Mounting system

A mounting system for mounting a blade to a rotor body includes a pitch control mechanism including an anchor and a pitch change rod extending radially outwardly from the anchor to join to a base of the blade. The anchor and the rod are rotatable about the longitudinal axis of the rod to vary the blade pitch. The pitch control mechanism further includes a torque-transmitting formation between the blade and the anchor such that pitch-varying torque can be transmitted to the blade through the torque-transmitting formation while allowing relative radial movement between the blade and the anchor. The system includes a primary bearing formation, which transmits blade centrifugal loads to the rotor body while accommodating variation of the blade pitch, and secondary bearing formation, which transmits pitch change mechanism centrifugal loads to the rotor body while accommodating rotation of the anchor and the rod during variation of the blade pitch.

RADIO FREQUENCY IDENTIFICATION SYSTEM FOR TRACKING AND MANAGING MATERIALS IN A MANUFACTURING PROCESS

A process management system uses a radio frequency identification (RFID) detection system in the form of, for example, a phased array antenna based RFID detection system to track and manage material storage and flow in a manufacturing process or plant. The process management system operates in conjunction with the various machines that implement manufacturing stages or steps of the manufacturing process to assure that the correct materials and processing procedures are used at or on the various production machines of the process to produce a particular product as defined by a job number or job order. The process management system is thereby able to increase the efficiencies of the plant and to increase the quality of the plant production by reducing or eliminating waste, manufacturing errors and shipping errors in the production facility. 1. An inventory tracking system for use in tracking placement of physical items within an inventory tracking region , comprising: a plurality of radio frequency antennas disposed in a spaced apart manner within an inventory tracking region; and', 'a detection controller coupled to the plurality of radio frequency antennas that controls the operation of each of the radio frequency antennas to scan a portion of the inventory tracking region and to detect each of a number of radio frequency tags disposed in the inventory tracking region, wherein the detection controller generates indications of the detected radio frequency tags and the physical locations of the detected radio frequency tags within the inventory tracking region; and, 'a radio frequency tag detection system including;'} a memory for storing inventory item information for each of a plurality of inventory items, the inventory item information for each of the plurality of inventory items including an inventory item radio frequency tag identifier, inventory item identification information defining the identity of the inventory item, and an indication of the current physical ...

RADIO FREQUENCY IDENTIFICATION SYSTEM FOR TRACKING AND MANAGING MATERIALS IN A MANUFACTURING PROCESS

A process management system uses a radio frequency identification (RFID) detection system in the form of, for example, a phased array antenna based RFID detection system to track and manage material storage and flow in a manufacturing process or plant. The process management system operates in conjunction with the various machines that implement manufacturing stages or steps of the manufacturing process to assure that the correct materials and processing procedures are used at or on the various production machines of the process to produce a particular product as defined by a job number or job order. The process management system is thereby able to increase the efficiencies of the plant and to increase the quality of the plant production by reducing or eliminating waste, manufacturing errors and shipping errors in the production facility. 1. (canceled)2. An inventory tracking system , comprising:one or more radio frequency antennas disposed within an inventory tracking region and configured to use a beam to scan a portion of the inventory tracking region to detect a current physical location of one or more radio frequency tags within a scanned portion of the inventory tracking region; and control an operation of the one or more radio frequency antennas and to calculate the current physical location of the one or more radio frequency tags as a region defined by a range of two respective coordinate units in a multi-dimensional coordinate system, the range of the two respective coordinate units being calculated based upon radio frequency signals emitted by the one or more radio frequency tags and received via the one of the one or more radio frequency antennas;', 'generate indications of and the current physical locations of the one or more detected radio frequency tags within the scanned portion of the inventory tracking region;', 'store inventory item information for one or more inventory items, the inventory item information including (i) an inventory item radio ...

RADIO FREQUENCY IDENTIFICATION SYSTEM FOR TRACKING AND MANAGING MATERIALS IN A MANUFACTURING PROCESS

A process management system uses a radio frequency identification (RFID) detection system in the form of, for example, a phased array antenna based RFID detection system to track and manage material storage and flow in a manufacturing process or plant. The process management system operates in conjunction with the various machines that implement manufacturing stages or steps of the manufacturing process to assure that the correct materials and processing procedures are used at or on the various production machines of the process to produce a particular product as defined by a job number or job order. The process management system is thereby able to increase the efficiencies of the plant and to increase the quality of the plant production by reducing or eliminating waste, manufacturing errors and shipping errors in the production facility. 1. A method of controlling a manufacturing process associated with a manufacturing job order , comprising:identifying, by a command system, a job order recipe associated with the manufacturing job order,wherein the job order recipe identifies one or more material inputs to a manufacturing stage that implements a production machine to produce a manufactured product in accordance with the manufacturing job order,searching, by the command system, a database to identify one or more radio frequency identification (RFID) tags that are physically associated with each of the one or more material inputs;determining, by the command system, a position of the one or more RFID tags; andcontrolling, by a process controller in communication with the command system, operation of the production machine implemented by the manufacturing stage based upon whether the position of the one or more RFID tags matches a location of the manufacturing stage as indicated by the manufacturing job order.2. The method of claim 1 , wherein the act of searching the database to identify the one or more RFID tags comprises:searching the database to identify one or ...

RADIO FREQUENCY IDENTIFICATION SYSTEM FOR TRACKING AND MANAGING MATERIALS IN A MANUFACTURING PROCESS

A process management system uses a radio frequency identification (RFID) detection system in the form of, for example, a phased array antenna based RFID detection system to track and manage material storage and flow in a manufacturing process or plant. The process management system operates in conjunction with the various machines that implement manufacturing stages or steps of the manufacturing process to assure that the correct materials and processing procedures are used at or on the various production machines of the process to produce a particular product as defined by a job number or job order. The process management system is thereby able to increase the efficiencies of the plant and to increase the quality of the plant production by reducing or eliminating waste, manufacturing errors and shipping errors in the production facility. 1. A method of controlling a manufacturing process , comprising:receiving, by one or more processors, a manufacturing job order having a job order recipe, the job order recipe identifying (i) a plurality of manufacturing stages, and (ii) one or more manufacturing inputs to each of the plurality of manufacturing stages used to produce a finished product in accordance with the manufacturing process;determining, by one or more processors, the one or more manufacturing inputs to each of the plurality of manufacturing stages as specified by the job order recipe;identifying, by one or more processors, one or more radio frequency identification (RFID) tags associated with each of the one or more manufacturing inputs;determining, by one or more processors, a position of the one or more RFID tags with respect to each of the one or more manufacturing inputs; andverifying, by one or more processors, that the one or more manufacturing inputs are located at each of the one or more manufacturing stages as indicated by the job order recipe based upon the position of the one or more RFID tags.2. The method of claim 1 , further comprising:reading, ...

