Fixing element

The invention relates to a fixing element ( 1 ) for anchoring in a drilled hole, having a shank portion ( 2 ) and an expansion element ( 3 ), there being arranged on the shank portion ( 2 ) an expander body ( 8 ) for expanding the expansion element ( 3 ). The expansion element ( 3 ) has a plurality of arcuate expansion lobes ( 11 ), each expansion lobe ( 11 ) being formed by two bridging portions ( 14 ) connected by a yoke ( 15 ). The bridging portions ( 14 ) of the expansion lobes ( 11 ) together generate an envelope surface (M) of the expansion element ( 3 ), which envelope surface (M) has rotational symmetry about the longitudingal axis (A) of the fixing element ( 1 ). In order to provide a fixing element ( 1 ) which can be used both in a wide and also in a narrow drilled hole, the invention proposes that the yoke ( 15 ) have an arcuate curvature ( 17 ) which projects beyond the envelope surface (M) in the radial direction (R).

Optimized probe selection method

The present invention provides methods for optimizing oligonucleotide hybridization probes for use in basic and clinical research. Specifically, the invention involves hybridizing serially diluted genomic sample to the oligonucleotide probes on the array, such that a signal intensity is produced for each of the probes; computationally identifying optimized probes which exhibit signal intensities that correspond to the serial dilutions of genomic sample and are reproducibly strong relative to non-optimized probes.

Chelating molecules

Provided herein are a variety of metal chelators as well as methods of use thereof.

Printable molecular ink

A molecular ink contains a silver carboxylate, an organic amine compound, an organic polymer binder, a surface tension modifier, and a solvent. The ink may be used to produce conductive silver traces on a substrate for use in fabricating electronic devices. The ink is particularly useful for producing conductive silver traces on a shapeable (e.g. stretchable) substrate in a low temperature sintering process. Also, a process for producing a conductive silver trace on a shaped substrate involves depositing the molecular ink on a shapeable substrate, drying the ink on the shapeable substrate to form a non-conductive trace containing the silver carboxylate on the shapeable substrate, forming the shapeable substrate into a shape to produce a shaped substrate so that at least a portion of the non-conductive trace is situated on a shaped portion of the shaped substrate, and sintering the shaped substrate to decompose the silver carboxylate to metallic silver thereby producing a conductive silver trace on at least the shaped portion of the shaped substrate. The process reduces potential for cracking of conductive silver traces on shaped substrates.

METHOD FOR OBTAINING VALUE-DETERMINING CONTENTS FROM FOODS

The invention relates to a method for obtaining value-determining contents, such as flavouring substances, vitamins, and polyphenols, from foods (), having the following steps: a) providing a food (), b) adding a plant oil () as an extractant, c) grinding the food () and the plant oil () into a mash (), and d) separating the mash into an extraction phase, which is an oil phase (), and a solid phase () as a raffinate phase. The food () and the plant oil () are ground very finely, said grinding process being defined in that the food () together with the plant oil () is ground until the oil phase () has an average particle size of less than 300 μm, preferably less than 100 μm, particularly preferably less than 20 μm. 113. A method for obtaining ingredients such as flavouring substances , vitamins and polyphenols from foods () comprising the following steps:{'b': '13', '(a) providing a food (),'}(b) adding an extractant,{'b': 13', '15', '21, '(c) grinding the foodstuff () and the extractant () into a mash (); and'}{'b': 25', '29, '(d) separation into an extraction phase, which is an oil phase (), and a solid phase () as a raffinate phase,'}characterized in that,{'b': 13', '15', '13', '15', '25', '21', '23', '29', '25', '41', '27, 'the food () with the extractant () is finely ground, the ultra-fine grinding being defined in that the food () with the extractant () is ground until the oil phase () has an average particle size of less than 300 μm, preferably of less than 100 μm and particularly preferably of less than 20 μm, and in that the mash () is separated in a three-phase separator () into a solid phase (), an oil phase () for obtaining an essential oil () and an aqueous phase ().'}2. Method according to claim 1 , characterized in that the extractant is a vegetable oil.3. Method according to claim 1 , characterized in that the extractant is a salt solution or a sugar solution.4. Method according to and claim 1 , characterized in that the extractant is a mixture of two ...

Composition for producing a shaped refractory ceramic product, a method for producing a shaped refractory ceramic product, and a shaped refractory ceramic product

The invention relates to a composition (batch) for producing a shaped refractory ceramic product, a method for producing a shaped refractory ceramic product, and a shaped refractory ceramic product.

Functionalized product fabricated from a resin comprising a functional component and a polymeric resin, and method of making the same

Functional and/or functional precursor products, formulations for making the products, methods of making the products (e.g. functional coatings, concentrated gradients, and/or composites), and uses thereof are provided. In an aspect, a method for making a product is provided, the method comprising: a) combining at least one first component and at least one polymerizable component to form a composition; and b) polymerizing the at least one polymerizable component to form at least one polymer, wherein at least two phases are formed from the at least one first component and the at least one polymer. The at least one first component comprises at least one functional component, at least one functional precursor component, or combinations thereof, and the product is a functional product, a functional precursor product, or a combination of a functional and functional precursor product.

Laminate structures and flexible packaging materials incorporating same

Embodiments of the present disclosure are directed to laminates comprising a uniaxially oriented first multilayer film comprising ethylene-based polymer, wherein the uniaxially oriented first multilayer film has a ratio of percent elongation at break in the cross direction to percent elongation at break in the machine direction of at least 2 to 1; and a biaxially oriented second multilayer film adhered to the uniaxially oriented first multilayer film and comprising an ethylene-based polymer, wherein the biaxially oriented second multilayer film has a ratio of percent elongation at break in the machine direction to percent elongation at break in the cross direction of at least 2 to 1.

INORGANIC SALTS OF NICOTINIC ACID MONONUCLEOTIDE AS ANTI-AGING AGENTS

The present invention relates to inorganic salts of nicotinic acid mononucleotides and compositions of Formula I, useful in the treatment of disorders and diseases associated with deficiencies in NAD: 2. The salt of claim 1 , wherein Mis a cation selected from the group consisting of Li claim 1 , Na claim 1 , Rb claim 1 , Cs claim 1 , Be claim 1 , Mg claim 1 , Ca claim 1 , Sr2+ claim 1 , Zn claim 1 , and Ba.3. The salt of claim 1 , wherein Mis Na.4. The salt of claim 1 , wherein Mis K.5. The salt of claim 1 , wherein Mis Li claim 1 ,6. The salt of claim 1 , wherein Mis Rb.7. The salt of claim 1 , wherein Ris H or methyl.8. The salt of claim 1 , wherein Mis selected from the group consisting of Li claim 1 , Na claim 1 , K claim 1 , Rb claim 1 , Cs claim 1 , Be claim 1 , Mg claim 1 , Ca claim 1 , Sr claim 1 , Zn claim 1 , and Ba.9. The salt of claim 8 , wherein Mis Na.10. The salt of claim 8 , wherein Mis K.11. The salt of claim 8 , wherein Mis Li.12. The salt of claim 1 , wherein Ris H.13. The salt of claim 1 , wherein Ris H.20. A pharmaceutical composition comprising a salt and a pharmaceutically acceptable carrier.21. A method of treating or preventing an age-related infertility comprising administering to a subject in need thereof claim 1 , an effective amount of a salt of .22. A method of treating or preventing infertility comprising administering to a subject in need thereof claim 1 , an effective amount of a salt of .23. A method of improving oocyte quality and maturation comprising contacting the oocyte with an effective amount of a salt of prior to implantation into a subject in need of treatment of age-related infertility.24. The method of claim 23 , wherein the oocyte is cultured in an IVF media containing the salt.25. A method of improving blastocyst quality and maturation comprising contacting the blastocyst with an effective amount of a salt of prior to implantation into a subject in need of treatment of age-related infertility.26. The method of claim 25 ...

Anti-sirp alpha antibodies

The present invention relates to antibodies against SIRPα that are suitable for use in anti-cancer therapy. The invention further relates to the use of the anti-SIRPα antibodies in the treatment of human solid tumours and haematological malignancies, optionally in combination with other anti-cancer therapeutics. The anti-SIRPalpha antibodies described are more specific than known anti-SIRPalpha antibodies, whereas they show excellent affinity for both SIRPalpha1 and SIRPalphaBIT. In one embodiment the anti-SIRPalpha antibodies do not bind to SIRPgamma. In a second embodiment, the anti-SIRPalpha antibodies do not bind to SIRPgamma and do not bind to SIRPbeta1v1. In a third embodiment, the anti-SIRPalpha antibodies do not bind to SIRPgamma and do not bind to SIRPeta1v2. In a fourth embodiment, the anti-SIRPalpha antibodies do not bind to SIRPbeta1v1.

Cart for Watercraft

A cart is provided for a watercraft including at least two apertures provided therein. the cart includes a transportation portion, and a carrying portion. The carrying portion includes at least two vertical shafts protruding from the transportation portion. The protruding end of each shaft is connected to, or received within, a watercraft engaging portion that tapers off in size as it extends further away from the transportation portion such that at least a section of each watercraft engaging portion deforms and compresses when received within one of the at least two apertures to create frictional engagement between the aperture and the section of the watercraft engaging portion.

