SURGICAL GUIDE AND METHOD FOR GUIDING A THERAPY DELIVERY DEVICE INTO THE PTERYGOPALATINE FOSSA

A surgical guide to facilitate delivery of a therapy delivery device into the pterygopalatine fossa of a subject includes a curvilinear body having a distal end portion, a proximal end portion, and an intermediate portion extending between the distal and proximal end portions. The proximal end portion is defined by oppositely disposed first and second surfaces. The proximal end portion and the intermediate portion define a longitudinal plane that extends between the proximal and distal end portions. The distal end portion has an arcuate configuration relative to the longitudinal plane and is defined by oppositely disposed third and fourth surfaces. 1. A surgical guide to facilitate delivery of a therapy delivery device into a pterygopalatine fossa (PPF) of a subject , said apparatus comprising:a curvilinear body having a distal end portion, a proximal end portion, and an intermediate portion extending between said distal and proximal end portions, said proximal end portion being defined by oppositely disposed first and second surfaces, said proximal end portion and said intermediate portion defining a longitudinal plane that extends between said proximal and distal end portions;said distal end portion having an arcuate configuration relative to said longitudinal plane and being defined by oppositely disposed third and fourth surfaces.2. The surgical guide of claim 1 , wherein said third surface has a flattened cross-sectional shape and said fourth surface has an elliptical cross-sectional shape.3. A surgical guide to facilitate delivery of a therapy delivery device into the PPF of a subject claim 1 , said apparatus comprising:a curvilinear body having a distal end portion, a proximal end portion, and an intermediate portion extending between said distal and proximal end portions, said proximal end portion being defined by oppositely disposed first and second surfaces, said proximal end portion and said intermediate portion defining a longitudinal plane that extends ...

SURGICAL TOOLS TO FACILITATE DELIVERY OF A NEUROSTIMULATOR INTO THE PTERYGOPALATINE FOSSA

A surgical tool configured to facilitate delivery of a neurostimulator to a craniofacial region of a subject includes a handle portion, an elongate shaft having a contoured distal portion, and an insertion groove on the elongate shaft. The elongate shaft is configured to be advanced under a zygomatic bone along a maxillary tuberosity towards a pterygopalatine fossa. The distal portion includes a distal dissecting tip. The insertion groove is configured to receive, support, and guide a medical device or instrument. 1. A surgical tool configured to provide surgical access to a craniofacial region of a subject , said surgical tool comprising:a handle portion;an elongate shaft comprising a contoured distal portion, said distal portion shaped and configured to maintain contact with a posterior maxilla and elevate a periosteum off of the posterior maxilla to avoid soft tissue dissection, said distal portion including a distal dissecting tip; andan insertion groove on said elongate shaft configured to receive, support, and guide a tunneling member.2. The surgical tool of claim 1 , wherein said distal dissecting tip has a flared configuration.3. The surgical tool of claim 1 , wherein said handle portion further comprises a proximal portion and an intermediate portion that extends between said proximal and distal portions claim 1 , said proximal and intermediate portions defining a longitudinal plane that extends therebetween claim 1 , said distal portion having an arcuate configuration relative to said longitudinal plane.4. The surgical tool of claim 3 , wherein said insertion groove is recessed into said elongate shaft.5. The surgical tool of claim 1 , wherein said insertion groove tapers from a distal end of said insertion groove to a proximal end of said insertion groove claim 1 , said insertion groove having a first depth at said proximal end that is greater than a second depth at said distal end.6. The surgical tool of claim 4 , wherein said insertion groove is located ...

SYSTEM AND METHOD FOR OPERATIONAL AND BEHAVIORAL BUSINESS INTELLIGENCE

A non-transitory computer readable medium can be programmed to provide an operational-behavioral business intelligence system that includes an idea manager programmed to manage ideas submitted by a user. Each idea can be stored in a knowledgebase and be capable of validation and conversion into an experiment. An experiment manager can be programmed to manage each experiment, including design, execution and analysis thereof. Each experiment can employ a performance indicator to provide a measure of performance based on behavior probe data captured via a behavior probe, the measure of performance being stored as experiment data for each respective experiment. A continuous positive reinforcement (CPR) engine can generate CPR data to provide substantially continuous reinforcement to users based on the data stored in the knowledgebase to drive business processes innovation. 1. A non-transitory computer readable medium programmed to provide an operational-behavioral business intelligence system , comprising:an idea manager programmed to manage ideas submitted by a user, each idea being stored in a knowledgebase and being capable of validation and conversion into an experiment;an experiment manager programmed to manage each experiment, including design, execution and analysis thereof, each experiment employing a performance indicator to provide a measure of performance based on behavior probe data captured via a behavior probe, the measure of performance being stored as experiment data for each respective experiment; anda continuous positive reinforcement (CPR) engine to generate CPR data to provide substantially continuous reinforcement to users based on the data stored in the knowledgebase to drive business processes innovation.2. The computer readable medium of claim 1 , further comprising:a probe device configured to monitor a predetermined behavior of a user and to communicate a behavior signal indicative of the behavior of the user; anda data capture module ...

SYSTEM AND METHOD FOR WOUND HEALING

A system is provided for healing a wound. The system includes a flexible body, a therapeutic agent delivery mechanism, a suction mechanism, and a power source. The flexible body includes a cover film having oppositely disposed first and second surfaces that define a compartment. The compartment includes a first porous material, a second porous material, and at least one electrode disposed therein. The second porous material is disposed between the first porous material and the at least one electrode. The therapeutic agent delivery mechanism and the suction mechanism are fluidly connected to the compartment. The power source is in electrical communication with the at least one electrode. 1. A system for healing a wound of a subject , said system comprising:a flexible body including a cover film having oppositely disposed first and second surfaces that define a compartment, said compartment including a first porous material, a second porous material, and at least one electrode disposed therein, said second porous material being disposed between said first porous material and said at least one electrode;a therapeutic agent delivery mechanism in fluid communication with said compartment;a suction mechanism in fluid communication with said compartment; anda power source in electrical communication with said at least one electrode.2. The system of claim 1 , wherein a wound-contacting portion of said compartment is porous and includes a series of output ports and uptake ports that extend through said wound-contacting portion.3. The system of claim 1 , wherein a sheet member is disposed between said first and second porous materials.4. The system of claim 1 , wherein said sheet member prevents the movement of fluid between said first and second porous materials.5. The system of claim 1 , wherein said at least one electrode is lasso-shaped.6. The system of claim 1 , wherein said at least one electrode is an interdigitated electrode.7. The system of claim 1 , wherein said ...

APPARATUS AND METHOD FOR TREATING A NEUROMUSCULAR DEFECT

One aspect of the present disclosure relates to a treatment probe comprising an elongated body member and a needle portion. The elongated body member can have a proximal end portion and a distal end portion. The needle portion can be connected to the distal end portion. The needle portion can include at least one electrode and at least one fluid port. The at least one electrode and the at least one fluid port can be configured to deliver electrical energy and a tumescent fluid, respectively, so that superficial tissue planes overlying a target nerve are protected from inadvertent heat damage as a result of application of electrical energy to a target nerve. 1. A treatment probe comprising:an elongated body member having a proximal end portion and a distal end portion; anda needle portion connected to said distal end portion, said needle portion including at least one electrode and at least one fluid port, said at least one electrode and said at least one fluid port being configured to deliver electrical energy and a tumescent fluid, respectively, so that superficial tissue planes overlying a target nerve are protected from inadvertent heat damage as a result of application of electrical energy to a target nerve.2. The treatment probe of claim 1 , wherein said at least one electrode and said at least one fluid port are oppositely disposed from one another.3. The treatment probe of claim 1 , wherein said at least one electrode and said at least one fluid port are radially offset from one another.4. The treatment probe of claim 1 , wherein said at least one electrode and said at least one fluid port are radially aligned with one another.5. The treatment probe of claim 1 , wherein said at least one electrode and said at least one fluid port are axially offset from one another.6. The treatment probe of claim 1 , wherein said needle portion further includes at least one sensing electrode that is axially spaced apart from said at least one electrode.7. The treatment probe ...