RADIO FREQUENCY IDENTIFICATION SYSTEM FOR TRACKING AND MANAGING MATERIALS IN A MANUFACTURING PROCESS

A process management system uses a radio frequency identification (RFID) detection system in the form of, for example, a phased array antenna based RFID detection system to track and manage material storage and flow in a manufacturing process or plant. The process management system operates in conjunction with the various machines that implement manufacturing stages or steps of the manufacturing process to assure that the correct materials and processing procedures are used at or on the various production machines of the process to produce a particular product as defined by a job number or job order. The process management system is thereby able to increase the efficiencies of the plant and to increase the quality of the plant production by reducing or eliminating waste, manufacturing errors and shipping errors in the production facility. 1. A method of controlling a manufacturing process , comprising:scanning a region in which a manufacturing process occurs to resolve a location of a radio frequency identification (RFID) tag within the region based on a signal transmitted by the RFID tag;determining whether a manufacturing item corresponding to an identity of the RFID tag used in the manufacturing process is at a location in accordance with a manufacturing job order; andaffecting operation of the manufacturing process based on whether the manufacturing item is at a location in accordance with the manufacturing job order.2. The method of claim 1 , wherein the act of scanning comprises:scanning the region to resolve the location of the RFID tag based on a direction of a beam used to scan the RFID tag and an amount of time needed to receive the signal transmitted by the RFID tag.3. The method of claim 1 , wherein the act of scanning comprises:scanning the region with a plurality of antennas to resolve the location of the RFID tag based on a triangulation of the signal transmitted by the RFID tag between the plurality of antennas.4. The method of claim 1 , wherein the ...

RFID-BASED INVENTORY TRACKING SYSTEM

An asset management and tracking system for use in a facility having a product designation RFID tag having product information is attached to a product and at least one location designation RFID tag having location information. The system includes a RFID reader and a portable communication device. The RFID reader reads at least one of the product designation RFID tag and the at least one location designation RFID tag and the portable communication device receives product information from and transmits product information to an asset tracking and management device. The RFID reader transmits product information read from the product designation RFID tag and the location information read from the location designation RFID tags to the portable communication device. The portable communication device, in turn, transmits the received product information and location information to the asset tracking device and queries the asset tracking device for additional product and location information. 1. An asset management and tracking system for use in a facility having a product designation radio frequency identification (RFID) tag attached to a product disposed within the facility , the product designation RFID tag indicating product information , and the facility further having at least one location designation radio frequency identification (RFID) tag , each of the at least one location designation RFID tag indicating respective location information , the system comprising:a radio frequency identification (RFID) reader configured to read a product designation RFID tag, the RFID reader being mounted to a movable device; anda portable communication device configured to communicate with an asset tracking and management device to communicate product information, the portable communication device being communicatively coupled to the RFID reader; anda proximity sensor on the movable device and configured to control the RFID reader to read a product designation RFID tag on an object ...

Method of manufacturing a metal matrix reinforced composite component and a composite component formed by the method

Method of manufacturing a metal matrix composite component includes the steps of providing a first tubular member having a first end and an opposite second end, the first tubular member's first end being formed as a first end block; positioning a metal matrix composite tubular member concentrically the first tubular member; positioning a second tubular member concentrically over metal matrix composite tubular member, second tubular member having a first end and an opposite second end, the second tubular member's second end being formed as a second end block; welding first tubular member's first end to the second tubular member's first end, and the first tubular member's second end to second tubular member's second end, to join the first and second tubular member and thereby to form a metal matrix composite preform; and consolidating metal matrix composite preform by a hot isostatic pressing process to form the metal matrix composite component.

COLLAPSIBLE SHIPPING CONTAINER

A collapsible and stackable shipping container for shipping a product may be reused and customized for the product to be shipped. The shipping container includes a base, a plurality of support struts mounted on the base, and a top or a cover. The plurality of support struts are movable relative to the base between an upright position and a collapsed position. Each support strut may be rotatably attached to the base and may fit within feet or other support structures formed within the base. In the collapsed position, the plurality of support struts are stored on the base, such as within one or more cavities formed in the base. The shipping container may include a radio-frequency identification (RFID) tag for use in tracking the shipping container or a system of shipping containers. 1. A pallet for shipping a product , the pallet comprising:a base;a plurality of support struts, each one of the support struts being movable relative to the base between an upright position and a collapsed position;a multiplicity of connectors mounted to the base, each one of the connectors being adapted to receive a different one of the support struts to secure the different one of the support struts to the base.2. The pallet of claim 1 , further comprising a radio-frequency identification (RFID) tag attached to the base.3. The pallet of claim 1 , further comprising an insert removably attachable to the base claim 1 , the insert including a stability element of a predetermined shape to receive a product.4. The pallet of claim 1 , further comprising a stability element formed in the base claim 1 , wherein the stability element includes a predetermined shape that is sized to receive a product.5. The pallet of claim 1 , further comprising an insert removably attachable to the base claim 1 , the insert including a moldable material adapted to form to a shape of a product.6. The pallet of claim 1 , further comprising an insert removably disposed above the base and in between the plurality of ...

RFID-BASED INVENTORY TRACKING SYSTEM

An asset management and tracking system for use in a facility having a product designation RFID tag having product information is attached to a product and at least one location designation RFID tag having location information. The system includes a RFID reader and a portable communication device. The RFID reader reads at least one of the product designation RFID tag and the at least one location designation RFID tag and the portable communication device receives product information from and transmits product information to an asset tracking and management device. The RFID reader transmits product information read from the product designation RFID tag and the location information read from the location designation RFID tags to the portable communication device. The portable communication device, in turn, transmits the received product information and location information to the asset tracking device and queries the asset tracking device for additional product and location information. 1. An asset management and tracking system for use in a facility having a product designation radio frequency identification (RFID) tag attached to a product disposed within the facility , the product designation RFID tag including product information , the system comprising: an inlay having an antenna, an integrated circuit, and a substrate, the antenna and the integrated circuit being disposed on the substrate;', 'a first layer disposed on a first side of the inlay, the first layer having a first thickness; and', 'a second layer disposed on a second side of the inlay, the second layer having a second thickness;, 'at least one location designation radio frequency identification (RFID) tag disposed within the facility and including location information, the location designation RFID tag comprisinga radio frequency identification (RFID) reader configured to read at least one of the product designation RFID tag and the at least one location designation RFID tag, the RFID reader being ...

Microbiome health index

Methods for assessing microbiota are disclosed. An example method for assessing microbiota may include obtaining a fecal sample from a patient, quantifying the relative abundance of bacteria from a selected group of taxonomic classes in the fecal sample, calculating a microbiome health index based on the relative abundance of bacteria from the selected group of taxonomic classes, and correlating the microbiome health index with a medical condition of the patient.

RFID-Based Inventory Tracking System

An asset management and tracking system for use in a facility having a product designation RFID tag having product information is attached to a product and at least one location designation RFID tag having location information. The system includes a RFID reader and a portable communication device. The RFID reader reads at least one of the product designation RFID tag and the at least one location designation RFID tag and the portable communication device receives product information from and transmits product information to an asset tracking and management device. The RFID reader transmits product information read from the product designation RFID tag and the location information read from the location designation RFID tags to the portable communication device. The portable communication device, in turn, transmits the received product information and location information to the asset tracking device and queries the asset tracking device for additional product and location information. 1. An asset management and tracking system for use in a facility having a product designation radio frequency identification (RFID) tag attached to a product disposed within the facility and at least one location designation radio frequency identification (RFID) tag disposed within the facility , the product designation RFID tag including product information and the location designation RFID tag including location information , the system comprising:a radio frequency identification (RFID) reader configured to read at least one of the product designation RFID tag and the at least one location designation RFID tag, the RFID reader being mounted to a movable device; anda portable communication device configured to receive product information from and transmit product information to an asset tracking and management device, the portable communication device being communicatively coupled to the RFID reader and mounted on a movable device;wherein, the RFID reader is configured to transmit the ...

