07-03-1990 дата публикации
Номер: EP0356673A2
Object of the invention are 5,6,7,8-tetrahydroimidazo [1.5-a] pyridines having the following formula (I) wherein W is a) a 2-naphthyl or 1- or 2- or 9-anthryl radical wherein each benzene ring is unsubstituted or substituted by a substituent chosen from (a₁)halogen, C₁-C₄ alkyl, aryl, aryl-C₁-C₄ alkyl, hydroxy, C₁-C₄ alkoxy aryloxy, aryl-C₁-C₄ alkoxy, formyloxy, C₂-C₅ alkanoyloxy, aroyloxy, mercapto,C₁-C₄ alkylthio, arylthio, aryl-C₁-C₄ alkylthio, C₁-C₄ alkylsulfonyl,arylsulfonyl, C₂-C₅ alkanoylthio, C₂-C₅ alkanoylamino, aroylamino, C₂-C₅ alkanoyl, aroyl,carboxy, C₂-C₅ alkoxycarbonyl, cyano, nitro, mono- or di-(C₁-C₄ alkyl) carbamyl, amino and mono- (C₁-C₄ alkyl) amino (a₂) di-(C₁-C₄ alkyl) amino, morpholino, piperazino and C₁-C₄ alkyl--N-substituted piperazino, and (a₃) a quaternary ammonium radical which is a radical as defined above under (a₂) having a or a further C₁-C₄ alkyl group as the fourth substituent on the nitrogen atom; or b) a pyridyl, pyrazinyl , pyrimidyl or pyridazinyl ring wherein each said ring is unsubstituted or substituted by a substituent chosen from (a₁) to (a₃) above; and the pharmaceutically acceptable salts thereof, which are aromatase inhibitors.
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