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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 195. Отображено 195.
20-04-2011 дата публикации

Distributed deployment method for large-scale wireless sensor network testing and debugging

Номер: CN0102026227A
Принадлежит:

The invention discloses a distributed deployment method for a large-scale wireless sensor network testing and debugging distributed deployment method. The method is suitable for the establishment of debugging and texting network of the wireless sensor network. The method comprises the following steps: the nodes to be tested in a wireless sensor network are connected with different adapter plates according to different interface modes, the adapter plates are utilized to ensure that the sensor nodes of different kinds and different operating systems are compatible; the nodes are all connected with debugging data collecting and processing gateways through USB ports, the collecting and processing gateways are connected with a control server through an Ethernet or a wireless network; and a time synchronization scheme is adopted to constitute a distributed deployment architecture. The number of the data collecting and processing gateways can be increased to realize the large-scale network extension ...

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17-03-2010 дата публикации

Single one-dimensional nano-material photoluminescence angle resolution and measurement system

Номер: CN0101672783A
Принадлежит:

The invention discloses a single one-dimensional nano-material photoluminescence angle resolution and measurement system, belonging to the nano-material optics technical field. The system comprises alight source, an optical element 1, an optical element 2 and a light analytical instrument, wherein excitation light from the light source passes through the optical element 1 and then is used for exciting the one-dimensional nano-material to emit fluorescence; and the fluorescence passes through the optical element 2 and then is sent to the light analytical instrument. The system is characterizedin that one of the optical element 1 and the optical element 2 is a micro-objective, the other one is a convergent lens, or the optical element 1 and the optical element 2 are the micro-objectives. In the system, the optical element 2 is fixed; one of the included angle of the c axis of the nano-material and the optical axis of the optical element 2 as well as the included angle of the c axis ofthe ...

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17-05-2000 дата публикации

Thermoelectric converters

Номер: GB0002343788A
Принадлежит:

The converter comprises at least one element 20 of Fermi gas material connected to at least one element 22 of Fermi liquid material, so forming a Fermi gas/Fermi liquid interface. The interface provides for a phase change of charge carriers as the charge carriers move across the interface.

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15-12-2010 дата публикации

Method for detecting safety of geomembrane weld joint by utilizing electric sparks

Номер: CN0101915649A
Принадлежит:

The invention relates to a method for detecting the leakproofness of an extruding single-rail weld joint of polyethylene geomembrane, which is characterized by comprising the following steps of: (1) laying a metal wire at a weld joint of a detection area before welding; (2) scanning the weld joint by adopting an electric spark detector; and (3) judging whether the electric sparks appear or not, if the electric sparks do not appear, indicating that the leakproofness of a scanned area is excellent, and if the electric sparks appear, indicating that the leakproofness of the scanned area is disqualified. Through the method, the leakproofness of the weld joint of the polyethylene geomembrane can be detected quickly and accurately.

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01-02-2012 дата публикации

Vacuum-adsorption type plug-seedling precision seed planter

Номер: CN0202127603U

The utility model discloses a vacuum-adsorption type plug-seedling precision seed planter which comprises a conveying device (8), a plug feeding device (1), a covering and flattening device (3), a leveling device (4), a plug pressing device (5) and a vacuum-adsorption planting device (6), wherein the conveying device (8) is arranged on a frame (2) and driven by a speed reducing motor (7); the plug feeding device (1), the covering and flattening device (3), the leveling device (4), the plug pressing device (5) and the vacuum-adsorption planting device (6) are arranged above the conveying device in the sequence from the input end of the conveying device to the output end of the conveying device, a synchronous transmission device (12) is connected between the plug pressing device (5) and the vacuum-adsorption planting device (6), and transverse push rods (10) are uniformly distributed on the conveying surface of the conveying device. The vacuum-adsorption type plug-seedling precision seed ...

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25-02-2004 дата публикации

Hepatitis c virus assays

Номер: AU2003256404A8
Принадлежит:

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12-11-2008 дата публикации

Electrochemical synthesis method of fluorinated glyoxaline

Номер: CN0101302621A
Принадлежит:

The invention relates to an electrochemical synthesis method for fluorinated imidazole. The method comprises the following steps that: imidazole is used as raw material; acetonitrile is used as solvent; triethylamine trifluoro-hydrogen is used as electrolyte and a fluorine supply source; graphite is used as an electrode; under the condition of nitrogen protection, potentiostatic electrolysis is carried out to the raw material; after electrolytic solution is neutralized, extracted, dried, fractionated and purified, the fluorinated imidazole is obtained. The yield of the method can reach over 50 percent. The method has the advantages that: the method is simple in device, low in cost, mild in fluorination condition and easy to operate and control, uses no high-toxic or dangerous reagent, is beneficial to environment protection, and achieves the aim of clean production; and the electrochemical synthesis method only consumes electric energy, does not pollute environment, and has significant ...

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23-12-2009 дата публикации

Ultra-roughening treating agent for cuprum surface

Номер: CN0100574568C
Принадлежит:

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28-05-2003 дата публикации

Thermoelectric converter

Номер: GB0002343788B

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10-10-1997 дата публикации

Thermo-electric boiler arrangement

Номер: AU0002033897A
Принадлежит:

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03-06-1998 дата публикации

Self-excitation reaction apparatus for clarifying treatment of water

Номер: CN0001183314A
Автор: GAO MIN, YAN HUA, MIN GAO, HUA YAN
Принадлежит:

A water treating apparatus is composed of self-excited cyclic reaction system, settling separation system and mud discharge system, and features high reaction speed and quality, simple structure, less consumption and high treating effect. It can be widely used for coagulating colloidal substance, decolouring, deodourising, removing impurities, softening water, and clarifying water.

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02-03-2005 дата публикации

Nano carbon material modified copper base catalyst and its preparing method

Номер: CN0001586718A
Принадлежит:

The present invention belongs to the field of chemical technology, and especially one kind of copper base catalyst with nanometer carbon material as co-catalyst for vapor reformation of methanol to prepare hydrogen and its preparation process. The catalyst is prepared through the process including the steps of: compounding 0.1 M solution of Cu/Zn/Al nitrate; compounding 0.1 M solution of sodium carbonate, dropping the 0.1 M solution of Cu/Zn/Al nitrate and 0.1 M solution of sodium carbonate in the same rate into reactor with nanometer carbon material for co-precipitation under strong stirring and 60 deg.c to obtain carbonate coprecipitate containing nanometer carbon material; washing, drying, roasting, etc. The prepared catalyst has unique porous structure of great specific surface area, high low temperature activity and high hydrogen selectivity, and may be used in preparing reformed product with hydrogen content up to 75 % and CO content lower than 0.1 %.

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16-12-1998 дата публикации

Thermo-electric boiler arrangement

Номер: GB0002326223A
Принадлежит:

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07-10-2009 дата публикации

Method for installing and hoisting gas-insulated metal closed power transmission line in shaft and device thereof

Номер: CN0101552430A
Принадлежит:

The invention relates to the field of large and medium hydropower projects, in particular to a method for installing and hoisting gas-insulated metal closed power transmission line in a shaft, and a device thereof. The method is characterized in that the installation of the gas-insulated metal closed power transmission line GIL device (4) adopts two independent procedures by using a hoisting device with large hoisting height, namely, preassembly procedure and final installation procedure to carry out installation and hoisting. The method has the advantages of simple structure, safety, reliability and obvious effect and has great popularization and application values in solving the technical problems of hoisting the GIL device in a highly vertical shaft safely, fastening the installation of the GIL device, arranging equipment and the like.

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02-11-2011 дата публикации

Microbiological additive for ruminants and preparation technology thereof

Номер: CN0102228138A
Принадлежит:

The invention relates to a microbiological additive for ruminants and a preparation technology thereof. The additive is characterized by culturing respectively Saccharomyces cerevisiae, Candida utilis and Bacillus subtilis in a liquid culture medium to obtain Saccharomyces cerevisiae fermentation bacterial liquid, Candida utilis fermentation bacterial liquid and Bacillus subtilis fermentation bacterial liquid, mixing the three fermentation bacterial liquids, and then carrying out a fermentation process of the three fermentation bacterial liquids on a solid culture medium to obtain a mixed culture, wherein in the mixed culture, a polypeptide content is equal or greater than 5.3 g/Kg; a beta-glucan content is equal or greater than 125 mg/Kg; by weight, an amino acid content is equal or greater than 16.5%; and by weight, an organic acidity content is equal or greater than 3.45%. The invention also relates to a preparation method of the microbiological additive for ruminants.

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25-02-2004 дата публикации

HEPATITIS C VIRUS ASSAYS

Номер: AU2003256404A1
Принадлежит:

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07-04-2010 дата публикации

Two-dimensional laser autocollimator

Номер: CN0101691998A
Принадлежит:

The invention relates to a two-dimensional laser autocollimator. The autocollimator comprises a generation device of left-hand and right-hand circular polarized light with reticule information on a horizontal optical axis, as well as a first common beam splitter prism, a collimating object lens and a target reflector which are sequentially arranged in the horizontal optical axis direction and the advance direction of a 'cross' light beam, wherein the generation device generates the left-hand and right-hand circular polarized light with the reticule information to form centrosymmetric 'cross' light beam output; the beam-splitting plane of the first common beam splitter prism is in a 45-degree included angle with the horizontal optical axis; a first lambda/4 wave plate, a first polarization splitting prism and a horizontal linear array CCD are sequentially arranged on one side of the first common beam splitter prism; and a vertical linear array CCD is arranged in the reflected light direction ...

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02-12-2009 дата публикации

Solar air-conditioning bus shelter

Номер: CN0101591984A
Принадлежит:

The invention relates to a solar air-conditioning bus shelter. The bus shelter comprises a ceiling supported by upright posts; a solar cell plate is arranged on the ceiling, and a storage cell and an air-conditioning device are arranged under the ceiling; a power supply output end of the solar cell plate is connected with a power supply input end of the storage cell, of which a power supply output end is connected with a power supply input end of the air-conditioning device; and an air outlet of the air-conditioning device aims at people who wait for a bus below the ceiling. The method utilizes the solar energy to supply the air-conditioning energy for the bus shelter, which brings comfortable coolness to the people who wait for the bus below the ceiling.

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14-09-2011 дата публикации

Parallel non-zero coefficient context modeling method for binary arithmetic coding

Номер: CN0102186087A
Принадлежит:

The invention discloses a parallel non-zero coefficient context modeling method for binary arithmetic coding, and relates to a context modeling technology for video coding. The method is proposed to solve the problem that the data throughput rate of a coding system is reduced because the conventional binary arithmetic coding generates a data dependency relationship on the context in the context modeling process of non-zero coefficients. The method comprises the following steps of: 1, defining the number of coefficients and non-zero coefficients in a transform quantification block; 2, performing binarization on the non-zero coefficients to obtain a bin sequence; 3, performing context modeling on a first context according to the position information of the non-zero coefficients and the number of the non-zero coefficients in the transform quantification block; 4, calculating the probability distribution of the non-zero coefficients, the absolute value of which is abs (Li) in the first context ...

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25-05-2005 дата публикации

Radio module testing machine and method of proceeding radio module test using said machine

Номер: CN0001620155A
Автор: GAO MIN, MIN GAO
Принадлежит:

A radio module tester for testing at least one RF module contains transmitting RF multi-channel selector for transmitting the first RF signal according to first control signal, RF coupler for receiving first RF signal and dividing it into verification RF signal and measurement RF signal, receiving RF multi-channel selector for receiving verification RF signal and transmitting verification RF signal according to second control signal, radio receive module for generating corresponding verification value according to verification RF signal, integrated controller for controlling the corresponding relation between radio RF module and radio receive module, analog signal measuring unit for generating corresponding measurement value according to received measurement RF signal, and process unit for receiving measurement value and verification value to judge whether the radio RF module is qualified product or not.

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20-04-2011 дата публикации

Intelligent network business implementing system and method for preventing user identification from being stolen

Номер: CN0101330756B
Принадлежит:

The invention relates to an intelligent network service realization system and a method for preventing user identity from being embezzled. The realization method comprises the following steps: a calling service MSC/SSP is increased in the normal process of the intelligent network service to report an IMEI number to a user; when the IMEI number reported by the user is different from an IMEI numberpreserved in a calling home area SCP, the calling home area SCP informs the calling service IP that the user is prompted to enter a service password; the calling home area SCP determines whether to continue the calling according to the consistency between a judgment service password and a saved service password. The invention provides an intelligent network service for enhancing the legal identity of a protected user; on the premise of changing an original authentication system, an IMSI is incident on the IMEI; furthermore, the simultaneous confirmation of a unit and a card is ensured when the unit ...

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22-12-2010 дата публикации

Power control method and device of wireless local area network access point device

Номер: CN0101925167A
Принадлежит:

The invention discloses a power control method of a wireless local area network access point device, which comprises the following steps: using the wireless local area network access point device (AP) to obtain the current signal intensity or the data transmission quality; comparing the obtained signal intensity or the data transmission quality with a preset threshold, and obtaining the comparison result; and determining whether to adjust the transmission power of the wireless local area network access point device or not according to the comparison result. The invention further discloses a power control device of the wireless local area network access point device, which can realize energy conservation of the wireless local area network access point device through the flexible control of the transmission power.

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29-06-2011 дата публикации

Distributed interactive method for large-scale wireless sensor network

Номер: CN0102111796A
Принадлежит:

The invention discloses a distributed interactive method for a large-scale wireless sensor network. In the invention, a highly-expandable distributed network structure mode is adopted, thus a custom interface at which a user is allowed to access and control a network node is provided for a large-scale disorderly distributed wireless sensor network; and data monitoring and control of one or multiple nodes are supported at the same time, and the nodes in the sensor network are not required to be distributed according to a specific topological structure. Access nodes are automatically identified by using a node identification mode, and a proper interactive algorithm is selected for the access nodes; through the interface, the user can directly observe the real-time inner data and communication information of the nodes, and the real-time inner data and communication information comprise inner voltage information of the nodes, the value of a data structure in a node use program and the data ...

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30-03-2011 дата публикации

Zeolite biological treatment agent special for recycling of livestock and poultry manure feed

Номер: CN0101990983A
Автор: Cheng Wending, Gao Min
Принадлежит:

The invention discloses a zeolite biological treatment agent special for recycling of an organic waste feed, such as livestock and poultry manure and the like, which is mainly used for eliminating pollution to environment by the organic waste feed, such as the livestock and poultry manure and the like in the field of development and environmental protection of the recycling of the organic waste feed, such as the livestock and poultry manure and the like, in the field of livestock and poultry, and mainly solves the technical problems such as deodorizing, sterilizing, zymolysis and the like in a recycling process of the organic waste feed, such as the livestock and poultry manure and the like. By adopting a technical route of combining beneficial microorganism anaerobic fermentation and feed zeolite physical adsorption technology, the biological treatment agent is formed by selecting compound beneficial microorganisms such as lactobacillus, saccharomycete, photosynthetic bacteria and the ...

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31-05-2000 дата публикации

Equipment for brewing fruit spirit

Номер: CN0001254752A
Принадлежит:

An equipment for producing fruit spirit features that the crusher, mixer and fruit juice pump are communicated serially and then with internal cavity of fermentor, said internal cavity is communicated via yeast pump to yeast activating tank, the top and bottom ends of said internal cavity are communicated via circulating pump to each other and then via concentrated juice pump to the internal cavity of the tower still of 3-stage distilling tower, and the tower stilles of stage-1, stage-2 and stage-3 distilling towers are respectively communicated to the tower sections of the stage-3, stage-1 and stage-2 distilling towers. Its advantages are simple structure and rich nutrients and the characteristics of both grains spirit and fruit wine for the finished wine.

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18-05-2011 дата публикации

Electrical energy management method of wireless sensor node

Номер: CN0102065456A
Принадлежит:

The invention discloses an electrical energy management method of a wireless sensor node, comprising the following steps of: on the basis of the traditional wireless sensor network node, integrating an electrical energy management module and an enhanced general USB (Universal Serial Bus) communication module; controlling independent on-off of a power supply of a function unit in a node and acquiring the current of a main module of the traditional wireless sensor network node unit by the electrical energy management module unit; and realizing the communication between the traditional wireless sensor network node unit and an upper computer and the communication between the electrical energy management module unit and the upper computer by the enhanced general USB communication module, thereby realizing the electric energy management comprising the electrical energy control and the acquisition function of electrical energy, that is to say, achieving the electrical energy control and the calculation ...

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22-02-2012 дата публикации

Compound preparation for treating depression

Номер: CN0102000334B
Принадлежит:

The invention discloses a compound preparation for treating depression with the traditional antidepressant and curcumin as active components; the traditional antidepressant is a nonselective reuptake inhibitor or a selective 5-hydroxytryptamine reuptake inhibitor, wherein the nonselective reuptake inhibitor is desipramine, the selective 5-hydroxytryptamine reuptake inhibitor is fluoxetine, and the mass ratio of the traditional antidepressant to the curcumin can concretely be 2:1 or 4:1. In the compound preparation for treating the depression, low dosage curcumin and low dosage desipramine or fluoxetine are combined, thereby counteracting the adverse effects caused by blood sugar rise and displaying stronger antidepressant activity, and therefore, the compound preparation has good application prospect.

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25-08-2010 дата публикации

Method for preparing small-size optical microcavities

Номер: CN0101811662A
Принадлежит:

The invention discloses a method for preparing small-size optical microcavities and belongs to the field of optical microcavity preparation. The method of the invention comprises: 1), preparing nanowires or nanorods of a selected material by using a micro/nano preparation method; 2), selecting needed nanowires or nanorods and determining the width and position of cutting lines; and 3), cutting the selected nanowires or nanorods by using a micro/nano processing method according to the width and position, which are determined by the step 2), of the cutting lines to obtain the needed optical microcavities. Compared with the prior art, the method can prepare optical microcavities with small, accurate and controllable cavity sizes. And the process of the method can be realized easily and effectively.

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04-11-2009 дата публикации

Method for generating and using automatic test script

Номер: CN0101571798A
Принадлежит:

The invention discloses a method for generating and using an automatic test script. The method for generating the automatic test script is realized in three modules. The method comprises the followingsteps: generating a calling function relation; designing a relative test case; obtaining the calling function relation and the test case; traversing functions from a bottom layer until the function at a top layer is contained; extracting the current traversed function set to be written in a hollow script and writing an inlet function in the script; inserting a code at the opening part of the inlet function so as to read a case; inserting a code at the tail part of the inlet function so as to output a test result; and finally, generating and operating the script. The method for generating andusing the automatic test script can not influence the test effect due to the technical level of an operator and improves the reliability of case execution and the consistency of a regression test andthe ...

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28-10-1998 дата публикации

Water treating apparatus for clarification by self-excition reaction

Номер: CN0002295519Y
Автор: GAO MIN, YAN HUA, MIN GAO, HUA YAN
Принадлежит: GAO MIN

The utility model relates to a water clarifying processing device of a sludge circulation and self-excition type, which is composed of a self-excition circular reaction system, a settlement separation system, a sludge discharging system, etc. Compared with the existing mechanical accelerated clarifying ponds and hydraulic circular clarifying ponds, the utility model has the advantages of quick reaction speed, reasonable energy arrangement, high reaction quality, good water yielding effect, low medicine consumption, wide raw water adaption range, simple structure, less investment and easy maintenance. The utility model is an ideal water processing device which is broadly used in the water quality clarifying process such as the coacervation, the decolorization and the deodorization of colloidal substances, the removing, the softening and the alkali reduction of alkali earth salt class, the iron and the manganese removing, the chemical treatment of sewerage, etc.

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10-09-2014 дата публикации

HEPATITIS C VIRUS INHIBITORS

Номер: AR0000089711A1
Принадлежит:

Reivindicación 1: Una combinación, caracterizada porque comprende un compuesto dirigido a NS5A y un sinergista NS5A, que, cuando se administra, proporciona actividad anti-HCV sinérgica contra variantes que contienen mutaciones que confieren resistencia al compuesto dirigido a NS5A solo.