EASILY ATTACHABLE RFID TAG AND METHOD OF MAKING THE SAME

A location designation RFID tag for use in a storage facility includes an inlay, a first layer disposed on a first side of the inlay and having a first thickness, and a second layer disposed on a second side of the inlay. The first layer has a first thickness and the second layer has a second thickness. The inlay includes substrate, an antenna disposed on the substrate, and an integrated circuit disposed on the substrate. The location designation RFID tag may be easily and non-invasively placed and relocated on a floor of a storage facility in a manner that mitigates, and likely resolves, the issues experienced by known RFID tags when placed on a floor. Utilizing an inlay having a long, thin antenna, reduces the overall thickness of the location designation RFID tag, which allows layers to be disposed on the inlay that include a sufficient thickness to improve durability, mitigate detuning, and allow movable devices to readily pass over the location designation RFID tag. 1. A location designation radio frequency identification (RFID) tag for use in a facility , the RFID tag comprising: an antenna,', 'an integrated circuit, and', 'a substrate, the antenna and the integrated circuit being disposed on the substrate;, 'an inlay, comprising 'a second layer disposed on a second side of the inlay, the second layer having a second thickness.', 'a first layer disposed on a first side of the inlay, the first layer having a first thickness; and'}2. The location designation RFID tag of claim 1 , further comprising a printing layer fixedly disposed on the first layer such that the printing layer accepts printing.3. The location designation RFID tag of claim 1 , wherein the second layer has a first side and a second side claim 1 , the first side being disposed near the inlay and the second side being disposed opposite the inlay claim 1 , andwherein the second side of the second layer includes an adhesive disposed thereon.4. The location designation RFID tag of claim 1 , wherein ...

Methods and compositions for determining treatment regimens in systemic inflammatory response syndromes

The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to rule in or out SIRS, or for differentiating sepsis, severe sepsis, septic shock and/or MODS from each other and/or from non-infectious SIRS.

Methods for monitoring the status of assays and immunoassays

The invention relates in part to the use of independent assay controls (IACs) for the optical communication between an assay device and an instrument in monitoring and performing assays, preferably immunoassays.

Diagnostic devices for the controlled movement of reagents without membranes

The assay devices, assay systems and device components of this invention comprise at least two opposing surfaces disposed a capillary distance apart, at least one of which is capable of immobilizing at least one target ligand or a conjugate in an amount related to the presence or amount of target ligand in the sample from a fluid sample in a zone for controlled fluid movement to, through or away the zone. The inventive device components may be incorporated into conventional assay devices with membranes or may be used in the inventive membrane-less devices herein described and claimed. These components include flow control elements, measurement elements, time gates, elements for the elimination of pipetting steps, and generally, elements for the controlled flow, timing, delivery, incubation, separation, washing and other steps of the assay process.

Methods for the assay of troponin I and T and selection of antibodies for use in immunoassays

Assays and antibodies are disclosed for the detection and quantitation of cardiac specific troponin I and troponin T in body fluids as an indicator of myocardial infarction. Since troponin I and T exist in various conformations in the blood, the ratios of the monomeric troponin I and T and the binary and ternary complexes may be related to the metabolic state of the heart. More specifically, immunoassays for determining the presence or amount of free, binary and ternary complexes of troponin I and T are claimed.

Diagnostic devices and apparatus for the controlled movement of reagents without membrances

The assay devices, assay systems and device components of this invention comprise at least two opposing surfaces disposed a capillary distance apart, at least one of which is capable of immobilizing at least one target ligand or a conjugate in an amount related to the presence or amount of target ligand in the sample from a fluid sample in a zone for controlled fluid movement to, through or away the zone. The inventive device components may be incorporated into conventional assay devices with membranes or may be used in the inventive membrane-less devices herein described and claimed. These components include, flow control elements, measurement elements, time gates, elements for the elimination of pipetting steps, and generally, elements for the controlled flow, timing, delivery, incubation, separation, washing and other steps of the assay process.

Lysis chamber for use in an assay device

A lysis chamber of an assay device capable of producing lysis of cells in a sample fluid such as whole blood, said chamber comprising a surface which contacts the sample fluid when the sample fluid is placed into the assay device; and a lytic material immobilized on the surface, whereby cells of the sample fluid are lysed when they contact the lytic material. The chamber can delimit a capillary space, and lytic material can be saponin or a detergent. Methods employing devices comprising such chambers can assay for whole blood amounts of cyclosporin or hemoglobin A1c.

Non-porous diagnostic devices for the controlled movement of reagents

The assay devices, assay systems and device components of this invention comprise at least two opposing surfaces disposed a capillary distance apart, at least one of which is capable of immobilizing at least one target ligand or a conjugate in an amount related to the presence or amount of target ligand in the sample from a fluid sample in a zone for controlled fluid movement to, through or away the zone. The inventive device components may be incorporated into conventional assay devices with membranes or may be used in the inventive membrane-less devices herein described and claimed. These components include, flow control elements, measurement elements, time gates, elements for the elimination of pipetting steps, and generally, elements for the controlled flow, timing, delivery, incubation, separation, washing and other steps of the assay process.

Diagnostic devices and apparatus for the controlled movement of reagents without membranes

The assay devices, assay systems and device components of this invention comprise at least two opposing surfaces disposed a capillary distance apart, at least one of which is capable of immobilizing at least one target ligand or a conjugate in an amount related to the presence or amount of target ligand in the sample from a fluid sample in a zone for controlled fluid movement to, through or away the zone. The inventive device components may be incorporated into conventional assay devices with membranes or may be used in the inventive membrane-less devices herein described and claimed. These components include flow control elements, measurement elements, time gates, elements for the elimination of pipetting steps, and generally, elements for the controlled flow, timing, delivery, incubation, separation, washing and other steps of the assay process.

Diagnostic markers of acute coronary syndromes and methods of use thereof

The present invention relates to methods for the diagnosis and evaluation of acute coronary syndromes. In particular, patient test samples are analyzed for the presence and amount of members of a panel of markers comprising one or more specific markers for myocardial injury and one or more non-specific markers for myocardial injury. A variety of markers are disclosed for assembling a panel of markers for such diagnosis and evaluation. In various aspects, the invention provides methods for the early detection and differentiation of stable angina, unstable angina, and myocardial infarction. Invention methods provide rapid, sensitive and specific assays that can greatly increase the number of patients that can receive beneficial treatment and therapy, reduce the costs associated with incorrect diagnosis, and provide important information about the prognosis of the patient.

Diagnostic devices and apparatus for the controlled movement of reagents without membranes

The assay devices, assay systems and device components of this invention comprise at least two opposing surfaces disposed a capillary distance apart, at least one of which is capable of immobilizing at least one target ligand or a conjugate in an amount related to the presence or amount of target ligand in the sample from a fluid sample in a zone for controlled fluid movement to, through or away the zone. The inventive device components may be incorporated into conventional assay devices with membranes or may be used in the inventive membrane-less devices herein described and claimed. These components include, flow control elements, measurement elements, time gates, elements for the elimination of pipetting steps, and generally, elements for the controlled flow, timing, delivery, incubation, separation, washing and other steps of the assay process.

Methods for improving the recovery of troponin I and T in membranes, filters and vessels

A method to facilitate recovery troponin I and/or troponin T from a sample comprising addition of troponin C to the sample or to a surface from which the troponin I and/or troponin T are recovered.

