13-09-2018 дата публикации
Номер: US20180258127A1
Принадлежит:
The present disclosure provides nicotinate/nicotinamide riboside compounds or derivatives of formula (I): 2. A nicotinate/nicotinamide riboside compound or derivative of formula (I) of claim 1 , wherein:{'sup': '−', 'Xis selected from the group consisting of chloride, ascorbate, citrate, phosphate, sulfate, and trifluoromethanesulfonate;'}{'sup': '2', 'Zis oxygen;'}n is 0;{'sup': '1', 'Ris selected from the group consisting of thiamine ester, pterostilbenyl ester, choline ester, vitamin B1 ester, vitamin B2 ester, and vitamin B6 ester;'}{'sup': 2', '3', '4', '5, 'R, R, R, and Rare each hydrogen;'}{'sup': '6', 'Ris selected from the group consisting of hydrogen, —C(O)R′, tryptophan ester, isoleucine ester, alanine ester, phenylalanine ester, valine ester, methionine ester, leucine ester, vitamin B1 ester, vitamin B2 ester, and vitamin B6 ester;'}{'sub': 1', '8, 'R′ is selected from the group consisting of unsubstituted (C-C)alkyl, and substituted or unsubstituted heteroaryl; and'}{'sup': 7', '8, 'Rand Rare independently selected from the group consisting of hydrogen and —C(O)R′.'}3. A nicotinate/nicotinamide riboside compound or derivative of formula (I) of claim 2 , wherein R′ is methyl or nicotinyl.4. A nicotinate/nicotinamide riboside compound or derivative of formula (I) of claim 1 , wherein:{'sup': '−', 'Xis selected from the group consisting of chloride, ascorbate, citrate, phosphate, sulfate, and trifluoromethanesulfonate;'}{'sup': '2', 'Zis NH;'}n is 0;{'sup': '1', 'Ris selected from the group consisting of hydrogen, thiamine ester, pterostilbene ester, choline ester, vitamin B1 ester, vitamin B2 ester, and vitamin B6 ester;'}{'sup': 2', '3', '4', '5, 'R, R, R, and Rare each hydrogen;'}{'sup': '6', 'Ris selected from the group consisting of hydrogen, —C(O)R′, tryptophan ester, isoleucine ester, alanine ester, phenylalanine ester, valine ester, methionine ester, leucine ester, vitamin B1 ester, vitamin B2 ester, and vitamin B6 ester;'}{'sub': 1', '8, 'R′ is ...
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