Polyurethane Dispersions and Methods of Making and Using Same

The presently disclosed and claimed inventive concept(s) relates generally to polyethylene terephthalate (“PET”) polymers, digested oligomeric derivatives of PET (“dPET”), functionalized oligomeric derivatives of dPET (“dfPET”), and polyurethane dispersions (“PUD”) made from or incorporating dfPET therein.

High performance resilient skate wheel with compression modulus gradient

A high performance resilient skate wheel ( 100 ) including a solid core tire ( 102 ) and a hub ( 104 ) defining a bearing axis. The solid core tire ( 102 ) includes an inner ring ( 106 ) and an outer tire material ( 108 ) disposed about the inner ring and forming a rolling surface of the wheel. The outer tire material ( 108 ) is harder than the inner ring ( 106 ). The inner ring ( 106 ) has a stepped profile in cross section, defining a middle portion disposed axially between lateral portions of the inner ring, with the middle portion having a greater outer diameter than the lateral portions. Making the solid core skate wheel ( 100 ) includes providing a hub assembly having an inner ring ( 106 ) with a stepped profile in cross section disposed about a wheel hub ( 104 ), and over molding the inner ring with a tire material ( 108 ) forming a rolling surface of the wheel.

Subsea casing drilling system

In one embodiment, a casing bit drive assembly may be used with a casing drilling system. The casing bit drive assembly may include one or more of the following: a retrievable drilling motor; a decoupled casing sub; a releasable coupling between the motor and casing bit; a releasable coupling between the motor and casing; a cement diverter; and a casing bit.

Electromagnetic shield for a passive electronic component in an active medical device implantable lead

A shielded component or network for an active medical device (AMD) implantable lead includes (1) an implantable lead having a length extending from a proximal end to a distal end, all external of an AMD housing, (2) a passive component or network disposed somewhere along the length of the implantable lead, the passive component or network including at least one inductive component having a first inductive value, and (3) an electromagnetic shield substantially surrounding the inductive component or the passive network. The first inductive value of the inductive component is adjusted to a account for a shift in its inductance to a second inductive value when shielded.

Arbitration method for multi-request display pipeline

Embodiments of an apparatus and method are disclosed that may allow for arbitrating multiple read requests to fetch pixel data from a memory. The apparatus may include a first and a second processing pipeline, and a control unit. Each of the processing pipelines may be configured to generate a plurality of read requests to fetch a respective one of a plurality of portions of stored pixel data. The control unit may be configured to determine a priority for each read request dependent upon display coordinates of one or more pixels corresponding to each of the plurality of portions of stored pixel data, and determine an order for the plurality of read requests dependent upon the determined priority for each read request.

Method for Estimating Pressure Gradients and Fractional Flow Reserve from Computed Tomography Angiography: Transluminal Attenuation Flow Encoding

An embodiment in accordance with the present invention provides a method for non-invasively determining the functional severity of coronary artery stenosis. The method includes gathering patient-specific data related to concentration of a contrast agent within a coronary artery of a patient using a coronary computed tomography angiography scan (CCTA). The patient-specific data is used to calculate a patient-specific transarterial attenuation gradient for the coronary artery of the patient. The patient specific transarterial attenuation gradient is compared to previously collected data to determine an estimate of a pressure gradient and/or fractional flow reserve (FFR) for the patient. As more data is collected, the data can be added to the database in order to increase the accuracy of future assessments. The database can also be enhanced by adding data generated by canonical models and mathematical analysis.

Method and apparatus for sealing tubulars

A method of controlling fluid flow between two tubulars includes disposing a sealing member in an annular area between two tubulars, wherein the two tubulars partially overlap; moving the sealing member to a lower position where it is not in contact with one of the tubulars, thereby allowing fluid flow through the annular area; and moving the sealing member to an upper position where it is in contact with both of the tubulars, thereby preventing fluid flow through the annular area.

Tachometer for downhole drilling motor

A tachometer for a downhole motor includes: a tubular housing having a coupling for connection to a housing of the motor; and a probe. The probe: has a coupling for connection to a rotor of the motor, is movable relative to the tachometer housing, and has at least a portion disposed in a bore of the tachometer housing. The tachometer further includes electronics disposed in the tachometer housing and including: a battery; one or more proximity sensors for tracking an orbit of the probe; and a programmable logic controller (PLC). The PLC is operable: to receive the tracked orbit, and at least one of: to determine an angular speed of the probe using the tracked orbit, and to forecast a remaining lifespan of the motor using the tracked orbit.

Mass-airflow measurement conversion apparatus for internal combustion engine carburetors

A mass air flow measurement apparatus for an internal combustion engine includes: a plurality of pressure sensors disposed at different locations along an air intake path of the internal combustion engine, each pressure sensor adapted to sense a pressure of air flowing into the internal combustion engine and output an electrical signal as a pressure signal corresponding to the sensed air pressure; a carburetor having a plurality of booster venturis, the carburetor rendered permanently inoperable to mix fuel with air flowing in the air intake path, a body of the carburetor configured to accept one or more of the plurality of pressure sensors for each of the plurality of booster venturis; and a calculation section that receives the pressure signals and generates a mass air flow signal as an output signal to an engine management system to control an electronic fuel injection system based on the received pressure signals.

Near belly-tangent pod system for an aircraft

A pod system for an aircraft is disclosed. Embodiments provide an external, near belly-tangent modular plug-and-play pod system that includes a scalable set of left-side bays which are connected to a scalable set of right-side bays via a central compartment positioned on a bottom external surface of the aircraft's fuselage. The bays accommodate removable slide trays which have various equipment (for example, communications, intelligence, surveillance, and reconnaissance equipment) mounted thereon. The bays and slide trays combination allow for quick removal, insertion, and connection of the various mounted equipment to IP-based connectivity, power, and foundation signals from the aircraft. In an embodiment, the left-side bays, right-side bays, and central compartment each have a planar bottom surface which are substantially equiplanar so that inserted and connected mounted equipment extending downward and externally from the bays from the planar bottom surface have 360 degree unobstructed views.

Fuel injector calibration method and apparatus

A method for matching the performance of a plurality of electronic fuel injectors, includes: applying a supply voltage to a control module; applying an operating voltage signal having a pulse width to each of the plurality of electronic fuel injectors individually via the control module; measuring an amount of time that each of the plurality of electronic fuel injectors supplies fuel; individually adjusting an operating voltage supplied to each of the plurality of electronic fuel injectors to cause each of the electronic fuel injectors to deliver fuel for a substantially same amount of time.