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05-05-2010 дата публикации

Mobile telephone instant communication and file sharing system based on Ad Hoc networking technology

Номер: CN0101702791A
Принадлежит:

The invention relates to a system which is based on Ad Hoc networking technology, does not need a fixed wireless network access equipment for support, adopts a wireless mobile terminal for fast, intelligent and automatic networking and realizes the functions of instant communication, file sharing and media file previewing among mobile telephones . The system can be realized by automatic and intelligent networking among mobile telephones without manual settings or additional wireless network access equipment (as shown in the figure), an IP addresses is assigned for terminals to complete the communication, and the system automatically updates and maintains a friend list. Therefore, the system realizes the functions of instant communication, file sharing and media file previewing among intelligent mobile telephone terminals without requiring extra expenses.

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11-09-2018 дата публикации

produto de proteína adesiva de mexilhão e aplicações do mesmo na supressão de inflamações de pele

Номер: BR112018000953A2
Принадлежит:

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28-04-2010 дата публикации

Method, device and system for processing data flow in WLAN (Wireless Local Area Network)

Номер: CN0101699899A
Автор: Gao Min, Liu Xiaoli
Принадлежит:

The invention discloses a method for processing data flow in WLAN (Wireless Local Area Network). The method comprises: receiving at least one data flow issued by a network side, and obtaining the interface marker of a wireless interface which transmits the data flow; determining the priority marker arranged to correspond to the obtained interface marker according to the preset configuration information of the wireless interface priority; attributing the received data flow the priority queue corresponding to the priority marker, and processing the data flow according to the processing mode of the priority queue; therefore, the priority of each data flow can be exactly judged, thus effectively improving the service quality of the system. The invention also discloses a wireless access device and a wireless communication system.

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14-07-2016 дата публикации

HEPATITIS C VIRUS INHIBITORS

Номер: US20160199355A1
Принадлежит:

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein. 2. The combination of which comprises two or more pharmaceutically acceptable carriers.3. The combination of wherein the NS5A-targeting compound and the NS5A synergist are combined in the same pharmaceutically acceptable carrier.4. A composition comprising a combination of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , and a pharmaceutically acceptable carrier.5. The composition of further comprising one or two additional compounds having anti-HCV activity.6. The composition of wherein at least one of the additional compounds is an interferon or a ribavirin.7. The composition of wherein the interferon is selected from interferon alpha 2B claim 6 , pegylated interferon alpha claim 6 , pegylated interferon lambda claim 6 , consensus interferon claim 6 , interferon alpha 2A claim 6 , and lymphoblastoid interferon tau.8. The composition of wherein at least one of the additional compounds is effective to inhibit the function of a target selected from HCV protease claim 5 , HCV polymerase claim 5 , HCV helicase claim 5 , HCV NS4B protein claim 5 , HCV entry claim 5 , HCV assembly claim 5 , HCV egress claim 5 , HCV NS5A protein claim 5 , and IMPDH for the treatment of an HCV infection.9. A method of treating an HCV infection in a patient claim 1 , comprising administering to the patient a therapeutically effective amount of a combination of claim 1 , or a pharmaceutically acceptable salt thereof.10. The method of further comprising administering one or two additional compounds having anti-HCV activity prior to claim 9 , after or simultaneously with the combination claim 9 , or a pharmaceutically acceptable salt thereof.11. The method of ...

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15-06-2011 дата публикации

Method for detecting components of flavor substance in milk

Номер: CN0102095818A
Принадлежит:

The invention discloses a method for detecting components of a flavor substance in milk, mainly comprising the following steps of: sampling a milk sample; placing the sample in a bottle; adding with NaCl, sufficiently and uniformly shaking so as to saturate the sample; sealing the bottle by a cover; purging top part volatile flavor substance by an automatic purge and trap concentrator; adsorbing the volatile flavor substance into a capillary trap which is filled with Tenax adsorbing material; stirring and heating the sample; introducing helium gas in the sample; and finally performing thermal analysis to analyze the volatile flavor substance, and automatically assaying by starting gas chromatograph-mass spectrometer (GC-MS) collecting data. The detecting method is a quick qualitative assaying method which is convenient, fast, excellent in reproducibility, short in using time and the like.

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10-11-1999 дата публикации

Capsule for treatment of rheumatic angitis and its preparation method

Номер: CN0001234271A
Автор: GAO MIN, MIN GAO
Принадлежит:

The Chinese medicine Fengshi Maiguan capsule for curing the diseases of angitis, rheumatic arthritis, rheumatoid arthritis, scapulohumeral periarthritis, sciatica and gout, etc. with high effective rate of above 90% is made up by using the Chinese medicinal materials of earthworm 10-20 portions, kadsura pepper stem 10-15 portions, cinnamon bark 10-15 portions, frankincense 20-30 portions, wingless cockroach 30-50 portions and leech 30-35 portions through the process of mixing, soaking them in 5-10 times solution formed from white liquor containing 30-50 per cent alcohol and edible rice vinegar for 6-7 days and drying to obtain dry medicinal material and capsulated it. Said invented Chinese medicine has a little toxic side effect and convenient for taking.

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11-09-2018 дата публикации

aplicações de produto de proteína adesiva de mexilhão no tratamento e prevenção de doenças relacionadas à melanina

Номер: BR112018000955A2

são reveladas aplicações de uma proteína adesiva de mexilhão ou preparações da mesma no tratamento e na prevenção de doenças relacionadas à melanina. são especialmente reveladas aplicações de uma proteína adesiva de mexilhão ou preparações da mesma no tratamento e na prevenção de pigmentações, tais como cloasma, sardas, melanose, aplicações em cânceres de pele, representados por melanoma, e aplicações no tratamento de pigmentação possivelmente causada por doenças de pele ou fármacos. applications of a mussel adhesive protein or preparations thereof are revealed in the treatment and prevention of melanin-related diseases. applications of a mussel adhesive protein or preparations thereof in the treatment and prevention of pigmentations, such as chloasma, freckles, melanosis, applications in skin cancers, represented by melanoma, and applications in the treatment of pigmentation possibly caused by diseases are especially revealed skin or drugs.

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15-09-2010 дата публикации

Float clearing boat

Номер: CN0101830273A
Принадлежит:

The invention discloses a float clearing boat, which comprises a boat body. The front end of the boat body is hinged with a transmission device and an oscillating oil cylinder; the transmission device comprises a rack, a transmission roll and a synchronous belt; the transmission roll is rotationally supported on the rack, the synchronous belt is in transmission fit with the transmission roll, andthe rack is hinged with the oscillating oil cylinder; the rack of the transmission device is also fixedly connected with a collecting bracket, and the collecting bracket is fixedly connected with a motor and rotationally connected with a collecting roller; the motor is in transmission connection with the collecting roller, and the collecting roller is positioned in front of the rack; at least oneside of the boat body is provided with a collecting rake; and the boat body under the tail end of the transmission device is also provided with a pressing device. The float clearing boat has the advantages ...

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01-02-2012 дата публикации

Vacuum adsorption type precision sowing device for plug tray seedlings

Номер: CN0202127601U

A vacuum adsorption type precision sowing device for plug tray seedlings comprises a horizontal central shaft (2), a roller (4) provided with an end cover (12) and a roller cover (3) and sleeved on the central shaft, a chain wheel (1) sleeved on the central shaft and positioned on the outer side of the roller cover, a seed chamber (11) arranged above one side of the roller and connected with the roller in a leaning manner, and a scraper (10) which is capable of axially scraping along the roller and arranged at the bottom end of the roller; axial vacuum cavities (6) are arranged along the circumference of the roller wall of the roller in a uniformly distributed manner; a group of suction holes running to the roller wall from the vacuum cavities along the radial direction are uniformly distributed along the length direction of each vacuum cavity; a seed suction nozzle (5) is arranged in each suction hole; a transitional cavity (9) which is running through and in butt joint with the vacuum ...

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27-01-1999 дата публикации

Mild catalytic fluorochloro ether dechlorinating process

Номер: CN0001205998A
Принадлежит:

The present invention is the mild dechlorinating process of fluorochloro ether in the organic solvent containing 1-10 vol% water and in the presence of zero-valence complex of transition metal and zinc. The process takes place at the temperature from RT to 80 deg.c for 0.5-10 hr reaction, and during the reaction the halide of mono-valent metal produces promoting effect. The process is simple and suitable for industrial production.

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25-05-2011 дата публикации

Method and device for dynamic monitoring and resource allocation

Номер: CN0101616420B
Автор: GAO MIN, MIN GAO
Принадлежит:

The invention discloses a method and a device for dynamic monitoring and resource allocation. A wireless access point (AP) carries out real-time monitoring and analysis on a frequency band resource in the wireless data receiving and sending process and obtains monitoring and analyzing content; according to the monitoring and analyzing content, frequency band resource allocation is performed in the wireless data receiving and sending process. The invention also discloses a device for dynamic monitoring and resource allocation. Under the condition of continuing the current service, the invention can dynamically switch to a clean channel to ensure the normal operation of service; the invention also can automatically switch to an operation mode of dual frequency band in clean environment, which improves transmission quality and avoids resource idleness.

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25-11-2009 дата публикации

Method for inhibiting background of deep space X-ray detection spectrometer

Номер: CN0101587191A
Принадлежит:

The invention provides a background inhibiting method applied to a deep space X-ray detection spectrometer, and relates to anti-radiation technology of deep space detection. The method comprises the following steps: (A) using a collimator with distribution of an intensity magnetic field to reduce radiation background; (B) using an amplitude analysis anti-coincidence method to alleviate the noise pollution and reduce the counting rate; and (C) applying multi-channel isolation technology to close a high-noise signal channel and reduce the total noise of the spectrometer. The method comprehensively utilizes the collimator with the magnetic field to shield background particles and utilizes the amplitude analysis anti-coincidence and the multi-channel isolation technology to inhibit the background of the spectrometer.

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07-09-2011 дата публикации

Rhizopus oryzae strain, mutagenic screening method thereof and method for producing fumaric acid through fermentation

Номер: CN0102174419A
Принадлежит:

The invention relates to a rhizopus oryzae strain, a mutagenic screening method thereof and a method for producing fumaric acid through fermentation. The strain has a classification name of rhizopus oryzae ME-F13, is preserved in the China Center for Type Culture Collection and has a preserving number of CCTCC M2010351. A method for obtaining the strain comprises the following steps of: processing an original strain ME-F12 by adopting ion implantation physical mutagenesis; then coating the processed bacterial solution on a selective solid flat plate containing 2-D-deoxyglucose (2-DG) for culture; and selecting an anti-2-DG single colony to synchronously saccharify a starch bearing material to prepare the fumaric acid through fermentation. The activity of a strain saccharifying enzyme screened by using the method is improved, and under the condition that the starch bearing material is not required to be saccharified, the strain saccharifying enzyme can be directly used for fermentation, ...

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20-08-2008 дата публикации

Isomerism fabric sorting device

Номер: CN0101246128A
Принадлежит:

The present invention relates to a foreign fiber sorting device which comprises a white foreign fiber sorting component and a colored foreign fiber sorting component that are arranged in a same box body. The invention overcomes the disadvantages of interference between the ultraviolet light and the visible light, large volume of the device, low sorting accuracy, high production cost and the like in the existing technique, and has the advantages of effectively insulating the ultraviolet light and visible light, high sorting accuracy, compact confirmation, low cost and the like.

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18-05-2011 дата публикации

Two-dimensional laser autocollimator

Номер: CN0101691998B
Принадлежит:

The invention relates to a two-dimensional laser autocollimator. The autocollimator comprises a generation device of left-hand and right-hand circular polarized light with reticule information on a horizontal optical axis, as well as a first common beam splitter prism, a collimating object lens and a target reflector which are sequentially arranged in the horizontal optical axis direction and theadvance direction of a 'cross' light beam, wherein the generation device generates the left-hand and right-hand circular polarized light with the reticule information to form centrosymmetric 'cross' light beam output; the beam-splitting plane of the first common beam splitter prism is in a 45-degree included angle with the horizontal optical axis; a first lambda/4 wave plate, a first polarizationsplitting prism and a horizontal linear array CCD are sequentially arranged on one side of the first common beam splitter prism; and a vertical linear array CCD is arranged in the reflected light direction ...

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07-06-2000 дата публикации

Process for preparing fruit-ginkgo leaf wine

Номер: CN0001255538A
Принадлежит:

A fruit-ginkgo leaf wine is made up of fruit (60-80 wt.%), gingko leaf (5-20 wt.%), white sugar (10-20 wt.%) and yeast (0.5-1.5 wt.%) through selecting raw materials, proportioning, crushing, fermenting, distillating, ageing, mingling and bottling. Its advantages are the characteristics of spirit, smell of fruit, and active components of ginkgo leaf.

Подробнее
11-11-2009 дата публикации

Method for deep space X fluorescence analysis

Номер: CN0101576517A
Принадлежит:

The invention discloses a method for deep-space X fluorescence analysis, which relates to X fluorescence analysis technology and uses simulative standard sample for quantitative analysis of fluorescent data of deep space planets when no actual standard sample is available. Combining with a Monte CarLo method and a fundamental parameter method, the method comprises the following steps: using x-rays, measured by a solar monitor, radiated from the sun at different times as an excitation energy spectra; adopting a geant2 software package to simulate the fluorescence spectra of different samples by using the Monte CarLo method; performing the iterative computation of fluorescence energy spectra measured in orbit and a standard energy spectrum obtained by simulation by using programs complied on the basis of the fundamental parameter method; and meshing data according to ephemeris data and field coverage design of a probe to obtain the distribution data of elements of the planets. The method ...

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24-08-2011 дата публикации

Method for installing and hoisting gas-insulated metal closed power transmission line in shaft and device thereof

Номер: CN0101552430B
Принадлежит:

The invention relates to the field of large and medium hydropower projects, in particular to a method for installing and hoisting gas-insulated metal closed power transmission line in a shaft, and a device thereof. The method is characterized in that the installation of the gas-insulated metal closed power transmission line GIL device (4) adopts two independent procedures by using a hoisting device with large hoisting height, namely, preassembly procedure and final installation procedure to carry out installation and hoisting. The method has the advantages of simple structure, safety, reliability and obvious effect and has great popularization and application values in solving the technical problems of hoisting the GIL device in a highly vertical shaft safely, fastening the installation ofthe GIL device, arranging equipment and the like.

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25-03-2009 дата публикации

Alkylation reaction method of benzimidazoles compounds

Номер: CN0101391982A
Принадлежит:

The invention aims at providing a simple, convenient and economic benzimidazole compound alkylation method, which has the following concrete processes: corresponding benzimidazole, alkyl halide and quaternary ammonium salt are put into a reaction flask and heated to 35 to 100 DEG C for reaction for 3 to 8 hours until the benzimidazole raw material is completely reacted, and then the expected intermediate products are obtained by separation and purification. The benzimidazole alkylation method provided by the invention has the advantages of simple operation, easy separation, high yield, small toxicity, environmental protection and being suitable for industrial production.

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27-04-2011 дата публикации

Remote batch update method orientating large-scale wireless sensor network node program

Номер: CN0102035887A
Принадлежит:

The invention discloses a remote batch update method orientating a large-scale wireless sensor network node program. In the invention, large-scale wireless sensor network nodes are connected with different adapter plates according to different interface modes and then uniformly connected with a control processing gateway named as SnapGate through a USB (Universal Serial Bus) port to form a distributed framework; a central control server is used for realizing the remote batch update of the network nodes and resetting nodes during a network failure; the central control server establishes a mapping relation between program update interface nodes and real sensor nodes according to a unique identification carried by each sensor node; the sensor nodes are divided according to the SnapGates of different IP (Internet Protocol) addresses so as to establish a program update list of the sensor nodes; and the identifications of the nodes to be updated, node IDs preset by a user and a control command ...

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14-09-2011 дата публикации

Pineapple peeling device

Номер: CN0102178441A
Принадлежит:

The invention belongs to the technical field of articles for daily use, and in particular relates to a pineapple peeling device. The device comprises a body (1), and a fixing mechanism (2), a cutting mechanism (3) and an actuating unit (4) are arranged on the body (1). The device is characterized in that the cutting mechanism (3) is fixed with the actuating unit (4), the fixing mechanism (2) is arranged just below the cutting mechanism (3), the cutting mechanism (3) comprises 2-8 blades (31), the blades (31) are arranged in a circle, and every two adjacent blades (31) are connected by virtue of a spring (32). The pineapple peeling device has the advantages of simple structure, convenience during application and low manufacturing cost and has a better market prospect.

Подробнее
11-11-2009 дата публикации

Household palmtop mobile television system

Номер: CN0101577650A
Принадлежит:

The invention relates to a household palmtop mobile television system and relates to the field of computer streaming media. The household palmtop mobile television system combines the mobility of mobile phones and the entertainment of televisions and expands household entertainment modes. A server (3) receives the input of two television signals (1 and 2) and responds to control commands sent by the mobile phone (7), wherein one signal is sent to a television (6), and the other signal is sent to an intelligent mobile phone (7) by wireless networks (4 and 5) to play. The system has clear structure, is easy to expand; and the streaming media are real-time and easy to control so that household users can obtain new entertainment experiences on a wireless mobile platform at any corner.

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24-12-2008 дата публикации

Intelligent network business implementing system and method for preventing user identification from being stolen

Номер: CN0101330756A
Принадлежит:

The invention relates to an intelligent network service realization system and a method for preventing user identity from being embezzled. The realization method comprises the following steps: a calling service MSC/SSP is increased in the normal process of the intelligent network service to report an IMEI number to a user; when the IMEI number reported by the user is different from an IMEI number preserved in a calling home area SCP, the calling home area SCP informs the calling service IP that the user is prompted to enter a service password; the calling home area SCP determines whether to continue the calling according to the consistency between a judgment service password and a saved service password. The invention provides an intelligent network service for enhancing the legal identity of a protected user; on the premise of changing an original authentication system, an IMSI is incident on the IMEI; furthermore, the simultaneous confirmation of a unit and a card is ensured when the ...

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24-11-2010 дата публикации

Method for detecting safety of welding seam of geomembrane by using negative pressure

Номер: CN0101893501A
Принадлежит:

The invention relates to a method for detecting sealing property of a squeezed single-track welding seam of a polyethylene geomembrane. The method comprises the following steps of: (1) coating a surfactant on a detection region; (2) reducing the pressure at the detection region to 25-35kPa; and (3) judging whether bubbles occur at the detection region in 10 seconds, wherein if bubbles do not occur, the sealing property of the detection region is qualified, and if the bubbles occur, the sealing property of the detection region is not qualified. The method has the advantages of convenience and simplicity, low detection cost, easy popularization and capability of detecting any part of the polyethylene geomembrane at any time.

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24-02-2010 дата публикации

T/2 fraction spaced blind equalization method (T/2-FSE-WNN) introducing small wave neural network

Номер: CN0101656579A
Принадлежит:

The invention discloses a T/2 fraction spaced blind equalization method (T/2-FSE-WNN) introducing a small wave neural network. In the method, the small wave neural network is merged into the T/12 fraction spaced blind equalization method by utilizing higher approaching capability of the small wave neural network and the advantage that the fraction space has over sampling for a blind equalizer receiving signal on the basis of analyzing the small wave neural network and the fraction space theory. Compared with a T/2 fraction spaced feed forward neural network blind equalization method (T/2-FSE-FNN) and a small wave neural network blind equalization method (WNN), the T/2 fraction spaced blind equalization method (T/2-FSE-WNN) has higher convergence speed, smaller steady state error and mean square root error and carrier wave recovery property, and a water sound channel simulation result ventilates the effectiveness of the T/2 fraction spaced blind equalization method (T/2-FSE-WNN).

