30-08-2018 дата публикации
Номер: US20180243371A1
Принадлежит:
The invention relates to a mussel adhesive protein (MAP) and an application thereof in inhibiting catarrh, and specifically, to applications of a MAP or a product thereof in oral mucositis, rhinitis, otitis media, pharyngitis, laryngitis, bronchitis, esophagitis, gastritis, enteritis, cervicitis, endomyometritis, inflammation resulting from inhalation injury, and oral cavity cancer, nasopharyngeal cancer, carcinoma of middle ear, conjunctival cancer, laryngeal cancer, lung cancer, esophageal cancer, stomach cancer, bowel cancer, cervical cancer, endometrial cancer, and other cancers resulting from the inflammation. The MAP can inhibit symptoms such as flush, fever, swell, and pain owing to catarrh, facilitating healing, relieving itch and pain, and having broad applications in the fields of medicines, cosmetics, medical products, disinfection products, healthcare products, foods, and household goods. 116.-. (canceled)17. A method for treating mucosal inflammation , the method comprising:administering to a subject having mucosal inflammation an effective amount of a composition comprising a mussel adhesive protein (“MAP”), wherein said administering treats the mucosal inflammation.18. The method according to claim 17 , wherein the MAP comprises one or more of the sub-types selected from the group: Mytilus edulis foot protein (“mefp”) subtypes mefp-1 claim 17 , mefp-2 claim 17 , mefp-3 claim 17 , mefp-4 claim 17 , mefp-5 claim 17 , mefp-6; collagens pre-COL-P claim 17 , pre-COL-D claim 17 , and pre-COL-NG; and mussel feet matrix proteins PTMP and DTMP.19. The method according to claim 17 , wherein the MAP comprises one or more of the sub-types selected from the group mefp-1 claim 17 , mefp-2 claim 17 , mefp-3 claim 17 , mefp-4 claim 17 , mefp-5 claim 17 , and mefp-6.20. The method according to claim 19 , wherein the MAP comprises mefp-1.21. The method according to claim 17 , wherein the MAP is present in the composition at a concentration of 0.1 to 15.0 mg/ml.22. The ...
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