Force Platform System

A method of processing force signals from plural force platforms includes, in a computer, in an initialization process, receiving data distinguishing the plural platforms, monitoring force data signals from each of the plural platforms, and identifying each of the plural platforms to a force platform data process application by a sequence of received above-threshold force data signals. The method further includes, subsequent to the initialization process, processing subsequent force data signals according to the identification of each of the plural force platforms. The distinguishing data can include data retrieved from nonvolatile memory of each of the plural force platforms, such as a platform serial number, calibration data, and force platform capacity. A force platform system includes one or more force platforms and force platform signal conditioning circuitry connected to the one or more force platforms. The signal conditioning circuitry may include a separate signal conditioner connected to each force platform.

Chirurgisches Bewegungsbahnüberwachungssystem und verwandte Verfahren

Verfahren zum Bestimmen der Bewegungsbahn eines chirurgischen Instruments (14) zur Verwendung in Rückgratoperationen, umfassend die Schritte von:a. Koppeln eines ersten Orientierungssensors an eine intraoperative Bildgebungsvorrichtung, wobei der erste Orientierungssensor funktionsfähig ist, um ein erstes Winkelverhältnis in einer ersten Ebene zwischen dem ersten Orientierungssensor und einer Referenzrichtung zu bestimmen, und funktionsfähig ist, um ein zweites Winkelverhältnis in einer zweiten Ebene zwischen dem ersten Orientierungssensor und der Referenzrichtung zu bestimmen, wobei die zweite Ebene orthogonal zur ersten Ebene ist und der erste Orientierungssensor mit der intraoperativen Bildgebungsvorrichtung in einer bekannten Orientierung gekoppelt ist, wobei der erste Orientierungssensor kommunikativ mit einer Steuerungseinheit (16) verbunden ist;b. Erfassen eines Bildes eines vertebralen Pedikels mit der intraoperativen Bildgebungsvorrichtung orientiert in einer ersten Position;c. Verwenden der Steuerungseinheit (16), um einen Wert zu messen, der eine Winkelorientierung des vertebralen Partikels repräsentiert;d. Koppeln eines zweiten Orientierungssensors (12) an ein chirurgisches Instrument (14), wobei der zweite Orientierungssensor (12) funktionsfähig ist, um ein drittes Winkelverhältnis in der ersten Ebene zwischen dem zweiten Orientierungssensor (12) und der Referenzrichtung zu bestimmen und funktionsfähig ist, um ein viertes Winkelverhältnis in der zweiten Ebene zwischen dem zweiten Orientierungssensor (12) und der Referenzrichtung zu bestimmen, wobei der zweite Orientierungssensor (12) mit dem chirurgischen Instrument (14) in einer bekannten Orientierung gekoppelt ist, wobei der zweite Orientierungssensor (12) kommunikativ mit der Steuerungseinheit (16) verbunden ist;e. Justieren der Orientierung des chirurgischen Instrumentes (14), bis der zweite Orientierungssensor (12) anzeigt, dass das chirurgische Instrument (14) mit dem gemessenen Wert, der die ...

Switched diverter circuits for minimizing heating of an implanted lead in a high power electromagnetic field environment

An energy management system that facilitates the transfer of high frequency energy induced on an implanted lead or a leadwire includes an energy dissipating surface associated with the implanted lead or the leadwire, a diversion or diverter circuit associated with the energy dissipating surface, and at least one switch for diverting energy in the implanted lead or the leadwire through the diversion circuit to the energy dissipating surface. In alternate configurations, the switch may be disposed between the implanted lead or the leadwire and the diversion circuit, or disposed so that it electrically opens the implanted lead or the leadwire when diverting energy through the diversion circuit to the energy dissipating surface. The switch may comprise a single or multi-pole double or single throw switch. The diversion circuit may be either a high pass filter or a low pass filter.

Method and apparatus for operating a downhole tool

In another embodiment, a method of drilling a wellbore includes running a drilling assembly into the wellbore through a casing string, the drilling assembly comprising a tubular string, an underreamer, and a drill bit; injecting drilling fluid through the tubular string and rotating the drill bit, wherein the underreamer remains locked in the retracted position; sending an instruction signal to the underreamer via modulation of a rotational speed of the drilling assembly or modulation of a drilling fluid pressure, thereby extending the underreamers; and reaming the wellbore using the extended underreamer.

Method and apparatus for operating a downhole tool

In another embodiment, a method of drilling a wellbore includes running a drilling assembly into the wellbore through a casing string, the drilling assembly comprising a tubular string, an underreamer, and a drill bit; injecting drilling fluid through the tubular string and rotating the drill bit, wherein the underreamer remains locked in the retracted position; sending an instruction signal to the underreamer via modulation of a rotational speed of the drilling assembly or modulation of a drilling fluid pressure, thereby extending the underreamers; and reaming the wellbore using the extended underreamer.

Deep water drilling with casing

Methods and apparatus are provided to place a conductor pipe and a casing in a subsea environment. In one embodiment, a conductor pipe is jetted or drilled into the subsea floor. Thereafter, a casing drilling assembly comprising a drill casing and a drilling assembly is connected to the drill pipe using a crossover. The drilling assembly urged into the seafloor until a casing latch on the drilling assembly is engaged with a casing profile of the conductor pipe. During drilling, instrumentation in the drilling assembly may be used to measure geophysical data. The measured data may be used to optimize the drilling process. After the drill casing is engaged with the conductor pipe, cementing may be performed to set the drill casing.

Deep water drilling with casing

Methods and apparatus are provided to place a conductor pipe and a casing in a subsea environment. In one embodiment, a conductor pipe is jetted or drilled into the subsea floor. Thereafter, a casing drilling assembly comprising a drill casing and a drilling assembly is connected to the drill pipe using a crossover. The drilling assembly urged into the seafloor until a casing latch on the drilling assembly is engaged with a casing profile of the conductor pipe. During drilling, instrumentation in the drilling assembly may be used to measure geophysical data. The measured data may be used to optimize the drilling process. After the drill casing is engaged with the conductor pipe, cementing may be performed to set the drill casing.

Composition of rubberlike qualities

Polyurethane dispersions and methods of making and using same

The presently disclosed and claimed inventive concept(s) relates generally to polyethylene terephthalate ("PET") polymers, digested oligomeric derivatives of PET ("dPET"), functionalized oligomeric derivatives of dPET ("dfPET"), and polyurethane dispersions ("PUD") made from or incorporating dfPET therein.

Paramagnetic complexes of N-alkyl-N-hydroxylamides of organic acids and emulsions containing same for magnetic resonance imaging (MRI)

Emulsions of paramagnetic contrast agents, and processes of making and using them are disclosed. The emulsions contain water, a dispersed oil phase and a complex of a paramagnetic metal ion and an organic acid chelator, for example DTPA (diethylenetriaminepentaacetic acid), having a C 10 -C 30 saturated aliphatic group and an hydroxyl group bonded to the nitrogen atom. The emulsions are very stable and therapeutically acceptable for intravenous administration to enhance MRI imaging.