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24-02-2010 дата публикации

Project progress tracking system and method thereof

Номер: CN0101655932A
Принадлежит:

A project progress tracking system comprises a project data deciphering module, a project state timetable operation module, a document searching module, a mail sending module and a tracking state recording module, the project data deciphering module deciphers target project to generate project state timetable; the project state timetable operation module reads the project state timetable and executes operations such as modification and delete, to estimate to search document or send conference mail notice through the timetable; the document searching module searches whether matured document tobe submitted is existed in the configuration management database to estimate to update the project state timetable or prompt reception of the sent main; the mail sending module is used to send mails to mail boxes of related persons; the tracking state recording module is used for recording tracking state in the operation process of the system. The invention may simultaneously process a plurality of ...

Подробнее
14-03-1990 дата публикации

PROTEIN REAGENT FOR RAPID DETECTION OF C-REACTION

Номер: CN0001040438A
Принадлежит:

Подробнее
28-11-2007 дата публикации

AC position servo system interference observation and compensation method

Номер: CN0101078910A
Принадлежит:

The invention discloses an observing and compensating method of disturbance in three-phase asynchronous motor complexor controlling slave system, which is characterized by the following: combining disturbance observer (DOB) and PID controlling method; inhibiting disturbance in the system; adopting di-closed-loop structure of position loop and electric current loop for slave system; designing disturbance observer (DOB) in the position loop faced to electric current loop; adopting PI to control for the electric current loop; adopting PD to control for the position loop. This invention possesses simple realization, simple method and easy control, which disturbance observer (DOB) possesses the advantages of quick response and separate adjustment.

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17-02-2010 дата публикации

Blind equalization method for wavelet neural network based on space diversity

Номер: CN0101651643A
Принадлежит:

The invention discloses a blind equalization method for a wavelet neural network based on space diversity. On the basis of analysis of a space diversity technology and the equalization performance of a wavelet neural network, the method reduces the influence of fading by utilizing the space diversity and overcomes intersymobl interferences by using the stronger approximation capacity of a blind equalizer of the wavelet neural network. The invention overcomes the intersymobl interferences caused by the multipath propagation and the fading characteristic of a channel at a receiving end, improves the communication quality and has high convergence speed and small mean square error. The effectiveness of the method is verified by an acoustic channel simulation result. The method can effectivelyrealize the separation of signals and noise and the real-time restoration of the signals.

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12-02-1992 дата публикации

HIGH-SPEED HIGH-ACCURACY A-D CONVERTER

Номер: CN0001058678A
Автор: MIN GAO, GAO MIN
Принадлежит:

The high-speed high-accuracy A-D converter is a secondary conversion type A-D converter. It adopts a parallel circuit structure so as to realize the parallel execution of inside sub-process of A-D conversion. As compared with normal secondary conversion type high-accuracy A-D converter, it has an important improvement and obviously increases conversion speed. The high-speed high-accuracy A-D converter can be made either of existing IC devices to realize on circuit board, or into hybrid IC devices or single-chip IC device.

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17-11-2020 дата публикации

fabric bias for teeth and toothed power transmission belt

Номер: BR112020011624A2
Принадлежит:

Подробнее
18-03-2009 дата публикации

Intelligent low constant pressure wound drainage system

Номер: CN0101385887A
Автор: GAO MIN, MIN GAO
Принадлежит:

The invention discloses a smart low constant-pressure wound drainage system, which aims at providing a wound drainage system which can detect the actual negative pressure value and control a negative pressure pump to adjust the pressure during the drainage, so as to realize a scientific drainage treatment and reduce the labor intensity of the nursing staff. A pressure sensor is connected with a liquid tank; the pressure sensor is also connected with a control signal input terminal of a main drainage controller by an A/D converter; the control signal output terminal of the main drainage controller is connected with that of an AC voltage regulator by a D/A converter; the control signal output terminal of the AC voltage regulator is connected with a negative pressure pump which is connected with the liquid tank, and the main drainage controller is connected with a data inputting device. The smart low constant-pressure wound drainage system can detect the actual negative pressure value in the ...

Подробнее
24-06-1992 дата публикации

PROTEIN REAGENT FOR RAPID DETECTION OF C-REACTION

Номер: CN0001017190B
Принадлежит: QUNJUN DU, DU QUNJUN

Подробнее
03-06-2009 дата публикации

Resource management system based on net system business structure platform

Номер: CN0101446897A
Принадлежит:

A resource management system based on a business structure platform relates to the technical field of computers. The invention is characterized in that a business based hierarchical system platform is established on a net system; a resource access control platform is set up on the basis of business according to the hierarchy; according to access set by an organization mechanism, the resource access control management platform exercises control over resources; an ETL tool and a CUB tool are adopted for setting up a database warehouse; each data connected is controlled and dispatched by a data source adapter; data connections between all databases and all logical databases are established separately; according to the characteristics of all data sources, a logical database adapter sets up a logical data sheet; and according to the logical data sheet, mapping of each data resource in each database is set up. The invention establishes the hierarchical structure platform according to business ...

Подробнее
05-11-2008 дата публикации

Nano material optical characterization method and system based on optical fiber and nano-controller

Номер: CN0101299024A
Принадлежит:

The present invention discloses a nano material optical charcterization method based on optical fiber and nano manipulator and a system thereof, belonging to the filed of nano material optical characterization and nano optoelectronic device test. The method of the invention is a method for introducing the radiated light of the nano material from the radiation area to the optical analysis device or introducing the radiated light of the light source to the area of nano material through the combination of the probe of the optical fiber and the nano manipulator. The system of the invention comprises a microscope, an optical analyzer and/or a light source, a nano manipulator, a probe of optical fiber, a sample table and/or a probe. The method of the invention has a capability for discriminating angle. The system executes optical excitation or optical analysis to the selected mini-area. The accommodation area is small and a larger flexibility is provided. At the same time the system can be combined ...

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23-04-2014 дата публикации

Device and method for quick evaluation of performance of electroplating method for micropore filling

Номер: CN103743798A
Принадлежит:

The invention provides an electrochemical analyzing device and a method for quick evaluation of performance of electroplating method for micropore filling. The electrochemical analyzing device includes an electric power producing device, an electric output signal measuring device, an electrochemical measuring device and a movement generator. The electrochemical measuring device includes a support structure, an empty cavity, a cavity electrode and a surface electrode. Electric output signals of the measuring cavity electrode and the surface electrode are measured for calculating filling performance value in an electroplating period. The invention provides an accurate, quick and cost-efficient method used for evaluating performing of the electroplating method, so that the electroplating method with the highest filling performance value can be chosen for being applied to the practical micropore filling process.

Подробнее
26-12-2001 дата публикации

Capsule for treatment of rheumatic angitis and its preparation method

Номер: CN0001076621C
Автор: GAO MIN, MIN GAO
Принадлежит:

Подробнее
11-03-2009 дата публикации

Modified asphalt and preparation method thereof

Номер: CN0101381520A
Принадлежит:

The invention provides modified asphalt and a preparation method thereof. The composition of the modified asphalt in mass percentage comprises 90 to 99 percent of base asphalt, 1 to 10 percent of nanometer powder styrene butadiene polymer and 0 to 5 percent of terpene resin. The preparation method comprises the following steps of heating, melting and adding the terpene resin to the asphalt at a temperature between 160 and 200 DEG C, adding the nanometer powder styrene butadiene polymer and stirring for more than 2 hours at the same temperature, or grinding the terpene resin into powder, adding the terpene resin powder together with the nanometer powder styrene butadiene polymer to the asphalt at a temperature between 160 and 200 DEG C and fully stirring for more than 2 hours. The invention has the advantages that the preparation method directly adopts the nanometer powder styrene butadiene polymer which is easy to uniformly distribute in an asphalt system and good in system compatibility ...

Подробнее
17-06-2009 дата публикации

AC position servo system interference observation and compensation method

Номер: CN0100501606C
Принадлежит:

Подробнее
05-11-2008 дата публикации

Medical use of iso-papaverine

Номер: CN0101297804A
Принадлежит:

The invention relates to a usage of an iso-papaverine in the medicine, in particular to the usage of the iso-papaverine in the preparation of analgesic drugs with the analgesic efficacies. The usage of using the iso-papaverine in the preparation of the medicaments is characterized in that: the medicaments have significant inhibition effects on central and peripheral pains, and have certain anti-inflammatory and immune effects, thus having special efficacies for alleviating pain; furthermore, the toxicity of the medicaments is very small, and the side effect is also small. Compared with the existing clinical commonly used analgesic drugs, the iso-papaverine has different chemical structure, determined analgesic effect, stronger analgesic effect and no addiction.

Подробнее
15-06-2011 дата публикации

Method for detecting fruity substance in fruit flavoring agent

Номер: CN0102095820A
Принадлежит:

The invention discloses a method for detecting a fruity substance component in a fruit flavoring agent. The method mainly comprises the following steps of: aging an extraction fiber head polydimethylsiloxane (PDMS) of solid-phase micro-extraction (SPME) at a sample inlet of a gas chromatography; dissolving the fruit flavoring agent in a bottle; adding NaCl, and fully and uniformly shaking until the solution is saturated; covering and sealing; preheating a sample in water; inserting the aged PDMS fiber extraction head into the headspace part of a sample bottle; pushing the extraction head out; performing extraction on the headspace part of the sample bottle under the action of a magnetic stirrer; retracting the fiber head; quickly inserting the fiber head into the sample inlet of the gas chromatography; safely and quickly pushing the fiber head out; performing thermal analysis on absorbed aroma components; and starting a gas chromatography-mass spectrometry (GC-MS) instrument to acquire ...

Подробнее
14-10-2009 дата публикации

V-ribbed belt and method for manufacturing same

Номер: CN0101558251A
Принадлежит:

A V-ribbed belt that includes a ribbed surface covered with fabric is provided. The fabric is stretchable in two predetermined directions. A method for manufacturing the V- ribbed belt is also provided. The method includes placing a belt matrix about a mandrel, placing a fabric about the external circumference of the belt matrix which wraps around the mandrel, placing the mandrel inside a shell having a plurality of grooves on the internal circumference, expanding the belt matrix and the fabric toward the internal circumference of the shell and thus pressing the fabric onto the internal circumference having the multi-ribbed structure, and curing the belt matrix with the fabric. The fabric is stretchable to accommodate itself to the multi-ribbed structure.

Подробнее
11-11-2009 дата публикации

Indoor positioning system based on RFID technology

Номер: CN0101576616A
Принадлежит:

The invention provides a new indoor accurate positioning system based on a RFID technology. The system is shown in a figure 1 and mainly comprises components, such as RFID reader-writers, RFID reference tags, RFID track tags, and the like, and a user can obtain corresponding positioning service by connecting a personal intelligent device to a wireless local area network. The system uses wireless signal intensity as a positioning reference, the tags are communicated with the reader-writers by radio waves, and each reader-writer can read and record the signal intensity of all tags at set intervals. A certain reference tags at known positions are used as reference points, and the signal intensity of the track tags are compared with the signal intensity of the reference tags by the positioning method according to the signal intensity characteristics of the reference points so as to obtain more accurate position information of the track tags.

Подробнее
18-04-2012 дата публикации

Resource management system based on net system business structure platform

Номер: CN0101446897B
Принадлежит:

A resource management system based on a business structure platform relates to the technical field of computers. The invention is characterized in that a business based hierarchical system platform is established on a net system; a resource access control platform is set up on the basis of business according to the hierarchy; according to access set by an organization mechanism, the resource access control management platform exercises control over resources; an ETL tool and a CUB tool are adopted for setting up a database warehouse; each data connected is controlled and dispatched by a data source adapter; data connections between all databases and all logical databases are established separately; according to the characteristics of all data sources, a logical database adapter sets up a logical data sheet; and according to the logical data sheet, mapping of each data resource in each database is set up. The invention establishes the hierarchical structure platform according to business ...

Подробнее
15-12-2010 дата публикации

Method for detecting safety of welding line of geomembrane by using positive pressure

Номер: CN0101915644A
Принадлежит:

The invention relates to a method for detecting the airtightness of a hot-melt double-track welding line of polyethylene geomembrane. The method comprises the following steps of: (1) making the upper and lower films of a detected area form a cavity; (2) inserting a pinhead connected with an inflation device into the cavity and inflating until the air pressure in the cavity reaches 250kPa; (3) judging the change of the air pressure in the cavity within 3 to 5 minutes, if the air pressure does not drop or is no lower than 240kPa, indicating that the airtightness of the welding line of the detected area is qualified, and if the air pressure drops to lower than 240kPa, indicating that the airtightness of the welding line of the detected area is unqualified; and (4) pulling the pinhead out to exhaust air and closing a pinhole. The detection method can effectively and quickly detect the airtightness of the hot-melt double-track welding line of the polyethylene geomembrane.

Подробнее
29-05-2002 дата публикации

Equipment for brewing fruit spirit

Номер: CN0001085727C
Принадлежит:

Подробнее
06-04-2011 дата публикации

Compound preparation for treating depression

Номер: CN0102000334A
Принадлежит:

The invention discloses a compound preparation for treating depression with the traditional antidepressant and curcumin as active components; the traditional antidepressant is a nonselective reuptake inhibitor or a selective 5-hydroxytryptamine reuptake inhibitor, wherein the nonselective reuptake inhibitor is desipramine, the selective 5-hydroxytryptamine reuptake inhibitor is fluoxetine, and the mass ratio of the traditional antidepressant to the curcumin can concretely be 2:1 or 4:1. In the compound preparation for treating the depression, low dosage curcumin and low dosage desipramine or fluoxetine are combined, thereby counteracting the adverse effects caused by blood sugar rise and displaying stronger antidepressant activity, and therefore, the compound preparation has good application prospect.

Подробнее
12-01-2005 дата публикации

Copper base catalyst in use for preparing hydrogen by reforming vapor of methanol and preparation method

Номер: CN0001562472A
Принадлежит:

A Cu-base catalyst for preparing hydrogen by water vapour reforming to methanol is composed of the active component (CuO/ZnO/Al2O3 and the silicon oxide-base mesoporous material. Its preparing process includes quantitatively adding mesoporous silicon oxide to reactor, simultaniously dropping the solution of nitrate and the solution of sodium carbonate in the reactor while stirring, depositing reaction, washing, drying and calcining. Its advantages are unique large surface area and porous structure, and high low-temp activity and selectivity.

Подробнее
14-07-2010 дата публикации

Isomerism fabric sorting device

Номер: CN0101246128B
Принадлежит:

The present invention relates to a foreign fiber sorting device which comprises a white foreign fiber sorting component and a colored foreign fiber sorting component that are arranged in a same box body. The invention overcomes the disadvantages of interference between the ultraviolet light and the visible light, large volume of the device, low sorting accuracy, high production cost and the like in the existing technique, and has the advantages of effectively insulating the ultraviolet light and visible light, high sorting accuracy, compact confirmation, low cost and the like.

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13-10-2020 дата публикации

monoclonal anti-trkb antibodies and methods of use

Номер: BR112020006976A2
Принадлежит: Regeneron Pharmaceuticals, Inc.

Anticorpos que se ligam especificamente a TrkB e métodos de uso dos mesmos são descritos. Os anticorpos agonistas que são neuroprotetores, tal como mostrado pelo seu efeito na melhora da sobrevivência de células ganglionares da retina in vitro são descritos e estes anticorpos agonistas podem ser usados em tratamentos tais como disfunções do olho, incluindo glaucoma. Além disso, outras doenças neuronais ou disfunções se beneficiam do tratamento com estes anticorpos agonistas, incluindo aqueles caracterizados, em parte, por dano neuronal. Em determinadas modalidades, a invenção inclui anticorpos que se ligam a TrkB e mediam a sinalização celular. Os anticorpos da invenção podem ser anticorpos completamente humanos, de ocorrência não natural formulados com excipientes para injeção. Antibodies that specifically bind to TrkB and methods of using them are described. Agonist antibodies that are neuroprotective, as shown by their effect in improving the survival of retinal ganglion cells in vitro are described and these agonist antibodies can be used in treatments such as eye disorders, including glaucoma. In addition, other neuronal diseases or dysfunctions benefit from treatment with these agonist antibodies, including those characterized, in part, by neuronal damage. In certain embodiments, the invention includes antibodies that bind to TrkB and mediate cell signaling. The antibodies of the invention can be completely human, non-naturally occurring antibodies formulated with excipients for injection.

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18-06-2015 дата публикации

Apparatus and Method for Fast Evaluation of Electroplating Formulation Performance in Microvia Filling

Номер: US20150167195A1

The presently claimed invention provides an electrochemical analytical apparatus and a method for evaluating performance of electroplating formulations of electrolyte solutions used for via filling. The electrochemical analytical apparatus comprises an electric power generating device, an electrical output signal measurement device, an electrochemical measurement device, and a motion generator. The electrochemical measurement device of the present invention comprises a supporting structure, a cavity, a cavity electrode, and a surface electrode. The electrical output signals of the cavity electrode and the surface electrode are measured during electroplating for calculating a filling performance value. The presently claimed invention provides an accurate, fast and cost effective method for evaluating performance of electroplating formulations, following with choosing the electroplating formulation of the highest FP value for actual microvia filling process. 1. An electrochemical measurement device for evaluating performance of an electroplating formulation of an electrolyte solution used for via filling , comprising:at least one supporting structure, comprising at least one measurement surface for contacting the electrolyte solution;at least one cavity, located at the supporting structure, and comprising a top cavity opening and a bottom cavity opening, wherein the top cavity opening is located on the measurement surface of the supporting structure, and allows the electrolyte solution to flow into the cavity;at least one cavity electrode, wherein the cavity electrode comprises at least one cavity electrolytic surface, which is in contact with the bottom cavity opening, and is used for being electroplated by the electrolyte solution; andat least one surface electrode, wherein the surface electrode comprises at least one top electrolytic surface, which is located on the measurement surface of the supporting structure, and is used for being electroplated by the ...

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15-06-2011 дата публикации

Culture substrate for industrial cultivation of agaricus bisporus

Номер: CN0102093106A
Принадлежит:

The invention discloses a culture substrate for industrial cultivation of agaricus bisporus, which belongs to the technical field of culturing of edible fungi. According to the technical scheme of the invention, the culture substrate for the industrial cultivation of agaricus bisporus is characterized by comprising following raw and auxiliary materials in part by weight: 72 to 156 parts of maize straw, 104 to 188 parts of wheat straw, 160 to 220 parts of chicken manure and 2 to 5 parts of gypsum. Compared with the prior art, the culture substrate has the advantages that: the raw material source of the culture substrate for the agaricus bisporus is widened, the raw materials can be obtained locally, the production costs of the raw materials are lowered, and the economic benefit of an agaricus bisporus production enterprise is enhanced; moreover, the culture substrate has a reasonable formula and reliable physical and chemical property indexes, is fully accordant with the growth requirement ...

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20-04-2011 дата публикации

Method and device for detecting abnormity of wireless terminal through wireless access point

Номер: CN0101583150B
Принадлежит:

The invention discloses a method and a device for detecting the abnormity of a wireless terminal through a wireless access point. The method includes the following steps: the wireless access point detects the failure rate of unicast messages sent to the wireless terminal in business process at real time and determines the wireless terminal as an abnormal user if the failure rate of unicast messages sent to the wireless terminal is detected to continuously exceed the predetermined upper limit in a period of time. The invention can not only accurately detect the abnormal situations, for example,caused by the reason that the wireless terminal exceeds the coverage range of wireless network, and the like, but also shorten detection time and take necessary steps in time. Therefore, the method and the device can avoid the blockage of a wireless channel caused by an abnormity, reduce the influence on other wireless users to the minimum degree and avoid faulty operation simultaneously.

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18-11-2009 дата публикации

Method and device for detecting abnormity of wireless terminal through wireless access point

Номер: CN0101583150A
Принадлежит:

The invention discloses a method and a device for detecting the abnormity of a wireless terminal through a wireless access point. The method includes the following steps: the wireless access point detects the failure rate of unicast messages sent to the wireless terminal in business process at real time and determines the wireless terminal as an abnormal user if the failure rate of unicast messages sent to the wireless terminal is detected to continuously exceed the predetermined upper limit in a period of time. The invention can not only accurately detect the abnormal situations, for example, caused by the reason that the wireless terminal exceeds the coverage range of wireless network, and the like, but also shorten detection time and take necessary steps in time. Therefore, the method and the device can avoid the blockage of a wireless channel caused by an abnormity, reduce the influence on other wireless users to the minimum degree and avoid faulty operation simultaneously.