APPARATUS AND METHOD FOR TREATING A NEUROMUSCULAR DEFECT

A method is provided for treating a neuromuscular defect in a subject. One step of the method includes locating a target nerve. After locating the target nerve, a treatment probe is provided. The treatment probe includes an elongated body member having a proximal end portion and a distal end portion. The distal end portion includes an energy delivery mechanism for stimulating or ablating the target nerve, a monitoring mechanism, and a fluid aspiration/delivery mechanism. Next, the target nerve is verified as an appropriate target for ablation by stimulating and then monitoring the target nerve via the energy delivery mechanism and the monitoring mechanism, respectively. After verifying the target nerve, a tumescent fluid is injected into the tissue surrounding the target nerve. An electric current is then delivered to the energy delivery mechanism to substantially ablate the target nerve. 1. A method for treating a neuromuscular defect in a subject , said method comprising the steps of:locating a target nerve;providing a treatment probe, the treatment probe comprising an elongated body member having a proximal end portion and a distal end portion, the distal end portion including an energy delivery mechanism for stimulating or ablating the target nerve, a monitoring mechanism, and a fluid aspiration and delivery mechanism;verifying that the target nerve is an appropriate target for ablation by stimulating and then monitoring the target nerve via the energy delivery mechanism and the monitoring mechanism, respectively;injecting a tumescent fluid into the tissue surrounding the target nerve; anddelivering an electric current to the energy delivery mechanism to substantially ablate the target nerve;wherein the neuromuscular defect is selected from the group consisting of cosmetic defects, neuromuscular pain and headaches.2. (canceled)3. The method of claim 1 , wherein the cosmetic defect is selected from the group consisting of skin furrows claim 1 , frowning wrinkles ...

SYSTEM AND METHOD FOR TREATING OBSTRUCTIVE SLEEP APNEA

One aspect of the present disclosure relates to a system for treating obstructive sleep apnea in a subject. The system can include a power source and a neuromuscular stimulator in electrical communications with the power source. The neuromuscular stimulator can include a controller and at least one electrode. The controller can be configured to receive certain power and stimulation parameters associated with a therapy signal from the power source. The at least one electrode can be configured to deliver the therapy signal to a target tissue associated with control of a posterior base of the tongue of the subject. 1. A method for treating disordered breathing that occurs during sleep in a subject comprising:obtaining a neurostimulator comprising a lead having an electrode located thereon;positioning the neurostimulator so that the electrode and an electromyogram (EMG) sensor are in electrical communication with a muscle or nerve that controls an upper airway of the subject;monitoring the subject for an EMG signal indicative of a certain period of a respiratory cycle of the subject and by sensing EMG activity of the muscle;activating the neurostimulator to provide an electrical signal to the muscle or nerve in response to the EMG signal to decrease the subject's airway resistance and treat the sleep disordered breathing.2. The method of claim 1 , wherein the EMG sensor is located on the lead.3. The method of claim 1 , wherein the certain period of the subject's respiratory cycle is an onset of an inspiration phase and the electrical stimulation is provided at this time.4. The method of claim 3 , wherein the electrical stimulation ends at an onset of an exhalation phase of the respiratory cycle.5. The method of claim 1 , wherein the certain period of the subject's respiratory cycle is prior to an onset of an inspiration phase but after an expiration phase and the electrical stimulation of the upper airway is provided at this time.6. The method of claim 1 , wherein the ...

SYSTEM AND METHOD FOR WOUND HEALING

A system is provided for healing a wound. The system includes a flexible body, a therapeutic agent delivery mechanism, a suction mechanism, and a power source. The flexible body includes a cover film having oppositely disposed first and second surfaces that define a compartment. The compartment includes a first porous material, a second porous material, and at least one electrode disposed therein. The second porous material is disposed between the first porous material and the at least one electrode. The therapeutic agent delivery mechanism and the suction mechanism are fluidly connected to the compartment. The power source is in electrical communication with the at least one electrode. 114-. (canceled)15: A method for healing a wound , said method comprising the steps of:(a) providing a system comprising a flexible body, a therapeutic agent delivery mechanism, a suction mechanism and a power source, the flexible body including a cover film having oppositely disposed first and second surfaces that define a compartment, the compartment including a first porous material, a second porous material, and at least one electrode disposed therein, the second porous material being disposed between the first porous material and the at least one electrode, the therapeutic agent delivery mechanism and the suction mechanism being in fluid communication with the compartment, the power source being in electrical communication with the at least one electrode;(b) placing a wound-contacting portion of the compartment into contact with the wound;(c) delivering at least one therapeutic agent to the wound; and(d) activating the suction mechanism to remove at least one of fluid or debris from the wound;(e) optionally repeating steps (c)-(d) until the wound is sufficiently healed.16: The method of claim 15 , wherein said step of delivering the at least one therapeutic agent to the wound further comprises the steps of:causing the at least one therapeutic agent and oxygen to flow through the ...

Apparatus and method for treating a neuromuscular defect

One aspect of the present disclosure relates to a treatment probe comprising an elongated body member and a needle portion. The elongated body member can have a proximal end portion and a distal end portion. The needle portion can be connected to the distal end portion. The needle portion can include at least one electrode and at least one fluid port. The at least one electrode and the at least one fluid port can be configured to deliver electrical energy and a tumescent fluid, respectively, so that superficial tissue planes overlying a target nerve are protected from inadvertent heat damage as a result of application of electrical energy to a target nerve.

ENDOSCOPE FOR TISSUE DISSECTION AND VISUALIZATION

One aspect of the present disclosure relates to an endoscope for facilitating a medical procedure by creating an anatomic space in or adjacent a target bodily tissue to be imaged. The endoscope can comprise a flexible, elongate tubular member defining a central lumen and an expandable dissecting member coupled to a distal end of the tubular member. The tubular member can further include at least one imaging channel extending longitudinally therethrough. The at least one imaging channel can include a visualization system for conveying an image from the distal end of the tubular member to a user. The expandable dissecting member can define a channel in fluid communication with the central lumen of the tubular member. The expandable dissecting member can extend beyond the distal end of the tubular member. 1. An endoscope for facilitating a medical procedure by creating an anatomic space in or adjacent a target bodily tissue to be imaged , the endoscope comprising:a flexible, elongate tubular member having a distal end and defining a central lumen, the tubular member further including at least one imaging channel extending longitudinally therethrough, the at least one imaging channel including a visualization system for conveying an image from the distal end of the tubular member to a user; andan expandable dissecting member coupled to the distal end of the tubular member, the expandable dissecting member defining a channel in fluid communication with the central lumen of the tubular member, the expandable dissecting member extending beyond the distal end of the tubular member.2. The endoscope of claim 1 , wherein the expandable dissecting member is permanently affixed to the distal end of the tubular member.3. The endoscope of claim 1 , wherein the expandable dissecting member is a compliant balloon.4. The endoscope of claim 1 , wherein the visualization system further comprises:an imaging element disposed within a first imaging channel; anda lighting element disposed ...

SYSTEMS AND METHODS THAT USE MULTI-MODAL IMAGING FOR ENHANCED RESOLUTION IMAGES

One aspect of the present disclosure relates to a system that can employ multi-modal imaging to provide an image with an enhanced resolution. In some instances, the multi-modal imaging can allow an operator to determine and control a tissue margin without the need for intra-operative tissue pathology. The system can include an imaging system that includes a gamma camera to detect a gamma image and an optical imaging modality to detect an optical image. The system can also include a display device to display an enhanced gamma image created based on a function of the optical image. The enhanced gamma image illustrates a characteristic of a disease in the field of view (e.g., a lymphatic pathway, a sentinel lymph node target, or a satellite disease state). 1. (canceled)2. (canceled)3. (canceled)4. (canceled)5. (canceled)6. (canceled)7. (canceled)8. (canceled)9. (canceled)10. (canceled)11. (canceled)12. (canceled)13. (canceled)14. (canceled)15. (canceled)16. (canceled)17. (canceled)18. (canceled)19. The method of claim 18 , wherein the resolution of the gamma image is increased based on a difference between the collimator-based optical image and the lens-based optical image.20. (canceled)21. A system comprising:a non-transitory memory storing instructions; and receive a collimator-based optical image of a field of view related to a patient, a lens-based optical image of the field of view, and a gamma image of the field of view;', 'determine a resolution corruption function for optical imaging based on the collimator-based optical image of the field of view and the lens-based optical image of the field of view;', 'approximate a resolution corruption function for gamma imaging based on the resolution corruption function for optical imaging; and', 'enhance a resolution of the gamma image of the field of view based on the resolution corruption function for gamma imaging., 'a processor to access he memory and execute the instructions to22. The system of claim 21 , wherein ...