Benzimidazole analogues for the treatment or prevention of flavivirus infections.

Los compuestos representados por la fórmula (I): (ver fórmula (I)) o sales y solvatos farmacéuticamente aceptables de los mismos, en donde A, B, B', X, Y, R1, R1', R2, R2', R3, R3', R5, R5´, R6, m, n o p son como se define en la presente, son útiles para el tratamiento de infecciones virales por flaviviridae.

Procedure for long term corneal culture

A method for long-term multi-species cornea culture and preservation is provided. Excised mammalian corneas are preserved with structural integrity by filling the endothelial cavity with a plug material. Plugged corneas are sterile-cultured for more than 21 days via an air-interface culture where nutrients from a culture media are supplied to corneal tissue primarily through the plug. Plugged corneas are incubated in culture dishes with a customized media continuously in contact with the ocular sclera and corneal plug, and periodically bathing the corneal surface epithelia. An animal-alternative toxicology assay is also provided using excised porcine corneas capable of assessing ocular injury reversibility within 21 days. Further provided is a method of mammalian corneal preservation for excised human corneas extending their storage life to three to four weeks.

Methods for making non-continuous absorbent cores comprising a porous macrostructure of absorbent gelling particles

A non-continuous absorbent core having a plurality of interconnected strands separated by voids. The strands comprise a porous absorbent macrostructure. The porous macrostructure has interconnected absorbent gelling particles that are surface crosslinked with cationic, preferably polymeric, amino-epichlorohydrin adducts. Upon contacting liquids such as water or body exudates (e.g., urine), the absorbent core can absorb the liquids without undesirable planer expansion. The core is useful in absorbent articles such as diapers, adult incontinence pads, and sanitary napkins are disclosed.

Pierce nut fastening means and method

A pierce nut having a noncylindrical shank is driven through a sheet metal mounting plate into a die so as to excise a slug; further advancement of the nut into the die forces the shank of the nut through a sleeve of the die, to displace metal from the corners of the nut and compact the displaced metal against the mounting plate for securing the nut thereon. Removal of the slug is facilitated by reducing its breadth dimensions within the die cavity, and expelling it with compressed air or by other suitable means.

Method of and apparatus for securing fastener means

Multi-colored cosmetic preparation

Magnetic resonance imaging guidewire probe

The invention describes a system, method, and means for an MRI guidewire that can be visible on an MRI, can act as an antenna and receive MRI signals from surrounding subject matter, and can allow the use of multiple interventional tools without removal of the guidewire from a subject.

Frequency selective passive component networks for active implantable medical devices utilizing an energy dissipating surface

Decoupling circuits are provided which transfer energy induced from an MRI pulsed RF field to the housing for an active implantable medical device (AIMD) which serves as an energy dissipating surface. This is accomplished through broadband filtering or by resonant filtering. In a passive component network for an AIMD, a frequency selective energy diversion circuit is provided for diverting high-frequency energy away from an AIMD lead to the AIMD housing for dissipation of said high-frequency energy.

Switched diverter circuits for minimizing heating of an implanted lead and/or providing EMI protection in a high power electromagnetic field environment

An energy management system that facilitates the transfer of high frequency energy induced on an implanted lead or a leadwire includes an energy dissipating surface associated with the implanted lead or the leadwire, a diversion or diverter circuit associated with the energy dissipating surface, and at least one non-linear circuit element switch for diverting energy in the implanted lead or the leadwire through the diversion circuit to the energy dissipating surface. In alternate configurations, the switch may be disposed between the implanted lead or the leadwire and the diversion circuit, or disposed so that it electrically opens the implanted lead or the leadwire when diverting energy through the diversion circuit to the energy dissipating surface. The non-linear circuit element switch is typically a PIN diode. The diversion circuit may be either a high pass filter or a low pass filter.

Switched diverter circuits for minimizing heating of an implanted lead and/or providing EMI protection in a high power electromagnetic field environment

An energy management system that facilitates the transfer of high frequency energy induced on an implanted lead or a leadwire includes an energy dissipating surface associated with the implanted lead or the leadwire, a diversion or diverter circuit associated with the energy dissipating surface, and at least one switch for diverting energy in the implanted lead or the leadwire through the diversion circuit to the energy dissipating surface. In alternate configurations, the switch may be disposed between the implanted lead or the leadwire and the diversion circuit, or disposed so that it electrically opens the implanted lead or the leadwire when diverting energy through the diversion circuit to the energy dissipating surface. The switch may comprise a single or multi-pole double or single throw switch. The diversion circuit may be either a high pass filter or a low pass filter.

Electromagnetic shield for a passive electronic component in an active medical device implantable lead

A shielded component or network for an active medical device (AMD) implantable lead includes (1) an implantable lead having a length extending from a proximal end to a distal end, all external of an AMD housing, (2) a passive component or network disposed somewhere along the length of the implantable lead, the passive component or network including at least one inductive component having a first inductive value, and (3) an electromagnetic shield substantially surrounding the inductive component or the passive network. The first inductive value of the inductive component is adjusted to a account for a shift in its inductance to a second inductive value when shielded.

Tuned energy balanced system for minimizing heating and/or to provide EMI protection of implanted leads in a high power electromagnetic field environment

An energy management system facilitates the transfer of high frequency energy coupled into an implanted lead at a selected RF frequency or frequency band, to an energy dissipating surface. This is accomplished by conductively coupling the implanted lead to the energy dissipating surface through an energy diversion circuit including one or more passive electronic network components whose impedance characteristics are at least partially tuned to the implanted lead's impedance characteristics.

Implantable lead bandstop filter employing an inductive coil with parasitic capacitance to enhance MRI compatibility of active medical devices

A medical lead system includes at least one bandstop filter for attenuating current flow through the lead across a range of frequencies. The bandstop filter has an overall circuit Q wherein the resultant 3 dB bandwidth is at least 10 kHz. The values of capacitance and inductance of the bandstop filter are selected such that the bandstop filter is resonant at a selected center frequency or range of frequencies. Preferably, the bandstop filter has an overall circuit Q wherein the resultant 10 dB bandwidth is at least 10 kHz. Such bandstop filters are backwards compatible with known implantable deployment systems and extraction systems.

Electromagnetic shield for a passive electronic component in an active medical device implantable lead

A shielded component or network for an active medical device (AMD) implantable lead includes an implantable lead having a length extending from a proximal end to a distal end, all external of an AMD housing, a passive component or network disposed somewhere along the length of the implantable lead, the passive component or network including at least one inductive component having a first inductive value, and an electromagnetic shield substantially surrounding the inductive component or the passive network. The first inductive value of the inductive component is adjusted to account for a shift in its inductance to a second inductive value when shielded.