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08-09-2010 дата публикации

Nano material optical characterization method and system based on optical fiber and nano-controller

Номер: CN0101299024B
Принадлежит:

The present invention discloses a nano material optical charcterization method based on optical fiber and nano manipulator and a system thereof, belonging to the filed of nano material optical characterization and nano optoelectronic device test. The method of the invention is a method for introducing the radiated light of the nano material from the radiation area to the optical analysis device or introducing the radiated light of the light source to the area of nano material through the combination of the probe of the optical fiber and the nano manipulator. The system of the invention comprises a microscope, an optical analyzer and/or a light source, a nano manipulator, a probe of optical fiber, a sample table and/or a probe. The method of the invention has a capability for discriminating angle. The system executes optical excitation or optical analysis to the selected mini-area. The accommodation area is small and a larger flexibility is provided. At the same time the system can be combined ...

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15-06-2011 дата публикации

Method for deep space X fluorescence analysis

Номер: CN0101576517B
Принадлежит:

The invention discloses a method for deep-space X fluorescence analysis, which relates to X fluorescence analysis technology and uses simulative standard sample for quantitative analysis of fluorescent data of deep space planets when no actual standard sample is available. Combining with a Monte CarLo method and a fundamental parameter method, the method comprises the following steps: using x-rays, measured by a solar monitor, radiated from the sun at different times as an excitation energy spectra; adopting a geant2 software package to simulate the fluorescence spectra of different samples byusing the Monte CarLo method; performing the iterative computation of fluorescence energy spectra measured in orbit and a standard energy spectrum obtained by simulation by using programs complied onthe basis of the fundamental parameter method; and meshing data according to ephemeris data and field coverage design of a probe to obtain the distribution data of elements of the planets. The methodof ...

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06-08-2008 дата публикации

A differential network service method and system based on user subscription information

Номер: CN0101237702A
Принадлежит:

The invention relates to a method and a system of differentiated network service based on subscriber subscription information, wherein the method comprises the following steps: subscriber subscription information is stored in a home location register (HLR); a calling MSC maps the subscription information of a calling subscriber to the wireless channel allocated requirement of the calling subscriber; moreover, the wireless channel allocated requirement is force, queuing and force, force and forced releasing, or queuing, force and forced releasing; the calling MSC sends the wireless channel allocated requirement to a calling BSS; according to the condition of service of the current wireless resource and the wireless channel allocated requirement of the calling subscriber, the calling BSS completes resource allocation and sends the result of resource allocation to the calling MSC; if the calling BSS completes successful resource allocation, the calling MSC is connected with a called subscriber ...

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02-08-2012 дата публикации

Combinations of Hepatitis C Virus Inhibitors

Номер: US20120196794A1
Принадлежит: Bristol Myers Squibb Co

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit Hepatitis C virus (HCV), compositions comprising such compounds, and methods for treating hepatitis C using such combinations.

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20-06-2013 дата публикации

METHODS TO IDENTIFY COMBINATIONS OF NS5A TARGETING COMPOUND THAT ACT SYNERGISTICALLY TO INHIBIT HEPATITIS C VIRUS REPLICATION

Номер: US20130157894A1
Принадлежит:

The present invention is based on the surprising finding that pairs of HCV NS5A-targeting inhibitors can be identified which display similar resistance profiles yet, when combined, exhibit synergistic inhibition of wild type replicons and/or replicons carrying mutations conferring resistance to the HCV NS5A-targeting inhibitor. In addition, combinations of these molecules result in a higher genetic barrier to resistance, demonstrating their potential utility as novel combination therapies for treatment of HCV. 1. A method for identifying NS5A-targeting compounds that in combinations demonstrate a synergistic inhibitory interaction toward wild-type and/or variants that reduce the potency of the NS5A-targeting inhibitors alone comprising the steps of:(a) screening a compound library for NS5A targeting compounds and(b) comparing the amount of HCV inhibition of a NS5A-targeting inhibitor in the presence and absence of a fixed concentration of a NS5A-targeting compound andwherein the second NS5A-targeting compound may or may not demonstrate HCV NS5A inhibitory activity when assayed alone and wherein the combination of the NS5A-targeting compounds demonstrate a synergistic inhibition of HCV replicon or virus replication.2. The method of wherein the compound library is screened in cells containing a HCV sequence derived from any genotype.3. The method of wherein the HCV inhibitory activity is determined by using a cell-based method or a biochemical surrogate.4. The method of wherein the HCV sequence is selected from the group consisting of wild-type or sequences carrying NS5A resistant variants.5. The method of wherein said HCV sequence is genotype 1b carrying a Y93H single amino acid substitution in NS5A.6. The method of wherein said HCV sequence is genotype 1b carrying a L31V single amino acid substitution in NS5A.7. The method of wherein said HCV sequence is genotype 1a carrying a M28T single amino acid substitution in NS5A.8. The method of wherein said HCV sequence is ...

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18-07-2013 дата публикации

Hepatitis C Virus Inhibitors

Номер: US20130183269A1
Принадлежит: BRISTOL-MYERS SQUIBB COMPANY

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein. 1. A combination comprising an NS5A-targeting compound and an NS5A synergist , which , when administered , provides synergistic anti-HCV activity against variants that contain mutation(s) conferring resistance to the NS5A-targeting compound alone.2. The combination of which comprises two or more pharmaceutically acceptable carriers.3. The combination of wherein the NS5A-targeting compound and the NS5A synergist are combined in the same pharmaceutically acceptable carrier.19. A composition comprising a combination of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , and a pharmaceutically acceptable carrier.20. The composition of further comprising one or two additional compounds having anti-HCV activity.21. The composition of wherein at least one of the additional compounds is an interferon or a ribavirin.22. The composition of wherein the interferon is selected from interferon alpha 2B claim 21 , pegylated interferon alpha claim 21 , pegylated interferon lambda claim 21 , consensus interferon claim 21 , interferon alpha 2A claim 21 , and lymphoblastoid interferon tau.23. The composition of wherein at least one of the additional compounds is effective to inhibit the function of a target selected from HCV protease claim 20 , HCV polymerase claim 20 , HCV helicase claim 20 , HCV NS4B protein claim 20 , HCV entry claim 20 , HCV assembly claim 20 , HCV egress claim 20 , HCV NS5A protein claim 20 , and IMPDH for the treatment of an HCV infection.24. A method of treating an HCV infection in a patient claim 1 , comprising administering to the patient a therapeutically effective amount of a combination of claim 1 , or a pharmaceutically ...

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01-08-2013 дата публикации

Anti-asic1 antibodies and uses thereof

Номер: US20130195878A1
Принадлежит: Regeneron Pharmaceuticals Inc

The present invention provides antibodies and antigen-binding fragments thereof that specifically bind to cells expressing acid-sensing ion channel-1 (ASIC1). According to certain embodiments of the invention, the antibodies inhibit acid-induced, ASIC1-mediated ion currents in cells expressing human ASIC1. The antibodies of the invention are useful for the treatment of pain, including pain associated with surgical intervention and various diseases and disorders.

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03-10-2013 дата публикации

Combinations of Hepatitis C Virus Inhibitors

Номер: US20130259832A1
Принадлежит:

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit Hepatitis C virus (HCV), compositions comprising such compounds, and methods for treating Hepatitis C using such combinations. 2. The composition of further comprising one or two additional compounds having anti-HCV activity.3. The composition of wherein at least one of the additional compounds is an interferon or a ribavirin.4. The composition of wherein the interferon is selected from interferon alpha 2B claim 3 , pegylated interferon alpha claim 3 , consensus interferon claim 3 , interferon alpha 2A claim 3 , interferon lambda claim 3 , pegylated interferon lambda claim 3 , and lymphoblastoid interferon tau.5. A method of treating an HCV infection in a patient claim 1 , comprising administering to the patient a therapeutically effective amount of a composition of .6. The method of further comprising administering one or two additional compound having anti-HCV activity prior to claim 1 , after or simultaneously with the composition of .7. The method of wherein at least one of the additional compounds is an interferon or a ribavirin.8. The method of wherein the interferon is selected from interferon alpha 2B claim 7 , pegylated interferon alpha claim 7 , consensus interferon claim 7 , interferon alpha 2A claim 7 , interferon lambda claim 7 , pegylated interferon lambda claim 7 , and lymphoblastoid interferon tau. This continuation application claims the benefit of U.S. Ser. No. 12/899,840 filed Oct. 7, 2010, now allowed, which in turn claims the benefit of U.S. Provisional Application U.S. Ser. No. 61/250,648 filed Oct. 12, 2009.The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit Hepatitis C virus (HCV), compositions comprising such compounds, and methods for treating Hepatitis C using such combinations.HCV is a major human ...

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27-02-2014 дата публикации

ANTI-ASIC1 ANTIBODIES AND USES THEREOF

Номер: US20140056907A1
Принадлежит: Regeneron Pharmaceuticals, Inc.

The present invention provides antibodies and antigen-binding fragments thereof that specifically bind to cells expressing acid-sensing ion channel-1 (ASIC1). According to certain embodiments of the invention, the antibodies inhibit acid-induced, ASIC1-mediated ion currents in cells expressing human ASIC1. According to certain embodiments, the antibodies of the invention are selective for ASIC1 and do not bind other acid-sensing ion channels in the absence of ASIC1. The antibodies of the invention are useful for the treatment of pain, including pain associated with surgical intervention and various diseases and disorders. 1. An isolated antibody or antigen-binding fragment thereof that specifically binds cells expressing ASIC1 (SEQ ID NO:401) , wherein the antibody or antigen-binding fragment thereof does not bind cells expressing other acid-sensing ion channels (ASIC2 , ASIC3 or ASIC4) in the absence of ASIC1.2. The antibody or antigen-binding fragment of claim 1 , wherein the antibody or antigen-binding fragment thereof binds cells expressing ASIC1 homomultimers or ASIC1/ASIC3 heteromultimers claim 1 , and wherein the antibody or antigen-binding fragment thereof does not bind cells expressing ASIC3 homomultimers.3. The antibody or antigen-binding fragment of claim 2 , wherein the antibody or antigen-binding fragment thereof inhibits acid-induced ion currents in cells expressing ASIC1 claim 2 , but does not inhibit acid-induced ion currents in cells expressing other acid-sensing ion channels (ASIC2 claim 2 , ASIC3 or ASIC4) in the absence of ASIC1.4. The antibody or antigen-binding fragment of claim 3 , wherein the antibody or antigen-binding fragment thereof inhibits acid-induced ion currents in cells expressing ASIC1 homomultimers or ASIC1/ASIC3 heteromultimers claim 3 , but does not inhibit acid-induced ion currents in cells expressing ASIC3 homomultimers.5. The antibody or antigen-binding fragment of claim 4 , wherein the antibody or antigen-binding fragment ...

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07-01-2016 дата публикации

Anti-ASIC1 Antibodies and Uses Thereof

Номер: US20160002332A1
Принадлежит:

The present invention provides antibodies and antigen-binding fragments thereof that specifically bind to cells expressing acid-sensing ion channel-1 (ASIC1). According to certain embodiments of the invention, the antibodies inhibit acid-induced, ASIC1-mediated ion currents in cells expressing human ASIC1. The antibodies of the invention are useful for the treatment of pain, including pain associated with surgical intervention and various diseases and disorders. 1. An isolated antibody or antigen-binding fragment thereof that specifically binds cell surface-expressed acid sensing ion channel 1 (ASIC1) (SEQ ID NO:401).2. The antibody or antigen-binding fragment of claim 1 , wherein the antibody or antigen-binding fragment thereof specifically binds cell surface-expressed ASIC1 with an ECof 1 nM or less as measured using fluorescence activated cell sorting (FACS).3. The antibody or antigen-binding fragment of claim 1 , wherein the antibody or antigen-binding fragment thereof inhibits acid-induced claim 1 , ASIC1-mediated ion currents in cells expressing human ASIC1.4. The antibody or antigen-binding fragment of claim 3 , wherein the antibody or antigen-binding fragment thereof inhibits acid-induced cellular calcium flux in cells expressing ASIC1 at pH of about 5.0 to about 6.0 with an ICof 6 nM or less as measured using a FLIPR assay.5. The antibody or antigen-binding fragment of claim 3 , wherein the antibody or antigen-binding fragment thereof inhibits acid-induced ion currents at pH of about 5.0 to about 6.0 with an ICof 10 nM or less as measured using a patch-clamp assay.6. The antibody or antigen-binding fragment of claim 5 , wherein the antibody or antigen-binding fragment thereof comprises: (a) three complementarity determining regions (CDRs) of a heavy chain variable region (HCVR) having an amino acid sequence selected from the group consisting of SEQ ID NOs: 2 claim 5 , 34 claim 5 , 50 claim 5 , 66 claim 5 , 114 claim 5 , 130 claim 5 , 146 claim 5 , 162 claim ...

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10-03-2022 дата публикации

THIN FLUID ABSORBENT CORE-ABSORBENT PAPER

Номер: US20220071818A9
Принадлежит:

The present disclosure relates to fluid absorbent cores including at least one absorption layer, the layer including at least 80% by weight of water-absorbent polymer particles, 0 to 10% by weight of an adhesive and from 0 to 10% by weight of fibrous material, wherein the water-absorbent polymer particles within the absorption layer are water-absorbent polymer particles having a vortex of 40 s or less and having a roundness of 0.79 to 0.85 and/or a CRC of 38 g/g to 85 g/g. 1. A fluid absorbent core comprising:at least one absorption layer, the at least one absorption layer comprising at least 80% by weight of water-absorbent polymer particles,0 to 10% by weight of an adhesive, andfrom 0 to 10% by weight of fibrous material,wherein the water-absorbent polymer particles within the at least one absorption layer are water-absorbent polymer particles having a vortex of 40 s or less and having a roundness of 0.79 to 0.85 and/or a CRC of 38 g/g to 85 g/g.2. A fluid absorbent core according to claim 1 , comprising at least two absorption layers claim 1 , an upper layer and a bottom layer claim 1 , wherein at least the bottom layer comprises water-absorbent polymer particles.3. A fluid absorbent core according to claim 1 , wherein the water-absorbent polymer particles have a CRC of 40 g/g to 80 g/g.4. A fluid absorbent core according to claim 1 , wherein the water-absorbent polymer particles have a roundness of 0.80 to 0.85.5. A fluid absorbent core according to claim 1 , wherein the water-absorbent polymer particles have an extractables content of 10 wt % or less.6. A fluid absorbent core according to claim 1 , wherein the water-absorbent polymer particles have a VAUL (τ=21 g cm) of 1000 s or less.7. A fluid absorbent core according to claim 1 , wherein the water-absorbent polymer particles have a Tof 1000 s or less.8. A fluid absorbent core according to claim 1 , wherein the water-absorbent polymer particles have a FSC (1 min) of at least 25 g/g/s.9. A fluid absorbent core ...

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15-05-2014 дата публикации

V-Ribbed Belt and Method for Manufacturing Same

Номер: US20140135161A1
Принадлежит: THE GATES CORPORATION

A V-ribbed belt that includes a ribbed surface covered with fabric is provided. The fabric is stretchable in two predetermined directions. A method for manufacturing the V-ribbed belt is also provided. The method includes placing a belt matrix about a mandrel, placing a fabric about the external circumference of the belt matrix which wraps around the mandrel, placing the mandrel inside a shell having a plurality of grooves on the internal circumference, expanding the belt matrix and the fabric toward the internal circumference of the shell and thus pressing the fabric onto the internal circumference having the multi-ribbed structure, and curing the belt matrix with the fabric. The fabric is stretchable to accommodate itself to the multi-ribbed structure. 1. A V-ribbed belt comprising a belt matrix and a ribbed surface covered with rib-cover fabric , said rib-cover fabric being stretchable in two predetermined directions;wherein the belt matrix penetrates into the mesh of said rib-cover fabric; andwherein said V-ribbed belt is manufactured by molding, and during said molding, said ribbed surface is molded by expanding said belt matrix together with said rib-cover fabric arranged around the external circumference of said belt matrix toward the inner circumference of a shell having a plurality of grooves for molding a multi-ribbed structure on its internal circumference, and curing said belt matrix with said rib-cover fabric, said rib-cover fabric being stretchable to accommodate itself to said multi-ribbed structure.2. The V-ribbed belt according to claim 1 , wherein said belt matrix is cured after the penetration of said belt matrix into said rib-cover fabric.3. The V-ribbed belt according to claim 1 , wherein the penetration of said belt matrix through the mesh of said rib-cover fabric during the pressurization applied during molding is controlled in order to control characteristics of said ribbed surface.4. The V-ribbed belt according to claim 3 , wherein the ...

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14-04-2016 дата публикации

METHOD FOR INFERRING TYPE OF ROAD SEGMENT

Номер: US20160102987A1
Принадлежит:

Present invention provides a method for inferring the type of a road segment, comprising the steps of: collecting historical driving trajectory data of a plurality of vehicles for a target road segment, performing a statistic on the historical driving trajectory data, and obtaining statistical features of the target road segment; extracting topological features of the target road segment from topological structure data of the road network; merging the statistical features with the topological features of the target road segment, and obtaining an arrogated feature vector of the target road segment; building a logistic regression model according to the arrogated feature vector, and obtaining a first inferred type of the target road segment. The present embodiment considers both the driving trajectory data of a plurality of vehicles and the topological structure data of the road network, the accuracy of the present invention is high, and the inferred result is accurate. 1. A method for inferring a type of a road segment , comprising the steps of:collecting historical driving trajectory data of a plurality of vehicles for a target road segment, performing a statistic on the historical driving trajectory data, and obtaining statistical features of the target road segment;extracting topological features of the target road segment from topological structure data of a road network in which the target road segment locates ;merging the statistical features with the topological features of the target road segment and obtaining an arrogated feature vector of the target road segment; andbuilding a logistic regression model according to the arrogated feature vector and obtaining a first inferred type of the target road segment.2. The method according to claim 1 , wherein after the steps of building the logistic regression model according to the arrogated feature vector and obtaining the first inferred type of the target road segment claim 1 , the method further comprises the ...

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02-04-2020 дата публикации

MUSSEL ADHESIVE PROTEIN PRODUCT AND USE THEREOF FOR TREATING MUCOSAL INFLAMMATION

Номер: US20200101135A1
Принадлежит:

The invention relates to a mussel adhesive protein (MAP) and an application thereof in inhibiting catarrh, and specifically, to applications of a MAP or a product thereof in oral mucositis, rhinitis, otitis media, pharyngitis, laryngitis, bronchitis, esophagitis, gastritis, enteritis, cervicitis, endomyometritis, inflammation resulting from inhalation injury, and oral cavity cancer, nasopharyngeal cancer, carcinoma of middle ear, conjunctival cancer, laryngeal cancer, lung cancer, esophageal cancer, stomach cancer, bowel cancer, cervical cancer, endometrial cancer, and other cancers resulting from the inflammation. The MAP can inhibit symptoms such as flush, fever, swell, and pain owing to catarrh, facilitating healing, relieving itch and pain, and having broad applications in the fields of medicines, cosmetics, medical products, disinfection products, healthcare products, foods, and household goods. 112.-. (canceled)13. A method for treating mucosal inflammation , the method comprising:administering to a subject having mucosal inflammation an effective amount of a composition comprising a mussel adhesive protein (“MAP”), wherein said administering treats the mucosal inflammation, and wherein the MAP comprises one or more of the sub-types selected from the group mefp-1, mefp-2, mefp-3, mefp-4, mefp-5, and mefp-6.14. The method according to claim 13 , wherein the MAP comprises mefp-1.15. The method according to claim 13 , wherein the MAP is present in the composition at a concentration of 0.1 to 15.0 mg/mL.16. The method according to claim 13 , wherein the composition is a liquid formulation claim 13 , a gel formulation claim 13 , or a foam formulation.17. The method according to claim 13 , wherein the composition has a pH in the range of 1.0 to 7.0.18. The method according to claim 13 , wherein the composition has a pH in the range of 3.0 to 6.5.19. The method according to claim 13 , wherein the mucosal inflammation is selected from: oral mucositis claim 13 , ...