A batch for producing a refractory carbon-bonded brick, a method for producing a refractory carbon-bonded brick and a use of Ti2AlC

The invention relates to a batch composition for producing a carbon-bonded refractory stone, a method for producing a carbon-bonded refractory stone, and use of TiAlC. 1. Batch for producing a refractory carbon-bonded brick , comprising the following components:1.1 a refractory basic component,1.2 a carbon component,{'sub': '2', '1.3 TiAlC.'}2. Batch according to with a proportion of TiAlC in range from 1 to 10% by mass.3. Batch according to claim 1 , in which the refractory basic component comprises one or more magnesia claim 1 , alumina or zirconia-based refractory raw materials.4. Batch according to in which the refractory basic component consists at least 90% by mass of at least one of the oxides MgO claim 1 , AlOor ZrO.5. Batch according to in which the refractory basic component comprises one or more of the following refractory raw materials: sinter magnesia claim 1 , fused magnesia claim 1 , sinter corundum claim 1 , fused corundum claim 1 , tabular alumina claim 1 , magnesia spinel or zirconia.6. Batch according to in which the refractory basic components consists of one or more magnesia claim 1 , alumina or zirconia-based refractor raw materials.7. Batch according to in which the refractory basic component consists of one or more of the following refractory raw materials: sinter magnesia claim 1 , fused magnesia claim 1 , sinter corundum claim 1 , fused corundum claim 1 , tabular alumina claim 1 , magnesia spinel or zirconia.8. Batch according to with a proportion of the refractory basic component in the range from 70 to 97% by mass.9. Batch according to in which the carbon component consists of one or more carriers of free carbon as well as also of one or more coking binding agents.10. Batch according to with carriers of free carbon in the form of one or more of the following raw materials: graphite or soot.11. Batch according to with a proportion of the carbon component in the range from 2 to 29% by mass.12. Method of producing a refractory brick with a ...

Battery disconnecting device

A battery disconnecting device has a first input and a second input to which a battery can be connected, whereby the disconnecting device also has a first output and a second output to which an electric component can be connected, whereby at least one first circuit breaker is arranged between the first input and the first output, and at least one second circuit breaker is arranged between the second input and the second output, whereby the first circuit breaker is at least a transistor and the second circuit breaker is a relay.

Locating a Head Mounted Display in a Vehicle

A head mounted display is configured to determine the posture of the head mounted display relative to a vehicle. The head mounted display includes a display, a camera and an electronic computing unit; and is set up to: create recordings of the environment of the head mounted display with the aid of the camera; receive details relating to the position and/or orientation of a movable object in the interior of the vehicle; detect the image of the object in the recordings from the camera; and determine the posture of the head mounted display taking into account the image of the object in the recordings relative to the vehicle. The posture of the head mounted display indicates the position of the pair of data glasses and the alignment of the pair of data glasses.

COFFEE CHERRY PROCESSING METHODS AND EXTRACTION PRODUCTS OBTAINED BY THE SAME

Described are methods and/or techniques for the production of coffee fruit extracts on the basis of coffee cherries, which enable improved extraction and yield of usable aromatic constituents and nutritionally beneficial components (incl. polyphenols, antioxidants, and/or sugars) of the coffee fruit. Specifically, the invention relates to a coffee cherry processing method, comprising the steps of: (1) adding water to coffee cherries or to any of pulp or green, unroasted coffee beans obtained from the coffee cherries to form a suspension; (2) wet grinding said suspension in multiple steps to an average particle size of 100μηη or less; and (3) subjecting said suspension to one or more separation and/or processing steps comprising at least the separation of the water phase to obtain at least one coffee cherry extract selected from coffee cherry aroma, coffee cherry oil, coffee cherry powder, coffee cherry juice, coffee pulp aroma, coffee pulp powder, coffee pulp juice, coffee aroma and green or roasted coffee powder. 1. A coffee cherry processing method , comprising the steps of:(1) adding water to coffee cherries or to any of pulp or green, un roasted coffee beans obtained from the coffee cherries to form a suspension;(2) wet grinding said suspension in multiple steps to an average particle size of 100μιτι or less; and(3) subjecting said suspension to one or more separation and/or processing steps comprising at least the separation of the water phase to obtain at least one coffee cherry extract selected from coffee cherry aroma, coffee cherry oil, coffee cherry powder, coffee cherry juice, coffee pulp aroma, coffee pulp powder, coffee pulp juice, coffee aroma and green or roasted coffee powder.2. A coffee cherry processing method , comprising the steps of:(1) adding water to coffee cherries to form a suspension:(2) wet grinding said suspension in multiple grinding steps to an average particle size of 100μηη or less; and(3) subjecting said suspension to one or more ...

BATCH FOR PRODUCING A CARBON-BONDED OR RESIN-BONDED SHAPED FIRE-RESISTANT PRODUCT, A METHOD FOR PRODUCING SUCH A PRODUCT, A PRODUCT OF SAID TYPE, AND A USE OF MAGNESIA SPINEL ZIRCONIUM OXIDE

The invention relates to a batch for producing a carbon-bonded or resin-bonded shaped fire-resistant product, a method for producing such a product, a product of said type, and a use of magnesia spinel zirconium oxide. 112-. (canceled)13. A batch comprising:at least one component comprising alumina,at least one component comprising carbon,at least one antioxidant for suppressing oxidation of carbon,at least one component in the form of magnesia spinel-zirconium oxide being present as fused raw material,wherein the batch is usable to produce a resin-bonded or carbon-bonded shaped refractory product.14. The batch according towherein the magnesia spinel-zirconium oxide is present in the batch in a range from 2% to 35% by weight.15. The batch according towherein the magnesia spinel of the magnesia spinel-zirconium oxide is present in a stoichiometric quantity.16. The batch according towherein a proportion of zirconium oxide in the magnesia spinel-zirconium oxide is from 10% to 65% by weight.17. The batch according towherein the magnesia spinel-zirconium oxide has a grain size that does not exceed 3.0 mm.18. The batch according towherein the at least one component comprising alumina is present in the batch in a range from 60% to 90% by weight.19. The batch according towherein the at least one component comprising carbon is present in the batch in a range from 2% to 9% by weight.20. The batch according to metallic silicon,', 'metallic aluminum, or', 'boron carbide., 'wherein the at least one antioxidant includes at least one of'}21. The batch according towherein the batch is usable to produce at least one of a carbon-bonded or resin-bonded slide plate for a steel strand casting system.22. A process comprising:(a) providing a batch including:at least one component comprising alumina,at least one component comprising carbon,at least one antioxidant for suppressing oxidation of carbon,at least one component in the form of magnesia spinel-zirconium oxide being present as ...

Storage stable mixtures, method of improving retention of a compound and use of rice hulls and/or rice bran to enhance retention of a compound

The present invention relates to improved formulations of propandiol mononitrate and derivatives thereof as well as to the production of such formulations.

METHOD FOR THE TREATMENT OF MAGNESIA-CARBON PRODUCTS

The invention relates to a method for treating magnesia-carbon products. 1. A method for the treatment of magnesia-carbon products , comprising the following method steps: A.1 the magnesia-carbon products comprise magnesia and carbon;', {'sub': 4', '3, 'A.2 the magnesia-carbon products comprise proportions of AlC;'}], 'A. providing magnesia-carbon products comprising the following featuresB. providing water; C.1 the gas comprises carbon dioxide;', 'C.2 the proportion of carbon dioxide in the gas is above the proportion of carbon dioxide in the air;, 'C. providing a gas comprising the following featuresD. providing a container that encloses a space;E. providing the magnesia carbon products in the space; F.1 temperature; and', 'F.2 pressure', 'while providing the water and the gas in the space., 'F. subjecting the space to'}2. The method of claim 1 , wherein the magnesia-carbon products are used magnesia-carbon products.3. The method according to claim 1 , wherein the magnesia-carbon products and the water are provided in the space in such proportions that in the space the molar ratio of water to AlCis at least 8 to 1.4. The method according to claim 1 , wherein the gas and the water are provided in such proportions in the space that in the space the molar ratio of carbon dioxide to water is at least 1 to 1.5. The method according to claim 1 , wherein the space is subjected to temperature in the range of 100 to 320° C.6. The method according to claim 1 , wherein the space is subjected to pressure in the range of 0.1 to 6 MPa.7. The method according to claim 1 , wherein the gas is carbon dioxide gas.8. The method according to claim 1 , wherein the space enclosed by the container is sealed gas-tight after providing the magnesia-carbon products in the space.9. The method according to claim 1 , wherein the container is an autoclave.10. The method according to claim 1 , wherein the magnesia-carbon products comprise an AlCcontent of at least 0.1% by mass claim 1 , based on ...

Hearing device with a battery drawer

The present disclosure relates to hearing devices having a battery drawer. The present disclosure further relates to hearing devices having a battery drawer for a rechargeable battery or at least the capability to hold a rechargeable battery, however, other types of batteries may also be stored in the battery drawer.

