Agent for temporarily reshaping keratin-containing fibers comprising preservative I

La présente invention concerne un agent cosmétique stable à la conservation et destiné à la mise en forme temporaire des fibres kératiniques et, en particulier, des cheveux humains qui offre une protection améliorée contre la séparation de phase et une stabilité microbiologique accrue.

Gel-like hair-setting agent

La présente invention concerne une composition cosmétique, contenant de la dioxyde de silicium, destinée à fixer les cheveux et à mettre en forme temporairement des fibres de kératine, en particulier des cheveux humains, laquelle composition permet de conférer, en fonction de l'application, un aspect aussi bien mat que brillant, permet d'effectuer une mise en forme et une remise en forme de la coiffure sur une longue période après application sur les cheveux et ne forme pas de résidus visibles.

DISPLAY DEVICE

Agent for temporarily reshaping keratin-containing fibres comprising presevative IV

La présente invention concerne un agent cosmétique stable à la conservation et destiné à la mise en forme temporaire des fibres kératiniques et, en particulier, des cheveux humains qui offre une protection améliorée contre la décoloration des fibres kératiniques.

DEVICE FOR RECORDING A FREQUENCY AND METHOD FOR RECORDING AND REPRODUCING A FREQUENCY

DISPLAY DEVICE, IN PARTICULAR FOR A MOTOR VEHICLE

Mixture of substances for styling agent

Agent cosmétique pour la mise en forme temporaire de fibres kératiniques, notamment de cheveux humains, contenant dans un support cosmétique et rapporté à son poids total, a) 0,05 à 5,0 % en poids d'au moins un homo- ou copolymère de sel de (méth)acrylamidopropyltriméthylammonium ; b) 0,5 à 10 % en poids de polyimide, utilisation de cet agent et procédé recourant à cet agent.

Exhaust system`s part suspending device for motor vehicle, has mounting part fastened at flange and detachable from flange in mounting end position such that attachment part is attachable in bearing and/or detachable from bearing

Dans un dispositif pour accrocher au moins une partie d'une installation de gaz d'échappement d'un véhicule automobile, comprenant une structure susceptible d'être fixée sur une partie de la carrosserie du véhicule automobile, et présentant un palier, notamment un support de pivotement sur lequel est logée une pièce d'accrochage élastique, notamment de façon pivotante, sur laquelle pièce d'accrochage on peut accrocher au moins la partie de l'installation de gaz d'échappement, on a prévu que la structure comprenne un flasque (3) à fixer sur la partie de carrosserie et une pièce de montage (5) séparée du flasque, la pièce d'accrochage pouvant être fixée et/ou retirée dans sa position séparée sur le support et la pièce de montage pouvant être fixée sur le flasque dans une position finale de montage.

SEMICONDUCTOR DEVICE AND METHOD FOR DETERMINING THE CONDITION OF THE SEMICONDUCTOR MATERIAL OF THIS COMPONENT

Composant semi-conducteur (108) sensible à au moins un composant de fluide. Le composant semi-conducteur (108) comprend, un substrat (110) semi-conducteur, et ayant sur un côté un contact (112), une électrode (114) sur le second côté (110) et isolé de la matière semiconductrice (110) par une couche isolante chimio-sensible (118), un branchement (116) pour mesurer la tension entre ce branchement (116) et le contact de substrat (112). Le branchement (116) est décalé latéralement par rapport à l'électrode (114) sur le second côté du substrat (110) et la matière semi-conductrice est dopée de façon conductrice dans la région du branchement (116).

CHRONOMETER AND METHOD OF DETERMINING A DURATION

Chronomètre (8) comportant un dispositif (1) dont l'état varie dans le temps et une unité d'exploitation (2) dans laquelle est enregistré un état de référence (3). Le dispositif (1) a une structure dont la résistance électrique varie dans le temps et, l'unité d'exploitation (2) détermine la durée (t) par comparaison à une valeur représentant la résistance électrique de la structure (4) à l'état de référence (3).

Agent for temporarily reshaping keratin-containing fibres comprising presevative III

La présente invention concerne un agent cosmétique pour la mise en forme temporaire des fibres kératiniques et en particulier des cheveux humains qui est stable à la conservation.

PROCESS AND DEVICE OF DETECTION OF the PRESENCE Of an OBSTACLE Near UNOBJET, IN PARTICULAR Of a VEHICLE

Agent for temporarily reshaping keratin-containing fibers comprising preserative II

La présente invention concerne un agent cosmétique stable à la conservation et destiné à la mise en forme temporaire des fibres kératiniques et, en particulier, des cheveux humains qui offre une protection améliorée contre la séparation de phase et une stabilité microbiologique accrue.

DEVICE FOR the FIXING Of AT LEAST PART Of an INSTALLATION OF FUMES EXHAUST Of a MOTOR VEHICLE.

DEVICE TO RECORD a FREQUENCY AND PROCESS Of RECORDING AND READING Of a FREQUENCY

Dispositif (100) pour enregistrer une fréquence comprenant : - un comparateur (102) avec une entrée et une sortie ainsi qu'une entrée de tension d'alimentation et une sortie de tension d'alimentation, et - une memristance (104) branchée entre l'entrée et la sortie du comparateur (102).

CONTROL METHOD AND APPARATUS FOR MEASURING A PARAMETER OF GAS WITH A SENSITIVE FIELD EFFECT TRANSISTOR GAS

Procédé de mesure d'un paramètre de gaz (175) à l'aide d'un transistor à effet de champ sensible aux gaz (100), consistant à appliquer une tension de préparation pendant une durée préparatoire à l'électrode de porte (115) du transistor (100), saisir une grandeur de mesure (165) entre le branchement de source (140) et le branchement de drain (145) du transistor (100) pendant une durée de saisie directement après la durée préparatoire. Pendant la saisie (520) de la grandeur de mesure (165), on applique une tension de saisie à l'électrode de porte (115). On détermine le paramètre de gaz (175) en utilisant la grandeur de mesure saisie (165).

METHOD AND APPARATUS FOR DETERMINING THE CONDITION OF A SEMICONDUCTOR MATERIAL OF A FIELD EFFECT TRANSISTOR

Procédé appliqué à un transistor à effet de champ chimiosensible (110) ayant des contacts de source (112), de drain (114), de porte (116) d'une électrode de porte (126) chimio-sensible ainsi qu'un contact de substrat (118). On applique une tension entre le contact de porte (116) et un potentiel de référence (122) au transistor à effet de champ, puis on saisit (204) l'intensité du courant entre le contact de source (112) et le contact de substrat (118) et ou détermine l'état en utilisant la tension et l'intensité.

CONTROL METHOD AND APPARATUS FOR MEASURING A PARAMETER OF GAS WITH A FIELD EFFECT TRANSISTOR GAS SENSITIVE

Verfahren zur Herstellung metallhaltiger Azofarbstoffe

VERFAHREN ZUR HERSTELLUNG VON NEUEN CARBONSAEUREAMIDEN

METHOD FOR OBTAINING OF 4- ACYLAMINO- PHENYL- ETHANOLAMINES

METHOD OF PREPARING BENZYLAMINES

METHOD FOR OBTAINING OF 4- ACYLAMINO- PHENYL- ETHANOLAMINES

METHOD OF OBTAINING 4-AMINO-3,5-DIHALOGENPHENYL-ETHANOLAMINES

METHOD FOR THE PREPARATION OF CARBOHYDRATE CLEAVAGE PRODUCTS FROM A LIGNOCELLULOSIC MATERIAL

A method for the preparation of carbohydrate cleavage products, characterized by the combination of the measures that the lignocellulosic material is treated with an aqueous solution containing hydrogen peroxide, an alcohol, in particular a Calcohol or a phenol, and a base in order to oxidatively break down lignocellulose and to separate cleavage products from the material, and that the obtained material enriched with cellulose and hemicelluloses is treated with a carbohydrate-cleavage enzyme in order to prepare the carbohydrate cleavage products. 1. A method for the production of carbohydrate cleavage products , comprising a combination of measures thatlignocellulosic material is treated with an aqueous solution containing hydrogen peroxide, an alcohol or a phenol, and a base in order to oxidatively break down lignocellulose and to separate cleavage products from the material, wherein there is obtained a material enriched with cellulose and hemicellulose, andthe obtained material enriched with cellulose and hemicellulose is treated with a carbohydrate-cleaving enzyme in order to prepare carbohydrate cleavage products.2. A method according to claim 1 , wherein the cleavage is carried out at a temperature below 100° C.3. A method according to claim 1 , wherein the aqueous solution has a pH before the treatment of the lignocellulosic material that is larger than 10.0 and less than 12.0 claim 1 , in particular less than 11.0.4. A method according to wherein there is not added any base during the treatment.5. A method according to claim 1 , wherein there is used as lignocellulosic material straw claim 1 , energy crops and/or bran.6. A method according to claim 1 , wherein the lignocellulosic material is present in the aqueous solution in a material density of 5-40% by weight.7. A method according to claim 1 , wherein the material enriched with cellulose and hemicellulose is treated with a xylanase and/or cellulose in order to prepare the sugars.8. A method according to ...

ARRANGEMENT AND METHOD FOR DAMPING OF A PISTON MOVEMENT

Arrangement for damping of a piston movement in a compressed air cylinder (), which arrangement includes a compressed air cylinder (), a valve device, a compressed air device, and a control unit. The control unit controls valve devices such that the movement of the piston is damped before the piston reaches the casing of the compressed air cylinder. A method for control of the arrangement is disclosed. 1. An arrangement for damping of a piston movement in a compressed air cylinder wherein the arrangement comprises:a compressed air cylinder, with at least one longitudinal spindle for transmission of force from the compressed air cylinder, the compressed air cylinder comprises a casing;a piston movable longitudinally in the cylinder and joined to the longitudinal spindle for moving the piston longitudinally in the cylinder, the piston is shaped and placed in the cylinder such that a respective space is formed in the cylinder on each side of the piston, a compressed air hose or pipe connected to each space;a valve device arranged along each compressed air hose or pipe;a compressed air device for supplying compressed air to each space via respective ones of the compressed air hoses or pipes, anda control unit connected to each valve device, the control unit is configured and operable to control each valve device when compressed air is supplied to or allowed to leave each space in the compressed air cylinder via the compressed air hoses or pipes, the control unit is configured and operable for controlling the valve devices to control the supply of compressed air to the respective spaces in the compressed air cylinder to supply compressed air to a first one of the spaces to generate a movement of the piston and the spindle thereto connected, and the valve devices are controlled so that compressed air is supplied to the second one of the spaces before movement of the piston has begun, in order thereby to damp the movement of the piston caused by the air supplied to the ...