SURGICAL TOOLS TO FACILITATE DELIVERY OF A NEUROSTIMULATOR INTO THE PTERYGOPALATINE FOSSA

A surgical tool configured to facilitate delivery of a neurostimulator to a craniofacial region of a subject includes a handle portion, an elongate shaft having a contoured distal portion, and an insertion groove on the elongate shaft. The elongate shaft is configured to be advanced under a zygomatic bone along a maxillary tuberosity towards a pterygopalatine fossa. The distal portion includes a distal dissecting tip. The insertion groove is configured to receive, support, and guide a medical device or instrument. 121-. (canceled)22. A method for delivering a neurostimulator to within close proximity of a sphenopalatine ganglion (SPG) , said method comprising the steps of:making an incision at a gingival-buccal insertion site;inserting a first surgical tool into the incision;advancing the first surgical tool under a zygomatic bone along a maxillary tuberosity towards a PPF to form a first surgical access cavity;forming a second surgical access cavity at an end of the first surgical access cavity that is in close proximity to the SPG; anddelivering the neurostimulator in close proximity to the SPG via the first and second surgical access cavities.23. The method of claim 22 , wherein said advancing step further comprises the steps of:advancing the first surgical tool until a distal dissecting tip of the first surgical tool engages a junction formed by a posterior maxillary buttress and a pterygoid plate; androtating the first surgical tool in a superior direction until the distal dissecting tip is positioned about the PPF.24. The method of claim 22 , wherein said step of forming a second surgical access cavity further comprises the steps of:advancing a tunneling member into contact with an insertion groove of the first surgical tool;urging the tunneling member along the insertion groove into contact with an end of the first surgical access cavity; andadvancing the tunneling member through the end of the first surgical access cavity to form the second surgical access ...

PROSTHETIC IMPLANTS

A prosthetic implant includes an anterior surface, configured for at least partial contact with an underside of a patient's facial soft tissue. A posterior surface is oppositely placed to the anterior surface. The posterior surface is configured for at least partial contact with a patient's facial bony tissue when the anterior surface is in at least partial contact with the patient's facial soft tissue. An implant body is defined by the anterior and posterior surfaces and extends transversely therebetween. A selected portion of the posterior surface has a texture that mechanically differs from a texture of a majority of the anterior surface. 1. A prosthetic implant , comprising:an anterior surface, configured for at least partial contact with an underside of a patient's facial soft tissue;a posterior surface, oppositely placed to the anterior surface, the posterior surface being configured for at least partial contact with a patient's facial bony tissue when the anterior surface is in at least partial contact with the patient's facial soft tissue; andan implant body defined by the anterior and posterior surfaces and extending transversely therebetween; andwherein a selected portion of the posterior surface has a texture that mechanically differs from a texture of a majority of the anterior surface.2. The prosthetic implant of claim 1 , being a prosthetic chin implant.3. The prosthetic implant of claim 1 , being a prosthetic malar implant.4. The prosthetic implant of claim 1 , being a prosthetic orbital implant.5. The prosthetic implant of claim 1 , being a prosthetic nasal implant.6. The prosthetic implant of claim 1 , wherein both the posterior and anterior surfaces are made entirely of porous silicone.7. The prosthetic implant of claim 1 , wherein both the posterior and anterior surfaces are made entirely of solid silicone.8. The prosthetic implant of claim 1 , wherein a selected one of the posterior and anterior surfaces is made entirely of porous silicone and ...

SURGICAL GUIDE AND METHOD FOR GUIDING A THERAPY DELIVERY DEVICE INTO THE PTERYGOPALATINE FOSSA

A surgical guide to facilitate delivery of a therapy delivery device into the pterygopalatine fossa of a subject includes a curvilinear body having a distal end portion, a proximal end portion, and an intermediate portion extending between the distal and proximal end portions. The proximal end portion is defined by oppositely disposed first and second surfaces. The proximal end portion and the intermediate portion define a longitudinal plane that extends between the proximal and distal end portions. The distal end portion has an arcuate configuration relative to the longitudinal plane and is defined by oppositely disposed third and fourth surfaces. 119-. (canceled)20. A method of delivering a neurostimulator to within close proximity of a sphenopalatine ganglion (SPG) , comprising:making an incision over a skull;inserting a surgical guide into the incision;advancing the surgical guide under a zygomatic bone along a maxillary tuberosity towards a PPF; anddelivering the neurostimulator in close proximity to the SPG.21. The method of claim 20 , wherein said advancing step further comprises advancing the surgical guide until a distal tip of the surgical guide engages a junction formed by a posterior maxillary buttress and a pterygoid plate.22. The method of further comprising rotating the surgical guide in a superior direction until the distal tip is within the PPF.23. The method of claim 20 , wherein the incision is made at a gingival-buccal insertion site.24. The method of claim 20 , wherein the neurostimulator is delivered in close proximity to the SPG from the surgical guide.2527-. (canceled)28. A method of treating a neurological disorder claim 20 , comprising:making an incision over a skull;inserting a surgical guide into the incision;advancing the surgical guide under a zygomatic bone along a maxillary tuberosity towards a pterygopalatine fossa (PPF);delivering a neurostimulator in close proximity to the sphenopalatine ganglion (SPG); andapplying an electrical ...

System and method for treating obstructive sleep apnea

One aspect of the present disclosure relates to a system for treating obstructive sleep apnea in a subject. The system can include a power source and a neuromuscular stimulator in electrical communications with the power source. The neuromuscular stimulator can include a controller and at least one electrode. The controller can be configured to receive certain power and stimulation parameters associated with a therapy signal from the power source. The at least one electrode can be configured to deliver the therapy signal to a target tissue associated with control of a posterior base of the tongue of the subject.

APPARATUS AND METHOD FOR TREATING A NEUROMUSCULAR DEFECT

A method is provided for treating a neuromuscular defect in a subject. One step of the method includes locating a target nerve. After locating the target nerve, a treatment probe is provided. The treatment probe includes an elongated body member having a proximal end portion and a distal end portion. The distal end portion includes an energy delivery mechanism for stimulating or ablating the target nerve, a monitoring mechanism, and a fluid aspiration/delivery mechanism. Next, the target nerve is verified as an appropriate target for ablation by stimulating and then monitoring the target nerve via the energy delivery mechanism and the monitoring mechanism, respectively. After verifying the target nerve, a tumescent fluid is injected into the tissue surrounding the target nerve. An electric current is then delivered to the energy delivery mechanism to substantially ablate the target nerve. 1. A method for treating a neuromuscular defect in a subject , said method comprising the steps of:locating a target nerve;providing a treatment probe, the treatment probe comprising an elongated body member having a proximal end portion and a distal end portion, the distal end portion including an energy delivery mechanism for stimulating or ablating the target nerve, a monitoring mechanism, and a fluid aspiration and delivery mechanism;verifying that the target nerve is an appropriate target for ablation by stimulating and then monitoring the target nerve via the energy delivery mechanism and the monitoring mechanism, respectively;injecting a tumescent fluid into the tissue surrounding the target nerve; anddelivering an electric current to the energy delivery mechanism to substantially ablate the target nerve.2. The method of claim 1 , wherein the providing step further comprises providing a treatment probe including a hollow post member that is integrally formed with the distal end portion of the elongated body claim 1 , the hollow post member including an electrode and a sensor ...

Surgical guide and method for guiding a therapy delivery device into the pterygopalatine fossa

A surgical guide to facilitate delivery of a therapy delivery device into the pterygopalatine fossa of a subject includes a curvilinear body having a distal end portion, a proximal end portion, and an intermediate portion extending between the distal and proximal end portions. The proximal end portion is defined by oppositely disposed first and second surfaces. The proximal end portion and the intermediate portion define a longitudinal plane that extends between the proximal and distal end portions. The distal end portion has an arcuate configuration relative to the longitudinal plane and is defined by oppositely disposed third and fourth surfaces.