Diagnostic devices and apparatus for the controlled movement of reagents without membranes

The assay devices, assay systems and device components of this invention comprise at least two opposing surfaces disposed a capillary distance apart, at least one of which is capable of immobilizing at least one target ligand or a conjugate in an amount related to the presence or amount of target ligand in the sample from a fluid sample in a zone for controlled fluid movement to, through or away the zone. The inventive device components may be incorporated into conventional assay devices with membranes or may be used in the inventive membrane-less devices herein described and claimed. These components include flow control elements, measurement elements, time gates, elements for the elimination of pipetting steps, and generally, elements for the controlled flow, timing, delivery, incubation, separation, washing and other steps of the assay process.

Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network

Devices for use in heterogeneous ligand-receptor assays, having a porous member in contact with a nonabsorbent textured surface, where the surface texturing is such that a capillary network is formed when in fluid communication with the porous member. More particularly, these devices comprise: (a) a porous member having (i) at least one binding agent capable of immobilizing at least one target ligand on the porous member from a fluid sample in at least one zone and (ii) a means for detecting the presence or amount of said target ligand as a result of the assay process; and (b) a nonabsorbent member in fluid communication with the porous member, the nonabsorbent member forming at least one capillary with the porous member so that when sample, alone or in combination with other fluids, is added to the porous member, fluid is drawn through the porous member.

Flavin derivatives

The present invention relates novel flavin derivatives and other flavin derivatives, their use and compositions for use as riboswitch ligands and/or anti-infectives. The invention also provides method of making novel flavin derivatives.

Flavin derivatives

The present invention relates novel flavin derivatives and other flavin derivatives, their use and compositions for use as riboswitch ligands and/or anti-infectives. The invention also provides method of making novel flavin derivatives.

Diagnostic devices for the controlled movement of reagents without membranes

The assay devices, assay systems and device components of this invention comprise at least two opposing surfaces disposed a capillary distance apart, at least one of which is capable of immobilizing at least one target ligand or a conjugate in an amount related to the presence or amount of target ligand in the sample from a fluid sample in a zone for controlled fluid movement to, through or away the zone. The inventive device components may be incorporated into conventional assay devices with membranes or may be used in the inventive membrane-less devices herein described and claimed. These components include flow control elements, measurement elements, time gates, elements for the elimination of pipetting steps, and generally, elements for the controlled flow, timing, delivery, incubation, separation, washing and other steps of the assay process.

Diagnostic devices and apparatus for the controlled movement of reagents without membranes

The assay devices, assay systems and device components of this invention comprise at least two opposing surfaces disposed a capillary distance apart, at least one of which is capable of immobilizing at least one target ligand or a conjugate in an amount related to the presence or amount of target ligand in the sample from a fluid sample in a zone for controlled fluid movement to, through or away the zone. The inventive device components may be incorporated into conventional assay devices with membranes or may be used in the inventive membrane-less devices herein described and claimed. These components include flow control elements, measurement elements, time gates, elements for the elimination of pipetting steps, and generally, elements for the controlled flow, timing, delivery, incubation, separation, washing and other steps of the assay process.

Diagnostic devices and apparatus for the controlled movement of reagents without membranes

The assay devices, assay systems and device components of this invention comprise at least two opposing surfaces disposed a capillary distance apart, at least one of which is capable of immobilizing at least one target ligand or a conjugate in an amount related to the presence or amount of target ligand in the sample from a fluid sample in a zone for controlled fluid movement to, through or away the zone. The inventive device components may be incorporated into conventional assay devices with membranes or may be used in the inventive membrane-less devices herein described and claimed. These components include flow control elements, measurement elements, time gates, elements for the elimination of pipetting steps, and generally, elements for the controlled flow, timing, delivery, incubation, separation, washing and other steps of the assay process.

Dual liquid dispenser package

Dual liquid dispenser package is provided and is operable to supply liquids from liquid supply chambers to liquid reservoirs through liquid supply channels by centrifugal force-induced liquid displacement and flow attendant dispenser package rotation. The supply channels include means to greatly inhibit, if not totally prevent, liquid foaming attendant liquid flow from the supply chambers to the reservoirs. Vents are included to vent the liquid supply chambers to atmosphere to prevent vacuum build-up therein, and include means preventing spillage of the liquids from the dispenser package through the vents. The dispenser package is particularly adapted for use in the supply of two reagent liquids to automated sample liquid analysis systems.

Compositions and methods for inhibiting light-induced inactivation of biological reagents

Disclosed is a fluorescent conjugate comprising a biological reagent, a fluorescent molecule, and a means for impeding phototoxic degradation of the biological reagent. The impeding means can be a cross-linking substance having a long molecular distance, whereby the cross-linking substance links the fluorescent molecule and the biological reagent; a quencher of singlet oxygen; a quencher of a free radical; or a combination thereof. Also disclosed is a solution comprising a fluorescent conjugate of a biological reagent and a fluorescent molecule together with an oxygen depleting system.

Methods and compositions related to the modulation of riboswitches

Disclosed herein are methods and compositions related to the detection of conformational changes and interactions with trigger molecules in riboswitches.

Treadmill control system

A microprocessor based exercise treadmill control system is disclosed which includes various features to enhance user operation. These features include programs operative to: permit a set of user controls to cause the treadmill to initially operate at predetermined speeds; permit the user to design custom workouts; permit the user to switch between workout programs while the treadmill is in operation; and perform an automatic cooldown program where the duration of the cooldown is a function of the duration of the workout or the user's heart rate. The features also include a stop program responsive to a detector for automatically stopping the treadmill when a user is no longer on the treadmill and a frame tag module attached to the treadmill frame having a non-volatile memory for storing treadmill configuration, and operational and maintenance data. Another included feature is the ability to display the amount of time a user spends in a heart rate zone.

Therapeutic peptides

Therapeutic peptides

The present disclosure provides, in part, compositions comprising peptides immunospecifically binds to MHC class I polypeptide-related sequence A (MICA).

Polypeptides related to natriuretic peptides and methods of their identification and use

The present invention relates to the identification and use of polypeptides that bind to antibodies directed to a desired polypeptide of interest. Using natriuretic peptides and their precursors, and in particular BNP, as an example, the present invention describes a number of natriuretic peptides fragments produced in biological samples, most preferably blood-derived samples, that bind to antibodies directed to BNP. Because production of such fragments is an ongoing process that may be a function of, inter alia, the elapsed time between onset of an event triggering natriuretic peptide release into the tissues and the time the sample is obtained or analyzed; the elapsed time between sample acquisition and the time the sample is analyzed; the type of tissue sample at issue; the storage conditions; the quantity of proteolytic enzymes present; etc., such fragments may be used when both designing an assay for one or more natriuretic peptides, and when performing such an assay, in order to provide an accurate prognostic or diagnostic result.

Diagnostic markers of acute coronary syndrome and methods of use thereof

The present invention relates to methods for the diagnosis and evaluation of acute coronary syndromes. In particular, patient test samples are analyzed for the presence and amount of members of a panel of markers comprising one or more specific markers for myocardial injury and one or more non-specific markers for myocardial injury. A variety of markers are disclosed for assembling a panel of markers for such diagnosis and evaluation. In various aspects, the invention provides methods for the early detection and differentiation of stable angina, unstable angina, and myocardial infarction. Invention methods provide rapid, sensitive and specific assays that can greatly increase the number of patients that can receive beneficial treatment and therapy, reduce the costs associated with incorrect diagnosis, and provide important information about the prognosis of the patient.

