COIL OF ALUMINIUM ALLOY VEHICLE MOULDS COMPRISING a REASON FOR STYLE, PROCESS Of OBTAINING SUCH a WHEEL AND MOULD USES BY the PROCESS

COIL OF ALUMINIUM ALLOY VEHICLE MOULDS COMPRISING a REASON FOR STYLE, PROCESS Of OBTAINING SUCH a WHEEL AND MOULD USES BY the PROCESS

La présente invention concerne une roue (1) en alliage d'aluminium, notamment roue de véhicule automobile, comportant au moins un motif de style (2) reproduit sur au moins une face (23) de la roue (1), ledit motif (2) comportant une pluralité de stries successives parallèles (21) s'étendant selon une direction sensiblement radiale par rapport au centre de la roue (1) et dont les dimensions sont du même ordre de grandeur que les tolérances de forme obtenues avec un procédé de moulage basse pression ; la roue (1) et le motif (2) à stries successives (21) étant réalisés par une seule et même opération de moulage basse pression.

IN POSITION AND REVERSAL ADJUSTING DEVICE Of a SEAT OF VEHICULEAUTOMOBILE

METHODS AND SYSTEMS EMPLOYING INTERMEDIATE FREQUENCIES TO CONTROL MULTIPLE GYROSCOPES

IN POSITION AND REVERSAL ADJUSTING DEVICE Of a SEAT OF VEHICULEAUTOMOBILE

DERIVED FROM CALIXARENES, THEIR METHOD OF PREPARATION AND THEIR USE POURL' EXTRACTION OF ACTINIDES AND LANTHANIDES

COIL OF ALUMINIUM ALLOY VEHICLE MOULDS COMPRISING a REASON FOR STYLE, PROCESS Of OBTAINING SUCH a WHEEL AND MOULD USES BY the PROCESS

Batteriegesteuertes Laden einer wiederaufladbaren Batterie

Verfahren und Vorrichtungen zum Wiederaufladen einer wiederaufladbaren Batterie (202) mit Schrittladungsanforderungen, wo der Ladungsstrom reduziert wird, wenn sukzessive Spannungsschwellen der Schrittladungsanforderungen erreicht oder annähernd erreicht werden. Die Batterie (202) ist mit einem Ladungsreduzierungsalgorithmus programmiert, sodass das Batterieladegerät (208) nicht mit batteriespezifischen Informationen programmiert werden muss. Der Ladungsreduzierungsalgorithmus wird in Verbindung mit den Schrittladungsanforderungen und einer Messung von einer oder mehreren Eigenschaften der Batterie verwendet, um einen geeigneten Ladungsstrom als eine Funktion der Zeit zu bestimmen.

Gyroscope e.g. hemispherical resonator gyroscope, controlling system, has gyroscopes outputting intermediate frequency signals with same frequency, and processor processing frequency signals to output directional signal

L'invention concerne des appareils, des systèmes et des procédés permettant de commander une pluralité de gyroscopes en utilisant des fréquences intermédiaires. Les gyroscopes (300) sont configurés pour fonctionner à une même fréquence intermédiaire prédéterminée. A cette fin, la fréquence naturelle de chaque est déterminée, tandis qu'un signal de référence est ajouté au signal de sortie de son gyroscope respectif de façon que la somme de la fréquence naturelle et de la fréquence du signal de référence soit égale à la fréquence intermédiaire prédéterminée. Le signal de sortie venant de chaque gyroscope est transmis à un processeur commun de traitement de données d'inertie, et le processeur de données d'inertie délivre en sortie un signal directionnel. Le signal directionnel comporte une représentation d'angle par rapport à un axe X, un axe Y et un axe Z. Puisque chaque signal délivré par le gyroscope possède une même fréquence, les pertes de données sont diminuées et la précision des données ...

COIL OF ALUMINIUM ALLOY VEHICLE MOULDS COMPRISING a REASON FOR STYLE, PROCESS Of OBTAINING SUCH a WHEEL AND MOULD USES BY the PROCESS

La présente invention concerne une roue (1) en alliage d'aluminium, notamment roue de véhicule automobile, comportant au moins un motif de style (2) reproduit sur au moins une face (23) de la roue (1), caractérisée en ce que le motif (2) comporte une pluralité de stries successives parallèles (21) s'étendant selon une direction sensiblement circonférentielle par rapport au centre de la roue (1) et dont les dimensions sont du même ordre de grandeur que les tolérances de forme obtenues avec un procédé de moulage basse pression ; la roue (1) et le motif (2) à stries successives (21) étant réalisés par une seule et même opération de moulage basse pression.

Directional system receives and processes intermediate frequency signals to output directional signals having same frequency

Des dispositifs, systèmes et procédés destinés à commander la fréquence d'une pluralité de gyroscopes sont décrits. Les gyroscopes (300 ; 500, 600 ; 800, 900, 1000) sont configurés de sorte que chaque gyroscope individuel fonctionne indépendamment des autres et à la même fréquence prédéterminée. Pour accomplir cela, la fréquence naturelle de chaque gyroscope est déterminée, et un signal de référence est ajouté au signal de sortie de son gyroscope respectif, de sorte que la somme de la fréquence naturelle et de la fréquence du signal de référence soit égale à la fréquence prédéterminée. Donc, chaque gyroscope individuel, bien qu'il puisse présenter sa propre fréquence naturelle individuelle, fonctionne de manière autonome à la fréquence prédéterminée.

AMINOPYRONE UND IHRE VERWENDUNG ALS ATM INHIBITOREN

Multipurpose rat cage

A multipurpose rat cage is provided for housing a plurality of different species of rodents therein. The rat cage includes a cage bottom having a plurality of integral side walls, a floor and an open top end. The floor has a length and a width such that the area of the floor is between 80 square inches and a 140 square inches.

