Optical rotary joints, methods of mounting same in a properly-aligned manner, and optical reflector assemblies for use therein

The present invention relates generally to optical rotary joints () for enabling optical communication between a rotor and a stator, and to improved methods of mounting such optical rotary joints on supporting structures such that the rotor and stator remain properly aligned. 152-. (canceled)53. The method of mounting an optical rotary joint on a supporting frame , comprising the steps of:{'b': 60', '61', '62', '63', '64, '(a) providing a tooling plate () having an annular inner portion () provided with a plurality of circularly-spaced radially-extending V-grooves (), and having an arcuate outer portion () provided with a plurality of circularly-spaced pockets (), each pocket being adapted to receive a reflector assembly in a predetermined position relative to the proximate V-grooves;'}{'b': '50', '(b) providing a plurality of optical reflector assemblies ();'}(c) placing an optical reflector assembly in each pocket;(d) providing a plurality of assembled optical collimators, each assembled optical collimator having a fiber and a collimator assembly;(e) placing said plurality of assembled optical collimators in said tooling plate V-grooves;(f) testing the integrity of the optical connection between said fiber and collimator assembly and the proximate optical reflector assembly;(g) providing a stator segment;(h) placing said stator segment on said optical reflector assemblies;(i) mounting the optical reflector assemblies to the stator segment to form an assembled stator;(j) removing the said assembled stator from the tooling plate;{'b': '65', '(k) placing cylindrical gauge pins () in at least some of said V-grooves;'}{'b': '66', '(l) providing a plurality of rotor segments (), each rotor segment having a plurality of circularly-spaced radially-extending V-grooves;'}(m) placing said rotor segments such that said gauge pins are received in said rotor segment V-grooves;{'b': '68', '(n) joining said rotor segments to form an assembled rotor ();'}(o) removing said ...

Optical rotary joints, methods of mounting same in a properly-aligned manner, and optical reflector assemblies for use therein

The present invention relates generally to optical rotary joints () for enabling optical communication between a rotor and a stator, and to improved optical reflector assemblies for use in such optical rotary joints. 137-. (canceled)3850. An optical reflector assembly () for enabling optical communication between a rotor and a stator , said rotor having a longitudinal axis , comprising:{'b': 51', '52, 'sub': 1', '2', '1, 'a first member () having a concave first reflective surface (), a line (L) in a plane taken through said first reflective surface being configured as a portion of an ellipse having first and second focal points (F, F), said first focal point (F) being positioned substantially coincident with said rotor axis;'}{'b': 53', '51, 'a second member () mounted on one side of said first member ();'}{'b': 56', '51, 'a third member () mounted on the opposite side of said first member ();'}{'b': 54', '53', '55, 'a fourth member () mounted on said second member () and having a second reflective surface () having a longitudinal axis;'}{'b': 58', '56', '52', '55, 'sub': '1', 'receiving optics () mounted on said third member () such that an optical signal seen as originating from said first focal point (F), falling incident on said first reflective surface (), and being further reflected toward said second reflective surface () will be further reflected toward said receiving optics; and receiver'}{'b': '59', 'an optical fiber () having an entrance end and an exit end, said entrance end being arranged adjacent to said receiving optics; and'}{'b': 52', '55', '52', '52', '55', '55', '52, 'sub': 2', '2', '2, 'wherein said first reflective surface () is configured as a portion of an ellipsoid and said second reflective surface () is configured as a portion of a cone positioned at the second focal point (F) of said first reflective surface () such that an optical signal reflected by said first reflective surface () toward said second focal point (F) converges to a spot ...

Safety System with Window Breaker for a Vehicle, Vehicle Provided Therewith and Method Therefor

The invention relates to a safety system for a vehicle, a vehicle provided therewith and a method for breaking a window. The safety system comprises: a window breaker comprising: a drive system; and a pin driven by the drive system for breaking a window; activating means operatively connected to the drive system for control thereof, wherein the activating means comprise a water sensor for controlling the drive system therewith. 1. Safety system for a vehicle , comprising: a drive system; and', 'a pin driven by the drive system for breaking a window; and, 'a window breaker comprisingactivating means operatively connected to the drive system for control thereof, wherein the activating means comprise a water sensor for controlling the drive system therewith.2. Safety system as claimed in claim 1 , wherein the water sensor is accommodated in a separate housing.3. Safety system as claimed in claim 1 , wherein the water sensor is accommodated in a housing which is provided with openings such that claim 1 , if the housing is situated in water claim 1 , it is filled within a determined period of time.4. Safety system as claimed in claim 1 , wherein the water sensor is embodied such that it activates the drive system if the sensor is substantially wholly enveloped by water.5. Safety system as claimed in claim 4 , wherein the water sensor comprises at least two detection elements.6. Safety system as claimed in claim 1 , comprising a capacitor for energy supply.7. Safety system as claimed in claim 1 , wherein the activating means control the drive system with a predetermined time delay.8. Safety system as claimed in claim 1 , comprising signalling means controlled by the activating means for the purpose of generating a warning signal.9. Safety system as claimed in claim 1 , further comprising an operating means for manual switch-on and switch-off of the activating means.10. Safety system as claimed in claim 1 , wherein the drive system comprises an explosive charge.11. Safety ...

Interconnect structure and method for producing same

There is provided a three-dimensional interconnect structure for micro-electronic devices and a method for producing such an interconnect structure. The method comprises a step wherein a backbone structure is manufactured using an additive layer-wise manufacturing process. The backbone structure comprises a three-dimensional cladding skeleton and a support structure. The cladding skeleton comprises layered freeform skeleton parts that will form the electric interconnections between the electric contacts of the interconnect structure after a conductive material is applied on the backbone structure. The support structure supports the layered freeform skeleton parts. Parts of the support structure may be removed to isolate and/or expose the electric interconnections. The cladding skeleton can be embedded by an insulating material for providing a further support.

ACTIVE CARRIER FOR CARRYING A WAFER AND METHOD FOR RELEASE

In the field of release and pickup of ultrathin semiconductor dies, there is provided an active carrier () for carrying a wafer () and a method for using such a carrier (). The wafer () comprises a particular die arrangement (P). The active carrier () comprises a base plate () and a number of energizers () constructed on or in this base plate (). The energizers () are laid out in an arrangement corresponding to the die arrangement (P). The energizers () can locally energize an adhesive layer () in proximity to a selected die () from the die arrangement (P). By this local energizing of the adhesive layer (P), the selected die is loosened from the adhesive layer (). Furthermore the active carrier () comprises a plurality of externally addressable contacts () and conduction pathways (). The conduction pathways () connect the contacts () to the energizers () thereby allowing individual control over said energizers () by addressing said contacts (). 1. An active carrier dedicated to carry a wafer comprising a die arrangement , which active carrier comprisesa base plate;a plurality of energizers constructed on or in said base plate and laid out in an arrangement corresponding to the die arrangement configured for locally energizing of an adhesive layer in proximity to a selected die from said die arrangement, thereby by said configuration, making able to loosen said selected die from the adhesive layer;a plurality of externally addressable contacts; andconduction pathways connecting said contacts to said energizers thereby configured to allow individual control over said energizers by addressing said contacts.2. An active carrier according to claim 1 , wherein said energizer comprises a resistor.3. An active carrier according to claim 1 , wherein said energizer comprises a LED.4. An active carrier according to claim 1 , wherein said energizer comprises a VCSEL.5. An active carrier according to claim 1 , further comprising the adhesive layer.6. An active carrier according ...

Storage Device for Fresh Products, and Tablet and Method Therefor

The present invention relates to a storage device for fresh products and/or perishable produce and a method for storing fresh products, comprising: a cabinet provided with an access door and/or flap; one or more substantially gastight compartments arranged in the cabinet and provided with at least one gas inlet and one gas outlet; and conditioning means suitable for conditioning the climate in the compartment, wherein the conditioning comprises of providing desired gas conditions, including oxygen content. 1. A storage device for fresh products and/or perishable produce , comprising:a cabinet provided with an access door and/or flap;one or more substantially gastight compartments arranged in the cabinet and provided with at least one gas inlet and one gas outlet; andconditioning means suitable for conditioning the climate in the compartment, wherein the conditioning comprises of providing desired gas conditions, including oxygen content.2. The storage device as claimed in claim 1 , wherein compartments can be individually conditioned and are provided with individual adjusting means.3. The storage device as claimed in claim 2 , comprising a conditioning controller for adapting the conditions in compartments to each other such that an outlet of a compartment is operatively connected to an inlet of another compartment.4. The storage device as claimed in claim 1 , further comprising a gas generator.5. The storage device as claimed in claim 4 , wherein the gas generator comprises a nitrogen membrane.6. The storage device as claimed in claim 1 , wherein the cabinet is adapted so that it can be placed as build-in appliance in a kitchen.7. The storage device as claimed in claim 1 , comprising an external draining connection for drawing off conditioned gas.8. The storage device as claimed in claim 1 , comprising a filling opening for the supply of gas conditioning products or compositions.9. The storage device as claimed in claim 8 , wherein the filling opening comprises a ...