COMPOSITIONS OF NRF2 INHIBITING AGENTS AND METHODS OF USE THEREOF

Among the various aspects of the present disclosure is the provision of compositions of NRF2 inhibiting agents and methods of use thereof. These agents can be useful for cancer treatment, including as radiosensitizing agents and as chemotherapeutic sensitizing agents. 2. The compound of claim 1 , wherein Ris selected from the group consisting of H or halogen.3. The compound of claim 1 , wherein Ris selected from the group consisting of H claim 1 , halogen claim 1 , and Ccycloalkyl.4. The compound of claim 1 , wherein Rand Rare linked with Calkyl.5. The compound of claim 1 , wherein Ris selected from the group consisting of H claim 1 , halogen claim 1 , halo-substituted Calkyl claim 1 , Ccycloalkyl-substituted sulfonyl claim 1 , halo-substituted bi-Ccycloalkyl claim 1 , hetro-bi-cyclo-alkyl-substituted sulfonyl or bi-cyclo-alkyl-substituted sulfonyl claim 1 , and bi-hetrocyclyl.6. The compound of claim 6 , wherein Ris H claim 6 , Cl claim 6 , cyclopentylsulfonyl claim 6 , azaspiro[3.3]heptan-6-yl)sulfonyl claim 6 , bicyclo[3.1.0]hexan-3-ylsulfonyl claim 6 , 3-fluorobicyclo[1.1.1]pentan-1-yl claim 6 , or azabicyclo[3.1.0]hexan-3-yl.7. The compound of claim 1 , wherein Ris selected from the group consisting of H claim 1 , halogen claim 1 , halo-substituted Calkyl claim 1 , Calkylsulfonyl claim 1 , and Cheterocyclyl.8. The compound of claim 7 , wherein Ris H claim 7 , Cl claim 7 , trifluoromethyl claim 7 , methylsulfonyl claim 7 , pyrrolidin-1-yl claim 7 , or morpholino.9. The compound of claim 1 , wherein Ris selected from the group consisting of H and halogen.10. The compound of claim 1 , wherein Ris selected from the group consisting of H claim 1 , aminoCalkyl claim 1 , Calkyl claim 1 , Calkoxy-substituted Calkyl claim 1 , oxy-substituted Calkyl claim 1 , Ccycloalkyl-substituted Calkyl claim 1 , carboxyl-substituted Calkyl claim 1 , heterocyclyl-substituted Calkyl claim 1 , carboxyl-substituted- or heterocyclyl-substituted-Calkyl claim 1 , and carboxyl-substituted- ...

A vacuum lifting device

A vacuum lifting device to facilitate the lifting and/or repositioning of an article having an external surface as set out herein comprises at least one pair of handles and a base having opposed first and second surfaces, the base having an aperture arranged through the base. The second surface is arranged is provided with a continuous sealing joint projecting downwards from the second surface defining an enclosed area which includes the aperture on the bottom surface of the base. The vacuum lifting device also comprises a suction conduit arranged to be connected to a vacuum generating member and configured to be in fluid connection with the second surface of the base through the aperture. The vacuum lifting device further comprises an extendable lifting member arranged between the at least one pair of handles and the first surface of the base, the lifting member is actuated by a lift actuating member for shifting the base in a vertical direction transferring said vacuum lifting device ( 10 ) between an extended and a compressed state. A method for using the vacuum lifting device is also disclosed.

Conductive paste, electrode and solar cell

The present invention relates to a conductive paste for forming a conductive track or coating on a substrate, particularly suitable for use in solar cells. The paste comprises a solids portion dispersed in an organic medium, the solids portion comprising electrically conductive material and an inorganic particle mixture wherein the inorganic particle mixture comprises substantially crystalline particles. The present invention also relates to a method of preparing a conductive paste, a method for the manufacture of a surface electrode of a solar cell, an electrode for a solar cell and a solar cell.

TENSIONING DEVICE FOR A TRACTION DRIVE

A tensioning device for a traction drive comprises: a base body, a tensioning arm pivotably mounted about a pivot axis relative to the base body by a radial bearing, wherein one of the base body and tensioning arm has an annular carrier portion axially supported relative to the other of the tensioning arm and base body by a first axial bearing in a first direction and by a second axial bearing in a second direction, a first sealing element connected to said support portion for sealing said first axial bearing, a second sealing element connected to said support portion for sealing said second axial bearing, wherein the first and second axial bearings are made of a different material than the first and second sealing elements, spring means via which the tensioning arm is supported in the circumferential direction against the base body, and a tensioning roller which is rotatably mounted on the tensioning arm and serves to tension a traction means, wherein the first sealing element and the second sealing element are connected to one another by a plurality of connecting webs that extend through bores in the carrier portion. 114.-. (canceled)15. A tensioning device for a traction drive comprising:a base body,a tensioning arm which is pivotably mounted about a pivot axis relative to the base body by a radial bearing,wherein one of the base body and tensioning arm has an annular carrier portion which is axially supported relative to the other one of the tensioning arm and base body by a first axial bearing in a first direction and by a second axial bearing in a second direction,a first sealing element connected to said carrier portion for sealing said first axial bearing,a second sealing element connected to said carrier portion for sealing said second axial bearing,wherein the first and second axial bearings are made of a different material than the first and second sealing elements,at least one spring by which the tensioning arm is supported in a circumferential direction ...

AMINO ACID SALTS OF NICOTINIC ACID RIBOSIDES AS ANTI-AGING AGENTS

The present invention relates to amino acid salts of nicotinic acid ribosides and compositions thereof of Formula I, useful in the treatment of disorders and diseases associated with deficiencies in NAD: 2. The salt of claim 1 , wherein Ris H.3. The salt of claim 1 , wherein Ris methyl.5. The salt of any one of to claim 1 , wherein Ris H.6. The salt of any one of to claim 1 , wherein Ris H.7. The salt of any one of to claim 1 , wherein Ris H.8. The salt of any one of to claim 1 , wherein Ris C-Calkyl claim 1 , (C-Calkylene)C-Caryl claim 1 , or (C-Calkylene)heteroaryl claim 1 , or C-Calkyl substituted with one or more (C-Calkylene)SR.91. The salt of claim 8 , wherein Ris C-hd -l -Calkyl.11. The salt of any one of to claim 8 , wherein Ris H.12. The salt of any one of to claim 8 , wherein Ris C(O)C-Calkyl.13. The salt of any one of to claim 8 , wherein Ris C-Calkyl.14. The salt of any one of to claim 8 , wherein Ris H.15. The salt of any one of to claim 8 , wherein Ris C(O)C-Calkyl.16. The salt of any one of to claim 8 , wherein Ris C-Calkyl.17. The salt of selected from the group consisting of:(S)-2-Ammonio-3-phenylpropanoate compound with 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridine-1-ium-3-carboxylate (1:1) (I-001);(2S,3S)-2-Ammonio-3-methylpentanoate compound with 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridine-1-ium-3-carboxylate (1:1) (I-002);(S)-2-Ammonio-3-(1H-indol-3-yl)propanoate compound with 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridine-1-ium-3-carboxylate (1:1) (I-003);1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium-3-carboxylate-(S)-6-amino-2-ammoniohexanoate (1:1) (I-004);1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium-3-carboxylate (S)-5-amino-2-ammonio-5-oxopentanoate (1:1) (I-005);1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium-3-carboxylate-(S)-2-ammonio ...

USE OF PIRFENIDONE AND DERIVATIVES FOR MODULATION OF B LYMPHOCYTE ACTIVITY AND ORGAN PROTECTION FROM ACUTE TISSUE DAMAGE

The present disclosure relates to compositions and methods of modulating B lymphocyte activity, and organ protection after acute injury. In particular, PEG-Pirfenidone has increased half-life, improved bioavailability and is equipotent in modulating B cell activity and is particularly useful as protective agents from acute organ damage and disease caused by dysregulation of B cell activity. 2. The compound of claim 1 , wherein the PEG or mPEG has a molecular weight ranging from about 100 to about 50 claim 1 ,000 Daltons claim 1 , about 200 to about 50 claim 1 ,000 Daltons claim 1 , about 300 to about 50 claim 1 ,000 Daltons claim 1 , about 400 to about 50 claim 1 ,000 Daltons claim 1 , about 500 to about 50 claim 1 ,000 Daltons claim 1 , about 600 to about 50 claim 1 ,000 Daltons claim 1 , about 700 to about 50 claim 1 ,000 Daltons claim 1 , about 800 to about 50 claim 1 ,000 Daltons claim 1 , about 900 to about 50 claim 1 ,000 Daltons claim 1 , from about 1 claim 1 ,000 to about 50 claim 1 ,000 Daltons claim 1 , from about 1 claim 1 ,500 to about 50 claim 1 ,000 claim 1 , from about 2 claim 1 ,000 to about 50 claim 1 ,000 claim 1 , from about 2 claim 1 ,500 to about 50 claim 1 ,000 claim 1 , from about 3 claim 1 ,000 to about 50 claim 1 ,000 claim 1 , from about 3 claim 1 ,500 to about 50 claim 1 ,000 claim 1 , from about 4 claim 1 ,000 to about 50 claim 1 ,000 claim 1 , from about 4 claim 1 ,500 to about 50 claim 1 ,000 claim 1 , from about 5 claim 1 ,000 to about 50 claim 1 ,000 claim 1 , from about 5 claim 1 ,500 to about 50 claim 1 ,000 claim 1 , from about 6 claim 1 ,000 to about 50 claim 1 ,000 claim 1 , from about 6 claim 1 ,500 to about 50 claim 1 ,000 claim 1 , from about 7 claim 1 ,000 to about 50 claim 1 ,000 claim 1 , from about 7 claim 1 ,500 to about 50 claim 1 ,000 claim 1 , from about 8 claim 1 ,000 to about 50 claim 1 ,000 claim 1 , from about 8 claim 1 ,500 to about 50 claim 1 ,000 claim 1 , from about 9 claim 1 ,000 to about 50 claim 1 ,000 claim ...