SYSTEM AND METHOD FOR TREATING OBSTRUCTIVE SLEEP APNEA

One aspect of the present disclosure relates to a system for treating obstructive sleep apnea in a subject. The system can include a power source and a neuromuscular stimulator in electrical communications with the power source. The neuromuscular stimulator can include a controller and at least one electrode. The controller can be configured to receive certain power and stimulation parameters associated with a therapy signal from the power source. The at least one electrode can be configured to deliver the therapy signal to a target tissue associated with control of a posterior base of the tongue of the subject. 1. A system for treating obstructive sleep apnea (OSA) in a subject , the system comprising:a power source; anda neuromuscular stimulator in electrical communication with the power source, the neuromuscular stimulator including a controller and at least one electrode, the controller being configured to receive certain power and stimulation parameters associated with a therapy signal from the power source, the at least one electrode being configured to deliver the therapy signal to a target tissue associated with control of a posterior base of the tongue of the subject.2. The system of claim 1 , wherein the communicating power source is located external to the subject.3. The system of claim 2 , wherein the power and stimulation parameters are delivered to the controller via inductive coupling.4. The system of claim 1 , wherein the neuromuscular stimulator is configured for implantation on or in a mandible of the subject.5. The system of claim 1 , wherein the target tissue is one or more muscles of the anterior lingual musculature.6. The system of claim 5 , wherein the target tissue is one of a genioglossus muscle claim 5 , an anterior belly digastric muscle claim 5 , a hyoglossus muscle claim 5 , and a mylohyoid muscle.7. The system of claim 1 , further including a sensing component configured to detect at least one physiological parameter claim 1 , or a ...

INTRA-ORAL APPLIANCES AND SYSTEMS

An intra-oral appliance to power and/or communicate with a neurostimulator is provided. The intra-oral appliance can include a teeth covering configured to fit over mandibular incisor, canine and/or premolar teeth of a human being and a remote controller in the form of a housing extending posteriorly from and operably connected to the teeth covering. The housing can include a power source, a coupling coil configured to transmit power to the neurostimulator and configured to receive power from an external charger, and electrical circuitry operably connected to the coupling coil and the power source. 1. An intra-oral appliance to treat sleep disordered breathing in a patient comprising:a teeth covering configured to fit over mandibular incisor, canine and/or premolar teeth of a human being;a remote controller comprising a housing extending posteriorly from and operably connected to the teeth covering, the remote controller sized and dimensioned to be positioned, in its entirety, in the intra-oral cavity and configured to be positioned underneath the ventral surface of the tongue in an operable configuration, the housing comprising:a power source; aa coupling coil configured to transmit power to a neurostimulator and configured to receive power from an external charger; anda control circuit operably connected to the coupling coil and the power source.2. The intra-oral appliance of claim 1 , wherein the coupling coil is configured to receive power from an external charger.3. The intra-oral appliance of claim 1 , wherein the coupling coil is an induction coil.4. A neurostimulator system comprising the intra-oral appliance of and further comprising:a neurostimulator comprising a stimulating electrode and an antenna or coil configured to receiving power and/or stimulation parameters from the remote controller.5. The neurostimulation system of claim 4 , wherein the neurostimulator comprises an injectable implant comprising:a cylindrical, hermetically-sealed body having a ...

SPRING BASED ELECTRICAL POWER GENERATOR

The present invention discloses a spring based generator for conversion of the vibrational energy into significantly storable electrical energy. The present invention's generator is portable and does not need any fluid like petrol, diesel, water etc. for its starting or running. The manufacturing and maintenance cost of the generator is highly less due to least complex assembly. The present invention creates minimum noise and provides continuous power generation. 1. A spring based generator for conversion of a vibrational energy into an electrical energy , the generator comprises:a self-starter;a flywheel, wherein the flywheel is connected to the self-starter through an electromechanical means;an alternator, wherein the alternator is connected to the flywheel through an electromagnetic coupling;an electrical motor, wherein the electrical motor is connected to the flywheel through a feedback medium, wherein the feedback medium is electrically coupled to the electrical motor;a spring assembly, wherein the plurality of spring assembly comprises multiple stages of spring energy generation units known as spring drum assembly, wherein the first stage of the spring assembly is connected to electrical motor;an oil mechanism, wherein the oil mechanism is provided at the bottom of the spring assembly;a primary transmission gear, wherein the primary transmission gear provides interstage connections for power transmission in the spring assembly;a secondary transmission gear, wherein the secondary transmission gear connects the spring assembly to a bearing, wherein the bearing is further connected to the alternator;a power supply, wherein the power supply acts as the feedback to the electric motor;a control panel, wherein the control panel manages the speed and power flow for the generator;a base frame, wherein the base frame houses the generator.2. The generator according to in claim 1 , wherein the output power taken from the alternator is in the range of 90-95%.3. The ...

APPARATUS AND METHOD FOR TREATING A NEUROMUSCULAR DEFECT

A method is provided for treating a neuromuscular defect in a subject. One step of the method includes locating a target nerve. After locating the target nerve, a treatment probe is provided. The treatment probe includes an elongated body member having a proximal end portion and a distal end portion. The distal end portion includes an energy delivery mechanism for stimulating or ablating the target nerve, a monitoring mechanism, and a fluid aspiration/delivery mechanism. Next, the target nerve is verified as an appropriate target for ablation by stimulating and then monitoring the target nerve via the energy delivery mechanism and the monitoring mechanism, respectively. After verifying the target nerve, a tumescent fluid is injected into the tissue surrounding the target nerve. An electric current is then delivered to the energy delivery mechanism to substantially ablate the target nerve. 1: A method for treating a neuromuscular defect in a subject , said method comprising the steps of:locating a target nerve;providing a treatment probe, the treatment probe comprising an elongated body member having a proximal end portion and a distal end portion, the distal end portion including an energy delivery mechanism for stimulating or ablating the target nerve, and a monitoring mechanism;injecting a tumescent fluid into the tissue surrounding the target nerve; anddelivering an electric current to the target nerve via the energy delivery mechanism.2: The method of claim 1 , wherein the neuromuscular defect is selected from the group consisting of cosmetic defects claim 1 , neurological movement disorders claim 1 , neuromuscular pain claim 1 , and headaches.3: The method of claim 2 , wherein the cosmetic defect is selected from the group consisting of skin furrows claim 2 , frowning wrinkles claim 2 , contractions claim 2 , spasms claim 2 , and neck bands.4: The method of claim 2 , wherein the neurological movement disorder is selected from the group consisting of torticollis ...

METHODS OF USING NERVE EVOKED POTENTIALS TO MONITOR A SURGICAL PROCEDURE

Methods for intra-operatively monitoring nerve evoked potentials such as somatosensory nerve evoked potentials during a surgical procedure. The methods include orthrodromic and antidromic monitoring of nerve evoked potentials. Monitoring includes navigating the surgical pathway to avoid insult to anatomical tissue, minimizing activation of sensory nerves that result in undesirable side effects in a patient, and determining the suitable location for placement of an implantable medical device. 1. A method of intra-operatively monitoring a surgical procedure performed on a patient comprising:stimulating a stimulation site of the patient's body;recording electrical activity from a recording site of the patient's body;determining if the stimulation elicits a somatosensory nerve evoked potential in a nerve comprising sensory fibers that propagates in an antidromic direction and innerves the recording site; andmonitoring the surgical procedure based on the determination.2. The method of claim 1 , wherein stimulating a stimulation site of the patient's body comprises stimulating a stimulation site of the patient's autonomic nervous system.3. The method of claim 2 , wherein the stimulation site is a sphenopalatine ganglion (SPG).4. The method of claim 1 , wherein the surgical procedure is implanting a neurostimulator in a patient's body at a suitable implantation site.5. The method of claim 4 , wherein monitoring the surgical procedure based on the determination comprises identifying the suitable implantation site for the neurostimulator.6. The method of claim 5 , wherein the suitable implantation site is within a PPF.7. The method of claim 4 , wherein monitoring the surgical procedure based on the determination comprises navigating a surgical pathway to the suitable implantation site.8. The method of claim 1 , wherein the nerve is selected from the group consisting of a superior labial nerve claim 1 , a greater palatine nerve claim 1 , a lesser palatine nerve claim 1 , a ...

SYSTEM AND METHOD FOR TREATING OBSTRUCTIVE SLEEP APNEA

One aspect of the present disclosure relates to a system for treating obstructive sleep apnea in a subject. The system can include a power source and a neuromuscular stimulator in electrical communications with the power source. The neuromuscular stimulator can include a controller and at least one electrode. The controller can be configured to receive certain power and stimulation parameters associated with a therapy signal from the power source. The at least one electrode can be configured to deliver the therapy signal to a target tissue associated with control of a posterior base of the tongue of the subject. 121-. (canceled)22. A system for improving disordered breathing that occurs during sleep in a subject , the system comprising:a stimulator comprising an array of electrodes configured to stimulate distal arborizing branches of a hypoglossal nerve of the subject;a power source external to the stimulator; anda controller programmed to deliver a therapy signal to the array to stimulate the distal arborizing branches of the hypoglossal nerve to improve the subject's disordered breathing that occurs during sleep.23. The system of claim 22 , wherein the controller is configured to store one or more stimulation programs.24. The system of claim 22 , wherein the controller is programmed with a predetermined program.25. The system of claim 22 , wherein the controller is programmed with an adaptive program.26. The system of claim 22 , wherein the controller is programmed with a predetermined program and an adaptive program.27. The system of claim 22 , further comprising:an electromyogram (EMG) electrode configured to detect muscle activity of a muscle that controls tongue movement.28. The system of claim 27 , wherein the stimulator comprises a lead and the array of electrodes and the EMG electrode are disposed on the lead.29. The system of claim 22 , wherein the stimulator further includes:a housing within which the controller is contained; andan electrical lead ...

