Substituted pyridinones as modulators of P38 MAP kinase.

Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compound and methods of treatment using the compounds are also disclosed.

ZYKLISCHE NEUROKININ A - ANTAGONISTEN

SUBSTITUTED PYRIDINONE AS MODULATORS FOR P38 MAP KINASE

LOOSE LEAF BINDER

Fresh cosmetic composition delivery system

A fresh composition delivery system includes a package with two compartments separated by a foil seal for separating a cosmetically acceptable carrier from an unstable active ingredient. An elastomeric bulb with a dart can be actuated by the user to pierce the foil seal so that the carrier and the active can be mixed in the package to form a composition shortly before use. For the resulting mixed composition, the level of the unstable active ingredient in the composition decreases by less than 6% over 7 days when stored at 25°C at 60% relative humidity.

Verfahren zur Schätzung einer Fahrzeuglast

Ein Verfahren zum Schätzen einer Last auf ein Fahrzeug (10), wobei das Verfahren umfasst: Erhalten eines ersten Lastschätzwertes unter Verwendung einer ersten Lastschätztechnik; Erhalten eines zweiten Lastschätzwertes unter Verwendung einer zweiten Lastschätztechnik; Analysieren von Eigenschaften des ersten Lastschätzwertes und des zweiten Lastschätzwertes; und, basierend auf der Analyse, Auswählen entweder des ersten Lastschätzwertes oder des zweiten Lastschätzwertes als einen Ausgangslastschätzwert.

Improvements in Self Lubricating Bearings for Guide Pullies and the like.

Real-time communication and information collaboration system

Cotton gin for pneumatic cotton harvesting machine

A cotton gin for use in a pneumatic cotton harvesting machine. The gin is located in the harvester downstream of the pneumatic picking heads. The gin receives seed bearing cotton balls on a front side of a fiber separation plate. Co-acting and oppositely rotating toothed fiber separation blades protrude through the separation plate and incrementally tear the cotton fiber free from the cotton ball leaving behind the seeds. The separated cotton fiber is, thereafter, drawn from the back or downstream side of the separation plate to a dust collector and then bailed in a dry condition in the harvester in the field. The separated seeds remain in the gin and fall downwardly, via gravity toward and into a seed collecting bin.

An Improved Churn.

... 6706. Thomas, O. March 19. Churns.-Fig. 2 shows a longitudinal vertical section of the churn, which consists of a body 4 having its ends semicircular or of the shape shown, and having a cover hinged at 18. The beaters 6, 6 are mounted on spindles driven at the same speed in opposite directions, as shown by the arrows. The beaters 6 are made easily removable, to facilitate cleaning. The beater spindles are formed with squared recesses at one end, which engage similar squared ends on the two driving-spindles, and with recesses at the other end into which bearing-pins can be inserted by the action of screws projecting through the sides of the churn.

SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE

Substituted Pyridinones as Modulators of p38 MAP Kinase

PNEUMATIC COTTON HARVESTING MACHINE

A cotton picking machine comprises a chassis for moving the machine in a traveling direction, a vacuum pump provided to create a predetermined vacuum and a cotton picking unit including a cotton picking head supported by the chassis. The cotton picking head includes upper and lower vacuum compartments both in fluid communication with the vacuum pump and connecting tubes vertically extending between the upper and lower vacuum compartments and movable along a predetermined endless path so as to be in sliding contact with the upper and lower vacuum compartments at the corresponding distal ends thereof. Each of the connecting tubes includes a set of hollow picking fingers radially outwardly extending therefrom. The predetermined endless path includes an extracting zone and an inoperative zone. The connecting tubes fluidly connect the upper and lower vacuum compartments only when the connecting tubes pass the extracting zone of the predetermined endless path.

Tool cutting element

The cutting element 1 includes a high pressure high temperature (HPHT) polycrystalline diamond (PCD) body 2 with a surface region 4. An electrically conductive wear sensor is formed at the surface region, the wear sensor comprising graphite. A method of making a turning or milling tool with the features described above includes forming the electrically conductive wear sensor with an electrical resistance substantially lower than that of the surface region. The wear sensor may have an electrically conductive track(s) 6, 7, and the track may define a tortuous path. The HPHT PCD body may have a non-conducting surface region. A non-conductive protective layer may be disposed over the conductive wear sensor. The wear sensor may be disposed on any of a rake face 4 and a clearance face 5. The cutting element may have a data track (10, Figure 3) for carrying an electrical signal between a data collection element 11 and the electrically conductive wear sensor. The method of making the cutting element ...

Pneumatic cotton harvesting machine

A cotton picking machine comprises a chassis for moving the machine in a traveling direction, a vacuum pump provided to create a predetermined vacuum and a cotton picking unit including a cotton picking head supported by the chassis. The cotton picking head includes upper and lower vacuum compartments both in fluid communication with the vacuum pump and connecting tubes vertically extending between the upper and lower vacuum compartments and movable along a predetermined endless path so as to be in sliding contact with the upper and lower vacuum compartments at the corresponding distal ends thereof. Each of the connecting tubes includes a set of hollow picking fingers radially outwardly extending therefrom. The predetermined endless path includes an extracting zone and an inoperative zone. The connecting tubes fluidly connect the upper and lower vacuum compartments only when the connecting tubes pass the extracting zone of the predetermined endless path.

FRESH COSMETIC COMPOSITION DELIVERY SYSTEM

A fresh composition delivery system includes a package with two compartments separated by a foil seal for separating a cosmetically acceptable carrier from an unstable active ingredient. An elastomeric bulb with a dart can be actuated by the user to pierce the foil seal so that the carrier and the active can be mixed in the package to form a composition shortly before use. For the resulting mixed composition, the level of the unstable active ingredient in the composition decreases by less than 6% over 7 days when stored at 25°C at 60% relative humidity.

Trousers Creaser.

... 22,312. Owen, T. Nov. 8. Trouser creasers; trouser stretchers. -Relates to an appliance for forming vertical creases in trouser legs. The trousers are folded in the ordinary way, the front edges are placed between two pieces A of wood, and the rear edges between two pieces B of wood. Each pair of pieces A and B is fastened together by screws and nuts C, and the two pairs are themselves joined together by crosspieces D, which have holes fitting over screws attached to the lower piece of each pair A and B and passed through holes in the upper piece. A number of holes are formed at one end of each piece D so that it can be adjusted in position as required. The Provisional Specification states that the appliance also serves to remove bagginess at the knees.

Substituted Pyridinones as Modulators of p38 MAP kinase

Fresh cosmetic composition delivery system

A fresh composition delivery system includes a package with two compartments separated by a foil seal for separating a cosmetically acceptable carrier from an unstable active ingredient. An elastomeric bulb with a dart can be actuated by the user to pierce the foil seal so that the carrier and the active can be mixed in the package to form a composition shortly before use. For the resulting mixed composition, the level of the unstable active ingredient in the composition decreases by less than 6% over 7 days when stored at 25°C at 60% relative humidity.

Improvements in Apparatus for Drying Tobacco Samples or the like.

... 13,026. Owen, T. July 19. Drying tobacco &c.-An appliance fur drying tobacco samples and the like is shown in Fig. 1. The material is placed in the drying-chamber 1, which is surrounded by a water jacket 2 and heated by a suitable burner 4. The gas supply to the burner is regulated by a slide valve 6 controlling the supply pipe 5 so as to maintain a uniform temperature of 212‹ F. in the chamber. The steam space of the water jacket is connected to the underside of a flexible diaphragm 11, which is connected to a lever 9 carrying an adjustable weight 13 and connected to the valve by a link 8. The chamber is provided with an internal rim 18 to catch condensed moisture. In a modification, a rotary plug valve actuated by a coiled flexible Bourdon tube may be used.

Diaryl substituted pyridinones

Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3/R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

VERFAHREN ZUR HERSTELLUNG EINER GRANULIERTEN WASCHMITTELZUSAMMENSETZUNG DIE EIN KRISTALLINES BUILDER-MATERIAL ENTHÄLT

A temporary barrier

Pneumatic cotton harvesting machine

Fresh cosmetic composition delivery system

A fresh composition delivery system includes a package with two compartments separated by a foil seal for separating a cosmetically acceptable carrier from an unstable active ingredient. An elastomeric bulb with a dart can be actuated by the user to pierce the foil seal so that the carrier and the active can be mixed in the package to form a composition shortly before use. For the resulting mixed composition, the level of the unstable active ingredient in the composition decreases by less than 6% over 7 days when stored at 25°C at 60% relative humidity.

SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE

Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R 2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed. © KIPO & WIPO 2007 ...

Pneumatic cotton harvesting machine

A cotton picking machine comprises a chassis for moving the machine in a traveling direction, a vacuum pump provided to create a predetermined vacuum and a cotton picking unit including a cotton picking head supported by the chassis. The cotton picking head includes upper and lower vacuum compartments both in fluid communication with the vacuum pump and connecting tubes vertically extending between the upper and lower vacuum compartments and movable along a predetermined endless path so as to be in sliding contact with the upper and lower vacuum compartments at the corresponding distal ends thereof. Each of the connecting tubes includes a set of hollow picking fingers radially outwardly extending therefrom. The predetermined endless path includes an extracting zone and an inoperative zone. The connecting tubes fluidly connect the upper and lower vacuum compartments only when the connecting tubes pass the extracting zone of the predetermined endless path.

SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE

VERFAHREN ZUR HERSTELLUNG EINER GRANULIERTEN WASCHMITTELZUSAMMENSETZUNG DIE EIN KRISTALLINES BUILDER-MATERIAL ENTHÄLT

SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE

Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein R, R, R, R, and R are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.12345 © KIPO & WIPO 2007 ...

SUBSTITUIERTE PYRIDINONE ALS MODULATOREN FÜR P38 MAP KINASE

ZYKLISCHE NEUROKININ A - ANTAGONISTEN

Fresh Cosmetic Composition Delivery System

A fresh composition delivery system includes a package with two compartments separated by a foil seal for separating a cosmetically acceptable carrier from an unstable active ingredient. An elastomeric bulb with a dart can be actuated by the user to pierce the foil seal so that the carrier and the active can be mixed in the package to form a composition shortly before use. For the resulting mixed composition, the level of the unstable active ingredient in the composition decreases by less than 6% over 7 days when stored at 25° C. at 60% relative humidity. 1. A fresh composition delivery system comprising: a first component including a dermatologically acceptable carrier; and', 'a second component including at least one unstable active ingredient; and, 'a composition comprising a tube having a dispensing spout with a cap at a first end and an open second end, a first portion of the tube adjacent the first end defining a reservoir, a quantity of the first component stored in the reservoir, and a second portion of the tube adjacent the second end having an inner surface of the open second end of the tube defining an inwardly directed sealing surface;', 'a cartridge having a tubular body dimensioned to fit closely in the second portion of the tube, the body having an outwardly directed sealing surface for engaging the inwardly directed sealing surface of the tube in airtight engagement, an inner end of the body positioned in the tube such the inner end opens toward the reservoir, an outer end of the body opposite the inner end, a foil inner seal closing the inner end, an actuator membrane located in the body between the inner end and the outer end, the actuator membrane forming a hermetic barrier between the inner end and the outer end of the body, a chamber defined in the body between the foil inner seal and the actuator membrane, a quantity of the second component stored in the chamber, a dart mounted on the actuator membrane such that it projects into the chamber ...

LEAD OR CONSUMER RELATIONSHIP DEVELOPMENT

An example method comprises monitoring actions of a user of an online service; detecting a triggering of an event; identifying information relevant to the event and associated with the user, the identifying being based at least in part on the monitored actions of the user; and generating an auto-message to the user providing the user with the information. 1. A method , comprising:detecting, by a server associated with an online service, a triggering of an event;identifying information relevant to the event and associated with a user of the online service; andgenerating, in response to triggering of the event, an auto-message to the user providing the user with the information, wherein the auto-message is personalized for the user of the online service.2. The method of claim 1 , further comprising:monitoring actions of the user on the online service,wherein the identifying information relevant to the event is based at least in part on the monitored actions of the user.3. The method of claim 1 , wherein the message is an automatically generated message based on the event.4. The method of claim 1 , wherein the event is triggered by the actions of the user.5. The method of claim 1 , wherein the event is triggered by an update of a database associated with the online service.6. The method of claim 5 , wherein the information relevant to the event and associated with the user is based on data in the database associated with the online service.7. The method of claim 1 , wherein the online service is a real-estate service.8. The method of claim 1 , further comprising:forwarding the auto-message to an agent associated with the user for approval.9. A computer program product claim 1 , embodied on a non-transitory computer readable medium claim 1 , comprising:computer code for detecting a triggering of an event;computer code for identifying information relevant to the event and associated with a user of an online service; andcomputer code for generating, in response to ...

Substituted pyridinones as modulators of p38 map kinase

Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

Substituted pyridinones as modulators of p38 map kinase

Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

Substituted pyridinones

Disclosed are compounds formula I, and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE

Jedinjenje formuleili njegove farmaceutski prihvatljive soli, gde:R5 je heteroaril ili heteroarilalkil, gde heteroaril i heteroaril grupe su po izboru supstituisane sa 1, 2, 3, ili 4 grupe koje su nezavisno -C(O)NR6R7,-(C1-C4 alkil)-C(O)NR6R7, -NR6R7, hidroksi(C1-C4)alkil, C1-C4 dihidroksialkil, H, OH, halogen, haloalkil, alkil, halpalkoksi, R6R7N-(C1-C6 alkil)-, -CO2-(C1-C6)alkil, -N(R)C(O)NR6R7, ili -N(R)C(O)-(C1-C6)alkoksi; ili R5 jeX1, je nezavisno odabran od -C(O)NR6R7, -(C1-C4 alkil)-C(O)NR6R7, - NR6R7, hidroksi(C1-C4)alkil, C1-C4 dihidroksialkil, OH, halogen, haloalkil, alkil, haloalkoksi, heteroaril, heterocikloalkil, C3-C7 cikloalkil, R6R7N-(C1-C6 alkil)-, -CO2-(C1-C6)alkil, -N(R)C(O)NR6R7, -N(R)C(O)-(C1-C6)alkoksi, CO2R-(C1-C6 alkil)-, ili - SO2NR6R7; gde su heteroaril i heterocikloalkil grupe po izboru supstituisane sa -NR6R7, -C(O)NR6R7, R6R7N-(C1-C6 alkil)-, C1-C6 alkil, C1-C6 alkoksi, ili halogenom;X2, Xa, Xb, Xc, Xd, i Xe su nezavisno odabrani od -C(O)NR6R7, -(C1-C4 alkil ...