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03-06-2021 дата публикации

RESOURCE MAPPING DURING UNIVERSAL RESOURCE LOCATOR CHANGES IN DISTRIBUTED COMPUTING SYSTEMS

Номер: US20210168191A1
Принадлежит:

Technologies are disclosed for resource mapping during URL changes in multi-tenant distributed computing systems. The distributed computing system may resolve a URL by using a tenant and/or site name extracted from the URL to retrieve an entry in a site map table. The entry includes an address to a database that contains the requested content. After a tenant or site name has been changed, or if the tenant or site have been moved, the distributed computing system will resolve pre-existing URLs to the old entry, resulting in a file not found error. In some embodiments, during an operation that changes a tenant or site name, a redirect URL containing the new tenant and/or site name is added to the old entry. When a request addressed to a URL containing the old tenant and/or site names is received, the distributed system sends a redirect response that includes the redirect URL. 1. A computer-implemented method for redirecting a request , the computer-implemented method comprising:receiving the request from a computing device associated with a tenant of a multi-tenant distributed collaboration system, wherein the request includes a uniform resource locator (URL) that includes a name of a site associated with the tenant;extracting the name of the site from the URL;querying a site map table based on the name of the site to retrieve a site map table entry associated the site;determining whether the site map table entry includes a redirect URL associated with the site; adding a resource identifier extracted from the URL to the redirect URL; and', 'responding to the request with a response message that includes the redirect URL., 'in response to determining that the site map table entry includes the redirect URL2. The computer-implemented method of claim 1 , wherein in response to determining that the site map table does not include a redirect URL associated with the site claim 1 , the computer-implemented method further comprises:retrieving a database identifier from the ...

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10-06-2021 дата публикации

THIN FLUID ABSORBENT CORE-ABSORBENT PAPER

Номер: US20210169709A1
Принадлежит:

The present disclosure relates to fluid absorbent cores including at least one absorption layer, the layer including at least 80% by weight of water-absorbent polymer particles, 0 to 10% by weight of an adhesive and from 0 to 10% by weight of fibrous material, wherein the water-absorbent polymer particles within the absorption layer are water-absorbent polymer particles having a vortex of 40 s or less and having a roundness of 0.79 to 0.85 and/or a CRC of 38 g/g to 85 g/g. 1. A fluid absorbent core comprising:at least one absorption layer, the at least one absorption layer comprising at least 80% by weight of water-absorbent polymer particles,0 to 10% by weight of an adhesive, andfrom 0 to 10% by weight of fibrous material,wherein the water-absorbent polymer particles within the at least one absorption layer are water-absorbent polymer particles having a vortex of 40 s or less and having a roundness of 0.79 to 0.85 and/or a CRC of 38 g/g to 85 g/g.2. A fluid absorbent core according to claim 1 , comprising at least two absorption layers claim 1 , an upper layer and a bottom layer claim 1 , wherein at least the bottom layer comprises water-absorbent polymer particles.3. A fluid absorbent core according to claim 1 , wherein the water-absorbent polymer particles have a CRC of 40 g/g to 80 g/g.4. A fluid absorbent core according to claim 1 , wherein the water-absorbent polymer particles have a roundness of 0.80 to 0.85.5. A fluid absorbent core according to claim 1 , wherein the water-absorbent polymer particles have an extractables content of 10 wt % or less.6. A fluid absorbent core according to claim 1 , wherein the water-absorbent polymer particles have a VAUL (τ=21 g cm) of 1000 s or less.7. A fluid absorbent core according to claim 1 , wherein the water-absorbent polymer particles have a Tof 1000 s or less.8. A fluid absorbent core according to claim 1 , wherein the water-absorbent polymer particles have a FSC (1 min) of at least 25 g/g/s.9. A fluid absorbent core ...

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08-09-2022 дата публикации

Computing device, computing apparatus and method of warp accumulation

Номер: US20220284075A1
Автор: Min Gao, Yufei Zhang, ZHU LIANG
Принадлежит: Shanghai Biren Technology Co Ltd

The embodiments of the disclosure relate to a computing device, a computing apparatus, and a method of warp accumulation and relate to the field of computers. The computing device includes a storage unit and an accumulation computing unit coupled to the storage unit. The accumulation computing unit is configured to receive, from a vector processing unit coupled to the computing device, a first warp accumulation instruction, a plurality of first values corresponding to a warp lane number, and a first storage address; generate a current accumulation result based on the plurality of first values in response to the first warp accumulation instruction; and store the current accumulation result in the first storage address in the storage unit to be read by the vector processing unit. In this way, accumulation in a warp may be decoupled to dedicated hardware for processing, and overall accumulation performance may thus be significantly improved.

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07-05-2020 дата публикации

Synchronous Belt Drive System

Номер: US20200141283A1
Принадлежит:

A synchronous belt drive system having: a synchronous belt with a tensile cord of high-modulus fiber such as glass, carbon, PBO, or aramid; a driver sprocket and at least one driven sprocket, at least one of which is an obround sprocket; and a tensioner having: a base having a cylindrical portion extending axially with a radially outer surface and a receiving portion, an eccentric arm pivotally engaged with the radially outer surface, a torsion spring disposed within the receiving portion, the torsion spring applying a biasing force to the eccentric arm, and a pulley journalled to the eccentric arm. Preferably, no one of the eccentric arm, pulley, or torsion spring is axially displaced along an axis A-A from the others. The obround sprocket has a toothed surface and at least one linear portion disposed between two arcuate portions having a constant radius, the linear portion having a predetermined length. 1. A synchronous belt drive system comprising:{'b': '200', 'a synchronous belt () having a tensile cord comprising a high-modulus fiber;'}{'b': '10', 'a driver sprocket and at least one driven sprocket, at least one of which is an obround sprocket (); and'}a tensioner comprising a base having a cylindrical portion extending axially, the cylindrical portion comprising a radially outer surface and a receiving portion that is radially inward of the radially outer surface; an eccentric arm pivotally engaged with the radially outer surface; a torsion spring disposed within the radially inward receiving portion, the torsion spring applying a biasing force to the eccentric arm; and a pulley journalled to the eccentric arm.2. The synchronous belt drive system of wherein the eccentric arm claim 1 , the pulley claim 1 , and the torsion spring are concentrically arranged such that no one of the eccentric arm claim 1 , pulley claim 1 , or torsion spring is axially displaced along an axis A-A from the others.31016141512. The synchronous belt drive system of wherein the obround ...

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21-08-2014 дата публикации

Combinations of Hepatitis C Virus Inhibitors

Номер: US20140235617A1
Принадлежит:

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit Hepatitis C virus (HCV), compositions comprising such compounds, and methods for treating hepatitis C using such combinations. 2. A composition of wherein the compound effective to inhibit the function of HCV polymerase is selected from PSI-6130 claim 1 , PF-00868554 claim 1 , ANA-598 claim 1 , IDX-375 claim 1 , IDX-184 claim 1 , INX-189 claim 1 , BI-207127 claim 1 , PSI-7851 claim 1 , PSI-938 claim 1 , PSI-879 claim 1 , VCH-759 claim 1 , VCH-916 claim 1 , VCH-222 claim 1 , BMS-929075 claim 1 , GS-9190 claim 1 , ABT-333 claim 1 , and ABT-072.4. The composition of wherein the molar ratio of the compound of formula (I) claim 3 , or a pharmaceutically acceptable salt thereof claim 3 , to the compound of formula (II) claim 3 , or a pharmaceutically acceptable salt thereof claim 3 , to the compound of formula (III) claim 3 , or a pharmaceutically acceptable salt thereof claim 3 , is about 1:20:5.5. The composition of wherein the molar ratio of the compound of formula (I) claim 3 , or a pharmaceutically acceptable salt thereof claim 3 , to the compound of formula (II) claim 3 , or a pharmaceutically acceptable salt thereof claim 3 , to the compound of formula (III) claim 3 , or a pharmaceutically acceptable salt thereof claim 3 , is about 1:250:1000.6. A method of treating an HCV infection in a patient claim 1 , comprising administering to the patient a therapeutically effective amount of a composition of .7. The method of wherein the compound effective to inhibit the function of HCV polymerase is selected from PSI-6130 claim 6 , PF-00868554 claim 6 , ANA-598 claim 6 , IDX-375 claim 6 , IDX-184 claim 6 , INX-189 claim 6 , BI-207127 claim 6 , PSI-7851 claim 6 , PSI-938 claim 6 , PSI-879 claim 6 , VCH-759 claim 6 , VCH-916 claim 6 , VCH-222 claim 6 , BMS-929075 claim 6 , GS-9190 claim 6 , ABT-333 claim 6 , and ABT-072.8. A method ...

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30-05-2019 дата публикации

NON-HUMAN ANIMALS COMPRISING A HUMANIZED TRKB LOCUS

Номер: US20190159436A1
Принадлежит:

Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized TRKB locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized TRKB locus express a human TRKB protein or a chimeric transthyretin protein, fragments of which are from human TRKB. Methods are provided for using such non-human animals comprising a humanized TRKB locus to assess in vivo efficacy of human-TRKB-targeting reagents such as nuclease agents designed to target human TRKB. 1. A non-human animal comprising a genetically modified endogenous TrkB locus encoding a TRKB protein , wherein the TRKB protein comprises a cytoplasmic domain , a transmembrane domain , and an extracellular domain , and all or part of the extracellular domain is encoded by a segment of the endogenous TrkB locus that has been deleted and replaced with an orthologous human TRKB sequence.2. The non-human animal of claim 1 , wherein the TRKB protein comprises a human TRKB extracellular domain.3. The non-human animal of claim 2 , wherein the extracellular domain comprises the sequence set forth in SEQ ID NO: 60.4. The non-human animal of claim 2 , wherein all of the extracellular domain is encoded by the segment of the endogenous TrkB locus that has been deleted and replaced with the orthologous human TRKB sequence.5. The non-human animal of claim 1 , wherein the TRKB protein comprises an endogenous signal peptide.6. The non-human animal of claim 5 , wherein the signal peptide comprises the sequence set forth in SEQ ID NO: 51 or 55.7. The non-human animal of claim 5 , wherein all of the signal peptide is encoded by an endogenous TrkB sequence.8. The non-human animal of claim 1 , wherein the TRKB protein comprises an endogenous TRKB transmembrane domain.9. The non-human animal of claim 8 , wherein the transmembrane domain comprises the sequence set forth in SEQ ID NO ...

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30-05-2019 дата публикации

ANTI-TRKB MONOCLONAL ANTIBODIES AND METHODS OF USE

Номер: US20190161551A1
Принадлежит: Regeneron Pharmaceuticals, Inc.

The present invention provides antibodies that bind specifically to TrkB and methods of using the same. According to certain embodiments, the antibodies of the invention are agonist antibodies that are neuroprotective, as shown by their effect on enhancing the survival of retinal ganglion cells in vitro. As such, these agonist antibodies may be used to treat diseases or disorders of the eye, such as, but not limited to glaucoma. In addition, other neuronal diseases or disorders may benefit from treatment with these agonist antibodies, including any disease or disorder characterized in part by neuronal damage. In certain embodiments, the invention includes antibodies that bind TrkB and mediate cell signaling. The antibodies of the invention may be fully human, non-naturally occurring antibodies. 1. An isolated antibody or antigen-binding fragment thereof that binds specifically to tropomyosin receptor kinase B (TrkB) , wherein the antibody or antigen-binding fragment thereof comprises three heavy chain complementarity determining regions (CDRs) (HCDR1 , HCDR2 and HCDR3) contained within a heavy chain variable region (HCVR) comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 2 , 18 , 34 , 49 , 59 and 68; andthree light chain CDRs (LCDR1, LCDR2 and LCDR3) contained within a light chain variable region (LCVR) comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 10, 26, 42, 53, 63 and 72.2. The isolated antibody or antigen-binding fragment of claim 1 , wherein the antibody or antigen-binding fragment thereof comprises the CDRs of a HCVR/LCVR amino acid sequence pair selected from the group consisting of SEQ ID NOs: 2/10 claim 1 , 18/26 claim 1 , 34/42 claim 1 , 49/53 claim 1 , 59/63 and 68/72.3. The isolated antibody or antigen-binding fragment thereof of claim 1 , comprising an HCVR/LCVR amino acid sequence pair selected from the group consisting of SEQ ID NOs: 2/10 claim 1 , 18/26 claim 1 , 34/42 claim 1 , ...

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13-06-2019 дата публикации

METHOD OF WEAVING TUBULAR FABRIC, THE FABRIC, AND A BELT USING THE FABRIC

Номер: US20190177889A1
Автор: Gao Min
Принадлежит:

A method of making weaving a tubular fabric of particular usefulness in power transmission belting and other technical applications. The method includes weaving a secondary, removable warp yarn along with the primary warp yarn in the region of the edge folds on a shuttle loom. The removable warp yarn may be a soluble or meltable yarn. The removable yarn is removed after weaving, resulting in substantially uniform warp density all around the tubular fabric. 1. A method of making woven , continuous , bias fabric comprising:selecting a weft yarn;selecting a primary warp yarn and a removable secondary warp yarn;flat weaving a fabric tube comprising two layers joined at two edge fold regions, with the secondary warp yarn present only in one or more of the two edge fold regions in an amount chosen to reduce the density of primary warp yarns in the fold region of the folds of the fabric to match the warp density in the rest of the fabric; andremoving the secondary warp yarn, andspiral cutting the fabric.2. The method of wherein the secondary warp yarn is a water-soluble yarn.3. The method of wherein said removing comprises dissolving the water-soluble yarn with water.4. The method of wherein said water-soluble yarn comprises polyvinylalcohol fibers.5. The method of wherein the secondary warp yarn is a lower-melting yarn than the primary warp yarn and said removing comprises heating the fabric to melt the secondary warp yarn without melting the primary warp yarn.6. The method of further comprising adjusting the fabric after said removing.7. The method of wherein the resulting woven claim 1 , bias fabric exhibits substantially uniform warp density.8. A continuous claim 1 , woven claim 1 , bias fabric made by the method of .9. A power transmission belt comprising the fabric of .10. The power transmission belt of in the form of a toothed belt comprising the woven fabric as a tooth covering fabric.11. The power transmission belt of in the form of a banded V-belt comprising the ...

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13-06-2019 дата публикации

BIAS TOOTH FABRIC AND TOOTHED POWER TRANSMISSION BELT

Номер: US20190178338A1
Принадлежит:

A cover fabric for a power transmission belt, the fabric woven from warp yarns and weft yarns; the warp yarns and weft yarns each plied from a first filament yarn and a second filament yarn; the first filament yarn comprising higher tensile strength fibers than the second filament yarn; and the fabric woven in a modified twill pattern. A toothed belt with the cover fabric on the teeth, oriented on a bias, with the fabric having a bias angle less than 90°. 1. A cover fabric for a power transmission belt , said fabric woven from warp yarns and weft yarns; said warp yarns and weft yarns each plied from a first filament yarn and a second filament yarn; said first filament yarn comprising higher tensile strength fibers than said second filament yarn; and said fabric woven in a modified twill pattern.2. The cover fabric of wherein the modified twill pattern comprises one or more rows of 1/1 or 2/1 plain weave alternating with one or more rows of a 1/3 or 1/4 or 2/4 satin weave.3. The cover fabric of wherein said warp yarns and weft yarns are each plied with a final twist in the range of 1.0 to 5.0 twists per cm.4. The cover fabric of wherein said warp yarns and said weft yarns have the same composition.5. The cover fabric of wherein said first filament yarn comprises aramid fibers and said second filament yarn comprises nylon fibers.6. The cover fabric of wherein said first filament yarn makes up more than half of the total denier of the warp and weft yarns.7. The cover fabric of oriented on a bias with bias angle less than 90 degrees.8. The cover fabric of comprising a relatively smooth side and a relatively rough side.9. The cover fabric of oriented on a bias with bias angle of about 80 degrees.10. A toothed power transmission belt comprising a bias fabric covering said teeth; wherein said bias fabric is woven from nonstretchable warp yarns and weft yarns oriented at a bias angle of less than 80°; said warp yarns and weft yarns each plied from a first filament yarn and ...

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13-06-2019 дата публикации

TOOTHED POWER TRANSMISSION BELT WITH BACK FABRIC

Номер: US20190178339A1
Принадлежит:

A toothed power transmission belt with a smooth back side surface has a back jacket on the back side surface; wherein the back jacket comprises a closed-mesh, knit fabric tube. The fabric tube may be knitted on a circular weft knitting machine and may be heat set after knitting. The fabric tube may be treated with an epoxy, RFL or other treatment to provide for oil resistance, adhesion, frictional properties, etc. 1. A toothed power transmission belt comprising: a rubber belt body with a toothed surface on one side thereof and a smooth back side surface opposite the one side; a tooth jacket covering the toothed surface; a tensile cord embedded in the belt body; and a back jacket on the back side surface; wherein the back jacket comprises a closed-mesh , knit fabric tube.2. The belt of wherein the fabric tube is knitted with an elastic yarn and an inelastic yarn.3. The belt of wherein the fabric tube is knitted with an elastic yarn and an inelastic yarn fed separately into a circular claim 1 , weft-knitting machine.4. The belt of wherein the elastic yarn comprises polyurethane and the inelastic yarn comprises nylon.5. The belt of wherein the back jacket further comprises a coating comprising an epoxy on the fabric tube.6. The belt of wherein the back jacket further comprises a coating comprising an epoxy and a latex rubber on the fabric tube.7. A method of making the toothed power transmission belt of comprising:providing the closed-mesh, knit fabric tube;treating the knit fabric tube with a coating to make the back jacket;applying the back jacket to a belt slab on a belt-building mandrel;curing the belt slab and cutting to a desired width, resulting in the toothed power transmission belt.8. The method of wherein the treating comprises drying the coated fabric tube in a stress-free process.9. The method of wherein the stress-free process comprises drying the coated fabric tube on a carrier fabric.10. The method of wherein the knit fabric tube comprises an elastic ...

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22-07-2021 дата публикации

Toothed power transmission belt with back fabric

Номер: US20210222756A1
Принадлежит: Gates Corp

A toothed power transmission belt with a smooth back side surface has a back jacket on the back side surface; wherein the back jacket comprises a closed-mesh, knit fabric tube. The fabric tube may be knitted on a circular weft knitting machine and may be heat set after knitting. The fabric tube may be treated with an epoxy, RFL or other treatment to provide for oil resistance, adhesion, frictional properties, etc.

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22-07-2021 дата публикации

TEMPLATE REFINED BI-PREDICTION FOR VIDEO CODING USING ANCHOR POINT

Номер: US20210227216A1
Принадлежит:

In some embodiments, a method performs a first calculation to select an anchor point based on a first reference block in a first reference frame and a second reference block in a second reference frame. The first reference frame is selected as the anchor point. A third reference block in the second reference frame is selected based on the first reference frame being selected as the anchor point. The method performs a second calculation to select the anchor point based on the first reference block in the first reference frame and the third reference block in the second reference frame and determines whether to use the first reference block and the third reference block as a prediction for a current block based on the second calculation. 1. A method comprising:performing, by a computing device, a first calculation to select an anchor point based on a first reference block in a first reference frame and a second reference block in a second reference frame, wherein the first reference frame is selected as the anchor point;selecting, by the computing device, a third reference block in the second reference frame based on the first reference frame being selected as the anchor point;performing, by the computing device, a second calculation to select the anchor point based on the first reference block in the first reference frame and the third reference block in the second reference frame; anddetermining, by the computing device, whether to use the first reference block and the third reference block as a prediction for a current block based on the second calculation.2. The method of claim 1 , wherein performing the first calculation comprises:calculating a first distance between a first template of the first reference block and a second template of the current block;calculating a second distance between a third template of the second reference block and the second template of the current block; andanalyzing the first distance and the second distance to select the first ...