HTK-LIGAND

DIALYSEMASCHINEN MIT EINEM BERÜHRUNGSEMPFINDLICHEN BILDSCHIRM ALS BENUTZERSCHNITTSTELLE

FLEISCHPRODUKT MIT JOGURT UND VERFAHREN ZUR SEINER HERSTELLUNG

MANUFACTURE OF MEAT-BASED PRODUCTS

Locator and closure device and method of use

The present invention is directed to a device which is capable of both locating a punctured blood vessel wall and sealing the puncture in the vessel and to the method of using the device as well. In one embodiment, the device includes an elongate deployment member having a sealing element releasably disposed within a distal end thereof, said deployment member being coupled to a first actuator configured to retract said deployment member relative to said sealing element, and an elongated indicator member having a proximal end and a distal end, said indicator member extending through a lumen in said deployment member such that the distal end of said indicator member extends distally of the distal end of the deployment member, and said indicator member being coupled to a second actuator configured to retract said indicator member relative to said deployment member.

Venturi device and method

An improved venturi device for facilitating the mixture of fluid substances, such as wine and air. The device may be combined with a dispensing valve to further promote functionality. The improved venturi device is especially effective in drawing a second fluid into the primary flow of a first fluid, and when combined with a dispensing valve it obviates the need for a venturi independent from a valve to accomplish mixing at low flows and low liquid head pressure.

Cascade refrigeration system with fluoroolefin refrigerant

The present invention relates to a cascade refrigeration system which circulates a refrigerant comprising a fluoroolefin therethrough. The cascade refrigeration system includes a low temperature refrigeration loop and a medium temperature refrigeration loop. The fluoroolefin circulates through either loop, or both. In a particular embodiment, the fluoroolefin circulates through the medium temperature loop. In a particular embodiment, where the cascade refrigeration system includes a first and a second cascade heat exchanger, and a secondary heat transfer loop which extends between the first and second cascade heat exchangers, either the first and/or second refrigerant may be, but need not necessarily be, a fluoroolefin.

Intracellular Delivery of Contrast Agents with Functionalized Nanoparticles

The present invention is directed to compositions and methods for intracellular delivery of a contrast agent with a functionalized nanoparticle.

Compositions and methods comprising magnetic resonance contrast agents

The present invention relates to compositions and methods for imaging with magnetic resonance contrast agents. In particular, the present invention provides targeted contrast agents for selective imaging.

Hydrostatic drive for a machine

A hydrostatic drive including a hydrostatic pump configured to supply a transmission fluid. The hydrostatic drive further includes an axle motor and a drum motor. The axle motor is configured to drive a set of traction wheels and the drum motor is configured to drive a drum. The hydrostatic drive also includes an axle drive line and a drum drive line. The axle drive line and the drum drive line are connected to the axle motor and the drum motor respectively to supply the transmission fluid. A manifold integrally connected to the hydrostatic pump to operatively couple the axle drive line and the drum drive line with the hydrostatic pump.

Robotic surgical control system

The invention involves a system and method for controlling the movements of a multi-axis robot to perform a surgery at least on the spinal area of a human in vivo. The system includes controls and software coding to cause the robot to move in desired patterns to complete the surgery, which may include bone, disc and tissue removal, and may also include insertion of hardware for fusing adjacent bony structures.

Magnetizable abrasive particle and method of making the same

Magnetizable abrasive particles are described comprising ceramic particles having outer surfaces comprising a coating of unsintered polyion and magnetic particles bonded to the polyion. In favored embodiments, the magnetic particles have a magnetic saturation of at least 10, 15, 20, 25, 30, 35, 40, 45 or 50 emu/gram. In another embodiment, an abrasive article is described comprising a plurality of magnetizable abrasive particles as described herein retained in a binder material. Also described are method of making magnetizable abrasive particles and methods of making an abrasive article comprising magnetizable abrasive particles.

Locator and closure device and method of use

The present invention is directed to a method for sealing a puncture in a wall of a lumen of a body comprising the steps of deploying a deployment member of a sealing device through an elastic membrane adjacent the wall of the lumen and the puncture, wherein the sealing device includes a sealing element; positioning the sealing element adjacent the wall of the lumen; retracting the deployment member relative to the sealing element to stretch the membrane away from the wall of the lumen; retracting the deployment member relative to the sealing element to allow the elastic nature of the membrane to force the sealing element against the puncture; and retracting the device from the puncture.

Steam ablation device for treatment of menorrhagia

Disclosed herein is a vapor therapy device for producing intra-uterine tissue effects. The device can include a shaft, including a proximal portion and a distal portion, a fluid-expandable medium, near the distal portion of the shaft, a fluid-delivery conduit, extending between the proximal portion and the distal portion of the shaft, the fluid-delivery conduit comprising an outlet, near the distal portion of the shaft, for delivery of the fluid toward the medium, and an in vivo heat generator, near the distal portion of the shaft, to heat the fluid. A method of treating a patient for menorrhagia with the device can include introducing a medium, in a contracted state, into a patient, delivering a fluid toward the medium to expand the medium in vivo; generating heat in vivo on or near the medium to vaporize the fluid, and exposing a treatment site to the vaporized fluid.

Wind generator rotor connection replacement

Devices, systems, and methods for repair and upgrade of the connection between a winding and a wye ring of a rotating electric machine. The system generally includes a flexible connector having an elongated curved central region. A first end of the flexible connector may be connected to the winding by brazing and a second end of the flexible connector may be connected to the wye ring as a brazed puzzle or dovetail joint. The system may further include a wye ring assembly specifically configured to provide attachment for the flexible connectors.

7-azaindole derivatives

Compounds of the formula (I) in which R, R 1 , R 2 and R 3 have the meanings indicated in Claim 1 , are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumours.