FIRE-RESISTANT CERAMIC PRODUCT

The invention relates to a fire-resistant ceramic product. 1. A refractory ceramic product whose microstructure has the following features:a matrix composed of at least one first material;grains of at least one second material are embedded in the matrix;the grains of the second material have a coating composed of at least one third material on at least part of their surface;the first and second material have a different coefficient of thermal expansion;the third material is stable during use of the product.2. The product as claimed in in the form of a sintered product.3. The product as claimed in claim 1 , wherein the first material is based on one or more of the following oxides or compounds: MgO claim 1 , AlO claim 1 , FeO claim 1 , SiO claim 1 , CaO claim 1 , CrO claim 1 , ZrO claim 1 , MnO claim 1 , TiOor one or more of the compounds magnesia spinel claim 1 , hercynite claim 1 , galaxite or forsterite.4. The product as claimed in claim 1 , wherein the second material is based on one or more of the following oxides or compounds thereof: AlO claim 1 , MgO claim 1 , SiOor ZrO.5. The product as claimed in claim 1 , wherein the third material is based on at least one of the following materials: gahnite claim 1 , magnesia spinel claim 1 , forsterite claim 1 , mullite claim 1 , calcium zirconate or ABO(where A=Al claim 1 , Cr or Fe and B=Mg claim 1 , Zn claim 1 , Fe claim 1 , Mn or Ni).6. The product as claimed in claim 1 , wherein the thickness of the coating is in the range from 5 to 300 μm.7. The product as claimed in claim 1 , wherein the first material is in the form of grains sintered to one another.8. The product as claimed in claim 1 , wherein the coefficient of thermal expansion of the second material is at least 10% greater or less than the coefficient of thermal expansion of the first material claim 1 , based on the coefficient of thermal expansion of the first material.9. The product as claimed in claim 1 , wherein the particle size of the grains of the ...

Pyrazole carboxamide compounds and methods of use

Pyrazole carboxamide compounds of Formula I are provided, with various substituents, and including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk, and for treating cancer and immune disorders such as inflammation mediated by Btk. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Piercing device for an administration device

A piercing device for an administration device includes an elastic element with which a biasing force may be generated for piercing, a base, and a cannula unit which may be movable relative to the base in a piercing direction from a safety (secured) position, where the cannula unit may be subjected to the biasing force in the piercing direction. The administration device further includes a securing element by which the cannula unit, subjected to the biasing force, may be held in the safety position and which has a thermosensitive region that may be deformable under mechanical stress when heated, and a heating element with which the thermosensitive region of the securing element may be heated, such that the thermosensitive region of the securing element may deform in response to the biasing force and, as a result, the cannula unit may move away from the safety position in the piercing direction.

INORGANIC SALTS OF NICOTINAMIDE MONONUCLOETIDE AS ANTI-AGING AGENTS

The present invention relates to inorganic salts of nicotinamide mononucleotides and compositions of Formula I, useful in the treatment of disorders and diseases associated with deficiencies in NAD: 2. The salt of claim 1 , wherein Mis a cation selected from the group consisting of Li claim 1 , K claim 1 , Rb claim 1 , Cs claim 1 , Be claim 1 , Mg claim 1 , Ca claim 1 , Sr claim 1 , Zn claim 1 , and Ba.3. The salt of any one of to claim 1 , wherein Mis K.4. The salt of any one of to claim 1 , wherein Mis Li.5. The salt of any one of to claim 1 , wherein Mis Rb.6. The salt of any one of to claim 1 , wherein Ris H.7. The salt of any one of to claim 1 , wherein Ris C-Calkyl.8. The salt of any one of to claim 1 , wherein Ris H.9. The salt of any one of to claim 1 , wherein Ris C-Calkyl.11. A pharmaceutical composition comprising a salt of any one of to and a pharmaceutically acceptable carrier.16. The method of or where the oocyte or blastocyst is cultured in an IVF media containing the salt.21. The process of claim 20 , wherein the metal-alkali hydroxide is added dropwise into a solution of the compound of Formula II.23. The cell culture medium of claim 22 , wherein the culturing agent is an inorganic salt claim 22 , an energy substrate claim 22 , an amino acid claim 22 , a chelator claim 22 , a pH indicator claim 22 , an antibiotic claim 22 , a serum claim 22 , a vitamin claim 22 , a growth factor claim 22 , or any combination thereof.24. The cell culture medium of claim 23 , wherein the inorganic salt is calcium chloride claim 23 , magnesium chloride claim 23 , magnesium sulfate claim 23 , potassium chloride claim 23 , sodium bicarbonate claim 23 , sodium chloride claim 23 , monosodium phosphate claim 23 , disodium phosphate claim 23 , or any combination thereof.25. The cell culture medium of claim 23 , wherein the energy substrate is glucose claim 23 , pyruvate claim 23 , lactate claim 23 , pyruvate claim 23 , or any combination thereof.26. The cell culture medium ...

COCOA BEAN PROCESSING METHODS AND TECHNIQUES

Improved methods and/or techniques for processing and/or extracting materials from cocoa beans. In certain embodiments, cocoa bean processing methods (e.g., using unfermented or fermented or roasted or non-roasted beans) which result in cocoa products with improved taste characteristics and/or increased levels of anti-oxidants and/or vitamins. 1. A method for processing cocoa beans comprising:adding water to a plurality of cocoa beans to form a suspension;wet grinding said cocoa bean water suspension in a first grinding step in a first mill;wet grinding said cocoa bean water suspension in a second grinding step in a second mill;heating said cocoa bean water suspension to a temperature of approximately 70 degrees Celsius or less;decanting said cocoa bean water suspension such that said suspension is separated into three phases, a water phase, a fat phase, and solids.2. A method for processing cocoa beans comprising:adding water to a plurality of cocoa beans to form a cocoa bean/water mixture;fine grinding the cocoa bean/water mixture;heating the finely ground cocoa bean/water mixture to a temperature of approximately 70 degrees Celsius or less to obtain a cocoa bean mixture/suspension;decanting the cocoa bean mixture/suspension to separate larger solids from liquid;separating smaller and/or fine solid particles from liquids and/or separating oil products from non-oil products.3. The method according to further drying said larger solids and/or said smaller and/or fine solid particles in a dryer after separation in said decanting to obtain aromatics and cocoa solids.4. (canceled)5. (canceled)6. (canceled)7. (canceled)8. (canceled)9. (canceled)10. The method according to wherein cocoa butter is produced and when said cocoa butter exits said decanting claim 2 , and said cocoa butter is caused to exit at a temperature selected from between approximately 45 and 50 degrees Celsius.11. The method according to wherein cocoa powder is produced which is dried at a temperature ...

REFRACTORY BATCH, A METHOD FOR PRODUCING AN UNSHAPED REFRACTORY CERAMIC PRODUCT FROM THE BATCH AND AN UNSHAPED REFRACTORY CERAMIC PRODUCT OBTAINED BY THE METHOD

The invention relates to a refractory batch, to a method for producing an unshaped refractory ceramic product from the batch, and to an unshaped refractory ceramic product obtained by said method. 1. Refractory batch comprising the following components:1.1 a basic component comprising one or more raw materials based on magnesia;1.2 a carbon component comprising one or more carbon carriers;1.3 an aluminum component comprising one or more metallic aluminum carriers;1.4 an aqueous binder; and1.5 one or more sulfates with a solubility of at least 15 g per 100 g of water.2. The batch according to claim 1 , wherein the sulfates are one or more of the following sulfates: sodium sulfate claim 1 , iron sulfate claim 1 , lithium sulfate claim 1 , magnesium sulfate or aluminum sulfate.3. The batch according to claim 1 , wherein the basic component consists of at least 90% by mass of magnesia.4. The batch according to claim 1 , wherein the basic component consists of one or more of the following raw materials based on magnesia: sintered magnesia or fused magnesia.5. The batch according to claim 1 , wherein the basic component is present in a proportion of at least 75% by mass.6. The batch according to claim 1 , wherein the aluminum component consists of one or more of the following carriers of metallic aluminum: metallic aluminum or at least one metal alloy comprising aluminum.7. The batch according to claim 1 , wherein the one or more sulfates are present in a proportion in the range from 0.05 to 1.0% by mass.8. The batch according to claim 1 , wherein the aqueous binder is present in a proportion in the range from 4.0 to 15.0% by mass.9. Method for producing an unshaped refractory ceramic product claim 1 , comprising the following steps: a basic component comprising one or more raw materials based on magnesia;', 'a carbon component comprising one or more carbon carriers;', 'an aluminum component comprising one or more metallic aluminum carriers;', 'an aqueous binder; and', ' ...