PROCESS FOR THE PRODUCTION OF CARBOHYDRATE CLEAVAGE PRODUCTS FROM A LIGNOCELLULOSIC MATERIAL

A process for the production of carbohydrate cleavage products, characterized by a combination of the measures that a lignocellulosic material is treated with an aqueous solution containing an alcohol, in particular a C-alcohol or a phenol, and having a pH-value of between 11.0 and 14.0 in order to cleave lignocellulose and separate cleavage products from the material, whereby a material enriched with cellulose and hemicellulose is obtained, and the obtained material enriched with cellulose and hemicellulose is treated with at least one carbohydrate-cleaving enzyme in order to obtain the carbohydrate cleavage products. 1. A process for the production of carbohydrate cleavage products , the process comprising:treating a lignocellulosic material with an aqueous solution containing an alcohol and having a pH-value of between 11.0 and 14.0 in order to cleave lignocellulose and separate cleavage products from the material, whereby a material enriched with cellulose and hemicellulose is obtained, andtreating the obtained material enriched with cellulose and hemicellulose with at least one carbohydrate-cleaving enzyme in order to obtain the carbohydrate cleavage products.2. A process according to claim 1 , wherein the aqueous solution has a pH-value of between 11.0 and 13.0.3. A process according to claim 1 , wherein the cleavage occurs at a temperature of below 100° C.4. A process according to claim 3 , wherein the cleavage occurs at a temperature of below 40° C.5. A process according to claim 1 , wherein straw claim 1 , bagasse claim 1 , energy grasses and/or spelts are used as a lignocellulosic material.6. A process according to claim 1 , wherein the lignocellulosic material is present in the aqueous solution in a stock density of 5-40% by weight.7. A process according to claim 1 , wherein the material enriched with cellulose and hemicellulose is treated with a xylanase and/or a cellulase in order to extract the sugars.8. A process according to claim 1 , wherein the ...

PREPARATION OF LIGNIN

A method for the preparation of lignin from lignocellulosic material by pulping with alcohol, in particular with a Calcohol, water and a base, in particular NaOH, at a temperature below 100° C., in particular from 40° C. to 90° C., in particular from 50° C. to 70° C., characterized in that 3 to 12 parts of base, in particular 4 to 10 parts of base, in particular preferable 5 to 8 parts of base, are used per 100 parts of the dry lignocellulosic material to be pulped. 1. A method for the preparation of lignin from lignocellulosic material by pulping with alcohol , water and a base , at a temperature below 100° C. , characterized in that 3 to 12 parts of base , are used per 100 parts of the dry lignocellulosic material to be pulped.2. The method according to claim 1 , characterized in that the ratio of water to alcohol is in a range from 10:90 to 90:10.3. The method according to claim 1 , characterized in that there is used a pulping period of 2 hours to 36 hours.4. The method according to claim 1 , characterized in that there is used as lignocellulosic material straw claim 1 , energy crops claim 1 , and/or glumes.5. The method according to claim 18 , characterized in that isopropanol is used as Calcohol.6. The method according to claim 18 , characterized in that ethanol is used as Calcohol.7. The method of claim 1 , wherein the temperature is between 40° C. to 90° C.8. The method of claim 1 , wherein the temperature is between 50° C. to 70° C.9. The method of claim 1 , wherein 4 to 10 parts of base are used per 100 parts of the dry lignocellulosic material to be pulped.10. The method of claim 1 , wherein 5 to 8 parts of base are used per 100 parts of the dry lignocellulosic material to be pulped.11. The method according to claim 1 , wherein the ratio of water to alcohol is in a range from 20:80 to 40:60.12. The method according to claim 1 , wherein the ratio of water to alcohol is in a range from 60:40 to 90:10.13. The method according to claim 1 , wherein there is ...

METHOD FOR PRODUCING LIGNIN DERIVATIVES

A method for producing lignin derivatives from technical lignins by treatment with proteolytic enzymes (proteases), characterized in that the proteolytic treatment of the technical lignins significantly reduces the molar mass thereof. 1. A method for the preparation of lignin derivatives from technical lignin or from a fraction obtained from technical lignin with a protease enzyme or with a mixture of different protease enzymes , characterized in that the molar mass of the technical lignin or of the fractions obtained from technical lignin is significantly reduced by treatment with the protease enzyme or the mixture of the different protease enzymes , respectively.2. The method according to claim 1 , characterized in that the technical lignin is obtained from lignocellulosic material claim 1 , in particular straw claim 1 , bagasse claim 1 , energy crops claim 1 , in particular elephant grass claim 1 , switch grass and/or glumes claim 1 , in particular lemmas.3. The method according to claim 1 , characterized in that the technical lignin is lignin obtained by way of pulping lignocellulose.4. The method according to claim 1 , characterized in that the technical lignin is obtained from lignocellulosic material claim 1 , in particular wood claim 1 , wood fibres claim 1 , wood shavings and/or wood chips.54. The method according to any of - claims 1 , characterized in that the technical lignin obtained from lignocellulosic material is a lignosulfonate claims 1 , kraft lignin claims 1 , alkaline lignin and/or organosolv lignin.64. The method according to any of - claims 1 , characterized in that higher-molecular lignin fractions are used claims 1 , which have a protein percentage that is above average.7. The method according to any of to claims 1 , characterized in that the peptides and/or amino acids developing upon the treatment with protease enzymes are separated from the lignin claims 1 , in particular by means of membrane filtration and/or precipitation and/or ...

Operating Method for a Motor Vehicle Diesel Engine Having an Exhaust Emission Control System

An operating method is provided for a motor vehicle diesel engine having an exhaust emission control system that includes a three-way catalytic converter and an SCR catalytic converter situated one behind the other in the flow direction of the exhaust gas. The diesel engine is operated, at least intermittently, with an air-fuel ratio of approximately λ=1.0 in a first operating range in which the SCR catalytic converter falls below a predefinable minimum temperature and with excess air that is typical for normal diesel engine operation in a second operating range in which the SCR catalytic converter exceeds the predefinable minimum temperature. An output signal of an exhaust gas sensor situated downstream from the three-way catalytic converter and which is correlated with a NOx concentration of the exhaust gas is used to set the air-fuel ratio in the first operating range.

PROCESS FOR THE PRODUCTION OF FURAN DERIVATIVES FROM GLUCOSE

A process for the production of furan derivatives from D-glucose, wherein 1. A process for the production of furan derivatives from D-glucose , characterized in thatA) D-glucose is converted into D-fructose in an enzymatic process, wherein redox cofactors are used and regenerated, whereby, as a result of at least two further enzymatically catalyzed redox reactions proceeding in the same reaction batch, one of the two redox cofactors accumulates in its reduced form and, respectively, the other one in its oxidized form, whereby D-glucose is converted into D-fructose, involving two or more oxidoreductases, andB) D-fructose is converted into furan derivatives.2. A process according to claim 1 , characterized in that NAD/NADH and/or NADP/NADPH are used as redox cofactors in Step A).4. A process according to claim 1 , characterized in that claim 1 , during the conversion of D-glucose into D-fructose claim 1 , at first an enzymatically catalyzed reduction and subsequently an enzymatically catalyzed oxidation are performed.5. A process according to claim 1 , characterized in that isomerization of D-glucose occurs via reduction to D-sorbitol claim 1 , which is oxidized into D-fructose.6. A process according to claim 1 , characterized in that Step A) is performed as a two-step redox process.7. A process according to claim 1 , characterized in that both the reduction and the oxidation reaction(s) for converting D-glucose into D-fructose occur in the same reaction batch claim 1 , without any intermediates being isolated.8. A process according to claim 1 , characterized in that at least one dehydrogenase as well as redox cofactor(s) are used for the conversion of D-glucose into D-fructose.9. A process according to claim 8 , characterized in that NAD/NADH and/or NADP/NADPH claim 8 , either in a soluble form or immobilized onto solids claim 8 , are used as redox cofactor(s).10. A process according to claim 1 , characterized in that the redox cofactor(s) NAD/NADH and/or NADP/NADPH ...

METHOD FOR THE ISOMERISATION OF GLUCOSE

Disclosed is a method for the isomerisation of glucose by reduction to sorbitol and subsequent oxidation to fructose, in which the redox cofactors NAD/NADH and NADP/NADPH are regenerated in a one-pot-reaction, wherein one of the two redox cofactors is obtained in the reduced form thereof and the other redox cofactor in the oxidised form thereof as a result of at least two additional enzymatically catalysed redox reactions (product forming reactions) taking place in the same reaction batch, wherein a) in the regeneration reaction, which transfers the reduced cofactor back to its originally oxidised form, oxygen or a compound of the general formula RC(O)COOH is reduced, and b) in the regeneration reaction, which transfers the oxidised cofactor back to its originally reduced form, a compound of the general formula RCH(OH)Ris oxidised, wherein R, Rand Rhave different meanings in the compounds, characterised in that a mixture of glucose and fructose is used as a starting material. Furthermore, the use of fructose thus produced in a method for producing furan derivatives is disclosed. 2. The method according to claim 1 , wherein in a) a compound of the general formula I claim 1 , wherein Ris a substituted or unsubstituted (C)alkyl group claim 1 , is reduced claim 1 , and in b) a compound of the general formula II claim 1 , wherein Rand Rare independently selected from the group consisting of H claim 1 , (C)alkyl claim 1 , wherein alkyl is straight or branched claim 1 , (C)alkenyl claim 1 , wherein alkenyl is straight or branched and optionally contains up to three double bonds claim 1 , cycloalkyl claim 1 , aryl claim 1 , (C)carboxyalkyl claim 1 , if compound I is a pyruvate claim 1 , optionally also carboxyl claim 1 , is oxidised.3. The method according to claim 1 , wherein in b) a compound of formula II claim 1 , wherein Rand Rare independently selected from the group consisting of H claim 1 , (C-C)alkyl claim 1 , wherein alkyl is straight or branched claim 1 , (C) ...

Selectable system controller for multi-processor computing systems

A system includes a computing system and a cable connector. The computing system includes a plurality of processors and an interconnect circuit configured to connect the plurality of processors to each other. The cable connector is configured to connect to the interconnect circuit and provide a channel identifier to the computing system, and the interconnect circuit is configured to set one of the plurality of processors as a system controller based on the channel identifier.