Diagnostic markers of stroke and cerebral injury and methods of use thereof

The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. In a particular aspect, patient samples are analyzed for the presence or amount of a panel of markers comprising one or more specific markers for cerebral injury and one or more non-specific markers for cerebral injury. In an alternative aspect, samples are analyzed for B-type natriuretic peptide. A variety of markers are disclosed for assembling a panel for such diagnosis and evaluation. In various aspects, the invention provides methods for early detection and differentiation of stroke types and transient ischemic attacks, for determining the prognosis of a patient presenting with stroke symptoms, and identifying a patient at risk for cerebral vasospasm. Invention methods provide rapid, sensitive and specific assays to greatly increase the number of patients that can receive beneficial stroke treatment and therapy, and reduce the costs associated with incorrect stroke diagnosis.

Diagnostic markers of stroke and cerebral injury and methods of use thereof

The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. A variety of markers are disclosed for assembling a panel for such diagnosis and evaluation. In various aspects, the invention provides methods for early detection and differentiation of stroke types and transient ischemic attacks, for determining the prognosis of a patient presenting with stroke symptoms, and identifying a patient at risk for cerebral vasospasm. Invention methods provide rapid, sensitive and specific assays to greatly increase the number of patients that can receive beneficial stroke treatment and therapy, and reduce the costs associated with incorrect stroke diagnosis.

Polypeptides related to natriuretic peptides and methods of their identification and use

The present invention relates to the identification and use of polypeptides that bind to antibodies directed to a desired polypeptide of interest. Using natriuretic peptides and their precursors, and in particular BNP, as an example, the present invention describes a number of natriuretic peptides fragments produced in biological samples, most preferably blood-derived samples, that bind to antibodies directed to BNP. Because production of such fragments is an ongoing process that may be a function of, inter alia, the elapsed time between onset of an event triggering natriuretic peptide release into the tissues and the time the sample is obtained or analyzed; the elapsed time between sample acquisition and the time the sample is analyzed; the type of tissue sample at issue; the storage conditions; the quantity of proteolytic enzymes present; etc., such fragments may be used when both designing an assay for one or more natriuretic peptides, and when performing such an assay, in order to provide an accurate prognostic or diagnostic result.

Methods and compositions for determining treatment regimens in systemic inflammatory response syndromes

The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to rule in or out SIRS, or for differentiating sepsis, severe sepsis, septic shock and/or MODS from each other and/or from non-infectious SIRS.

Methods and compositions for determining treatment regimens in systemic inflammatory response syndromes

The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to rule in or out SIRS, or for differentiating sepsis, severe sepsis, septic shock and/or MODS from each other and/or from non-infectious SIRS.

Methods and compositions for the diagnosis of sepsis

The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to rule in or out SIRS, or for differentiating sepsis, severe sepsis, and/or septic shock from each other and/or from non-infectious SIRS.

Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes

Use of natriuretic peptides as diagnostic and prognostic indicators in vascular diseases

The present invention relates to methods for the diagnosis and evaluation of subclinical atherosclerosis. In particular, patient test samples are analyzed for the presence and amount of one or more natriuretic peptides. A variety of additional markers are disclosed for assembling a panel of markers for such diagnosis and evaluation.

Markers for differential diagnosis and methods of use thereof

The present invention provides methods for the identification and use of diagnostic markers for differential diagnosis of diseases. In a various aspects, the invention relates to methods and compositions able to determine the presence or absence of one, and preferably a plurality, of diseases that exhibit one or more similar or identical symptoms. Such methods and compositions can be used to provide assays and assay devices for use in determining the disease underlying one or more non-specific symptoms exhibited in a clinical setting.

Markers for differential diagnosis and methods of use thereof

Diagnostic markers of acute coronary syndromes and methods of use thereof

Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes

Provided are methods and compositions for symptom-based differential diagnosis, prognosis and determination of treatment regimens in subjects In particular, the methods and compositions provided are selected to rule in or out SIRS, or for differentiating sepsis, severe sepsis, septic shock and/or MODS from each other and/or from non-infectious SIRS.

Methods and compositions for the diagnosis of venous thromboembolic disease

The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to rule in or out venous thromboembolic disease, pulmonary embolism, and/or deep vein thrombosis, and for risk stratification in such conditions.

Diagnostic markers of stroke and cerebral injury and methods of use thereof

The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. In a particular aspect, patient samples are analyzed for the presence or amount of a panel of markers comprising one or more specific markers for cerebral injury and one or more non-specific markers for cerebral injury. In an alternative aspect, samples are analyzed for B-type natriuretic peptide. A variety of markers are disclosed for assembling a panel for such diagnosis and evaluation. In various aspects, the invention provides methods for early detection and differentiation of stroke types and transient ischemic attacks, for determining the prognosis of a patient presenting with stroke symptoms, and identifying a patient at risk for cerebral vasospasm. Invention methods provide rapid, sensitive and specific assays to greatly increase the number of patients that can receive beneficial stroke treatment and therapy, and reduce the costs associated with incorrect stroke diagnosis.

Diagnostic markers of stroke and cerebral injury and methods of use thereof

The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. A variety of markers are disclosed for assembling a panel for such diagnosis and evaluation. In various aspects, the invention provides methods for early detection and differentiation of stroke types and transient ischemic attacks, for determining the prognosis of a patient presenting with stroke symptoms, and identifying a patient at risk for cerebral vasospasm. Invention methods provide rapid, sensitive and specific assays to greatly increase the number of patients that can receive beneficial stroke treatment and therapy, and reduce the costs associated with incorrect stroke diagnosis.

Therapeutic peptides

The present disclosure provides, in part, compositions comprising peptides immuno specifically binds to defined binding partners, wherein the peptides comprise at least complementarity determining regions relating to the complementarity regions shown in Table 1.

Therapeutic peptides

The present disclosure provides, in part, compositions comprising peptides immunospecifically binds to MHC class I polypeptide-related sequence A (MICA).

Therapeutic peptides

The present disclosure provides, in part, compositions comprising peptides that immunospecifically bind to a defined binding partner, such as MHC class I polypeptide-related sequence A (MICA), or an epitope thereon. In some embodiments, the peptides comprise one or more complementarity determining regions relating to the complementarity regions shown in Table 1. The disclosure also provides methods of treating cancer in a subject using the compositions disclosed herein, and methods of isolating human antibodies from cancer patients following immunotherapy.

Therapeutic peptides

The present disclosure provides, in part, compositions comprising peptides immuno specifically binds to defined binding partners, wherein the peptides comprise at least complementarity determining regions relating to the complementarity regions shown in Table 1.

Therapeutic peptides

The present disclosure provides, in part, compositions comprising peptides immunospecifically binds to defined binding partners, wherein the peptides comprise at least complementarity determining regions relating to the complementarity regions shown in Table 1.

Antibodies that bind to MHC class I polypeptide-related sequence A

The present disclosure provides, in part, compositions comprising peptides immunospecifically binds to MHC class I polypeptide-related sequence A (MICA).