BLEND FOR THE PRODUCTION OF A REFRACTORY MATERIAL, A REFRACTORY MATERIAL, A METHOD FOR THE MANUFACTURE OF A REFRACTORY MATERIAL, AND USE OF A SUBSTANCE AS A SINTERING AID

The invention relates to a blend for the production of a sintered refractory material containing chromium oxide, a sintered refractory material containing chromium oxide, a method for the manufacture of a sintered refractory material containing chromium oxide and to a use of magnesium titanate. 1. A blend for the production of a refractory material containing sintered chromium oxide , comprising the following components:1.1 at least 20% by weight of chromium oxide;1.2 magnesium titanate;1.3 optionally, other components.2. The blend as claimed in claim 1 , with a chromium oxide content of at least 80% by weight.3. The blend as claimed in claim 1 , with a magnesium titanate content of at most 20% by weight.4. A refractory material containing sintered chromium oxide claim 1 , obtained by firing a blend as claimed in .5. A refractory material comprising:5.1 sintered chromium oxide;5.2 magnesium chromite;5.3 titanium dioxide;5.4 optionally, other components.6. A method for the manufacture of a refractory material containing sintered chromium oxide claim 1 , having the following steps:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, '6.1 providing a blend as claimed in ;'}6.2 firing the blend to form a refractory material.7. A method comprising: using magnesium titanate as a sintering aid to support sintering of chromium oxide when firing blends comprising chromium oxide. The invention relates to a blend for the production of a sintered refractory material containing chromium oxide, a sintered refractory material containing chromium oxide, a method for the manufacture of a sintered refractory material containing chromium oxide and to a use of magnesium titanate.The term “refractory material” in the context of the invention in particular indicates ceramic products with a service temperature of more than 600° C., preferably refractory materials complying with DIN 51060, i.e. materials with a pyrometric core equivalent of more than SK17.Refractory materials are known in the ...

BATCH FOR PRODUCING A REFRACTORY PRODUCT, METHOD FOR PRODUCING A REFRACTORY PRODUCT, A REFRACTORY PRODUCT AND THE USE OF A SYNTHETIC RAW MATERIAL

The invention relates to a batch composition for producing a refractory product, a method for producing a refractory product, a refractory product, and to the use of a synthetic raw material. 1. A batch for producing a refractory product comprising the following components:{'b': 1', '1, '. a base component of at least one refractory ceramic raw material; and'}{'b': 1', '2, 'claim-text': [{'b': 1', '2', '1, 'claim-text': [{'b': 1', '2', '1', '1, '... the bodies consist of grains of at least one refractory ceramic raw material sintered together,'}, {'b': 1', '2', '1', '2, '.... the bodies having a proportion of clay minerals of less than 10% by mass relative to the total mass of the bodies;'}], '.. the synthetic raw material consists of bodies, the bodies having the following features, {'b': 1', '2', '2, '... the bodies have a ratio of (thickness):(width):(length) of (1):(≥1 and ≤length):(≥3)'}], '. at least one synthetic raw material with the following features2. Batch according to claim 1 , wherein the bodies comprise grains of at least one of the following refractory ceramic raw materials sintered together: magnesia claim 1 , spinel claim 1 , corundum claim 1 , zirconia claim 1 , forsterite claim 1 , chromium ore claim 1 , zirconia corundum claim 1 , zirconmullite claim 1 , aluminum titanate claim 1 , magnesium titanate or calcium titanate.3. Batch according to claim 1 , wherein the bodies have a length in the range of 1 to 30 mm.4. Batch according to claim 1 , wherein the at least one refractory ceramic raw material of the base component is present in the form of grains and wherein the bodies have a length which corresponds at least to the length of the average grain diameter of the largest grains of the base component.5. Batch according to claim 1 , wherein the bodies are present in a volume in the range of 0.5 to 30% by volume in the batch claim 1 , relative to the total volume of the batch.6. Batch according to claim 1 , wherein the base component is present in ...

Method for Determining a Viewing Direction of a Person

A method for determining a viewing direction of a person, such as a driver in a motor vehicle, is provided. The method includes detecting a surface contour of a surface of an eye of the person, ascertaining a normal vector on the surface of the eye depending on the detected surface contour, and determining the viewing direction of the person depending on the normal vector.

Preform for an Optical Waveguide and A Fiber with Non-Circular Core

Preform for an optical waveguide containing a core with a non-circular geometry and at least one cladding layer, in which the dopand concentration of the cladding layer is increased compared to the dopand concentration of a preform with circular core geometry and identical NA. A method for the production of a preform for an optical fiber is provided. An optical waveguide with a nominal dopand concentration of c(eff) x F≦c(nom) in at least one cladding layer is also provided.

Fused raw material for the production of a refractory product, a method for the production of the fused raw material and a use of the fused raw material

The invention concerns a fused raw material for the production of a refractory product, a method for the production of the fused raw material and a use of the fused raw material.

Method for Producing Optoelectronic Semiconductor Components and Optoelectronic Semiconductor Component

A method for producing optoelectronic semiconductor components and an optoelectronic semiconductor component are disclosed. In an embodiment the method includes: A) creating a blank by pultrusion from a glass melt, B) shaping the blank into a billet-shaped optical element with a longitudinal axis, the optical element having a mounting side and a light outlet side, C) producing conductor tracks on the mounting side, D) mounting a plurality of optoelectronic semiconductor chips on the mounting side of the optical element and connecting them to the conductor tracks and E) separating the optical element into the optoelectronic semiconductor components, wherein each optoelectronic semiconductor component comprises at least two of the semiconductor chips, and wherein at least steps A) to D) are performed in the stated sequence.

Production of metal-organic frameworks

An apparatus for producing metal organic frameworks, comprising: a tubular flow reactor comprising a tubular body into which, in use, precursor compounds which form the metal organic framework are fed and flow, said tubular body including at least one annular loop.

Compositions and methods for inhibiting arginase activity

The disclosure relates to a novel class of compounds that exhibit activity inhibitory activity toward arginase, and pharmaceutical compositions comprising the compounds of the disclosure. Also provided herein are methods of treating cancer with the arginase inhibitors of the disclosure.

INORGANIC SALTS OF NICOTINIC ACID MONONUCLEOTIDE AS ANTI-AGING AGENTS

The present invention relates to inorganic salts of nicotinic acid mononucleotides and compositions of Formula I, useful in the treatment of disorders and diseases associated with deficiencies in NAD: 2. The salt of claim 1 , wherein Mis selected from the group consisting of Li claim 1 , Na claim 1 , K claim 1 , Rb claim 1 , Cs claim 1 , Be claim 1 , Mg claim 1 , Ca claim 1 , Sr claim 1 , Zn claim 1 , and Ba.3. The salt of claim 1 , wherein Mis Na.4. The salt of claim 1 , wherein Mis K.5. The salt of claim 1 , wherein Mis Li claim 1 ,6. The salt of claim 1 , wherein Mis Rb.7. The salt of claim 1 , wherein Ris H.8. The salt of claim 1 , wherein Mis selected from the group consisting of Li claim 1 , Na claim 1 , K claim 1 , Rb claim 1 , Cs claim 1 , Be claim 1 , Mg claim 1 , Ca claim 1 , Sr claim 1 , Zn claim 1 , and Ba.9. The salt of claim 8 , wherein Mis Na.10. The salt of claim 8 , wherein Mis K.11. The salt of claim 8 , wherein Mis Li.12. The salt of claim 1 , wherein Ris H.13. The salt of claim 1 , wherein Ris H.1617-. (canceled)19. (canceled)20. A pharmaceutical composition comprising a salt and a pharmaceutically acceptable carrier.2130-. (canceled) This application is a continuation application of International Application No.: PCT/US2019/022555, filed on Mar. 15, 2019, which claims priority to, and the benefit of, U.S. Provisional Application No. 62/671,807, filed on May 15, 2018, the contents of which are incorporated herein by reference in their entireties.The present invention relates to inorganic salts of nicotinic acid mononucleotides and compositions thereof useful in the treatment of disorders and diseases associated with aging.Aging is the result of complex interactions involving biological, physical, and biochemical processes that cause dysfunctions in cells and organs which manifests in a variety of diseases and other outcomes. For example, female fecundity is markedly sensitive to the effects of ageing. For example, the USA Centers for Disease ...

Serine protease variants and polynucleotides encoding same

The present invention relates to protease variants, having improved properties compared to the parent protease, in particular variants of a serine protease belonging to family 53 derived from a strain of Meripilus giganteus . The variants according to the invention have in particular increased thermo-stability, e.g., increased residual activity after 30 min at a temperature in the range from 55 to 60° C. and/or increased thermal denaturation temperature, compared to the parent Meripilus giganteus protease. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.

Storage stable mixtures

The present invention relates to improved formulations of propandiol mononitrate and derivatives thereof as well as to the production of such formulations.

METHODS AND COMPOSITIONS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH CANCER, INFLAMMATION, OR IMMUNE RESPONSE

Among the various aspects of the present disclosure is the provision of composition comprising itaconate, malonate, n or a derivative thereof and uses thereof. The present disclosure provides for methods of treating Ikb-ζ associated disease, disorder, or conditions comprising administering a therapeutically effective amount of an itaconate, malonate, or a derivative thereof to a subject. In some embodiments, the therapeutically effective amount reduces or prevents tumor growth, inflammation, or an immune response. Another aspect of the present disclosure includes a method to suppress Ikb-ζ induction comprising administering an itaconate, malonate, or a derivative thereof. 1. A method of treatment of a disease , disorder , or condition associated with an inflammatory response or an immune response comprising:administering a therapeutically effective amount of a composition comprising itaconate, malonate, or a derivative thereof to a subject in need thereof; wherein, the therapeutically effective amount reduces or prevents inflammation or an immune response.2. The method of claim 1 , wherein the immune response is a lipopolysaccharide (LPS)-mediated immune response.3. The method of claim 1 , wherein reducing or preventing inflammation or an immune response results in reduced tissue injury during a cardiovascular infarction.4. The method of claim 1 , wherein the disease claim 1 , disorder or condition is associated with Ikb-ζ or a cancer.5. The method of claim 4 , wherein administration of itaconate claim 4 , malonate claim 4 , or a derivative thereof inhibits tumor growth.6. (canceled)7. The method of claim 1 , wherein the itaconate claim 1 , malonate claim 1 , or a derivative thereof is selected from one or more of the group consisting of: itaconate claim 1 , itaconic acid claim 1 , dimethyl itaconate (DI) claim 1 , 4-methyl itaconate claim 1 , 3-(ethoxycarbonyl)but-3-enoic acid claim 1 , 4-ethoxy-2-methylene-4-oxobutanoic acid claim 1 , 4-octyl itaconate claim 1 , ...