Pyridone and aza-pyridone compounds and methods of use

Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in intro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

PREPARATION OF LIGNIN

A method for the preparation of lignin from lignocellulosic material by pulping with alcohol, in particular with a Calcohol, water and a base, in particular NaOH, at a temperature below 100° C., in particular from 40° C. to 90° C., in particular from 50° C. to 70° C., characterized in that 3 to 12 parts of base, in particular 4 to 10 parts of base, in particular preferable 5 to 8 parts of base, are used per 100 parts of the dry lignocellulosic material to be pulped. 1. A method for the preparation of lignin from lignocellulosic material by pulping with alcohol , at a temperature below 100° C. , characterized in that 3 to 12 parts of base , are used per 100 parts of the dry lignocellulosic material to be pulped.2. The method according to claim 1 , characterized in that the ratio of water to alcohol is in a range from 10:90 to 90:10.3. The method according to claim 1 , characterized in that there is used a pulping period of 2 hours to 36 hours.4. The method according to claim 1 , characterized in that there is used as lignocellulosic material straw claim 1 , energy crops claim 1 , and/or glumes.5. The method according to claim 18 , characterized in that isopropanol is used as Calcohol.6. The method according to claim 18 , characterized in that ethanol is used as Calcohol.7. The method of claim 1 , wherein the temperature is between 40° C. to 90° C.8. The method of claim 1 , wherein the temperature is between 50° C. to 70° C.9. The method of claim 1 , wherein 4 to 10 parts of base are used per 100 parts of the dry lignocellulosic material to be pulped.10. The method of claim 1 , wherein 5 to 8 parts of base are used per 100 parts of the dry lignocellulosic material to be pulped.11. The method according to claim 1 , wherein the ratio of water to alcohol is in a range from 20:80 to 40:60.12. The method according to claim 1 , wherein the ratio of water to alcohol is in a range from 60:40 to 90:10.13. The method according to claim 1 , wherein there is used a pulping period ...

Substituted benzamides and methods of use thereof

The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R A , R AA , subscript n, ring A, X 2 , L, subscript m, X 1 , R 1 , R 2 , R 3 , R 4 , R 5 , and R N have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF

Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

PROCESS FOR OBTAINING LOW MOLECULAR LIGNIN (LML)

A process for obtaining resin or plastics using a lignocellulosic material by treating a lignocellulosic material with an aqueous extraction solution having a content of a C-alcohol of from 70% v/v to 95% v/v at a pH-value of from 12 to 14, whereby a first aqueous solution of low-molecular lignin (LML) is obtained, which is converted into resin or plastics; and a method of obtaining LML and a method of concentrating LML, wherein the first aqueous solution of LML is used for the treatment of additional lignocellulosic material in order to obtain aqueous solutions in which the LML is enriched compared with the first aqueous solution. 1. A process for obtaining resin or plastics using a lignocellulosic material , comprising:{'sub': '1-4', 'a) treating a lignocellulosic material with an aqueous extraction solution having a content of a C-alcohol of from 70% v/v to 95% v/v at a pH-value of from 12 to 14, whereby an aqueous solution of low-molecular lignin (LML) is obtained, and'}b) converting the low-molecular lignin obtained according to a) into resin or plastics.2. A process according to claim 1 , wherein in a) claim 1 , a first aqueous solution of a low-molecular lignin is obtained which is used to treat additional lignocellulosic material in order to enrich additional low-molecular lignin in said first solution.3. A process according to claim 1 , wherein hardwood claim 1 , softwood claim 1 , straw claim 1 , bagasse claim 1 , or annual and perennial grasses is/are used as the lignocellulosic material.4. A process according to claim 1 , wherein the low-molecular lignin obtained in a) exhibits an Mw of 2000 and less.5. A process according to claim 1 , wherein the low-molecular lignin obtained in a) exhibits an Mn of 1100 and less.6. A process according to claim 1 , wherein the low-molecular lignin obtained in a) exhibits a polydispersity of 2 and less.7. A process according to claim 1 , wherein the low-molecular lignin obtained in a) has a sugar content of 2% and less.8 ...

PROCESS FOR THE ENZYMATIC REGENERATION OF REDOX COFACTORS

A process for the enzymatic regeneration of the redox cofactors NAD/NADH and NADP/NADPH in a one-pot reaction, wherein, as a result of at least two further enzymatically catalyzed redox reactions proceeding in the same reaction batch (product-forming reactions), one of the two redox cofactors accumulates in its reduced form and, respectively, the other one in its oxidized form, characterized in that a) in the regeneration reaction which reconverts the reduced cofactor into its original oxidized form, oxygen or a compound of general formula RC(O)COOH is reduced, and b) in the regeneration reaction which reconverts the oxidized cofactor into its original reduced form, a compound of general formula RCH(OH)Ris oxidized and wherein R, Rand Rin the compounds have different meanings. 1a) in the regeneration reaction which reconverts the reduced cofactor into its original oxidized form, oxygen or a compound of general formula. A process for the enzymatic regeneration of the redox cofactors NAD/NADH and/or, in particular and, NADP/NADPH in a one-pot reaction, wherein, as a result of at least two further enzymatically catalyzed redox reactions proceeding in the same reaction batch (product-forming reactions), one of the two redox cofactors accumulates in its reduced form and, respectively, the other one in its oxidized form, characterized in that{'sub': 1', '1', '4', '1', '4, 'wherein Rrepresents a linear-chain or branched (C-C)-alkyl group or a (C-C)-carboxy alkyl group, is reduced, and'}{'sub': 4', '8, 'b) in the regeneration reaction which reconverts the oxidized cofactor into its original reduced form, a (C-C)-cycloalcanol or a compound of general formula'}{'sub': 2', '3', '1', '6', '1', '6', '6', '12', '1', '4', '3', '8, 'wherein Rand Rare independently selected from the group consisting of H, (C-C) alkyl, wherein alkyl is linear-chain or branched, (C-C) alkenyl, wherein alkenyl is linear-chain or branched and comprises one to three double bonds, aryl, C-Caryl, carboxyl, ...

PROCESS FOR ENZYMATIC PRODUCTION OF OXIDATION AND REDUCTION PRODUCTS OF MIXED SUGARS

The present invention provides a process for obtaining n+a oxidation and reduction products from a mixture of n sugars selected from the group consisting of C5 and C6 sugars, 1. A process for obtaining n+a oxidation and reduction products from a mixture of n sugars selected from the group consisting of C5 and C6 sugars ,wherein n is at least 2 and a is at least 1,wherein at least two of the sugars in the mixture are present at a non-equimolar ratio to each other,wherein, in a first stage, at least one of the sugars which are present at a non-equimolar ratio to each other is oxidized enzymatically and, at the same time, at least one of the other sugars present at a non-equimolar ratio to each other is reduced enzymatically, andwherein, in the first stage, a portion of at least one of the sugars present at a non-equimolar ratio to each other is not converted,characterized in that, in at least a second stage, at least a portion of the sugar not converted in the first stage is oxidized enzymatically by half and, respectively, is reduced enzymatically by the remaining half.2. A process according to claim 1 , characterized in that sugar acids and sugar acid lactones claim 1 , respectively claim 1 , are obtained as oxidation products claim 1 , and sugar alcohols are obtained as reduction products.3. A process according to claim 1 , characterized in that the mixture of sugars contains xylose and arabinose claim 1 , with xylose being present in excess.4. A process according to claim 3 , characterized in that arabinose is oxidized to arabonic acid or to arabonic acid lactone claim 3 , respectively claim 3 , and a portion of the xylose is reduced to xylitol in the first stage claim 3 , and claim 3 , in the second stage claim 3 , the unreacted xylose is oxidized completely or partly to xylonic acid or to xylonolactone by half and claim 3 , respectively claim 3 , the remaining half is reduced to xylitol.5. A process according to claim 3 , characterized in that arabonic acid ...

METHOD OF OBTAINING ACETATE FROM LIGNOCELLULOSE SPECIFICATION IDENTIFICATION

A method of obtaining an aqueous solution of an alkali acetate from lignocellulose, wherein lignocellulose is treated with a first aqueous extraction solution having a pH value in the range of 12 to 14 and a content of a Calcohol, in particular ethanol or isopropanol, in the range of 40% to 90%, in particular of from 75% to 85%, whereby a first aqueous solution of an alkali acetate is obtained, and wherein said first solution of an alkali acetate is used to treat additional lignocellulose in order to enrich additional acetate in said first solution. 1. A method of obtaining an aqueous solution of an alkali acetate from lignocellulose , comprising:{'sub': '1-4', 'treating lignocellulose with a first aqueous extraction solution having a pH value in the range of 12 to 14 and a content of a Calcohol in the range of 40% to 90%, whereby and obtaining a first aqueous solution of an alkali acetate is obtained, and'}treating additional lignocellulose with said first solution of an alkali acetate in order to enrich additional acetate in said first solution.2. A method according to claim 1 , wherein the Calcohol is ethanol.3. A method according to claim 1 , wherein the Calcohol is isopropanol.4. A method according to claim 1 , wherein the content of a Calcohol is in the range of 75% to 85%.5. A method according to claim 1 , characterized in that as lignocellulose hardwood claim 1 , straw claim 1 , bagasse or annual and/or perennial grasses are used.6. A method according to claim 2 , wherein the content of a Calcohol is in the range of 75% to 85%.7. A method according to claim 3 , wherein the content of a Calcohol is in the range of 75% to 85%.8. A method according to claim 2 , characterized in that as lignocellulose hardwood claim 2 , straw claim 2 , bagasse or annual and/or perennial grasses are used.9. A method according to claim 3 , characterized in that as lignocellulose hardwood claim 3 , straw claim 3 , bagasse or annual and/or perennial grasses are used.10. A method ...