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02-07-2020 дата публикации

TRANSLATING TEXT IN USER INTERFACES BASED ON USER INTERFACE CONTEXTS

Номер: US20200210030A1
Принадлежит:

In some examples, a system receives a user interface (UI) context of a UI, the UI context identifying a relationship between UI elements of the UI, and translates, based on the identified relationship between the UI elements in the UI context, text in the UI from a first language to a second language. 1. A non-transitory machine-readable storage medium storing instructions that upon execution cause a system to:receive a user interface (UI) context of a UI, the UI context identifying a relationship between UI elements of the UI; andtranslate, based on the identified relationship between the UI elements in the UI context, text in the UI from a first language to a second language.2. The non-transitory machine-readable storage medium of claim 1 , wherein the identified relationship comprises a hierarchical relationship between the UI elements.3. The non-transitory machine-readable storage medium of claim 2 , wherein the hierarchical relationship between the UI elements comprises a parent-child relationship claim 2 , and wherein the translated text comprises text in a first UI element of the UI elements.4. The non-transitory machine-readable storage medium of claim 1 , wherein the identified relationship comprises a sibling relationship between the UI elements of a set of the UI elements claim 1 , and wherein the translated text comprises text in a first UI element of the UI elements.5. The non-transitory machine-readable storage medium of claim 1 , wherein the identified relationship comprises a spatial relationship between the UI elements claim 1 , and wherein the translated text comprises text in a first UI element of the UI elements.6. The non-transitory machine-readable storage medium of claim 1 , wherein the text that is translated is part of a first UI element of the UI elements claim 1 , wherein the UI context indicates a type of the first UI element claim 1 , and wherein the translating is further based on the type of the first UI element.7. The non-transitory ...

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09-08-2018 дата публикации

APPLICATIONS OF MUSSEL ADHESIVE PROTEIN PRODUCT IN TREATMENT AND PREVENTION OF DISEASES RELATED TO MELANIN

Номер: US20180221444A1
Принадлежит:

Disclosed are applications of a mussel adhesive protein or preparations thereof in treatment and prevention of diseases related to melanin. Specifically disclosed are applications of a mussel adhesive protein or preparations thereof in treatment and prevention of pigmentations such as chloasma, freckles, melanosis, applications in skin cancers represented by melanoma, and applications in treatment of pigmentation possibly caused by skin diseases or drugs. 122-. (canceled)23. A method for treating or preventing melanin pigmentation , the method comprising:administering to an individual an effective amount of a composition comprising a mussel adhesive protein (“MAP”), wherein said administering treats or prevents melanin pigmentation.24. The method according to claim 23 , wherein the MAP comprises one or more of the sub-types selected from the group: Mytilus edulis foot protein (mefp) subtypes mefp-1 claim 23 , mefp-2 claim 23 , mefp-3 claim 23 , mefp-4 claim 23 , mefp-5 claim 23 , mefp-6; collagens pre-COL-P claim 23 , pre-COL-D claim 23 , pre-COL-NG; and mussel feet matrix proteins PTMP and DTMP.25. The method according to claim 23 , wherein the MAP comprises one or more of the sub-types selected from the group mefp-1 claim 23 , mefp-2 claim 23 , mefp-3 claim 23 , mefp-4 claim 23 , mefp-5 and mefp-6.26. The method according to claim 25 , wherein the MAP comprises mefp-1.27. The method according to claim 23 , wherein the MAP is present in the composition at a concentration of 0.1 to 15.0 mg/ml.28. The method according to claim 23 , wherein the composition is a liquid formulation claim 23 , a gel formulation claim 23 , a lotion claim 23 , a paste claim 23 , or a foam formulation claim 23 , or the composition is administered in the form of a therapy patch.29. The method according to claim 23 , wherein the composition has a pH in the range of 1.0 to 7.0.30. The method according to claim 23 , wherein the composition has a pH in the range of 3.0 to 6.5.31. The method ...

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09-08-2018 дата публикации

Anti-ASIC1 Antibodies and Uses Thereof

Номер: US20180222976A1
Принадлежит:

The present invention provides antibodies and antigen-binding fragments thereof that specifically bind to cells expressing acid-sensing ion channel-1 (ASIC1). According to certain embodiments of the invention, the antibodies inhibit acid-induced, ASIC1-mediated ion currents in cells expressing human ASIC1. The antibodies of the invention are useful for the treatment of pain, including pain associated with surgical intervention and various diseases and disorders. 1. An isolated nucleic acid molecule comprising a nucleic acid sequence encoding a heavy chain variable region (HCVR) of an antibody that binds acid sensing ion channel 1 (ASIC1) , wherein the HCVR comprises a heavy chain complementarity determining region 1 (HCDR1) comprising SEQ ID NO: 36 , a heavy chain complementarity determining region 2 (HCDR2) comprising SEQ ID NO: 38 , and a heavy chain complementarity determining region 3 (HCDR3) comprising SEQ ID NO: 40.2. The nucleic acid molecule of claim 1 , wherein the HCVR comprises the amino acid sequence of SEQ ID NO: 34.3. The nucleic acid molecule of claim 1 , wherein the HCVR comprises an HCDR1 encoded by the nucleotide sequence of SEQ ID NO:35 claim 1 , an HCDR2 encoded by the nucleotide sequence of SEQ ID NO:37 claim 1 , and an HCDR3 encoded by the nucleotide sequence of SEQ ID NO: 39.4. The nucleic acid molecule of claim 1 , wherein the nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO: 33 or a substantially identical sequence having at least 95% homology thereto.5. The nucleic acid molecule of claim 1 , wherein the nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO: 33.6. An isolated nucleic acid molecule comprising a nucleic acid sequence encoding a light chain variable region (LCVR) of an antibody that binds acid sensing on channel 1 (ASIC1) claim 1 , wherein the LCVR comprises a light chain complementarity determining region 1 (LCDR1) comprising SEQ ID NO: 44 claim 1 , a light chain complementarity determining ...

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09-07-2020 дата публикации

MUSSEL ADHESIVE PROTEIN PRODUCT AND APPLICATIONS THEREOF IN SUPPRESSION OF SKIN INFLAMMATIONS

Номер: US20200215166A1
Принадлежит:

Disclosed are applications of a mussel adhesive protein or preparations thereof in suppression of skin inflammations. Specifically disclosed are applications of a mussel adhesive protein, preparations thereof and applications thereof in dermatitis, eczema, skin ulcer, technologies related to burns (comprising skin grafting), perniones, surgical incisions, herpes, abrasions, scars, psoriasis, erythema multiforme, skin damage after radiotherapy, skin cancers, folliculitis, urticaria and drug eruption, and applications in sunburn, polymorphous light eruption, pathological alopecia (comprising hair transplant), acne vulgaris, rosacea (that is, acne rosacea), and the like, and applications in the treatment of otitis externa. 116.-. (canceled)17. A method for treating regular acne or acne rosacea , the method comprising: administering externally to the skin of an individual having regular acne or acne rosacea an effective amount of a composition comprising a mussel adhesive protein (“MAP”) , wherein said skin administering treats the regular acne or acne rosacea.18. The method according to claim 17 , wherein the MAP comprises one or more of the sub-types selected from the group: Mytilus edulis foot protein (mefp) subtypes mefp-1 claim 17 , mefp-2 claim 17 , mefp-3 claim 17 , mefp-4 claim 17 , mefp-5 claim 17 , and mefp-6; collagens pre- COL-P claim 17 , pre-COL-D claim 17 , pre-COL-NG; and mussel feet matrix proteins PTMP and DTMP.19. The method according to claim 17 , wherein the MAP comprises one or more of the sub-types selected from the group mefp-1 claim 17 , mefp-2 claim 17 , mefp-3 claim 17 , mefp-4 claim 17 , mefp-5 and mefp-6.20. The method according to claim 17 , wherein the MAP comprises mefp-1.21. The method according to claim 17 , wherein the MAP is present in the composition at a concentration of 0.1 to 15.0 mg/ml.22. The method according to claim 17 , wherein the composition is a liquid formulation claim 17 , a gel formulation claim 17 , a lotion claim 17 , ...

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09-07-2020 дата публикации

TOPIC IMAGE FLOWS

Номер: US20200218412A1
Принадлежит:

In one example, a system for topic image flows can include a processing resource and a non-transitory computer readable medium having stored thereon instructions to cause the processing resource to generate an image flow of a plurality of topic headers when a user scroll speed of a document including text exceeds a threshold scroll speed, receive a selection of a topic header from the plurality of topic headers, and display, on a user interface, a portion of the document that corresponds to the selected topic header from the plurality of topic headers. 1. A system , comprising:a processing resource; and generate an image flow of a plurality of topic headers when a user scroll speed of a document including text exceeds a threshold scroll speed;', 'receive a selection of a topic header from the plurality of topic headers; and', 'display, on a user interface; a portion of the document that corresponds to the selected topic header from the plurality of topic headers., 'a non-transitory computer readable medium having stored thereon instructions to cause the processing resource to2. The system of claim 1 , wherein the non-transitory computer readable medium comprises instructions to cause the processor to extract titles within the document that correspond to topics of the document.3. The system of claim 2 , wherein the image flow of the plurality of topic headers include a plurality of cards with a header that includes a corresponding title from the extracted titles.4. The system of claim 1 , wherein the computing device includes instructions to:determine a topic based on text of the document being displayed; andgenerate the plurality of topic headers in response to the determined topic.5. The system of claim 4 , wherein the plurality of topic headers are based on a relationship with the topic.6. The system of claim 1 , wherein the threshold scroll speed is based on a reading speed of a user claim 1 , an average words per line of the document claim 1 , and a line height ...

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16-08-2018 дата публикации

Mussel adhesive protein product and applications thereof in suppression of skin inflammations

Номер: US20180228873A1

Disclosed are applications of a mussel adhesive protein or preparations thereof in suppression of skin inflammations. Specifically disclosed are applications of a mussel adhesive protein, preparations thereof and applications thereof in dermatitis, eczema, skin ulcer, technologies related to burns (comprising skin grafting), perniones, surgical incisions, herpes, abrasions, scars, psoriasis, erythema multiforme, skin damage after radiotherapy, skin cancers, folliculitis, urticaria and drug eruption, and applications in sunburn, polymorphous light eruption, pathological alopecia (comprising hair transplant), acne vulgaris, rosacea (that is, acne rosacea), and the like, and applications in the treatment of otitis externa.

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17-08-2017 дата публикации

METHOD AND SYSTEM FOR REAL-TIME POSITIONING OF SMART DEVICE, AND METHOD FOR DETERMINING THE MOTION GESTURE OF MOBILE PHONE

Номер: US20170234686A1
Принадлежит:

The present invention discloses a method for real-time positioning of a smart device, comprising: getting tri-axial acceleration sequences truncated in turn by using a preset time period in the world coordinate individually; acquiring a dominate frequency fby applying fast Fourier transform (FFT) on the truncated Z-axis acceleration sequence, using a band-pass filter with a pass band [f−0.5 Hz, f+0.5 Hz] to filter the truncated tri axial acceleration sequences individually; comparing the time domain waveform form from the filtered Z-axis acceleration sequence with a preset step threshold, and counting each peak above the threshold as a step to acquire a user's step number in the present time period; determining the moving direction of the smart device in the time period by calculating the filtered X-axis and Y-axis acceleration sequences; determining the current position of the smart device by calculating the user's step number and the moving direction of the smart device. 1. A method for real-time positioning of a smart device , comprising the following steps:{'b': '1', 'S: getting tri-axial acceleration in the world coordinate during motion of a smart device by calculating real-time data acquired by an accelerometer, a gravity accelerometer and a magnetic field sensor built in the smart device;'}{'b': '2', 'S: getting tri-axial acceleration sequences truncated in turn by using a preset time period in the world coordinate individually; wherein the preset time period includes 6-8 step periods, and the step period is average step length of a user carrying the smart device;'}{'b': '3', 'sub': step', 'step', 'step, 'S: getting a dominate frequency fby applying fast Fourier transform (FFT) on the truncated Z-axis acceleration sequence, using a band-pass filter with a pass band [f−0.5 Hz, f+0.5 Hz] to filter the truncated tri-axial acceleration sequences individually;'}{'b': '4', "S: comparing the time domain waveform form from the filtered Z-axis acceleration sequence ...

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30-08-2018 дата публикации

MUSSEL ADHESIVE PROTEIN PRODUCT AND USE THEREOF FOR TREATING MUCOSAL INFLAMMATION

Номер: US20180243371A1
Принадлежит:

The invention relates to a mussel adhesive protein (MAP) and an application thereof in inhibiting catarrh, and specifically, to applications of a MAP or a product thereof in oral mucositis, rhinitis, otitis media, pharyngitis, laryngitis, bronchitis, esophagitis, gastritis, enteritis, cervicitis, endomyometritis, inflammation resulting from inhalation injury, and oral cavity cancer, nasopharyngeal cancer, carcinoma of middle ear, conjunctival cancer, laryngeal cancer, lung cancer, esophageal cancer, stomach cancer, bowel cancer, cervical cancer, endometrial cancer, and other cancers resulting from the inflammation. The MAP can inhibit symptoms such as flush, fever, swell, and pain owing to catarrh, facilitating healing, relieving itch and pain, and having broad applications in the fields of medicines, cosmetics, medical products, disinfection products, healthcare products, foods, and household goods. 116.-. (canceled)17. A method for treating mucosal inflammation , the method comprising:administering to a subject having mucosal inflammation an effective amount of a composition comprising a mussel adhesive protein (“MAP”), wherein said administering treats the mucosal inflammation.18. The method according to claim 17 , wherein the MAP comprises one or more of the sub-types selected from the group: Mytilus edulis foot protein (“mefp”) subtypes mefp-1 claim 17 , mefp-2 claim 17 , mefp-3 claim 17 , mefp-4 claim 17 , mefp-5 claim 17 , mefp-6; collagens pre-COL-P claim 17 , pre-COL-D claim 17 , and pre-COL-NG; and mussel feet matrix proteins PTMP and DTMP.19. The method according to claim 17 , wherein the MAP comprises one or more of the sub-types selected from the group mefp-1 claim 17 , mefp-2 claim 17 , mefp-3 claim 17 , mefp-4 claim 17 , mefp-5 claim 17 , and mefp-6.20. The method according to claim 19 , wherein the MAP comprises mefp-1.21. The method according to claim 17 , wherein the MAP is present in the composition at a concentration of 0.1 to 15.0 mg/ml.22. The ...

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14-10-2021 дата публикации

Hydraulically Amplified Dielectric Actuator Taxels

Номер: US20210316446A1
Принадлежит:

A dielectric actuator including an enclosure forming a cavity having a dielectric fluid therein, the enclosure having a base, a flexible membrane and a reversibly-stretchable membrane, and a pair of electrodes, one electrode of the pair of electrodes arranged at the flexible membrane, the other electrode arranged at the base, the pair of electrodes arranged to generate an electric field to an area of the cavity that is filled with the dielectric fluid, wherein when the electric field is generated between the pair of electrodes, an electrostatic pressure in the dielectric fluid causes the flexible membrane to move towards the base, reducing an initial volume of the area of the cavity, increases a pressure of the dielectric fluid inside the cavity, and causes the reversibly-stretchable membrane to bump out to an expanded state. 1. A dielectric actuator comprising:an enclosure forming a cavity having a dielectric fluid therein, the enclosure having a base, a flexible membrane and a reversibly-stretchable membrane; anda pair of electrodes, one electrode of the pair of electrodes arranged at the flexible membrane, the other electrode arranged at the base, the pair of electrodes arranged to generate an electric field to an area of the cavity that is filled with the dielectric fluid,wherein when the electric field is generated between the pair of electrodes, an electrostatic pressure in the dielectric fluid causes the flexible membrane to move towards the base, reducing an initial volume of the area of the cavity, increases a pressure of the dielectric fluid inside the cavity, and causes the reversibly-stretchable membrane to bump out to an expanded state.2. The dielectric actuator according to claim 1 , wherein upon releasing the electric field from the pair of electrodes claim 1 , the flexible membrane reverses back to an initial position to restore the initial volume of the area claim 1 , and the reversibly-stretchable membrane reverts back to an initial state.3. The ...

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11-12-2014 дата публикации

V-Ribbed Belt And Method For Manufacturing Same

Номер: US20140364262A1
Принадлежит:

A V-ribbed belt that includes a ribbed surface covered with fabric is provided. The fabric is stretchable in two predetermined directions. A method for manufacturing the V-ribbed belt is also provided. The method includes placing a belt matrix about a mandrel, placing a fabric about the external circumference of the belt matrix which wraps around the mandrel, placing the mandrel inside a shell having a plurality of grooves on the internal circumference, expanding the belt matrix and the fabric toward the internal circumference of the shell and thus pressing the fabric onto the internal circumference having the multi-ribbed structure, and curing the belt matrix with the fabric. The fabric is stretchable to accommodate itself to the multi-ribbed structure. 1. A V-ribbed belt: , comprising a ribbed surface covered with fabric , said fabric being stretchable in two predetermined directions;wherein said fabric comprises elastic yarn and at least one type of non-elastic yarn, said non-elastic yarn comprises cellulose-based fiber or yarn.2. (canceled)3. The V-ribbed belt according to claim 1 , wherein said elastic yarn includes polyurethane.4. (canceled)5. The V-ribbed belt according to or claim 1 , wherein said non-elastic yarn comprises non-cellulose-based fiber or yarn.6. The V-ribbed belt according to claim 5 , wherein said non-elastic yarn comprises a blend of cellulose-based fiber or yarn and non-cellulose-based fiber or yarn.7. The V-ribbed belt according to claim 6 , wherein a blend of the cellulose-based fiber or yarn and the non-cellulose-based fiber or yarn is made either by blending two types of fibers in yarn spun or twist or by feeding different types of yarns during the fabric manufacturing process.8. The V-ribbed belt according to any one of or claim 6 , wherein said cellulose-based fiber or yarn includes:natural fiber including cotton, linen, jute, hemp, abaca, and bamboo;man-made fiber including rayon and acetate;and combinations thereof.9. The V-ribbed ...

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03-10-2019 дата публикации

Template Refined Bi-Prediction For Video Coding

Номер: US20190306495A1
Принадлежит:

In one embodiment, a method selects a first reference block in a first reference frame and a second reference block in a second reference frame. The first reference block and the second reference block are used to predict a current block. The first reference block is selected as an anchor point. Then, the method searches in the second reference frame for a third reference block and determines whether the third reference block is a better reference block than the second reference block for predicting the current block. 1. A method comprising:selecting, by a computing device, a first reference block in a first reference frame and a second reference block in a second reference frame, the first reference block and the second reference block being used to predict a current block;selecting, by the computing device, the first reference block as an anchor point;searching, by the computing device, in the second reference frame for a third reference block; anddetermining, by the computing device, whether the third reference block is a better reference block than the second reference block for predicting the current block.2. The method of claim 1 , wherein selecting the first reference block as the anchor point comprises:calculating a first distance between a first template of the first reference block and a second template of the current block;calculating a second distance between a third template of the second reference block and the second template of the current block; andanalyzing the first distance and the second distance to select the first reference block as the anchor point.3. The method of claim 2 , wherein the first distance and the second distance are generated by comparing a characteristic between the first template and the second template and the third template and the second template claim 2 , respectively.4. The method of claim 1 , wherein searching in the second reference frame for the third reference block comprises:calculating other distances between other ...