Multilayer films comprising polyethylene and barrier layers and methods of producing the same

Embodiments of multilayer films are disclosed comprising a first layer comprising polyethylene, a second layer comprising a first medium density polyethylene; a barrier layer; a third layer comprising a second medium density polyethylene; and a fourth layer comprising polyethylene. The second layer may be positioned between the first layer and the barrier layer. The barrier layer may be positioned between the second layer and the third layer.

Polypeptide variants

The present invention relates to polypeptide variants and methods for obtaining variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.

Post-model filtering of predictive text

In non-limiting examples of the present disclosure, systems, methods and devices for filtering predictive text surfacing candidates are provided. A predictive text filtering model may be maintained. The predictive text filtering model may comprise a plurality of terms that are associated in the predictive text filtering model with a precarious classification, and a range of a number of words for filtering cooccurrences of precarious and other precarious or blocklist terms from the plurality of terms. A text input may be processed with a predictive text model. A plurality of surfacing candidates may be determined based on the processing of the text input with the predictive text model. The predictive text filtering model may be applied to a surfacing candidate of the plurality of candidates. The surfacing candidate may be filtered from further processing. At least one non-filtered surfacing candidate may be displayed.

Process for undertaking buildings

A process is disclosed for underpinning buildings. At least one elongated supporting element (5) is arranged below the building (1) that needs to be underpinned in a substantially parallel direction to a foundation (2) of the building (1). A whole side wall of the building (1) may thus be underpinned in a single operation without unnecessarily weakening the existing underground. By mutually coupling a plurality of elongated supporting elements (5), a kind of large-surface foundation that securely supports the building (1) can be created. The architectonic substance of very old buildings may thus be preserved in a non-aggressive manner. In addition, the process can be carried out very quickly and at a relatively low cost.

Building underpinning process

A process is disclosed for underpinning buildings. At least one elongated supporting element (5) is arranged below the building (1) that needs to be underpinned in a substantially parallel direction to a foundation (2) of the building (1). A whole side wall of the building (1) may thus be underpinned in a single operation without unnecessarily weakening the existing underground. By mutually coupling a plurality of elongated supporting elements (5), a kind of large-surface foundation that securely supports the building (1) can be created. The architectonic substance of very old buildings may thus be preserved in a non-aggressive manner. In addition, the process can be carried out very quickly and at a relatively low cost.

Building underpinning process

Method for underpinning buildings

The invented method for underpinning buildings (1) comprises arranging at least one elongated supporting element (5), preferably a post, substantially parallel to the foundation (2) of a building (1) in a bore (9) performed in advance below the respective building (1) foundation (2).

Process for casting building works

PROCEDURE TO SHOW BUILDINGS.

LA INVENCION SE REFIERE A UN PROCESO PARA APUNTALADO DE OBRAS, DONDE UN ELEMENTO (5) DE SOPORTE ALARGADO ESTA DISPUESTO AL MENOS POR DEBAJO DE LA OBRA (1), QUE NECESITA SER APUNTALADA EN UNA DIRECCION SUSTANCIALMENTE PARALELA CON RESPECTO AL FUNDAMENTO (2) DE LA OBRA (1). UNA PARED LATERAL COMPLETA DE LA OBRA (1) PUEDE SER APUNTALADA EN UNA OPERACION INDIVIDUAL SIN DEBILITAMIENTO NECESARIO DE LA BASE EXISTENTE. MEDIANTE ACOPLAMIENTO MUTUO DE UNA PLURALIDAD DE ELEMENTOS (5) DE SOPORTE ALARGADOS, PUEDE SER CREADO UN TIPO DE FUNDACION DE LARGA SUPERFICIE QUE SOPORTA DE MANERA SEGURA LA OBRA (1). LA SUSTANCIA ARQUITECTONICA DE EDIFICIOS MUY VIEJOS PUEDE SER DE ESTA FORMA PRESERVADA EN UNA MANERA NO AGRESIVA. ADICIONALMENTE EL PROCESO PUEDE SER REALIZADO DE FORMA MUY RAPIDA Y RELATIVAMENTE CON BAJO COSTE. THE INVENTION REFERS TO A PROCESS FOR SHARPENING OF WORKS, WHERE AN ELEMENTED SUPPORT ELEMENT (5) IS WILLING AT LEAST UNDER THE WORK (1), WHICH NEEDS TO BE SIGNED IN A SUBSTANTIALLY PARALLEL ADDRESS WITH REGARD TO THE FOUNDATION (2) OF THE WORK (1). A COMPLETE SIDE WALL OF THE WORK (1) CAN BE POINTED IN AN INDIVIDUAL OPERATION WITHOUT DEBILITATION REQUIRED OF THE EXISTING BASE. BY MUTUAL COUPLING OF A PLURALITY OF LONG SUPPORTED ELEMENTS (5), A TYPE OF LONG SURFACE FOUNDATION CAN BE CREATED THAT SUPPORTS THE WORK SAFELY (1). THE ARCHITECTURAL SUBSTANCE OF VERY OLD BUILDINGS MAY BE PRESERVED IN A NON-AGGRESSIVE WAY. ADDITIONALLY THE PROCESS CAN BE CARRIED OUT VERY QUICKLY AND RELATIVELY WITH LOW COST.

Building underpinning process

Processo para o calcamento de edificios

Method of supporting structures

A process is disclosed for underpinning buildings. At least one elongated supporting element (5) is arranged below the building (1) that needs to be underpinned in a substantially parallel direction to a foundation (2) of the building (1). A whole side wall of the building (1) may thus be underpinned in a single operation without unnecessarily weakening the existing underground. By mutually coupling a plurality of elongated supporting elements (5), a kind of large-surface foundation that securely supports the building (1) can be created. The architectonic substance of very old buildings may thus be preserved in a non-aggressive manner. In addition, the process can be carried out very quickly and at a relatively low cost.

Building underpinning process

A process is disclosed for underpinning buildings. At least one elongated supporting element (5) is arranged below the building (1) that needs to be underpinned in a substantially parallel direction to a foundation (2) of the building (1). A whole side wall of the building (1) may thus be underpinned in a single operation without unnecessarily weakening the existing underground. By mutually coupling a plurality of elongated supporting elements (5), a kind of large-surface foundation that securely supports the building (1) can be created. The architectonic substance of very old buildings may thus be preserved in a non-aggressive manner. In addition, the process can be carried out very quickly and at a relatively low cost.

PROCESS FOR UNDER CONSTRUCTION

Polyethylene compositions and films including polyethylene compositions

Polyethylene compositions are disclosed that may have a density of 0.910 g/cm3 to 0.924 g/cm3 and a melt index (I2) of 0.1 g/10 minutes to 0.5 g/10 minutes and include a first polyethylene fraction area in the temperature range from 45°C to 80°C of an elution profile via improved comonomer composition distribution (iCCD) analysis method; a second polyethylene fraction area in the temperature range from 80°C to 95°C of the elution profile, and a third polyethylene fraction area in the temperature range from 95°C to 110°C of the elution profile. The second polyethylene fraction area may include at least 5% of the total area of the elution profile. The third polyethylene fraction area may include at least 25% of the total area of the elution profile. A ratio of the first polyethylene fraction area to the second polyethylene fraction area may be from 6 to 15.

Plastomer toughened/stiffened polyolefin multilayer films and laminates comprising same

The present disclosure provides for a multilayer film having a sealant layer and a first layer, where the first layer is formed from a first polyolefin composition, and a laminate that includes the multilayer film. The first polyolefin composition of the first layer consists essentially of a high density polyethylene (HDPE) resin and a propylene-ethylene copolymer thermoplastic elastomer (TPE). In addition to the first layer of the first polyolefin composition and the sealant layer, the laminate also includes a substrate film and an adhesive layer comprising polyurethane in adhering contact with the substrate film and the first layer, where when the adhesive layer is formed from a solvent-free adhesive the adhesive layer has an elastic modulus of greater than 25 MPa, and when the adhesive layer is formed from a solvent-based adhesive the adhesive layer has an elastic modulus of greater than 0.30 MPa, the elastic modulus being measured for the polyurethane in accordance with ASTM D412.