PROCESS FOR THE PRODUCTION OF CARBOHYDRATE CLEAVAGE PRODUCTS FROM A LIGNOCELLULOSIC MATERIAL

A process for the production of carbohydrate cleavage products, characterized by a combination of the measures that a lignocellulosic material is treated with an aqueous solution containing an alcohol, in particular a C-alcohol or a phenol, and having a pH-value of between 11.0 and 14.0 in order to cleave lignocellulose and separate cleavage products from the material, whereby a material enriched with cellulose and hemicellulose is obtained, and the obtained material enriched with cellulose and hemicellulose is treated with at least one carbohydrate-cleaving enzyme in order to obtain the carbohydrate cleavage products. 1. A process for the production of carbohydrate cleavage products , the process comprising:treating a lignocellulosic material with an aqueous solution containing an alcohol and having a pH-value of between 11.0 and 14.0 in order to cleave lignocellulose and separate cleavage products from the material, whereby a material enriched with cellulose and hemicellulose is obtained, andtreating the obtained material enriched with cellulose and hemicellulose with at least one carbohydrate-cleaving enzyme in order to obtain the carbohydrate cleavage products.2. A process according to claim 1 , wherein the aqueous solution has a pH-value of between 11.0 and 13.0.3. A process according to claim 1 , wherein the cleavage occurs at a temperature of below 100° C.4. A process according to claim 3 , wherein the cleavage occurs at a temperature of below 40° C.5. A process according to claim 1 , wherein straw claim 1 , bagasse claim 1 , energy grasses and/or spelts are used as a lignocellulosic material.6. A process according to claim 1 , wherein the lignocellulosic material is present in the aqueous solution in a stock density of 5-40% by weight.7. A process according to claim 1 , wherein the material enriched with cellulose and hemicellulose is treated with a xylanase and/or a cellulase in order to extract the sugars.8. A process according to claim 1 , wherein the ...

PROCESS FOR ENZYMATIC PRODUCTION OF OXIDATION AND REDUCTION PRODUCTS OF MIXED SUGARS

The present invention provides a process for obtaining n+a oxidation and reduction products from a mixture of n sugars selected from the group consisting of C5 and C6 sugars, wherein n is at least 2 and a is at least 1, wherein at least two of the sugars in the mixture are present at a non-equimolar ratio to each other, wherein, in a first stage, at least one of the sugars which are present at a non-equimolar ratio to each other is oxidized enzymatically and, at the same time, at least one of the other sugars present at a non-equimolar ratio to each other is reduced enzymatically, and wherein, in the first stage, a portion of at least one of the sugars present at a non-equimolar ratio to each other is not converted, and which is characterized in that, in at least a second stage, at least a portion of the sugar not converted in the first stage is oxidized enzymatically by half and, respectively, is reduced enzymatically by the remaining half. 1. A method for obtaining oxidation and reduction products from a mixture of n sugars selected from the group consisting of C5 and C6 sugars , wherein n+a equals the number of oxidation and reduction products obtained by the process , n is at least 2 , and a is at least 1 , wherein at least two of the sugars in the mixture are present at a non-equimolar ratio to each other , the process comprising:in a first stage, enzymatically oxidizing at least one of the sugars which are present at a non-equimolar ratio to each other and, at the same time, enzymatically reducing at least one of the other sugars present at a non-equimolar ratio to each other,wherein, in the first stage, a portion of at least one of the sugars present at a non-equimolar ratio to each other is not converted, andin at least a second stage, enzymatically modifying at least a portion of the sugar not converted in the first stage so as to be oxidized enzymatically by half and, respectively, reduced enzymatically by a remaining half.2. The method of claim 1 , ...

Method for Operating an Internal Combustion Engine of a Motor Vehicle, in Particular a Motor Car

A method for operating an internal combustion engine of a motor vehicle, which has an exhaust gas system that exhaust gas from at least one combustion chamber of the internal combustion chamber can flow through and includes at least one nitrogen oxide storage catalyst, at least one particulate filter, and at least one selective catalytic reduction (SCR) catalyst.

PROCESS FOR THE ENZYMATIC REGENERATION OF REDOX COFACTORS

A process for the enzymatic regeneration of the redox cofactors NAD/NADH and NADP/NADPH in a one-pot reaction, wherein, as a result of at least two further enzymatically catalyzed redox reactions proceeding in the same reaction batch (product-forming reactions), one of the two redox cofactors accumulates in its reduced form and, respectively, the other one in its oxidized form, characterized in that a) in the regeneration reaction which reconverts the reduced cofactor into its original oxidized form, oxygen or a compound of general formula RC(O)COOH is reduced, and b) in the regeneration reaction which reconverts the oxidized cofactor into its original reduced form, a compound of general formula RCH(OH)Ris oxidized and wherein R, Rand Rin the compounds have different meanings. 3. A process according to claim 1 , wherein Rand Rindependently of each other are selected from the group consisting of H claim 1 , (C-C) alkyl claim 1 , wherein alkyl is linear-chain or branched claim 1 , (C-C) alkenyl claim 1 , wherein alkenyl is linear-chain or branched and comprises one to three double bonds claim 1 , aryl claim 1 , C-Caryl claim 1 , carboxyl claim 1 , or (C-C) carboxy alkyl.4. A process according to claim 1 , characterized in that oxidation reaction(s) and reduction reaction(s) take place on the same substrate (molecular backbone).5. A process according to claim 1 , characterized in that oxidation reaction(s) and reduction reaction(s) proceed chronologically parallel.6. A process according to claim 1 , characterized in that claim 1 , in the regeneration reaction which reconverts the oxidized cofactor into its original reduced form claim 1 , 2-propanol is oxidized to acetone by means of an alcohol dehydrogenase.7. A process according to claim 1 , characterized in that claim 1 , in the regeneration reaction which reconverts the reduced cofactor into its original oxidized form claim 1 , pyruvate is reduced to lactate by means of a lactate dehydrogenase.8. A process according ...

PROCESS FOR THE ENZYMATIC REGENERATION OF REDOX COFACTORS

A process for the enzymatic regeneration of the redox cofactors NAD/NADH and NADP/NADPH in a one-pot reaction, wherein, as a result of at least two further enzymatically catalyzed redox reactions proceeding in the same reaction batch (product-forming reactions), one of the two redox cofactors accumulates in its reduced form and, respectively, the other one in its oxidized form, characterized in that a) in the regeneration reaction which reconverts the reduced cofactor into its original oxidized form, oxygen or a compound of general formula RC(O)COOH is reduced, and b) in the regeneration reaction which reconverts the oxidized cofactor into its original reduced form, a compound of general formula RCH(OH)Ris oxidized and wherein R, Rand Rin the compounds have different meanings. 1. A process for the enzymatic regeneration of the redox cofactors NAD/NADH and NADP/NADPH in a one-pot reaction , wherein , as a result of at least two further enzymatically catalysed redox reactions proceeding in the same reaction batch (product-forming reactions) , the redox cofactor NAD/NADH accumulates in its reduced form as NADH and the redox cofactor NADP/NADPH accumulates in its oxidized form as NADP , wherein:a) in the regeneration reaction which reconverts NADH into its original oxidized form, oxygen or pyruvate is reduced by means of an NADH oxidase or a lactate dehydrogenase, and{'sup': '+', 'b) in the regeneration reaction which reconverts NADP into its original reduced form, 2-propanol or malate is oxidized by means of an alcohol dehydrogenase or a malate dehydrogenase.'}2. The process according to claim 1 , wherein oxidation reaction(s) and reduction reaction(s) take place on the same substrate (molecular backbone).3. The process according to claim 1 , wherein oxidation reaction(s) and reduction reaction(s) proceed chronologically parallel.4. The process according to claim 1 , wherein claim 1 , in the regeneration reaction which reconverts NADP+ to NADPH claim 1 , 2-propanol is ...

PROCESS FOR THE CONVERSION OF SUGARS

The present invention relates to a process for the conversion of D-glucose. The process according to the invention comprises a step a) in which part of the D-glucose is enzymatically oxidized to D-gluconic acid (lactone) and a portion of the D-glucose which is essentially equimolar thereto is reduced to D-sorbitol. In addition to D-glucose, D-fructose is also present in the reaction mixture of step a). The process comprises a further step b) in which D-sorbitol formed from the D-glucose in step a) is enzymatically oxidized to D-fructose. 1. A process for the conversion of D-glucose , comprising a step a) in which a part of the D-glucose is enzymatically oxidized to D-gluconic acid (lactone) and a part of the D-glucose which is essentially equimolar thereto is enzymatically reduced to D-sorbitol , wherein , in addition to D-glucose , D-fructose is also present in the reaction mixture of step a) and wherein the process comprises a further step b) in which D-sorbitol formed from the D-glucose in step a) is enzymatically oxidized to D-fructose.2. A process according to claim 1 , characterized in that the reaction mixture is contacted in step a) with a glucose dehydrogenase and a xylose reductase having glucose reductase activity or with another glucose reductase.3. A process according to claim 1 , characterized in that claim 1 , in step b) claim 1 , the D-sorbitol is contacted with a sorbitol dehydrogenase for the enzymatic oxidation claim 1 , whereby D-sorbitol is oxidized to D-fructose.4. A process according to claim 1 , characterized in that the redox cofactor(s) NAD(P)and/or NAD(P)H is/are present in the reaction mixture of step a) and/or in the reaction mixture of step b).5. A process according to claim 1 , characterized in that claim 1 , during the conversion of D-sorbitol to D-fructose claim 1 , a reduced redox cofactor NAD(P)H claim 1 , which has been formed in step b) claim 1 , is enzymatically recycled back to its oxidized starting form continuously and in ...

Method for producing fructose

A method for the enzymatic production of D-fructose from D-glucose in a one-pot synthesis, wherein D-glucose is oxidized enzymatically to D-glucosone and D-glucosone is reduced enzymatically to D-fructose and the use of the D-fructose produced in this way for the production of furan derivatives.

Process for the catalytic conversion of carbon monoxide with steam to form hydrogen and carbon dioxide

Hydrogen and carbon dioxide are produced from steam and carbon monoxide using as catalyst a mixture of a sulphide of cobalt and/or nickel together with one or more sulphides of the transition groups VA, VIA, and VIIA of the Periodic System of Leverenz, used either alone or on a carrier. The catalyst may also contain iron or copper sulphide. The reaction may be at superatmospheric pressure, e.g. 7 to 35 atmospheres and in at least two stages, the mean temperature in each successive stage being 50 DEG to 100 DEG C. lower than that in the preceding stage. The gas to be converted may contain hydrogen sulphide and organic sulphur compounds. The catalyst is re-activated by oxidation and re-sulphurization in situ. Catalyst carriers used may be alumina, synthetic and natural silicates, oxides of magnesium, calcium, zirconium, chromium, titanium.ALSO:In the conversion of steam and carbon monoxide to hydrogen and carbon dioxide a catalyst is used comprising a sulphide of cobalt and/or nickel together with a sulphide of a metal of Group VA, VIA, and VIIA of the Leverenz Periodic system. Examples use 9,8% by weight of molybdenum sulphide, and 4,7% by weight of cobalt sulphide using active alumina as carrier, the catalyst used as cylindrical pellets 3 mm. high and 3 mm. diameter.