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03-10-2019 дата публикации

Intra Prediction Mode Signaling For Video Coding

Номер: US20190306499A1
Принадлежит:

In one embodiment, a method determines if a first flag for using a most probable mode (MPM) set for intra prediction is set. When the first flag indicates the MPM set is used, the method decodes a first index for the MPM, the first index indicating a first intra prediction mode in the MPM set. When the first flag does not indicate the MPM set is being used, the method determines if a second flag for using a near-MPM set is set. When the second flag indicates the near-MPM set is being used, the method decodes a second index for the near-MPM, the second index indicating a second intra prediction mode in the near-MPM set. When the second flag does not indicate the near-MPM is being used, the method decodes a third index for a non-MPM, the third index indicating a third intra prediction mode in the non-MPM set. 1. A method comprising:determining, by a computing device, if a first flag for using a most probable mode (MPM) set for intra prediction is set;when the first flag indicates the MPM set is used, decoding, by the computing device, a first index for the MPM set, the first index indicating a first intra prediction mode in the MPM set;when the first flag does not indicate the MPM set is being used, determining, by the computing device, if a second flag for using a near-MPM set is set;when the second flag indicates the near-MPM set is being used, decoding, by the computing device, a second index for the near-MPM set, the second index indicating a second intra prediction mode in the near-MPM set; andwhen the second flag does not indicate the near-MPM set is being used, decoding, by the computing device, a third index for a non-MPM set, the third index indicating a third intra prediction mode in the non-MPM set.2. The method of claim 1 , wherein indices in the near-MPM set are selected based on a spanning subspace in the MPM set.3. The method of claim 1 , wherein indices in the near-MPM set are selected by:sorting indices in the MPM set; andselecting indices in the near ...

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03-10-2019 дата публикации

Template Based Adaptive Weighted Bi-Prediction For Video Coding

Номер: US20190306512A1
Принадлежит:

In one embodiment, a method selects a first reference block in a first reference frame and a second reference block in a second reference frame. The first reference block and the second reference block are used to predict a current block in a current frame. A first region is selected based on the first reference block, a second region is selected based the second reference block, and a third region is selected based on the current block. The method compares a characteristic of the first region to a characteristic of the third region and compares a characteristic of the second region to the characteristic of the third region to adaptively determine a first weight for the first reference block and a second weight for the second reference block. Then, a prediction block is calculated for the current block using the first weight and the second weight. 1. A method comprising:selecting, by a computing device, a first reference block in a first reference frame and a second reference block in a second reference frame, the first reference block and the second reference block being used to predict a current block in a current frame;selecting, by the computing device, a first region in the first reference frame based on the first reference block, a second region in the second reference frame based the second reference block, and a third region in the current frame based on the current block;comparing, by the computing device, a characteristic of the first region to a characteristic of the third region and comparing a characteristic of the second region to the characteristic of the third region to adaptively determine a first weight for the first reference block and a second weight for the second reference block; andadaptively, by the computing device, calculating a prediction block for the current block using the first weight and the second weight.2. The method of claim 1 , wherein adaptively calculating the prediction block comprises:applying the first weight to the first ...

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03-10-2019 дата публикации

Reuse Of Block Tree Pattern In Video Compression

Номер: US20190306520A1
Принадлежит:

A method includes transcoding a first block of a video. The first block is associated with a first block tree pattern defining a structure of splitting a block into smaller blocks. A bit string of bits for the first block tree pattern is included in an encoded bitstream for the video. The method determines that the first block tree pattern of the first block can be reused for a second block tree pattern of a second block and includes information in the encoded bitstream that indicates that the first block tree pattern is to be used to decode the second block from the encoded bitstream. 1. A method comprising:transcoding, by a computing device, a first block of a video, the first block associated with a first block tree pattern defining a structure of splitting a block into smaller blocks;including, by the computing device, a bit string of bits for the first block tree pattern in an encoded bitstream for the video;determining, by the computing device, that the first block tree pattern of the first block can be reused for a second block tree pattern of a second block; andincluding, by the computing device, information in the encoded bitstream that indicates that the first block tree pattern is to be used to decode the second block from the encoded bitstream.2. The method of claim 1 , wherein a decoder uses the information that indicates that the first block tree pattern is to be used to decode the second block from the encoded bitstream to determine that a bit string of for the second block tree pattern is not included in the encoded bitstream.3. The method of claim 1 , wherein including the information in the encoded bitstream that indicates that the first block tree pattern is to be used to decode the second block from the encoded bitstream comprises:including a flag with a value set to indicate the second block reuses the first block tree pattern of the first block.4. The method of claim 1 , wherein including the information in the encoded bitstream that indicates ...

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26-11-2015 дата публикации

Combinations of Hepatitis C Virus Inhibitors

Номер: US20150335655A1
Принадлежит:

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit Hepatitis C virus (HCV), compositions comprising such compounds, and methods for treating hepatitis C using such combinations. 2. A composition of wherein the compound effective to inhibit the function of HCV polymerase is selected from PSI-6130 claim 1 , PF-00868554 claim 1 , ANA-598 claim 1 , IDX-375 claim 1 , IDX-184 claim 1 , INX-189 claim 1 , BI-207127 claim 1 , PSI-7851 claim 1 , PSI-938 claim 1 , PSI-879 claim 1 , VCH-759 claim 1 , VCH-916 claim 1 , VCH-222 claim 1 , BMS-929075 claim 1 , GS-9190 claim 1 , ABT-333 claim 1 , and ABT-072.4. The composition of wherein the molar ratio of the compound of formula (I) claim 3 , or a pharmaceutically acceptable salt thereof claim 3 , to the compound of formula (II) claim 3 , or a pharmaceutically acceptable salt thereof claim 3 , to the compound of formula (III) claim 3 , or a pharmaceutically acceptable salt thereof claim 3 , is about 1:20:5.5. The composition of wherein the molar ratio of the compound of formula (I) claim 3 , or a pharmaceutically acceptable salt thereof claim 3 , to the compound of formula (II) claim 3 , or a pharmaceutically acceptable salt thereof claim 3 , to the compound of formula (III) claim 3 , or a pharmaceutically acceptable salt thereof claim 3 , is about 1:250:1000.6. A method of treating an HCV infection in a patient claim 1 , comprising administering to the patient a therapeutically effective amount of a composition of .7. The method of wherein the compound effective to inhibit the function of HCV polymerase is selected from PSI-6130 claim 6 , PF-00868554 claim 6 , ANA-598 claim 6 , IDX-375 claim 6 , IDX-184 claim 6 , INX-189 claim 6 , BI-207127 claim 6 , PSI-7851 claim 6 , PSI-938 claim 6 , PSI-879 claim 6 , VCH-759 claim 6 , VCH-916 claim 6 , VCH-222 claim 6 , BMS-929075 claim 6 , GS-9190 claim 6 , ABT-333 claim 6 , and ABT-072.8. A method ...

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15-10-2020 дата публикации

APPLICATIONS OF MUSSEL ADHESIVE PROTEIN PRODUCT IN TREATMENT AND PREVENTION OF DISEASES RELATED TO MELANIN

Номер: US20200323956A1
Принадлежит:

Disclosed are applications of a mussel adhesive protein or preparations thereof in treatment and prevention of diseases related to melanin. Specifically disclosed are applications of a mussel adhesive protein or preparations thereof in treatment and prevention of pigmentations such as chloasma, freckles, melanosis, applications in skin cancers represented by melanoma, and applications in treatment of pigmentation possibly caused by skin diseases or drugs. 122.-. (canceled)23M. edulis. A method for treating melanin pigmentation , the method comprising administering to an individual an effective amount of a composition comprising a mussel adhesive protein (MAP) , wherein the MAP comprises one or more of the sub-types selected from the group consisting of foot protein 1 (mefp-1) , mefp-2 , mefp-3 , mefp-4 , mefp-5 and mefp-6 , wherein said administering treats melanin pigmentation.24. The method according to claim 23 , wherein the MAP comprises mefp-1.25. The method according to claim 23 , wherein the MAP is present in the composition at a concentration of 0.1 to 15.0 mg/ml.26. The method according to claim 23 , wherein the composition is a liquid formulation claim 23 , a gel formulation claim 23 , a lotion claim 23 , a paste claim 23 , a foam formulation claim 23 , or in the form of a therapy patch.27. The method according to claim 23 , wherein the composition has a pH in the range of 1.0 to 7.0.28. The method according to claim 23 , wherein the composition has a pH in the range of 3.0 to 6.5.29. The method according to claim 23 , wherein the melanin pigmentation is selected from the group: chloasma claim 23 , freckles claim 23 , melanosis claim 23 , chromatosis and skin cancers.30. The method according to claim 23 , wherein the melanin pigmentation comprises melanoma or chromatosis caused by exposure to the sun or a skin disease.31. The method according to claim 23 , wherein the melanin pigmentation is melanin pigmentation after burns.32. The method according to ...

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29-12-2022 дата публикации

Anti-Trkb Monoclonal Antibodies And Methods of Use

Номер: US20220411515A1
Автор: Min Gao, Susan Croll, Ying Hu
Принадлежит: Regeneron Pharmaceuticals Inc

The present invention provides antibodies that bind specifically to TrkB and methods of using the same. According to certain embodiments, the antibodies of the invention are agonist antibodies that are neuroprotective, as shown by their effect on enhancing the survival of retinal ganglion cells in vitro. As such, these agonist antibodies may be used to treat diseases or disorders of the eye, such as, but not limited to glaucoma. In addition, other neuronal diseases or disorders may benefit from treatment with these agonist antibodies, including any disease or disorder characterized in part by neuronal damage. In certain embodiments, the invention includes antibodies that bind TrkB and mediate cell signaling. The antibodies of the invention may be fully human, non-naturally occurring antibodies.

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21-04-2011 дата публикации

Combinations of a specific hcv ns5a inhibitor and an hcv ns3 protease inhibitor

Номер: WO2011046811A1
Принадлежит: BRISTOL-MYERS SQUIBB COMPANY

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit Hepatitis C virus (HCV), compositions comprising such compounds, and methods for treating Hepatitis C using such combinations.

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09-02-2012 дата публикации

Combinations of hepatitis c virus inhibitors

Номер: WO2012018829A1
Принадлежит: BRISTOL-MYERS SQUIBB COMPANY

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit Hepatitis C virus (HCV), compositions comprising such compounds, and methods for treating hepatitis C using such combinations. To achieve maximal efficacy and to potentially eradicate the virus, it will be critical to utilize combination therapies, especially those targeting distinct HCV viral targets. In vitro replicon-based combination studies have shown that additive to synergistic effects can be achieved with various combinations of HCV inhibitors.

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03-05-2016 дата публикации

Hepatitis C virus inhibitors

Номер: US9326973B2
Принадлежит: Bristol Myers Squibb Co

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

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19-01-2012 дата публикации

Methods to identify combinations of ns5a targeting compounds that act synergistically to inhibit hepatitis c virus replication

Номер: WO2012009394A2
Принадлежит: BRISTOL-MYERS SQUIBB COMPANY

The present invention is based on the surprising finding that pairs of HCV NS5A-targeting inhibitors can be identified which display similar resistance profiles yet, when combined, exhibit synergistic inhibition of wild type replicons and/or replicons carrying mutations conferring resistance to the HCV NS5A-targeting inhibitor. In addition, combinations of these molecules result in a higher genetic barrier to resistance, demonstrating their potential utility as novel combination therapies for treatment of HCV.

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27-02-2007 дата публикации

Iminothiazolidinones as inhibitors of HCV replication

Номер: US7183302B2
Принадлежит: Bristol Myers Squibb Co

Compounds having the structure of formula I are described wherein R, R′, R 1 , R 2 , and R 3 are as defined in the specification. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular the function of the HCV NS5A protein.

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27-03-2012 дата публикации

Inhibitors of HCV replication

Номер: US8143288B2
Принадлежит: Bristol Myers Squibb Co

Compounds having the structure of formula I are described. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular can inhibit the function of the HCV NS5A protein.

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09-04-2013 дата публикации

Combinations of hepatitis C virus inhibitors

Номер: US8415374B2
Принадлежит: Bristol Myers Squibb Co

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit Hepatitis C virus (HCV), compositions comprising such compounds, and methods for treating Hepatitis C using such combinations.

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14-12-2006 дата публикации

Inhibitors of hcv replication

Номер: WO2006133326A1
Принадлежит: BRISTOL-MYERS SQUIBB COMPANY

Compounds having the structure of formula I are described. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular can inhibit the function of the HCV NS5A protein.

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07-12-2006 дата публикации

Inhibitors of HCV replication

Номер: US20060276511A1
Принадлежит: Bristol Myers Squibb Co

Compounds having the structure of formula I are described. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular can inhibit the function of the HCV NS5A protein.

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18-07-2013 дата публикации

Hepatitis c virus inhibitors

Номер: WO2013106520A1
Принадлежит: BRISTOL-MYERS SQUIBB COMPANY

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

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06-02-2020 дата публикации

Feminine hygiene absorbent article

Номер: WO2020025400A1
Принадлежит: BASF SE

The present invention relates to a feminine hygiene absorbent article, comprising (A) an upper liquid-pervious layer, (B) a lower liquid-impervious layer, (C) a fluid-absorbent core between the layer (A) and the layer (B), comprising 5% to 50% by weight of water-absorbent polymer particles G and not more than 95% by weight of fibrous material, based on the sum of water-absorbent polymer particles G and fibrous material; (D) an optional acquisition-distribution layer between (A) and (C), (E) an optional tissue layer disposed immediately above and/or below (C); and (F) other optional components, wherein the water-absorbent polymer particles G being obtainable by agglomerating a blend of non-surface post-crosslinked fine water-absorbent polymer particles and surface post-crosslinked fine water-absorbent polymer particles drying, grinding, sieving and classification of the agglomerated water-absorbent polymer particles.

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24-10-2019 дата публикации

Thin fluid absorbent core-absorbent paper

Номер: WO2019201668A1
Принадлежит: BASF SE

The present invention relates to fluid absorbent cores (80) comprising at least one absorption layer, the layer comprising at least 80 % by weight of water-absorbent polymer particles, 0 to 10% by weight of an adhesive and from 0 to 10 % by weight of fibrous material, wherein the water- absorbent polymer particles within the absorption layer are water-absorbent polymer particles H having a vortex of 40 s or less and having a roundness of 0.79 to 0.85 and/or a CRC of 38 g/g to 85 g/g.

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19-02-2004 дата публикации

Combination pharmaceutical agents as inhibitors of hcv replication

Номер: WO2004014313A2
Принадлежит: BRISTOL-MYERS SQUIBB COMPANY

Disclosed are combination pharmaceutical agents for the treatment of an HCV infection comprising a compound effective to inhibit the function of the HCV NS5A protein and another compound having anti-HCV activity. Compounds which can inhibit the function of the NS5A protein having the structure of formula (I) are described; wherein R, R', R1, R2, and R3 are as defined in the specification. The other compounds having anti-HCV activity are effective to inhibit the function of a target selected from the group consisting of HCV metalloprotease, HCV serine protease, HCV polymerase, HCV helicase, HCV NS4B protein, HCV entry, HCV assembly, HCV egress, HCV NS5A protein, IMPDH and a nucleoside analog for the treatment of an HCV infection.

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10-12-2014 дата публикации

Anti-asic1 antibodies and uses thereof

Номер: EP2809681A1
Принадлежит: Regeneron Pharmaceuticals Inc

The present invention provides antibodies and antigen-binding fragments thereof that specifically bind to cells expressing acid-sensing ion channel-1 (ASIC1). According to certain embodiments of the invention, the antibodies inhibit acid-induced, ASIC1-mediated ion currents in cells expressing human ASIC1. The antibodies of the invention are useful for the treatment of pain, including pain associated with surgical intervention and various diseases and disorders.

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24-02-2021 дата публикации

Thin fluid absorbent core-absorbent paper

Номер: EP3781107A1
Принадлежит: BASF SE

The present invention relates to fluid absorbent cores (80) comprising at least one absorption layer, the layer comprising at least 80 % by weight of water-absorbent polymer particles, 0 to 10% by weight of an adhesive and from 0 to 10 % by weight of fibrous material, wherein the water- absorbent polymer particles within the absorption layer are water-absorbent polymer particles H having a vortex of 40 s or less and having a roundness of 0.79 to 0.85 and/or a CRC of 38 g/g to 85 g/g.

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25-01-2018 дата публикации

Mussel adhesive protein product and applications thereof in suppression of skin inflammations

Номер: AU2015402832A1

Disclosed are applications of a mussel adhesive protein or preparations thereof in suppression of skin inflammations. Specifically disclosed are applications of a mussel adhesive protein, preparations thereof and applications thereof in dermatitis, eczema, skin ulcer, technologies related to burns (comprising skin grafting), perniones, surgical incisions, herpes, abrasions, scars, psoriasis, erythema multiforme, skin damage after radiotherapy, skin cancers, folliculitis, urticaria and drug eruption, and applications in sunburn, polymorphous light eruption, pathological alopecia (comprising hair transplant), acne vulgaris, rosacea (that is, acne rosacea), and the like, and applications in the treatment of otitis externa.

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19-03-2009 дата публикации

V-ribbed belt and method for manufacturing same

Номер: CA2698365A1
Принадлежит: Individual

A V-ribbed belt that includes a ribbed surface covered with fabric is provided. The fabric is stretchable in two predetermined directions. A method for manufacturing the V- ribbed belt is also provided. The method includes placing a belt matrix about a mandrel, placing a fabric about the external circumference of the belt matrix which wraps around the mandrel, placing the mandrel inside a shell having a plurality of grooves on the internal circumference, expanding the belt matrix and the fabric toward the internal circumference of the shell and thus pressing the fabric onto the internal circumference having the multi-ribbed structure, and curing the belt matrix with the fabric. The fabric is stretchable to accommodate itself to the multi-ribbed structure.

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18-07-2013 дата публикации

Hepatitis c virus inhibitors

Номер: CA2863268A1
Принадлежит: Bristol Myers Squibb Co

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

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01-06-2016 дата публикации

Gearing control device of bicycle

Номер: TWM522908U
Автор: Min-Sheng Gao, zhi-li Wang
Принадлежит: Cycling & Health Tech Ind R&D

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30-06-2010 дата публикации

V-ribbed belt and method for manufacturing same

Номер: EP2201266A1
Принадлежит: Gates Corp

A V-ribbed belt that includes a ribbed surface covered with fabric is provided. The fabric is stretchable in two predetermined directions. A method for manufacturing the V- ribbed belt is also provided. The method includes placing a belt matrix about a mandrel, placing a fabric about the external circumference of the belt matrix which wraps around the mandrel, placing the mandrel inside a shell having a plurality of grooves on the internal circumference, expanding the belt matrix and the fabric toward the internal circumference of the shell and thus pressing the fabric onto the internal circumference having the multi-ribbed structure, and curing the belt matrix with the fabric. The fabric is stretchable to accommodate itself to the multi-ribbed structure.

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30-05-2018 дата публикации

Applications of mussel adhesive protein product in treatment and prevention of diseases related to melanin

Номер: EP3326640A1

Disclosed are applications of a mussel adhesive protein or preparations thereof in treatment and prevention of diseases related to melanin. Specifically disclosed are applications of a mussel adhesive protein or preparations thereof in treatment and prevention of pigmentations such as chloasma, freckles, melanosis, applications in skin cancers represented by melanoma, and applications in treatment of pigmentation possibly caused by skin diseases or drugs.

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15-12-2020 дата публикации

Template based adaptive weighted bi-prediction for video coding

Номер: US10869042B2
Принадлежит: HULU LLC

In one embodiment, a method selects a first reference block in a first reference frame and a second reference block in a second reference frame. The first reference block and the second reference block are used to predict a current block in a current frame. A first region is selected based on the first reference block, a second region is selected based the second reference block, and a third region is selected based on the current block. The method compares a characteristic of the first region to a characteristic of the third region and compares a characteristic of the second region to the characteristic of the third region to adaptively determine a first weight for the first reference block and a second weight for the second reference block. Then, a prediction block is calculated for the current block using the first weight and the second weight.

