COMPOUNDS WITH ANTI-PARASITE ACTIVITY AND MEDICAMENTS CONTAINING SAME

L'invention vise des composés présentant une activité anti-parasitaire, notamment antipaludique, caractérisés en ce qu'ils répondent à la formule générale (I)Applications notamment comme composés à activité anti-parasitaire. The invention relates to compounds having an anti-parasitic activity, especially antimalarial, characterized in that they correspond to the general formula (I) Applications in particular as compounds with anti-parasitic activity.

BIS-2-AMINOPYRIDINES, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS

BIS-2-AMINOPYRIDINES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATIONS

Bis-2-aminopyridine substituées de formule générale (I), (CF DESSIN DANS BOPI) dans laquelle: Q représente un groupement alkyle en C6 -C20 , un groupement aryle, éventuellement substitué, ou un groupement cycloalkyle, et forme, entre les 2 noyaux pyridine, un enchaînement hydrocarboné comprenant au total de 6 à 34 atomes de carbone, n est un nombre compris entre 0 et 7, R1 , R2 , R3 , R4 identiques ou différents, représentent un atome d'hydrogène, un groupement alkyle en C1 -C6 , linéaire ou ramifié, éventuellement substitué, un groupement aryle, éventuellement substitué par un ou plusieurs atomes d'halogène, ou des radicaux alkyle en C1 -C6 ou alcoxy en C1 -C6 , un groupement benzyle, un groupement thiényle, un groupement furyle, un atome d'halogène, un groupement alcoxy ou benzyloxy, à la condition qu'au moins l'un des radicaux R1 , R2 , R3 ou R4 ne soit pas un atome d'hydrogène, lorsque Q représente un enchaînement (CH2 )m avec m compris entre 6 et 20, ainsi que leurs sels d'addition. Procédé de préparation et applications des bis-2-aminopyridines substituées ou non, comme médicament, notamment comme médicaments actifs sur les parasitoses intra-érythrocytaires, telles que le paludisme ou la babésiose (ou piroplasmose). Substituted bis-2-aminopyridine of general formula (I), (CF DRAWING IN BOPI) in which: Q represents a C6 -C20 alkyl group, an aryl group, optionally substituted, or a cycloalkyl group, and form, between the 2 pyridine rings, a hydrocarbon sequence comprising a total of 6 to 34 carbon atoms, n is a number between 0 and 7, R1, R2, R3, R4 which are identical or different, represent a hydrogen atom, a C1 alkyl group -C6, linear or branched, optionally substituted, an aryl group, optionally substituted by one or more halogen atoms, or C1 -C6 alkyl or C1 -C6 alkoxy radicals, a benzyl group, a thienyl group, a group furyl, a halogen atom, an alkoxy or benzyloxy group, on condition that at least one of the radicals R1, R2, R3 or ...

Compounds with antiparasitic activity and medicines containing same

The invention concerns compounds with antiparasitic, in particular antimalarial, activity, characterized in that they are of general formula (I). The invention is in particular useful as compounds with anti-parasitic activity.

COMPOUNDS WITH ANTI-PARASITE ACTIVITY AND MEDICAMENTS CONTAINING SAME

BENZYL-PYRIMIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM

BIS-2-AMINOPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE FOR COMBATING PARASITOSIS

Compounds with antiparasitic activity and medicaments containing them

The invention concerns compounds with antiparasitic, in particular antimalarial, activity, characterised in that they are of general formula (1). The invention is in particular useful as compounds with anti-parasitic activity.

ANTI-MALARIA AND ANTIBABESIOSIS AGENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Compounds with antiparasitic activity and medicines containing same

The invention concerns compounds with antiparasitic, in particular antimalarial, activity, characterized in that they are of general formula (I). The invention is in particular useful as compounds with anti-parasitic activity.

Remote status forwarding in a distributed cross-connection system

A method and system for providing component status of a local or receiving component to a distributed component in a communication network is provided. The design determines defect status for the local or receiving component and cross connects the defect status for the local component to at least one distributed component separate from the local or receiving component, typically using a unified cross connect design. The design also alters a connection matrix maintained within each distributed component to indicate defect status for a transmit channel between the local component and the remote component. Remote defect indications may be determined within the design and provided to the remote components.

Compounds with antiparasitic activity and medicines containing same

Diamidine derivatives of formula (I) and their salts are new. Amidine derivatives of formula (I) and their salts are new. [Image] X : a group of formula (ii) or R 4; Z : -(CH 2) m-; m : 8 - 21; n : 0 or 1; Y : R 3 or a group of formula (iii); R 1 and R' 1H, alkyl, aryl, OH, O-alkyl, O-aryl, OCO-alkyl, OCO-aryl, O-CO-O-(or S or NH)-alkyl, O-CO-O-(or S or NH)-aryl, PO-(O-alkyl or O-aryl) 2, CO-O-CH 2-aryl, or cycloalkyl; R 2 and R' 2H, alkyl, CO-O-CH 2-aryl, CO-O-alkyl, or cycloalkyl; R 3 and R' 3H, alkyl, aryl, CO-O-alkyl, CO-O-aryl, COO-CH(R)-O-CO-alkyl, PO(O-alkyl, or O-aryl, or ONa) 2, or CO-O-CH(R)-aryl; R : H or alkyl; NR 1R 2, NR' 1R' 2, NR 2R 3, NR' 2R' 3a heterocycle, in which R 2 and R 3 and/or R' 2 and R' 3 may be doubly bonded to the nitrogen atom; R 4 and R' 4H or alkyl; R 1R 4, R' 1R' 4-(CH 2) p-; R 4R 2, R' 4R' 2-(CH 2) p; p : 3 - 5; and provided that: (1) when X is a group of formula (ii), then Y is R 3; and (2) when X is R 4, then Y is a group of formula (iii). [Image] Independent claims are also included for the preparation of compounds of formulae (V), (X), (VI) and (VIII). [Image] R anot defined. ACTIVITY : Protozoacide. 1,12-bis(imidazolin-2-yl) dodecane (Ib) was given orally and intraperitoneally to mice infected with Plasmodium vinckei. The dose that cleared 50 % of the infection (ED50) was 3.4 mg/kg i.p and 62 mg/kg p.o. MECHANISM OF ACTION : Not given in source material.

Mittel gegen malaria und babesia und diese enthaltende pfarmazeutische zubereitungen

Vorprodukte von bis-quaternären ammoniumsalzen und deren verwendung als prodrugs mit anti- parasitärer wirkung

Bis-2-aminopyridine, verfahren zu ihrer herstelung und ihre verwendung zur bekämpfung von parasitosen