Hypoxic Fire Prevention System, Building Provided Therewith and Method Therefor

The present invention relates to a hypoxic fire prevention system and building construction and method therefor. The hypoxic fire prevention system comprises: a central supply container for hypoxic gas; a number of compartments connected to the container via connecting conduits; and at least one distributor provided in each compartment and operatively connected to a connecting conduit for the purpose of distributing the hypoxic gas. 1. A hypoxic fire prevention system , comprising:a central supply container for hypoxic gas;a number of compartments connected to the container via connecting conduits; andat least one distributor provided in each compartment and operatively connected to a connecting conduit for the purpose of distributing the hypoxic gas.2. The hypoxic fire prevention system as claimed in claim 1 , wherein the compartment comprises an open space.3. The hypoxic fire prevention system as claimed in claim 2 , wherein the open space comprises a sub-space.4. The hypoxic fire prevention system as claimed in claim 3 , wherein the sub-space comprises one or more seats.5. The hypoxic fire prevention system as claimed in claim 1 , wherein the compartment comprises a house claim 1 , a building or other building construction.6. The hypoxic fire prevention system as claimed in claim 1 , wherein the compartment is provided with a climate control system operatively connectable to the conduits with connecting means.7. The hypoxic fire prevention system as claimed in claim 1 , wherein the oxygen concentration in the container and/or the conduits is lower than about 16% and higher than about 13%.8. The hypoxic fire prevention system as claimed in claim 1 , wherein the supply container is a pressure container suitable for a pressure of at least 12 bar claim 1 , preferably at least 13 bar claim 1 , more preferably at least 16 bar claim 1 , and most preferably at least 100 or 200 bar.9. The hypoxic fire prevention system as claimed in claim 1 , wherein a gas sensor is ...

THERAPEUTIC HPV18 VACCINES

Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV18 and/or HPV16. 1. A nucleic acid molecule encoding a first polypeptide comprising SEQ ID NO: 20.2. The nucleic acid molecule of claim 1 , wherein the first polypeptide further comprises at least one epitope of a human papillomavirus (HPV) E2 protein.3. The nucleic acid molecule of claim 2 , wherein the first polypeptide comprises HPV18 E2 protein having a deletion or mutation in its DNA binding domain and/or a mutation in its transactivation domain.4. The nucleic acid molecule of claim 3 , wherein the first polypeptide comprises SEQ ID NO: 22.5. The nucleic acid molecule of claim 1 , comprising SEQ ID NO: 21.6. The nucleic acid molecule of claim 1 , comprising SEQ ID NO: 23.7. A vector comprising the nucleic acid molecule of claim 1 , wherein nucleic acid encoding the first polypeptide is operably linked to a promoter.8. The vector of claim 7 , wherein the vector is a recombinant adenovirus.9. The vector of claim 7 , wherein the promoter is operably coupled to a repressor operator sequence claim 7 , to which a repressor protein can bind in order to repress expression of the promoter in the presence of the repressor protein.10. The vector of claim 7 , further comprising:nucleic acid encoding a second polypeptide operably linked to a promoter, wherein the second polypeptide comprises SEQ ID NO: 1.11. The vector of claim 10 , wherein the second polypeptide comprises SEQ ID NO: 3 or SEQ ID NO: 5.12. The vector of claim 11 ,wherein the first polypeptide comprises SEQ ID NO: 22, andwherein the second polypeptide comprises SEQ ID NO: 3.13. A vaccine composition comprising:{'claim-ref': {'@idref': 'CLM-00007', 'claim 7'}, 'the vector of , and'}a pharmaceutically acceptable excipient.14. A vaccine composition comprising:{'claim-ref': {'@idref': 'CLM-00007', 'claim 7'}, 'the vector of ;'}a second vector comprising a nucleic acid molecule encoding a second ...

PORTABLE TEXTILE TREATMENT DEVICE WITH IMAGE SENSOR AND THERMAL INSULATION MEANS

The invention relates to a portable textile treatment device comprising a heatable soleplate () intended to be in contact with a textile (TXT) for treating the textile. The heatable soleplate () comprises a soleplate opening (H). The device comprises a module (MD) comprising an image sensor () for taking an image of the textile to be treated through the soleplate opening (H), and a control unit () configured for a) executing an algorithm stored in said portable textile treatment device, using the taken image as an input of the algorithm, to obtain a classification of the textile, and for b) controlling, based on the classification, at least one operating parameter of the portable textile treatment device. The module (MD) and the control unit () are integrated within the portable textile treatment device. The image sensor comprises an active surface sensitive to light which is oriented with respect to the surface of the heatable soleplate (), with an absolute value of an orientation angle being in the range from 15 to 70 degrees. The portable textile treatment device further comprises thermal insulation means arranged in-between the heatable soleplate () and the module (MD) for insulating the module (MD) from heat dissipated by the heatable soleplate (). 2. The portable textile treatment device according to claim 1 , wherein said thermal insulation means comprise:a first plastic cover extending over said heatable soleplate, said first plastic cover comprising a first opening, said module extending into said first opening,a first gasket arranged between said module and a first periphery of said first opening.3. The portable textile treatment device according to claim 2 , wherein said thermal insulation means further comprise:a first air gap is arranged between said heatable soleplate and said first plastic cover.4. The portable textile treatment device according to claim 3 , further comprising an opening for ventilating air in said first air gap outside the portable ...

THERAPEUTIC HPV16 VACCINES

Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV16. 1. A nucleic acid molecule encoding a polypeptide comprising SEQ ID NO:1.2. A nucleic acid molecule according to claim 1 , wherein the encoded polypeptide further comprises a leader sequence.3. The nucleic acid molecule of claim 1 , wherein the encoded polypeptide further comprises at least one epitope of a human papillomavirus (HPV) E2 protein.4. A nucleic acid molecule according to claim 3 , wherein the encoded polypeptide comprises HPV16 E2 protein that has a deletion or mutation in its DNA binding domain.5. A nucleic acid molecule according to claim 4 , wherein the encoded polypeptide comprises SEQ ID NO:3 or SEQ ID NO:5.6. The nucleic acid molecule of claim 1 , wherein the nucleic acid sequence is codon-optimized.7. The nucleic acid molecule of claim 1 , comprising SEQ ID NO:2.8. The nucleic acid molecule of claim 1 , comprising SEQ ID NO:4 or SEQ ID NO:6.9. A vector comprising the nucleic acid molecule of claim 1 , wherein a sequence encoding the polypeptide is operably linked to a promoter.10. A vector according to claim 9 , wherein the vector is a recombinant adenovirus.11. The vector of claim 9 , wherein the promoter is operably coupled to a repressor operator sequence claim 9 , to which a repressor protein can bind in order to repress expression of the promoter in the presence of said repressor protein.12. A vaccine composition comprising:{'claim-ref': {'@idref': 'CLM-00009', 'claim 9'}, 'the vector of , and'}a pharmaceutically acceptable excipient.13. A method of inducing an immune response against HPV in a subject claim 9 , the method comprising:{'claim-ref': {'@idref': 'CLM-00012', 'claim 12'}, 'administering to the subject the vaccine composition according to .'}14. The method according to claim 13 , wherein the vaccine composition is administered to the subject more than once.15. A method for treating a subject having persistent HPV ...

Providing A Chip Die With Electrically Conductive Elements

A method for providing position control information for controlling an impingement position of a laser beam for treatment of a chip die in a chip manufacturing process, comprises the steps of a) receiving a specification of positions (x,y) of a electrically conductive elements in the chip die, the positions having a first coordinate along a first direction (x) and a second coordinate (y) along a second direction in a plane defined by the chip die, said first and second direction being mutually transverse to each other, b) selecting a cluster of positions that is within a predetermined two-dimensional spatial range, wherein each pair of positions in the cluster at least has a first minimum difference in their first coordinates or a second minimum difference in their second coordinates and removing the next position from the ordered set, c) update the positions of the set of positions in accordance with an expected time needed to carry out the treatment for said cluster and a speed of a wafer comprising the chip die, d) repeating steps b-d until each of the positions in said set is assigned to a cluster.