SYSTEM AND METHOD FOR WOUND HEALING

A system is provided for healing a wound. The system includes a flexible body, a therapeutic agent delivery mechanism, a suction mechanism, and a power source. The flexible body includes a cover film having oppositely disposed first and second surfaces that define a compartment. The compartment includes a first porous material, a second porous material, and at least one electrode disposed therein. The second porous material is disposed between the first porous material and the at least one electrode. The therapeutic agent delivery mechanism and the suction mechanism are fluidly connected to the compartment. The power source is in electrical communication with the at least one electrode. 121-. (canceled)22. A system for healing a wound of a subject , said system comprising:a flexible body including a cover film having oppositely disposed first and second surfaces that define a compartment, said compartment including a first porous material, a second porous material, and at least one electrode disposed therein, said second porous material being disposed between said first porous material and said at least one electrode;a therapeutic agent delivery mechanism in fluid communication with said compartment;a suction mechanism in fluid communication with said compartment; anda power source in electrical communication with said at least one electrode.23. The system of claim 22 , wherein a wound-contacting portion of said compartment is porous and includes a series of output ports and uptake ports that extend through said wound-contacting portion.24. The system of claim 22 , wherein said at least one electrode is lasso-shaped.25. The system of claim 22 , wherein said at least one electrode is an interdigitated electrode.26. The system of claim 22 , wherein said therapeutic agent delivery mechanism further comprises: a valve; a therapeutic agent source in fluid communication with said valve; and an oxygen source in fluid communication with said valve.27. The system of claim 26 ...

SYSTEM AND METHOD FOR TREATING OBSTRUCTIVE SLEEP APNEA

One aspect of the present disclosure relates to a system for treating obstructive sleep apnea in a subject. The system can include a power source and a neuromuscular stimulator in electrical communications with the power source. The neuromuscular stimulator can include a controller and at least one electrode. The controller can be configured to receive certain power and stimulation parameters associated with a therapy signal from the power source. The at least one electrode can be configured to deliver the therapy signal to a target tissue associated with control of a posterior base of the tongue of the subject. 121-. (canceled)22. A method for treating disordered breathing that occurs during sleep in a subject , the method comprising:obtaining a neurostimulator comprising an electrode;placing at least a portion of the neurostimulator on or in the subject's mandible;positioning the electrode in electrical communication with an anterior lingual muscle or a nerve that innervates an anterior lingual muscle; andactivating the neurostimulator to deliver an electrical signal to the muscle or the nerve to open an oropharyngeal airway.23. The method of claim 22 , wherein the anterior lingual muscle is a genioglossus muscle claim 22 , an anterior belly digastric muscle claim 22 , a hyoglossus muscle claim 22 , a mylohyoid muscle claim 22 , or a combination thereof.24. The method of claim 22 , wherein the nerve is a hypoglossal nerve claim 22 , a distal arborizing branch of a hypoglossal nerve at or near its neuromuscular junction claim 22 , or a combination thereof.25. The method of claim 22 , wherein the neurostimulator includes a first and a second electrical lead claim 22 , each of which includes an electrode connected thereto.26. The method of claim 25 , further comprising:forming a first hole through the mandible on a first side of a midline of the subject;forming a second hole through the mandible on a second opposing side of the midline of the subject;inserting the ...

SYSTEMS AND METHODS THAT USE MULTI-MODAL IMAGING FOR ENHANCED RESOLUTION IMAGES

One aspect of the present disclosure relates to a system that can employ multi-modal imaging to provide an image with an enhanced resolution. In some instances, the multi-modal imaging can allow an operator to determine and control a tissue margin without the need for intra-operative tissue pathology. The system can include an imaging system that includes a gamma camera to detect a gamma image and an optical imaging modality to detect an optical image. The system can also include a display device to display an enhanced gamma image created based on a function of the optical image. The enhanced gamma image illustrates a characteristic of a disease in the field of view (e.g., a lymphatic pathway, a sentinel lymph node target, or a satellite disease state). 1. A system comprising: ["a gamma camera that emits gamma rays to record a gamma image of a field of view including a portion of a patient's body, wherein the gamma camera comprises a collimator;", "an optical imaging modality that emits optical rays to record an optical image of the field of view including the portion of the patient's body; and"], 'an imaging system comprisinga display device to display the an enhanced gamma image of the field of view that illustrates a characteristic of a disease in the field of view,wherein the enhanced gamma image is created based on a function of the optical image.2. The system of claim 1 , wherein the imaging system further comprises a beam splitter to allow a portion of the optical rays to pass through the collimator and another portion of the optical rays to be recorded without passing through the collimator.3. The system of claim 2 , wherein the function of the optical image comprises a resolution corruption function determined based on the collimator-based optical image and the non-collimated optical image.4. The system of claim 3 , wherein the resolution corruption function is determined based on a difference between the collimator-based optical image and the non- ...

INTRA-ORAL APPLIANCES AND SYSTEMS

An intra-oral appliance to power and/or communicate with a neurostimulator is provided. The intra-oral appliance can include a teeth covering configured to fit over mandibular incisor, canine and/or premolar teeth of a human being and a remote controller in the form of a housing extending posteriorly from and operably connected to the teeth covering. The housing can include a power source, a coupling coil configured to transmit power to the neurostimulator and configured to receive power from an external charger, and electrical circuitry operably connected to the coupling coil and the power source. 1. An intra-oral appliance to treat sleep disordered breathing in a patient comprising:a teeth covering configured to fit over mandibular incisor, canine and/or premolar teeth of a human being;a remote controller comprising a housing extending posteriorly from and operably connected to the teeth covering, the remote controller sized and dimensioned to be positioned, in its entirety, in the intra-oral cavity and configured to be positioned underneath the ventral surface of the tongue in an operable configuration, the housing comprising:a power source; aa coupling coil configured to transmit power to a neurostimulator and configured to receive power from an external charger; anda control circuit operably connected to the coupling coil and the power source.2. The intra-oral appliance of claim 1 , wherein the coupling coil is configured to receive power from an external charger.3. The intra-oral appliance of claim 1 , wherein the coupling coil is an induction coil.4. A neurostimulator system comprising the intra-oral appliance of and further comprising:a neurostimulator comprising a stimulating electrode and an antenna or coil configured to receiving power and/or stimulation parameters from the remote controller.5. The neurostimulation system of claim 4 , wherein the neurostimulator comprises an injectable implant comprising:a cylindrical, hermetically-sealed body having a ...

ENDOSCOPE FOR TISSUE DISSECTION AND VISUALIZATION

One aspect of the present disclosure relates to an endoscope for facilitating a medical procedure by creating an anatomic space in or adjacent a target bodily tissue to be imaged. The endoscope can comprise a flexible, elongate tubular member defining a central lumen and an expandable dissecting member coupled to a distal end of the tubular member. The tubular member can further include at least one imaging channel extending longitudinally therethrough. The at least one imaging channel can include a visualization system for conveying an image from the distal end of the tubular member to a user. The expandable dissecting member can define a channel in fluid communication with the central lumen of the tubular member. The expandable dissecting member can extend beyond the distal end of the tubular member. 1. An endoscope for facilitating a medical procedure by creating an anatomic space in or adjacent a target bodily tissue to be imaged , the endoscope comprising:a flexible, elongate tubular member having a distal end and defining a central lumen, the tubular member further including at least one imaging channel extending longitudinally therethrough, the at least one imaging channel including a visualization system for conveying an image from the distal end of the tubular member to a user; andan expandable dissecting member coupled to the distal end of the tubular member, the expandable dissecting member defining a channel in fluid communication with the central lumen of the tubular member, the expandable dissecting member extending beyond the distal end of the tubular member.2. The endoscope of claim 1 , wherein the expandable dissecting member is permanently affixed to the distal end of the tubular member.3. The endoscope of claim 1 , wherein the expandable dissecting member is a compliant balloon.4. The endoscope of claim 1 , wherein the visualization system further comprises:an imaging element disposed within a first imaging channel; anda lighting element disposed ...