Verwendung von copolymerisaten auf basis von langkettigen olefinen und ethylenisch ungesaettigten dicarbonsaeureanhydriden zum hydrophobieren von leder und pelzfellen

Copolymers based on long-chain olefins and ethylenically unsaturated dicarboxylic anhydrides for rendering leathers and skins water-repellent

Copolymers which are obtainable by free radical copolymerization of (a) C 8 --C 40 -monoolefins with (b) ethylenically unsaturated C 4 -C 8 -dicarboxylic anhydrides by mass polymerization at from 80° to 300° C. to give copolymers having molecular weights of from 500 to 20,000 g/mol, subsequent solvolysis of the anhydride groups of the copolymers and partial or complete neutralization of the carboxyl groups formed during the solvolysis, in an aqueous medium by means of a base, and which are present in the form of aqueous dispersions or solutions, are used as agents for rendering leathers and skins water-repellent.

Compositions and methods for oligonucleotide formulations

The present invention relates generally to imrnunostimulatory nucleic acids, compositions thereof and methods of using the imrnunostimulatory nucleic acids. In particular the invention relates to palindrome-containing imrnunostimulatory nucleic acids and the use of these nucleic acids in treating disease.

Reactor para llevar a cabo una reaccion exotermica en la fase de gas.

La invención se relaciona con un reactor para llevar a cabo una reacción exotérmica en la fase gaseosa, el cual comprende un recipiente que tiene una pared (13) externa compuesta de un material metálico, en donde la cubierta (17) interna está dispuesta en el interior del reactor (1) y la cubierta (17) interna está a una distancia de por lo menos 50 mm desde el interior de la pared (13) externa.

Verfahren zur Abdichtung von flüssigkeitsdurchlässigen Bodenschichten oder Klüften und Spalten unter oder neben Kontaminationsherden

Patent DE3300726C2

Assay for detection of chimeric antigen receptor T cells

The invention is directed to a detection reagent for CAR expressing cells according to general formula (1) X n —S m —D o wherein X is a polypeptide comprising at least 20 amino acids of which at least two amino acids are connected by at least one disulfide group S is a spacer comprising at least 15 carbon atoms D is a detection moiety m, o are integers independently between 1 and 200 n is an integer between 4 and 200 with the provisio that X binds to the antigen binding domain of a chimeric antigen receptor of a cell. The detection agent can be used in a method to detect cells having an antigen binding domain of a chimeric antigen receptor (CAR) binding the detection reagent and preferable to remove the detection moiety D from the detected cell.

Solar energy electric or thermal energy converter - has stacked concentrators with fluorescence centres and solar cells each converting part of incident light

Light is collected in a transparent layer (concentrator) whose index of refraction is greater than that of the surrounding medium, and which contains fluorescent centres. The light is then applied to a solar cell (or an absorber). More than one concentrator/solar cell combination is used. The concentrators are separated by a medium with a lower index of refraction than that of a concentrator. They are stacked, so that each concentrator converts a part of the incident spectrum into fluorescent light applies it to a solar cell or an absorber.

Reversible cell detection via mhc with conjugates having an enzymatically cleavable detection moiety

The invention is directed to a Conjugate for labelling a target moiety on a cell, characterized by general formula (II): Xo - P - Ym, with Y : MHC-complex targeting TCR molecules, P : enzymatically degradable spacer, X : detection moiety, o : integer between 5 and 25, m : integer between 2 and 1000, wherein X and P; P and Y are covalently bound to each other and Y is bound to P via the C-terminus.

Process for producing xylitol from lignocellulosic biomass involving a step of alcohol-alkaline delignification

Die Erfindung betrifft ein Verfahren zur Herstellung von Xylitol, gekennzeichnet durch die Kombination der Maßnahmen, dass - lignocellulosisches Material mit einer wässrigen Lösung, welche einen Alkohol, insbesondere einen C 1-4 -Alkohol oder ein Phenol, enthält und einen pH-Wert zwischen 11,0 und 14,0 aufweist, behandelt wird, um Lignocellulose zu spalten, und Spaltprodukte aus dem Material abzutrennen, wobei ein mit Cellulose und Hemicellulose angereichertes Material erhalten wird, - das erhaltene, mit Cellulose und Hemicellulose angereicherte Material mit Xylanase behandelt wird um Xylose zu gewinnen, und - die Xylose enzymatisch zu Xylitol umgewandelt wird. The invention relates to a process for the preparation of xylitol, characterized by the combination of the measures that lignocellulosic material is treated with an aqueous solution containing an alcohol, in particular a C 1-4 -alcohol or a phenol, having a pH between 11.0 and 14.0, to cleave lignocellulose, and cleavage products separated from the material to give a cellulose and hemicellulose-enriched material, the resulting cellulosic and hemicellulose enriched material is treated with xylanase to recover xylose, and - The xylose is enzymatically converted to xylitol.

Process for the production of carbohydrate cleavage products from a lingnocellulosic material

A process for the production of carbohydrate cleavage products, characterized by a combination of the measures that a lignocellulosic material is treated with an aqueous solution containing an alcohol, in particular a C 1-4 -alcohol or a phenol, and having a pH-value of between 11.0 and 14.0 in order to cleave lignocellulose and separate cleavage products from the material, whereby a material enriched with cellulose and hemicellulose is obtained, and the obtained material enriched with cellulose and hemicellulose is treated with at least one carbohydrate-cleaving enzyme in order to obtain the carbohydrate cleavage products.

Elastic clip-on connector element

The contacting device has an electrically conductive contact element that is elastically deformable and is shaped so that it can be fixed in a housing of an electronic device or a carrier as a result of its shape. The contact element has at least one constriction that engages a corresponding opening in the housing.

Roof antenna for a vehicle with improved baseplate and contacting

The invention relates to a roof antenna to be mounted on the roof of a vehicle, comprising a baseplate (1) on which a support plate (10) is fastened. An antenna radiator (9) covered by an antenna cover (14) is disposed at or on the support plate (10). The invention is characterized in that at least one mating contact element (11) which is electrically connected to the at least one antenna radiator (9) is integrated into the baseplate (1). The approximately elongate baseplate (1), on its one end (2), is provided with a detent hook (4), and on the end (3) opposite said end (2), is adapted to receive a fastening element.

Procédé de récupération d'acétate à partir de la lignocellulose

Method for extracting low-molecular lignin (LML)

Extracting low molecular weight lignin (LML) from lignocellulosic material, preferably lignocellulose, comprises treating the lignocellulosic material with an aqueous extracting solution containing an alcohol-content having 1-4C, preferably ethanol or isopropanol having a concentration of 70-95%, preferably 75-85%, at a pH 12-14, where an aqueous solution of LML is obtained.

METHOD AND DEVICE FOR PRODUCING OZONE

Process and apparatus for producing ozone

The invention relates to a process and an apparatus for producing ozone from an oxygen-containing feed gas. In order to achieve a reduction of the operating temperature of the ozone generator 1 and thus an increase in the ozone yield, it is proposed that the oxygen-containing feed gas be cooled with a gas liquefied to a very low temperature. To this end, liquid oxygen from a liquid-oxygen tank 19 is preferably supplied via line 14 to the feeder 5 for the feed gas. <IMAGE>

Iron oxide-chromium oxide catalyst and process for high-temperature co conversion

ABSTRACT Iron oxide-chromium oxide catalyst of increased mechanical strength (lateral crushing strength) for high-temperature water-gas shift reaction. The catalyst contains as an additional component magnesium oxide and/or magnesium spinels in the form of discrete particles.

Hydrocracking process

Process for hydrocracking a petroleum hydrocarbon charge contaminated with nitrogenous compounds, comprising the hydrogenation of said charge in a first reaction zone followed with a separation in two phases, gaseous and liquid, of the resulting hydrogenated product, adding to said liquid phase the effluent from a subsequent prefractionation zone, treating the resulting mixture in a second reaction zone, adding to the effluent of said second reaction zone the above-mentioned gaseous phase, treating the resulting effluent in said prefractionation zone and separating therefrom a liquid fraction, at least one portion of which is recycled to said second reaction zone and a gaseous fraction which, after cooling is separated into a gas of high hydrogen content and a liquid effluent containing products converted in at least one reaction zone, said products being separated by fractionation.

Test device for testing a virtual control device

Hydro cracking of feeds contg. nitrogen - with prior hydro denitrification and high ppressure prefactionation of effluent

Hydro cracking of feeds contg. nitrogen - with prior hydro denitrification and high ppressure prefactionation of effluent

Petroleum hydrocarbon feeds contaminated with N cpds. are hydrocracked by (a) contacting the feed with H2 in the presence of a hydrodesulphurisation, hydrodenitrification or hydrocracking catalyst in a first reactor at 300-550 degrees C (pref. 300-470 degrees C) and 15-250) atm; (b) passing the effluent to a 1st separator at the same pressure and a temp. of 200-300 degrees C (pref. 250-290 degrees C) to obtain an NH3-redn. rich vapour fraction and a liq. effluent contg. 50 ppm NH3; (c) mixing the liq. effluent with at least part of the bottom product from a subsequent prefractionator; (d) passing the mixt. to a 2nd reactor, where it is treated at 300-550 degrees C (pref. 300-440 degrees C) and 15-250 (pref. 50-250) atm; (e) mixing the effluent from the 2nd reactor with the vapour fraction from the 1st reactor; (f) passing the mixt. to a prefractionator at the same press. as in the 2nd reactor, and stripping it with a gas (pref. H2) to obtain a vapour overhead (H2 + products) and a heavy bottom product (heavy products + unconverted feed); (g) recycling at least part of the bottoms to step (c); and (h) cooling the vapour overhead, separating an H2-rich gas, and fractionating the liq. phase to isolate the required products. Since the NH3 formed in the 1st reactor by-passes the 2nd reactor, the latter can be operated with a conventional NH3-sensitive hydrocracking catalyst. The heavy bottom product from the prefractionator is recycled at the same pressure as that in the 2nd reactor, thus reducing energy consumption.

Matrix metalloproteinase inhibitors

Compounds are provided that bind allosterically to the catalytic domain of MMP-13 and comprise a hydrophobic group, first and second hydrogen bond acceptors and at least one, and preferably both, of a third hydrogen bond acceptor and a second hydrophobic group. Cartesian coordinates for centroids of the above features are defined in the specification. When the ligand binds to MMP-13, the first, second and third (when present) hydrogen bond acceptors bond respectively with Thr245, Thr 247 and Met 253, the first hydrophobic group locates within the S1′ channel of MMP-13 and the second hydrophobic group (when present) is relatively open to solvent. The compounds specifically inhibit the matrix metalloproteinase-13 enzyme and thus are useful for treating diseases resulting from tissue breakdown, such as heart disease, multiple sclerosis, arthritis, atherosclerosis, and osteoporosis.