Cysteine protease inhibitors

The present invention relates to cysteine protease inhibitors of the general formula (I): wherein Z is a cysteine protease binding moiety; X and Y are S, O or optionally substituted N; and R1 is optionally substituted alkyl or aryl.

Two stage entrained gasification system and process

The present invention relates to a system and process for gasifying feedstock such as carbonaceous materials. The invention includes partial combustion of dry solids and pyrolysis of carbonaceous material slurry in two separate reactor sections and produce mixture products comprising synthesis gas. The invention employs one or more catalytic or sorbent bed for removing tar from the synthesis gas. The inventive system and process allow a gasification to be carried out under higher slurry feeding rate and lower temperature with the provision to manage the tar being produced, therefore to increase the conversion efficiency of the overall gasification.

Gasification system and process with staged slurry addition

USEFUL DIAMINOTRIAZOLS AS INHIBITORS OF PROTEINQUINASES

La presente se refiere a diaminotriazoles útiles como inhibidores de proteinazas. También provee composiciones farmacéuticas que comprenden compuestos y métodos para usar dichas composiciones en el tratamiento de varios desórdenes. Reivindicación 1: Un compuesto de fórmula (1) o un sal farmacéutica aceptable de la misma, en la cual R1 es H o Y-R1, donde Y es una cadena de alquilideno opcionalmente sustituida C1-6 en la cual hasta dos unidades metileno están opcionalmente e independientemente reemplazada por -O-, -S-, -NR-, -OCO-, -COO-, o -CO-; cada ocurrencia de R es independientemente H o un grupo alifático C1-6 opcionalmente sustituido; y cada ocurrencia de R´ es independientemente H o un grupo opcionalmente sustituido seleccionado entre un grupo alifático C1-6, un anillo monocíclico de 3-8 miembros, saturado parcialmente insaturado o plenamente insaturado que tiene 0.3 heteroátomos independientemente seleccionados entre N, O, o S, o un anillo bicíclico de 8-12 miembros saturado, parcialmente insaturado plenamente insaturado que tiene 0-5 heteroátomos independientemente seleccionados entre N, O, o S; o R y R¨, son tomadas conjuntamente con el (los) átomo (s) a los cuales están ligada para formar un anillo monocíclico o bicíclico de 3-12 miembros opcionalmente sustituido, saturado, parcialmente insaturado o totalmente insaturado que tiene 0-4 heteroátomos seleccionados independientemente entre N, O, o S; R2 es -(T)nAr1, o -(T)uCy1, donde T es opcionalmente una cadena de alquilideno C14 opcionalmente sustituida donde una unidad metileno de T está opcionalmente reemplazada por -NR-, -S-, -O-, -CS-, -CO2, -OCO-, -CO-, -COCO-, -CONR-, -NRCO, -NRCO2-, SO2NR-, -NRSO2-, -CONRNR-, -NRCONR-, -OCONR-, -NRNR-, -NRSO2NR-, -SO-, -SO2-, -PO-, -PO2-, o -POR-; n es 0 o 1; Ar1 es un grupo arilo opcionalmente sustituido, seleccionado entre un anillo monocíclico de 5-6 miembros o un anillo bicíclico de 8-12 miembros que tienen 0-5 heteroátomos seleccionados independientemente ...

Methods and apparatus for wellbore construction and completion

The present invention relates methods and apparatus for lining a wellbore. In one aspect, a drilling assembly having an earth removal member and a wellbore lining conduit is manipulated to advance into the earth. The drilling assembly includes a first fluid flow path and a second fluid flow path. Fluid is flowed through the first fluid flow path, and at least a portion of which may return through the second fluid flow path. In one embodiment, the drilling assembly is provided with a third fluid flow path. After drilling has been completed, wellbore lining conduit may be cemented in the wellbore.

Apparatus and methods of setting and retrieving casing with drilling latch and bottom hole assembly

In one embodiment, a top drive system for drilling with casing is provided with an access tool to retrieve a downhole tool. The top drive system for drilling with casing comprises a top drive; a top drive adapter for gripping the casing, the top drive adapter operatively coupled to the top drive; and an access tool coupled to the top drive and adapted for accessing a fluid passage of the top drive system. In another embodiment, a method for retrieving a downhole tool through a tubular coupled to a top drive adapter of a top drive system is provided. The method comprises coupling an access tool to the top drive system, the access tool adapted to provide access to a fluid path in the top drive system and inserting a conveying member into the fluid path through the access tool.

Methods and apparatus for drilling with casing

In one embodiment, a method of forming a wellbore includes running a liner drilling assembly into the wellbore, the liner drilling assembly having a liner, a conveying member, one or more connection members, and a drilling member. The method includes temporarily suspending the liner at a location below the rig floor; releasing the conveying member and the drilling member from the liner; re-connecting the conveying member to the liner; releasing the liner from its location of temporary suspension; and advancing the liner drilling assembly.

Apparatus for gripping a tubular on a drilling rig

Methods and apparatus for running tubulars into and out of a wellbore. A gripping apparatus is activated with an actuator having a primary actuator and a redundant safety feature. The redundant safety feature may include one or more redundant fluid operated pistons. The gripping apparatus may include an integrated safety system adapted to prevent damage to the tubulars while making and breaking out connections between the tubulars and the tubular string.

Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors

The present invention relates to certain substituted oxadiazole nonpeptides, which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respiratory distress syndrome, septic shock and multiple organ failure. A series of studies also have indicated the involvement HNE in myocardial ischemia-reperfusion injury, emphysema. HNE-mediated processes are implicated in other conditions such as arthritis, periodontal disease, glomerulonephritis, dermatitis, psoriasis, cystic fibrosis, chronic bronchitis, atherosclerosis, Alzheimer's disease, organ transplantation, corneal ulcers, and invasion behavior of malignant tumors.

Contaminant removal from a gas stream

A system employing a regenerable zinc-oxide based sorbent to remove one or more contaminants from an incoming gas stream. The contaminant-depleted gas stream can then be used for any subsequent application, while at least a portion of the contaminant-laden sorbent can be regenerated via a step-wise regeneration process. In one embodiment, sorbent regenerated via the step-wise regeneration process can comprise less sorbent-damaging compounds than traditional sorbents exposed to conventional regeneration processes.

Articulation joint

An endoscopic imaging system includes a reusable control cabinet having a number of actuators that control the orientation of a lightweight endoscope that is connectable thereto. The endoscope is used with a single patient and is then disposed. The endoscope includes an illumination mechanism, an image sensor and an elongate shaft having one or more lumens located therein. A polymeric articulation joint at the distal end of the endoscope allows the distal end to be oriented by the control cabinet. The endoscope is coated with a hydrophilic coating that reduces its coefficient of friction and because it is lightweight, requires less force to advance it to a desired location within a patient.