Compounded latex saturants for porous backings

Abstract The present invention is directed to a novel latex saturant for porous backings and porous sheets, especially for paper backings used in pressure sensitive adhesive tapes. The saturant includes a latex an elastomer base compounded with both tackifying resin and filler. The elastomer base may be either an acrylate or a rubber, such as carboxylated styrene-butadiene rubber. Paper incorporating the saturant of the invention provides a backing that retains flexibility, tensile and elongation, and gives an improved drape or hand. Pressure sensitive adhesive tapes which employ the compounded saturated backing show good adhesion with aging.

Apparatus and Method for Dermatological Wound Healing

A method is provided for treating a dermatological wound. A first step of the method includes providing an iontophoretic apparatus. The iontophoretic apparatus includes at least one surface for contacting a surface of the dermatological wound, a current source electrically coupled to the apparatus, a suction mechanism operably coupled to the apparatus, and a source of therapeutic molecules. A second step of the method includes placing the at least one surface of the iontophoretic apparatus into contact with at least a portion of the dermatological wound surface. A third step of the method includes activating the current source so that a plurality of therapeutic molecules is delivered to the dermatological wound. A fourth step of the method includes activating the suction mechanism to remove fluid and/or debris from the dermatological wound. The second, third, and fourth steps of the method are repeated until the dermatological wound is sufficiently healed.

System and method for wound healing

A system is provided for healing a wound. The system includes a flexible body, a therapeutic agent delivery mechanism, a suction mechanism, and a power source. The flexible body includes a cover film having oppositely disposed first and second surfaces that define a compartment. The compartment includes a first porous material, a second porous material, and at least one electrode disposed therein. The second porous material is disposed between, the first porous material and the at least one electrode. The therapeutic agent delivery mechanism and the suction mechanism are fluidly connected to the compartment. The power source is in electrical communication with the at least one electrode.

Apparatus for phacoemulsifying cataractous-lens tissue within a protected environment

An instrument for ophthalmic surgery to remove cataractous-lens tissue has an elongate stem which enables external manipulation at its proximal end and which at its distal end presents a cutter adjacent a transiently open cavity into which cut or chopped tissue can be manipulated. The instrument provides for selectively operated closure of the thus-loaded cavity, an event which must occur before laser radiation can issue within the cavity, in fragmenting or emulsifying reduction of cut or chopped tissue within the cavity. Thus, reduced, the fragmented material is extracted by an aspirating flow of liquid. This process is repeated until the capsulary bag has been cleared of cataractous material, be it nuclear or cortical.

Method and apparatus for attaching a wing to a body

A method and apparatus for assembling an aircraft. A wing spar fitting is connected to a spar in a wing for the aircraft. A body frame fitting is connected to a frame in a body for the aircraft. The locations and orientations of the body frame fitting and the wing spar fitting allow for the body frame fitting to be attached to the wing spar fitting when the wing is positioned for attachment to the body of the aircraft. The wing is positioned with respect to the body of the aircraft for attachment to the body. The body frame fitting and the wing spar fitting are attached to each other with a set of fasteners after the body frame fitting is aligned to the wing spar fitting without penetrating any sealed areas in the wing, wherein the wing is attached to the body by a mechanical joint that is formed by the body frame fitting and the wing spar fitting.

Depth-based image blurring

An image such as a light-field image may be processed to provide depth-based blurring. The image may be received in a data store. At an input device, first and second user input may be received to designate a first focus depth and a second focus depth different from the first focus depth, respectively. A processor may identify one or more foreground portions of the image that have one or more foreground portion depths, each of which is less than the first focus depth. The processor may also identify one or more background portions of the image that have one or more background portion depths, each of which is greater than the second focus depth. The processor may also apply blurring to the one or more foreground portions and the one or more background portions to generate a processed image, which may be displayed on a display device.

Rolled liquid filter using fluted media

A filter apparatus includes a fluted filter element in a filter housing having a first open end and a second closed end. The filter element includes fluted filter media coiled into a cylindrical shape and may include an end cap for support and fluid control. Fluid flows into the open end and either around the filter to the closed and back through the filter element or through the filter element to the closed end and then back through a central opening in the filter element.

Filtering device with corrugated and rolled filter media

A filter apparatus includes a fluted filter element in a filter housing having a first open end and a second closed end. The filter element includes fluted filter media coiled into a cylindrical shape and may include an end cap for support and fluid control. Fluid flows into the open end and either around the filter to the closed and back through the filter element or through the filter element to the closed end and then back through a central opening in the filter element.

Eye surgical instrument

Method and apparatus are disclosed for surgically removing surface portions of an eye such as cataract tissue. The eye surface portions to be removed are vaporized by a carbon dioxide laser beam. Smoke and vaporized portions are withdrawn by a vacuum pump.

Impact wrench

Board road bundle cradle

The present disclosure of a board bundle cradle is for use with the free end of a dip stick having a pivoted work carrier at its free end having a hook which has a horizontally rotatable work carrier movable through an arc of the order of 106° horizontally relative to the pivot. The board road board bundle cradle has a pair of spaced apart end frames each of which has a base member adapted to receive and support a bundle of boards to be laid into a board road. A major and a minor board bundle containment member upstands from each end of each base member and extends from the upper portion of each major support member. Spacer means between the spaced apart end frames rigidly secures the frames together. The portion lying between the upwardly forwardly inclined member and the upper free end of the minor board bundle containment member defines the loading mouth of the cradle through which a bundle of boards to be laid are introduced to the base members of each end frame. The cradle is carried by the hook on the horizontally rotatable work carrier and is engagable with the spacer at the upwardly forwardly inclined member of each end frame to rotate the cradle containing a board bundle alternately ninety degrees for presenting the boards for laying both longitudinally and transversely of the direction of the board road to be laid.

Pleated filter and a method for making the same

The present invention relates to a filter including a filter element having a succession of inner connected pleats. The pleats have successive pleat tips which define an outer boundary of the filter element. Covering the entire outer boundary of the filter element is a permeable generally inelastic sheet which extends across successive pleat tips. The sheet is adhesively affixed to the pleat tips for maintaining spacing of the pleats. The sheet comprises a plurality of randomly arranged plastic filaments which are bonded to each other junction between the filaments and define a plurality of randomly spaced and shaped openings for allowing substantially unrestricted flow of a fluid through the sheet.

Filter with a filter screen

Apparatus for treating a neuromuscular defect

One aspect of the present disclosure relates to a treatment probe comprising an elongated body member and a needle portion. The elongated body member can have a proximal end portion and a distal end portion. The needle portion can be connected to the distal end portion. The needle portion can include at least one electrode and at least one fluid port. The at least one electrode and the at least one fluid port can be configured to deliver electrical energy and a tumescent fluid, respectively, so that superficial tissue planes overlying a target nerve are protected from inadvertent heat damage as a result of application of electrical energy to a target nerve.

Track wrench

Cross-reactive influenza A immunization

This disclosure relates to methods and compositions for stimulating in an individual an influenza A virus protective response which is subtype cross-protective. Influenza A virus NS1 protein, or a T cell epitope thereof, is administered to the individual in an amount sufficient to stimulate the virus protective response.

Electrical connector for overlapped conductors

PATENT ABSTRACT OF THE DISCLOSURE: An electrical connector for connecting overlapped conductors is disclosed. The connector is similar to connectors of the clam shell type having a pair of compressibly-movable hingedly-connected ends which accommodate the conductors therebetween. The ends of the connectors are positioned in spaced mutually parallel relationship. The conductors are supported therebetween. A hinge connecting the two ends is collapsibly-deformable to maintain the relative parallel positions of the ends throughout compression of the connector.

Radiation-hardenable diluents

Radiation curable compositions containing outstanding reactive diluents have been developed. The diluents are lower alkyl ether acrylates and methacrylates of particular alkoxylated and non-alkoxylated polyols. Examples are mono-methoxy trimethylolpropane diacrylate, mono-methoxy neopentyl glycol monoacrylate and mono-methoxy, ethoxylated neopentyl glycol monoacrylate having an average of about two moles of ethylene oxide.