Spout pouch and method of making same

The present disclosure includes a process for making a package having a spout. The process includes heating a sealing area of a spout to a temperature at or above a melting point of the spout material; heating two multilayer structures around a portion of their peripheries to adhere the peripheries of sealant layers and form a partially sealed package having an opening; inserting the heated spout into the opening; and pressing opposing surfaces of the two multilayer structures around the spout to close the opening around the spout. Each multilayer structure includes a multilayer film having the sealant layer having at least 40% by weight of an ethylene-based polymer having a melting point below 112C; an external layer including an ethylene-based polymer; and at least one intermediate layer disposed between the sealant layer and the external layer having a melting point at least 15C higher than the sealant layer.

Multilayer films for use in flexible packaging materials

A multilayer film includes a first film including at least a first layer and a second layer, and a second film extrusion coated onto the first layer of the first film. The multilayer film is free of adhesives. The first layer of the first film includes a first high density polyethylene (HDPE) having a density of from 0.935 to 0.965 g/cc and a melt index I2 of 0.3 to 2.0 and the second layer of the first film includes a polyolefin plastomer having a density of from 0.885 to 0.910 g/cc. The second film includes a second high density polyethylene (HDPE) having a density of from 0.945 to 0.965 g/cc and a melt index I?2#191 of 4.0 to 20.0. The second film has a gloss of from 65% to 95% at 60 according to ASTM D2457.

Thermoformable multilayer films and methods of producing the same

Embodiments of multilayer films are disclosed comprising a first layer comprising polyethylene, a second layer comprising a first medium density polyethylene; a barrier layer; a third layer comprising a second medium density polyethylene; and a fourth layer comprising polyethylene. The second layer may be positioned between the first layer and the barrier layer. The barrier layer may be positioned between the second layer and the third layer.

Multilayer films comprising polyethylene and barrier layers and methods of producing the same

Embodiments of multilayer films are disclosed comprising a first layer comprising polyethylene, a second layer comprising a first medium density polyethylene; a barrier layer; a third layer comprising a second medium density polyethylene; and a fourth layer comprising polyethylene. The second layer may be positioned between the first layer and the barrier layer. The barrier layer may be positioned between the second layer and the third layer.

Thermoformable multilayer films and methods of producing the same

Embodiments of multilayer films are disclosed comprising a first layer comprising polyethylene, a second layer comprising a first medium density polyethylene; a barrier layer; a third layer comprising a second medium density polyethylene; and a fourth layer comprising polyethylene. The second layer may be positioned between the first layer and the barrier layer. The barrier layer may be positioned between the second layer and the third layer.

Plastomer toughened/stiffened polyolefin multilayer films and laminates comprising same

The present disclosure provides for a multilayer film having a sealant layer and a first layer, where the first layer is formed from a first polyolefin composition, and a laminate that includes the multilayer film. The first polyolefin composition of the first layer consists essentially of a high density polyethylene (HDPE) resin and a propylene-ethylene copolymer thermoplastic elastomer (TPE). In addition to the first layer of the first polyolefin composition and the sealant layer, the laminate also includes a substrate film and an adhesive layer comprising polyurethane in adhering contact with the substrate film and the first layer, where when the adhesive layer is formed from a solvent-free adhesive the adhesive layer has an elastic modulus of greater than 25 MPa, and when the adhesive layer is formed from a solvent- based adhesive the adhesive layer has an elastic modulus of greater than 0.30 MPa, the elastic modulus being measured for the polyurethane in accordance with ASTM D412.

Multilayer films for use in flexible packaging materials

Artificial turf grass with natural appearance

Disclosed herein is a turf filament comprising from 50 to 99.5 weight percent of a base polymer selected from polyolefins, polyamides, polyesters and combinations thereof, from 0.1 to 20 weight percent of polymer particles having a core and a shell structure where the core comprises a first polymeric material having a first refractive index and the shell comprises a second polymeric material having a second refractive index that is different from the first refractive index, from 0.5 to 30 weight percent of a compatibilizer and from 0 to 10 weight percent of a colorant based on total weight of the filaments. Also disclosed is a synthetic turf comprising such filaments. These filaments provide a turf with a natural appearance.

Process for the accelerated solidification of hydraulic cement mixture

The solidification of hydraulic cement mixtures can be accelerated by addition of crystalline zeolites. Preferably, there are employed zeolites of Types A, X, and P.

Process for increasing the bleaching efficiency of an inorganic persalt or of hydrogen peroxide

A process for increasing the bleaching efficiency of an inorganic persalt or hydrogen peroxide by adding to said persalt or H₂O₂ an activating agent. The activating agent is an acetylated gluconic acid derivative, such as N-methyl pentaacetyl gluconamide, N-methyl-N-acetyl pentaacetyl gluconamide, N-methyl-N-acetyl pentaacetyl gluconamide or tetraacetyl gluconolactone. The invention also relates to the acetylated gluconic acid derivatives themselves.

Bladder

The invention relates to a bladder for an inflatable ball including structure for receiving an electronic device therein. The structure facilitates at least one of cushioning, positioning, locating, and supporting the electronic device. The structure cushions reaction forces arising from a foot strike to the bladder and/or provides a restoring force to the electronic device subsequent to a foot strike to maintain the device in its predetermined position.

Bladder

The invention relates to a bladder for an inflatable ball including structure for receiving an electronic device therein. The structure facilitates at least one of cushioning, positioning, locating, and supporting the electronic device. The structure cushions reaction forces arising from a foot strike to the bladder and/or provides a restoring force to the electronic device subsequent to a foot strike to maintain the device in its predetermined position.

Production of metal-organic frameworks

An apparatus for producing metal organic frameworks, comprising: a tubular flow reactor (105; 205; 305; 405) comprising a tubular body (406) into which, in use, precursor compounds which form the metal organic framework are fed and flow, said tubular body (406) including at least one annular loop. (Figure 1)

Apparatus for measuring impedance of body tissue

An apparatus for measuring the impedance of body tissue has a signal source connected to the tissue to be measured which supplies an electrical signal to the tissue, a unit for acquiring an impedance signal from the body tissue dependent on the electrical signal, and an evaluation stage for the impedance signal. The evaluation stage filters out low frequency signal components corresponding to the conductance of the tissue, and has a signal output to which the signal components which were filtered out are supplied.

Method for nucleic acid amplification and detection using adhered probes

Nucleic acids can be amplified and detected using an element which has a sealable support on which is disposed a nucleic acid reagent composition. The composition is a mixture of a nucleic acid reagent composed of polymeric particles to which an oligonucleotide is covalently attached. The particles are prepared from a first polymer having a glass transition temperature of at least about 70° C. and have an average diameter of from about 0.1 to about 3 micrometers. The reagent is adhered to the support using a water insoluble adhesive comprising a second polymer which has a glass transition temperature which is at least about 30° C. less than the glass transition temperature of the first polymer. The adhesive is present in the composition at from about 1 to about 20 dry weight percent. The method provides high sensitivity and low background in the assay of nucleic acids, preferably using polymerase chain reaction.

High throughput screen for biologically active polypeptides

Methods for screening libraries of polypeptides for biologically activity on cells. For example, polypeptides can be synthesized and encapsulated along with their coding sequences in microcapsules of an emulsion. Emulsion microcapsules can then be fused with microcapsules comprising test cells and biological activity on the cells is assessed to identify biologically active polypeptides and nucleic acid molecules encoding the same.

Polypeptide variants

The present invention relates to polypeptide variants and methods for obtaining variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.

Cleaning compositions comprising dispersin variants

The present invention relates to specific cleaning compositions comprising novel dispersin variants having improved properties relative to the parent dispersin. Such properties may include one or more of the following; wash performance, stability e.g. detergent and/or storage stability. The cleaning compositions described herein are suitable for use in cleaning processes and include detergent compositions, such as laundry compositions and dish wash compositions, including hand wash and automatic dish wash compositions.

Stabilized cellulase variants

Disclosed is variants of a cellulase having improved stability in the presence of a protease, and the use of such variants in laundry.

Stabilized cellulase variants

Disclosed are variants of a cellulase having improved stability in the presence of a protease, and the use of such variants in laundry.

Stabilized glycoside hydrolase variants

Disclosed are variants of a glycoside hydrolase having improved stability, e.g., in the presence of a protease, and the use of such variants in detergent applications, such as laundry or dish wash.

INJECTOR OF A MIXTURE OF AIR AND FUEL FOR A TURBOMACHINE COMBUSTION CHAMBER

Injecteur (12’) d’un mélange d’air et de carburant pour une chambre de combustion (10) d’une turbomachine, en particulier d’aéronef, comportant un corps (14) comprenant ou définissant au moins un circuit de carburant (16) et au moins un circuit d’air (18), l’injecteur comportant en outre une coupole (20’) située à une extrémité dudit corps et configurée pour délimiter une chambre (22) de prémélange de l’air et du carburant sortant desdits circuits, la coupole comportant une ouverture (24’) de projection d’un cône air-carburant, caractérisé en ce que cette ouverture a un bord périphérique (26’) présentant des encoches (30’). Figure pour l’abrégé : Figure 3 Injector (12 ') of an air and fuel mixture for a combustion chamber (10) of a turbomachine, in particular of an aircraft, comprising a body (14) comprising or defining at least one fuel circuit ( 16) and at least one air circuit (18), the injector further comprising a dome (20 ') located at one end of said body and configured to delimit a chamber (22) for premixing the air and the fuel leaving said circuits, the dome comprising an opening (24 ') for projecting an air-fuel cone, characterized in that this opening has a peripheral edge (26') having notches (30 '). Figure for the abstract: Figure 3

Process for increasing the bleaching efficiency of an inorganic persalt

Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses

The present invention is directed to compound of the formula I: wherein R 1 , R 2 , R 3 , R 4 , R 5 , X, Y, and  are as defined herein. These compounds are useful for inhibiting the activity of a metalloproteinase by contacting the metalloproteinase with an effective amount of the inventive compounds.

Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use

The present invention is directed to compound of the formula I: wherein R 1 , R 2 , R 3 , R 4 , R 5 , X, Y, and are as defined herein. These compounds are useful for inhibiting the activity of a metalloproteinase by contacting the metalloproteinase with an effective amount of the inventive compounds.

Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use

The present invention is directed to compound of the formula I:wherein R1, R2, R3, R4, R 5, X, Y, andare as defined herein.These compounds are useful for inhibiting the activity of a metalloproteinase by contacting the metalloproteinase with an effective amount of the inventive compounds.

Stabilized cellulase variants

Disclosed is variants of a cellulase having improved stability in the presence of a protease, and the use of such variants in laundry.

Polypeptide variants

The present invention relates to polypeptide variants and methods for obtaining variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.

Inductive coupled RFID transponder

The transponder has a transmission- and reception coil (SP) in cooperation with a laser-activated ferrite compound (LAFC) for guiding magnetic flux, where the coil and the ferrite compound form an integrated component. The compound is formed from composite material made of plastic i.e. liquid crystal polymer, and ferrite powder, where the plastic is laser-structurable. The coil is formed by a conductor path (LB) pre-contoured and metallized by a laser machining process in or on a surface of the compound. Electronic components of an operating electronic circuit are attached to the compound. An independent claim is also included for a method for manufacturing an inductive coupled radio frequency identification (RFID) transponder.

System and method for supplying power to electrically operated loads, and motor vehicle

A system (2) for supplying power to electrically operated loads (9, 9a, 9b, 11, 11a, 24, 25) for a motor vehicle comprises a first on-board electrical system (3), which comprises a rechargeable first energy storage means (8), and a second on-board electrical system (4). The system (2) comprises a first DC voltage converter (5) and a second controllable DC voltage converter (6), said DC voltage converters being connected between the first on-board electrical system (3) and the second on-board electrical system (4) and it being possible to activate said DC voltage converters in order to route electrical power at least from the second on-board electrical system (4) to the first on-board electrical system (3). The system (2) comprises a control device (7, 13) which is coupled to the second DC voltage converter (6) and is designed in order to selectively activate the second DC voltage converter (6) for the purpose of charging the first energy storage means (8), depending on the state of charge of the first energy storage means (8).

Multiple bi-specific binding domain constructs with different epitope binding to treat cancer

Groups of bi-specific binding domain constructs (BS-BDC) to treat cancer are described. Each BS-BDC in a group targets a cancer antigen epitope and an immune cell activating epitope that is different from the cancer antigen epitope and immune cell activating epitope targeted by another BS-BDC in the group. The different cancer antigen epitopes can be on the same cancer antigen.

Chelating platform for delivery of radionuclides

Siderocalin-metal chelator combinations that bind metallic radioisotopes used in nuclear medicine with high affinity are described. The high affinity siderocalin-metal chelator combinations include a number of chelator backbone arrangements with functional groups that coordinate with metals. The siderocalin-metal chelator combinations can be used to deliver radionuclides for imaging and therapeutic purposes.

Phase module for a power converter

Die Erfindung betrifft ein Phasenmodul (1) für einen Stromrichter (2) aufweisend mindestens ein Schaltelement (10) und einen Kühlkörper (13). Zur Verbesserung der Kühleigenschaft eines Phasenmoduls (1) wird vorgeschlagen, dass das Schaltelement (10) mit dem Kühlkörper (13) verbunden ist, wobei die Verbindung zwischen Schaltelement (10) und Kühlkörper (13) eine nichtlösbare Verbindung ist. Die Erfindung betrifft weiter einen Stromrichter (2) mit mindestens einem solchen Phasenmodul (1) sowie ein Verfahren zur Herstellung eines derartigen Phasenmoduls (1), wobei zur Herstellung einer Verbindung zwischen dem Schaltelement (10) und dem Kühlkörper (13) das Schaltelement (10) auf den Kühlkörper (13) gelötet, gesintert oder geklebt wird. The invention relates to a phase module (1) for a power converter (2) comprising at least one switching element (10) and a heat sink (13). To improve the cooling property of a phase module (1), it is proposed that the switching element (10) is connected to the heat sink (13), wherein the connection between the switching element (10) and heat sink (13) is a non-detachable connection. The invention further relates to a power converter (2) having at least one such phase module (1) and to a method for producing such a phase module (1), wherein the switching element (10) is used to establish a connection between the switching element (10) and the heat sink (13) ) is soldered, sintered or glued to the heat sink (13).

Combination of epigenetic factors and bispecific compounds targeting cd33 and cd3 in the treatment of myeloid leukemia

The present invention provides a combination epigenetic factors and bispecific compounds targeting CD33 and CD3 in the treatment of myeloid leukemia, wherein the epigenetic factor is selected from the group consisting of histone deacetylase (HDAC) inhibitors, DNA methyltransferase (DNMT) I inhibitors,hydroxyurea, Granulocyte-Colony Stimulating Factor (G-CSF), histone demethylase inhibitors and ATRA (All Trans-retinoic acid). Accordingly, the invention provides a pharmaceutical composition comprising a CD33 targeting compound and at least one epigenetic factor and an epigenetic factor for use in the amelioration and/or treatment of a myeloid leukemia, wherein the epigenetic factor increases the responsiveness of a patient to a CD33 targeting compound. Moreover, the invention provides the use of at least one an epigenetic factor for increasing the responsiveness of a myeloid leukemia patient to a treatment with a CD33 targeting compound, a method for the treatment of a myeloid leukemia, the method comprising the administration of at least one epigenetic factor and a CD33 targeting compound to a patient in the need thereof and a kit comprising a pharmaceutical composition of the invention or an epigenetic factor of the invention and a bispecific CD33 targeting compound.

Combination of epigenetic factors and bispecific compounds targeting CD33 and CD3 in the treatment of myeloid leukemia

The present invention provides a combination epigenetic factors and bispecific compounds targeting CD33 and CD3 in the treatment of myeloid leukemia, wherein the epigenetic factor is selected from the group consisting of histone deacetylase (HDAC) inhibitors, DNA methyltransferase (DNMT) I inhibitors, hydroxyurea, Granulocyte-Colony Stimulating Factor (G-CSF), histone demethylase inhibitors and ATRA (All Trans-retinoic acid). Accordingly, the invention provides a pharmaceutical composition comprising a CD33 targeting compound and at least one epigenetic factor and an epigenetic factor for use in the amelioration and/or treatment of a myeloid leukemia, wherein the epigenetic factor increases the responsiveness of a patient to a CD33 targeting compound. Moreover, the invention provides the use of at least one an epigenetic factor for increasing the responsiveness of a myeloid leukemia patient to a treatment with a CD33 targeting compound, a method for the treatment of a myeloid leukemia, the method comprising the administration of at least one epigenetic factor and a CD33 targeting compound to a patient in the need thereof and a kit comprising a pharmaceutical composition of the invention or an epigenetic factor of the invention and a bispecific CD33 targeting compound.

Xylanase variants and polynucleotides encoding same

The present invention relates to xylanase variants, polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; compositions comprising the xylanase variants and methods of using the variants.

Xylanase variants and polynucleotides encoding same

The present invention relates to xylanase variants, polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; compositions comprising the xylanase variants and methods of using the variants.

Bandage

The invention relates to the bandage whose length exceeds its width and which comprises a central part (1a) and a respective bandage-securing end part (1b, 1c) located at each end of the central part. One surface of each securing end part is coated with an adhesive layer. The bandage, or tape, is intended for therapeutic remedial purposes with patients suffering from neck and spinal disorders. When in use, one end (1c) of the bandage or tape is affixed to a section of the skin (2) located in the vicinity of the sacrum, and the other end (1d) is affixed to a section of the skin (3) in the vicinity of the lower or intermediate thoracic vertebrae. The length of the tape or bandage measured between the points of attachment when the spine is fully erect and therewith in a correct position is shorter than the distance measured between the skin sections when the spine is forwardly arched (4).

Shut-off valve has spindle which can be moved axially using lockable hand wheel, limiter which limits amount by which spindle can rise and protective cap screwed on to this

The shut-off valve has a spindle (3) which can be moved axially using a lockable hand wheel (5) and a limiter (6) which limits the amount by which the spindle can rise. A protective cap (7) with an internal thread is screwed on to this. The limiter can be locked against axial movement using the limiter.

Electronic smoking device and cartridge

A capsule (6) contains a liquid (28) to be supplied to an atomizer (20) and is mounted on or in an electronic smoking device (1). The capsule (6) has a controller (40) including a memory, which receives data from and transmits data to control electronics (14) of the electronic smoking device (1). A capacitor in the capsule (6) is charged by the electronic smoking device (1) and powers the controller (40) during intermediate intervals. Electrical contacts (26, 48) of the capsule are connected to electrical contacts (24, 46) of the electronic smoking device (1) to charge the capacitor and exchange data.

METHOD AND DEVICE FOR CONTROLLING THE INSTALLATION OF BRAKES OF A VEHICLE