Method and Apparatus for Cultivating Cells

In a method for cultivating cells, there is provided a container () comprising an at least partly flexible container wall structure (). The container is at least resting on a support structure (). Into the container's interior space () there is introduced a gas, a liquid medium () and a cell culture. At least part of said support structure together with the container thus resting thereon are being moved, thereby inducing motion to the liquid medium in the container. An upwardly facing outer surface structure of said support structure comprises an elongate downwardly recessed portion () which causes a gutter () in the container's bottom wall structure (). 1. A method for cultivating cells , comprising the steps of:providing a container comprising an at least partly flexible container wall structure defining an interior space of the container;placing the container in an apparatus such that the container thereby is at least resting on a support structure of the apparatus, wherein, when the container is thus resting, a container bottom wall structure is defined as the part of the container wall structure at the downwards facing side of the container and forming a bottom of the container, and wherein at least flexible bottom wall parts of said container bottom wall structure are contactingly lying against an upwardly facing outer surface structure of said support structure;introducing a gas, a liquid medium and a cell culture into said interior space;operating said apparatus such that at least part of said support structure together with the container thus resting thereon are moving, thereby inducing a motion to the liquid medium in the container, which motion contributes to cell growth of the cell culture;characterized in that,at least temporarily during said moving, said upwardly facing outer surface structure of said support structure of the apparatus comprises an elongate downwardly recessed portion which causes, also as a result of the flexibility of said bottom ...

THERAPEUTIC HPV16 VACCINES

Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV16. 1. A composition for treating a subject having persistent HPV infection , the composition comprising:a. a first vaccine composition comprising a recombinant adenovirus vector comprising a first nucleic acid sequence encoding a first polypeptide comprising the amino acid sequence of SEQ ID NO: 1, wherein the first nucleic acid sequence is operably linked to a first promoter, andb. a second vaccine composition comprising a recombinant pox virus vector comprising a second nucleic acid sequence encoding a second polypeptide comprising the amino acid sequence of SEQ ID NO: 1, wherein the second nucleic acid sequence is operably linked to a second promoter;wherein one of the first vaccine composition and the second vaccine composition is administered to the subject for priming vaccination and the other is administered to the subject for boosting administration.2. The composition of claim 1 , wherein the first vaccine composition is administered to the subject for priming vaccination and the second vaccine is administered to the subject for boosting administration.3. The composition of claim 1 , wherein the second vaccine composition is administered to the subject for priming vaccination and the first vaccine is administered to the subject for boosting administration.4. The composition of claim 1 , wherein the recombinant adenovirus vector of the first vaccine composition is a recombinant human adenovirus serotype 26 (Ad26) vector.5. The composition of claim 1 , wherein the recombinant pox virus vector is a Modified Vaccinia Ankara (MVA) vector.6. The composition of claim 1 , wherein the first and second polypeptides each independently further comprise a leader sequence.7. The composition of claim 1 , wherein the first and second polypeptides each independently further comprise at least one epitope of a human papillomavirus (HPV) E2 protein.8. The ...

SURVEY MANAGEMENT SYSTEMS AND METHODS WITH NATURAL LANGUAGE SUPPORT

Systems and methods for processing natural language survey responses are provided herein. Methods may include providing to a client a survey that comprises questions which are designed to elicit responses from a customer regarding customer satisfaction with a product, service, or provider, wherein the survey includes a graphical user interface for displaying the questions, the GUI comprising a speech input interface for at least one question, receiving from a client a natural language response for the at least one question, performing a textual analysis of the natural language response to determine textual content and a sentiment for the natural language response, and returning to the client the textual content, which is displayed on the GUI proximate the at least one question. 1. A method for processing natural language survey responses using a survey response system that comprises a processor and a memory for storing logic , the processor executing the logic to perform the method , comprising:providing to a client a survey that comprises questions which are designed to elicit responses from a customer regarding customer satisfaction with a product, service, or provider, wherein the survey includes a graphical user interface (GUI) for displaying the questions, the GUI comprising a speech input interface for at least one question;receiving from the client a natural language response for the at least one question;performing a textual analysis of the natural language response to determine textual content and a sentiment for the natural language response; andreturning to the client the textual content, which is displayed on the GUI proximate the at least one question.2. The method according to claim 1 , further comprising generating a provider dashboard that includes a representation of the sentiment for the at least one question.3. The method according to claim 2 , wherein the provider dashboard comprises a representation of a calculation of a plurality of sentiment ...

THERAPEUTIC HPV18 VACCINES

Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV18 and/or HPV16. 1. A recombinant pox virus vector comprising a nucleic acid sequence encoding a first polypeptide comprising the amino acid sequence of SEQ ID NO:20.2. The recombinant pox virus vector of claim 1 , wherein the recombinant pox virus vector is a recombinant Modified Vaccinia Ankara (MVA) vector.3. The recombinant MVA vector of claim 2 , wherein the first polypeptide further comprises at least one epitope of a human papillomavirus (HPV) E2 protein.4. The recombinant MVA vector of claim 3 , wherein the HPV E2 protein is an HPV18 E2 protein having a deletion or mutation in its DNA binding domain and/or a mutation in its transactivation domain.5. The recombinant MVA vector of claim 4 , wherein the first polypeptide comprises the amino acid sequence of SEQ ID NO:22.6. The recombinant pox virus vector of claim 1 , further comprising a nucleic acid sequence encoding a second polypeptide comprising the amino acid sequence of SEQ ID NO:1.7. The recombinant pox virus vector of claim 6 , wherein the recombinant pox virus vector is a recombinant MVA vector.8. The recombinant MVA vector of claim 7 , wherein the second polypeptide further comprises an HPV16 E2 protein having a deletion or mutation in its DNA binding domain and/or a mutation in its transactivation domain.9. The recombinant pox virus vector of claim 1 , wherein the nucleic acid sequence encoding the first polypeptide is operably linked to a promoter.10. A recombinant cell comprising the recombinant pox virus vector of .11. A recombinant cell comprising the recombinant MVA vector of .12. A recombinant cell comprising the recombinant pox virus vector of .13. A recombinant cell comprising the recombinant MVA vector of .14. A method for producing a recombinant pox virus vector claim 10 , comprising growing the recombinant cell of under conditions for production of the recombinant pox virus ...

METHOD FOR NON-DESTRUCTIVE TESTING OF SYNTHETIC ROPES AND ROPE SUITABLE FOR USE THEREIN

Methods for non-destructive testing of synthetic ropes is described, where the rope in use is subjected to X-ray, terahertz, permanent magnetic field or electromagnetic analysis to determine a pattern, the results of the analysis are compared with a standard pattern determined by the analysis, and the results of the comparison are used in determining whether the rope is fit for use; where the rope comprises at least two types of fibers, the first fiber type has a density which differs from the density of the second fiber type and the second fiber type is of the same polymer material as the first fiber type, but provided with a high-density or low-density material. Ropes suitable for use in this method are also described. 1. A method for non-destructive testing of synthetic ropes whereinthe rope in use is subjected to X-ray, terahertz, permanent magnetic field or electromagnetic analysis to determine a pattern,the results of the analysis are compared with a standard pattern determined by the analysis, and the rope comprises at least two types of fibers,', 'the first fiber type has a density which differs from the density of the second fiber type, and', 'the second fiber type is of the same polymer material as the first fiber type, but provided with a high-density or low-density material., 'the results of the comparison are used in determining whether the rope is fit for use; wherein'}2. The method according to claim 1 , wherein the high density material or low-density material is adhered to the first fiber type using glue or in a coating process.3. The method according to claim 1 , wherein the high density material comprises a metal and/or a derivative or alloy thereof.4. The method according to claim 1 , whereinthe standard pattern and the pattern of the rope in use are derived from a repeating oscillation pattern associated with the structure of the rope, andthe comparison between the two patterns is a measure for the change in the repeating oscillation pattern ...

Pad for Hot Beverage and Apparatus and Method for Manufacturing Thereof

The invention relates to a pad for use in a beverage machine for preparing a warm beverage, a system therefor, and a method for manufacturing such pads. The pad includes: a first sheet having a surface area, wherein the surface area of the first sheet is provided with flow passages that are positioned at or near the outer perimeter of the first sheet; and a second sheet having a surface area, wherein the surface area of the second sheet is provided with one or more flow passages that are positioned at or near the centre of the second sheet. The first sheet and the second sheet are connected to each other at or near the outer perimeter for forming an inner space for holding the raw material that is usable for preparing the beverage. Substantially the entire surface area of the first and/or second sheet is impermeable to the flow of pressurized liquid. The impermeable surface area and the flow passages cooperate for forcing the flow of pressurized liquid to flow substantially in a direction that is parallel to the surface areas through the raw material in the pad.