PNEUMATIC COTTON HARVESTING MACHINE

A cotton picking machine comprises a chassis for moving the machine in a traveling direction, a vacuum pump provided to create a predetermined vacuum and a cotton picking unit including a cotton picking head supported by the chassis. The cotton picking head includes upper and lower vacuum compartments both in fluid communication with the vacuum pump and connecting tubes vertically extending between the upper and lower vacuum compartments and movable along a predetermined endless path so as to be in sliding contact with the upper and lower vacuum compartments at the corresponding distal ends thereof. Each of the connecting tubes includes a set of hollow picking fingers radially outwardly extending therefrom. The predetermined endless path includes an extracting zone and an inoperative zone. The connecting tubes fluidly connect the upper and lower vacuum compartments only when the connecting tubes pass the extracting zone of the predetermined endless path.

Pneumatic cotton harvesting machine

A cotton picking machine comprises a chassis for moving the machine in a traveling direction, a vacuum pump provided to create a predetermined vacuum and a cotton picking unit including a cotton picking head supported by the chassis. The cotton picking head includes upper and lower vacuum compartments both in fluid communication with the vacuum pump and connecting tubes vertically extending between the upper and lower vacuum compartments and movable along a predetermined endless path so as to be in sliding contact with the upper and lower vacuum compartments at the corresponding distal ends thereof. Each of the connecting tubes includes a set of hollow picking fingers radially outwardly extending therefrom. The predetermined endless path includes an extracting zone and an inoperative zone. The connecting tubes fluidly connect the upper and lower vacuum compartments only when the connecting tubes pass the extracting zone of the predetermined endless path.

Substituted pyridinones

Disclosed are compounds of Formula I and pharmaceutically acceptable salts thereof, wherein R₁, R₂, R₃, R₄, and R₅ are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

SUBSTITUTED PYRIDINONE AS MODULATOR OF P38 MAP KINASE

PROBLEM TO BE SOLVED: To provide a new compound useful as a modulator of a P38 MAP kinase. SOLUTION: The compound of the formula (wherein R1 is an alkyl which may arbitrarily be substituted, or the like; R2 is an arylalkoxy which may arbitrarily be substituted; R3 is H, a halogen, an alkoxycarbonyl which may be arbitrarily substituted, or the like; R4 is H or an alkyl which may arbitrarily be substituted; and R5 is an aryl which may arbitrarily be substituted, an arylalkyl or the like) and a pharmaceutically acceptable salt thereof are provided. COPYRIGHT: (C)2007,JPO&INPIT ...

CONTROL OF A VEHICLE HAVING AN AUTOMATIC TRANSMISSION TO COMPENSATE FOR AMBIENT AIR DENSITY

Control of a Vehicle Having an Automatic Transmission to Compensate for Ambient Air Density A method of controlling an automatic transmission () of a vehicle (), the method comprising: receiving a signal indicative of a vehicle operating mode; obtaining a base map defining gear shift points for the transmission () based on the indicated vehicle operating mode; obtaining a torque loss map defining gear shift points for the transmission () based on a predetermined minimum value of density; and controlling the transmission () based on the base map if the base map defines gear shift points at higher engine speeds or vehicle speeds than the corresponding gear shift points defined by the torque loss map. 117-. (canceled)18. A method of controlling an automatic transmission of a vehicle , the method comprising:receiving a signal indicative of a vehicle operating mode;obtaining a base map defining gear shift points for the transmission based on the indicated vehicle operating mode;obtaining a torque loss map defining gear shift points for the transmission based on a predetermined minimum value of air density;controlling the transmission based on the base map if the base map defines gear shift points at higher engine speeds or vehicle speeds than the corresponding gear shift points defined by the torque loss map; andobtaining a signal indicative of a gradient of a surface on which the vehicle is positioned by estimating a gradient of a surface on which the vehicle is positioned, or receiving a signal indicative of a gradient of a surface on which the vehicle is positioned.19. The method of claim 18 , comprising receiving one or more signals indicative of ambient air density and obtaining a compensated map defining gear shift points for the transmission based on the or each signal indicative of ambient air density.20. The method of claim 19 , wherein obtaining the compensated map comprises interpolating between the torque loss map and the base map in accordance with the or ...

Diaryl Substituted Pyridinones

Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R₁, R₂, R₃, R₄, and R₅ are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

Substituted pyridinones

Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R₁, R₂, R₃, R₄, and R₅ are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

COTTON GIN FOR PNEUMATIC COTTON HARVESTING MACHINE

A cotton gin for use in a pneumatic cotton harvesting machine. The gin is located in the harvester downstream of the pneumatic picking heads. The gin receives seed bearing cotton balls on a front side of a fiber separation plate. Co-acting and oppositely rotating toothed fiber separation blades protrude through the separation plate and incrementally tear the cotton fiber free from the cotton ball leaving behind the seeds. The separated cotton fiber is, thereafter, drawn from the back or downstream side of the separation plate to a dust collector and then bailed in a dry condition in the harvester in the field. The separated seeds remain in the gin and fall downwardly, via gravity toward and into a seed collecting bin. 1. A cotton gin for a pneumatic cotton harvesting machine , comprising:a frame having two opposed sides;a fiber separation plate suspended between said opposed sides having an upwardly oriented front side and a downwardly oriented back side and including slots therein,at least one pair of oppositely rotating toothed blades partially protruding through said slots towards said front side from said back side of said plate,a pair of shafts respectively supported by said frame and supporting said toothed blades for rotation in a partially overlapping edge to edge relation, wherein,seeded cotton balls come into contact with said front side of said plate and are supported thereby as said oppositely rotating toothed blades snatch and separate cotton fiber from said seeded cottons balls, and pass said cotton fiber to said back side of the fiber separation plate through said slots.2. A cotton gin as in claim 1 , wherein:multiple pairs of rotating toothed blades are suspended along, in parallel arrangement, said pair of shafts co-acting with a single fiber separation plate.3. A cotton gin as in claim 1 , wherein:multiple pairs of shafts with multiple pairs of rotating co-acting toothed blades are suspended between said opposed sides of said frame in a single ...

Real-time communication and information collaboration system

A method and apparatus for real-time communication and collaboration including visual modelling and creation of virtual collaboration regions in which users come together and see the media other users have to decide how they will communicate via use of compatible communication devices or common or connected software platforms.

Method and Apparatus for Selective Seismic Detection of Elongated Targets

A seismic wave source and sensing system coupled to the surface of an elastic wave propagation medium has a seismic wave source transducer having a preferred axis of vibration oriented horizontally on the surface of the elastic wave propagation medium. A seismic wave sensing transducer has a preferred axis of vibration response oriented horizontally on the surface of said elastic wave propagation medium such that said sensing transducer is capable of detecting dynamic particle motions and displacements of SH waves. An arrangement of the source and sensing transducers is provided on the surface of the elastic wave propagation medium. A recording system capable of acquiring and storing reflected SH wave signals detected by the sensing transducer, wherein the recorded signals represent reflections from contrasting physical properties within the elastic wave propagation medium to provide preferential detection of elongate subsurface targets such as utility pipes, conduits, and other similar object. 1. A seismic wave source and sensing system coupled to the surface of an elastic wave propagation medium comprising:a seismic wave source transducer having a preferred axis of vibration oriented horizontally on the surface of said elastic wave propagation medium such that said source transducer is thereby capable of generating horizontal shear stresses in said medium which in turn cause dynamic particle motions and displacements in said medium that radiate as horizontally polarized shear waves, commonly referred to as SH waves, into said medium, said radiated SH waves propagating in a direction perpendicular to said shear stresses and displacements produced by said source transducer, said SH wave propagation being in the radial direction about the preferred axis of vibration of said source transducer including SH waves propagating in a downgoing direction into said elastic wave propagation medium;a seismic wave sensing transducer having a preferred axis of vibration response ...

INTERACTIVE SYSTEM AND METHOD OF MODIFYING USER INTERACTION THEREIN

Interactive blocks () that present changeable individual characterizations () and sensory output based on meaningful assemblage of sensed individual characterizations from similar juxtaposed blocks () are configured to record their interactions to produce an historic log or both successful interactions that yield a sensory output or failed interactions that produce no logical or meaningful sensory event. Uploading of the historical log () permits automated computational assessment of all interactions, with a centralized computing resource dynamically arranged to cause selective download of new content and/or new operating instructions to one or more of the interactive blocks () based of identification of trends in the historical record. The new content and operating instructions modifies operation of cooperating blocks to produce different, processor controlled individual characterizations an/or sensory outputs that reinforce learning or identified mistakes arising from inappropriate manipulation of the interactive blocks. The interactive blocks () can be realized as physical entities or otherwise in a virtual screen environment, with the sensory output being visual, audible and/or a haptic response. 1. A manually manipulable device comprising:a processor arranged to control operation of the device;a power source providing power to the device;a visual display unit arranged to display visual display material;a response generator for generating a sensory response;a communications unit configured, in use, to effect communication with a similar manually manipulable device; andwherein the device is configured to present a changeable individual characterization represented by display of visual display material and wherein the processor generates a sensory response in its response generator or a sensory response in a response generator of a similar device, the generated sensory response dependent upon at least one of the individual characterization presented by the device ...

MOUNTABLE CABLE TIE WITH FINE ADJUSTMENT AND METHOD OF USE THEREOF

A mountable cable tie with fine adjustment with an elongated strap having a first strap end and a second strap end, the elongated strap having one or more rows of teeth or cross-bars formed crosswise on the elongated strap, and a plurality of holes positioned linear along the median between the one or more rows of teeth, at least one locking buckle positioned proximate the second strap end, the at least one locking buckle having at least one channel and at least one locking tang or pawl positioned within the locking buckle, wherein increased insertion of the first strap end into the locking head decreases the size of the loop of the elongated strap to secure the bundle. 1. A cable tie , to affix one or more elongated members to an object , the cable tie comprising:a strap configured with a first strap end and a second strap end, said strap configured with a plurality of cross-bars extended along said strap, said plurality of cross-bars configured in two or more rows, said strap configured with one or more longitudinally spaced apertures therethrough, wherein said apertures are positioned proximate said plurality of cross-bars;a locking buckle positioned proximate said second strap end, said locking buckle configured with a channel therethrough, said channel configured with one or more pawls positioned side-by-side therein to confront individually associated ones of said plurality of cross-bars of said strap.2. The cable tie of claim 1 , said strap further comprising one or more rails configured to run from approximately said first strap end to said second strap end.3. The cable tie of claim 2 , wherein said one or more rails and said channel is configured to accommodate passage therethrough of said strap.4. The cable tie of claim 1 , wherein said plurality of cross-bars are positioned crosswise on said strap.5. The cable tie of claim 1 , wherein said plurality of cross-bars are positioned parallel to one another on said strap.6. The cable tie of claim 1 , wherein ...

Eye-Mounted Displays Including Embedded Conductive Coils

An augmented reality system can include an electronic contact lens and a power source. The source generates a time-varying magnetic field which induces a time-varying current in conductive coils embedded in the electronic contact lens. The electronic contact lens uses the induced current to harvest power or to determine the orientation of the contact lens. The embedded conductive coils are positioned such that the AR system can harvest power and estimate the orientation of the eye at a variety of contact lens orientations. The conductive coils may be embedded within the contact lens at any number of positions and orientations. The embedded coils can encircle a portion of the contact lens and can collectively form an annulus within the contact lens. The conductive coils are embedded such that for at least three conductive coils, no two of the planes defined by the at least three conductive coils are parallel. 1. A contact lens comprising:three conductive coils coupled to or embedded within the content lens, each conductive coil for generating an electrical signal from a time-varying electromagnetic field, each conductive coil defining a corresponding plane such that no two corresponding planes are parallel.2. The contact lens of claim 1 , further comprising:an energy harvesting circuit coupled to the three conductive coils for converting the electrical signals generated by the three conductive coils into power.3. The contact lens of claim 2 , wherein the amount of power produced by the energy circuit from a conductive coil is based on the orientation of the corresponding plane defined by the conductive coil relative to a direction of the time-varying electromagnetic field.4. The contact lens of claim 1 , further comprising:a orientation sensing circuit coupled to the three conductive coils for determining an orientation of the contact lens based on the electrical signals generated by the three conductive coils.5. The contact lens of claim 1 , wherein a perimeter of a ...

COMPOSITE PROTON CONDUCTING ELECTROLYTE WITH IMPROVED ADDITIVES FOR FUEL CELLS

Improved additives can be used to prepare polymer electrolyte for membrane electrode assemblies in polymer electrolyte fuel cells. Use of these improved additives can not only improve durability and performance, but can also provide a marked performance improvement during initial conditioning of the fuel cells. The additives are chemical complexes comprising certain metal and organic ligand components. 1. A proton conducting composite polymer electrolyte for a membrane electrode assembly in a solid polymer electrolyte fuel cell comprising a proton conducting ionomer and an amount of a (1ligand)(metal) complex additive wherein:the (metal) in the complex is selected from the group consisting of metals, metal alloys, metal oxides, metal salts and combinations thereof;{'sup': 'st', 'the (1ligand) in the complex comprises a molecule or polymer bearing the metal chelating moieties of the molecule wherein the chemical structure of the molecule is a derivative of the heterocycle quinoline.'}2. The composite polymer electrolyte of wherein the (metal) is Ce or Mn.6. The composite polymer electrolyte of wherein the (metal) is Ce or Mn.7. The composite polymer electrolyte of wherein the (2ligand) is bathophenanthroline.9. A membrane electrode assembly for a solid polymer electrolyte fuel cell comprising an anode catalyst layer claim 1 , a membrane electrolyte claim 1 , a cathode catalyst layer and the composite polymer electrolyte of .10. The membrane electrode assembly of wherein the membrane electrolyte comprises the composite polymer electrolyte of .11. A solid polymer electrolyte fuel cell comprising the membrane electrode assembly of .12. A method of making the composite polymer electrolyte of comprising:preparing an amount of (metal) from a precursor for the (metal);{'sup': 'st', 'preparing an amount of (1ligand);'}{'sup': 'st', 'mixing the amount of (metal) and the amount of (1ligand) in a solution or dispersion comprising the proton conducting ionomer thereby preparing ...

Gamified Alphanumeric Character Identification

A method includes receiving from a first detection system, an image of a license plate, applying an optical recognition function to characters of the license plate, and assigning a confidence value to each of the characters. The method further includes, in response to determining that the confidence value for a particular character is below a threshold, sending an image of the character to a gamified human reviewer application, receiving from the gamified human reviewer application, a human response indicative of a characteristic of the character, and updating the optical recognition function based on the characteristic of the character. 1. A method performed by a computing system , the method comprising:receiving from a first detection system, an image of a license plate;applying an optical recognition function to characters of the license plate;assigning a confidence value to each of the characters;in response to determining that the confidence value for a particular character is below a threshold, sending an image of the character to a gamified human reviewer application;receiving from the gamified human reviewer application, a human response indicative of a characteristic of the character; andupdating the optical recognition function based on the characteristic of the character.2. The method of claim 1 , wherein the characteristic comprises the character being too dark.3. The method of claim 1 , wherein the characteristic comprises the character being too light.4. The method of claim 1 , wherein the characteristic comprises the character being too blurry.5. The method of claim 1 , wherein the image of the character is obstructs other characters of the license plate.6. The method of claim 1 , further comprising claim 1 , with the gamified human reviewer application claim 1 , presenting the character within a personalized graphical user interface.7. The method of claim 6 , further comprising claim 6 , displaying to a user through the graphical user interface claim ...

LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS

Disclosed herein are compounds of formula (I) 3. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein:{'sup': '2', 'Lis a bond;'}{'sup': 4', '2', '3, 'Lis —C(R)═C(R)—;'}{'sup': 2', '3, 'Rand Rare each hydrogen;'}{'sup': 4', '5, 'sub': 1', '4, 'Rand Rare independently H or C-Calkyl;'}{'sup': '3', 'sub': 2', '6', '2', '6, 'Lis C-Calkynylene; wherein the C-Calkynylene is optionally substituted with 1, 2, 3, or 4 fluoro substituents; and'}{'sup': '6', 'sub': 1', '10', '1', '4', '1', '3', '1', '3', '1', '3', '1', '3', '1', '3, 'Ris aryl or C-Calkyl, wherein the aryl is optionally substituted with 1, 2, 3, or 4 substituents selected from the group consisting of C-Calkyl, C-Chaloalkyl, cyano, halogen, C-Calkoxy, C-Chaloalkoxy; and —C-Calkylene-C-Calkoxy.'}8. The compound of claim 5 , or a pharmaceutically acceptable salt thereof claim 5 , wherein:{'sup': '3', 'sub': '2', 'Lis —CH—C≡C—; and'}s is 1.9. The compound of claim 5 , or a pharmaceutically acceptable salt thereof claim 5 , wherein:{'sup': '3', 'Lis —C≡C—; and'}s is 0.10. The compound of claim 5 , or a pharmaceutically acceptable salt thereof claim 5 , wherein:{'sup': '1', 'sub': 3', '7', '3', '7, 'Lis C-Calkylene, wherein the C-Calkylene is optionally substituted with 1, 2, 3, or 4 fluoro substituents.'}12. The compound of claim 8 , or a pharmaceutically acceptable salt thereof claim 8 , wherein:{'sup': '1', 'sub': 3', '7', '3', '7, 'Lis C-Calkylene, wherein the C-Calkylene is optionally substituted with 1, 2, 3, or 4 fluoro substituents.'}14. The compound of claim 9 , or a pharmaceutically acceptable salt thereof claim 9 , wherein:{'sup': '1', 'sub': 3', '7', '3', '7, 'Lis C-Calkylene, wherein the C-Calkylene is optionally substituted with 1, 2, 3, or 4 fluoro substituents.'}16. The compound of claim 7 , or a pharmaceutically acceptable salt thereof claim 7 , wherein:{'sup': '3', 'sub': '2', 'Lis —CH—C≡C—; and'}s is 1.17. The compound of claim 7 , or a pharmaceutically ...

ANION-CONDUCTING POLYMER

Disclosed herein are anion-conducting polymers that comprise a cationic benzimidazolium and imidazolium moieties. Methods of forming the polymers and membranes comprising the polymers are also provided. 2. The polymer of claim 1 , wherein the polymer is a salt formed with an anion selected from the group consisting of iodide claim 1 , hydroxide claim 1 , chloride claim 1 , bromide claim 1 , fluoride claim 1 , cyanide claim 1 , acetate claim 1 , carbonate claim 1 , nitrate claim 1 , sulfate claim 1 , phosphate claim 1 , triflate claim 1 , and tosylate.3. The polymer of claim 1 , wherein the benzimidazolium-containing moiety is included in a main chain of the polymer.4. The polymer of claim 1 , wherein the benzimidazolium-containing moiety is included in a pendant group of the polymer.5. The polymer of claim 1 , wherein the benzimidazolium-containing moiety is part of a crosslink of the polymer.6. An ionic membrane comprising a cationic polymer of .7. The ionic membrane of claim 6 , further comprising an anionic polymer.8. The ionic membrane of claim 7 , wherein the cationic polymer is conically bound to the anionic polymer.9. The ionic membrane of claim 6 , further comprising an acidic polymer.10. The ionic membrane of claim 9 , wherein the acidic polymer comprises a benzimidazole-containing moiety.11. The ionic membrane of claim 9 , wherein the cationic polymer is bound to an anionic polymer created in situ after the deprotonation of the acidic polymer.13. An ionic membrane containing the polymer of .15. The polymer of claim 14 , wherein the polymer is a salt formed with an anion selected from the group consisting of iodide claim 14 , hydroxide claim 14 , chloride claim 14 , bromide claim 14 , fluoride claim 14 , cyanide claim 14 , acetate claim 14 , carbonate claim 14 , nitrate claim 14 , sulfate claim 14 , phosphate claim 14 , triflate claim 14 , and tosylate.16. The polymer of claim 14 , wherein the imidazolium-containing moiety is included in a pendant group of ...

Patient Monitoring System and Apparatus

Apparatus includes a mat having a surface which contacts with a support means and opposing surface located with respect to a part of a person so that at least one parameter of the person is monitored by sensor means with the mat. The sensor means are connected with processing means to allow data relating to the at least one parameter to be collected and processed to generate a value which is indicative of the parameter at the time of the data collection and hence an indication of the condition of the person. The mat includes a plurality of spaced apart sensor means locations to provide an accurate collection of data for different parts and zones relating to the patient on a real time basis and make this available to care givers for the person. 1. Apparatus for monitoring of a condition of a person , said apparatus comprising:a provision of a mat having a surface which contacts with a support means and an opposing surface located with respect to at least part of the person so that at least one parameter of the person is monitored by a plurality of sensor means provided at locations with the mat and said plurality of sensor means are connected with processing means in order to allow data relating to the said at least one parameter to be collected and processed to generate a value which is indicative of the said parameter at a time of the data collection and wherein said mat includes a plurality of spaced apart sensor means locations.2. Apparatus according to wherein data from the plurality of sensor means locations is combined and processed in order to generate a value for the said at least one parameter.3. Apparatus according to wherein the apparatus includes a plurality of different types of sensor means to allow data for different parameters of the patient to be provided and processed to generate values for said different parameters and/or a value representative of the persons condition as defined by the plurality of said parameter values.4. Apparatus according to ...

Foundation Makeup And Concealer Composition

A unitary packaged color cosmetic composition having a foundation makeup benefit and a concealer benefit, said composition stored in a receptacle having a closure and applicator, wherein the applicator has a foundation makeup benefit application section and a concealer benefit application section and the section of the applicator used to apply the composition to the keratin surface application area corresponds to the desired benefit. 2. The method of wherein the concealer benefit section of the applicator has one or more subsections and the foundation makeup benefit section of the applicator has at least two subsections.3. The method of wherein the foundation makeup benefit section of the applicator has a subsection for applying the composition to large areas of the face and a subsection for applying the composition to smaller areas of the face to achieve the foundation makeup benefit.4. The method of wherein the concealer benefit section of the applicator has a subsection for applying the composition to discrete sections of the face to achieve the concealer benefit.5. The method of wherein one subsection of the foundation makeup benefit section of the applicator has an application surface that is angled from 40 to 60 degrees.6. The method of wherein the application surface that is angled from 40 to 60 degrees has a concave surface forming a reservoir for holding the composition.7. The composition of wherein the application surface is angled about 45° and has a surface area of about 0.2 to 0.7 inches.8. The method of wherein the applicator is made of a compressible sponge or flock.9. The method of wherein concealer benefit is applied to the face around the eyes or on discrete areas of the keratin surface application area where concealment of specific skin flaws is desired.10. The method of wherein the foundation makeup benefit is applied to the face where the application area that is the forehead claim 3 , nose claim 3 , chin claim 3 , and cheeks.11. The method of ...

TITANIUM ALLOY WITH MODERATE STRENGTH AND HIGH DUCTILITY

A titanium alloy composition is provided. In weight percent (wt. %), the alloy includes 5.7 to 8.0% vanadium, 0.5 to 1.75% aluminum, 0.25 to 1.5% iron, 0.1 to 0.2% oxygen, up to 0.15% silicon, up to 0.1% carbon and less than 0.03% nitrogen is provided. In one form, the titanium alloy has a 0.2% yield strength between 600 to 850 MPa, an ultimate tensile strength between 700 to 950 MPa, a percent elongation to failure between 20 to 30%, a percent reduction in area between 40 to 80%, a Charpy U-notch impact energy between 30 to 70 J, and/or a Charpy V-notch impact energy between 40 to 150 J. 1. A titanium alloy comprising (in wt. %) 5.7 to 8% vanadium; 0.5 to 1.75% aluminum; 0.25 to 1.5% iron; 0.1 to 0.2% oxygen; up to 0.15% silicon; up to 0.1% carbon and less than 0.03% nitrogen.2. The titanium alloy according to claim 1 , wherein vanadium is between 5.9 to 8%.3. The titanium alloy according to claim 1 , wherein vanadium is between 6.1 and 8%.4. The titanium alloy according to claim 1 , wherein the vanadium is between 6.8 to 7.8%; aluminum is between 0.9 to 1.5%; iron is between 0.5 to 1.1%; oxygen is between 0.12 to 0.19%; and silicon is up to 0.12%.5. The titanium alloy according to claim 1 , wherein vanadium is 7.3%; aluminum is 1.2%; iron is 0.8%; silicon is 0.05%; and oxygen is 0.16%.6. The titanium alloy according to comprising 7.2% vanadium; 1.2% aluminum; 0.8% iron; 0.15% oxygen; 0.05% silicon; and carbon and nitrogen are reduced to impurities.7. The titanium alloy according to claim 1 , wherein the titanium alloy further comprises:a 0.2% yield strength between 600 to 850 MPa, an ultimate tensile strength between 700 to 950 MPa, a percent elongation to failure between 20 to 30%, a percent reduction in area between 40 to 80%; andat least one of a Charpy U-notch impact energy between 30 to 70 J and a Charpy V-notch impact energy between 40 to 150 J.8. The titanium alloy according to claim 1 , wherein the titanium alloy further comprises:a 0.2% yield strength ...

PUSH PIN WITH ANTIROTATIONAL STOPPER AND METHOD OF USE THEREOF

A push pin with rotational stopper and method of use thereof includes a push pin configured with a plurality of retention barbs extending outward from a surface of the insertion member, the insertion member configured with an anti-rotation section to friction fit therewith a sidewall of an aperture in the panel, an disc spring positioned proximate said anti-rotation section and configured to provide an opposing force to said retention barbs to limit insertion and removal therein the aperture in the panel. 1. A push pin for insertion into an aperture in a panel , said push pin comprising:an elongated member, said elongated member having a first member end and a second member end configured with one or more retention barbs extending outward from said elongated member and positioned therebetween said first member end and said second member end;an anti-rotation section positioned proximate and integral thereto said first member end, said anti-rotation section configuration is selected from the group consisting of a star, an ‘H’, a triangle, a pentagon, a hexagon, a heptagon, an octagon, a nonagon, a decagon, a cross, a square, a rectangle, a rhombus, a trapezoid, a parallelogram, and a plus; anda disc spring positioned proximate and integral thereto said three or more sided anti-rotation section opposite said elongated member.2. The push pin of claim 1 , wherein said one or more retention barbs configured on an acute angle relative to said elongated member from said second member end to said first member end.3. The push pin of claim 2 , wherein said disc spring configured on an obtuse angle relative to said elongated member from said second member end to said first member end.4. The push pin of claim 3 , wherein said one or more retention barbs provides a counter removal force and said disc spring provides a counter insertion force to hold the push pin therein the aperture in the panel.5. The push pin of claim 4 , wherein said counter removal force opposes said counter ...

RELEASEE CASH-RELEASE TOOL AND METHODS OF USE

Disclosed is cash-release system and methods of use for releasing a cash balance of an account associated with a releasee from a secure facility. One embodiment includes a ticket/card printer/dispenser and a cash-release station operating at the secure facility and a network operations center operating remotely to the secure facility. The network operations center may include an operations processor that is coupled with the ticket dispenser and the cash-release station via a secure communications network, wherein the operations processor implements a cash-release management module to retrieve identity information for and the account balance of the releasee from an accounts-management and records system associated with the secure facility, to dispense an encoded ticket/card providing or linking to the identity information and the account balance, and to operate a cash-release station to read the encoded ticket, verify the identity information, and dispense the account balance to the releasee. Other embodiments are disclosed. 1. A system for managing a cash-release transaction for a releasee from a secure facility , the system comprising:a ticket dispenser operating at the secure facility, the ticket dispenser in communication with a secure communications network;a cash-release station operating at the secure facility, the cash-release station in communication with the secure communications network; and retrieving, from an accounts-management and records system associated with the secure facility, stored identity information and a balance of an account associated with the releasee;', 'dispensing an encoded ticket from the ticket dispenser, the encoded ticket having a code associated with the stored identity information and the balance of the account; and', reading the code on the encoded ticket;', 'verifying that an identity input from the releasee matches the stored identity information associated with the releasee; and', 'dispensing a cash amount equal to the ...

DIFLUOROLACTAM COMPOSITIONS FOR EP4-MEDIATED OSTEO RELATED DISEASES AND CONDITIONS

Disclosed herein are compositions and methods of treating osteroporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) 6. The method of claim 5 , wherein:{'sup': 4', '5, 'sub': '3', 'Rand Rare independently H or CH;'}{'sup': 6', '3', '7, 'sub': 3', '10', '3', '10, 'Ris C-Calkyl, C-Calkynyl, or L-R;'}{'sup': '3', 'sub': 1', '6', '2', '6', '1', '6', '2', '6, 'Lis C-Calkylene or C-Calkynylene; wherein the C-Calkylene and C-Calkynylene are optionally substituted with 1, 2, 3, or 4 fluoro substituents; and'}{'sup': 7', '7, 'sub': 1', '4', '1', '3', '1', '3', '1', '3', '1', '3', '1', '3, 'Ris aryl, wherein Ris optionally substituted with 1, 2, 3, or 4 substituents selected from the group consisting of C-Calkyl, C-Chaloalkyl, cyano, halogen, C-Calkoxy, C-Chaloalkoxy, and —C-Calkylene-C-Calkoxy.'}9. The method of claim 5 , wherein:{'sup': '6', 'sub': 3', '10', '3', '10', '3', '10', '3', '10', '3', '10', '3', '10, 'Ris C-Calkyl, C-Calkenyl, C-Calkynyl, C-Chaloalkyl, C-Chaloalkenyl, or C-Chaloalkynyl.'}10. The method of claim 5 , wherein:{'sup': 6', '3', '7, 'Ris L-R;'}{'sup': '3', 'sub': 1', '6', '2', '6', '2', '6', '1', '6', '2', '6', '2', '6, 'Lis C-Calkylene, C-Calkenylene, or C-Calkynylene; wherein the C-Calkylene, C-Calkenylene, and C-Calkynylene are optionally substituted with 1, 2, 3, or 4 fluoro substituents; and'}{'sup': 7', '7, 'sub': 1', '4', '1', '3', '1', '3', '1', '3', '1', '3', '1', '3, 'Ris aryl, wherein Ris optionally substituted with 1, 2, 3, or 4 substituents selected from the group consisting of C-Calkyl, C-Chaloalkyl, cyano, halogen, C-Calkoxy, C-Chaloalkoxy, and —C-Calkylene-C-Calkoxy.'}11. The method of claim 5 , wherein:{'sup': '1', 'sub': 3', '7', '3', '7, 'Lis C-Calkylene, wherein the C-Calkylene is optionally substituted with 1, 2, 3, or 4 fluoro substituents.'}13. The method of claim 9 , wherein:{'sup': '1', 'sub': 3', '7', '3', '7, 'Lis C-Calkylene, wherein the C-Calkylene is optionally ...