Method and System for Controlling a Cruise Control System

A method for controlling a cruise control system on a vehicle includes identifying a vehicle location and identifying a number of respective cruise control overrides by a driver at the vehicle location. If the number of cruise control overrides by the driver is at least a threshold number of overrides, identifying respective actions by the driver after the cruise control overrides, and creating a profile of the driver behavior associated with the vehicle location based on the respective actions by the driver within a range around the vehicle location after the driver overrode the cruise control.

Photodynamic therapy device and methods of use

A therapy device comprises a shaft extending between proximal and distal portions, a surgical instrument located at the distal portion, a handpiece located at the proximal portion, a treatment end located at the distal end of the surgical instrument that can apply photodynamic therapy (PDT). The treatment end includes an applicator to apply a photosensitizer to a surface of a target tissue and a light emitter that can emit generated phototherapeutic light to activate the photosensitizer to ablate target tissue. A method for providing PDT to the target tissue includes inserting the therapy device into the patent, applying the photosensitizer and phototherapeutic light to a surface of the target tissue, and removing the device from the patient.

Bacteria-targeted magnetic resonance contrast agents

The present invention relates to bacteria-targeted contrast agents for magnetic resonance imaging (MRI). In particular, the present invention relates to bacteria targeted MRI contrast agents that can be used to detect bacteria in vivo or in vitro. In certain embodiments, the contrast agents comprise a metal chelate conjugated to at least two Zn-dipicolylamine groups.

Devices and methods to treat and prevent diverticulitis

A method of treating diverticulitis and the diverticulum by reducing the bioactivity of the diverticulum such that the diverticulum necroses. The devices and methods include placing an endoscopic device within a colonic lumen relative to at least one diverticulum and inverting the diverticulum. Once inverted, the diverticulum is collapsed and sealed. Overtime, the inverted diverticulum will necrose and be absorbed by the body or slough off and be expelled.

In Situ Exfoliation Method to Fabricate a Graphene-Reinforced Polymer Matrix Composite

A method for forming a graphene-reinforced polymer matrix composite by distributing graphite microparticles into a molten thermoplastic polymer phase comprising one or more molten thermoplastic polymers; and applying a succession of shear strain events to the molten polymer phase so that the molten polymer phase exfoliates the graphene successively with each event, until tearing of exfoliated multilayer graphene sheets occurs and produces reactive edges on the multilayer sheets that react with and cross-link the one or more thermoplastic polymers; where the one or more thermoplastic polymers are selected from thermoplastic polymers subject to UV degradation.

Compositions and methods for the treatment of disease associated with trp-p8 expression

Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Tip-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Tip-p8 expression.

Vascular and aortic grafts and deployment tool

A method and deployment tool for implanting a graft in a blood vessel of a patient. The deployment tool may include a mandrel with a dilator tip at a distal end and an inner passage defined through the dilator tip. The tool may also include a graft having a first end and a second end, at least part of which is placed about the mandrel. A sheath may be wrapped about at least part of the graft so that the graft is compressed at least partially against the mandrel by the sheath to an insertion diameter. The graft may be implanted by advancing the deployment tool to insert the first end of the graft through an opening in a wall of the blood vessel, removing the sheath from the graft, and expanding at least the first end of the graft to secure the graft within the blood vessel.

Forceps with intentionally misaligned pin

A forceps having at least a first jaw with a longitudinal axis is disclosed. The first jaw can include a body portion, a first flange, a second flange and a cam pin. The first flange can define a first cam slot with a longitudinal extent along the longitudinal axis. The second flange can be spaced from the first flange a distance transverse to the longitudinal axis of the first jaw and can have a second cam slot. The cam pin, with a longitudinal axis, can be moveably secured within the first cam slot and the second cam slot. A diameter of the cam pin can be less than a width between a first longitudinal edge that defines a first side of each of the first cam slot and the second cam slot and a second longitudinal edge that defines a second opposing side of each of the first cam slot and the second cam slot so that the cam pin is moveably received by both the first cam slot and the second cam slot. With the first jaw pivoted to at least a first position, the cam pin and first flange can be configured such that the first longitudinal edge is contacted by the cam pin but the second longitudinal edge is spaced from the cam pin. The cam pin and second flange can be configured such that the first longitudinal edge is spaced from the cam pin but the second longitudinal edge is contacted by the cam pin.

Economical multi-scale reinforced composites

Disclosed are co-continuous immiscible polymer blends of a polysulfone and a polyaryletherketone optionally reinforced with carbon fiber. A method of preparing such a co-continuous immiscible polymer blend of a polysulfone and a polyaryletherketone reinforced with a carbon fiber is also disclosed.

Building Board with Acoustical Foam

Disclosed is a building board construction that provides enhanced acoustical properties. In one possible embodiment, the board is a gypsum board with opposing facing sheets and an intermediate set gypsum core. An opened celled polymeric sheet is formed within the gypsum core and gives the resulting board enhanced sound absorption. In an alternative embodiment, individual pieces of polymeric foam are used in stead of the polymeric sheet. Also disclosed are various manufacturing methods whereby boards with enhanced acoustical properties can be formed in an continuous process. The various components of the present disclosure, and the manner in which they interrelate, are described in greater detail hereinafter.

Surgical stapler cartridge loading and unloading

An exemplary surgical method includes possessing a loader that holds a curved-tip cartridge, and a surgical stapler that includes an anvil and channel at a distal end thereof; causing at least one of the loader and the channel to move toward the other; as a result of the causing, engaging the loader and the curved-tip cartridge with the channel; and causing at least one of the loader and the channel to move away from the other, such that the curved-tip cartridge remains engaged with the channel. That method further may include actuating the surgical stapler; grasping the unloader; sliding the unloader toward the channel; disengaging the curved-tip cartridge from the channel with the unloader; and withdrawing the unloader away from said channel, wherein the withdrawing causes the curved-tip cartridge to disengage from the channel.