HPV VACCINES

The present invention relates to novel vaccines against Human papillomavirus (HPV) infections, based on recombinant capsid-display adenovirus vectors. Described are capsid modified replication deficient adenovirus particles encoding and displaying multiple HPV L2 antigenic fragments, via a minor capsid protein IX, and their use for eliciting an immune response in order to provide protection against infections from multiple HPV types. 1. A recombinant adenoviral vector encoding a polypeptide comprising a capsid protein IX fused to an antigen wherein said antigen comprises 3 to 5 consecutive amino acid motifs , wherein each motif is about 20 to about 40 amino acids long and wherein each motif comprises an antigenic fragment of a HPV L2 protein from a different HPV type.2. The recombinant adenoviral vector according to claim 1 , wherein at least one of the motifs comprises an antigenic fragment which comprises amino acid residues 17-36 of a HPV L2 protein.3. The recombinant adenoviral vector according to claim 1 , wherein the HPV L2 protein is from a HPV type selected from the group consisting of HPV types 6 claim 1 , 11 claim 1 , 16 claim 1 , 18 claim 1 , 31 claim 1 , 33 claim 1 , 35 claim 1 , 39 claim 1 , 45 claim 1 , 52 claim 1 , 56 claim 1 , 58 claim 1 , 68 claim 1 , 73 and 82.4. The recombinant adenoviral vector according to claim 1 , wherein said antigen comprises 3 consecutive amino acid motifs which comprise the amino acid residues 17-36 of a HPV L2 protein of the HPV types 45 claim 1 , 18 and 16 claim 1 , respectively.5. The recombinant adenoviral vector according to claim 4 , wherein said antigen comprises the amino acid sequence of SEQ ID NO:1.6. The recombinant adenoviral vector according to claim 1 , wherein said antigen comprises 4 consecutive amino acid motifs which comprise the amino acid residues 17-36 of a HPV L2 protein of the HPV types 31 claim 1 , 45 claim 1 , 18 and 16 respectively; a HPV L2 protein of the HPV types 33 claim 1 , 45 claim 1 , 18 ...

System for Making a Hot Beverage with Substantially Horizontal Throughflow and Method for Making a Hot Beverage

The invention relates to a system and a method for making a hot beverage such as coffee. The system according to the invention includes a raw material container in which raw material for the hot beverage is arrangeable. The raw material container is provided with a liquid inlet, and an outlet with a substantially horizontal flow through the raw material. A nozzle assembly is connected operatively to the outlet and provided with an inlet, an air inlet and a nozzle. An outflow is connected operatively to the nozzle for delivery of the hot beverage. 116.-. (canceled)17. A system for making a hot beverage , comprising:a raw material container in which raw material for the hot beverage is arrangeable, wherein the raw material container is provided with:a liquid inlet, andan outlet for a mixture of raw material and liquid, wherein the liquid inlet and the outlet are positioned such that a liquid can flow substantially horizontally through the raw material;a nozzle assembly connected operatively to the outlet and provided with:an inlet for the mixture of raw material and the liquid,an air inlet for admitting air during throughflow of the nozzle assembly, wherein the air inlet comprises an inlet configured to introduce or admix air during throughflow of the nozzle assembly, anda nozzle, wherein the nozzle assembly is provided with a configuration wherein air is admixed as the mixture flows through; andan outflow connected operatively to the nozzle for delivery of the hot beverage.18. The system as claimed in claim 17 , wherein the liquid inlet of the raw material container is positioned substantially centrally and the outlet is positioned substantially at or close to the periphery of the raw material container.19. The system as claimed in claim 17 , wherein the liquid inlet of the raw material container comprises an entry plate with passages in or close to the centre of the entry plate.20. The system as claimed in claim 17 , wherein the outlet of the raw material container ...

THERAPEUTIC HPV16 VACCINES

Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV16. 1. A recombinant adenovirus vector comprising an operator-containing promoter sequence operably linked to a nucleic acid sequence encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:1.2. The recombinant adenovirus vector of claim 1 , wherein the operator-containing promoter sequence comprises a CMV promoter and a tetracyclin operon operator (TetO) sequence.3. The recombinant adenovirus vector of claim 1 , wherein the encoded polypeptide further comprises at least one epitope of a human papillomavirus (HPV) E2 protein.4. The recombinant adenovirus vector of claim 3 , wherein the encoded polypeptide comprises HPV16 E2 protein that has a deletion or mutation in its DNA binding domain.5. The recombinant adenovirus vector of claim 4 , wherein the encoded polypeptide comprises the amino acid sequence of SEQ ID NO:3 or SEQ ID NO:5.6. The recombinant adenovirus vector of claim 1 , wherein the nucleic acid molecule comprises the polynucleotide sequence of SEQ ID NO:2 claim 1 , SEQ ID NO:4 or SEQ ID NO:6.7. The recombinant adenovirus vector of claim 1 , being a recombinant human adenovirus serotype 26 (Ad26) vector.8. The recombinant adenovirus vector of claim 2 , wherein the TetO sequence comprises SEQ ID NO: 11.9. A recombinant cell comprising the recombinant adenovirus vector of .10. The recombinant cell of claim 9 , wherein the operator-containing promoter sequence comprises a CMV promoter and a TetO operator sequence claim 9 , and the recombinant cell expresses tetracyclin operon repressor protein (TetR).11. The recombinant cell of claim 10 , wherein the cell is a PER.C6 cell stably transfected with a nucleic acid sequence encoding the amino acid sequence of SEQ ID NO:15 and further transfected with the recombinant adenovirus vector.12. A method for producing a recombinant adenovirus vector claim 10 , comprising growing a recombinant ...

THERAPEUTIC HPV16 VACCINES

Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV16. 1. A recombinant pox virus vector comprising a nucleic acid sequence encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:1 , wherein the nucleic acid sequence is operably linked to a promoter.2. The recombinant pox virus vector of claim 1 , wherein the pox virus vector is a Modified Vaccinia Ankara (MVA) vector.3. The recombinant MVA vector of claim 2 , wherein the encoded polypeptide further comprises at least one epitope of a human papillomavirus (HPV) E2 protein.4. The recombinant MVA vector of claim 3 , wherein the encoded polypeptide comprises a HPV16 E2 protein that has a deletion or mutation in its DNA binding domain.5. The recombinant MVA vector of claim 4 , wherein the encoded polypeptide comprises the amino acid sequence of SEQ ID NO:3 or SEQ ID NO:5.6. The recombinant pox virus vector of claim 1 , wherein the encoded polypeptide further comprises at least one epitope of a human papillomavirus (HPV) E2 protein.7. The recombinant pox virus vector of claim 6 , wherein the encoded polypeptide comprises a HPV16 E2 protein that has a deletion or mutation in its DNA binding domain.8. A recombinant cell comprising the recombinant pox virus vector of .9. A recombinant cell comprising the recombinant MVA vector of .10. A method for producing a recombinant pox virus vector claim 8 , comprising growing the recombinant cell of under conditions for production of the recombinant pox virus vector.11. A vaccine composition comprising the recombinant pox virus vector of .12. A vaccine composition comprising the recombinant MVA vector of .13. A vaccine composition comprising the recombinant MVA vector of .14. A method of generating an immune response against HPV16 claim 11 , comprising administering to a subject in need thereof the vaccine composition of .15. The method of claim 11 , further comprising administering to the subject a second ...