MOUNTABLE CABLE TIE WITH FINE ADJUSTMENT AND METHOD OF USE THEREOF

A mountable cable tie with fine adjustment with an elongated strap having a first strap end and a second strap end, the elongated strap having one or more rows of teeth or cross-bars formed crosswise on the elongated strap, and a plurality of holes positioned linear along the median between the one or more rows of teeth, at least one locking buckle positioned proximate the second strap end, the at least one locking buckle having at least one channel and at least one locking tang or pawl positioned within the locking buckle, wherein increased insertion of the first strap end into the locking head decreases the size of the loop of the elongated strap to secure the bundle. 1. A cable tie , to affix one or more elongated members to an object , the cable tie comprising:a strap configured with a first strap end and a second strap end and a top side and an underside, said strap configured with a plurality of cross-bars extended in two parallel spaced rows along each of said top side and said underside of said strap, said strap configured with one or more longitudinally spaced apertures therethrough, wherein said apertures are positioned between said two parallel rows of said plurality of cross-bars;a locking buckle positioned proximate said second strap end, said locking buckle is further configured to be approximately perpendicular to said second strap end, said locking buckle configured with a channel therethrough, wherein said channel is formed approximately parallel to said second strap end, said channel configured with two stationary pawls positioned therein to confront individually associated pairs of said plurality of cross-bars extended in two parallel spaced rows along said top side of said strap; anda tongue hingedly extended from said second strap end, said tongue configured with two ratchetable pawls facing said channel and opposing said stationary pawls, said two ratchetable pawls to confront individually associated pairs of said plurality of cross-bars ...

NETWORK-ACCESSIBLE MACHINE LEARNING MODEL TRAINING AND HOSTING SYSTEM

A network-accessible machine learning service is provided herein. For example, the network-accessible machine learning service provider can operate one or more physical computing devices accessible to user devices via a network. These physical computing device(s) can host virtual machine instances that are configured to train machine learning models using training data referenced by a user device. These physical computing device(s) can further host virtual machine instances that are configured to execute trained machine learning models in response to user-provided inputs, generating outputs that are stored and/or transmitted to user devices via the network. 1. A system comprising:a training model data store; and obtain, from a user device, a training request, wherein the training request comprises an indicator of a container image, an indicator of training data, and one or more first hyperparameter values;', 'initialize a machine learning (ML) training container in the first virtual machine instance, wherein the ML training container is formed from the container image;', 'cause the first virtual machine instance to execute code stored within the ML training container according to the one or more first hyperparameter values, wherein execution of the code causes the first virtual machine instance to train a machine learning model using the training data and to generate model data that represents characteristics of the machine learning model; and', 'store the model data in the training model data store., 'a first computing device to host a first virtual machine instance, the first computing device comprising computer-executable instructions that, when executed, cause the first computing device to2. The system of claim 1 , wherein the computer-executable instructions claim 1 , when executed claim 1 , further cause the first computing device to:obtain a modification request to modify the machine learning model being trained, wherein the modification request comprises an ...

DIFLUOROLACTAM COMPOSITIONS FOR EP4-MEDIATED OSTEO RELATED DISEASES AND CONDITIONS

Disclosed herein are compositions and methods of treating osteoporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) 6. The method of claim 5 , wherein:{'sup': 4', '5, 'sub': '3', 'Rand Rare independently H or CH;'}{'sup': 6', '3', '7, 'sub': 3', '10', '3', '10, 'Ris C-Calkyl, C-Calkynyl, or L-R;'}{'sup': '3', 'sub': 1', '6', '2', '6', '1', '6', '2', '6, 'Lis C-Calkylene or C-Calkynylene; wherein the C-Calkylene and C-Calkynylene are optionally substituted with 1, 2, 3, or 4 fluoro substituents; and'}{'sup': 7', '7, 'sub': 1', '4', '1', '3', '1', '3', '1', '3', '1', '3', '1', '3, 'Ris aryl, wherein Ris optionally substituted with 1, 2, 3, or 4 substituents selected from the group consisting of C-Calkyl, C-Chaloalkyl, cyano, halogen, C-Calkoxy, C-Chaloalkoxy, and —C-Calkylene-C-Calkoxy.'}9. The method of claim 5 , wherein:{'sup': '6', 'sub': 3', '10', '3', '10', '3', '10', '3', '10', '3', '10', '3', '10, 'Ris C-Calkyl, C-Calkenyl, C-Calkynyl, C-Chaloalkyl, C-Chaloalkenyl, or C-Chaloalkynyl.'}10. The method of claim 5 , wherein:{'sup': 6', '3', '7, 'Ris L-R;'}{'sup': '3', 'sub': 1', '6', '2', '6', '2', '6', '1', '6', '2', '6', '2', '6, 'Lis C-Calkylene, C-Calkenylene, or C-Calkynylene; wherein the C-Calkylene, C-Calkenylene, and C-Calkynylene are optionally substituted with 1, 2, 3, or 4 fluoro substituents; and'}{'sup': 7', '7, 'sub': 1', '4', '1', '3', '1', '3', '1', '3', '1', '3', '1', '3, 'Ris aryl, wherein Ris optionally substituted with 1, 2, 3, or 4 substituents selected from the group consisting of C-Calkyl, C-Chaloalkyl, cyano, halogen, C-Calkoxy, C-Chaloalkoxy, and —C-Calkylene-C-Calkoxy.'}11. The method of claim 5 , wherein:{'sup': '1', 'sub': 3', '7', '3', '7, 'Lis C-Calkylene, wherein the C-Calkylene is optionally substituted with 1, 2, 3, or 4 fluoro substituents.'}13. The method of claim 9 , wherein:{'sup': '1', 'sub': 3', '7', '3', '7, 'Lis C-Calkylene, wherein the C-Calkylene is optionally ...

CERAMIC MATRIX COMPOSITE COMPONENT FORMING METHOD

A method of forming a ceramic matrix composite component is provided. The method includes the steps of: providing a pattern element; coating the pattern element with a ceramic slurry; drying the slurry to form a ceramic layer; forming a ceramic matrix composite body on a surface of the ceramic layer to produce a ceramic matrix composite component with the ceramic layer attached thereto.

TITANIUM ALLOY WITH IMPROVED PROPERTIES

A titanium alloy having high strength, fine grain size, and low cost and a method of manufacturing the same is disclosed. In particular, the titanium alloy offers a room temperature longitudinal low cycle fatigue (LCF) maximum stress of at least about 950 MPa over about 20,000 cycles and a room temperature transverse low cycle fatigue (LCF) maximum stress of at least about 970 MPa over about 25,000 cycles. The titanium alloy is particularly useful for a multitude of applications including components of aircraft engines. The titanium alloy comprises, in weight percent, about 6.0 to about 6.7% aluminum, about 1.4 to about 2.0% vanadium, about 1.4 to about 2.0% molybdenum, about 0.20 to about 0.42% silicon, about 0.17 to about 0.23% oxygen, maximum about 0.24% iron, maximum about 0.08% carbon and balance titanium with incidental impurities. 1. A titanium alloy comprising , in weight %:aluminum from 6.0 to 6.7;vanadium from 1.4 to 2.0;molybdenum from 1.4 to 2.0;silicon from 0.20 to 0.42;oxygen from 0.17 to 0.23;iron up to 0.24;carbon up to 0.08; and a room temperature longitudinal low cycle fatigue (LCF) maximum stress of at least about 950 MPa over about 20,000 cycles; and', 'a room temperature transverse LCF maximum stress of at least about 970 MPa over about 25,000 cycles., 'balance titanium with incidental impurities, wherein the alloy comprises at least one of2. The titanium alloy of claim 1 , wherein the alloy comprises at least one of:aluminum from about 6.3 to 6.7;vanadium from about 1.5 to about 1.9;molybdenum from about 1.5 to about 1.9;silicon from about 0.34 to about 0.38;oxygen from about 0.18 to about 0.21;iron from about 0.1 to about 0.2; andcarbon from about 0.01 to about 0.05.3. The titanium alloy of claim 1 , wherein the alloy comprises:aluminum from about 6.3 to 6.7;vanadium from about 1.5 to about 1.9;molybdenum from about 1.5 to about 1.9;silicon from about 0.34 to about 0.38;oxygen from about 0.18 to about 0.21;iron from about 0.1 to about 0.2; ...

TITANIUM ALLOY WITH IMPROVED PROPERTIES

A method of manufacturing a titanium alloy part with a composition, in weight %, of aluminum from about 6.0 to about 6.7; vanadium from about 1.4 to about 2.0; molybdenum from about 1.4 to about 2.0; silicon from about 0.20 to about 0.35; oxygen from about 0.18 to about 0.23; iron from about 0.16 to about 0.24; carbon from about 0.02 to about 0.06; and balance titanium, is provided. The method includes a first heat treatment on an ingot of the titanium alloy, forging of the ingot to break down the cast structure, a second heat treatment on the forged ingot, rolling the forged ingot to a plate, bar or billet, and annealing the plate, bar or billet below the beta transus temperature of the titanium alloy. The first and second heat treatments are between 40 and 200° C. and between 30 and 100° C. below the beat transus temperature, respectively. 1. A method of manufacturing a titanium alloy part , comprising:a. performing a first heat treatment on an ingot of a titanium alloy at a temperature between 40 and 200 degrees Centigrade above the beta transus temperature of the titanium alloy, forging the ingot to break down the cast structure of the ingot, and then cooling the forged ingot, wherein the titanium alloy comprises in weight percent (wt. %):aluminum from about 6.0 to about 6.7;vanadium from about 1.4 to about 2.0;molybdenum from about 1.4 to about 2.0;silicon from about 0.20 to about 0.35;oxygen from about 0.18 to about 0.23;iron from about 0.16 to about 0.24;carbon from about 0.02 to about 0.06; andbalance titanium with incidental impurities;b. performing a second heat treatment on the forged ingot at a temperature between 30 and 100 degrees Centigrade below the beta transus temperature and rolling the forged ingot to a plate, bar, or billet; andc. annealing the plate, bar or billet of the titanium alloy at a temperature below the beta transus temperature.2. The method of claim 1 , further comprising the step of reheating the forged ingot to a temperature between ...

Eye-Mounted Displays Including Embedded Solenoids

An augmented reality system may include an electronic contact lens and a power source. In order to enable the wireless transfer of power and data between the contact lens and the power source, one or both of the contact lens and the power source may contain solenoids. When current is driven through an embedded solenoid of the power source, the solenoid can produce a time-varying magnetic field. Likewise, when an embedded solenoid of the contact lens is in the presence of a time-varying magnetic field, a current is induced within the solenoid that may be used to power electronic components within the contact lens. Multiple solenoids may be embedded within the power source or the contact lens at positions and orientations that enable the contact lens to wirelessly receive power from a magnetic field produced by the power source at a variety of orientations. 1. An electronic contact lens comprising:a contact lens body;one or more electronic components embedded within the contact lens body; anda solenoid having a length l greater than its effective diameter D, where D=sqrt(4A/π) and A is a cross-sectional area of the solenoid, the solenoid contained within the contact lens body and configured to generate power for the electronic components from a time-varying magnetic field.2. The electronic contact lens of claim 1 , wherein the solenoid contains a core comprising a ferrite material or an iron alloy.3. The electronic contact lens of claim 1 , further comprising:a power circuit coupled to the solenoid for using current produced by the solenoid as power for the electronic components.4. The electronic contact lens of claim 1 , further comprising:an orientation estimation circuit coupled to the solenoid for determining an orientation of the contact lens based on power generated by the solenoid.5. The electronic contact lens of claim 1 , wherein the contact lens body comprises:a front surface, a back surface, and a material between the front surface and the back surface, ...

STRUCTURES AND PREPARATION METHODS FOR CATALYST COATED MEMBRANES FOR FUEL CELLS

Simplified methods for preparing a catalyst coated membrane (CCM) for solid polymer electrolyte fuel cells. The CCM has two reinforcing, expanded polymer sheets and the methods involve forming the electrolyte membrane from ionomer solution during assembly of the CCM. Thus, the conventional requirement to obtain, handle, and decal transfer solid polymer sheets in CCM preparation can be omitted. Further, CCM structures with improved mechanical strength can be prepared by orienting the expanded polymer sheets such that the stronger tensile strength direction of one is orthogonal to the other. Such improved CCM structures can be fabricated using the simplified methods. 1. A method of preparing a catalyst coated membrane assembly for a solid polymer electrolyte fuel cell , the catalyst coated membrane assembly comprising a solid polymer electrolyte membrane comprising a proton-conducting membrane ionomer , first and second expanded polymer sheets bonded to opposite sides of the solid polymer electrolyte membrane , and first and second catalyst layers comprising first and second catalysts respectively and bonded to the first and second expanded polymer sheets respectively on the sides opposite the solid polymer electrolyte , wherein the pores of the first expanded polymer sheet comprise membrane ionomer and first ionomer , and the pores of the second expanded polymer sheet comprise membrane ionomer and second ionomer; the method comprising:coating a first catalyst ink slurry comprising the first catalyst and the first ionomer onto a first supporting substrate;applying the first expanded polymer sheet to the first catalyst ink coating;coating a membrane ionomer solution comprising the membrane ionomer onto the first expanded polymer sheet;applying the second expanded polymer sheet to the membrane ionomer coating;annealing the membrane ionomer coating after the second expanded polymer sheet has been applied, thereby forming the solid polymer electrolyte membrane;coating a ...