Compositions and methods for reducing fire hazard of flammable refrigerants

The present invention relates to compositions comprising flammable refrigerant, fire hazard-reducing agent, and optionally a lubricant suitable for use in a refrigeration or air conditioning apparatus. Further, the present invention relates to compositions comprising lubricant and fire hazard-reducing agent and methods for reducing flammability of flammable refrigerant, for delivering a fire hazard-reducing agent to a refrigeration or air conditioning apparatus, and for replacing a non-flammable refrigerant with a flammable refrigerant.

Compositions comprising fluoroolefins and uses thereof

The present invention relates to fluoroolefin compositions. The fluoroolefin compositions of the present invention are useful as refrigerants or heat transfer fluids and in processes for producing cooling or heat. Additionally, the fluoroolefin compositions of the present invention may be used to replace currently used refrigerant or heat transfer fluid compositions that have higher global warming potential.

1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl)-3-pentanone refrigerant compositions and uses thereof

The present invention relates to compositions for use in refrigeration and air conditioning systems comprising 1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl)-3-pentanone and at least one chlorocarbon, alcohol, ketone, ether, ester, N-(difluoromethyl)-N,N-dimethylamine, 1,1,1,2,2-pentafluoro-2-[(pentafluoroethyl)thio]ethane or mixtures thereof, and which are also useful in systems employing a centrifugal compressor The compositions of the present invention may be azeotropic or near azeotropic and are useful in processes for producing refrigeration or heat or as heat transfer fluids.

1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl)-3-pentanone compositions comprising a hydrofluorocarbon and uses thereof

Disclosed herein are refrigerant and heat transfer fluid compositions comprising 1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl)-3-pentanone and at least one hydrofluorocarbon for use in refrigeration and air conditioning systems employing a centrifugal compressor. The compositions may be azeotropic or near-azeotropic.

1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl)-3-pentanone refrigerant and heat transfer compositions comprising a fluoroether

Compositions of 1.1.1,2,2,4,5,5,5-nonafluoro-4 (trifluoromethyl)-3 pentanone can be used in heat transfer refrigeration and air conditioning systems. The compositions may be in combination with fluoroethers. The compositions may be azeotropic or near azeotropic.

1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl)-3-pentanone compositions comprising a hydrofluorocarbon and uses thereof

1,1,1,2,2,4,5,5,5-Nonafluoro-4-(trifluoromethyl)-3-pentanone refrigerant compositions comprising a hydrocarbon and uses thereof

Disclosed herein are refrigerant and heat transfer fluid compositions comprising 1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl)-3-pentanone and at least one hydrocarbon. These compositions are useful in refrigeration and air conditioning systems that employ a centrifugal compressor. Also disclosed herein are azeotropic or near azeotropic refrigerant and heat transfer fluid compositions comprising 1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl)-3-pentanone and at least one hydrocarbon.

Umbrella catheter

Abrasive particles, abrasive articles, and methods of making and using the same

Nucleic acid mediated electron transfer

The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.

Nucleic acid mediated electron transfer

The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.

Nucleic acid mediated electron transfer

The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of the nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes. Hybridization assays employing these complexes are disclosed.

Robotic surgical system

The present invention provides an apparatus, system and method for providing robotically assisted surgery that involves the removal of bone or non-fibrous type tissues during a surgical procedure. The system utilizes a multi-axis robot having a reciprocating tool that is constructed and arranged to remove hard or non-fibrous tissues while leaving soft tissues unharmed. The multi-axis robot may be controlled via computer or telemanipulator, which allows the surgeon to complete a surgery from an area adjacent to the patient to thousands of miles away.

Method and apparatus for controlling and adjusting the intensity profile of a laser beam employed in a laser welder for welding polymeric and metallic components

A method and apparatus is provided for forming a fusion bond between two materials such as two components of a catheter. The method begins by forming a bond site by positioning a portion of a first body with respect to a portion of a second body so that a fusion bond site is formed. A laser beam is generated that has an intensity profile across its width. The laser beam is directed onto at least a portion of the first and second bodies within the bond site so that a fusion zone having an increased temperature is formed. After the laser beam is generated, the intensity profile of the laser beam that is directed onto the bond site is controllably adjusted by an optical element such as a dynamically-adjustable beam shaping element.

Seamless, maskless lithography system using spatial light modulator

The invention is a seamless, projection lithography system that eliminates the need for masks through the use of a programmable Spatial Light Modulator (SLM) with high parallel processing power. Illuminating the SLM with a radiation source (1) provides a patterning image of many pixels via a projection system (4) onto a substrate (5). The preferred SLM is a Deformable Micromirror Device (3) for reflective pixel selection using a synchronized pulse laser. An alternative SLM is a Liquid Crystal Light Valve (LCLV) (45) for pass-through pixel selection. Electronic programming enables pixel selection control for error correction of faulty pixel elements. Pixel selection control also provides for negative and positive imaging and for complementary overlapping polygon development for seamless uniform dosage. The invention provides seamless scanning motion by complementary overlap to equalize radiation dosage, to expose a pattern on a large area substrate (5). The invention is suitable for rapid prototyping, flexible manufacturing, and even mask making.