THERAPEUTIC HPV18 VACCINES

Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV18 and/or HPV16. 1. A recombinant adenovirus vector comprising an operator-containing promoter sequence operably linked to a nucleic acid sequence encoding a polypeptide comprising the amino acid sequence of SEQ ID NO: 20.2. The recombinant adenovirus vector of claim 1 , wherein the operator-containing promoter sequence comprises a CMV promoter and a tetracyclin operon operator (TetO) sequence.3. The recombinant adenovirus vector of claim 1 , wherein the encoded polypeptide further comprises at least one epitope of a human papillomavirus (HPV) E2 protein.4. The recombinant adenovirus vector of claim 3 , wherein the encoded polypeptide comprises HPV18 E2 protein that has a deletion or mutation in its DNA binding domain and/or a mutation in its transactivation domain.5. The recombinant adenovirus vector of claim 4 , wherein the encoded polypeptide comprises the amino acid sequence of SEQ ID NO: 22.6. The recombinant adenovirus vector of claim 1 , wherein the nucleic acid molecule comprises the polynucleotide sequence of SEQ ID NO: 21 or SEQ ID NO: 23.7. The recombinant adenovirus vector of claim 1 , being a recombinant human adenovirus serotype 26 (Ad26) vector.8. The recombinant adenovirus vector of claim 2 , wherein the TetO sequence comprises SEQ ID NO: 11.9. A recombinant cell comprising the recombinant adenovirus vector of .10. The recombinant cell of claim 9 , wherein the operator-containing promoter sequence comprises a CMV promoter and a TetO operator sequence claim 9 , and the recombinant cell expresses tetracyclin operon repressor protein (TetR).11. The recombinant cell of claim 10 , wherein the cell is a PER.C6 cell stably transfected with a nucleic acid sequence encoding the amino acid sequence of SEQ ID NO: 15 and further transfected with the recombinant adenovirus vector.12. A method for producing a recombinant adenovirus vector claim 10 , ...

Storage device for fresh products, and tablet and method therefor

The present invention relates to a storage device for fresh products and/or perishable produce and a method for storing fresh products, comprising: a cabinet provided with an access door and/or flap; one or more substantially gastight compartments arranged in the cabinet and provided with at least one gas inlet and one gas outlet; and conditioning means suitable for conditioning the climate in the compartment, wherein the conditioning comprises of providing desired gas conditions, including oxygen content.

Method and device for the carrying out of a microbiological or enzymatic process

To improve the yield and/or reduce the energy cost in carrying out a microbiological or enzymatic process in a reactor and to make the reaction conditions essentially independent of the size of the reactor, it is proposed to make use, as a reactor, of an endless circulation tube in which the reaction components are circulated essentially according to a plug flow and in this process are fed through one or more in-line mixers fitted inside the tube. This method and reactor are suitable in particular for the preparation by fermentation of polysaccharides, especially xanthan, in which water, a production medium containing one or more sugars and nutrient satts and an inoculating material of a suitable aerobic bacterium are introduced into the said reactor tube and exposed to fermentation with air being supplied. Preferably the concentration of a reaction component or a value derived therefrom is measured at at least one point and the reaction velocity is regulated on the basis of the said measurement within critical limits.

Apparatus for controlling and performing a microbiological or enzymatic plug flow process

To improve the yield and/or reduce the energy cost in carrying out a microbiological or enzymatic process in a reactor and to make the reaction conditions essentially independent of the size of the reactor, it is proposed on make use, as a reactor, of an endless circulation tube in which the reaction components are circulated essentially according to a plug flow and in this process are fed through one or more in-line mixers fitted inside the tube. This method and reactor are suitable in particular for the preparation by fermentation of polysaccharides, especially xanthan, in which water, a production medium containing one or more sugars and nutrient salts and an inoculating material of a suitable aerobic bacterium are introduced into the the reactor tube and exposed to fermentation with air being supplied. Preferably the concentration of a reaction component or a value derived therefrom is measured at at least one point and the reaction velocity is regulated on the basis of the the measurement within critical limits.

An active carrier for carrying a wafer and method for release

In the field of release and pickup of ultrathin semiconductor dies, there is provided an active carrier (1) for carrying a wafer (20) and a method for using such a carrier (1). The wafer (20) comprises a particular die arrangement (P). The active carrier (1) comprises a base plate (2) and a number of energizers (7) constructed on or in this base plate (2). The energizers (7) are laid out in an arrangement corresponding to the die arrangement (P). The energizers (7) can locally energize an adhesive layer (3) in proximity to a selected die (14) from the die arrangement (P). By this local energizing of the adhesive layer (P), the selected die is loosened from the adhesive layer (3). Furthermore the active carrier (1) comprises a plurality of externally addressable contacts (12) and conduction pathways (9). The conduction pathways (9) connect the contacts (12) to the energizers (7) thereby allowing individual control over said energizers (7) by addressing said contacts (12).

An active carrier for carrying a wafer and method for release

In the field of release and pickup of ultrathin semiconductor dies, there is provided an active carrier (1) for carrying a wafer (20) and a method for using such a carrier (1). The wafer (20) comprises a particular die arrangement (P). The active carrier (1) comprises a base plate (2) and a number of energizers (7) constructed on or in this base plate (2). The energizers (7) are laid out in an arrangement corresponding to the die arrangement (P). The energizers (7) can locally energize an adhesive layer (3) in proximity to a selected die (14) from the die arrangement (P). By this local energizing of the adhesive layer (P), the selected die is loosened from the adhesive layer (3). Furthermore the active carrier (1) comprises a plurality of externally addressable contacts (12) and conduction pathways (9). The conduction pathways (9) connect the contacts (12) to the energizers (7) thereby allowing individual control over said energizers (7) by addressing said contacts (12).

Therapeutic HPV16 vaccines

The invention provides designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV 16. These polypeptides comprise essentially all possible T-cell epitopes of HPV 16 oncoproteins E6 and E7, but nevertheless have a strongly reduced (as compared to wt E6 and E7), up to non-detectable, transforming activity, by comprising fragments of the E6 and E7 proteins that have been re-ordered, while at the same time containing a minimized number of undesired neo-epitopes. The invention provides a nucleic acid molecule encoding a polypeptide comprising a sequence as set forth in SEQ ID NO: 1. In certain embodiments, the encoded polypeptide further comprises at least one epitope of a human papillomavirus (HPV) E2 protein, for example an HPV 16 E2 protein.

Therapeutic hpv18 vaccines.

Construcciones de ácidos nucleicos y polipéptidos de diseño que se pueden utilizar como vacunas terapéuticas contra el HPV18 y/o el HPV1.

Hpv vaccines

The present invention relates to novel vaccines against Human papillomavirus (HPV) infections, based on recombinant capsid-display adenovirus vectors. Described are capsid modified replication deficient adenovirus particles encoding and displaying multiple HPV L2 antigenic fragments, via a minor capsid protein IX, and their use for eliciting an immune response in order to provide protection against infections from multiple HPV types.

Therapeutic HPV16 vaccines

Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV16.

Therapeutic HPV18 vaccines

Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV18 and/or HPV16.

Therapeutic HPV16 vaccines

Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV16.

Therapeutic HPV16 vaccines

Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV16.

Therapeutic HPV16 vaccines

Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV16.

Therapeutic HPV18 vaccines

Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV18 and/or HPV16.

Greenhouse system

Greenhouse system, comprising illumination means (2) for the illumination of plants (3) etc. inside the greenhouse (1) for the benefit of plant growth, sensor means (7,8) for measuring one or more variables which are directly or indirectly related to the growth, development or health of those plants or relevant groups of them, and control means (9,11) which are arranged to control the illumination means in dependency of the output of the sensor means. The illumination means and control means are arranged to vary the intensity and the spectral distribution of the light emitted by the illumination means. The illumination means may comprise SBLED arrays, the emitted light of which mainly covers a spectral distribution which is relevant for the plant growth, pest and/or disease control etc. The emitted light may be pulsed light, the pulse characteristics being variable by the control means in dependency of the output of the sensor means. The control means are arranged to interpret the relevant variables measured by the sensor means and to assess the actual and/or expected growth of the relevant plants, and to control the intensity and/or the spectral distribution of the light emitted by the illumination means to those relevant plants in accordance with the assessment result. Some sensors (8) may be provided for measuring the intensity and/or spectral distribution of the actual light in the greenhouse, other sensors (7) for measuring one or more plant dimensions of the relevant plants or groups of plants. The illumination means (2) may comprise heat collection means which are able to be connected to heating or air conditioning means inside or outside the relevant greenhouse.

Greenhouse system

Greenhouse system, comprising illumination means (2) for the illumination of plants (3) etc. inside the greenhouse (1) for the benefit of plant growth, sensor means (7, 8) for measuring one or more variables which are directly or indirectly related to the growth, development or health of those plants or relevant groups of them, and control means (9, 11) which are arranged to control the illumination means in dependency of the output of the sensor means. The illumination means and control means are arranged to vary the intensity and the spectral distribution of the light emitted by the illumination means. The illumination means may comprise SBLED arrays, the emitted light of which mainly covers a spectral distribution which is relevant for the plant growth, pest and/or disease control etc. The emitted light may be pulsed light, the pulse characteristics being variable by the control means in dependency of the output of the sensor means. The control means are arranged to interpret the relevant variables measured by the sensor means and to assess the actual and/or expected growth of the relevant plants, and to control the intensity and/or the spectral distribution of the light emitted by the illumination means to those relevant plants in accordance with the assessment result. Some sensors (8) may be provided for measuring the intensity and/or spectral distribution of the actual light in the greenhouse, other sensors (7) for measuring one or more plant dimensions of the relevant plants or groups of plants. The illumination means (2) may comprise heat collection means which are able to be connected to heating or air conditioning means inside or outside the relevant greenhouse.