GLP-1 formulations with protracted time action

The present invention encompasses compositions wherein a GLP-1 compound is complexed with a basic polypeptide. The compositions provide a prolonged duration of action and can be administered by the pulmonary route.

Novel squalene synthetase inhibitors

This invention relates to compounds of structural formula (I): which are squalene synthetase inhibitors and thus useful as cholesterol lowering agents.

Ester derivatives of dioxabicyclo(3,2,1)-octane, medicaments, and a fungus which makes them

Process for detecting LDHk isozyme activity in human serum for use as a diagnostic aid and for monitoring response to cancer therapy

An improved assay procedure for quantitatively detecting LDH k isozyme in human serum is provided which utilizes previously known electrophoretic gel separation procedures combined with an improved staining method wherein the staining solution has a constant temperature of about 37° C. and a pH of about 8.0, and is contacted with the gel matrix for at least 3 hours in the absence of oxygen and light. This improved assay procedure may be used as an adjunct to other procedures for diagnosing the presence of primary cancer, as a post-operative indicator of metastatic cancer and in monitoring the success of cancer therapy.

Process for detecting LDHk isozyme activity in human serum for use as a diagnostic aid and for monitoring response to cancer therapy

An improved assay procedure for quantitatively detecting LDH k isozyme in human serum is provided which utilizes previously known electrophoretic gel separation procedures combined with an improved staining method wherein the staining solution has a constant temperature of about 37° C. and a pH of about 8.0, and is contacted with the gel matrix for at least 3 hours in the absence of oxygen and light. This improved assay procedure may be used as an adjunct to other procedures for diagnosing the presence of primary cancer, as a post-operative indicator of metastatic cancer and in monitoring the success of cancer therapy.

Exercise treadmill

To improve tracking, an exercise treadmill is provided with a frame including molded plastic pulleys, having an integral gear belt sprocket, an endless belt extending around the pulleys and a motor operatively connected to the rear pulley to drive the belt. The pulleys are molded out of plastic and have a diameter of approximately nine inches. A mold and method for producing large diameter treadmill pulleys having an integrally molded sprocket are also disclosed. A deck underneath the running surface of the belt is supported by resilient members. A positive lateral belt tracking mechanism is used to correct the lateral position of the belt. A belt position sensor mechanism is used in combination with a front pulley pivoting mechanism to maintain the belt in the desired lateral position on the pulleys. The exercise treadmill also includes a lift mechanism with an internally threaded sleeve engaged to vertically aligned nonrotating screws. A user display of foot impact force on the belt is also provided.

Methods and compositions for measuring natriuretic peptides and uses thereof

The present invention describes compositions and methods designed to determine the presence or amount of natriuretic peptides, or their fragments, in a sample. The degradation of natriuretic peptides is an ongoing process that may be a function of, inter alia, the elapsed time between onset of an event triggering natriuretic peptide release into the tissues and the time the sample is obtained or analyzed; the quantity of proteolytic enzymes present; etc. This degradation can produce circulating amounts of natriuretic peptides having reduced or lost biological function. The present invention provides, inter alia, assays designed to accurately measure biologically active natriuretic peptides, and compositions to inhibit a previously unknown pathway for degradation of natriuretic peptides.

Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes

The present invention relates to materials and procedures for evaluating the prognosis of patients suffering from acute coronary syndromes. In particular, the level of BNP, or a marker related to BNP, in a patient sample, alone or in combination with one or more other prognostic markers, provides prognostic information useful for predicting near-term morbidity and/or mortality across the entire spectrum of acute coronary syndromes, including unstable angina, non-ST-elevation non-Q wave myocardial infarction, ST-elevation non-Q wave MI, and transmural (Q-wave) MI.

Diagnostic markers of stroke and cerebral injury and methods of use thereof

The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. In a particular aspect, patient sampl es are analyzed for the presence or amount of a panel of markers comprising one or more specific markers for cerebral injury and one or more non-specific markers for cerebral injury. In an alternative aspect, samples are analyzed for B-type natriuretic peptide. A variety of markers are disclosed for assembling a panel for such diagnosis and evaluation. In various aspects, th e invention provides methods for early detection and differentiation of stroke types and transient ischemic attacks, for determining the prognosis of a patient presenting with stroke symptoms, and identifying a patient at risk f or cerebral vasospasm. Invention methods provide rapid, sensitive and specific assays to greatly increase the number of patients that can receive beneficia l stroke treatment and therapy, and reduce the costs associated with incorrect stroke diagnosis.

Methods and compositions for measuring biologically active natriuretic peptides and for improving their therapeutic potential

The present invention describes compositions and methods designed to determine the presence or amount of biologically active natriuretic peptides, or their fragments, in a sample. The degradation of natriuretic peptides is an ongoing process that may be a function of, inter alia, the elapsed time between onset of an event triggering natriuretic peptide release into the tissues and the time the sample is obtained or analyzed; the quantity of proteolytic enzymes present; etc. This degradation can produce circulating amounts of natriuretic peptides having reduced or lost biological function. The present invention provides, inter alia, assays designed to accurately measure biologically active natriuretic peptides, and compositions to inhibit a previously unknown pathway for degradation of natriuretic peptides.

Use of soluble flt-1 and its fragments in cardiovascular conditions

The present invention relates to materials and procedures for evaluating patients suffering from cardiovascular conditions, particularly acute coronary syndromes. In particular, an assay configured to measure the level of soluble FLT-1 in a patient sample, alone or in combination with one or more other markers, provides diagnostic and/or prognostic information. While applicable to diseases and conditions in which inflammation is generally manifested, the methods and compositions described herein are particularly applicable to acute coronary syndromes, including conditions selected from the group consisting of stable angina, unstable angina, non-ST-elevation non-Q wave myocardial infarction, ST-elevation non-Q wave MI, and transmural (Q-wave) MI.

Weatherproof joint cover for fabric roofs

Fabric restraining cables are anchored at opposite ends to a concrete ring of a roof structure. Each cable has a plurality of bearing plates spaced longitudinally therealong and secured to the upper portion thereof by U-bolts. Clamp mounting base plates also secured at one end by the U-bolts span the spaces between pairs of the bearing plates. Each base plate has a pair of lower clamp plates secured respectively along opposite edge portions thereof. Each lower clamp plate has an upper clamp plate secured thereto and clamping a beaded edge portion of a fabric panel along with upper and lower gaskets therefor. In several embodiments, each upper gasket is extended transversely outwardly from the cable, looped back over the respective row of upper clamp plates, and releasably joined to the opposite extended and looped back upper gasket to provide a joint cover between the opposite fabric panels.

Easily Attachable RFID Tag and Method of Making the Same

A location designation RFID tag for use in a storage facility includes an inlay, a first layer disposed on a first side of the inlay and having a first thickness, and a second layer disposed on a second side of the inlay. The first layer has a first thickness and the second layer has a second thickness. The inlay includes substrate, an antenna disposed on the substrate, and an integrated circuit disposed on the substrate. The location designation RFID tag may be easily and non-invasively placed and relocated on a floor of a storage facility in a manner that mitigates, and likely resolves, the issues experienced by known RFID tags when placed on a floor. Utilizing an inlay having a long, thin antenna, reduces the overall thickness of the location designation RFID tag, which allows layers to be disposed on the inlay that include a sufficient thickness to improve durability, mitigate detuning, and allow movable devices to readily pass over the location designation RFID tag.