オンコスタチンｍを使用したヒト内皮細胞におけるインターロイキン６の合成を誘導する方法

(57)【要約】 【解決手段】 最近発見されたサイトカインであるオン コスタチンＭを使用した、内皮細胞の免疫原性、繊維素 溶解活性、増殖およびサイトカイン合成を制御する方 法、内皮細胞の増殖を阻害する方法ならびにヒト内皮細 胞におけるIL-6の合成を誘導する方法を提供する。 【効果】 上記の方法においては、成熟型、ハイブリッ ド型、修飾型および末端切断型のオンコスタチンＭなら びにオンコスタチンＭの類似体を使用することができる ため、内皮細胞の増殖やサイトカインの合成の制御をは じめ、血管内皮疾患を含む各種のヒトの疾患の治療、悪 性新生物の治療などにおいて有用である。

SCRAP RESISTANT CURABLE COATING COMPOSITION

Esta presente se refiere a una composicion curable que comprende una solucion de solvente de una mezcla que comprende: i) por lo menos un polímero acrílico hidroxi-funcional; y ii) opcionalmente, por lo menos un diluyente reactivo de poliol de bajo peso molecular; iii) por lo menos un poliisocianato; iv) un silano amino-funcional; v) un catalizador metálico, tal como un compuesto de estano, para acelerar la reaccion de isocianato/hidroxilo; y vi) un ácido de bajo punto de ebullicion. This refers to a curable composition comprising a solvent solution of a mixture comprising: i) at least one hydroxy-functional acrylic polymer; and ii) optionally, at least one low molecular weight polyol reactive diluent; iii) at least one polyisocyanate; iv) an amino-functional silane; v) a metal catalyst, such as a stannous compound, to accelerate the isocyanate / hydroxyl reaction; and vi) a low boiling acid.

Polymeric/carbon composite materials for use in medical devices

The invention provides implantable or insertable medical devices, which contain one or more composite regions. These composite regions, in turn, contain polymer and carbon particles. Also, the invention provides composite materials for use in a medical device containing styrene-isobutylene copolymer and carbon nanotubes.

Penton base protein and methods of using same

A recombinant adenovirus comprising a chimeric penton base protein, which includes a nonpenton base sequence, and a therapeutic gene, a method of gene therapy involving the use of such adenovirus, and adenoviral transfer vectors for the generation of such recombinant adenovirus are provided.

Stabilized polyester based compositions

Stabilized polyester based compositions

於此提供有一種以聚酯或聚酯共聚物為基底之組合物，例如以聚乳酸為基底之組合物。前述以聚酯或聚酯共聚物為基底之組合物可包括有塑化劑，諸如以醚為基底、以酯為基底以及/或以醚-酯為基底之塑化劑。

Stent with embedded material

An endoprosthesis such as a stent is composed of a metal or ceramic, such as Irox, embedded in the stent material.

Stent with embedded material

An endoprosthesis such as a stent is composed of a metal or ceramic, such as Irox, embedded in the stent material.

Binding acceleration techniques for the detection of analytes

The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.

Printed circuit boards with monolayers and capture ligands

The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.

Apparatus and method for analyzing a fluid that includes a liquid phase, contained in a tubular conduit

Apparatus and methods for the flow analysis of multiphase fluids including a liquid phase in a tubular conduit use Stoneley waves by exciting and detecting sonic wave energy in the tubular conduit. Information about the Stoneley mode component is obtained in one approach by using techniques that excite only the Stoneley mode together with certain other well behaved wave types, and then compensating for the latter. Alternatively the Stoneley arrival is specifically identified in the detected waveforms. Embodiments are described for: determining the flow rate of a liquid; detecting the presence or absence of gas in a liquid; determining the composition by volume of the dispersed phases in a multiphase fluid; determining the size distribution of bubbles in a multiphase fluid; and determining the velocity of slugs in a multiphase fluid.

Vent cap with electrolyte drainage and explosion-preventing properties

Covalent conjugates of graphene nanoparticles and polymer chains and composite materials formed therefrom

A method for forming a graphene-reinforced polymer matrix composite is disclosed. The method includes distributing graphite microparticles into a molten thermoplastic polymer phase; and applying a succession of shear strain events to the molten polymer phase so that the molten polymer phase exfoliates the graphite successively with each event until at least 50% of the graphite is exfoliated to form a distribution in the molten polymer phase of single- and multi-layer graphene nanoparticles less than 50 nanometers thick along the c-axis direction.

Use of graphene-polymer composites to improve barrier resistance of polymers to liquid and gas permeants

A packaging material comprising a graphene-reinforced polymer matrix composite (G-PMC) is disclosed. The packaging material has improved barrier resistance to gas and liquid permeants. Also disclosed is a method of improving barrier resistance of a polymer to a permeant, the method comprising forming a graphene-reinforced polymer matrix composite within the polymer. The packaging material may be used for packaging food, drug, perfume, etc. and to make various containers.

In situ exfoliation method to fabricate a graphene-reinforced polymer matrix composite

A method for forming a graphene-reinforced polymer matrix composite by distributing graphite microparticles into a molten thermoplastic polymer phase comprising one or more molten thermoplastic polymers; and applying a succession of shear strain events to the molten polymer phase so that the molten polymer phase exfoliates the graphene successively with each event, until tearing of exfoliated multilayer graphene sheets occurs and produces reactive edges on the multilayer sheets that react with and cross-link the one or more thermoplastic polymers; where the one or more thermoplastic polymers are selected from thermoplastic polymers subject to UV degradation.

Graphene-reinforced polymer matrix composites

A graphene-reinforced polymer matrix composite comprising an essentially uniform distribution in a thermoplastic polymer of about 10% to about 50% of total composite weight of particles selected from graphite microparticles, single-layer graphene nanoparticles, multi-layer graphene nanoparticles, and combinations thereof, where at least 50 wt % of the particles consist of single- and/or multi-layer graphene nanoparticles less than 50 nanometers thick along a c-axis direction. The graphene-reinforced polymer matrix is prepared by a method comprising (a) distributing graphite microparticles into a molten thermoplastic polymer phase comprising one or more matrix polymers; and (b) applying a succession of shear strain events to the molten polymer phase so that the matrix polymers exfoliate the graphite successively with each event until at least 50% of the graphite is exfoliated to form a distribution in the molten polymer phase of single- and multi-layer graphene nanoparticles less than 50 nanometers thick along a c-axis direction.