Endoscopic imaging system

An endoscopic imaging system includes a reusable control cabinet having a number of actuators that control the orientation of a lightweight endoscope that is connectable thereto. The endoscope is used with a single patient and is then disposed. The endoscope includes an illumination mechanism, an image sensor and an elongate shaft having one or more lumens located therein. A polymeric articulation joint at the distal end of the endoscope allows the distal end to be oriented by the control cabinet. The endoscope is coated with a hydrophilic coating that reduces its coefficient of friction and because it is lightweight, requires less force to advance it to a desired location within a patient.

Endoscopic imaging system

An endoscopic imaging system includes a reusable control cabinet having a number of actuators that control the orientation of a lightweight endoscope that is connectable thereto. The endoscope is used with a single patient and is then disposed. The endoscope includes an illumination mechanism, an image sensor and an elongate shaft having one or more lumens located therein. A polymeric articulation joint at the distal end of the endoscope allows the distal end to be oriented by the control cabinet. The endoscope is coated with a hydrophilic coating that reduces its coefficient of friction and because it is lightweight, requires less force to advance it to a desired location within a patient.

Endoscopic imaging system

An endoscopic imaging system includes a reusable control cabinet having a number of actuators that control the orientation of a lightweight endoscope that is connectable thereto. The endoscope is used with a single patient and is then disposed. The endoscope includes an illumination mechanism, an image sensor and an elongate shaft having one or more lumens located therein. A polymeric articulation joint at the distal end of the endoscope allows the distal end to be oriented by the control cabinet. The endoscope is coated with a hydrophilic coating that reduces its coefficient of friction and because it is lightweight, requires less force to advance it to a desired location within a patient.

Non-continuous absorbent composites comprising a porous macrostructure of absorbent gelling particles and a substrate

A non-continuous absorbent composite having a plurality of interconnected strands separated by voids. The strands comprises a porous, absorbent macrostructure and a substrate. The porous macrostructure has interconnected absorbent gelling particles that are surface crosslinked with cationic, preferably polymeric, amino-epichlorohydrin adducts. Upon contacting liquids such as water or body exudates (e.g., urine), the absorbent composite can absorb the liquids without undesirable planer expansion, The composite is useful in absorbent articles such as diapers, adult incontinence pads, and sanitary napkins are disclosed.

Non-continuous absorbent cores comprising a porous macrostructure of absorbent gelling particles

A non-continuous absorbent core having a plurality of interconnected strands separated by voids. The strands comprises a porous absorbent macrostructure. The porous macrostructure has interconnected absorbent gelling particles that are surface crosslinked with cationic, preferably polymeric, amino-epichlorohydrin adducts. Upon contacting liquids such as water or body exudates (e.g., urine), the absorbent core can absorb the liquids without undesirable planer expansion. The core is useful in absorbent articles such as diapers, adult incontinence pads, and sanitary napkins are disclosed.

Stain-resistant no-mix orthodontic adhesive

A stain resistant no-mix orthodontic adhesive is disclosed. The adhesive comprises: (a) a first component having a relatively low viscosity and which contains an acrylic or methacrylic diester of ethoxylated bisphenol-A, an acrylic or methacrylic diester of an alkanediol, and benzyl acrylate or methacrylate; and (b) a second component containing a filler and an acrylic or methacrylic diester of ethoxylated bisphenol-A, an acrylic or methacrylic diester of an alkanediol, and benzyl methacrylate or acrylate, said filler being present in an amount within the range of from about 50 to about 80 weight percent of said second component, wherein, one of said first and second components contains a perioxide catalyst and the other of said components contains a tertiary amine activator for said peroxide catalyst.

Magnetic resonance imaging guidewire probe

The invention describes a system, method, and means for an MRI guidewire that can be visible on an MRI; can act as an antenna, and receive MRI signals from surrounding subject matter; and can allow the use of multiple interventional tools without removal of the guide wire from a subject. The antenna (106) extends beyond probe shaft (105) at distal end (109). The probe shaft (105) has a core (101), first electric (102), shield (103), and second dielectric (104).

Dimensionally stable balloons

A medical balloon composed of a micro-composite material which provides for radial expansion of a balloon to a predetermined extent, but which has minimal longitudinal growth during balloon inflation. The micro-composite material includes a fibril component, a matrix component,and optionally, a compatibilizer. The fibril component may preferably be liquid crystal polymer fibers randomly scattered through out the balloon material. The liquid crystal polymers are created by extrusion at high speed. An alternative fibril component may be PET fibers which are uniformly spaced about the balloon material and extend through out the length of the balloon material tube.

Steam iron

Methods and apparatus for drilling with casing

In one embodiment, a method of forming a wellbore includes running a liner drilling assembly into the wellbore, the liner drilling assembly having a liner, a conveying member, one or more connection members, and a drilling member. The method includes temporarily suspending the liner at a location below the rig floor; releasing the conveying member and the drilling member from the liner; re-connecting the conveying member to the liner; releasing the liner from its location of temporary suspension; and advancing the liner drilling assembly.

Two stage entrained gasification system and process

The present invention relates to a system and process for gasifying feedstock such as carbonaceous materials. The invention includes partial combustion of dry solids and pyrolysis of carbonaceous material slurry in two separate reactor sections and produce mixture products comprising synthesis gas. The invention employs one or more catalytic or sorbent bed for removing tar from the synthesis gas. The inventive system and process allow a gasification to be carried out under higher slurry feeding rate and lower temperature with the provision to manage the tar being produced, therefore to increase the conversion efficiency of the overall gasification.

Magnetic resonance imaging guidewire probe

The invention describes a system, method, and means for an MRI guidewire that can be visible on an MRI; can act as an antenna, and receive MRI signals from surrounding subject matter; and can allow the use of multiple interventional tools without removal of the guide wire from a subject. The antenna (106) extends beyond probe shaft (105) at distal end (109). The probe shaft (105) has a core (101), first electric (102), shield (103), and second dielectric (104).

DIAMINOTRIAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS

Photopolymer printing plates having a dimpled printing surface

ABSTRACT The present invention provides a photopolymer printing plate for use in flexographic printing wherein the photopolymer relief structure is composed of printing characters of uniform printing height, the planar printing surfaces of which characters contain a plurality of well-like dimples or depressions present at a density within the range of from about 25 to about 500 depressions per linear inch of planar printing surface. The invention also provides a process for preparing such photopolymer plates by exposing the photopolymer layer to actinic radiation through a photographic mask containing optically transparent areas and optically opaque image areas, the transparent areas of said mask characterized by the presence of a plurality of opaque discrete dots or other geometric shapes present at a density of from about 25 to about 500 dots per linear inch. These dots serve to block a portion of the light passing through the transparent areas of the mask thereby forming discrete regions in the underlying photopolymer layer which are not exposed or are only partially exposed. Upon development of the plate, the regions of the photopolymer layer underlying the dot pattern are removed resulting in the formation of a plurality of depressions in the relief planar surface of the exposed portions of the photopolymer layer. Upon the application of printing ink to the relief printing surface of the plates of this invention, the depressions on the relief surface act as ink reservoirs resulting in the application of a more even distribution of ink to surfaces to be printed, particularly where large solid areas are printed.

Imaging toolbox for guiding cardiac resynchronization therapy implantation from patient-specific imaging and body surface potential mapping data

The present invention is directed to a method for combining assessment of different factors of dyssynchrony into a comprehensive, non-invasive toolbox for treating patients with a CRT therapy device. The toolbox provides high spatial resolution, enabling assessment of regional function, as well as enabling derivation of global metrics to improve patient response and selection for CRT therapy. The method allows for quantitative assessment and estimation of mechanical contraction patterns, tissue viability, and venous anatomy from CT scans combined with electrical activation patterns from Body Surface Potential Mapping (BSPM). This multi-modal method is therefore capable of integrating electrical, mechanical, and structural information about cardiac structure and function in order to guide lead placement of CRT therapy devices. The method generates regional electro-mechanical properties overlaid with cardiac venous distribution and scar tissue. The fusion algorithm for combining all of the data suggests cardiac segments and routes for implantation of epicardial pacing leads.

A method of drilling a wellbore

5 A radio-frequency identification device (RFID) for use in a wellbore is disclosed. The device includes a housing made of a polymer; and an antenna disposed in the housing. The polymer may be selected from the group consisting of an elastomer, a plastic, a rubber, a thermoplastic elastomer, and combinations thereof. The RFID device may also include a fill material disposed in the housing. A method of drilling a 10 well bore is also disclosed. The method includes using the RFID to send a first instruction signal to a first underreamer to extend the first underreamer then sending a second instruction signal to a second underreamer to extend the second underreamer. FIG 4 for publication Coc o CD 0v C) (o 194- 04 0c

Adhesive primer for alumina articles

Abstract of the Disclosure The adhesive strength of alumina articles to acrylic adhesive cements is enhanced by forming an essentially silica coating on the bonding surface of the article by the steps of coating said surface with an organosilicon compound such as a silane and then pyrolyzing the organosilicon coating to volatilize the organic components thereof to thereby leave an essentially silica coating.

Gasification system and process with staged slurry addition

A system and process for gasifying carbona-ceous feedstock with staged slurry addition in order to prevent the formation of tar that causes deposition problems. Dry solid carbonaceous material is partially combusted, then pyrolysed along with a first slurry stream comprising carbonaceous ma-terial in two separate reactor sections, thereby producing mix-ture products comprising synthesis gas. The second slurry stream comprising particulate carbonaceous material is fed to a drying unit downstream of a heat recovery zone along with the mixture product exiting the heat recovery zone. The result-ing final temperature of the second stage mixture products and dried particulate carbonaceous material is between 450° and 550°F, a temperature range that is typically not conducive to the emission of heavy molecular-weight tar species.

Thermal printing cartridge

ABSTRACT A printing cartridge adapted for use with thermal transfer printing apparatus. The cartridge includes a frame defining first and second printing stations, a ribbon supply spool, and a ribbon take-up spool, both of the spools being rotatably mounted on the frame. The ribbon has a backing layer and an ink donor layer and is guided in a feed path extending from the supply spool through the first and second printing stations, again through the first station, then to the take-up spool. The frame of the cartridge is adapted to receive a thermal printing head for engaging the ribbon at each of the first and second printing stations. The feed path has a first leg extending from the supply spool, through the first printing station, to the second printing station; a second leg extending through the second printing station to the first printing station; and a third leg extending through the first printing station to the take-up spool. A ribbon backing roller rotatably mounted on the frame engages the ribbon in the third leg of the feed path at the first printing station such that ink from the ribbon in the first leg of the feed path at the first printing station is transferred to the ribbon in the third leg of the feed path also at the first printing station. The thermal printing head at the second printing station engages the ribbon in the second leg of the feed path such that ink is transferred to a workpiece. The ink may be of the fluorescent type.

Two stage entrained gasification system and process

The present invention relates to a system and process for gasifying feedstock such as carbonaceous materials. The invention includes partial combustion of dry solids and pyrolysis of carbonaceous material slurry in two separate reactor sections and produce mixture products comprising synthesis gas. The invention employs one or more catalytic or sorbent bed for removing tar from the synthesis gas. The inventive system and process allow a gasification to be carried out under higher slurry feeding rate and lower temperature with the provision to manage the tar being produced, therefore to increase the conversion efficiency of the overall gasification.

Absorption refrigeration system

Apparatus for gripping a pipe on a drilling rig

Fremgangsmåte og apparat for kjøring av rør inn i og ut av et brønnhull. Et gripeapparat aktiveres med en aktuator som har en primær aktuator og et redundant sikkerhetstrekk. Det redundante sikkerhetstrekk kan innbefatte ett eller flere redundante fluidopererte stempler. Gripeapparatet kan innbefatte integrert sikkerhetssystem som er tilpasset for å hindre skade på rørene mens forbindelser mellom rørene og rørstrengen gjøres opp og frakoples. Method and apparatus for driving pipes into and out of a wellbore. A gripper is activated by an actuator having a primary actuator and a redundant safety feature. The redundant safety feature may include one or more redundant fluid operated pistons. The gripper may include an integrated safety system adapted to prevent damage to the pipes while making connections and disconnecting the pipes.

Apparatus for gripping a tubular on a drilling rig

A method and apparatus for handling tubular on a drilling rig. The apparatus is adapted for gripping a tubular and may be used with a top drive. The apparatus includes a connection at one end for rotationally fixing the apparatus to the top drive and gripping members at a second end for gripping the tubular. The apparatus has a primary actuator configured to move and hold the gripping members in contact with the tubular and a backup assembly to maintain the gripping member in contact with the tubular. WO 2007/070805 PCT/US2006/061945 118 -115 ,-.120

Tuning fork

Roofing material

Method and apparatus for operating a downhole tool

In another embodiment, a method of drilling a wellbore includes running a drilling assembly into the wellbore through a casing string, the drilling assembly comprising a tubular string, an underreamer, and a drill bit; injecting drilling fluid through the tubular string and rotating the drill bit, wherein the underreamer remains locked in the retracted position; sending an instruction signal to the underreamer via modulation of a rotational speed of the drilling assembly or modulation of a drilling fluid pressure, thereby extending the underreamers; and reaming the wellbore using the extended underreamer.