Flavone acetic acid analogs and methods of use thereof

Compounds are described having a structure according to Formula I or Formula II: wherein: X is selected from the group consisting of O, NH, and S; Y is selected from the group consisting of O and S; m is from 1 to 3; n is from 1 to 5; R 1 and R 3 are each independently selected from the group consisting of H, hydroxy, lower alky, lower alkoxy, halo, amino, aminoalkyl, nitro, heteroaryl, —OC(═O)R 6 , —O(C═O)OR 6 ; and —O(C═O)N(R 6 ) 2 ; and R 2 is side chain such as an acetic acid side chain, where p is O to 4, R 5 is hydroxy, alkoxy or amino, and R 6 is H or lower alkyl, or a pharmaceutically acceptable salt thereof. The compounds are useful for the treatment of cancer.

Ridge vent with biocidal source

An improved ridge vent that includes a support, a cover, a housing, and a concealing structure provides ventilation for a building. The housing contains a biocidal source. Rainwater flows down the cover, into the housing, and over the biocidal source. The water treated with the biocidal source then flows out of the housing and down the roof, inhibiting the growth of mold, moss, bacteria, and fungus. The concealing structure hides the biocidal source from view.

Methods and compositions for measuring biologically active natriuretic peptides and for improving their therapeutic potential

Advanced mobile X-ray apparatus

L'invention concerne un appareil monté sur un chariot (12) et équipé d'un bras articulé (30) de support d'un tube de rayons X (52). Le poids du bras de support est équilibré par un contrepoids et articulé de manière à pouvoir positionner le tube sans qu' il soit nécessaire de déplacer le chariot. Le chariot comporte par ailleurs un berceau (13) permettant d'immobiliser le tube en position de rangement. Toutes les articulations du bras de support sont équipées de freins électro-magnétiques à disques. Une poignée (200) mobile à la partie antérieure du chariot et équipée de jauges de contraintes connectées à des circuits électriques de commandes de moteurs d'entraînement des roues permet de déplacer facilement le chariot. Application aux appareils de rayons X permettant de faire des radiographies de malades alités. The invention relates to an apparatus mounted on a cart (12) and equipped with an articulated arm (30) for supporting an x-ray tube (52). The weight of the support arm is balanced by a counterweight and articulated so that the tube can be positioned without the need to move the carriage. The trolley also includes a cradle (13) making it possible to immobilize the tube in the storage position. All the joints of the support arm are equipped with electro-magnetic disc brakes. A handle (200) movable at the front of the cart and equipped with strain gauges connected to electrical circuits for controlling the wheel drive motors allows the cart to be easily moved. Application to X-ray devices making it possible to take X-rays of bedridden patients.

Methods for the recovery and measurement of troponin complexes

The invention relates in part to methods and compositions for identifying the presence, measuring the amount, stabilizing, and facilitating recovery of troponin complexes or individual troponin isoforms in a sample.

Advanced mobile X-ray device.

IMPROVED X-RAY MOBILE APPARATUS

Diagnostic markers of acute coronary syndrome and methods of use thereof

The present invention relates to methods for the diagnosis and evaluation of acute coronary syndromes. In particular, patient test samples are analyzed for the presence and amount of members of a panel of markers comprising one or more specific markers for myocardial injury and one or more non-specific markers for myocardial injury. A variety of markers are disclosed for assembling a panel of markers for such diagnosis and evaluation. In various aspects, the invention provides methods for the early detection and differentiation of stable angina, unstable angina, and myocardial infarction. Invention methods provide rapid, sensitive and specific assays that can greatly increase the number of patients that can receive beneficial treatment and therapy, reduce the costs associated with incorrect diagnosis, and provide important information about the prognosis of the patient.

AGENT FOR REDUCING SKIN AND EYE IRRITATION FROM DETERGENTS

LA PRESENTE INVENTION EST RELATIVE A UNE FRACTION DE PROTEINES, PARTIELLEMENT HYDROLYSEES, HYDROSOLUBLES, CHARGEES POSITIVEMENT CONTENANT UNE FORTE CONCENTRATION EN AMINO-ACIDES BASIQUES AYANT UN POINT PI DE 7 A 12, UN INDICE DE GELIFICATION BLOOM DE ZERO ET UN POIDS MOLECULAIRE D'ENVIRON 600 A 12000. CETTE FRACTION EST UTILISABLE DANS UNE COMPOSITION DETERGENTE LIQUIDE PRESENTANT DES PROPRIETES DE COMPOSITION AYANT DES PROPRIETES D'IRRITATION REDUITE SUR LA PEAU ET LES YEUX EN RAISON DE LA PRESENCE DE LADITE FRACTION DE PROTEINES. THE PRESENT INVENTION RELATES TO A PROTEIN FRACTION, PARTLY HYDROLYZED, WATER-SOLUBLE, POSITIVELY CHARGED, CONTAINING A HIGH CONCENTRATION OF BASIC AMINO ACIDS HAVING A POINT PI OF 7 TO 12, A BLOOM GELING INDEX OF ZERO AND A MOIRLECONULAR WEIGHT 600 TO 12000. THIS FRACTION CAN BE USED IN A LIQUID DETERGENT COMPOSITION PRESENTING COMPOSITION PROPERTIES HAVING REDUCED IRRITATION PROPERTIES ON THE SKIN AND EYES DUE TO THE PRESENCE OF THE SAID FRACTION OF PROTEINS.

Use of b-type natriuretic peptide as a prognostic indicator in acute coronary syndromes

The present invention relates to materials and procedures for evaluating the prognosis of patients suffering from acute coronary syndromes. In particular, the level of BNP, or a marker related to BNP, in a patient sample, alone or in combination with one or more other prognostic markers, provides prognostic information useful for predicting near-term morbidity and/or mortality across the entire spectrum of acute coronary syndromes, including unstable angina, non-ST-elevation non-Q wave myocardial infarction, ST-elevation non-Q wave MI, and transmural (Q-wave) MI.

IMPROVED X-RAY MOBILE APPARATUS

L'invention propose un appareil mobile de rayons X, comprenant un chariot; un bras articulé de support d'un tube de rayons X fixé au chariot et comprenant une pluralité d'éléments de support (40, 44) accouplés en pivotement; un frein à disques (100), à commande électromagnétique, ayant un logement (08) et un collier de serrage (110), le logement étant placé concentriquement autour d'un arbre commun (102) fixé à l'un des deux éléments voisins du bras de support et étant par ailleurs fixé à l'autre des deux éléments voisins et le collier (110) étant fixé à l'arbre commun (102), de façon que, lorsque le frein est serré, le mouvement angulaire relatif du logement (108) et du collier (110) soit empêché et de ce fait, celui des deux éléments voisins de support. Application aux appareils de rayons X permettant de faire des radiographies de malades alités. The invention provides a mobile x-ray apparatus, comprising a cart; an articulated support arm for an x-ray tube fixed to the carriage and comprising a plurality of support members (40, 44) pivotally coupled; an electromagnetically controlled disc brake (100) having a housing (08) and a clamp (110), the housing being placed concentrically around a common shaft (102) attached to one of the two neighboring elements of the support arm and being otherwise fixed to the other of the two neighboring elements and the collar (110) being fixed to the common shaft (102), so that, when the brake is applied, the relative angular movement of the housing (108) and the collar (110) is prevented and therefore that of the two neighboring support elements. Application to X-ray devices making it possible to take X-rays of bedridden patients.