Atraumatic clamp for vascular surgery

Atraumatic surgical clamp

Interchangeable probe tips for calculi fracture

A device for acoustic calculi fracture can include an acoustically-transmissive elongated probe body extending between a distal portion and a proximal portion and an acoustically-transmissive probe tip that can be selectively user-interchangeable with the probe body. The probe body can have a lumen longitudinally therethrough. A method of fracturing calculi can include interchanging a probe tip with a probe body by a user without requiring an additional tool and transmitting acoustic energy via the probe body and the probe tip to a calculus to at least partially fracture the calculus.

Poly (p-phenyleneneacetylene) light-emitting diodes

Acetylene containing poly(p-phenyleneacetylene) (PPA) - based light-emitting diodes (LEDs) are provided. The LEDs are fabricated by coating a hole-injecting electrode, preferably an indium tin oxide (ITO) coated glass substrate, with a PPA polymer, such as a 2,5-dibutoxy or a 2,5-dihexoxy derivative of PPA, dissolved in an organic solvent. This is then followed by evaporating a layer of material capable of injecting electrons, such as Al or Al/Ca, onto the polymer to form a base electrode. This composition is then annealed to form efficient EL diodes.

Soft tissue anchor and methods and apparatus for securing soft tissue

An apparatus for anchoring in soft tissue generally includes an elongate tensile member adapted to extend within the interior of soft tissue and a first helical anchor configured for insertion within the interior of the soft tissue. The first helical anchor extends along a lengthwise axis of rotation and includes a proximal coil extending around the axis and a distal coil portion ending in a distal tip. The proximal coil defines an outer diameter adjacent to the distal coil portion, and the distal tip is positioned radially outward of the outer diameter. A drive member is coupled with the first helical anchor such that the drive member may be used to rotate the first helical anchor into the soft tissue.

Multiple channel system for a twisted pair telephone wire local loop system

The system ( 50 ) has a subscriber digital filter system ( 54 )connected to the twisted pair telephone wire ( 56 ). A subscriber controller ( 52 ) sends control signals to the subscriber digital filter system ( 54 ). An office digital filter system ( 58 ) is connected to the twisted pair telephone wire ( 56 ). An office controller ( 60 ) sends control signals to the office digital filter system ( 58 ).

Heat stable tetrafluoroethylene-perfluoro(alkyl vinyl ether) copolymers

A tetrafluoroethylene-perfluoro(alkyl vinyl ether copolymer in which heat unstable carbinol end-groups (-CH2OH groups) present have been protected against heat degradation by treating the copolymer with NH3 or NH3 producing compounds.

Implantable medical device including a plurality of lead connection assemblies

An implantable medical device (IMD) may include at least two separate lead connection assemblies, each with electrical connectors for connecting implantable leads to the IMD. In some examples, a IMD may include a first therapy module configured to generate a first electrical stimulation therapy and a second therapy module configured to generate a second electrical stimulation therapy for delivery to the patient. The IMD may include a first lead connection assembly including a first electrical connector electrically coupled to the first therapy module and a second lead connection assembly including a second electrical connector electrically coupled to the second therapy module. In some examples, the first and second lead connection assemblies are distributed around the outer perimeter of the IMD housing.

Implantable medical device including a plurality of lead connection assemblies

An implantable medical device (IMD) may include at least two separate lead connection assemblies, each with electrical connectors for connecting implantable leads to the IMD. In some examples, a IMD may include a first therapy module configured to generate a first electrical stimulation therapy and a second therapy module configured to generate a second electrical stimulation therapy for delivery to the patient. The IMD may include a first lead connection assembly including a first electrical connector electrically coupled to the first therapy module and a second lead connection assembly including a second electrical connector electrically coupled to the second therapy module. In some examples, the first and second lead connection assemblies are distributed around the outer perimeter of the IMD housing.

Binding acceleration techniques for the detection of analytes

The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.

Electronic methods for the detection of analytes

The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.

Adenoviral vectors able to transduce apcs, potential use in immune response generation

The invention provides a method of inducing an immune response in a mammal. The method comprises administering to the mammal an adenoviral vector comprising (a) a subgroup C fiber protein wherein a native coxsackievirus and adenovirus receptor (CAR)-binding site is disrupted, (b) a subgroup C penton base protein wherein a native integrin-binding site is disrupted, and (c) a nucleic acid sequence encoding at least one antigen derived from an infectious agent other than an adenovirus which is expressed in the mammal to induce an immune response.

Targeting adenovirus with use of constrained peptide motifs

The present invention provides a chimeric adenovirus fiber protein, which differs from the wild-type coat protein by the introduction of a nonnative amino acid sequence in a conformationally-restrained manner. Such a chimeric adenovirus fiber protein according to the invention is able to direct entry into cells of a vector comprising the chimeric fiber protein that is more efficient than entry into cells of a vector that is identical except for comprising a wild-type adenovirus fiber protein rather than the chimeric adenovirus fiber protein. The nonnative amino acid sequences encodes a peptide motif that comprises an epitope for an antibody, or a ligand for a cell surface receptor, that can be employed in cell targeting. The present invention also pertains to vectors comprising such a chimeric adenovirus fiber protein, and to methods of using such vectors.

Chimeric adenoviral fiber protein and methods of using same

A recombinant adenovirus comprising a chimeric fiber protein and a therapeutic gene, a method of gene therapy involving the use of such an adenovirus, and an adenoviral transfer vector for the generation of such a recombinant adenovirus are provided.

Detection of analytes using reorganization energy

The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.

Chiller apparatus containing cis-1,1,1,4,4,4-hexafluoro-2 butene and methods of producing cooling therein

Disclosed herein are chiller apparatus containing cis-HFO-1336mzz. These chillers may be centrifugal chillers or positive displacment (e.g., screw) chillers and may comprise flooded evaporators or direct expansion evaporators. Also disclosed herein are methods for producing cooling comprising evaporating cis-HFO-1336mzz in the vicinity of a body to be cooled.