Greenhouse system

Greenhouse system may comprise an illumination, a sensor, and a controller. The illumination and controller are arranged to vary the intensity and the spectral distribution of the light emitted by the illumination. The emitted light may be pulsed light, the pulse characteristics being variable by the controller in dependency of the output of the sensor. The controller is arranged to interpret the relevant variables measured by the sensor and to assess the actual and/or expected growth of the relevant plants, and to control the intensity and/or the spectral distribution of the light emitted by the illumination. Some sensors may be provided for measuring the intensity and/or spectral distribution of the actual light in the greenhouse, other sensors for measuring plant dimensions of the relevant plants or plant groups. The illumination may comprise a heat collector which can be connected to heating or air conditioning inside or outside the greenhouse.

SEAT BELT, LOCK, PLUG AND PLUG ADAPTER, AND METHOD AND DEVICE FOR THIS.

THERAPEUTIC HPV16 VACCINES

WINDSCREEN BREAKER SYSTEM, SAFETY SYSTEM AND VEHICLE EQUIPPED FOR THIS AND METHOD FOR THIS.

Method for non-destructive testing of synthetic ropes and rope suitable for use therein

Method for non-destructive testing of synthetic ropes wherein the rope in use is subjected to X-ray, terahertz, permanent magnetic field or electromagnetic analysis to determine a pattern, the results of the analysis are compared with a standard pattern determined by the analysis, and the results of the comparison are used in determining whether the rope is fit for use, wherein the rope comprises at least two types of fibers, wherein the first fiber type has a density which differs from the density of the second fiber type and wherein the second fiber type is of the same polymer material as the first fiber type, but provided with a high-density or low-density material. Ropes suitable for use in this method are also claimed.

Therapeutic vaccines against hpv18 and / or hpv16

La presente invención proporciona moléculas de ácido nucleico que codifican polipéptidos que comprenden esencialmente todos los posibles epitopes para célula T de las oncoproteínas de HPV16 o HPV18 E6 y E7, pero sin embargo tienen una actividad transformante fuertemente reducida (en comparación con E6 y E7 wt), hasta no detectable, por comprender fragmentos de las proteínas E6 y E7 que se han reordenado, mientras que al mismo tiempo contienen un número minimizado de neo epitopes fuertes no deseados. La invención se relaciona con el campo de la medicina y más en particular con construcciones de ácidos nucleicos y polipéptidos que se pueden usar en vacunas terapéuticas contra el papilomavirus humano tipo 18, y/o tipo 16. The present invention provides nucleic acid molecules that encode polypeptides that comprise essentially all possible T cell epitopes of the HPV16 or HPV18 oncoproteins E6 and E7, but nevertheless have strongly reduced transforming activity (compared to E6 and E7 wt) , even not detectable, by comprising fragments of the E6 and E7 proteins that have been rearranged, while at the same time containing a minimized number of unwanted strong neo epitopes. The invention relates to the field of medicine and more particularly to nucleic acid and polypeptide constructs that can be used in therapeutic vaccines against human papillomavirus type 18, and / or type 16.

Optical rotary joints, methods of mounting same in a properly-aligned manner, and optical reflector assemblies for use therein

The present invention relates generally to optical rotary joints (35) for enabling optical communication between a rotor and a stator, improved method s of mounting such optical rotary joints on supporting structures such that the rotor and stator remain properly aligned, and to improved optical reflector assemblies for use in such optical rotary joints. The improved optical rotary joint enables optica l communication between a rotor and a stator, said rotor having a longitudinal axis, and comprises: at least one optical source (36) mounted on one of said rotor and stator for transmitting an optical signal in a radial direction with respect to the longitudinal axis; at least one first reflector (38) mounted on the other of said rotor and stator for reflecting the optical signal transmitted from the source, said fust reflect or comprising a concave first reflective surface (44), a line (L) in a plane taken through said first reflective surface being configured as a portion of an ellipse having first and second focal points (F1, F2), the first focal point being positioned substantially coincident with said rotor axis; a second reflector (39) having a second reflective surface (45) configured as a portion of a cone and positioned at the second focal point o f the elliptical surface for receiving light reflected from said first reflective surface and for reflecting light in a different direction as a function of the apex angle of the second reflective surface; and a receiver (40) arranged to receive light reflected by the second reflective surface.

Method and apparatus for cultivating cells utilizing wave motion

An apparatus for cultivating cells utilizing wave motion comprising a container, a retaining member configured to retain the container, a drive assembly for swiveling the container with respect to the substantially horizontal pivot axis and to swivel, such that during swiveling the pivot axis follows a cyclical closed-loop path.

Discharge tube

Therapeutic HPV18 vaccines

Abstract The invention provides designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV18 and/or HPV16.

Therapeutic hpv18 vaccines

Piece of furniture provided with outward foldable table leaf and method therefor

The invention relates to a piece of furniture provided with an outward foldable table leaf and a method therefor. The table leaf herein comprises an outer end coupled to the piece of furniture for pivoting around a substantially horizontal pivot axis by means of a first coupling means such that the table leaf is pivotable between a substantially vertical position and a substantially horizontal position, characterized in that a second coupling means is present for holding the table leaf in the vertical position, wherein the first coupling means and the second coupling means are embodied such that in the vertical position the table leaf is slidable in a substantially horizontal direction along the piece of furniture, wherein the second coupling means holds the table leaf in the vertical position such that the table leaf is prevented from being able to fold outward unintentionally during sliding thereof.

Method for non-destructive testing of systhetic ropes and rope suitable for use therein

Therapeutic hpv16 vaccines

The invention provides designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV16.

THERAPEUTIC HPV16 VACCINES

L 'invention concerne des constructions d' acides nucléiques et des polypeptides de concepteur pouvant être utilisés en tant que vaccins thérapeutiques contre hpv16.

Lithographic apparatus and method of cleaning a surface of an immersion lithographic apparatus

A method of cleaning a lithography apparatus using an aerosol spray is described. The spray from the aerosol is contained in a space.

Heating and cooling zone control system

The present invention relates to a HVAC wireless zone control system comprising a plurality of air distribution registers at the discharge ends of the HVAC air flow ducts, one or more slave thermostats wirelessly communicating with registers within its zone to control the opening and closing of registers, and a master thermostat for controlling the air handling appliance and wirelessly communicating with each slave thermostat.

Process for the introduction of alkali or alkaline earth metals into discharge tubes and others

Personal care appliance for treatment of a body part with means for dispensing an additive onto said body part to be treated

The invention relates to a personal care appliance (1) such as a shaver, toothbrush or hairstyler for treatment of a body part, wherein an additive is applied to the body part to be treated in order to facilitate or enhance treatment thereof. To that end the appliance comprises a reservoir (10) for holding an additive, means (12) for dispensing said additive onto the body part and control means (20) for controlling the dispense means. The control means are arranged for automatically controlling the dispense means to dispense a desired dispense rate according to a predetermined dispense profile, which profile is adapted to a user's needs and/or particular treatment conditions.

Method and apparatus for cultivating cells utilizing wave motion

A method for cultivating cells utilizing wave motion comprises the steps of: - providing a container (2; 2A; 2B); - introducing a gas containing oxygen, a liquid medium (3) and a cell culture into the container; - moving the container such that the container swivels with respect to a substantially horizontal pivot axis (5; 5B; 55) to thereby induce a wave motion to the liquid medium (3) in the container, which wave motion contributes to the necessary oxygen transfer and mixing required for cell growth. During said swivelling of the container said pivot axis (5; 5B; 55) follows a cyclical closed-loop path (6; 6B; 56).

Discharge tubes with inert gas filling

TREATMENT METHOD FOR WOOD PRODUCTS AND WOOD PRODUCTS ALREADY TREATED.