Tightening wrench

Methods and compositions for measuring natriuretic peptides and uses thereof

The present invention describes compositions and methods designed to determine the presence or amount of natriuretic peptides, or their fragments, in a sample. The degradation of natriuretic peptides is an ongoing process that may be a function of, inter alia, the elapsed time between onset of an event triggering natriuretic peptide release into the tissues and the time the sample is obtained or analyzed; the quantity of proteolytic enzymes present; etc. This degradation can produce circulating amounts of natriuretic peptides having reduced or lost biological function. The present invention provides, inter alia, assays designed to accurately measure biologically active natriuretic peptides, and compositions to inhibit a previously unknown pathway for degradation of natriuretic peptides.

Treadmill control system

A microprocessor based exercise treadmill control system is disclosed which includes various features to enhance user operation. These features include programs operative to: permit a set of user controls to cause the treadmill to initially operate at predetermined speeds; permit the user to design custom workouts; permit the user to switch between workout programs while the treadmill is in operation; and perform an automatic cooldown program where the duration of the cooldown is a function of the duration of the workout or the user's heart rate. The features also include a stop program responsive to a detector for automatically stopping the treadmill when a user is no longer on the treadmill and a frame tag module attached to the treadmill frame having a non-volatile memory for storing treadmill configuration, and operational and maintenance data.

System and method for translumenal access

Cocaine derivatives and protein and polypeptide cocaine derivative conjugates and labels

Compounds are provided for the preparation of reagents, including labels which can be used in immunoassays of cocaine and cocaine metabolites. The compounds are derivatives of cocaine which are conjugated to antigenic proteins or polypeptides for the formation of antibodies for use in immunoassays. The compounds also may be conjugated to labels for use in immunoassays.

Cyclical process of fixing atmospheric nitrogen.

Method and apparatus for aligning a cylinder in an engraver

A method for aligning a cylinder support in an engraver includes a step of actuating a plurality of jaws to grip the cylinder support such that the cylinder support becomes automatically aligned in the engraver. The actuating step may further include the step of inserting the cylinder support a predetermined distance into a receiving cavity, where the predetermined distance may range from about 0-300 mm. The method is further characterized in that it may include steps of biasing the plurality of jaws to a predetermined position, energizing a cylinder to cause the plurality of jaws to move substantially simultaneously towards a rotating axis of the engraver; pivoting the pivot lever to cause the jaws to actuate toward and away from a rotational axis of the engraver; and/or lubricating the plurality of jaws with a lubricant and purging the lubricant associated with the plurality of jaws; and/or indexing each of the plurality of jaws to provide a desired travel range. In one embodiment, the cylinder support includes a support shaft located on an end of the cylinder, with the support shaft having a bearing journal thereon such that the actuating step may include the step of actuating the plurality of jaw members to clamp the bearing journal, thereby causing the cylinder to be aligned in the engraver.

Treadmill control system

A microprocessor based exercise treadmill control system is disclosed which includes various features to enhance user operation. These features include programs operative to: permit a set of user controls to cause the treadmill to initially operate at predetermined speeds; permit the user to design custom workouts; permit the user to switch between workout programs while the treadmill is in operation; and perform an automatic cooldown program where the duration of the cooldown is a function of the duration of the workout or the user's heart rate. The features also include a stop program responsive to a detector for automatically stopping the treadmill when a user is no longer on the treadmill and a frame tag module attached to the treadmill frame having a non-volatile memory for storing treadmill configuration, and operational and maintenance data.

Novel methods for the assay of troponin i and t and complexes of troponin i and t and selection of antibodies for use in immunoassays

Assay systems and specialized antibodies for the detection and quantitation of troponin I and troponin T in body fluids as an indicator of myocardial infarction. Since troponin I and T exist in various conformations in the blood, the ratios of the monomeric troponin I and T and the binary and ternary complexes, as well as which form of troponin present in the blood, may be related to the metabolic state of the heart. Disclosed is a system to determine the presence of a troponin form or a group of troponin forms in a sample of whole blood, serum or plasma. Disclosed is a stabilized composition of troponin; the stabilized composition can comprise a stabilized composition of troponin I, wherein the troponin I is oxidized, the troponin I can be unbound or the troponin I can be in a complex. Disclosed is a method for improving the recovery of troponin I or T from a surface used in immunoassays. Also disclosed are antibodies which recognize, unbound troponin forms, the forms of troponin in binary complexes, the ternary complex of troponin I, T and C, and the conformations of troponin I having intramolecularly oxidized and reduced cysteines.

Therapeutic combination of daptomycin and protein synthesis inhibitor antibiotic, and methods of use

A therapeutic combination comprises an antibacterially effective amount of daptomycin, and an amount of protein synthesis inhibitor antibiotic effective to prevent the development of daptomycin non-susceptibility in bacteria. Related combination therapies and methods are also included.

Probing with backside emission microscopy

Rapid evaluation of the ratio of biological molecules

The invention relates in part to novel methods of rapidly determining the ratio of biological molecules. The invention also relates in part to a kit for rapidly determining the ratio of biological molecules.

Corrosive liquid detection sensor cable and method

A cable suitable for detecting the presence of corrosive liquids is disclosed. In an embodiment the cable includes two sensing wires wrapped around a core member, at least one of the sensing wires being surrounded by a non-conductive surface layer. In an alternate embodiment the cable includes two sensing wires wrapped around a core member, the sensing wires and core member being encapsulated by a non-conductive surface layer. Preferably, the cable includes insulating wires for detecting the location of a leak. When a corrosive liquid contacts the sensing wires of the cable an electrical connection is created between them.

Exercise treadmill

To improve tracking, an exercise treadmill is provided with a frame including molded plastic pulleys, having an integral gear belt sprocket, an endless belt extending around the pulleys and a motor operatively connected to the rear pulley to drive the belt. The pulleys are molded out of plastic and have a diameter of approximately nine inches. A deck underneath the running surface of the belt is supported by resilient members. A positive lateral belt tracking mechanism is used to correct the lateral position of the belt. A belt position sensor mechanism is used in combination with a front pulley pivoting mechanism to maintain the belt in the desired lateral position on the pulleys. The exercise treadmill also includes a lift mechanism with an internally threaded brass or steel sleeve engaged to vertically aligned nonrotating screws. A user display of foot impact force on the belt is also provided.

Novel phencyclidine derivatives and protein and polypeptide phencyclidine derivative conjugates and labels

The present invention is directed to novel PCP derivatives which are synthesized for the covalent attachment to antigens or receptors (proteins or polypeptides) for the preparation of antibodies or receptors to PCP and PCP analogue metabolites. The resulting novel antigens may be used for the production of antibodies or receptors using standard methods. Once generated, the antibodies and the novel derivatives which are covalently attached to proteins, polypeptides or labels may be used in the immunoassay process.

Optical dual function joystick

A joystick actuator for controlling the positioning of objects, for instance, displays on CRTs, having a pivotally mounted control stick operatively engaging and driving a pair of optical-mask members. The optical-mask members are retained for rectilinear sliding motion relative to fixed mounted opto-switches and include spaced fins positioned to interrupt light communication within respective opto-switches. Positioning of the opto-switches and spacing of the mask fins are selected to provide successive unblocking of the interrupted light communication as the control column is displaced from neutral thereby encoding both the direction and magnitude of stick deflection.