HYDRAULIC BRAKE WITH EXTERNAL STRENGTH, WITH TWO CIRCUITS

FREIN AVEC DEUX SOUPAPES COMMANDEES PAR DES POUSSOIRS PLACES DE PART ET D'AUTRE D'UN FLEAU DE BALANCE, L'UN DES POUSSOIRS ETANT ASSISTE D'UN PISTON. LA PEDALE 10 AGIT SUR LES POUSSOIRS 17, 18 PAR LE DISPOSITIF ELASTIQUE 11 ET LE FLEAU DE BALANCE 14. LES POUSSOIRS APPARTIENNENT A DEUX SOUPAPES 8 ET 9 ALLANT AUX FREINS DE ROUE 31, 32. POUR OBTENIR UNE PRESSION DIFFERENTE ENTRE LES CIRCUITS 1 ET II, ON A ADJOINT AU POUSSOIR 17 UN PISTON NON VISIBLE SUR LA FIGURE, PARALLELE AU POUSSOIR 17, S'APPUYANT AU FLEAU 14 DU MEME COTE QUE LE POUSSOIR 17 ET SOUMIS A LA PRESSION DE LA CHAMBRE DE SOUPAPE 25. BRAKE WITH TWO VALVES CONTROLLED BY PUSHBUTTONS PLACED ON EACH OTHER OF A BALANCE BOOM, ONE OF THE TAPPETS ASSISTED BY A PISTON. THE PEDAL 10 ACTS ON THE TAPPETS 17, 18 BY THE ELASTIC DEVICE 11 AND THE BALANCE BOLT 14. THE TAPPETS BELONG TO TWO VALVES 8 AND 9 GOING TO THE WHEEL BRAKES 31, 32. TO OBTAIN A DIFFERENT PRESSURE BETWEEN CIRCUITS 1 AND II, A PISTON NOT VISIBLE IN THE FIGURE, PARALLEL TO THE PUSHBUTTON 17, BEING SUPPORTED BY THE BUMPER 14 ON THE SAME SIDE AS THE TAPPET 17 AND SUBJECTED TO THE PRESSURE OF THE VALVE CHAMBER 25.

OUTER RING OF WHEEL BEARING.

Bague extérieure d'un palier de roue, cette bague présentant dans son alésage au moins une surface de portée (7, 8) et possédant une partie manchon (15) dotée d'une partie bride (17) présentant une surface frontale du côté intérieur et, pour des vis de fixation, des trous filetés débouchant directement dans une dépression radiale (27). Chaque dépression (27) de la partie manchon (15) a) présente des contours (31) qui, en coupe longitudinale, sont concaves et se raccordent à la surface frontale (19) de la partie bride (17) à la surface périphérique (16) de la partie manchon (15); b) est disposée sensiblement au-dessus d'une surface de portée (7, 8) de la bague extérieure (1); et c) est réalisée par un procédé de formage par roulage et/ou par refoulement, comprimant la matière de la bague extérieure (1) en direction de la surface de portée (7,8). Outer ring of a wheel bearing, said ring having in its bore at least one bearing surface (7, 8) and having a sleeve portion (15) having a flange portion (17) having a front surface on the inner side and, for fixing screws, threaded holes opening directly into a radial depression (27). Each depression (27) of the sleeve portion (15) a) has contours (31) which, in longitudinal section, are concave and connect to the front surface (19) of the flange portion (17) at the peripheral surface ( 16) of the sleeve portion (15); b) is disposed substantially above a bearing surface (7, 8) of the outer ring (1); and c) is carried out by a rolling and / or repressing forming process, compressing the material of the outer ring (1) towards the bearing surface (7, 8).

Hydro cracking of feeds contg. nitrogen - with prior hydro denitrification and high ppressure prefactionation of effluent

Petroleum hydrocarbon feeds contaminated with N cpds. are hydrocracked by (a) contacting the feed with H2 in the presence of a hydrodesulphurisation, hydrodenitrification or hydrocracking catalyst in a first reactor at 300-550 degrees C (pref. 300-470 degrees C) and 15-250) atm; (b) passing the effluent to a 1st separator at the same pressure and a temp. of 200-300 degrees C (pref. 250-290 degrees C) to obtain an NH3-redn. rich vapour fraction and a liq. effluent contg. 50 ppm NH3; (c) mixing the liq. effluent with at least part of the bottom product from a subsequent prefractionator; (d) passing the mixt. to a 2nd reactor, where it is treated at 300-550 degrees C (pref. 300-440 degrees C) and 15-250 (pref. 50-250) atm; (e) mixing the effluent from the 2nd reactor with the vapour fraction from the 1st reactor; (f) passing the mixt. to a prefractionator at the same press. as in the 2nd reactor, and stripping it with a gas (pref. H2) to obtain a vapour overhead (H2 + products) and a heavy bottom product (heavy products + unconverted feed); (g) recycling at least part of the bottoms to step (c); and (h) cooling the vapour overhead, separating an H2-rich gas, and fractionating the liq. phase to isolate the required products. Since the NH3 formed in the 1st reactor by-passes the 2nd reactor, the latter can be operated with a conventional NH3-sensitive hydrocracking catalyst. The heavy bottom product from the prefractionator is recycled at the same pressure as that in the 2nd reactor, thus reducing energy consumption.

Improvements to magnetic memories

Manufacture of silicone oils

Adjustable multiway EM valve for vehicle working cylinders - has electromagnet housing fitting either way up to valve housing

The valve has an armature (25) biased in one direction by a spring and moved in the opposite direction by a magnetic force, the armature movement operating the valve element (3) via an operating rod (19) projecting from the valve housing (1). The housing (23) containing the electro magnet (10) and the armature (25) can be fitted to the valve housing (1) either way up. A relief chamber (8') for the valve (2) is incorporated in the valve housing (1) on the side to which the electro magnet housing (23) is fitted. Pref the valve comprises a 3/2 way valve for operating working cylinders with pressurised air, e.g. in a vehicle.

Device for progressive regulation of rotation speeds

organopolysiloxane emulsions

ADJUSTABLE MOTOR SUPPORT FOR AUTOMOTIVE MOTOR

CE SUPPORT 1 SERT A ISOLER LES VIBRATIONS DU BLOC-MOTEUR DE LA CARROSSERIE D'UN VEHICULE. LE DEGRE D'AMORTISSEMENT ET LA CARACTERISTIQUE DE SUSPENSION DE CE SUPPORT SONT REGLES A L'AIDE DE SIGNAUX DE COMMANDE D'UNE UNITE DE COMMANDE ELECTRONIQUE 41. POUR LE REGLAGE DE L'AMORTISSEMENT, LE SUPPORT COMPORTE UN ORGANE DE MANOEUVRE 29, RELIE A L'UNITE DE COMMANDE 41, POUR LE REGLAGE D'UNE SECTION D'ETRANGLEMENT 32 ENTRE UNE PREMIERE CHAMBRE 21 ET UNE SECONDE CHAMBRE 22 D'UN ESPACE D'AMORTISSEMENT 15. LA CARACTERISTIQUE DE SUSPENSION EST REGLABLE A L'AIDE D'UN COUSSIN D'AIR 16 QUI PEUT ETRE ALIMENTE EN AIR COMPRIME OU DETENDU AU MOYEN D'UN DISTRIBUTEUR 37. L'UNITE DE COMMANDE 41 RECOIT DES SIGNAUX D'ENTREE 51 A 59 DE CAPTEURS DE GRANDEURS AGISSANT SUR LE MOUVEMENT DU BLOC-MOTEUR PAR RAPPORT A LA CARROSSERIE. THIS BRACKET 1 IS USED TO ISOLATE THE VIBRATIONS OF THE MOTOR BLOCK FROM THE BODY OF A VEHICLE. THE DEGREE OF CUSHIONING AND THE SUSPENSION CHARACTERISTICS OF THIS BRACKET ARE ADJUSTED BY THE CONTROL SIGNALS OF AN ELECTRONIC CONTROL UNIT 41. FOR THE ADJUSTMENT OF THE CUSHIONING, THE BRACKET INCLUDES AN OPERATOR 29, CONNECTED AT THE CONTROL UNIT 41, FOR THE ADJUSTMENT OF A THROTTLE SECTION 32 BETWEEN A FIRST CHAMBER 21 AND A SECOND CHAMBER 22 OF A CUSHIONING SPACE 15. THE SUSPENSION CHARACTERISTIC IS ADJUSTABLE USING AN AIR CUSHION 16 WHICH CAN BE SUPPLIED WITH COMPRESSED OR EXPANDED AIR BY MEANS OF A DISTRIBUTOR 37. THE CONTROL UNIT 41 RECEIVES INPUT SIGNALS 51 TO 59 FROM SENSORS ACTING ON THE MOVEMENT OF THE MOTOR BLOCK IN RELATION TO THE BODYWORK.

Matrix metalloproteinase inhibitors

Compounds are provided that bind allosterically to the catalytic domain of MMP-13 and comprise a hydrophobic group, first and second hydrogen bond acceptors and at least one, and preferably both, of a third hydrogen bond acceptor and a second hydrophobic group. Cartesian coordinates for centroids of the above features are defined in the specification. When the ligand binds to MMP-13, the first, second and third (when present) hydrogen bond acceptors bond respectively with Thr245, Thr247 and Met 253, the first hydrophobic group locates within the S1' channel of MMP-13 and the second hydrophobic group (when present) is relatively open to solvent. The compounds specifically inhibit the matrix metalloproteinase-13 enzyme and thus are useful for treating diseases resulting from tissue breakdown, such as heart disease, multiple sclerosis, arthritis, atherosclerosis, and osteoporosis.

MOUNTING OF THE BEARING OF A SHAFT CARRYING A SPROCKET INSIDE A CRANKCASE.

The shaft (10) is mounted by using a double-row rolling bearing in a throughbore (11) of a housing (12). The rolling bearing has an outer race ring (14) with two outer raceways (15, 16) and a radially outwardly extending flange (20). A cover (26) is secured with an annular flange (27) on an end face (25) of the flange. At least one oil hole (29) is incorporated between the two outer raceways. To ensure that the raceway (15) can be positioned rigidly in the throughbore, the outer race ring (14) has an outer curved surface portion (33) adjoining the outside end face (25) on which an inner surface (35) of a centring projection (34) of the cover (26) is tightly fitted. Each oil hole (29) is disposed between the end face (25) and the portion (33) and opens into a radially extending connecting passage (42, 49) disposed between the flange and the annular flange (27).