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07-05-2020 дата публикации

Anti-TrkB monoclonal antibodies and methods of use

Номер: AU2018375340A1
Принадлежит: Regeneron Pharmaceuticals Inc

Antibodies that bind specifically to TrkB and methods of using the same are disclosed. Agonist antibodies that are neuroprotective, as shown by their effect on enhancing the survival of retinal ganglion cells in vitro are disclosed, and these agonist antibodies may be used in treatments such as disorders of the eye, including glaucoma. In addition, other neuronal diseases or disorders benefit from treatment with these agonist antibodies, including those characterized in part by neuronal damage. In certain embodiments, the invention includes antibodies that bind TrkB and mediate cell signaling. The antibodies of the invention may be fully human, non-naturally occurring antibodies formulated with excipients for injection.

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29-05-2020 дата публикации

ANTI-ASIC1 ANTIBODIES AND THEIR USES

Номер: CY1121368T1
Принадлежит: Regeneron Pharmaceuticals, Inc.

Η παρούσα εφεύρεση παρέχει αντισώματα και αντιγονοδεσμευτικά θραύσματα αυτών τα οποία δεσμεύονται ειδικά σε κύτταρα που εκφράζουν τον δίαυλο ιόντων αίσθησης οξέων 1 (ASIC1). Σύμφωνα με ορισμένες υλοποιήσεις της εφεύρεσης, τα αντισώματα αναστέλλουν τα επαγόμενα από οξέα, προκαλούμενα από τον ASIC1 ιοντικά ρεύματα στα κύτταρα που εκφράζουν τον ανθρώπινο ASIC1. Τα αντισώματα της εφεύρεσης είναι χρήσιμα για τη θεραπεία του πόνου, συμπεριλαμβανομένου του πόνου που σχετίζεται με χειρουργική επέμβαση, καθώς και με διάφορες νόσους και διαταραχές. The present invention provides antibodies and antigen-binding fragments thereof which specifically bind to cells expressing the acid sensing ion channel 1 (ASIC1). According to certain embodiments of the invention, the antibodies inhibit the acid-induced ASIC1-induced ionic currents in the cells expressing human ASIC1. The antibodies of the invention are useful in the treatment of pain, including pain associated with surgery, as well as various diseases and disorders.

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31-05-2019 дата публикации

Anti-asic1 antibodies and uses thereof

Номер: PL2809681T3
Принадлежит: Regeneron Pharma

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05-02-1998 дата публикации

Cdo tumor suppressor gene and protein

Номер: WO1998004697A1

The present invention relates to a Class II tumor suppressor gene designated 'cdo' (Cam-related gene/down-regulated by oncogenes), which is down-regulated at the mRNA level in transformed cells, and is expressed at extremely low levels in adult tissues.

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03-05-2012 дата публикации

Combinations of a specific HCV NS5A inhibitor and an HCV NS3 protease inhibitor

Номер: AU2010307144A1
Принадлежит: Bristol Myers Squibb Co

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit Hepatitis C virus (HCV), compositions comprising such compounds, and methods for treating Hepatitis C using such combinations.

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26-01-2017 дата публикации

Use of map product to treat and prevent melanin-related diseases

Номер: CA2992315A1

Disclosed are applications of a mussel adhesive protein or preparations thereof in treatment and prevention of diseases related to melanin. Specifically disclosed are applications of a mussel adhesive protein or preparations thereof in treatment and prevention of pigmentations such as chloasma, freckles, melanosis, applications in skin cancers represented by melanoma, and applications in treatment of pigmentation possibly caused by skin diseases or drugs.

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11-04-2017 дата публикации

Apparatus and method for fast evaluation of electroplating formulation performance in microvia filling

Номер: US9617653B2

The presently claimed invention provides an electrochemical analytical apparatus and a method for evaluating performance of electroplating formulations of electrolyte solutions used for via filling. The electrochemical analytical apparatus comprises an electric power generating device, an electrical output signal measurement device, an electrochemical measurement device, and a motion generator. The electrochemical measurement device of the present invention comprises a supporting structure, a cavity, a cavity electrode, and a surface electrode. The electrical output signals of the cavity electrode and the surface electrode are measured during electroplating for calculating a filling performance value. The presently claimed invention provides an accurate, fast and cost effective method for evaluating performance of electroplating formulations, following with choosing the electroplating formulation of the highest FP value for actual microvia filling process.

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22-04-2020 дата публикации

A MANIFOLD FORMULATION TO IMPROVE METAL RECOVERY IN MINING APPLICATIONS

Номер: AR113381A1

Se proveen una composición colectora y métodos para elaborarla y usarla. El colector se sintetiza a partir de uno o más ácidos grasos de aceite de resina y una o más poliaminas. Una suspensión o suspensión líquida que comprende uno o más particulados se puede poner en contacto con el colector para producir una mezcla tratada. El colector contiene subcomponentes con funcionalidades de amidoamina e imidazolina que dan mayor recuperación de los minerales deseados respecto a métodos conocidos. A collecting composition and methods for making and using it are provided. The collector is synthesized from one or more tall oil fatty acids and one or more polyamines. A liquid suspension or suspension comprising one or more particulates can be contacted with the collector to produce a treated mixture. The collector contains subcomponents with amidoamine and imidazoline functionalities that give greater recovery of the desired minerals compared to known methods.

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22-05-2018 дата публикации

Mussel adhesive protein product and applications thereof in suppression of skin inflammations.

Номер: MX2018000333A

Se describen las aplicaciones de una proteína adhesiva de mejillón o preparaciones de esta para suprimir inflamaciones de la piel. Específicamente, se describen aplicaciones de una proteína adhesiva de mejillón, preparaciones de esta y aplicaciones de esta en dermatitis, eccema, úlcera de piel, tecnologías relacionadas a las quemaduras (que comprenden injerto de piel), sabañones, incisiones quirúrgicas, herpes, abrasiones, cicatrices, psoriasis, eritema multiforme, daño de la piel luego de radioterapia, cáncer de piel, foliculitis, urticaria y erupción causada por fármacos, y aplicaciones en quemaduras causadas por el sol, erupción lumínica polimorfa, alopecia patológica (que comprende trasplante capilar), acné vulgar, rosácea (es decir, acné rosácea) y similares, y aplicaciones en el tratamiento de otitis externa.

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22-09-2020 дата публикации

Intra prediction mode signaling for video coding

Номер: US10785479B2
Принадлежит: HULU LLC

In one embodiment, a method determines if a first flag for using a most probable mode (MPM) set for intra prediction is set. When the first flag indicates the MPM set is used, the method decodes a first index for the MPM, the first index indicating a first intra prediction mode in the MPM set. When the first flag does not indicate the MPM set is being used, the method determines if a second flag for using a near-MPM set is set. When the second flag indicates the near-MPM set is being used, the method decodes a second index for the near-MPM, the second index indicating a second intra prediction mode in the near-MPM set. When the second flag does not indicate the near-MPM is being used, the method decodes a third index for a non-MPM, the third index indicating a third intra prediction mode in the non-MPM set.

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17-11-2022 дата публикации

Non-human animals comprising a humanized trkb locus

Номер: US20220361464A1
Принадлежит: Regeneron Pharmaceuticals Inc

Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized TRKB locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized TRKB locus express a human TRKB protein or a chimeric transthyretin protein, fragments of which are from human TRKB. Methods are provided for using such non-human animals comprising a humanized TRKB locus to assess in vivo efficacy of human-TRKB-targeting reagents such as nuclease agents designed to target human TRKB.

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08-08-2013 дата публикации

Anti-asic1 antibodies and uses thereof

Номер: CA2862332A1
Принадлежит: Regeneron Pharmaceuticals Inc

The present invention provides antibodies and antigen-binding fragments thereof that specifically bind to cells expressing acid-sensing ion channel-1 (ASIC1). According to certain embodiments of the invention, the antibodies inhibit acid-induced, ASIC1-mediated ion currents in cells expressing human ASIC1. The antibodies of the invention are useful for the treatment of pain, including pain associated with surgical intervention and various diseases and disorders.

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23-02-2017 дата публикации

Map product and use thereof for inhibiting mucosal inflammations

Номер: CA2995549A1

The invention relates to a mussel adhesive protein (MAP) and an application thereof in inhibiting catarrh, and specifically, to applications of a MAP or a product thereof in oral mucositis, rhinitis, otitis media, pharyngitis, laryngitis, bronchitis, esophagitis, gastritis, enteritis, cervicitis, endomyometritis, inflammation resulting from inhalation injury, and oral cavity cancer, nasopharyngeal cancer, carcinoma of middle ear, conjunctival cancer, laryngeal cancer, lung cancer, esophageal cancer, stomach cancer, bowel cancer, cervical cancer, endometrial cancer, and other cancers resulting from the inflammation. The MAP can inhibit symptoms such as flush, fever, swell, and pain owing to catarrh, facilitating healing, relieving itch and pain, and having broad applications in the fields of medicines, cosmetics, medical products, disinfection products, healthcare products, foods, and household goods.

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03-08-2020 дата публикации

Anti-trkb monoclonal antibodies and methods of use.

Номер: MX2020003550A
Автор: Min Gao, Susan D Croll, Ying Hu
Принадлежит: Regeneron Pharma

Se describen los anticuerpos que se unen específicamente a TrkB y los métodos para usarlos. Los anticuerpos agonistas que son neuroprotectores, como se muestra por su efecto sobre la mejora de la supervivencia de las células ganglionares de la retina in vitro, se divulgan, y estos anticuerpos agonistas pueden usarse en tratamientos tales como trastornos del ojo, incluido el glaucoma. Además, otras enfermedades o trastornos neuronales se benefician del tratamiento con estos anticuerpos agonistas, incluidos aquellos caracterizados en parte por daño neuronal. En ciertas realizaciones, la invención incluye anticuerpos que se unen a TrkB y median la señalización celular. Los anticuerpos de la invención pueden ser completamente humanos, anticuerpos no naturales formulados con excipientes para inyección.

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19-02-2004 дата публикации

Iminothiazolidinones as inhibitors of hcv replication

Номер: WO2004014852A2
Принадлежит: BRISTOL-MYERS SQUIBB COMPANY

Compounds having the structure of formula I are described (I) wherein R, R', R1, R2, and R3 are as defined in the specification. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular the function of the HCV NS5A protein.

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19-03-2009 дата публикации

V-ribbed belt and method for manufacturing same

Номер: WO2009034748A1

A V-ribbed belt that includes a ribbed surface covered with fabric is provided. The fabric is stretchable in two predetermined directions. A method for manufacturing the V- ribbed belt is also provided. The method includes placing a belt matrix about a mandrel, placing a fabric about the external circumference of the belt matrix which wraps around the mandrel, placing the mandrel inside a shell having a plurality of grooves on the internal circumference, expanding the belt matrix and the fabric toward the internal circumference of the shell and thus pressing the fabric onto the internal circumference having the multi-ribbed structure, and curing the belt matrix with the fabric. The fabric is stretchable to accommodate itself to the multi-ribbed structure.

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08-05-2012 дата публикации

Combinations of a specific hcv ns5a inhibitor and an hcv ns3 protease inhibitor.

Номер: MX2012003835A
Принадлежит: Bristol Myers Squibb Co

La presente invención se refiere en general a compuestos antivirales, y más específicamente se dirige a combinaciones de compuestos los cuales pueden inhibir el virus de la Hepatitis C (HCV), composiciones que comprenden tales compuestos, y métodos para tratar la Hepatitis C usando tales combinaciones.

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01-04-2010 дата публикации

V-ribbed belt and method for manufacturing same.

Номер: MX2010002689A
Принадлежит: Gates Corp

Se proporciona una banda en y con costillas que incluye una superficie acostillada cubierta con tela. La tela se puede extender en dos direcciones predeterminadas. Tambi?n se proporciona un m?todo para fabricar la banda en y con costillas. El m?todo incluye colocar una matriz de la banda alrededor de un mandril, colocar una tela alrededor de la circunferencia externa de la matriz que se enrolla alrededor del mandril, colocar el mandril dentro de una concha que tiene una pluralidad de ranuras en la circunferencia interna, expandiendo la matriz y la tela hacia la circunferencia interna de la concha y presionando la tela en la circunferencia interna que tiene una estructura de costillas m?ltiples y curar la matriz con la tela. La tela es extensible para que se acomode en la estructura de costillas m?ltiples.

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30-04-2012 дата публикации

COMBIANTIONS OF A HCV NS5A SPECIFIC INHIBITOR AND HCV NS3 PROTEASA INHIBITOR

Номер: CO6430507A2
Принадлежит: Bristol Myers Squibb Co

La presente invención se refiere en general a compuestos antivirales, y más específicamente se dirige a combinaciones de compuestos los cuales pueden inhibir elvirus de la Hepatitis C (HCV), composiciones que comprenden tales compuestos, y métodos para tratar la Hepatitis C usando tales combinaciones. The present invention relates generally to antiviral compounds, and more specifically it is directed to combinations of compounds which can inhibit Hepatitis C virus (HCV), compositions comprising such compounds, and methods for treating Hepatitis C using such combinations.

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06-06-2019 дата публикации

Anti-trkb monoclonal antibodies and methods of use

Номер: CA3083452A1
Принадлежит: Regeneron Pharmaceuticals Inc

Antibodies that bind specifically to TrkB and methods of using the same are disclosed. Agonist antibodies that are neuroprotective, as shown by their effect on enhancing the survival of retinal ganglion cells in vitro are disclosed, and these agonist antibodies may be used in treatments such as disorders of the eye, including glaucoma. In addition, other neuronal diseases or disorders benefit from treatment with these agonist antibodies, including those characterized in part by neuronal damage. In certain embodiments, the invention includes antibodies that bind TrkB and mediate cell signaling. The antibodies of the invention may be fully human, non-naturally occurring antibodies formulated with excipients for injection.

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02-12-2021 дата публикации

Bias tooth fabric and toothed power transmission belt

Номер: AU2018385308B9
Принадлежит: Gates Corp

A cover fabric for a power transmission belt, the fabric woven from warp yarns and weft yarns; the warp yarns and weft yarns each plied from a first filament yarn and a second filament yarn; the first filament yarn comprising higher tensile strength fibers than the second filament yarn; and the fabric woven in a modified twill pattern. A toothed belt with the cover fabric on the teeth, oriented on a bias, with the fabric having a bias angle less than 90.

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28-03-2013 дата публикации

Combinations of hepatitis c virus inhibitors

Номер: SG187193A1
Принадлежит: Bristol Myers Squibb Co

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit Hepatitis C virus (HCV), compositions comprising such compounds, and methods for treating hepatitis C using such combinations. To achieve maximal efficacy and to potentially eradicate the virus, it will be critical to utilize combination therapies, especially those targeting distinct HCV viral targets. In vitro replicon-based combination studies have shown that additive to synergistic effects can be achieved with various combinations of HCV inhibitors.

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20-06-2023 дата публикации

Sistema de acionamento por correia síncrona

Номер: BR112020000200B1
Принадлежит: Gates Corporation

Um sistema de acionamento por correia síncrona tenho: uma correia síncrona com um fio de tração de fibra de alto módulo tal como de vidro, carbono, PBO, ou aramida; uma roda dentada acionadora e pelo menos uma roda dentada acionada, pelo menos uma das quais é uma roda dentada oblonga; e um tracionador tendo: uma base tendo uma porção cilíndrica estendendo-se axialmente com uma superfície radialmente externa e uma porção de recepção, um braço excêntrico engatado pivotavelmente com a superfície radialmente externa, uma mola de torção disposta dentro da porção de recepção, a mola de torção aplicando uma força tensionadora ao braço excêntrico, e uma polia articulada no braço excêntrico. Preferivelmente, nenhum dentre o braço excêntrico, a polia ou a mola de torção é axialmente deslocado ao longo de um eixo A-A dos outros. A roda dentada oblonga tem uma superfície denteada e pelo menos uma porção linear disposta entre duas porções arqueadas tendo um raio constante, a porção linear tendo um comprimento predeterminado.

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23-01-2024 дата публикации

ヒト化trkb遺伝子座を含む非ヒト動物

Номер: JP2024009849A
Принадлежит: Regeneron Pharmaceuticals Inc

【課題】ヒトTRKB標的化試薬の真のヒト標的または真のヒト標的の密接な近似を提供し、これにより、生きている動物における斯かる薬剤の有効性および作用機序の検査、ならびに薬物動態および薬力学研究を可能にする、適した非ヒト動物を提供する。【解決手段】遺伝子改変された内在性TrkB遺伝子座を含むマウスであって、前記遺伝子改変された内在性TrkB遺伝子座が、トロポミオシン受容体キナーゼB(TRKB)タンパク質をコードし、前記TRKBタンパク質が、内在性TRKBシグナルペプチド、内在性TRKB細胞質ドメイン、内在性TRKB膜貫通ドメインおよびヒトTRKB細胞外ドメインを含み、前記細胞外ドメインの全体が、欠失されてオルソロガスヒトTRKB配列で置き換えられた前記内在性TrkB遺伝子座のセグメントによりコードされる、マウスを提供する。【選択図】図4

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27-03-2024 дата публикации

Rats comprising a humanized trkb locus

Номер: EP4299732A3
Принадлежит: Regeneron Pharmaceuticals Inc

Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized TRKB locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized TRKB locus express a human TRKB protein or a chimeric transthyretin protein, fragments of which are from human TRKB. Methods are provided for using such non-human animals comprising a humanized TRKB locus to assess in vivo efficacy of human-TRKB-targeting reagents such as nuclease agents designed to target human TRKB.

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15-02-2024 дата публикации

Anti-tfr:payload fusions and methods of use thereof

Номер: US20240052051A1
Принадлежит: Regeneron Pharmaceuticals Inc

Provided, in part, are an anti-human transferrin receptor antigen-binding proteins and fusion proteins comprising an anti-human transferrin receptor antigen-binding proteins (e.g., in scFv, Fab or antibody format) which may be fused to a payload for delivery of the payload to a targeted tissue (e.g., past the blood-brain barrier and to the brain). Payloads include, for example, alpha-glucosidase (GAA) polypeptide. Methods for treating various diseases with such molecules, e.g., glycogen storage diseases, such as Pompe Disease, with the fusions are provided.

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26-10-2023 дата публикации

Anti-tfr:gaa and anti-cd63:gaa insertion for treatment of pompe disease

Номер: US20230338477A1
Принадлежит: Regeneron Pharmaceuticals Inc

Nucleic acid constructs and compositions that allow insertion of a multidomain therapeutic protein (e.g., GAA fusion protein) coding sequence into a target genomic locus such as an endogenous ALB locus and/or expression of the multidomain therapeutic protein (e.g., GAA fusion protein) coding sequence are also provided. The nucleic acid constructs and compositions can be used in methods of integration of a multidomain therapeutic protein (e.g., GAA fusion protein) nucleic acid into a target genomic locus, methods of expression of a multidomain therapeutic protein (e.g., GAA fusion protein) in a cell, methods of reducing glycogen accumulation, methods of treating Pompe disease or GAA deficiency in a subject, and method of preventing or reducing the onset of a sign or symptom of Pompe disease in a subject, including neonatal cells and subjects.

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24-10-2023 дата публикации

Template refined bi-prediction for video coding using anchor point

Номер: US11800088B2
Принадлежит: HULU LLC

In some embodiments, a method performs a first calculation to select an anchor point based on a first reference block in a first reference frame and a second reference block in a second reference frame. The first reference frame is selected as the anchor point. A third reference block in the second reference frame is selected based on the first reference frame being selected as the anchor point. The method performs a second calculation to select the anchor point based on the first reference block in the first reference frame and the third reference block in the second reference frame and determines whether to use the first reference block and the third reference block as a prediction for a current block based on the second calculation.

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17-02-2021 дата публикации

Template refined bi-prediction for video coding

Номер: EP3777176A1
Принадлежит: HULU LLC

In one embodiment, a method selects a first reference block in a first reference frame and a second reference block in a second reference frame. The first reference block and the second reference block are used to predict a current block. The first reference block is selected as an anchor point. Then, the method searches in the second reference frame for a third reference block and determines whether the third reference block is a better reference block than the second reference block for predicting the current block.

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