Tachometer for downhole drilling motor

A tachometer for a downhole motor includes: a tubular housing having a coupling for connection to a housing of the motor; and a probe. The probe: has a coupling for connection to a rotor of the motor, is movable relative to the tachometer housing, and has at least a portion disposed in a bore of the tachometer housing. The tachometer further includes electronics disposed in the tachometer housing and including: a battery; one or more proximity sensors for tracking an orbit of the probe; and a programmable logic controller (PLC). The PLC is operable: to receive the tracked orbit, and at least one of: to determine an angular speed of the probe using the tracked orbit, and to forecast a remaining lifespan of the motor using the tracked orbit.

Two-stage gasifier and gasification process with feedstock flexibility

A gasification process may include (a) introducing a liquid hydrocarbon feedstock and at least one of a dry feedstock or a first slurried feedstock into a reactor lower section, wherein the at least one dry feedstock or first slurried feedstock is introduced through two primary feed nozzles while the liquid hydrocarbon feedstock is introduced through at least two secondary feed nozzles; (b) partially combusting the feedstocks in the reactor lower section with a gas stream comprising an oxygen-containing gas or steam to evolve heat and form products comprising hot synthesis gas; (c) passing said hot synthesis gas from step (b) upward into a reactor upper section; (d) and introducing a second slurried feedstock into said reactor upper section, whereby heat from said hot synthesis gas supports reaction of the second slurried feedstock by pyrolysis and gasification reactions.

Controller for downhole tool

A controller for operating a downhole tool includes a tubular body; a seat disposed in the body for receiving first and second pump-down plugs, at least a portion of one of the seat and the plugs being radially displaceable to pass through or allow passage of the other at a first threshold pressure differential; a catcher located below the seat for receiving the plugs after passing through the seat; a toggle linked to the seat to alternate between a locked position and an unlocked position in response to seating of the plugs; and a control mandrel for engaging a piston of the downhole tool and linked to the toggle: to be longitudinally movable between a first position and a second position when the toggle is unlocked, and to be prevented from movement from the first position to the second position when the toggle is locked.

Isoindolinone inhibitors of phosphatidylinositol 3-kinase.

La presente invención se refiere a compuestos útiles como inhibidores de PI3K, particularmente de PI3Ky. La invención también proporciona composiciones farmacéuticamente aceptables que comprenden los compuestos y métodos para usar las composiciones en el tratamiento de diversas enfermedades, afecciones o trastornos.

Methods and apparatus for wellbore construction and completion

The present invention relates methods and apparatus for lining a wellbore. In one aspect, a drilling assembly having an earth removal member and a wellbore lining conduit is manipulated to advance into the earth. The drilling assembly includes a first fluid flow path and a second fluid flow path. Fluid is flowed through the first fluid flow path, and at least a portion of which may return through the second fluid flow path. In one embodiment, the drilling assembly is provided with a third fluid path. After drilling has been completed, wellbore lining conduit may be cemented in the wellbore.

Extendable cutting tools for use in a wellbore

Embodiments of the present invention generally relate to extendable cutting tools for use in a wellbore. In one embodiment, a tool for use in a wellbore includes a tubular body having a bore therethrough, an opening through a wall thereof, and a connector at each longitudinal end thereof; and an arm. The arm is pivotally connected to a first piston and rotationally coupled to the body, is disposed in the opening in a retracted position, and is movable to an extended position where an outer surface of the arm extends outward past an outer surface of the body. The tool further includes the first piston. The first piston is disposed in the body bore, has a bore therethrough, and is operable to move the arm from the retracted position to the extended position in response to fluid pressure in the piston bore exceeding fluid pressure in the opening. The tool further includes a lock operable to retain the first piston in the retracted position; and a second piston operably coupled to the lock.

Methods and systems for treating a gasification slag product

The current invention discloses a novel process and system to improve the quality of the slag product from a gasification process, thereby producing low-carbon marketable aggregate product. The inventive processes and systems employ a hindered-bed settler in conjunction with optional disengager and de-watering devices. A slag slurry stream from a gasification process is de-watered and the solids content is increased from less than 5% to greater than 30% via the de-waterer before being conveyed to a hindered-bed settler, wherein the carbon content is reduced from as much as 70% to less than 5%. Particles with a high carbon content are conveyed to a gravity settler, whereby they are concentrated and then recycled to the gasification reactor.

Subsea drilling with casing

A method of forming a wellbore includes providing a drilling assembly comprising one or more lengths of casing and an axially retracting assembly having a first tubular; a second tubular at least partially disposed in the first tubular and axially fixed thereto; and a support member disposed in the second tubular and movable from a first axial position to a second axial position relative to the second tubular, wherein, in the first axial position, the support member maintains the second tubular axially fixed to the first tubular, and in the second axial position, allows the second tubular to move relative to the first tubular; and an earth removal member disposed below the axially retracting assembly. The method also includes rotating the earth removal member to form the wellbore; moving the support member to the second axial position; and reducing a length of the axially retracting assembly.

Apparatus, systems and methods for in vivo magnetic resonance imaging

The apparatus, systems and methods of the present invention provide for MRI sleeves, probes, and combinations thereof adapted for insertion into a subject, in order to internally image regions of the subject.

Pressure activated release member for an expandable drillbit

An apparatus for use in a wellbore. The apparatus includes a body and a blade assembly. The blade assembly is movable between a collapsed position whereby the expandable apparatus has a smaller outer diameter and an expanded position whereby the expandable apparatus has a larger outer diameter. The apparatus further includes a pressure activated member for selectively allowing the blade assembly to move from the closed position to the open position. A method for using the apparatus, wherein a drill string with an expandable bit at the end thereof is lowered into the wellbore. Thereafter, the pressure activated member is activated to allow the cutting members to move from the collapsed position to the expanded position. Subsequently, the expandable bit is rotated to form a portion of the wellbore. Next, the expandable bit is deactivated and the cutting members are moved from the expanded position to the collapsed position.

Earth removal member with features for facilitating drill-through

An earth removal member for drilling a wellbore with casing or liner includes a tubular body and a head. The head is fastened to or formed with an end of the body, has a face and a side, is made from a high strength material, and has a port formed through the face. The earth removal member further includes a blade. The blade is formed on the head, extends from the side and along the face, and is made from the high strength material. The earth removal member further includes cutters disposed along the blade; and a nozzle adapter. The nozzle adapter has a port formed therethrough, is longitudinally and rotationally coupled to the head, and is made from a drillable material. The earth removal member further includes a nozzle disposed in the adapter port and fastened to the nozzle adapter.