Implantable micro-system for treatment of hydrocephalus

An implantable system for the treatment of hydrocephalus includes a plurality of microneedles in a fixed array relative to each other adapted to extend from the subarachnoid space containing CSF surrounding the brain, through dura mater forming the wall of the sinus. A microvalve is associated with a proximal end of each of the microneedles and is adapted to permit the flow of cerebrospinal fluid (CSF) from the subarachnoid space through the wall of the superior sagittal sinus and deposited in the venous return of the brain. The method of treating hydrocephalus with the system of this invention also constitutes a part of the invention.

System for wound healing

A system is provided for healing a wound. The system includes a flexible body, a therapeutic agent delivery mechanism, a suction mechanism, and a power source. The flexible body includes a cover film having oppositely disposed first and second surfaces that define a compartment. The compartment includes a first porous material, a second porous material, and at least one electrode disposed therein. The second porous material is disposed between, the first porous material and the at least one electrode. The therapeutic agent delivery mechanism and the suction mechanism are fluidly connected to the compartment. The power source is in electrical communication with the at least one electrode.

Radiation-hardenable diluents

IMPROVED RADIATION-HARDENABLE DILUENTS ABSTRACT OF THE DISCLOSURE Radiation curable compositions containing outstanding reactive diluents have been developed. The diluents are lower alkyl ether acrylates and methacrylates of particular alkoxylated and non-alkoxylated polyols, Examples are mono-methoxy trimethylolpropane diacrylate, mono-methoxy neopentyl glycol monoacrylate and mono-methoxy, ethoxylated neopentyl glycol monoacrylate having an average of about two moles of ethylene oxide.

H-tap compression connector

An improved H-tap compression connector is crimp-connected to a pair of electrical conductors by dies of a crimping tool. The connector includes a connector body having a generalry H-shaped configuration defining a pair of conductor nests opening in 'opposite directions from a transverse axis. The connector includes first and second pairs of spaced-apart crimpable sidewalls extending in opposite directions from the transverse axis. Each pair of sidewalls includes a first sidewall having an inwardly curved distal extent defining a die engagement location and a second sidewall having a die engagement location at the end thereof. The die engagement locations of each of the sidewalls of each pair are located substantially equidistant from the transverse axis. The die engagement location of the curved distal extent of the one sidewall is constructed to have a radius of curvature which is substantially identical to the radius of curvature of the die to prevent rotation of the connector within the dies during crimping.

Method and apparatus for remote release of hammer and follow block chain connection

The present disclosure is directed to a hammer and follow block chain remote release device and method to eliminate the need of a human having to ride the pile driving leads until the follow block is separated from the hammer. This is attained by passing a chain through the follow block and over horns on the hammer. A remote release device is connected to one end of the chain and an elongated link secured to the other end of the chain is engaged with the release device and a remotely actuated coupling member is pulled to release the connection between the chain and release device to permit separation of the follow block from the hammer by passage of the chain through the follow block and over the horns on the hammer.

Prosthetic implants

A prosthetic implant (100) includes an anterior surface (102), configured for at least partial contact with an underside of a patient's facial soft tissue. A posterior surface (204) is oppositely placed to the anterior surface. The posterior surface is configured for at least partial contact with a patient's facial bony tissue when the anterior surface is in at least partial contact with the patient's facial soft tissue. An implant body is defined by the anterior and posterior surfaces and extends transversely there between. A selected portion of the posterior surface has a texture that mechanically differs from a texture of a majority of the anterior surface.

Method and device for corneal shaping and refractive correction

A method and device for benign, non-surgical external shaping of corneal tissue to compensate, by refractive correction, for deviations from normal focussing. Corneal tissue is externally gently removed by erosion to a maximum 30 % depth, within several seconds, by an imperceptibly felt, highly controlled and limited area, isotonic water jet, exerting a total force of at most several ounces. The jet is directed to erode corneal tissue to provide an increase in curvature to correct for far-sightedness i.e., to refocus a perceived image from beyond retina onto the surface of the retina. To correct for near-sightedness and to refocus a perceived image from in front of the retina onto the surface of the retina, the jet is directed to flatten out by eroding, a central portion of corneal tissue, to decrease curvature. The jet is either applied by a nozzle or array of nozzles. The jet is applied and directed, in a computer controlled, raster or similar type movement, until the desired diopter change is effected. Since there is no heating of the cornea, with concomitant wound healing induced deviations, correction can be effected within a deviation range from normal of 0.25 diopters, comparable to that of corrective lenses and contact lenses.

Implantable device for treatment of hydrocephalus

An implantable device for the treatment of hydrocephalus using a stent having a peripheral wall and an interior passageway and wherein a plurality of microneedles project outwardly from the peripheral and each needle includes a microneedle passageway from an aperture adjacent a distal end of the microneedle to a proximal end of the microneedle adjacent the peripheral wall. A corresponding plurality of one-way microvalves is positioned at the proximal ends of the microneedle and wherein the microneedle passageway is in fluid communication with the interior passageway whenever the one-way microvalve is open. When the stent is implanted in the superior sagittal sinus with the distal end of the plurality of microneedles positioned within the subarachnoid space and at least one of the plurality of microvalves is open, the stent permits cerebrospinal fluid to pass from the subarachnoid space to the superior sagittal sinus.

Method for the stimulation of cell growth and the inhibition of cell proliferation by the utilization of selenodithiols such as selenodiglutathione

This invention relates to the inhibition of cell proliferation in mammalian host organisms. More particularly the invention relates to the utilization of selenodithiol compositions, particularly selenodiglutathione (GSSeSG) within a narrow concentration range, in which it is both effective as an inhibitor of cancer tumor cell proliferation in mammals, particularly in the prevention of neoplastic cell division in humans, while substantially non toxic outside this narrow range to the treated host organism. The invention also relates to a method for stimulating cellular proliferation at lower concentration of selenodiglutathione.

System for treating obstructive sleep apnea using a neuromuscular stimulator

Retainer for percussive tools

System and method for treating obstructive sleep apnea

One aspect of the present disclosure relates to a system for treating obstructive sleep apnea in a subject. The system can include a power source and a neuromuscular stimulator in electrical communications with the power source. The neuromuscular stimulator can include a controller and at least one electrode. The controller can be configured to receive certain power and stimulation parameters associated with a therapy signal from the power source. The at least one electrode can be configured to deliver the therapy signal to a target tissue associated with control of a posterior base of the tongue of the subject.

H-tap compression connector

An improved H-tap compression connector is crimp-connected to a pair of electrical conductors by dies of a crimping tool. The connector includes a connector body having a generalry H-shaped configuration defining a pair of conductor nests opening in 'opposite directions from a transverse axis. The connector includes first and second pairs of spaced-apart crimpable sidewalls extending in opposite directions from the transverse axis. Each pair of sidewalls includes a first sidewall having an inwardly curved distal extent defining a die engagement location and a second sidewall having a die engagement location at the end thereof. The die engagement locations of each of the sidewalls of each pair are located substantially equidistant from the transverse axis. The die engagement location of the curved distal extent of the one sidewall is constructed to have a radius of curvature which is substantially identical to the radius of curvature of the die to prevent rotation of the connector within the dies during crimping.

Inner tube

Test apparatus for electronic equipment

Portable test apparatus for tracing faults in electronic equipment including or associated with a microprocessor comprises a control module connectible to a test configuring module. The control module comprises a microprocessor, a data storage memory programmed to contain operating software associated with the microprocessor, a keyboard and visual display screen for enabling intercommunication between a user of the apparatus and the microprocessor, and a data bus for data transfer between the control module and the test configuring module. The test configuring module comprises a data storage memory programmed to contain a range of diagnostic tests specific to a particular type of electronic equipment to be tested and accessible by the microprocessor, and a latched data bus for data transfer between the test configuring module and the unit to be tested. Faults can be traced to a general area (RAM, ROM, I/O, etc.) using pre-programmed diagnositic analysis, and down to component level using static stimulus tests.

DEVICE FOR OPHTHALMOLOGICAL SURGERY.

Multi-electrode cochlear implant

A multi-electrode cochlear implant (10) is taught in which approximately twenty or more insulated metal wires (14, 16) are wound aaround a flexible tube (12). These wires (14, 16) are held in place with a further layer of dielectric insulating material (18). The insulation is selectively removed with a laser beam to form electrodes (20). Two or more layers or valences of wires (54, 58, 62) can be used, with the inner layer of wires (62) terminating distal to the outer layers (54, 58) to provide a stepwise approximation of the tapering of the scala tympani. A core (68) of shape memory material may be introduced into the tube (12), so that the implant will retain an effective shape after implantation.