Method of obtaining acetate from lignocellulose specification identification

A method of obtaining an aqueous solution of an alkali acetate from lignocellulose, wherein lignocellulose is treated with a first aqueous extraction solution having a pH value in the range of 12 to 14 and a content of a C 1-4 alcohol, in particular ethanol or isopropanol, in the range of 40% to 90%, in particular of from 75% to 85%, whereby a first aqueous solution of an alkali acetate is obtained, and wherein said first solution of an alkali acetate is used to treat additional lignocellulose in order to enrich additional acetate in said first solution.

Arrangement and method for damping of a piston movement

Arrangement for damping of a piston movement in a compressed air cylinder (10; 20), which arrangement comprises - a compressed air cylinder (10; 20), - a valve device, - a compressed air device, and - a control unit, which arrangement is characterised in that the control unit comprises means for controlling the valve devices in such a way that the movement of the piston (12; 22) is damped before it reaches the casing of the compressed air cylinder. The invention relates also to a method for control of said arrangement.

Catalyst for the synthesis of alcohol mixtures containing methanol and higher alcohols

ABSTRACT OF THE DISCLOSURE A process for the synthesis of an alcohol mixture, including methanol and higher alcohols of fuel quality involves passing a synthesis gas mixture of carbon oxides and hydrogen at a temperature of about 250-400°C and a pressure in the range of from about 80-150 bar over a special catalyst. The catalyst consists of the oxides of copper and zinc in intimate association with each other and a promotional amount of a compound selected from the group consisting of chromium, cerium, lanthanum, manganese, thorium and alkali metals. The catalyst can be made by coprecipitation of two or more of the constituents from a solution of soluble salts to produce an insoluble precipitate, followed by calcination of the insoluble salts to the oxides at temperatures in the range of 350 to 450°C. Alternately, the catalytically active oxides can be obtained by the thermal decomposition of soluble salts from ammine complexed to produce intimately associated oxides. The catalytically active oxides are tableted and can be further impregnated in one or more steps by one or more of the promoting metal oxides. The alcohols produced by this process can be used for fuel or can be mixed with gasoline. Due to the higher alcohols the gasoline and alcohol mixture does not undergo phase separation in the presence of small amounts of water. It is also possible to separate the various alcohols by fractionationand use them as starting material for chemical intermediates.

Apparatus for storing self-heating radioactive materials

Self heating radioactive materials, especially irradiated fuel elements, are stored by using dry storage in which the stored material is arranged enclosed vertically in containers. A better cooling effect is attained if the receptions positions in the storage support is arranged horizontally.

Method for automatic display of possible connections and automatic connection of model components of a model of a technical system

A method for automatic connection of model components of a model of a technical system on a computer with a display, wherein the model has a first model component and a second model component. The first model component and the second model component each have at least one hierarchy element, wherein a hierarchy element contains no hierarchy element, or one hierarchy element, or multiple hierarchy elements. A hierarchy element has no port, or one port, or multiple ports, wherein a hierarchy element and a port have an identifier. A connection between two ports represents an assignment in the technical system. A first set of hierarchy elements and/or ports and a second set of hierarchy elements and/or ports is selected through a graphical user action, wherein a possible assignment is tested for a first port of the first set and a second port of the second set. A possible assignment is present if, for the first port and the second port, and ascending from the first port and the second port in accordance with the hierarchy, the identifiers of the hierarchy elements that are at a higher level than the first port and the second port each correspond at equal hierarchy levels up to a predefinable number of hierarchy levels starting from the port, or are evaluated as corresponding in accordance with a predefined rule. If a possible assignment is present, the possible assignment is displayed and/or the first port of the first set is automatically connected to the second port of the second set.

Method for operating an exhaust gas system of a motor vehicle, and exhaust gas system for an internal combustion engine of a motor vehicle

A method for operating an exhaust gas system of a motor vehicle involves performing regeneration of the particle filter as a function of at least one aging value characterizing an aging condition of the oxidation catalytic converter.

A method for sealing off grounds sites

The invention pertains to a process for sealing off ground sites (1), in particular a waste dump, abandoned dumping grounds, pipelines or the like, or also still be excavated construction sites, using sealants, wherein a fully course-controlled boring technique is used to drive at least one bore (2) underneath the ground site (1) from the surface outside the ground site (1) and the sealant is injected into the soil surrounding the bore (2). To implement the process, jets for injecting the sealant into the soil are mounted on the steerable remote-controlled boring head.

Production of organo-silicon compounds

IN A PROCESS FOR PRODUCTION OF AN ORGANO-SILICON COMPOUND BY THE ADDITION OF A HYDROGEN-SILANE OR -SILOXANE TO AN OLEFINICALLY-UNSATURATED ORGANIC COMPOUND IN THE PRESENCE OF A CATALYST, THE CATALYST ACCORDING TO THE INVENTION IS HEXAMETHYL-DIPYRIDNNE-DIPLATINUM DIIODIDE OF THE FORMULA 1,3-DI(PYRIDINO),1,1,1,3,3,3-HEXA(CH3-)-1,3,2,4- CYCLODIPLATINUMDIIODIDE

Aromatic keto-acids and their derivatives as inhibitors of matrix metalloproteinases

Aromatic keto-acid compounds of formula (I) and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubital ulcers, wound healing, cancer, arthritis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes. Ar, Y, W, R1-R4, n are as defined in the application.

PIRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE

Se describen compuestos de la fórmula I, incluso sus estereoisómeros, isómeros geométricos, tautómeros, solvatos, metabolitos y sales farmacéuticamente aceptables, que son de utilidad en la modulación de la señalización de las quinasas relacionadas con PIKK, por ejemplo, mTOR y para el tratamiento de enfermedades (por ejemplo, cáncer) que son mediadas al menos en parte por la desregulación de la vía de señalización de PIKK (por ejemplo, mTOR). Compounds of the formula I are described, including their stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts, which are useful in modulating the signaling of PIKK-related kinases, for example, mTOR and for the treatment of diseases (for example, cancer) that are mediated at least in part by deregulation of the PIKK signaling pathway (for example, mTOR).

Heteroaryl pyridone and aza-pyridone compounds as inhibitors of btk activity

Heteroaryl pyridone and aza-pyridone compounds of Formula I are provided, where one or two of X 1 , X 2 , and X 3 are N, and including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Method for the production of furan derivatives from glucose

Disclosed is a method for obtaining furan derivatives from D-glucose. In said method, A) D-glucose is transformed into D-fructose in an enzymatic process in which redox cofactors are used and regenerated, one of the two redox cofactors being obtained in the reduced form thereof and the other redox cofactor being obtained in the oxidized form thereof as a result of at least two additional enzymatically catalyzed redox reactions taking place in the same reaction batch, D-glucose being transformed into D-fructose with the aid of two or more oxidoreductases, and B) D-fructose is converted into furan derivatives. The use of furan derivatives produced in said manner is also disclosed.

Applicator device for viscous materials

An applicator device is provided, particularly for solvent-containing and solvent-free UV printing inks, paints or adhesives onto a pattern roller of a flexographic printing machine, which receives the medium in recesses and transfers same to a high pressure roller. To avoid the occurrence of air bubbles in the medium to be applied and to press air out of the emptied recesses before they are filled again, a housing adapted to the lengths of the pattern roller and a dosing roller with elastic surface is provided above the contact line between the dosing roller and the pattern roller, which creates a chamber for accepting the medium located above the contact line of the two rollers and seals the chamber at all sides in a gas and air-tight manner.

Method for producing lignin derivatives

Method for producing lignin derivatives from technical lignins by treatment with proteolytic enzymes (proteases), characterized in that the proteolytic treatment of the technical lignins significantly decreases the molecular mass thereof.

Catalyst and process for the synthesis of methanol and alcohol mixtures containing higher alcohols

ABSTRACT Catalyst for the synthesis of alcohol mixtures containing methanol and higher aliphatic alcohols from CO and H2, which contains, as an oxide precursor, a) copper oxide and zinc oxide, which can be transformed into the catalytically active state by reduction with hydrogen, b) aluminum oxide as a thermostabilizing substance and c) at least one alkali carbonate or alkali oxide, the oxidic precursor comprising from 20 to 70% of the total volume of pores having a diameter between 14 and 7.5 nm, the alkali content being 13 - 130x10-6 gram atom alkali metal per gram of the oxidic precursor, and the aluminum oxide component having been obtained from a colloidally dispersed aluminum hydroxide gel or sol.

New masses of organopolysiloxanes transforming into elastomers under the action of water

PROCESS FOR HYDROPHOBIZATION OF LEATHER AND HAIR SKINS FOR THE APPLICATION OF COPOLYMERS BASED ON COMPRESSED CHAIN OLEFINS AND ETHYLENICALLY INSATURATED DICARBOXYLIC ANIDRIDES

Aromatic keto-acids and their derivatives as inhibitors of matrix metalloproteinases

A jelen találmány tárgyát az (I) általános képletű aromásketosavvegyületek, azok származékai és azok előállítására szolgálóeljárások képezik, továbbá a találmány az ezeket a vegyületeketvalamely gyógyszerészetileg elfogadható hatóanyaggal együtt tartalmazógyógyszerkészítményekre és gyógyszerészeti kezelési eljárásokravonatkozik. A jelen találmány szerinti új vegyületek a mátrixmetalloproteinázok, különösen az A zselatinázok (72 kDa zselati- náz)és a stromelizin-1 gátlására alkalmas inhibitorok. Még közelebbről, ajelen találmány szerinti új vegyületek alkalmasak a sclerosismultiplex, az atherosclerotikus plakk ruptura, aorta aneurisma,szívműködési zavar, restenosis, periodontalis betegség, szaruhártya-fekélyesedés, égési sérülések kezelése, felfekvéses fekély, sebgyó-gyulás, daganat, ízületi gyulladás és egyéb, a fehérvérsejtekszövettámadásától függő autoimmun vagy gyulladásos betegségekgyógyítására. ŕ The present invention relates to aromatic keto acid compounds of the formula I, their derivatives and processes for their preparation, and to pharmaceutical compositions containing them and a pharmaceutically acceptable active ingredient and methods of pharmaceutical treatment. The novel compounds of the present invention are inhibitors of matrix metalloproteinases, in particular Gelatinases A (72 kDa gelatinase) and stromelysin-1. More particularly, the novel compounds of the present invention are useful in the treatment of sclerosismultiplexes, atherosclerotic plaque rupture, aortic aneurysm, cardiac dysfunction, restenosis, periodontal disease, corneal ulcer, burn injury, ulcerative ulcer, ulcerative edema, for the treatment of autoimmune or inflammatory diseases dependent on white blood cell tissue attack. ŕ

8-fluorophthalazin-1(2H)-one compounds

8-Fluorophthalazin-1(2h)-one compounds of Formula II where one or two of X 1 , X 2 , and X 3 are N, are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula II for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Heteroaryl pyridone and aza-pyridone compounds as inhibitors of btk activity

Use of copolymers based on long-chain olefins and ethylenically unsaturated dicarboxylic anhydrides for rendering leathers and skins water-repellent

Use of copolymers obtainable by free-radical copolymerisation of (a) C8-C40-monoolefins with (b) ethylenically unsaturated C4-C8-dicarboxylic anhydrides in the manner of a mass polymerisation at from 80 to 300 DEG C to form copolymers having molecular weights of from 500 to 20,000 g/mol, subsequent solvolysis of the anhydride groups of the copolymers and at least partial neutralisation in an aqueous medium with bases of the carboxyl groups formed in the course of the solvolysis and which are present in the form of aqueous dispersions or solutions, as agents for waterproofing leathers and pelt furs.