Three dimensional steerable system

A steering assembly (20) includes upper (26) and lower (28) tubular housings connected by a universal joint (30). An angle cam (80) is d is- posed on the end of the lower housing and projects into the housing. A plurality of wedge members (90) extend axially from the upper housing and into engage- ment with the angle cam. Drive trains (150) are connected to the wedge members to move the wedge members toward and away from the angle cam to change the angle and azimuth of the lower housing with respect to the upper housing by the universal joint. The lower housing is connected to a bearing pack (16) s up- porting a drill bit (12) so as to change the direction of the drill bit. The steerin g assembly is connected to composite tubing (520) having conductors (584, 586) in the wall and a processor (514) is at the surface. Data on the position of the bit is transmitted to the processor to change the bend angle and direction o f the drilling of the bit.

Construction material

Methodology and apparatus to terminate abandoned active implantable medical device leads

An energy management system facilitates the transfer of high frequency energy coupled into an implanted abandoned lead at a selected RF frequency or frequency band, to an energy dissipating surface. This is accomplished by conductively coupling the implanted abandoned lead to the energy dissipating surface of an abandoned lead cap through an energy diversion circuit including one or more passive electronic network components whose impedance characteristics are at least partially tuned to the implanted abandoned lead's impedance characteristics.

Disposable endoscope imaging system

【課題】内視鏡には、良い進路誘導、追跡性、操作者との優れたインターフェース、内腔組織に対する摩擦力低下によるアクセス向上、患者の快適度の増加、などが求められている。 【解決手段】内視鏡画像システムは、制御キャビネットに接続可能な軽量内視鏡の方向付けを制御するいくつかのアクチュエータを有する再利用可能な制御キャビネットを含む。この内視鏡は一人の患者に対して使用、配置される。この内視鏡は照明機構、イメージセンサー、および内部に設置された一つ以上の穴を有する長形軸を含む。内視鏡の遠位端の関節ジョイントにより、遠位端が制御キャビネット内のアクチュエータにより方向付けられる。内視鏡は摩擦係数を減少させる親水性コーティングで被覆され、軽量なため、患者内部の所望位置に内視鏡を前進させる力がより少ない。 【選択図】図３Ｃ

Bit connector

The drilling assembly includes an eccentric adjustable diameter blade stabilizer (30), having a housing (43) with a fixed stabilizer blade (32) an d a pair of adjustable stabilizer blades (34, 36), and a bi-center bit (20), having an eccentric reamer section (24) and a pilot bit (22), mounted on the eccentric stabilizer (30). The stabilizer (30) and bit (20) have an alignmen t mechanism (40) for aligning the fixed blade (32) with the reamer section (24 ). The alignment mechanism (40) includes an aperture (44) on the bit (20) which is aligned with an aperture (42) on the stabilizer (30) as the stabilizer (3 0) is made up on the bit (20). An alignment member (48) is received by the aligned apertures (42, 44) for maintaining the alignment.

Low temperature sulfur tolerant tar and sulfur removal with contomitant synthesis gas conditioning

A catalyst comprising of NiO; Al 2 O 3 ; and ZnO. The catalyst is capable of greater than 5% sulfur removal from a synthesis gas at a temperature range from 300°C to 600°C.

Apparatus for gripping a tubular on a drilling rig

Methods and apparatus for running tubulars into and out of a wellbore. A gripping apparatus is activated with an actuator having a primary actuator and a redundant safety feature. The redundant safety feature may include one or more redundant fluid operated pistons. The gripping apparatus may include an integrated safety system adapted to prevent damage to the tubulars while making and breaking out connections between the tubulars and the tubular string.

Pyrrolopyrimidine useful as inhibitor of protein kinase

【課題】プロテインキナーゼ、例えばＪＡＫファミリー、ＲＯＣＫ及びＰＫＡキナーゼの阻害剤として有用な化合物を開発すること。 【解決手段】本発明のピロロピリミジン化合物またはその薬学的に受容可能な塩及びその薬学的に受容可能な組成物は、プロテインキナーゼ、例えばＪＡＫファミリー、ＲＯＣＫ及びＰＫＡキナーゼの阻害剤として有効である。特定の実施形態においては、これらの化合物はＪＡＫ３プロテインキナーゼの阻害剤として有効である。 【選択図】なし

Portable table with pivotally mounted frame

Method and apparatus for creating soil or rock subsurface support

A subsurface support is provided in the form of a soil nail. The soil nail has asperities formed on the outer surface thereof to improve the pullout capacity of the soil nail. The asperities can take a number of forms to include indentations, deformations and threads formed on the outer surface of the soil nail. Optionally, a stinger may be attached to a distal end of the soil nail to further enhance the pullout capacity of the soil nail.

Liquid seal for absorption systems

Endoluminal mri probe

LIQUID PRESSURE REINFORCEMENT DEVICE

Apparatus for gripping a tubular on a drilling rig

Two stage entrained gasification system and process

The present invention relates to a system and process for gasifying feedstock such as carbonaceous materials. The invention includes partial combustion of dry solids and pyrolysis of carbonaceous material slurry in two separate reactor sections and produce mixture products comprising synthesis gas. The invention employs one or more catalytic or sorbent bed for removing tar from the synthesis gas. The inventive system and process allow a gasification to be carried out under higher slurry feeding rate and lower temperature with the provision to manage the tar being produced, therefore to increase the conversion efficiency of the overall gasification.

Tachometer for downhole drilling motor

A tachometer for a downhole motor includes: a tubular housing having a coupling for connection to a housing of the motor; and a probe. The probe: has a coupling for connection to a rotor of the motor, is movable relative to the tachometer housing, and has at least a portion disposed in a bore of the tachometer housing. The tachometer further includes electronics disposed in the tachometer housing and including: a battery; one or more proximity sensors for tracking an orbit of the probe; and a programmable logic controller (PLC). The PLC is operable: to receive the tracked orbit, and at least one of: to determine an angular speed of the probe using the tracked orbit, and to forecast a remaining lifespan of the motor using the tracked orbit.

Val-pro containing α-keto oxadiazoles as serine protease inhibitors

The present invention relates to certain substituted oxadiazole tripeptides, which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respiratory distress syndrome, septic shock and multiple organ failure. A series of studies also have indicated the involvement HNE in myocardial ischemia-reperfusion injury, emphysema. HNE-mediated processes are implicated in other conditions such as arthritis, periodontal disease, glomerulonephritis, dermatitis, psoriasis, cystic fibrosis, chronic bronchitis, atherosclerosis, Alzheimer's disease, organ transplantation, corneal ulcers, and invasion behavior of malignant tumors.