Cross-reactive influenza a immunization

This disclosure relates to methods and compositions for stimulating in an individual an influenza A virus protective response which is subtype cross-protective. Influenza A virus NS1 protein, or a T cell epitope thereof, is administered to the individual in an amount sufficient to stimulate the virus protective response.

Can holder

Bit-chuck retainer

Biasing mechanism for impact wrenches

Zig-zagged swept wing kite

Mechanism for opening collapsed tubular cartons

System and method for wound healing

A system is provided for healing a wound. The system includes a flexible body, a therapeutic agent delivery mechanism, a suction mechanism, and a power source. The flexible body includes a cover film having oppositely disposed first and second surfaces that define a compartment. The compartment includes a first porous material, a second porous material, and at least one electrode disposed therein. The second porous material is disposed between, the first porous material and the at least one electrode. The therapeutic agent delivery mechanism and the suction mechanism are fluidly connected to the compartment. The power source is in electrical communication with the at least one electrode.

Safety device

Impact tool

Cross-reactive influenza a immunization

This disclosure relates to methods and compositions for stimulating in an individual an influenza A virus protective re-sponse which is subtype cross-protective. Influenza A virus NS1 protein, or a T cell epitope thereof, is administered to the indi-vidual in an amount sufficient to stimulate the virus protective response.

Furnace.

Adjustable sutures and methods of making and using the same

A surgical suture is made from materials which, upon the application of at least one source of non-frictional energy, such as may be imparted by using a laser, alter dimension. In essence, these sutures can be made to contract and/or expand after implantation in tissues and/or prosthetic materials. The absorbtion of energy may be enhanced by the addition to the suture material of an energy absorbing substance, and especially a substance that is selected to absorb radiation at the wavelength of a laser used to effect the dimensional change. Preferred sutures are comprised of cross-linked polyolefins. These fibers may also be formed into composite structures, such as a braided structure, to provide a composite suture having selectively alterable component suture elements.

Method of making an electrical terminal

A method of forming an electrical terminal is disclosed. A longitudinal extent of stock tubular material is provided. An end portion thereof is divided into two leg extents each having an unsupported extent extending from the tubular material. The legs are the formed into electrical terminal portions which accommodate thereinbetween a terminal post.

Dental casting-machine.

Thermodynamically defined gene specific primers

A method is described for designing an optimized nucleic acid primer for reverse transcription of an RNA target of interest, comprising selecting a region of the RNA target for designing a target-specific primer, and optimizing the kinetics of hybridization of candidate target-specific primers to the RNA, thereby designing an optimized target-specific RT primer. The RT primers can be about 7-9 nt in length and are useful, for example, for formalin fixed paraffin embedded tissue samples or for other compromised samples. Primers designed by the method, RT-PCR methods using such primers, and kits containing the primers are presented.

Sectional column for architectural purposes.

Fireproof stariway

Portable pneumatic nail driving apparatus

My invention is directed to portable pneumatic nail driving devices for working with large nails ranging in size from 30 to 90 penny which are fed from a primary chute through a transfer chute to a nail driving barrel carried by a base frame. Upstanding from the base are guides over which slides a cradle to which a pneumatic gun having a chisel is carried to that the chisel enters the barrel after a nail has been introduced to drive the nail. Such apparatus is used in the construction of board roads in swamps incident to oil field work.

Spring handle for percussive tools

Rail car panel

Radiation-hardenable diluents

Radiation curable compositions containing outstanding reactive diluents have been developed. The diluents are lower alkyl ether acrylates and methacrylates of particular alkoxylated and non-alkoxylated polyols. Examples are mono-methoxy trimethylolpropane diacrylate, mono-methoxy neopentyl glycol monoacrylate and mono-methoxy, ethoxylated neopentyl glycol monoacrylate having an average of about two moles of ethylene oxide.

Valve lever and latch construction for glassware forming machines

DEVICE FOR OPHTHALMOLOGICAL SURGERY.

Fluid filter cartridge with replaceable filter element

A spin-on fluid filter cartridge with a replaceable filter element is provided, comprising a housing, an internally threaded annular collar, a replaceable filter element, and an externally threaded mounting head assembly. The annular collar is secured inside the housing at its open upper end. A sealing ring in an annular channel adjacent the external threads of the mounting head seals the cartridge when the mounting head assembly is threaded into the annular collar.

Bottle packaging machine

High contact density planar array

A laminated multi-electrode biocompatible implant (8), comprising a first layer (30) of flexible, biocompatible dielectric material having a first, exposed surface. A second layer (20) of flexible biocompatible dielectric material, is adhered to the first layer. Further, a third layer (10) of flexible biocompatible dielectric material is adhered to the second layer (20). Additionally, a first conductive trace (18) is interposed between the first layer (30) and the second layer (20) and a second conductive trace (18) is interposed between said second layer (20) and said third layer (10). Finally, a first conductor, which breaches said first layer, conductively connects the first conductive trace to the exposed surface of the first layer, thereby forming a first electrode (44) and a second conductor (40), which breaches the first layer (30) and the second layer (20), conductively connects the second conductive trace (18) to the exposed surface of the first layer (30), thereby forming a second electrode (42).

Improvements in telephones

Sealing device

Machine for loading cans into cartons

Systems for improving sleep disordered breathing

A neuromodulation system is provided herein. The system can include a neuromodulation device, an electronics package, which can be part of the neuromodulation device; an external controller; a sensor; and a computing device. The neuromodulation device can include a neuromodulation lead having a lead body configured to be bent to a desired shape and to maintain that shape in order to position the electrodes relative to neural and/or muscular structures when fully deployed. The neuromodulation device can also include an antenna including an upper and a lower coil electrically connected to each other in parallel. The computing device can execute a closed-loop algorithm based on physiological sensed data relating to sleep.

System and methods for treating neuropathologies of a subject

A method of treating an animal subject includes applying a nerve interface to a muscle pedicle of the subject, the muscle pedicle having a peripheral nerve inserted therein, wherein the nerve interface is configured to provide electrical communication between the peripheral nerve and an electronic device.

Inner tube

Receptor de potencia de estimulación implantable y sistemas

Un estimulador neuromuscular implantable inalámbrico incluye una antena para producir una corriente inducida en respuesta a estar dispuesto en un campo electromagnético. La antena incluye un sustrato que tiene una superficie superior y una superficie inferior. Una bobina superior que incluye una pluralidad de espiras de bobina está dispuesta en la superficie superior del sustrato. Una bobina inferior que incluye una pluralidad de espiras de bobina está dispuesta en la superficie inferior del sustrato. Las bobinas superior e inferior están conectadas eléctricamente entre sí en paralelo. La conexión en paralelo puede facilitarse mediante una pluralidad de conectores que se extienden a través del sustrato y conectan eléctricamente la bobina superior con la bobina inferior. En una configuración de ejemplo, los conectores conectan cada vuelta de la bobina superior con una vuelta correspondiente de la bobina inferior. (Traducción automática con Google Translate, sin valor legal)

V-belt, belt sleeve and process

Abstract of the Disclosure A cured and inverted V-belt sleeve having several spaced circumferential V-grooves that bound oversized V-belt side portions of inverted V-belts is provided by fabricating a belt sleeve with tensile member interpositioned between inner and outer uncured elastomeric layers, skiving circumferential strips of elastomeric material from the outer layer, and molding and curing the skived belt sleeve. Portions of the molded V-sides are then removed by grinding to define raw V-sidewall portions having predetermined spacing. Individual coverless or "raw edge" V-belts or V-belts banded together at their top surfaces are provided with an optional molded circumferential depression that forms an arch in the belt bottom surfaces and juxtaposed embedded reinforcements. Individual belts are provided by severing circumferentially along the grooves. According to this process the amount of cured cord therefore unreprocessable elastomer which has to be removed is greatly reduced.

Last

Vorrichtung zum entfernen von linsentrübungsgewebe

Method of processing auditory data

A method for the real-time transformation of an electrical signal representative of a sound wave that includes the steps of providing an electrical signal representative of a sound wave, transforming that signal to an analytic representation, and passing said electrical signal, in parallel, through a number of bandpass filters (50) to create a set of time domain real and imaginary band limited signals. Next, a stream of instantaneous phase angle and magnitude vaulues for each of said set of time domain real and imaginary band limited signals is computed (52). Thirdly, a stream of electrical pulses or other digital representation of the phase, instantaneous frequency, and magnitude information (56) is computed for delivery to a cochlear implant or transmission for decoding and sythesis of the original sound.