ANION-CONDUCTING POLYMER

Disclosed herein are anion-conducting polymers that comprise a cationic benzimidazolium and imidazolium moieties. Methods of forming the polymers and membranes comprising the polymers are also provided. 2. The polymer of claim 1 , wherein the polymer is a salt formed with an anion selected from the group consisting of iodide claim 1 , hydroxide claim 1 , chloride claim 1 , bromide claim 1 , fluoride claim 1 , cyanide claim 1 , acetate claim 1 , carbonate claim 1 , nitrate claim 1 , sulfate claim 1 , phosphate claim 1 , triflate claim 1 , and tosylate.3. The polymer of claim 1 , wherein the imidazolium-containing moiety is included in a main chain of the polymer.4. The polymer of claim 1 , wherein the imidazolium-containing moiety is included in a pendant group of the polymer.5. The polymer of claim 1 , wherein the imidazolium-containing moiety is part of a crosslink of the polymer.6. The polymer of claim 1 , wherein Ris independently selected from the group consisting of methyl and trifluoromethyl.7. The polymer of claim 1 , wherein Ris independently selected from the group consisting of methyl and trifluoromethyl.8. The polymer of claim 1 , wherein Ris methyl.9. The polymer of claim 1 , wherein Ris independently selected from the group consisting of aryl and alkyl.10. An ionic membrane comprising a cationic polymer of .11. The ionic membrane of claim 10 , further comprising an anionic polymer.12. The ionic membrane of claim 11 , wherein the cationic polymer is ionically bound to the anionic polymer.13. The ionic membrane of claim 10 , further comprising an acidic polymer.14. The ionic membrane of claim 13 , wherein the acidic polymer comprises an imidazole-containing moiety.15. The ionic membrane of claim 13 , wherein the cationic polymer is bound to an anionic polymer created in situ after the deprotonation of the acidic polymer. This application is a division of U.S. patent application Ser. No. 14/385,115, filed Sep. 12, 2014, which is a national stage of ...

TITANIUM ALLOYS HAVING IMPROVED CORROSION RESISTANCE, STRENGTH, DUCTILITY, AND TOUGHNESS

Titanium alloys with an improved and unexpected combination of corrosion resistance, strength, ductility and toughness are provided. The titanium alloys contain molybdenum, nickel, zirconium, iron, and oxygen as alloying agents. Also the titanium alloys may be subjected to thermal treatments. The titanium alloys can include molybdenum between 3.0 to 4.5 wt. %, nickel between 0.1 to 1.0 wt. %, zirconium between 0.1 to 1.5 wt. %, iron between 0.05 to 0.3 wt. %, oxygen between 0.05 to 0.25 wt. %, and a balance of titanium and unavoidable impurities. The titanium alloys can have a yield strength between 550 to 750 MPa, a tensile strength between 700 to 900 MPa, an elongation to failure between 25 to 35%, a reduction in area between 55 to 70%, and a corrosion rate between 0.5 to 2.5 mils per year when exposed to 1 wt. % boiling hydrochloric acid per the ASTM G-31 test method. 1. A corrosion resistant titanium alloy comprising:molybdenum between 3.0 to 4.5 wt. %;nickel between 0.1 to 1.0 wt. %;zirconium between 0.1 to 1.5 wt. %;iron between 0.05 to 0.3 wt. %;oxygen between 0.05 to 0.25 wt. %; anda balance of titanium and unavoidable impurities.2. The corrosion resistant titanium alloy of further comprising a microstructure with a volume fraction of an alpha phase between 25 to 45% and a volume fraction of a beta phase between 55% and 75%.3. The corrosion resistant titanium alloy of claim 1 , wherein the volume fraction of the alpha phase is about 35% and the volume fraction of a beta phase is about 65%.4. The corrosion resistant titanium alloy of claim 1 , wherein final hot forging claim 1 , rolling claim 1 , or extrusion or other final hot working operation is performed at a temperature below a beta transus of the corrosion resistant titanium alloy so that the alloy can subsequently be cold worked/finished.5. The corrosion resistant titanium alloy of further comprising a yield strength between 550 to 930 MPa.6. The corrosion resistant titanium alloy of claim 5 , wherein ...

MOUNTABLE CABLE TIE WITH FINE ADJUSTMENT AND METHOD OF USE THEREOF

A mountable cable tie with fine adjustment with an elongated strap having a first strap end and a second strap end, the elongated strap having one or more rows of teeth or cross-bars formed crosswise on the elongated strap, and a plurality of holes positioned linear along the median between the one or more rows of teeth, at least one locking buckle positioned proximate the second strap end, the at least one locking buckle having at least one channel and at least one locking tang or pawl positioned within the locking buckle, wherein increased insertion of the first strap end into the locking head decreases the size of the loop of the elongated strap to secure the bundle. 1. A cable tie , to affix one or more elongated members to an object , the cable tie comprising:a strap configured with a first strap end and a second strap end and a top side and an underside, said strap configured with a plurality of cross-bars extended in two parallel spaced rows along each of said top side and said underside of said strap, said strap configured with one or more longitudinally spaced apertures therethrough, wherein said apertures are positioned between said two parallel rows of said plurality of cross-bars;a locking buckle positioned proximate said second strap end, said locking buckle is further configured to be approximately perpendicular to said second strap end, said locking buckle configured with a channel therethrough, wherein said channel is formed approximately perpendicular to said second strap end, said channel configured with two stationary pawls positioned therein to confront individually associated pairs of said plurality of cross-bars extended in two parallel spaced rows along said top side of said strap; and a tongue hingedly extended from said second strap end, said tongue configured with two ratchetable pawls facing said channel and opposing said stationary pawls, said two ratchetable pawls to confront individually associated pairs of said plurality of cross-bars ...

SEAL EXTRACTION TOOL

Tool for extracting annular carbon face seal from bore of equipment which seal is installed. Tool has extraction-tube for insertion into bore at entrance so, when extraction-tube is fully inserted into bore, multi-legged collet formed at distal-end of extraction-tube located within seal and proximal-end of extraction-tube accessible at entrance of bore. Tool has elongate-member extending along central passage of extraction-tube. Wedge element provided at distal-end of elongate-member located at mouth of collet. Proximal-end of elongate-member accessible at proximal-end of extraction-tube. Tool has support for reacting axial extraction force applied to extraction-tube to equipment. Tool has first-actuator at proximal-end of elongate-member. Tool configured so first-actuator causes wedge element to be pulled into collet, thereby expanding collet and causing to grip inner surface of seal. Tool has actuation second-actuator which operatively connects extraction-tube and support arrangement so actuation of second-actuator causes axial extraction force to extraction tube, whereby extraction force, reacted to equipment, extracts seal from bore when seal is gripped by collet. 1. A tool for extracting an annular carbon face seal from a bore of equipment in which the seal is installed , the tool having:an extraction tube for insertion into the bore at an entrance thereof such that, when the extraction tube is fully inserted into the bore, a multi-legged collet formed at a distal end of the extraction tube is located within the seal and a proximal end of the extraction tube is accessible at the entrance of the bore;an elongate member which extends along the central passage of the extraction tube, a wedge element provided at a distal end of the elongate member being located at a mouth of the collet, and a proximal end of the elongate member being accessible at the proximal end of the extraction tube;a support arrangement for reacting an axial extraction force applied to the ...

PUSH PIN WITH ANTIROTATIONAL STOPPER AND METHOD OF USE THEREOF

A push pin with rotational stopper and method of use thereof includes a push pin configured with a plurality of retention barbs extending outward from a surface of the insertion member, the insertion member configured with an anti-rotation section to friction fit therewith a sidewall of an aperture in the panel, an disc spring positioned proximate said anti-rotation section and configured to provide an opposing force to said retention barbs to limit insertion and removal therein the aperture in the panel. 1. A push pin for insertion into an aperture in a panel , said push pin comprising:an elongated member, said elongated member having a first member end and a second member end configured with one or more retention barbs extending outward from said elongated member and positioned therebetween said first member end and said second member end;a three or more sided anti-rotation section positioned proximate and integral thereto said first member end; anda disc spring positioned proximate and integral thereto said three or more sided anti-rotation section opposite said elongated member.2. The push pin of claim 1 , wherein said one or more retention barbs configured on an acute angle relative to said elongated member from said second member end to said first member end.3. The push pin of claim 2 , wherein said disc spring configured on an obtuse angle relative to said elongated member from said second member end to said first member end.4. The push pin of claim 3 , wherein said one or more retention barbs provides a counter removal force and said disc spring provides a counter insertion force to hold the push pin therein the aperture in the panel.5. The push pin of claim 4 , wherein said counter removal force opposes said counter insertion force.6. The push pin of claim 1 , wherein said three or more sided anti-rotation section configured as a polygon.7. The push pin of claim 1 , wherein said three or more sided anti-rotation section configured as a star.8. The push pin ...

Method and Apparatus for Creating a Supplier Data Set Containing Information about a Service Supplier

The subject matter relates to a method for creating a supplier data set containing information about a service supplier. A new tariff can be offered to the user by receiving an electronic copy of a bill from a client via a wide area network, extracting from the copy of the bill at least data characterizing the bill, comparing at least part of the extracted data characterizing the bill with bill templates stored within a database to determine a current type of tariff, analyzing the current type of tariff, and preparing the supplier data set based on the result of the analyzation. 1. A method for creating a supplier data set containing information about a service supplier comprising:receiving an electronic copy of a bill from a client via a wide area network,extracting from the copy of the bill at least data characterizing the bill,wherein extracting data from the bill comprises at least normalizing the bill by aligning the copy along a defined axis in particular using at least edge detection on the copy and aligning the edge,analyzing a spatial position of objects within the normalized bill,comparing at least part of the extracted data characterizing the bill with bill templates by finding objects being spatially arranged on the bill at similar positions on bill templates stored within a database to determine a current type of tariff,analyzing the current type of tariff, andpreparing the supplier data set based on the result of the analyzation.2. The method of claim 1 , further comprising:extracting from the copy of the bill at least data characterizing the user.3. The method of claim 2 , further comprising:extracting from the copy of the bill at least data characterizing usage.4. The method of claim 1 , wherein extracting data from the bill comprises optical character recognition.5. The method of claim 1 , wherein comparing the data characterizing the bill with bill templates comprises finding similar objects within the copy of the bill and the bill templates claim ...

METHOD FOR MANUFACTURING A MEMBRANE ASSEMBLY FOR A FUEL CELL WITH CATALYST-FREE EDGE TO THE FRAME; MEMBRANE ASSEMBLY AND FUEL CELL WITH MEMBRANE ASSEMBLY

A method for manufacturing a membrane assembly for a fuel cell, which membrane assembly includes a membrane with a catalyst layer and a frame arranged on the same side of the membrane and a gap between the catalyst layer and the frame. To allow an easy and cost-effective way for manufacturing such a membrane assembly, the manufacturing method may include the following steps: 2. The method according to claim 1 , wherein the positioning of the second decal layer is carried out in a way that the second decal layer overlaps a projection of the frame into a plane of the second decal layer.3. The method according to claim 1 , wherein the pressing is carried out with two pressing surfaces both overlapping the frame.4. The method according claim 1 , wherein prior to the positioning of the first decal layer and the second decal layer the frame is arranged on the membrane by a separate pressing procedure.5. The method according to claim 1 , wherein prior to the positioning of the first decal layer and the second decal layer the frame is positioned on the membrane to be fixed to the membrane in the following step of pressing the first decal layer and the second decal layer against each other.6. The method according to claim 1 , wherein a thickness of the frame is varied for adjusting the width of the gap.8. The membrane assembly according to claim 7 , wherein the first catalyst layer and the second catalyst layer form an electrode each.9. The membrane assembly according to claim 7 , wherein the first catalyst layer and the second catalyst are at least substantially fully overlapping with respect to their extension parallel to the membrane.10. A fuel cell with at least one membrane assembly according to . The present invention relates to a method for manufacturing a membrane assembly for a fuel cell, which membrane assembly comprises a membrane with a first side and a second side, a first catalyst layer arranged on the first side of the membrane and a second catalyst layer ...

Method for manufacturing a membrane assembly for a fuel cell with catalyst free edge areas; membrane assembly and fuel cell with membrane assembly

A method for manufacturing a membrane assembly for a fuel cell. To overcome a problem of chemical degradation at an edge of the membrane, the method comprises the following steps:positioning a first decal layer, which is made of the same material as a first catalyst layer, on a first side of the membrane,positioning a second decal layer, which is made of the same material as a second catalyst layer, on a second side of the membrane,pressing a compression pad, which is positioned on the first decal layer with the first decal layer and the second decal layer fully overlapping the compression pad, and the second decal layer against each other with the first decal layer and the membrane positioned in-between, whereby pressure on the first and the second decal layer is applied only in an area covered by the compression pad.

Insecticide/Miticide Composition Based on Fatty Acid Salts

The present proposals relate to an insecticide or miticide composition which demonstrates low phytotoxicity even at relatively high concentrations combined with highly effective insecticidal and miticidal activity. The composition comprises: a fatty acid/amino acid salt, the fatty acid component comprising: one or more unsaturated fatty acids having from 14 to 22 carbon atoms; and one or more saturated fatty acids having from 8 to 18 carbon atoms; wherein the one or more saturated fatty acids having from 8 to 18 carbon atoms forms at least 15 wt. % of the fatty acid component, and wherein the weight ratio of (unsaturated fatty acids having from 14 to 22 carbon atoms) to (saturated fatty acids having from 8 to 18 carbon atoms) is at least 1. Uses of the compositions and methods of killing insects or mites using the compositions also form part of the proposals. 1. An insecticide or miticide composition comprising: one or more unsaturated fatty acids having from 14 to 22 carbon atoms; and', 'one or more saturated fatty acids having from 8 to 18 carbon atoms;, 'a fatty acid/amino acid salt, the fatty acid component comprisingwherein the one or more saturated fatty acids having from 8 to 18 carbon atoms forms at least 15 wt. % of the fatty acid component, and wherein the weight ratio of (unsaturated fatty acids having from 14 to 22 carbon atoms) to (saturated fatty acids having from 8 to 18 carbon atoms) is at least 1.2. A composition according to claim 1 , wherein the one or more unsaturated fatty acids having 14 to 22 carbon atoms forms at least 50 wt. % of the fatty acid component.3. A composition according to claim 1 , wherein the amino acid component of the fatty acid/amino acid salt is selected from glycine claim 1 , arginine claim 1 , or lysine or combination thereof.4. A composition according to claim 3 , wherein the amino acid component is L-arginine.5. A composition according to claim 1 , wherein the one or more unsaturated fatty acids comprises one or more ...