Reversible cell detection via mhc with conjugates having an enzymatically cleavable detection moiety

The invention is directed to a Conjugate for labelling a target moiety on a cell, characterized by general formula (II): Xo-P-Ym, with Y: MHC-complex targeting TCR molecules, P: enzymatically degradable spacer, X: detection moiety, o: integer between 5 and 25, m: integer between 2 and 1000, wherein X and P; P and Y are covalently bound to each other and Y is bound to P via the C-terminus.

HYDRAULIC BRAKE SYSTEM, ESPECIALLY FOR MOTOR VEHICLES

Heteroaryl pyridone and aza-pyridone compounds as inhibitors of btk activity

Un compuesto seleccionado del grupo que consiste en: 2-{4-hidroximetil-1'-metil-5'-[5-(4-oxetan-3-il-piperazin-1-il)-piridin-2-ilamino]-6'-oxo-1',6'-dihidro-[3,3']bipiridinil-5-il}-7,7-dimetil-3,4,7,8-tetrahidro-2H,6H-ciclopenta[4,5]pirrolo[1,2-a]pirazin-1-ona, que tiene la estructura **Fórmula** 2-{3'-hidroximetil-1-metil-5-[5-(4-oxetan-3-il-piperazin-1-il)-piridin-2-ilamino]-6-oxo-1,6-dihidro-[3,4']bipiridinil-2'-il}-7,7-dimetil-3,4,7,8-tetrahidro-2H,6H-ciclopenta[4,5]pirrolo[1,2-a]pirazin-1-ona, que tiene la estructura **Fórmula** 2-[3'-hidroximetil-1-metil-5-(5-metil-4,5,6,7-tetrahidro-pirazolo[1,5-a]pirazin-2-ilamino)-6-oxo-1,6-dihidro-[3,4']bipiridinil-2'-il]-7,7-dimetil-3,4,7,8-tetrahidro-2H,6H-ciclopenta[4,5]pirrolo[1,2-a]pirazin-1-ona, que tiene la estructura **Fórmula** 2-[3'-hidroximetil-1-metil-6-oxo-5-(pirimidin-4-ilamino)-1,6-dihidro-[3,4']bipiridinil-2'-il]-7,7-dimetil-3,4,7,8-tetrahidro-2H,6H-ciclopenta[4,5]pirrolo[1,2-a]pirazin-1-ona, que tiene la estructura **Fórmula** 2-[4-hidroximetil-1'-metil-5'-(5-metil-4,5,6,7-tetrahidro-pirazolo[1,5-a]pirazin-2-ilamino)-6'-oxo-1',6'-dihidro-[3,3']bipiridinil-5-il]-7,7-dimetil-3,4,7,8-tetrahidro-2H,6H-ciclopenta[4,5]pirrolo[1,2-a]pirazin-1-ona, que tiene la estructura **Fórmula** 2-{3'-hidroximetil-1-metil-5-[5-((R)-2-metil-4-oxetan-3-il-piperazin-1-il)-piridin-2-ilamino]-6-oxo-1,6-dihidro-[3,4']bipiridinil-2'-il}-7,7-dimetil-3,4,7,8-tetrahidro-2H,6H-ciclopenta[4,5]pirrolo[1,2-a]pirazin-1-ona, que tiene la estructura **Fórmula** 2-{5-[5-((2S,5R)-2,5-dimetil-4-oxetan-3-il-piperazin-1-il)-piridin-2-ilamino]-3'-hidroximetil-1-metil-6-oxo-1,6-dihidro-[3,4']bipiridinil-2'-il}-7,7-dimetil-3,4,7,8-tetrahidro-2H,6H-ciclopenta[4,5]pirrolo[1,2-a]pirazin-1-ona, que tiene la estructura **Fórmula** 2-[3'-hidroximetil-1-metil-5-(5-oxetan-3-il-4,5,6,7-tetrahidro-pirazolo[1,5-a]pirazin-2-ilamino)-6-oxo-1,6-dihidro-[ ...

CATALYST FOR SYNTHESIS OF ALCOHOL MIXTURES CONTAINING METHANOL AND HIGHER ALCOHOLS

Benzothiopyrano(4,3,2,-cd)indazoles, their pharmaceutical compositions and methods for their production

Benzothiopyrano(4,3,2,-cd)indazoles, their pharmaceutical compositions and methods for their production

Water-soluble dyestuffs

ABSTRACT OF THE DISCLOSURE The novel water-soluble disazo dyestuffs consists of two monoazo dyestuff moleties each containing as diazo component an amine of the benzene or naphthalene series and as coupling component an amino-naphthol-mono- or disulfonic acid. The two moieties are bonded to each other via a triazine radical carrying a halogen atom, a sulfonic acid group or a thio ether or oxygen ether group and is bound to the amino groups of the coupling components and the diazo components contain a fiber-reactive radical of the vinyl sul-fone series. To produce the dyestuffs 2 mols of the diazo component carrying the fiber-reactive radical of the vinyl sulfone series is coupled with 1 mol of a bivalent coupling component consisting of 2 radicals of the aminonaphthol bound to the triazine ring via the amino groups, or two monoazo dyestuffs each synthesized from the aforesaid diazo component and an aminonaphthol coupling component are reacted with a 1,3-dihalogeno-triazine containing in 5-position a further halogen atom, a sulfonic acid group, a thio ether, or an oxygen ether group. The metal-free dyestuffs, can be transformed into the correspond-ing heavy metal complex dyestuffs, preferably copper, cobalt and chromium com-plex dyestuffs, by treatment with an agent donating a heavy metal cation. The novel dyestuffs are excellently suitable for dyeing and printing fiber mate-rial of natural and regenerated cellulose and natural, regenerated and synthet-ic polyamides. They are distinguished by clear shades, high tinctorial strength, a very good uptake from a long liquor and a good color-build up. The dyeings obtained therewith have a high fastness to processing and in use.

Matrix metalloproteinases sulfonamide inhibitors

Pneumatic actuator, and system and method for controlling the same

The present invention relates to a pneumatic actuator comprising a cylinder and a piston arranged to reciprocate within said cylinder, said piston dividing said cylinder into a first space having a first port for passing a first gaseous medium into said first space, and a second space having a second port for passing a second gaseous medium into said second space, so as to move said piston, wherein said first gaseous medium is arranged to be provided as a first set of pulses, and said second gaseous medium is arranged to be provided as a second set of pulses, said sets being arranged to provide an impact difference for moving said piston, and at least one position sensor arranged at said pneumatic actuator to sense the position of the piston, said control of the pneumatic actuator being based upon the position of the piston. The present invention also relates to a system for controlling a pneumatic actuator. The present invention also relates to method for controlling a pneumatic actuator. The present invention also relates to a computer programme and computer programme product.

Heteroaryl pyridone and aza-pyridone compounds as inhibitors of btk activity

Pyridone and aza-pyridone compounds and methods of use

Assay for detection of chimeric antigen receptor t cells

The invention is directed to a detection reagent for CAR expressing cells according to general formula (1)          X n -S m -D o wherein - X is a polypeptide comprising at least 20 amino acids of which at least two amino acids are connected by at least one disulfide group - S is a spacer comprising at least 15 carbon atoms - D is a detection moiety - m, o are integers independently between 1 and 200 - n is an integer between 4 and 200 with the provisio that X binds to the antigen binding domain of a chimeric antigen receptor of a cell. The detection agent can be used in a method to detect cells having an antigen binding domain of a chimeric antigen receptor (CAR) binding the detection reagent and preferable to remove the detection moiety D from the detected cell.

Electric installation device with structure frame and operating or function element

The device (1) has a base device mountable in a standard flush-mounting box and connectable with an operating- or functional- element (25) by a carrier frame (3). The operating- or functional- element stands in engagement with a locking element (16) of the frame by a lock hook (28). The hook is rigidly formed when the locking element is transversely, spring-subjected and parallel moveable to a front surface/back surface of the carrier frame. The locking element is pressed in a direction of a front wall surrounding the carrier frame. The operating- or functional- element is designed as a joystick, touch screen, loudspeaker or a microphone.

N-substituted benzamides and their use in the treatment of pain

The invention provides novel compounds having the general formula (I) and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, B, R1, R2, R3, R4, R5 and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Tetrahydro-pyrido [3,4-b] indoles as estrogen receptor modulators and their uses

Anti-CD8 antibody which binding is Ca2+ dependent

The present invention provides for a method for generating a metal ion binding protein, the method comprising a) integrating the amino acid sequence DDD into CDR1 of a light chain variable region of an antibody or fragment thereof; and b) combining the sequence of step a) with a heavy chain variable region of an antibody or fragment thereof; and c) isolating the protein. Also provided is the use of metal ion binding proteins generated by the method of the present invention for isolation and purification of proteins and for the reversible labeling of a target molecule. Also provided is a metal ion binding anti-CD8 protein.

Sandwich and process for making the same

Heteroaryl estrogen receptor modulators and uses thereof

Described herein are heteroaryl compounds with estrogen receptor modulation activity or function having the Formula (I), (II), and (III) structures: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I, II, and III compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Method for influencing the bus communication of a electronical control unit

Push button switch with momentary jump mechanism