Super elastic alloy guidewire

This invention is a surgical device. It is a guidewire for use in a catheter and is used for accessing a targeted site in a lumen system of a patient's body. The guidewire may be of a high elasticity metal alloy, preferably a Ni-Ti alloy, having specified physical parameters, and is especially useful for accessing peripheral or soft tissue targets. A special variation of the inventive guidewire includes the concept of coating the wire with a one or more lubricious polymers to enhance its suitability for use within catheters and with the interior of vascular lumen. The "necked" guidewire tip also forms a specific variant of the invention.

Optically enhanced instrument with laser fluorescing capabilities

A surgical instrument comprises an elongate body comprising a proximal end portion and a distal end portion and a tissue separator coupled to the distal end portion that is configured to engage sample tissue for collection, wherein the tissue separator is at least partially made from a material that allows light to pass through the tissue separator. A method of collecting biological matter using a tissue retrieval device comprises inserting the tissue retrieval device into anatomy of a patient, guiding a tissue collector of the tissue retrieval device to a target tissue, viewing the target tissue through the tissue collector and collecting biological matter from the target tissue with the tissue retrieval device.

Stimulation of activity of plasminogen activator relative to endothelial cell

(57)【要約】 【解決手段】 最近発見されたサイトカインであるオン コスタチンＭを使用した、内皮細胞の免疫原性、繊維素 溶解活性、増殖およびサイトカイン合成を制御する方 法、内皮細胞の増殖を阻害する方法ならびにヒト内皮細 胞におけるIL-6の合成を誘導する方法を提供する。 【効果】 上記の方法においては、成熟型、ハイブリッ ド型、修飾型および末端切断型のオンコスタチンＭなら びにオンコスタチンＭの類似体を使用することができる ため、内皮細胞の増殖やサイトカインの合成の制御をは じめ、血管内皮疾患を含む各種のヒトの疾患の治療、悪 性新生物の治療などにおいて有用である。

Battery cell

A battery cell including a first wound element conductively coupled directly to a first terminal assembly, a second wound element conductively coupled directly to a can, wherein the can has a first end defining an aperture configured to surround at least a portion of a perimeter of the first terminal assembly and a terminal stud integrated therein.

Lithium battery system

A lithium battery module includes a plurality of lithium battery cells and a system configured for passing a fluid past at least a portion of the plurality of lithium battery cells in a parallel manner.

Battery with integrally formed terminal

A battery includes a housing and a cover coupled to the housing. The cover includes at least one terminal extending from the cover. The at least one terminal is integrally formed with the cover. The at least one terminal comprises a member having a first portion and a second portion extending from the first portion such that the first portion and the second portion are not colinear. A second aspect relates to the assembly of a cover having an integrally formed terminal and a housing including a seal between cover and housing. A third aspect relates to the interconnection of a plurality of batteries having a cover with integrally formed first and second terminals.

Battery system with improved heat dissipation

A lithium battery system includes a module having a plurality of electrically connected cells, each having a first terminal set and a second terminal set. The lithium battery system also includes a path for heat transfer across the first terminal set of each of the plurality of cells and a path configured to direct a flow of effluent from at least one of the plurality of cells.

Device for laparoscopic tubal ligation

The present disclosure relates to a ligating instrument and end effector assemblies for use in laparoscopic tubal ligation procedures. The ligating instrument includes an integral grasping assembly and an integral end effector actuator and is configured to perform a ligating procedure by operation of a single hand of a user. The ligating instrument includes an integral grasper assembly for grasping a tubular tissue section and removable end effector or suture deployment mechanism for holding open a suture to be positioned about the tubular section. The grasper is configured to draw the tubular section into the open loop of suture material and cinch the suture material about the tubular tissue section. A rotator knob may be provided to orient grasper members associated with the grasper assembly relative to the tissue section. An alternative end effector is provided to removably mount on the distal end of the ligating instrument and to cut that part of the tubular tissue section which needs to be removed after the tubular tissue section has been ligated. A relatively soft over mold section may be provided to at least partially enclose the handle of the ligating instrument in order to provide comfort and facilitate a rsurer grip of the instrument.

Nucleic acid mediated electron transfer

The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.

Electrodes linked via conductive oligomers to nucleic acids

The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.

Medical devices including composites

Medical devices, such as endoprostheses, and methods of making the devices are described. In some embodiments, a medical device includes an elongated hollow body formed of a polymeric matrix containing one or more regions of a pre-determined weight percent of carbon nanotubes in general alignment in a pre-determined orientation. The medical device can have a compressed state with a first transverse dimension and an expanded state with a second relatively greater transverse dimension.

Reinforced medical balloon

The invention relates to medical balloons, and methods of modifying said balloons by forming a void pattern in their exterior surfaces and filling the voids with a material, such as a fiber or a nanomaterial (e.g., nanotubes, such as carbon nanotubes) and a matrix material, e.g., a polymer.

Reinforced medical balloon

The invention relates to medical balloons, and methods of modifying said balloons by forming a void pattern in their exterior surfaces and filling the voids with a material, such as a fiber or a nanomaterial (e.g., nanotubes, such as carbon nanotubes) and a matrix material, e.g., a polymer.

Medical devices including composites

Medical devices, such as endoprostheses, and methods of making the devices are described. In some embodiments, a medical device includes an elongated hollow body formed of a polymeric matrix containing one or more regions of a pre-determined weight percent of carbon nanotubes in general alignment in a pre-determined orientation. The medical device can have a compressed state with a first transverse dimension and an expanded state with a second relatively greater transverse dimension.

Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits

The invention relates to a novel class of magnetic resonance imaging agents that can cross the blood brain barrier and provide accurate magnetic resonance imaging of the brain, especially magnetic resonance images of amyloid deposits associated with Alzheimer's disease.

