) sowie ein Sinterpulver (SP) erhältlich nach diesem Verfahren. Außerdem betrifft die vorliegende Erfindung die Verwendung des Sinterpulvers (SP) in einem Sinterverfahren sowie Formkörper, erhältlich nach dem erfindungsgemäßen Verfahren. The present invention relates to a method for producing a shaped body, a layer of a sintered powder (SP), which contains, inter alia, at least one polyhydric alcohol, is provided in step i) and the layer provided in step i) is exposed in step ii). Furthermore, the present invention relates to a method for producing a sintered powder (SP) and a sintered powder (SP) obtainable by this method. In addition, the present invention relates to the use of the sintered powder (SP) in a sintering process and moldings obtainable by the process according to the invention.

Personal cleansing system

A personal cleansing system for substantially dry wiping articles is described suitable for use in a shower environment, utilizing a shell enclosing the wiping articles having a dispensing slot formed along the shell, a closure means, and a support device secured to the shell.

Contiguity preserving transposition

Sample analyser.

Se proporcionan procedimientos para analizar una pluralidad de diferentes muestras. El procedimiento comprende los pasos de: a) aplicar las muestras a un soporte, al cual un componente analítico se inmoviliza; y b) permitir que las muestras interactúen con el componente analítico, de esta forma permitiendo el análisis de las muestras. Las muestras se aplican en el paso a) a diferentes áreas del soporte para producir una configuración espacial de muestras en el soporte. La configuración espacial de las muestras se mantiene en el paso b), de esta forma permitiendo que los resultados de los análisis se comparen con las muestras individuales.

Processes for the preparation of pharmaceutical compositions containing bromocriptine having high stability and related products

Processes for the preparation of bromocriptine tablets or capsules wherein the active ingredient is protected by inclusion in an excipient or by separated granulation of the excipients and mixing granulate wiht a mixture of the active ingredient and a excipient having low moisture content.

Methods for treating polymicrobial infections

Methods for detecting and treating polymicrobial infections, wherein a mixed population of microbes (e.g., bacteria) are present in a patient sample and the microbes are not first isolated from the sample. For example, the present invention describes specific polymicrobial infections and methods of treating said infections, wherein a particular antibiotic or a group of antibiotics are selected based on the composition of the polymicrobial infections.

Sintered powder containing a near-infrared reflector for producing moulded bodies

The invention relates to a method for producing a moulded body, according to which, in step i), a layer of a sintered powder (SP) containing at least one near-infrared reflector, inter alia, is provided, and in step ii), the layer provided in step i) is exposed. The invention also relates to a method for producing a sintered powder (SP), to the sintered powder (SP) that can be produced by said method, and to the use of a near-infrared reflector in a sintered powder (SP). The invention further relates to a moulded body that can be produced by the method according to the invention.

Vision guidance systems and methods for aircraft

Systems and methods useful in providing equivalent visual operation (EVO) for the flight crew of an aircraft independent of the actual outside weather and visibility conditions through the use of synthetic vision (SV) and enhanced vision (EV) technologies are described. The systems and methods described herein can contribute toward gaining an operational credit that can expand the operational capabilities of an aircraft. The systems and methods described herein can provide relatively simple and intuitive solutions for activating and operating such systems.

METHOD FOR THE CALIBRATION OF PNEUMATIC ACTUATORS AND ACTUATED CALIBRATION ACTUATOR.

Human metapneumovirus vaccines

The present disclosure provides antigenic prefusion hMPV F polypeptides, nucleic acid sequences (e.g., RNA sequences, e.g., mRNA sequences) encoding prefusion hMPV F polypeptides, compositions comprising antigenic prefusion hMPV F polypeptides, compositions comprising nucleic acid sequences encoding prefusion hMPV F polypeptides, and hMPV vaccines.

Respiratory pressure therapy system

Apparatus and methods provide compliance management tools such as for respiratory pressure therapy. In some versions, a respiratory pressure therapy system may include one or more processors, such as of a data server, configured to communicate with a computing device and/or a respiratory pressure therapy device. The respiratory pressure therapy device may be configured to deliver respiratory pressure therapy to a patient for a session. The computing device may be associated with the patient. The processor(s) may be further configured to compute a therapy quality indicator of the session from usage data relating to the session. The therapy quality indicator may be a number derived from contributions of a plurality of usage variables for the session in the usage data. The processor(s) may be further configured to present, such as by transmitting, the therapy quality indicator to the computing device. The therapy quality indicator may promote patient compliance.

Chimeric antigen receptor

The present invention is directed to a nucleic acid molecule comprising a polynucleotide sequence encoding a chimeric antigen receptor comprising (a) an anti-CLEC14A binding domain, (b) a transmembrane domain and (c) an intracellular signalling domain; wherein said anti-CLEC14A binding domain is capable of binding to the C- type lectin domain of CLEC14A. The invention further provides a chimeric antigen receptor encoded by the nucleic acid molecule, a vector comprising the nucleic acid molecule, a cell comprising the nucleic acid molecule, vector or CAR and the therapeutic use of the nucleic acid, vector or cell, particularly in treating CLEC14A expressing conditions.

Composition and process for coloring hair

A composition, kit and process for dyeing hair fibers in a manner which inhibits color loss during subsequent shampooing involving contacting the hair fibers with a composition containing: (a) at least one polyamine having at least two amino groups; (b) at least one anionic silicone; and (c) at least one dye component chosen from a direct dye and an oxidation dye, and wherein the dyed hair fibers inhibit color loss resulting from subsequent shampooing of the dyed hair fibers.