Method For Dispensing False Eyelashes

The present invention relates to a method for dispensing false eyelashes from an apparatus, said method comprising the steps of a user advancing tape, said tape carrying a plurality of false eyelashes in a direction toward the dispensing tip of said apparatus, said apparatus comprising an upper and lower clamp, and said lower clamp being in an open position as said tape is advanced; said user halting advancement of said tape when one of said false eyelashes is sufficiently exposed for application by a user; said user positioning said lower clamp into a closed position which holds said false eyelash in a substantially fixed position for application to said user's eyelid; and said user applying said false eyelash to said user's eyelid. 1. A method for dispensing false eyelashes from an apparatus , said method comprising the steps of:a) a user advancing tape, said tape carrying a plurality of false eyelashes in a direction toward the dispensing tip of said apparatus, said apparatus comprising an upper and lower clamp, and said lower clamp being in an open position as said tape is advanced;b) said user halting advancement of said tape when one of said false eyelashes is sufficiently exposed for application by a user;c) said user positioning said lower clamp into a closed position which holds said false eyelash in a substantially fixed position for application to said user's eyelid; andd) said user applying said false eyelash to said user's eyelid.2. A method according to claim 1 , wherein said lower clamp is closed by a user activating a first button and said lower clamp is opened by said user activating a second button.3. A method according to claim 2 , wherein each of said first and second buttons comprises a tactile surface.4. A method according to claim 1 , wherein said apparatus comprises an eyelet claim 1 , said eyelet being positioned such that said tape is visible through said eyelet claim 1 , and wherein said eyelet comprises an alignment indicia.5. A method ...

DIFLUOROLACTAM COMPOSITIONS FOR EP4-MEDIATED OSTEO RELATED DISEASES AND CONDTIONS

Disclosed herein are compositions and methods of treating osteroporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) 6. The method of claim 5 , wherein:{'sup': 4', '5, 'sub': '3', 'Rand Rare independently H or CH;'}{'sup': 6', '3', '7, 'sub': 3', '10', '3', '10, 'Ris C-Calkyl, C-Calkynyl, or L-R;'}{'sup': '3', 'sub': 1', '6', '2', '6', '1', '6', '2', '6, 'Lis C-Calkylene or C-Calkynylene; wherein the C-Calkylene and C-Calkynylene are optionally substituted with 1, 2, 3, or 4 fluoro substituents; and'}{'sup': 7', '7, 'sub': 1', '4', '1', '3', '1', '3', '1', '3', '1', '3', '1', '3, 'Ris aryl, wherein Ris optionally substituted with 1, 2, 3, or 4 substituents selected from the group consisting of C-Calkyl, C-Chaloalkyl, cyano, halogen, C-Calkoxy, C-Chaloalkoxy, and —C-Calkylene-C-Calkoxy.'}9. The method of claim 5 , wherein:{'sup': '6', 'sub': 3', '10', '3', '10', '3', '10', '3', '10', '3', '10', '3', '10, 'Ris C-Calkyl, C-Calkenyl, C-Calkynyl, C-Chaloalkyl, C-Chaloalkenyl, or C-Chaloalkynyl.'}10. The method of claim 5 , wherein:{'sup': 6', '3', '7, 'Ris L-R;'}{'sup': '3', 'sub': 1', '6', '2', '6', '2', '6', '1', '6', '2', '6', '2', '6, 'Lis C-Calkylene, C-Calkenylene, or C-Calkynylene; wherein the C-Calkylene, C-Calkenylene, and C-Calkynylene are optionally substituted with 1, 2, 3, or 4 fluoro substituents; and'}{'sup': 7', '7, 'sub': 1', '4', '1', '3', '1', '3', '1', '3', '1', '3', '1', '3, 'Ris aryl, wherein Ris optionally substituted with 1, 2, 3, or 4 substituents selected from the group consisting of C-Calkyl, C-Chaloalkyl, cyano, halogen, C-Calkoxy, C-Chaloalkoxy, and —C-Calkylene-C-Calkoxy.'}11. The method of claim 5 , wherein:{'sup': '1', 'sub': 3', '7', '3', '7, 'Lis C-Calkylene, wherein the C-Calkylene is optionally substituted with 1, 2, 3, or 4 fluoro substituents.'}13. The method of claim 9 , wherein:{'sup': '1', 'sub': 3', '7', '3', '7, 'Lis C-Calkylene, wherein the C-Calkylene is optionally ...

Dual Pump Dispensing System

A dual pump dispensing system that features a reservoir within a reservoir arrangement. Each reservoir holds a different product, and has a separate pump dispenser. The pump dispensers are housed in a cartridge so that much of those mechanisms are not visible to the consumer. The pumps are sized to dose a specified ratio of each product, and the products are only mixed at the exit orifice of the nozzle or on the skin. 1. A dual pump dispensing system that comprises:{'b': '1', 'claim-text': [{'b': '1', 'i': 'c', 'a first reservoir (),'}, {'b': '1', 'i': 'd', 'a neck (), and'}, {'b': '1', 'i': 'f', 'access into the first reservoir through an opening () in the neck of the container;'}], 'a container () that has{'b': 60', '1', '1, 'i': 'd', 'a collar () that attaches to the neck () of the container ();'}{'b': '10', 'claim-text': [{'b': 10', '60, 'i': 'b', 'a top () that is secured into the collar ();'}, {'b': 10', '1', '1', '1, 'i': a', 'd', 'c, 'a bottom () that is inserted through the neck () of the container () and that extends down into the first reservoir () of the container;'}, {'b': 10', '10', '10', '10, 'i': e', 'f', 'c, 'claim-text': the passageway is opened at both ends of the cartridge, and', {'b': '10', 'i': 'a', 'the second reservoir is closed at the bottom () of the cartridge;'}], 'an interior wall () that divides the interior of the cartridge () into a passageway () and a second reservoir (), wherein], 'a cartridge () that comprises{'b': 30', '10', '10, 'i': 'f', 'claim-text': [{'b': 30', '1, 'i': a', 'c, 'a dip tube () that extends down into the first reservoir (), and'}, {'b': 30', '60, 'i': 'b', 'an upper stem () that protrudes through the collar ();'}], 'a first mechanical pump dispenser () that sits in the sits in the passageway () of the cartridge () and that has{'b': 40', '10', '10, 'i': 'c', 'claim-text': [{'b': 40', '10, 'i': b', 'a, 'a dip tube () that extends toward the bottom () of the cartridge, and'}, {'b': 40', '60, 'i': 'b', 'an upper stem ...

Powered Skin Care Device

A powered skin care device is provided with a vibrating motor that produces vibrations in a relatively gentle frequency and has a removable brush head that includes at least two types of bristles. A first group of bristles is for more gentle cleansing and a second group of bristles is for more aggressive cleansing. 1. A powered skin care device comprising:a housing with a hollow proximal end and a dosed distal end, a longitudinal axis defined from the proximal end to the distal end, the distal end forming a handle, the housing enclosing an electronic circuit connected to a battery, the proximal end defining an opening oriented at an oblique angle with respect to the longitudinal axis, the opening defining an inwardly directed annular surface;a head support platform defining an outer bearing surface and an inner surface;a skirt depending from the inner surface of the platform, the skirt defining an outwardly directed annular surface dimensioned to be received in spaced relation within the opening of the proximal end of the housing, the skirt further defining a cavity;at least one drive support structure located on the skirt or on the inner surface of the platform within the cavity;a vibration damper in the form of a resilient collar made from an elastically compliant material, the damper connecting the inwardly directed annular surface of the housing to the outwardly directed annular surface of the platform to resiliently secure the skirt in the opening of the hollow proximal end of the housing such that the outer bearing surface of the platform is positioned outside of the opening;a motorized vibratory mechanism secured to the at least one drive support and operably connected to the electronic circuit and the battery, the mechanism capable of generating vibrations in a frequency of about 80 Hz to 250 Hz when power is supplied from the battery, the vibratory mechanism secured to the drive support such as to cause the platform to vibrate;a switch in the electronic ...

Powered Skin Care Device

A powered skin care device is provided with a vibration damper between a vibrating motor and a handle of the device. The vibrating motor provides vibrations in a relatively gentle frequency and the brush head is provided with relatively soft bristles. 1. A powered skin care device comprising:a housing with a hollow proximal end and a dosed distal end, a longitudinal axis defined from the proximal end to the distal end, the distal end forming a handle, the housing enclosing an electronic circuit connected to a battery, the proximal end defining an opening oriented at an oblique angle with respect to the longitudinal axis, the opening defining an inwardly directed annular surface;a head support platform defining an outer bearing surface and an inner surface;a skirt depending from the inner surface of the platform, the skirt defining an outwardly directed annular surface dimensioned to be received in spaced relation within the opening of the proximal end of the housing, the skirt further defining a cavity;at least one drive support structure located on the skirt or on the inner surface of the platform within the cavity;a vibration damper in the form of a resilient collar made from an elastically compliant material, the damper connecting the inwardly directed annular surface of the housing to the outwardly directed annular surface of the platform to resiliently secure the skirt in the opening of the hollow proximal end of the housing such that the outer bearing surface of the platform is positioned outside of the opening;a motorized vibratory mechanism secured to the at least one drive support and operably connected to the electronic circuit and the battery, the mechanism capable of generating vibrations in a frequency of about 80 Hz to 250 Hz when power is supplied from the battery, the vibratory mechanism secured to the drive support such as to cause the platform to vibrate; anda switch in the electronic circuit operable to selectively provide power to the vibratory ...

Titanium alloys exhibiting resistance to impact or shock loading and method of making a part therefrom

Titanium alloys formed into a part or component used in applications where a key design criterion is the energy absorbed during deformation of the part when exposed to impact, explosive blast, and/or other forms of shock loading is described. The titanium alloys generally comprise a titanium base with added amounts of aluminum, an isomorphous beta stabilizing element such as vanadium, a eutectoid beta stabilizing element such as silicon and iron, and incidental impurities. The titanium alloys exhibit up to 70% or more improvement in ductility and up to a 16% improvement in ballistic impact resistance over a Ti-6Al-4V alloy, as well as absorbing up to 50% more energy than the Ti-6Al-4V alloy in Charpy impact tests. A method of forming a part that incorporates the titanium alloys and uses a combination of recycled materials and new materials is also described.

Powered Skin Care Device

A powered skin care device is provided with a snap-fit brush head that selectively attaches to a handle of the device. The vibrating motor provides vibrations in a relatively gentle frequency and the brush head is provided with relatively soft bristles. 1a housing with a hollow proximal end and a dosed distal end, a longitudinal axis defined from the proximal end to the distal end, the distal end forming a handle, the housing enclosing an electronic circuit connected to a battery, the proximal end defining an opening oriented at an oblique angle with respect to the longitudinal axis, the opening defining an inwardly directed annular surface;a head support platform defining an outer bearing surface and an inner surface, the outer bearing surface including a rim with at least one slot and at least one notch;a skirt depending from the inner surface of the platform, the skirt defining an outwardly directed annular surface dimensioned to be received in spaced relation within the opening of the proximal end of the housing, the skirt further defining a cavity;at least one drive support structure located on the skirt or on the inner surface of the platform within the cavity;a vibration damper in the form of a resilient collar made from an elastically compliant material, the damper connecting the inwardly directed annular surface of the housing to the outwardly directed annular surface of the platform to resiliently secure the skirt in the opening of the hollow proximal end of the housing such that the outer bearing surface of the platform is positioned outside of the opening;a motorized vibratory mechanism secured to the at least one drive support and operably connected to the electronic circuit and the battery, the mechanism capable of generating vibrations in a frequency of about 80 Hz to 250 Hz when power is supplied from the battery, the vibratory mechanism secured to the drive support such as to cause the platform to vibrate;a switch in the electronic circuit operable ...

A Radiation Reactor

The present invention relates to radiation reactors for sanitising fluids. In particular the present invention concerns a radiation reactor for a fluid, whereby the radiation reactor comprises a tubular casing having a fluid inlet and a fluid outlet, and, the radiation reactor also comprises a radiating element, with the radiation element being arranged within the tubular casing. As a fluid is passed into the tubular casing through the fluid inlet, a first direction of rotation is imparted to the fluid. The fluid is discharged from the tubular casing through the fluid outlet, after the fluid has been irradiated by the radiating element. In order to improve the efficiency of the irradiation process whilst maintaining flow rate through the radiation reactor, the tubular casing also comprises at least one protrusion on the inner wall of the casing and the protrusion extends into a flow path of the fluid such that the protrusion interrupts the first direction of rotation imparted to the fluid by directing the fluid out of the first direction of rotation. 1. A radiation reactor for a fluid , whereby the radiation reactor comprises a tubular casing and a radiating element , with the radiation element being arranged within the tubular casing such that a substantially annular space is created intermediate the radiating element and an inner wall of the tubular casing;the tubular casing further comprising a fluid inlet and a fluid outlet, whereby a fluid is passed into the substantially annular space of the tubular casing through the fluid inlet and the fluid is discharged from the substantially annular space of the tubular casing through the fluid outlet, with the fluid being irradiated by the radiating element within the tubular casing as the fluid passes through the substantially annular space of the tubular casing from the fluid inlet towards the fluid outlet;wherein a first direction of rotation is imparted to the fluid as it is passed into the substantially annular ...

DIFLUOROLACTAM COMPOSITIONS FOR EP4-MEDIATED OSTEO RELATED DISEASES AND CONDITIONS

Disclosed herein are compositions and methods of treating osteroporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) 6. The pharmaceutical composition of claim 5 , wherein:{'sup': 4', '5, 'sub': '3', 'Rand Rare independently H or CH;'}{'sup': 6', '3', '7, 'sub': 3', '10', '3', '10, 'Ris C-Calkyl, C-Calkynyl, or L-R;'}{'sup': '3', 'sub': 1', '6', '2', '6', '1', '6', '2', '6, 'Lis C-Calkylene or C-Calkynylene; wherein the C-Calkylene and C-Calkynylene are optionally substituted with 1, 2, 3, or 4 fluoro substituents; and'}{'sup': 7', '7, 'sub': 1', '4', '1', '3', '1', '3', '1', '3', '1', '3', '1', '3, 'Ris aryl, wherein Ris optionally substituted with 1, 2, 3, or 4 substituents selected from the group consisting of C-Calkyl, C-Chaloalkyl, cyano, halogen, C-Calkoxy, C-Chaloalkoxy, and —C-Calkylene-C-Calkoxy.'}9. The pharmaceutical composition of claim 5 , wherein:{'sup': '6', 'sub': 3', '10', '3', '10', '3', '10', '3', '10', '3', '10', '3', '10, 'Ris C-Calkyl, C-Calkenyl, C-Calkynyl, C-Chaloalkyl, C-Chaloalkenyl, or C-Chaloalkynyl.'}10. The pharmaceutical composition of claim 5 , wherein:{'sup': 6', '3', '7, 'Ris L-R;'}{'sup': '3', 'sub': 1', '6', '2', '6', '2', '6', '1', '6', '2', '6', '2', '6, 'Lis C-Calkylene, C-Calkenylene, or C-Calkynylene; wherein the C-Calkylene, C-Calkenylene, and C-Calkynylene are optionally substituted with 1, 2, 3, or 4 fluoro substituents; and'}{'sup': 7', '7, 'sub': 1', '4', '1', '3', '1', '3', '1', '3', '1', '3', '1', '3, 'Ris aryl, wherein Ris optionally substituted with 1, 2, 3, or 4 substituents selected from the group consisting of C-Calkyl, C-Chaloalkyl, cyano, halogen, C-Calkoxy, C-Chaloalkoxy, and —C-Calkylene-C-Calkoxy.'}11. The pharmaceutical composition of claim 5 , wherein:{'sup': '1', 'sub': 3', '7', '3', '7, 'Lis C-Calkylene, wherein the C-Calkylene is optionally substituted with 1, 2, 3, or 4 fluoro substituents.'}13. The pharmaceutical composition of claim 9 , wherein ...