Optical rotary joints

Optical reflector assemblies for use in optical rotary joints

Droplet selection mechanism

A method and droplet selection device are provided for a continuous printer for selectively ejecting a second droplet (61) and to have it collided with a predefined first droplet (62). In particular, the device comprises a first droplet ejection system (10) arranged to generate a continuous stream of first droplets (6) from a fluid (60) jetted out of an outlet channel (5); and a second droplet ejection system (100) arranged to generate second droplets (61) for colliding the second droplets into the first droplets so as to selectively deflect the first droplets from a predefined printing trajectory. The second droplet ejection system comprises a control circuit (11) to selectively eject the second droplet and to have it collided with a predefined first droplet.

Droplet selection mechanism

A method and droplet selection device are provided for a continuous printer for selectively deflecting a droplet from a predetermined printer trajectory. In particular, a droplet selection device is provided for a continuous printer, comprising a droplet ejection system (10) arranged to generate a continuous stream of droplets (6) from a first fluid jetted out of an outlet channel (5), and a jet system (70) arranged to generate a second jet (61) for colliding the jet into the stream of droplets. The jet system comprises a deflector (71), to selectively deflect the second jet into the continuous stream of droplets, so as to selectively deflect the droplets from a predefined printing trajectory.

Plastic granulated material with non-dispersed electrically conductive fibre bundles

The invention relates to a plastic granulated material containing electrically conductive fibres, the degree of dispersion of which fibres in the granulated material is 0.10 at most, the degree of dispersion being the reciprocal value of the volume fraction in % of a granule occupied by electrically conductive fibre bundles and measured according to the threshold value method. Moulding compounds produced from the granules according to the invention have very high EMI values.

Method for non-destructive testing of synthetic ropes and rope suitable for use therein

Method for non-destructive testing of synthetic ropes wherein the rope in use is subjected to X-ray, terahertz, permanent magnetic field or electromagnetic analysis to determine a pattern, the results of the analysis are compared with a standard pattern determined by the analysis, and the results of the comparison are used in determining whether the rope is fit for use, wherein the rope comprises at least two types of fibers, wherein the first fiber type has a density which differs from the density of the second fiber type and wherein the second fiber type is of the same polymer material as the first fiber type, but provided with a high-density or low-density material. Ropes suitable for use in this method are also claimed.

Method and apparatus for applying a material on a substrate

The invention provides a method for applying a material onto a substrate using a droplet printing technique wherein a gas stream is released into the direction of a substrate, which gas stream comprises a carrier gas and droplets of a suspension of the material or droplets of a solution of a precursor of the material or droplets of a precursor of the material as such, whereby the droplets in the gas stream are first maintained in a steady flow and subsequently in a converging flow before the droplets are contacted with the substrate. The invention further provides an apparatus for carrying out said method.

Method and apparatus for cultivating cells utilizing wave motion

Discharge tubes for multiphase rectification of alternating current

Droplet selection mechanism

A method and droplet selection device are provided for a continuous printer for selectively ejecting a second droplet and to have it collided with a predefined first droplet. In particular, the device comprises a first droplet ejection system arranged to generate a continuous stream of first droplets from a fluid jetted out of an outlet channel; and a second droplet ejection system arranged to generate second droplets for colliding the second droplets into the first droplets so as to selectively deflect the first droplets from a predefined printing trajectory. The second droplet ejection system comprises a control circuit to selectively eject the second droplet and to have it collided with a predefined first droplet.

Therapeutic hpv18 vaccines

The invention provides designer nucleic acid constructs and polypeptides that used as therapeutic vaccines against HPV18 and/or HPV16.

Therapeutic HPV18 Vaccines

The invention provides designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV18 and/or HPV16.

Droplet selection mechanism

A method and droplet selection device are provided for a continuous printer for selectively deflecting a droplet from a predetermined printing trajectory. In particular, a droplet selection device is provided for a continuous printer, comprising a droplet ejection system arranged to generate a continuous stream of droplets from a first fluid jetted out of an outlet channel; and a jet system arranged to generate a second jet for colliding the jet into the stream of droplets. The jet system comprises a deflector to selectively deflect the second jet into the continuous stream of droplets, so as to selectively deflect the droplets from a predefined printing trajectory.

Closure means allowing venting of a beverage container

Closure means 1 for sealing a carbonated beverage container 4 capable of relieving an excess of pressure therein, comprises one-way valve moans 13 arranged to allow pressurized gas to enter the container from a pump (25, fig 2) which the closure moans is adapted to receive, and pressure relief means 21 arranged to allow pressurized gas to escape from the container when it becomes excessively pressurized. The pressure relief means may be provided separately (54, fig 4) or as part of the valve means. When the pressure relief means is part of the valve means it may consist of a frustoconical portion 17 which is placed in a frusto-conical recess 18. As the pressure increases within the container the frusto-conical portion is forced up into the recess to a point where a by pass channel 19, 20 allows gas to escape before the frusto-conical portion returns to its original position by means of the resilient material of the one-way valve. Valve means 13 allows pressurised gas entering the container through inlet 11 to pass around its flange cap 14, while in another embodiment valve means (53, fig 4) allows the gas to enter through a slot in the valve means (59, fig 5b), a similar slot in the pressure relief means (54, fig 4) allowing escape of gas. <IMAGE>

METHOD AND REACTION BOILER FOR THE PRODUCTION OF POLYSACCHARIDES BY FERMENTATION, ESPECIALLY XANTHAN.

For the fermentative preparation of polysaccharides, in particular xanthane, water, production medium (sugars, nutrient salts), and an inoculation material of a suitable aerobic bacterium are mixed in a reactor as reaction components, the production medium being exposed to fermentation while an oxygen-containing gas is being supplied. The object is to avoid the usual low yield of such a process and to reject an expensive and sensitive alternative construction (circulation tube). According to the invention, the reaction components are introduced into a reactor vessel in a circulating flow by means of pumping means, which circulating flow comprises a rising flow and a descending flow which are separated from each other by one or more partitions disposed in the reactor vessel. The mixing is brought about because the rising flow and/or the descending flow is passed essentially in the form of a plug flow through one or more static in-line mixers.

Method and apparatus for applying a material on a substrate

The invention provides a method for applying a material onto a substrate using a droplet printing technique wherein a gas stream is released into the direction of a substrate, which gas stream comprises a carrier gas and droplets of a suspension of the material or droplets of a solution of a precursor of the material or droplets of a precursor of the material as such, whereby the droplets in the gas stream are first maintained in a steady flow and subsequently in a converging flow before the droplets are contacted with the substrate. The invention further provides an apparatus for carrying out said method.

Product dispensing system and method

Product dispensing system for dispensing a viscous product from a flexible tubular pouch at a controlled temperature. A receiving tube defines two elongated slots extending along opposite sides of the receiving tube. A linear guidance and spindle mechanism comprises two linear members, each linear member extending along and to the outside of one of the elongated slots. Herein either both linear members are each embodied as a motor driven spindle or wherein one linear member is embodied as a motor driven spindle and the other linear member is embodied as a stationary linear guide member. The dispenser device comprises a bridge piece extending across the linear members, said bridge piece passing through the elongated slots and being connected to each linear member. Each connection to a spindle is embodied to operatively connect the bridge piece to the spindle so that the bridge piece is movable by the one or two spindles in the longitudinal direction of the receiving tube. A plunger is supported by the bridge piece.

System for making a hot beverage with substantially horizontal throughflow and method for making a hot beverage

The invention relates to a system and a method for making a hot beverage such as coffee. The system according to the invention comprises: - a raw material container in which raw material for the hot beverage is arrangeable, wherein the raw material container is provided with a liquid inlet, and an outlet with a substantially horizontal flow through the raw material; - a nozzle assembly connected operatively to the outlet and provided with an inlet, an air inlet and a nozzle; and - an outflow connected operatively to the nozzle for delivery of the hot beverage.

FERMENTATION REACTOR AND USE OF THIS FOR THE PREPARATION OF POLYSACCHARIDES, SPECIFICALLY XANTAN.

Pad for hot beverage and apparatus and method for manufacturing thereof

The invention relates to a pad for use in a beverage machine for preparing a warm beverage, a system therefor, and a method for manufacturing such pads. The pad comprises: - a first sheet having a surface area, wherein the surface area of the first sheet is provided with flow passages that are positioned at or near the outer perimeter of the first sheet; - a second sheet having a surface area, wherein the surface area of the second sheet is provided with one or more flow passages that are positioned at or near the centre of the second sheet; and wherein the first sheet and the second sheet are connected to each other at or near the outer perimeter for forming an inner space for holding the raw material that is usable for preparing the beverage, wherein substantially the entire surface area of the first and/or second sheet is impermeable to the flow of pressurized liquid, and wherein the impermeable surface area and the flow passages cooperate for forcing the flow of pressurized liquid to flow substantially in a direction that is parallel to the surface areas through the raw material in the pad.