Vehicular lock apparatus and method

In some embodiments, lock assemblies are disclosed which have a housing (14), a barrel (30), and at least one tumber (23). In some cases, the lock is codeable after the lock assembly has been assembled. Although not required, some embodiments can be re-coded to a new code with and without disassembling the lock assembly. The tumbler(s) (23) can be pivotable, while in other embodiments the tumbler(s) move in a substantially linear fashion. The tumbler(s) can be comprises of two pieces or portions (4, 5, 6, 7), wherein one piece/portion (6, 7) of the tumbler(s) either directly or indirectly engages the coded surface of a key while the other piece/portion (4, 5) is positionable to prevent rotation of the barrel (30) with respect to the housing (14). In some embodiments, the tumblers are external to the barrel.

Medical devices including composites

Medical devices, such as endoprostheses, and methods of making the devices are described. In some embodiments, a medical device includes an elongated hollow body formed of a polymeric matrix containing one or more regions of a pre-determined weight percent of carbon nanotubes in general alignment in a pre-determined orientation. The medical device can have a compressed state with a first transverse dimension and an expanded state with a second relatively greater transverse dimension.

Medical devices and related methods

This disclosure relates to medical devices and related methods. In some embodiments, the methods include applying a material to the balloon and then removing the material from one or more regions of the balloon.

Reinforced and drug-eluting balloon catheters and methods for making same

The present invention generally relates to the field of intravascular medical devices, and more specifically to the field of balloon catheters and other similar diagnostic or therapeutic catheters within the body for treatment and diagnosis of diseases. In particular, the present invention relates to reinforced balloon catheters and drug-eluting balloon catheters and corresponding methods for producing same.

Flight pattern simulator for radar artificial aircraft

Adenoviral vectors able to transduce apcs, potential use in immune response generation

The invention provides a method of inducing an immune response in a mammal. The method comprises administering to the mammal an adenoviral vector comprising (a) a subgroup C fiber protein wherein a native coxsackievirus and adenovirus receptor (CAR)-binding site is disrupted, (b) a subgroup C penton base protein wherein a native integrin-binding site is disrupted, and (c) a nucleic acid sequence encoding at least one antigen derived from an infectious agent other than an adenovirus which is expressed in the mammal to induce an immune response.

4-(pyrrolopyridinyl)pyrimidin-2-ylamine derivatives

Compounds of the formula (I) in which R1, R2, R3, R4 and R5 are each as defined in claim 1 are inhibitors of cell proliferation/cell vitality and can be used for treatment of tumors.

3-(1,2,3-triazol-4-yl) pyrrolo [2,3-b] pyridine derivatives

Compounds of the formula (I), in which R 1 , R 2 and R 3 have the meanings indicated in claim ( 1 ), are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumors.

Steerable guidewire having electrodes for measuring vessel cross-section and blood flow

Abstract of the Disclosure STEERABLE GUIDEWIRE HAVING ELECTRODES FOR MEASURING VESSEL CROSS-SECTION AND BLOOD FLOW A small diameter steerable guidewire that is used to guide a catheter in transluminal coronary angioplasty is provided with a pair of electrodes for measuring the cross-sectional area of a blood vessel and for measuring blood flow. The guidewire includes a shaft and a tip attached to the distal end of the shaft. The shaft is torsionally rigid along its length and includes a conductive tube and a wire extending through the tube. The tip, which can be bent to a prescribed curve when relaxed, is sufficiently flexible to adapt to and follow the contours of a blood vessel. The tip includes a tapered extension of the wire in the shaft. A proximal electrode and a distal electrode are coaxially mounted on the tapered wire and are electrically connected to the tube and the wire, respectively. The electrodes are axially spaced apart by a predetermined distance. Each electrode is preferably a conductive, helically-wound spring. The outside diameter of the steerable guidewire preferably does not exceed about 0.020-inch for coronary use.

Medical devices

Medical devices and related methods are disclosed. In some embodiments, a medical device includes an inflatable balloon (200) having a wall with an interior surface and an exterior surface defining a wall thickness therebetween, and in the exterior surface a void (220) in which the wall thickness is reduced, and a nanomaterial (230) disposed within the void.

CATALYTIC CRACKING WITH BRUSH COOLING.

Un refroidissement brusque efficace est réalisé dans un procédé de craquage catalytique pour udiminuer le craquage thermique. Pour obtenir des rendements en produit augmentés, l'agent de refroidissement brusque est injecté en des emplacements spéciaux et un agent de refroidissement particulier est utilisé. Dans le mode de réalisation illustré, l'agent de refroidissement brusque est injecté dans l'huile constituant le produit immédiatemeent en aval d'un séparateur grossier (106) et l'agent de refroidissement brusque comprend de l'huile de recyclage. Efficient sudden cooling is achieved in a catalytic cracking process to decrease thermal cracking. To achieve increased product yields, the hard coolant is injected at special locations and a special coolant is used. In the illustrated embodiment, the sudden coolant is injected into the product oil immediately downstream of a coarse separator (106) and the sudden coolant comprises recycle oil.

Magnetic resonance imaging agents for the delivery of therapeutic agents

The invention relates to novel magnetic resonance imaging contrast agents th at report on physiological events in a conditional fashion and simultaneously detect the delivery and/or activation of a therapeutically active agent.</SD OAB>

Electronic methods for the detection of analytes

The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.

Medical balloon deflation

Medical balloons are energetically treated to form regions that facilitate deflation to a desirable configuration.

Cutting member for bifurcation catheter assembly

A catheter assembly for deployment in a vessel includes a catheter shaft extending from a proximal end portion to a distal end portion. A balloon is operatively coupled to the distal end portion of the catheter shaft. At least one cutting member is coupled to the catheter assembly. As the balloon is inflated, the cutting member is moved to a position to cut a portion of the vessel.