HIGH-STRENGTH ALPHA-BETA TITANIUM ALLOY

A method of making an alpha-beta titanium alloy is provided. The method includes forming a melt and solidifying the melt to form an ingot. The melt composition includes concentrations of Al from about 4.7 wt. % to about 6.0 wt. %; V from about 6.5 wt. % to about 8.0 wt. %; Si at less than 1 wt. %; Fe at up to about 0.3 wt. %; 0 at less than 1 wt. %; and a balance of Ti and incidental impurities. Furthermore, the Al/V ratio in the melt is equal to the concentration of the Al divided by the concentration of the V in weight percent is from about 0.65 to about 0.8. 1. A method of making a high-strength alpha-beta titanium alloy comprising: forming a melt comprising:Al at a concentration from about 4.7 wt. % to about 6.0 wt. %;V at a concentration from about 6.5 wt. % to about 8.0 wt. %;Si at a concentration of less than 1 wt. %;Fe at a concentration of up to about 0.3 wt. %;O at a concentration of less than 1 wt. %; andTi and incidental impurities as a balance; and solidifying the melt to form an ingot;wherein an Al/V ratio in the melt is equal to the concentration of the Al divided by the concentration of the V in weight percent is from about 0.65 to about 0.8.2. The method of claim 1 , wherein the melting comprises one or more of: vacuum arc remelting claim 1 , electron beam cold hearth melting claim 1 , and plasma cold hearth melting.3. The method of claim 1 , further comprising:thermomechanically processing the ingot to form a workpiece; andsolution heat treating and aging the workpiece, wherein the solution treated and aged workpiece comprises an elongation of at least 10% at room temperature.4. The method of claim 3 , wherein the thermomechanical processing comprises one or more of: open die forging claim 3 , closed die forging claim 3 , rotary forging claim 3 , hot rolling claim 3 , and hot extrusion.5. The method of claim 3 , wherein the heat treating comprises beta annealing.6. The method of claim 5 , wherein the heat treating comprises:solution treating the ...

HIGH-STRENGTH ALPHA-BETA TITANIUM ALLOY

An alpha-beta titanium alloy is provided. The alpha-beta titanium alloy composition includes concentrations of Al from about 4.7 wt. % to about 6.0 wt. %; V from about 6.5 wt. % to about 8.0 wt. %; Si from about 0.15 wt. % to about 0.6 wt. %; Fe up to about 0.3 wt. %; O from about 0.15 wt. % to about 0.23 wt. %; Ti and incidental impurities as a balance. The alpha-beta titanium alloy may have a solution treated and aged microstructure and an elongation of at least about 10% at room temperature. Also, the alpha-beta titanium alloy may have an Al/V ratio from about 0.65 to about 0.8, the Al/V ratio being equal to the concentration of the Al divided by the concentration of the V in weight percent. 1. A high-strength alpha-beta titanium alloy comprising:Al at a concentration of from about 4.7 wt. % to about 6.0 wt. %;V at a concentration of from about 6.5 wt. % to about 8.0 wt. %;Si at a concentration of from about 0.15 wt. % to about 0.6 wt. %;Fe at a concentration of up to about 0.3 wt. %;O at a concentration of from about 0.15 wt. % to about 0.23 wt. %;Ti and incidental impurities as a balance;a solution treated and aged microstructure; and 'wherein an Al/V ratio is from about 0.65 to about 0.8, the Al/V ratio being equal to the concentration of the Al divided by the concentration of the V in weight percent.', 'an elongation of at least about 10% at room temperature,'}2. The alloy of further comprising an additional alloying element at a concentration of less than about 1.5 wt. % claim 1 , the additional alloying element being selected from the group consisting of Sn and Zr.3. The alloy of further comprising Mo at a concentration of less than 0.6 wt. %.4. The alloy of claim 1 , comprising:Al at a concentration of from about 5.0 to about 5.6 wt. %;NoneV at a concentration of from about 7.2 wt. % to about 8.0 wt. %;Si at a concentration of from about 0.2 wt. % to about 0.5 wt. %;C at a concentration of from about 0.02 wt. % to about 0.08 wt. %; andO at a concentration ...

Multi-Coil Field Generation In An Electronic Contact Lens System

An augmented reality system includes an electronic contact lens and a plurality of conductive coils to be worn, for instance, around a neck, around an arm, or on a chest of a user. The conductive coils can inductively couple to the electronic contact lens by producing magnetic fields that the electronic contact lens can convert into power. A direction of the resulting magnetic at the electronic contact lens can rotate over time, enabling the electronic contact lens to periodically form a strong inductive coupling with the plurality of conductive coils despite the orientation of the electronic contact lens. The electronic contact lens can also output a feedback signal representative of the power produced at the electronic contact lens or an orientation signal representative of the orientation of the eye, and the magnetic fields produced by the conductive coils can be altered based on the feedback signal or orientation signal.

Multi-Coil Field Generation in an Electronic Contact Lens System

An augmented reality system includes an electronic contact lens and a plurality of conductive coils to be worn, for instance, around a neck, around an arm, or on a chest of a user. The conductive coils can inductively couple to the electronic contact lens by producing magnetic fields that the electronic contact lens can convert into power. A direction of the resulting magnetic at the electronic contact lens can rotate over time, enabling the electronic contact lens to periodically form a strong inductive coupling with the plurality of conductive coils despite the orientation of the electronic contact lens. The electronic contact lens can also output a feedback signal representative of the power produced at the electronic contact lens or an orientation signal representative of the orientation of the eye, and the magnetic fields produced by the conductive coils can be altered based on the feedback signal or orientation signal.

CONTACT LENSES WITH OXYGEN-IMPERMEABLE OPTICAL FILTERS

A scleral contact lens has a core containing an optical filter. The core and/or the optical filter may comprise oxygen impermeable material, such that an overall oxygen permeability of the core is insufficient to oxygenate a user's cornea when wearing the contact lens. To provide oxygenation to the user's cornea, the contact lens further comprises an outer covering, and an inner covering, each corresponding to a thin layer of gas-permeable material shaped to form a respective manifold between the covering and the core. Oxygen from an outside environment passes through the outer covering to reach the outer manifold, through an air path formed within the core to the inner manifold, and through the inner covering to reach the cornea of the user's eye. 1. A scleral contact lens that mounts to a sclera of an eye , the scleral contact lens comprising:a core comprising an optical filter covering a central area of the contact lens, wherein an oxygen permeability of the core is insufficient to oxygenate the cornea;a gas-permeable inner covering and inner manifold beneath the core, the inner covering disposed over the cornea of the eye;a gas-permeable outer covering and outer manifold, the outer covering exposed to oxygen in the external environment; andat least one oxygen pathway traversing the core from the outer manifold to the inner manifold.2. The scleral contact lens of wherein the central area of the contact lens consists of an area of the contact lens that is within a threshold distance of a central axis of the contact lens.3. The scleral contact lens of wherein the central area of the contact lens includes an area of the contact lens that is within 5 mm of a central axis of the contact lens.4. The scleral contact lens of wherein the optical filter has a thickness of not more than 50 μm.5. The scleral contact lens of wherein the core has a thickness of not more than 250 μm.6. The scleral contact lens of wherein the core consists of the optical filter.7. The scleral ...

Power Generation Necklaces With Field Shaping Systems

An augmented reality system including a necklace and a contact lens display can be used to project information from the contact lens display onto the retina of the wearer's eye. In one example, the necklace generates a time-varying magnetic field (TVMF) that provides energy and information to the contact lens display via inductive coupling. The necklace can be configured to decrease the amount of energy absorbed by the body of the wearer and increase power transfer to the contact lens display. The necklace includes a conductive loop and one or more bucking loops that are positioned to increase transmitted energy while reducing the amount of energy absorbed by the human body. The amount of current travelling in one direction through the loops of the necklace is greater than the amount of current travelling in the opposite direction through the loops of the necklace. The necklace can include any number of signal generators and winding patterns for the loops. 1. A system comprising:a necklace;one or more first conductive loops extending along a band of the necklace to provide energy to an electronic contact lens via inductive coupling;one or more second conductive loops extending along the band of the necklace, the one or more second conductive loops carrying current in an opposite direction from current carried by the one or more first conductive loops; andone or more driver circuits to drive current through the one or more first conductive loops and the one or more second conductive loops, such that a first total current travelling through the one or more first conductive loops in a first direction has a first strength and a second total current travelling through the one or more second conductive loops is in a second direction has a second strength different from the first strength.2. The system of claim 1 , wherein the one or more first conductive loops are connected in series with the one or more second conductive loops claim 1 , the first conductive loops and the ...

A rainwater treatment process

A rainwater treatment assembly (1) comprising a rainwater storage tank (2) and a treatment tank (3). Rainwater is delivered from the storage tank (3) where ozone is injected into it at regular time intervals. The ozone kills bacteria and oxidises transition metals.

METHOD FOR RAPIDLY CHARGING AN ELECTRIC VEHICLE FROM A LIGHT DUTY CHARGING SITE COMPRISING A RESIDENTIAL DWELLING OR A SMALL OFF GRID POWER STATION

A fast-charging method is provided for rapidly charging an electric vehicle at a light-duty charging site comprising a residential dwelling or a small off-grid power station. The fast charging method incorporates an intermediate battery bank, or power buffer, that stores energy between EV charging cycles, then discharges the stored energy into the EV at a higher rate than the primary electric power source for the charging system. The power buffer thereby acts as a power multiplier that accelerates the rate of charge of an electric vehicle. Substantial power multiplication factors are possible at light-duty charging sites, resulting in large improvements in electric vehicle charging rates. The method may be applied using a number of primary power sources including AC from the utility grid, DC from photovoltaic panels, or power from other electric vehicle chargers (including both AC and DC electric vehicle chargers). 1. A method for rapidly charging an electric vehicle from a residential dwelling , the method comprising:providing a primary electric power source at said residential dwelling;providing a power buffer;providing a fast-discharge battery within said power buffer; 'providing an energy storage load within said electric vehicle;', 'providing a buffer/load interface;'}providing an electric vehicle battery within said energy storage load;providing means for transmitting power from said primary electric power source at said residential dwelling to said fast-discharge battery within said power buffer;providing means for transmitting power from said fast-discharge battery within said power buffer to said buffer/load interface;providing means for transmitting power from said buffer/load interface to said electric vehicle battery within said energy storage load; 'whereby a power buffer energy may be accumulated in said fast-discharge battery, whereby said power buffer energy may be accumulated and stored in said fast-discharge battery whether or not said electric ...

Complexed metals bonded to inorganic oxides

Complexed metals bonded to inorganic oxides are a new class of heterogeneous catalysts which display high upper reaction temperature limits, exceptional chemical and thermal stability and good catalytic activity for organic compound conversion. The catalyst of this invention comprises a substrate having a minimum surface area of about 10 m 2 /g and having pores with a minimum pore diameter of about 5 Angstrom Units, said substrate being modified by at least one amine functional member coordinated to a metal function, said amine functional member acting as a bridging member between said substrate and said metal function. Also herein provided is a novel method of organic compound conversion which comprises contacting said organic compound with a catalytic amount of the above catalyst under organic compound conversion conditions.

Organic compound conversion

Organic compound conversion in the presence of a new class of heterogeneous catalyst is provided. Said new class of heterogeneous catalyst comprises a substrate having a minimum surface area of about 10 m 2 /g and having pores with a minimum pore diameter of about 5 Angstrom Units, said substrate being modified by at least one amine functional member coordinated to a metal function, said amine functional member acting as a bridging member between said substrate and said metal function.

Fluidized bed calciner apparatus

An apparatus for remotely calcining a slurry or solution feed stream of toxic or hazardous material, such as ammonium diurante slurry or uranyl nitrate solution, is disclosed. The calcining apparatus includes a vertical substantially cylindrical inner shell disposed in a vertical substantially cylindrical outer shell, in which inner shell is disposed a fluidized bed comprising the feed stream material to be calcined and spherical beads to aid in heat transfer. Extending through the outer and inner shells is a feed nozzle for delivering feed material or a cleaning chemical to the beads. Disposed in and extending across the lower portion of the inner shell and upstream of the fluidized bed is a support member for supporting the fluidized bed, the support member having uniform slots for directing uniform gas flow to the fluidized bed from a fluidizing gas orifice disposed upstream of the support member. Disposed in the lower portion of the inner shell are a plurality of internal electric resistance heaters for heating the fluidized bed. Disposed circumferentially about the outside length of the inner shell are a plurality of external heaters for heating the inner shell thereby heating the fluidized bed. Further, connected to the internal and external heaters is a means for maintaining the fluidized bed temperature to within plus or minus approximately 25° C. of a predetermined bed temperature. Disposed about the external heaters is the outer shell for providing radiative heat reflection back to the inner shell.

Substituted pyridinones

Disclosed are compounds of Formula I and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , and R 5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

Gripping apparatus for a fork of a fork lift

A gripping apparatus for a fork of a fork lift includes a gripping portion and at least one mounting portion for removably securing the gripping apparatus to the fork. Openings are formed between the at least one mounting portion and the gripping portion for receiving the fork therethrough. The gripping apparatus is constructed of a high friction material.

Wear coating applied to an atomic force probe tip

A probe tip manufactured from a conically shaped quartz tip etched to a fine apex. The quartz tip is coated with about 1 μm of a hard material such as silicon nitride. A probe tip having dimensions of about 100 nm×1 μm is then machined from the hard material adjacent to the apex of the quartz tip along the axis of the quartz tip. The machining is preferably performed by focused ion beam milling.

Electrical service interface system

An electrical service interface system include an energy storage device and inverter mounted to a transformer tower, wherein each of the energy storage device and inverter include guide wheels configured to rollably mount the energy storage device and inverter to corresponding guide rails mounted to a support pad, and to align the energy storage device to the inverter, and the inverter to the transformer tower. In an installed configuration, the energy storage device electrically and mechanically couples to the inverter via a DC connector and one or more latching mechanisms, and the inverter mechanically and electrically couples to the transformer tower via an AC connector and one or more latching mechanisms.