Method and apparatus for applying a material on a substrate

The invention provides a method for applying a material onto a substrate using a droplet printing technique wherein a gas stream is released into the direction of a substrate, which gas stream comprises a carrier gas and droplets of a suspension of the material or droplets of a solution of a precursor of the material or droplets of a precursor of the material as such, whereby the droplets in the gas stream are first maintained in a steady flow and subsequently in a converging flow before the droplets are contacted with the substrate. The invention further provides an apparatus for carrying out said method.

THERAPEUTIC VACCINES FOR HPV16

Construcciones de ácidos nucleicos y polipéptidos de diseño que se pueden utilizar como vacunas terapéuticas contra el HPV16. Reivindicación 1: Una molécula de ácido nucleico caracterizada porque codifica un polipéptido que comprende la SEQ ID Nº 1. Nucleic acid and polypeptide design constructs that can be used as therapeutic vaccines against HPV16. Claim 1: A nucleic acid molecule characterized in that it encodes a polypeptide comprising SEQ ID No. 1.

Discharge tube with inclosed arc discharge

Therapeutic hpv16 vaccines

The invention provides designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV 16. These polypeptides comprise essentially all possible T-cell epitopes of HPV 16 oncoproteins E6 and E7, but nevertheless have a strongly reduced (as compared to wt E6 and E7), up to non-detectable, transforming activity, by comprising fragments of the E6 and E7 proteins that have been re-ordered, while at the same time containing a minimized number of undesired neo-epitopes. The invention provides a nucleic acid molecule encoding a polypeptide comprising a sequence as set forth in SEQ ID NO: 1. In certain embodiments, the encoded polypeptide further comprises at least one epitope of a human papillomavirus (HPV) E2 protein, for example an HPV 16 E2 protein.

Niederfrequenzendverstaerkerstufe mit Schirmgitterroehre

Electric discharge tube

Interconnect structure and method for producing same

There is provided a three-dimensional interconnect structure for micro- electronic devices and a method for producing such an interconnect structure. The method comprises a step wherein a backbone structure 100 is manufactured using an additive layer-wise manufacturing process 310. The backbone structure 100 comprises a three-dimensional cladding skeleton 104 and a support structure 101. The cladding skeleton comprises layered freeform skeleton parts 105 that will form the electric interconnections between the electric contacts of the interconnect structure after a conductive material 202 is applied on the backbone structure 100. The support structure 101 supports the layered freeform skeleton parts 105. Parts 306 of the support structure 10 may be removed to isolate and/or expose the electric interconnections 205. The cladding skeleton can be embedded by an insulating material 303 for providing a further support.

Interconnect structure and method for producing same

There is provided a three-dimensional interconnect structure for micro- electronic devices and a method for producing such an interconnect structure. The method comprises a step wherein a backbone structure 100 is manufactured using an additive layer-wise manufacturing process 310. The backbone structure 100 comprises a three-dimensional cladding skeleton 104 and a support structure 101. The cladding skeleton comprises layered freeform skeleton parts 105 that will form the electric interconnections between the electric contacts of the interconnect structure after a conductive material 202 is applied on the backbone structure 100. The support structure 101 supports the layered freeform skeleton parts 105. Parts 306 of the support structure 10 may be removed to isolate and/or expose the electric interconnections 205. The cladding skeleton can be embedded by an insulating material 303 for providing a further support.

Driver circuit for reducing the effects of disturbances on the duty cycle of a digital signal on a bus conductor

An electronic circuit contains a driver circuit (12) with an output coupled to a digital communication conductor (14), for driving changes of a potential at the digital communication conductor (14) to and from a digital signal level. The driver circuit (12) comprises a control circuit (120), to generate selection signals that select increasingly stronger drive strengths and increasingly weaker drive strengths during changes to and from the digital level respectively. A controllable current supply circuit (122, 124), has a current control input coupled to the control circuit (120) for receiving the selection signals and a current supply output coupled to the digital communication conductor (14). A detector circuit (126) has an input coupled to the digital communication conductor (14) and an output coupled to the control circuit (120), and arranged to detect whether a potential at the digital communication conductor (12) has reached a required range. The control circuit (120) stores information about the drive strength that was selected when the detector circuit (126) indicated that the range was reached during the change to the digital level, and during the change it restores the drive strength to the last stored drive strength as a first step during the change away from the digital level.

Distortionless amplifier

Pad for hot beverage and apparatus and method for manufacturing thereof

The invention relates to a pad for use in a beverage machine for preparing a warm beverage, a system therefor, and a method for manufacturing such pads. The pad comprises: - a first sheet having a surface area, wherein the surface area of the first sheet is provided with flow passages that are positioned at or near the outer perimeter of the first sheet; - a second sheet having a surface area, wherein the surface area of the second sheet is provided with one or more flow passages that are positioned at or near the centre of the second sheet; and wherein the first sheet and the second sheet are connected to each other at or near the outer perimeter for forming an inner space for holding the raw material that is usable for preparing the beverage, wherein substantially the entire surface area of the first and/or second sheet is impermeable to the flow of pressurized liquid, and wherein the impermeable surface area and the flow passages cooperate for forcing the flow of pressurized liquid to flow substantially in a direction that is parallel to the surface areas through the raw material in the pad.

Pad for hot beverage and apparatus and method for manufacturing thereof

The invention relates to a pad (2) for use in a beverage machine for preparing a warm beverage, a system therefor, and a method for manufacturing such pads. The pad comprises: - a first sheet (4) having a surface area, wherein the surface area of the first sheet is provided with flow passages (12) that are positioned at or near the outer perimeter of the first sheet; - a second sheet (6) having a surface area, wherein the surface area of the second sheet is provided with one or more flow passages (12) that are positioned at or near the centre of the second sheet; and wherein the first sheet and the second sheet are connected to each other at or near the outer perimeter for forming an inner space for holding the raw material that is usable for preparing the beverage, wherein substantially the entire surface area of the first and/or second sheet is impermeable to the flow of pressurized liquid, and wherein the impermeable surface area and the flow passages cooperate for forcing the flow of pressurized liquid to flow substantially in a direction that is parallel to the surface areas through the raw material in the pad.

Pad for hot beverage and apparatus and method for manufacturing thereof

The invention relates to a pad for use in a beverage machine for preparing a warm beverage, a system therefor, and a method for manufacturing such pads. The pad comprises: - a first sheet having a surface area, wherein the surface area of the first sheet is provided with flow passages that are positioned at or near the outer perimeter of the first sheet; - a second sheet having a surface area, wherein the surface area of the second sheet is provided with one or more flow passages that are positioned at or near the centre of the second sheet; and wherein the first sheet and the second sheet are connected to each other at or near the outer perimeter for forming an inner space for holding the raw material that is usable for preparing the beverage, wherein substantially the entire surface area of the first and/or second sheet is impermeable to the flow of pressurized liquid, and wherein the impermeable surface area and the flow passages cooperate for forcing the flow of pressurized liquid to flow substantially in a direction that is parallel to the surface areas through the raw material in the pad.

Gleichrichterentladungsröhre.

Treiberschaltung zur verringerung der effekte von störungen auf das tastverhältnis eines digitalsignals auf einem busleiter

Gepäcklaster

Method of converting power takeoff assembly to include selectively controlled multiple power takeoff shafts

A vehicle transmission assembly includes a power means, a clutch connected to the power means and having an output power shaft, and a plurality of gears and substantial alignment. The gears include a first gear on the power shaft meshed with a second gear mounted on a first idler shaft. The second gear driving a third gear mounted on another idler shaft. The third gear drives a fourth gear mounted on a first PTO shaft. A second PTO shaft is operatively connected to the first shaft. A three position selector assembly on the first shaft selectively powers the PTO shafts simultaneously or individually. The method of connecting a single PTO shaft transmission assembly includes adding a second PTO shaft to said power means, and imposing a multi-position selector assembly to the gears to permit said PTO shafts to be operated together or individually.

Production of fatty acids from a sieve fraction of activated sludge from treated wastewater

The invention is in the field of wastewater treatment, in particular to a method of producing fatty acids from a sieve fraction of waste water or activated sludge from treated wastewater, and is applicable to a filter fraction from any aqueous solution comprising biological and/or organic mate- rial. The invention further improves removal of P and/or N in a water treatment installation.