Electrical service interface system

An electrical service interface system include a configurable device and inverter mounted to an equipment tower, wherein each of the configurable device and inverter include alignment devices configured to rollably mount the configurable device and inverter to corresponding guides mounted to a support pad, and to align the configurable device to the inverter, and the inverter to the equipment tower. In an installed configuration, the configurable device electrically and mechanically couples to the inverter via a DC connector and one or more mounting systems, and the inverter mechanically and electrically couples to the equipment tower via an AC connector and one or more mounting systems.

Seismic impulse source transducer

SEISMIC IMPULSE SOURCE TRANSDUCER ABSTRACT OF THE DISCLOSURE A spark discharge acoustic pulse transducer for borehole operation provides an insulating ceramic barrier which contains a small cross-section aperture separating two bodies of electrolyte through which the two zones of liquid make contact. An electrical arc discharge is caused to occur through the aperture to produce a transient pressure pulse and associated acoustic pulse which is coupled to the geologic formation at the borehole wall. The specific shape and geometry of the aperture channel in the insulating barrier being exponentially shaped provides a means for controlling the waveform and frequency spectrum of the acoustic pulse. The transducer has an elastic outer housing and an elastic inner housing with hydraulic fluid between the inner and outer housings. The pressure of the hydraulic fluid may be increased to expand the outer housing against a borehole prior to a spark discharge. The transducer is also provided with a system for venting gas produced as a result of the spark discharge.

Spark discharge acoustic pulse transducer for borehole operation

Borehole seismic impulse source transducer comprises an elastic, electrically insulating sleeve which together with downhole and uphole end members defines a chamber for receiving electrolyte. An insulator divides the chamber into upper and lower volumes connected by an aperture in the insulator. Spaced electrodes extend into the resp. volumes. Gas build up from prodn of arc discharges can be intermittently vented. A reaction mass surrounds approx. one half of the chamber sidewall to reflect a pressure wave incident on the mass from the arc discharge.

Sofa bed

CYLINDRICAL ELECTROMAGNETIC TRANSDUCER WITH TRANSVERSE VIBRATIONS

Removing impurities from fluid suspensions

Preparation of drug delivery formulations by electrotransport

A rainwater treatment unit

The present invention is directed to an assembly and a method of treating rainwater to produce potable water. A compact and easy-to-install apparatus is achievable as a result of a simple, yet highly effective sanitisation method. Rainwater is entrained with a gas, and the entrained rainwater is irradiated with an ultraviolet (UV) light to fully sanitise the rainwater. The UV light is used during the irradiation of the entrained water and is also used to form a gaseous bactericide which is used to entrain the rainwater. None of the disadvantages of the prior art systems apply to any rainwater treatment systems which use this method. All of the connections between the component parts may be already provided for in this rainwater treatment unit, and consequently both installation and maintenance costs will be significantly reduced in comparison to the rainwater treatment systems which are known from the prior art.

System and method for highlighting dependent slides while editing master slides of a presentation

A presentation document editing system provides master slides that can be associated with one or more other dependent slides in the presentation. When a slide in the presentation is edited, a preview of other slides in the presentation is displayed. When a master slide is edited, any dependent slides are shown in the preview with a visual indicator to distinguish the dependent slides from other slides in the presentation.

Supstituted pyridinones as modulators of p38 map kinase

Ar = nesupstituirani ili supstituirani aril ili heteroarilR= alkil sa 1 do 8 ugljikovih atoma, aril ili aralkilR= O, OH, CN ili halogen ia = jednostruka veza ili dvostruka veza. Ar = unsubstituted or substituted aryl or heteroarylR = alkyl of 1 to 8 carbon atoms, aryl or aralkylR = O, OH, CN or halogen ia = single bond or double bond.

A mould for use in the forming of a hollow cylindrical concrete structure

A mould for use in the forming of a hollow cylindrical concrete structure (30), which mould comprises at least three longitudinally extending part-cylindrical members (6) which can be assembled to form a hollow complete cylinder on which the concrete structure is formed when the complete cylinder is horizontally positioned, and which can be collapsed after the concrete structure has been formed such that the part-cylindrical members (6) can be withdrawn from one end of the cylindrical structure and re-used. <IMAGE>

Block perfluorosulfonic acid ionomer for improved fuel cell performance

A block copolymer perfluorosulfonic acid ionomer is disclosed with low average equivalent weight comprising both hydrophilic and hydrophobic blocks of relatively low and relatively high equivalent weights respectively. Such ionomer can be made by polymerizing a suitable mixture of hydrophilic and hydrophobic monomers and then, upon reaching a certain molecular weight, performing a second polymerizing using the same monomers but with a greater relative amount of hydrophobic monomer. Such ionomer should provide both improved mechanical properties and performance in solid polymer electrolyte fuel cells. It is expected that the presence of the larger hydrophobic blocks and the larger hydrophilic blocks would enhance mechanical stability and increase proton conductivity respectively, particularly under hot and dry operating conditions in automotive fuel cell applications.

Patient monitoring system and apparatus

Seismic impulse source transducer

Process and apparatus for producing finned tubing

Method of estimating a vehicle load

Fresh cosmetic composition delivery system

A fresh composition delivery system includes a package with two compartments separated by a foil seal for separating a cosmetically acceptable carrier from an unstable active ingredient. An elastomeric bulb with a dart can be actuated by the user to pierce the foil seal so that the carrier and the active can be mixed in the package to form a composition shortly before use. For the resulting mixed composition, the level of the unstable active ingredient in the composition decreases by less than 6% over 7 days when stored at 25°C at 60% relative humidity.

Production of phosphonopyrazoles

Novel compounds with activity as chemical hybridizing agents and methods for synthesis of such compounds are disclosed. These compounds are useful in producing hybrid wheat ( Triticum aesativum ) and other crops.

ANTITROMBIN AND ANTI-BLOOD TRIFUNCTIONAL PEPTIDES

Bicycle trainer

PIRIDINONES REPLACED AS MODULATORS OF P38 MAP QUINASAS

Se describen compuestos de la Formula I y sus sales farmaceuticamente aceptables, en los que R1, R2, R3, R4 y R5 se definen en la presente. Estos compuestos son utiles para tratar enfermedades y afecciones causadas o exacerbadas por la actividad de p38 MAP quinasa desregulada y/o FNT. Tambien se describen composiciones farmaceuticas que contienen los compuestos, metodos para preparar los compuestos y metodos de tratamiento que utilizan los compuestos.

Method and apparatus for removing fluids from drill cuttings

A method and apparatus is provided for removing fluids, particularly entrained and/or adherent fluids, from drill cuttings generated during the well drilling process. A generally cylindrical wire-wrapped screen having a bore therethrough rotates about its longitudinal axis. Suction pressure is applied through the inner bore of the cylindrical wire-wrapped screen. As fluid-laden drill cuttings are deposited on the outer surface of the cylindrical wire-wrapped screen, fluids are drawn off of the cuttings and evacuated from the inner bore of the cylindrical wire-wrapped screen. Solid components of the cuttings remain on the outer surface of the cylindrical wire-wrapped screen and eventually roll off the screen. A scraping member is provided to agitate cuttings deposited on the outer surface of the cylindrical wire-wrapped screen.

Composite proton conducting electrolyte with improved additives for fuel cells

Improved additives can be used to prepare polymer electrolyte for membrane electrode assemblies in polymer electrolyte fuel cells. Use of these improved additives can not only improve durability and performance, but can also provide a marked performance improvement during initial conditioning of the fuel cells. The additives are chemical complexes comprising certain metal and organic ligand components.

Modified solid catalyst materials

Refractory metal oxide solid materials, characterized by the presence of surface hydroxyl groups, which have undergone modification by being subjected to the sequential steps of (1) silylating, (2) calcining and (3) steaming are provided. Said silylating step is accomplished by contacting said solid material with an organic-or halogen-substituted silane at a temperature of between about 25°C and about 500°C to effect bonding between said silane and the surface hydroxyl groups of said solid. Said calcining step is accomplished by heating the resulting silylated solid at a temperature and for a time sufficient to remove substantially all of any introduced organic or halogen substituent. Said steaming step is accomplished by contacting the resulting calcined solid with an atmosphere containing at least 2 percent by volume of steam at a temperature of between about 900°F and about 1600°F for at least about 1/2 hour. Organic compound conversion, e.g. hydrocarbon compound conversion, such as, for example, cracking with one or more of said modified refractory metal oxide solid materials as a catalyst is also provided.

Control of a vehicle having an automatic transmission to compensate for ambient air density

Organic crosslinking of polymers for co _flooding profile control

ORGANIC CROSSLINKING OF POLYMERS ABSTRACT A process for recovering hydrocarbonaceous fluids from a formation having a substantially low pH where a rehealable gel prepared ex-situ is used to close off a zone of greater permeability. Said gel is obtained by mixing into an aqueous medium sufficient biopolymer amounts of a Xanthan or Alcaligene polysaccharide. This mixture is maintained at a pH of 5.5 while an aminoplast resin in excess of 4,000 ppm is added thereto which causes said gel to form in 0.5 to 6 hours. The resultant gel is suitable for use in a carbon-dioxide flood process. Said gels are very stable at a pH of less than 5.5.

Insecticide/acaricide composition based on salts of fatty acids

Una composición insecticida o acaricida que comprende: una sal de ácido graso/aminoácido, comprendiendo el componente de ácido graso: uno o más ácidos grasos insaturados que tienen de 14 a 22 átomos de carbono; y uno o más ácidos grasos saturados que tienen de 8 a 18 átomos de carbono; en la que los, uno o más, ácidos grasos saturados que tienen de 8 a 18 átomos de carbono forman al menos el 15% en peso del componente de ácido graso, y en la que la relación en peso de ácidos grasos insaturados que tienen de 14 a 22 átomos de carbono con respecto a ácidos grasos saturados que tienen de 8 a 18 átomos de carbono es al menos 1; en la que el componente de aminoácido de la sal de ácido graso/aminoácido es arginina. An insecticidal or acaricidal composition comprising: a fatty acid/amino acid salt, the fatty acid component comprising: one or more unsaturated fatty acids having from 14 to 22 carbon atoms; and one or more saturated fatty acids having 8 to 18 carbon atoms; wherein the one or more saturated fatty acids having from 8 to 18 carbon atoms form at least 15% by weight of the fatty acid component, and wherein the weight ratio of unsaturated fatty acids having from 14 to 22 carbon atoms with respect to saturated fatty acids having 8 to 18 carbon atoms is at least 1; wherein the amino acid component of the fatty acid/amino acid salt is arginine.

Separation of metallic sulfids from ores.

Substituted pyrazolyl compounds for the treatment of inflammation

The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.

Cyclic neurokinin a antagonists

Antagonists of neurokinin A which are novel cyclic hexapeptide and octapeptide compounds are described. The antagonism is confirmed using conventional competitive binding and biochemical assays as well as conventional physiological tests and the use of these derivatives in a variety of conditions in which neurokinin A is implicated is also described.

Anion-conducting polymer

Disclosed herein are anion-conducting polymers that comprise a cationic benzimidazolium and imidazolium moieties. Methods of forming the polymers and membranes comprising the polymers are also provided.

Measurement Of Nitrogen Content In A Gas Mixture By Transforming The Nitrogen Into A Substance Detectable With Nondispersive Infrared Detection

A method of determining the amount of nitrogen in a gas mixture. The constituent gases of the mixture are dissociated and transformed to create a substance that may measured using nondispersive infrared adsorption techniques.

Substituted pyrazolyl compounds for the treatment of inflammation

The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.

A radiation reactor

The present invention relates to radiation reactors for sanitising fluids. In particular the present invention concerns a radiation reactor for a fluid, whereby the radiation reactor comprises a tubular casing having a fluid inlet and a fluid outlet, and, the radiation reactor also comprises a radiating element, with the radiation element being arranged within the tubular casing. As a fluid is passed into the tubular casing through the fluid inlet, a first direction of rotation is imparted to the fluid. The fluid is discharged from the tubular casing through the fluid outlet, after the fluid has been irradiated by the radiating element. In order to improve the efficiency of the irradiation process whilst maintaining flow rate through the radiation reactor, the tubular casing also comprises at least one protrusion on the inner wall of the casing and the protrusion extends into a flow path of the fluid such that the protrusion interrupts the first direction of rotation imparted to the fluid by directing the fluid out of the first direction of rotation.

Variable multi-stage arc discharge acoustic pulse source transducer

A method of and a system for remotely controlling an adjustable, electrodeless arc discharge acoustic pulse transducer for borehole and underwater operations using high-energy arc discharges to generate high power seismic and acoustic pulses capable of being easily and remotely adjusted in time duration and magnitude such that they can be customized to create waveforms of preferred shapes. The transducer has an insulating ceramic barrier which contains a biconical aperture separating two bodies of electrolyte through which the two zones of liquid make contact and electrically adjustable circuits for switching supplemental amounts of stored electrical energy into the arc discharge circuit at successively delayed time intervals to lengthen the arc discharge current pulse to create the desired waveform shape for detecting variations in the geological features of the formations being probed or for use in ocean acoustic or sonar applications.

Sofa

A rainwater treatment unit

The present invention is directed to an assembly and a method of treating rainwater to produce potable water. A compact and easy-to-install apparatus is achievable as a result of a simple, yet highly effective sanitisation method. Rainwater is entrained with a gas, and the entrained rainwater is irradiated with an ultraviolet (UV) light to fully sanitise the rainwater. The UV light is used during the irradiation of the entrained water and is also used to form a gaseous bactericide which is used to entrain the rainwater. None of the disadvantages of the prior art systems apply to any rainwater treatment systems which use this method. All of the connections between the component parts may be already provided for in this rainwater treatment unit, and consequently both installation and maintenance costs will be significantly reduced in comparison to the rainwater treatment systems which are known from the prior art.

Substituted pyridinones as modulators of p38 map kinase

Substituted pyridinones as modulators of p38 map kinase

Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein R~1, R~2, R~3, R~4, and R~5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

Respirator cartridges

A respirator cartridge 100 that has an inlet 18, an outlet 22 and a reservoir 14 sealingly interposed between the inlet 18 and the outlet 22. One-way valves 40, 42 are respectively provided at the inlet 18 and the outlet 22 and a radiation emitter 30 is arranged to emit radiation into the reservoir 14. The reservoir 14 may be configured with a series of interconnected sub-compartments 14a, fig.4, or possibly a slidable baffle 102, such that the dwell time of air in the reservoir 14 is long enough for the radiation emitter 30 to neutralise pathogens within the air in the reservoir 14. The radiation emitter 30 may comprises an ultra-violet UV lamp, which may be a light-emitting-diode LED or an excimer lamp. The reservoir 14 may have a volume of an adult tidal breathing volume. A filter 24 may be located upstream of, and sealingly connected to, the inlet 18, where the filter 24 may comprises a microbial filter. Also, a respirator comprising: a face mask and/or an oral-nasal unit comprising an inhale aperture to which a respirator cartridge 100 is affixed, and an exhale aperture fitted a one-way exhale valve.